Home

New Model

1. Fraa ugo basile ASE L Hi fh V A a 5 ps e eta E ess jpam NEW on the 2014 version The new launcher application makes it possible to manage other UB behavioral cages with the same Touch Screen Controller 40500 001 just purchase the hardware and the application software for the addi Remote Control feature will make remote service and software upgrades extremely simple 55 ACTIVE AVOIDANCE Set Up Instrument Description Different set ups depending on animal rat or mouse and number of cages can be obtained by combining the following elements Programming Recording Unit with Shocker Rat Cage up to 4 with one controller or Mouse Cage up to 4 with one controller Expansion Box for multiple cage set up Programming Recording Unit The 40500 001 Programming Recording Unit encom passing all controls incorporates a constant current high precision 8 pole shocker and manages data acqui sition data are stored inside the unit and can be down loaded via the USB key provided as standard for further processing via Excel Access etc r fi GENERAL SETUP i est RESULTS HELP H TIME UNE Step 1 Experiment Step 2 Conditioned Stimulus Step 3 Uncanditionss Stimulus Type of event o CONDITIONED Sound 5 63 7 45 25 2000Hr Intensity 20 amp Start 5 21 0 pepieren Frequency Hz 2000 Stop s 23 0 Ge ustnn
2. G www ugobasile com ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS what s new new DCA Software for PAM eVF GSM new conditioning cage system new software one touch screen unit to manage different tests e fear conditioning e active avoidance e passive avoidance exanmms soon touch screen e learned helplessness 9 een gee controller mouse multi maze system T Y and radial maze with a single equipment Jugo basile TRANSFORMING IDEAS INTO INSTRUMENTS your trusted partner roadmapping the future of behavioral research PAIN AND INFLAMMATION 37140 37215 35100 37370 37360 37300 37450 38500 38450 37450 275 31300 37100 ET S FOC CO seiatgrsiiirii risina arini an eet E ra NEEESE EEES EEE ERE Analgesy Meter ces iaeenacespcineeearereutetedic te acecien besrnte anes coktetnucieaslesdiecstnepiesuee stones avant Orie Hot Cold Plate iirvsexreczuacceausvsanies sve renvenuecaneataactedavennecseeinivdemcemietrtacutiarsnatieracucetesutenie Plantar Test Hargreaves s Apparatus oo cccccccccccccccccceecesseeecesevesesseeeveesesuneeesens IE IUPUI UNIE hspeseecte dessarodciecpsoeasiavane E EE E EEE EER TETEE etx aed I R Heat Flux Radiometer siacedencerse nea wenrseceucosheees usauieereacgereeceregunsbeieatenrsseninmmarenerantiens Dynamic Plantar Aesthesio Meter 0 00 0 0c ccc ccc ccc ecc cee cenceeeeceecesceceeeeeesuseeeecesensanes P A
3. A kit of Mouse adaptors for both thermal and mecha nical stimulation is available see ordering information The System and Method for Assessing Hypersensitivity to Orofacial Thermal and Mechanical Stimulation U S Provisio nal Patent Application 61 235 590 was invented by J Fehren bacher M Henry and K Hargreaves in the Laboratory of Dr Hargreaves at UT San Antonio and developed commercially by Ugo Basile R amp D Dr Fehrenbacher is now at IUPUI Indianapolis Ordering Information 31300 Complete system for one animal 31320 Complete system for two animals 31340 Complete system for four animals 31300 001 Electronic unit four channels 31300 002 Additional cage assembly includes thermal and mechanical stimulators and feeding detector 31300 003 Circulating water bath 31300 010 ORO Software for data acquisition and analysis from up to 16 cages 31300 323 Optional Kit of Mouse adaptors for thermal and mechanical stimulation for 1 cage Bibliography M Prochazkova et alia Activation of cyclin dependent kinase 5 mediates orofacial mechanical hyperalgesia Molecular Pain 9 66 1 12 2013 M Cha et alia Assessment of chronic trigeminal neuro pathic pain by the orofacial operant test in rats Behav Brain Research 234 82 90 2012 Fehrenbacher J C et al 2010 Characterization of a novel orofacial behavioral assay to assess hyperalgesia to thermal and mechanical stimulation submitt
4. BP RECORDER No 58500 Animal Restrainers A convenient animal restrainer is provided with the standard package Our models are particularly suitable being purpose fully designed for this task as they feature aconical muzzle to confine the animal head availability in 4 different diameters for rat and one for mouse to fit various animal sizes telescope adjustable length a quick fit release back lid with an ample U shaped tail slot convenient ventilation slots and selection of heat conduc tive materials to guarantee body heat dissipation Optional Rat Heater Scanner The 58000 845 Heating Box for Rats is a compact temperatu re controlled cupboard inside dimension 57 w x47 d x20 h cm to lodge and prewarm 5 rats each in its individual holder 58000 840 designed for mice has the same dimensions but it accommodates 6 mouse holders The 58000 850 Rat Scanner is also available combining the pre warming features with an electrical pneumatical switch which enables connection of up to 5 rodents tail cuff and pul se pick up positioned on their tail to scan their blood pressure in sequence Both Rat Scanner and Heating Boxes come complete with hol ders of selectable diameter Ordering Information 58500 BP RECORDER with accessories for RAT 8mm pulse pick up 13mm cuff 50mm holder 58600 BP RECORDER with accessories for MOUSE 3mm pulse pick up 6mm cuff 30mm holder 58550 BP RE
5. Ugo Basile more than 10 000 citations LESION MAKING DEVICE Controls The instrument controls are all placed on the top panel the parameter are set by two thumb wheel switches Current output adjustment in the range 10UA to 99mMA Pulse duration from 0 1 to 99 seconds The mode of operation can be selected via a 3 position switch Continuous the current flows through the prepa ration in a continuous mode Stand By the instrument is ready to operate but the output stage is not energized Pre set Duration the current flow is timed accor ding to the setting Three binding posts are located at the upper right of the Lesion Maker either the red and the black can be connected to the lesion making electrode The other binding post is usually connected to a pad electrode with electrolyte on the preparation Either red or black may be grounded via the green binding post Led Indicators Three LED indicators are embodied on the top panel POWER green which lights when the unit is ON MONIT red which monitors the presence of lesion current VIOL yellow which indicates when the cur rent does not correspond to the setting Electrodes Usual needle electrodes prepared by the researcher ac cording to his her experimental needs can be used in conjunction with the 53500 Lesion Making Device We have the capability and will to manufacture elec trodes based on the
6. mum frequency in this case becomes 100 Hz ECT Monitor 57800 015 When connection to an oscil loscope or data acquisition system this useful accessory is required to guarantee a simple and safe way to monitor the ECT output The risk of damage to the ECT Unit due to accidental wrong connections is avoided when using the ECT Monitor Ordering Information 57800 ECT Unit standard package including 57800 001 Pulse Generator 57800 002 Set of Auricular Electrodes 57800 302 Instruction Manual on CD E WP 008 Mains Cord Accessories and Spares 57800 003 Set of Corneal Electrodes 57800 320 Set of 4 Felt Pads for Auricular Electrodes 57800 010 Bipolar Inverter 57800 015 ECT Monitor Physical Instrument Size 27 W x37 D x13 H cm Weight 3 4Kg Packing 45x34x26cm Shipping Weight 5Kg Bibliography K M Ryan et alia Electroconvulsive Stimulation Alters Levels of BDNF asociated microRNAs Neuroscience Letters avaiable May 2013 N K Thomas et alia Triheptanoin in Acute Mouse Sei zure Models Epilepsy Research 99 3 312 317 2012 S A Epps et alia Seizure Susceptibility and Epilep togenesis in a Rat Model of Epilepsy and Depression Co Morbidity Neuropsychopharmacol 37 2756 2763 2012 M Gasior et alia Anticonvulsant and Proconvulsant Actions of 2 deoxy D glucose Epilepsia 1 10 2010 A L Hartman et alia Efficacy of the Ketogenic Diet in the 6 Hz Seizure Test Epi
7. A Coluccia et alia Late Embryonic Exposure to All Trans Retinoic Acid Induces a Pattern of Motor NeuroToxicolo gy 30 1120 1126 2009 Rat UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 26 10 2014 ile AITO f Multiple Activity Cage General An animal level of general activity or locomotion is an indicator of drug action toxic substances neurological damage or daily rhythms in activity Activity data may be automatically and unobtru sively collected by many methods The Ugo Basile Activity Cage has proved to be of great value to record spontaneous co ordinate activity in rats and mice individual or groups and variation of this activity in time As the animal moves about a clear acrylic cage it interrupts one or more infrared beams The be ams are arranged in an array of emitters on one side of the cage detectors on another The lower IR array monitors horizontal movement while the upper IR array monitors vertical or rea ring activity The number of beam breaks is correlated with the amount of movement about the cage MAIN FEATURES MOTORY COORDINATION GRIP STRENGTH ACTIVITY With dedicated STAND ALONE CON software included TROLLER WITH EMBED DED PRINTER FOR GLP AND DATA SAFETY Measures horizontal and vertical activity in rats and mice useful in the following types of investigation General Toxicology ascertaining the action o
8. EThe effects of thiol modulators on nitrergic nerve and S nitrosothiols induced relaxa tion in duodenum J of Basic and Clinical Physiol amp Pharmacol 0 0 1 8 2013 M Bucci et alia Cross talk between toll like receptor 4 TLR4 and proteinase activated receptor 2 PAR2 is involved in vascular function Br J Pharmacol 168 2 411 420 2013 C Jelen et alia Bone scaffolds with homogeneous and discrete gradient mechanical properties Materials Science amp Engineering C 33 1 28 36 2013 M Volta et alia Pharmacological profile and antipar kinsonian properties of the novel nociceptin orphanin FQ receptor antagonist 1 1 cyclooctylmethyl 5 1 hydroxy 1 methyl ethyl 1 2 3 6 tetrahydropyridin 4 yl 3 ethyl 1 3 dihydro benzoimidazol 2 one GF 4 Peptides 31 1194 1204 2010 P U Ertug Protective effect of quercetin a polyphe nolic compound on mouse corpus cavernosum Fun damental amp Clinical Pharmacology 24 223 232 2010 O Desire et alia Antispasmodic and antioxidant acti vities of fractions and bioactive constituent davidige nin isolated from Mascarenhasia arborescens J Eth nopharmacology J Pharmacol Accepted May 2010 2004 D Currd et alia EVoltage gated calcium channels in volved in the inhibitory motor responses and asoac tive intestinal polypeptide release in the rat gastric fundus Eur J Pharmacol 628 207 213 2010 C Bel
9. The force is applied to the animal s paw which is placed on a small plinth under a cone shaped pu sher with a rounded tip The 37215 features a low voltage synchronous mo tor and conforms the CE rules The operator depresses a pedal switch to start the mechanism which exerts the force When the rat struggles the operator releases the pedal and reads off the scale the force at which the animal felt pain The standard 37215 can be convently used with mice However a dedicated model is also availa ble when lower pressure 50 is desirable model 37216 which includes a special chisel shaped pu sher Main Features e Randall Selitto Paw Pressure Test Same instrument three force ranges from 0 to 250 500 750 g Simple and reliable no calibration needed Classic method since the 1960s hundreds of papers published e Rapid Precise Screening of Analgesic Drugs Analgesy Meter No 37215 Principle of Operation The force applied to the paw by the plinth increases at a constant rate thus enabling perfect reproducible me asurements to be made The motor stops immediately the pedal is released After each test the slide should be returned to its star ting point by lifting it and pushing it to the left The force is measured on the scale calibrated in 10 gram steps by a pointer riveted to the slide The scale can be multiplied by 2 or 3 by placing on the slide one or two discs provide
10. ALLU aR ALLL Main Features 20 Filament Kit Graded Series of Nylon Monofilament color coded Rotating sleeve protects precision filament while in closed position 19 Von Frey Filaments have a long history of effective use in clinical settings and can be used to diagnose patho logies of hyper or hypo aesthesia The operating principle remains the same when the tip of a fiber of given length and diameter is pressed against the skin at right angles the force of application increases as long as the researcher continues to ad vance the probe until the fiber bends After the fiber bends continued advance creates more bend but not more force of application This principle makes it possible for the researcher using a hand held probe to apply a reproducible force within a wide tolerance to the skin surface Rodents exhibit a paw withdrawal reflex when the paw is unexpectedly touched The Touch Test Sensory Eva luator can be used on the Plantar surfaces of the foot of a rat or mouse and the animal will indicate sensation by pulling back its paw Replacement filaments available Subsets within the set of 20 probes distinguish pathologies on different parts of the body foot hand lip cheek etc Rotating sleeve protects precision filament while in closed po sition Grip sleeve and rotate handle Pivot filament head to begin testing Accessories For easy and quick stimulation of the plantar s
11. If the customer wishes to make use of other recording ap paratus the transducers can be supplied with appropriate Input Resistance connector on request we will be glad to provide transdu Input 7000hm cers with different connectors if available or to provide witing information and instruction Electrical Excitation max 15V DC or AC Output Resistance Output 10000hm Domes Non Linearity amp y The 17844 is provided Hysteresis max 0 5 FS l l with a dome provided Zero Balance max 30mm Hg with with stop cock Thermal Sensitivity Shift 0 15 C The dome has wings l for easy fitting on the Thermal Zero Shift max 0 25mm Hg C transducer A Temperature CT The dome should be fil JS an led bubbleless at max Storage Semperature l pressure of 5 0mmHg Range 20 70 C Insulation Resistance min 103MOhm 3 Leakage Current max 1 5pA at 250V 50Hz Ordering Information High Voltage Resistance 10KV between Dome and 3 17844 Pressure Transducer Sensonor type SP Transducer 844 complete with one dome 17844 001 lodged in its plastic case Length of Adapter Cable ca 30cm Length of Monitor cable ca 250cm Accessories ae 17844 001 Clear Polycarbonate Dome with Luer Lock Connector see compatibility Fitting complete with 3 way stopcock 17844 002 Set of 10 Clear Polycarbonate Dome with Luer Lock Fitting complete with 3 way stopcock Physical Weight 0 024Kg without cable 0 2Kg with
12. Instrument Descriptions The M thode de la Planche a Trous devised by Bois sier amp Simon see bibliography can be performed un der optimum conditions the recording of the head plunging or nose poking stereotype takes place automatically via miniature I R emitters receivers em bodied in the holes The instrument consists of a Board and a Control Unit Control Unit 6651 The control unit is lodged into a resilient cabinet whose front panel features the ACTIVITY display the RESET and TEST keys the LED visual indicators At every head plunging the ACT activity LED blinks and the read out increases by one digit A time constant has been provided to inhibit the circuit to record a rapid up amp down nose poking as it were a multiple event The figure remains frozen until the operator depresses the reset key again when placing a fresh mouse on the board Board 6652 The 40x40 cm board 2 2 cm thick is made of grey Per spex The matt finishing avoids reflections which may alter the behavior of the animal The board embodies 16 head plunging detectors each comprising an I R emitter and a diametrically op posed receiver flush mounted 1 cm below the upper panel The dimensioning of the board and holes has been op timized for mice in the 15 30 g range to provide negli gible false recordings Data Acquisition The 6650 Hole Board is provided with a connector for branchi
13. Up to 4 cages can be connected to the same Controller If more than one cage is connected an expansion box 40500 005 is required for each additional cage Passive Avoidance Cage step through Two types of cages are available 40552 designed for Rats dimensioned 57x27x30 h cm D 48x20x22 h cm 40553 designed for Mice dimensioned 47x18x25 h cm 1 D 38x9x17 h cm The cage is divided into two sections the START and ESCAPE compartments The start compartment is whi te and illuminated by a light fixture 3LED white light the escape compartment is dark and its grid floor is connected to the shocker The two compartments are divided by a partition which embodies an automatically operated sliding door at flo or level The door delay and the shock parameters can be preset on the touch screen of the controller accor ding to experience or data suggested by the literature No 40552 Rats 40553 Mice With the rodent in the START compartment the START button activates the timer providing the opening of the door after the preset delay The opening of the door enables the latency timer which stops at the animal crossing latency time is di splayed in 0 1s steps The door shuts one second after the crossing to prevent the the animal being upset or hurt by a too close door operation Ordering Information 40500 001 Programming Recording Unit amp Shocker 40550 010 P A Software and activation 40552 Rat Cage comp
14. sales ugobasile com TEL 39 0332744574 02 2013 48 GAS ANESTHESIA SYSTEM Ordering Information ANESTHESIA SYSTEMS 21050 Basic Single Output Anesthesia System including Digital Flowmeter for O or Me dical Air and TEC 3 vaporizer for Isoflurane 21100 Single Output Anesthesia System inclu ding 21050 2 passive scavengers evacuation tubing 21200 Double Output Anesthesia System Inclu ding 21050 4 passive scavengers evac tubing amp dual diverter manifold with humidifier 21400 Multiple Animal Anesthesia System in cluding 21050 8 passive scavengers evac tubing and Multiple Delivery Sy stem for 4 animals 21600 Multiple Animal Anesthesia System in cluding 21050 12 scavengers evac tubing and Multiple Delivery System for 6 animals ACCESSORIES Delivery Systems Masks amp Induction Boxes PS 0525 A Nose Cone Mask Circuit for Small Mice PS 0305 A Nose Cone Mask for Large Mice 3cm2 PS 0306 A Nose Cone Mask for Small Rats 4 5cma PS 0307 A Nose Cone Mask Medium Rats 5cm PS 0308 A Nose Cone Mask for Large Rats 5 5cm All masks are complete with diaphragm and inlet connector 7900 Induction Box for small rodents rats and mice dimensioned 25x13x13 h cm 7910 Large Induction Box 40x22x21 h cm 21100 790 Induction Box for small rodents airtight model with latch 25x13x13 h cm Special Systems with N20 22100 O2 N20 Anesthesia System
15. siology 112 1452 63 2010 A Rizzo et alia Effects of rosiglitazone a PPAR c ago nist on the contractility of bovine uterus in vitro J vet Pharmacol Therap 32 548 551 2009 L Natale et alia Interleukins 1 Beta and 6 Induce Fun ctional Alteration of Rat Colonic Motility An In Vitro Study Eur J Clin Investigation 33 8 704 712 2003 D Mitolo Chieppa et alia Involvement of K Opioid Receptors in Peripheral Response to Nerve Stimula tion in K Opioid Receptor Knockout Mice Autonomic amp Autacoid Pharmacology 22 4 233 239 2002 MAR Accomazzo et alia Leukotriene D4 Induced Acti vation of Smooth Muscle Cells From Human Bronchi Is Partly Ca2 Independent Am J Respir Crit Care Med 163 1 266 272 2001 M Shalev et alia Stimulation of P2y Purinoceptos Induces Via Nitric Oxide Production endothelium Dependent Relaxation of Human isolated Corpus Ca vernosum J Urol 161 955 959 1999 M C Breschi et alia Effects of Noise Stress on EFS Me diated Cholinergic and Inhibitory NANC Responses in Tracheae from Normal and Sensitized Guinea Pigs J Autonomic Pharmacol 17 6 353 363 1997 MK Sim et alia Presence of an Endothelial Esterase in the Rat Aorta Effects on the Actions of Ester and Non Ester Muscarinic Antagonists Endothelium 1 109 114 1993 High Sensitivity Transducer 7010 LW Tait et alia Hagfish natriuretic peptide changes urine
16. Capurro et alia Pharmacological Characterization of Memoquin a Multi Target Compound for the Treatment of Alzheimer s Disease PLoS ONE 8 2 e56870 2013 J Michaud et alia Hematopoietic MyD88 adaptor Pro tein Acts as a Natural Defense Mechanism for Cognitive Deficits in Alzheimer s Disease Stem Cell Reviews and Reports 8 3 898 904 2012 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 OPAC is 58 j ugo basile BEHAVIOUR CONDITIONING REWARD IDEAS INTO INST S PD TRANSFORMING www ugobasile com Passive Avoidance Step Down New Model Cat No 40570 General The Passive Avoidance step down cage for mice or immature rats is based on the step down scheme in which the animal is dropped on an elevated platform which becomes un comfortable because of vibrations The instrument basically consists of an arena shaped as a cage Cat No 47573 and a con trol unit with touch screen The method is based on the mouse tendency to step down a small platform uncomforta ble because of vibrations onto the floor of the testing apparatus which is electrified The animal inhibs its behaviour in order to avoid shock this is measured by longer laten cy or refusal to step down Latency is used to Measures the gt assess memory Step Down Cage ncrease dechan i Increase or decrease of the retention latency 3 of retention latency q gives an indicati
17. lated joints only The lack of sliding friction leads to a practically no wear b no backlash and hence silent operation and exact stroke reproducibility Hook up to animal Four ports Intake To Animal From Animal and Exhaust allow flexibility in air channelling The input may be room air or any non explosive gas mixture The exhaust air may be partially or totally re cycled or collected for analysis Ventilator Controls The speed control knob adjusts the geared motor to the desired speed which is indicated on the 3 digit LED di splay labelled STROKES P M The operation of Ugo Basile Ventilators may be pau sed by an external TTL logic signal Start Stop Model For more demanding electrophysiological pharmaco logical investigations in particular when the operation of the Ventilator is software controlled a synchronised command is available to START STOP the Ventilator at completed forced inspiration Ask for special models 6125 Specifications Rate 10 to 100 strokes for minute Rate Read out digital display Stroke Volume 10 to 50 20 to 100 depending on cylinder piston installed Stroke Vol Scale 10 50 ml Stroke Vol Reprod 2 Universal input 85 264 VAC 50 60Hz 40 VA max Physical Dimensions 27x26x19cm Net weight 10 5Kg Shipping Weight 16Kg approx Packing 67x42x53cm No 6025 Ordering Information 6025 CAT RABBIT VENTILATOR complete with following standard accessories
18. thus obtaining up to 12 spaces Operation The animal moves freely in one of the enclosure compart ments positioned on the testing surface After cessation of exploratory behaviour the operator places the touch stimulator below the target area of the animal paw using the adjustable angled mirror to position the filament The START key provided at both sides of the touch stimulator handle invokes the following automatic sequence a an electrodynamic actuator of proprietary de sign lifts a straight metal NiTi alloy filament b the small diameter rod touches the plantar surface and begins to exert an upward force below the threshold of feeling C the force increases at the preset application rate until a stop signal is attained either when the animal removes its paw or when the preset force is reached The filament 0 5mm diameter transmits force over the entire range of typical aesthesiometers Paw withdrawal reflex is au tomatically recorded using two metrics the latency until with drawal in seconds and the force at which paw was withdrawn in grams Basic Specifications Starting via keys on the touch stimulator vessel Force range 0 to 50 0 grams in 0 5g steps Force increasing rate adjustable in the interval 1 to 20 seconds in 1 s steps Filament travel 12mm Latency time on graphic display in 0 15 steps Connection to PC through DELTA 9 pin connector Data Acquisition The 37450 is a microprocessor co
19. 0272013 44 ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com Bronchospasm Transducer Cat No 7020 General This transducer is designed to perform the bron chospasm test on the guinea pig and is particularly suitable for connecting to UGO BASILE DataCapsu le Evo Recorder It enables the research worker to evaluate the Spasm inducing effect of drugs having a very wide range of action not necessarily intended to act on respiratory dynamics The Bronchospasm Transducer 7020 is also a useful research tool for screening substances inducing the opposite effect both those causing active broncho dilation in basal conditions and those which anta gonize test drugs such as histamine bradykinin etc It is basically an air flow meter provided with a wa ter input valve with adjustable pressure threshold The whole device is a compact unit made entirely of Perspex mounted on a base along with its own power supply and controls Main Features e Evaluates the bronchospasm inducing effect of drugs Simple and reliable method to assess airflow resistance The effect of bronchodilators agents is quickly assessed by simply connecting to an animal ventilator and to a data acquisition system or chart recorder 45 BRONCHOSPASM TRANSDUCER No 7020 Experimental Layout The experimental layout follows the well known Kon zett Roessler arrangement see BIBLIOGRAPHY with the anaesth
20. 39 0332744574 02 2015 60 ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com Learned Helplessness Cat No 40532 Rats Cat No 40533 Mice General When rodents are exposed to inescapable and unpredictable stress such as forced swim or ine scapable footshock they often develop deficits in memory and learning tasks e g Active Avoidance and they often show also analgesic reactions S I A Stress Induced Analgesia The Ugo Basile Set Up for Learned Helplessness is based on a sophisticated generator of unpredicta ble random shocks delivered to the grid floor of a rodent box where no escape is possible Electric shocks can be randomized in terms of shock length and interval Complex trains can be programmed Up to 4 animals can be treated simultaneously in 4 independent boxes controlled by the same elec tronic unit and software The set up for Learned Helpless is part of the new UB Behavioral Cage program exploiting the poten tiality of a modern controller with touch screen Main Features Ramdomizable shock patterns Maximum flexibility configure your own Experimental Schedules on the touch screen controller BEHAVIOUR CONDITIONING REWARD IDEAL TO STUDY Depression amp Stress New Model Learning amp Memory Impairment Stress Induced Analgesia S 1 A touch screen controller The new launcher application makes it po
21. 5 10 30ml VENTILATORS and GAS ANESTHESIA THE CHOICE OF THE CRITICS Quiet operation both acustically and electrically negligible R F broadcasting Reliable mechanics and impeccable finishing lifelong lasting Synchronised START STOP function available as optional Ugo Basile more than 10 000 citations RODENT VENTILATOR No 7025 Instrument description The unique linkage mechanism insures that 1 The piston almost touches the cylinder end with each stroke regardless of the pre set volume thus insuring all air taken into the pump is expel led with each stroke 2 The volume clearly indicated on a stationary dial is adjustable by means of a knob while the pump is either running or at standstill 3 The reciprocating motion is generated adjusted and transmitted to the piston by rods and articu lated joints only The lack of sliding friction leads to a practically no wear b no backlash and hence silent operation and exact stroke reproducibility Hook up to animal Four ports Intake To Animal From Animal and Exhaust allow flexibility in air channelling The input may be room air or any non explosive gas mixture The exhaust air may be partially or totally re cycled or collected for analysis Ventilator Controls The speed control knob adjusts the geared motor to the desired speed which is indicated on the 3 digit LED di splay labelled STROKES P M The ope
22. Cat No 57800 General The ECT apparatus is specially designed for neurochemical and neuropharmacological re search A constant current output is used which ensu res reproducible results and accurate determi nation of the EC threshold while also pinpoin ting any variations in the threshold brought about by drugs having a specific action on the cortex and subcortical regions The shock parameters have been selected af ter consulting the most recent literature to supply the most suitable range when opera ting with mice and rats Consistent reproducible current levels are produced by feedback circuitry that adjust for variance in impedance of the contact from animal to animal The Electroconvulsive Device is supplied with auricular ear lobe electrodes Particularly useful for MISCELLANEOUS ECT LMD DESIGNED FOR INDUCING CONVULSIONS IN RESEARCH ANIMALS General screening of potentially neurotropic substances FOR NEUROCHEMICAL amp NEUROPHARMACOLOGICAL RESEARCH Evaluating the depressant or stimulating action of drugs on the CNS Endocrinological investigations on the relationship between the nervous system and the hypophysis Ugo Basile more than 10 000 citations ECT UNIT General Consistent reproducible current levels are produced by feedback circuitry that adjust for variance in impedance of the contact from animal to animal The impedance of the anima
23. E WP 008 1 U K E WP 008 2 U S 52010 323 USB connector E AU 042 Individual Power Supply ACCESSORIES 41700 043 Combination vertical horizontal sensors for activity detection in metabolic cages 41800 302 Instruction Manual for Hardware SOFTWARE 51800 Data Acquisition Software for up to 8 cages For recording of food liquid consumption and activity in cages series 41800 51800 302 Instruction Manual for the software UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 104 UD Jugo basile TRANSFORMING IDEAS INTO INSTRUMENTS METABOLISM FEEDING BEHAVIOUR www ugobasile com TO RECORD THE FEEDING i ivi BEHAVIOUR AND ACTIVITY Feeding amp Activity USB Connection endive _ OPTIONAL IN RODENTS AND 4 nay THEIR ALTERATION BROUGHT Cat No 47552 47553 47555 ar K General The recently available animal models for example obese and diabetic mice exhibit symptoms similar to those in hu mans Model organisms are closely monitored revealing differences which can be correlated with those of the human disorders in fundamental parameters as feeding drinking quantity amp frequency of food drink uptake activity with optional I R motion detectors The Analyser basically consists of an Animal Cage which can be provided with optional activity detector and an Electro nic Unit 7 Te M l La This system has proved to be of gr
24. Information 40500 001 Touch Screen Controller amp Shocker 47500 010 Learned Helplessness Software and acti vation 47502 Rat Cage complete with electrified floor amp catch pan 47503 Mouse Cage complete with electrified floor amp catch pan 40500 005 Expansion Box for multiple cage set up Specifications Power Requirement 115 230V 50 60Hz 30W max Shock Parameters constant current from 0 1 to 2 9mA in 0 1mA steps Manual or external operation via 5V TTL signals with optio nal I O box 46000 150 Physical Weight 2 7 Kg 40500 001 5 3Kg 47502 3 2Kg 47503 Shipping Weight Akg 40500 001 9Kg 40552 6Kg 40553 Packing 80x60x44 control unit and one cage Bibliography Borsini amp Cesana Mechanisms of action of flibanserin in the learned helplessness in rats European Journal of Pharmacology 433 81 89 2001 Grau et alia Long term analgesia and activation of the Opiate system Science 213 1409 1411 1981 Guilherme dos Santos et alia Antidepressive like effects of electroacupuncture in rats Physiology amp Behavior 93 155 159 2008 Kademian et alia Biphasic effects of adrenal steroid on learned helplessness behavior by inescapable shock Neuropsychopharmacology 30 58 66 2005 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 02 2015 62 www ugobasile com Conditioned Place Preference Box CPP Cat No 425
25. Optional 0 5 ml cylinder piston as sembly VENTILATORS and GAS ANESTHESIA Unique Design Reliable Compact Silent Purely mechanical with impeccable finishing lifetime lasting Quiet operation and negligible electrical noise Ugo Basile more than 10 000 citations MOUSE VENTILATOR The instrument is compact and light cm 20x13x18 5 and 2 5 Kg and it is self contained in other words it embodies its power supply which feeds the geared mo tor its feedback controller and the rate display The Connection Square 1 Room Air 4 Expired Air 2 To lungs tae 3 From lungs As illustrated in the drawing above and pictured below a connection square of four ports include intake of air or other non explosive gas mixture delivery of air to the animal lungs return air from animal oe iS exhaust for sampling partial recycling testing positive expiration pressure etc so closely packed that the connection tubes are cut in different lengths to ease the insertion of the tubing Start Stop Model A Mouse Ventilator version is available Cat 28125 which embodies a controlled pause feature The synchronised START STOP function gives the ope rator a means to stop and restart the respirator at full lungs point via an external trigger pulse when it is beneficial if not essential to minimize any extraneous movement of the anesthetized animal during electro physiological recording
26. Weight Kg 15 0 approx Dimensions SS SS mena Packing dimensions 80x60x44cm Bibliography M Gerold amp H Tschirky Measurement of Blood Pressure in Una naesthetized Rats Arzneimittelforschung 18 1285 287 1968 M Gerold amp H Funfshilling Abh ngigkeit der Indirekten Blut druckmessung an Ratten von der Grosse der Kompressionman chetten Arzneimit telforschung 21 2071 2074 1971 Papers quoting Ugo Basile Model L Testai et alia The activation of mitochondrial BK potassium channels contributes to the protective effects of naringenin against myocardial ischemia reperfusion injury Biochemical Pharmacol 85 11 1634 1643 2013 A Kolosov et alia Intravenous Injection of Leconotide an Omega Conotoxin Synergistic Antihyperalgesic Effects with Morphine in a Rat Model of Bone Cancer Pain Pain Medicine 12 6 923 941 2011 M A Gouda et alia Synthesis and anti hypertensive activity of novel sulphadimidine derivatives Med Chem Res 21 11 3902 3906 2011 J Tchekalarova et alia Diurnal rhythms of spontaneous recur rent seizures and behavioral alterations of Wistar and spon taneously hypertensive rats in the kainate model of epilepsy Epilepsy amp Behavior 17 23 32 2010 C Bolego et alia Selective estrogen receptor a agonist provi des widespread heart and vascular protection with enhanced endothelial progenitor cell mobilization in the absence of ute rotrophic
27. X ray and imaging etc No 28025 Specifications Rate 60 to 300 strokes for minute Rate Read out on digital display Stroke Volume 0 1 to 1ml with standard 1 ml piston 0 05 to 0 5ml optional 0 5ml piston Reproducibility 2 Volume Scale precision engraved 0 05ml divisions Start Stop by synchronised command model 28125 only Power Requirements 115 or 230V 50 60Hz 10W max Physical Dimensions 20x13x18 5cm Net weight 2 2Kg Shipping Weight 4 6Kg approx Packing 40x39x30cm Ordering Information 28025 MOUSE VENTILATOR complete with fol lowing standard accessories 28025 010 1ml Cylinder piston assembly 28025 302 Instruction Manual on CD 28025 321 Perspex Vertical Lid 28025 323 Cannula Y connection assembly 0 7mm amp 1mm ID tube etc in a plastic case E WP008 Mains Cord Options 28025 5 Mouse Ventilator with 0 5ml cylinder piston assy amp standard accessories 28025 005 0 5ml Cylinder piston assembly 28125 Mouse Ventilator with synchronised START STOP feature with 1ml cylinder piston assy amp standard accessories 28125 5 Mouse Ventilator with synchronised START STOP feature with 0 5ml cylin der piston assy amp standard accessories Bibliography M S Karbalaei et alia Impaired contractility and detrusor hypertrophy in cavin 1 deficient mice Eur J Pharmacol 689 1 3 179 185 2012 D Chen et alia Angiotensin Type 1A Receptors in C1 Neurons of the Rostral Ventro
28. a single one channel stimulator Adequate Voltage 45V enabling stimulation by field electrodes of most in vitro preparations Continuous Monitoring of the preset current flowing through each preparation 19 MULTIPLEXING PULSE BOOSTER Instrument Description The 3165 features High Power digitally adjustable constant current up to 800 mA Adequate Voltage 45V which enables stimulation by field electrodes of most in vitro preparations de scribed in the literature Unipolar or Bipolar Mode Independent Isolated Circuits to eliminate interfe rence Continuous Monitoring of the preset current flowing through each preparation The current level of each channel is set via its individual 3 digit thumb wheel switch The current output is adjustable in each channel to equal or different levels in the range 0 799mA in 1mA steps These current levels are independent of the Stimula tor output voltage The pulse mode either unipolar or bipolar can be se lected on one or more channels Optional Timer An optional Timer Cat 3175 can be supplied housed in its individual mini box to enable the Pulse Booster to deliver pulse trains when the Stimulator lacks this feature This timer is provided with both train and pause between trains duration adjustments Both adjustment time scales span the interval 0 999 seconds in 1 second steps A standard field electrode pair Cat 3160 can be sup pl
29. animal cages Silent and automated sliding door to di vide the two compartments no stepping motor Reliable tilting floor detection mechanism EFFICIENT RELIABLE gt INSTRUMENT FOR THE CLASSIC PASSIVE Multiple Cage Set up AVOIDANCE TEST Step Through Cage NEW on the 2014 version The new launcher application makes it possible to manage other UB behavioral cages with the same Touch Screen Controller 40500 001 just purchase the hardware and the application software for the addi tional test Remote Control feature will make remote service and software upgrades extremely simple 57 PASSIVE AVOIDANCE Step Through Instrument Description Different set ups depending on animal rat or mouse and number of cages can be obtained by combining the following elements Programming Recording Unit with Shocker Rat Cage up to 4 with one controller or Mouse Cage up to 4 with one controller Expansion Box for multiple cage set up Programming Recording Unit The 40500 001 Programming Recording Unit encom passing all controls incorporates a constant current high precision 8 pole shocker and manages data acqui sition data are stored inside the unit and can be down loaded via the USB key provided as standard for further processing via Excel Access etc The Unit incorporating a 12 touch screen manages the Passive Avoidance Test via the 40550 010 Software
30. application of pressure directly to the joint Ugo Basile more than 10 000 citations PAM PRESSURE APPLICATION MEASUREMENT Rationale of the Technique Arthritis is associated with chronic debilitating pain in the joints Current metrics of arthritic pain in animal models are indirect by scoring the level of motor activi ty or the animal weight distribution Barton et al 2007 while correlating well with the level of joint pain their metric is a composite picture of complex pain respon ses and provides little direct information about local stimulation and locally evoked responses The quantification of localized joint hypersensitivity is not common in animal experiments in this sense the PAM device represents a step forward toward multifac torial measurement of pain related behavior in animal research the PAM is the first instrument designed spe cifically to apply force to the joint and automatically detect the animal response Instrument Configuration Pressure transducers the PAM device comes with 2 transducers each tested and validated Both flat and round the large transducer is suitable for rat the small one is ideal for mouse Fig 1 Joint Transducer An optional paw transducer applicator is also availa ble rapidly transforming the PAM into a Digital Randall Selitto for pressure application on paws muscles tail Fig 2 Paw Transduc Electronic Unit the compact PAM controller con
31. auxiliary systems pulse rate measuring and recording microprocessor controlled functions to self diagnosis calibration signal filtering signal storage Instrument Description Pressure is transmitted to the tail cuff as soon the cuff pressure exceeds the diastolic pressure and starts to nar row the tail artery the amplitude of the recorder pulse wave gradually decreases until the artery is completely constricted ischemic the graph becoming a straight line This point indicates the maximum internal pressure of the artery systolic pressure on the paper grid on which the actual pressure of the system is digitally printed in 10 mm Hg steps At the end of the recording a second pressure measure ment can be started with decreasing pressure The sy stolic pressure is indicated this time by the return of the pulse tracing The animal pulse rate can be assessed in real time by a pulse rate counter which picks the signal from the pulse transducer Main Features graphic printer graphic display analog output to digital recorders BLOOD PRESSURE VITAL FUNCTIONS INDIRECT MEASURING amp RECORDING OF THE SYSTOLIC AND DIASTOLIC PRESSURE IN UNANAESTHETIZED RATS amp MICE pulse transducers of superior performances analogue amp digital recording of all experiment phases reliable pressure generator providing smooth stepless pressure build up Ugo Basile more than 10 000 citations
32. basile 3EHAVIOUR CONDITIONING REV EAS IN 0 TRANSFORMING IDEAS www ugobasile com New Fear Conditioning System Series 46100 General The Ugo Basile Fear Conditioning Systems 46000 includes all the components to run experiments on mice or rats according to the paradigms Contextual Fear Conditioning Cued Fear Conditioning The detection of Freezing is automated and based on video analysis The shock light and sound pa rameters are controlled by software USB or ma nually via the new Electronic Unit based on touch screen technology System Configuration A typical Basic System consists of Controller with touch screen Animal box with electrified floor and Context Kit 3 floors 9 walls Isolation Cubicle with dual visible I R light Memory NEW MODEL speaker and fan all controls managed The complete system also include e by a single Freezing detection Software Behaviour Electronic Unit Oo USB Videocamera Preinstalled PC can be supplied as optional UO 1 Ge _ f Main Features NEW on the 2014 version AUTOMATIC detection of FREEZING also The new launcher application makes it possible to in Total Darkness manage other UB behavioral cages with the same Touch Specific versions for rats or mice and the application software for the additional test Remote Control feature will make remote service and software upgrades extr
33. cable Shipping Weight 0 4Kg Shipping Dimensions 46x38x2 7cm UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 100 03 2013 Jugo basile VITAL FUNCTIONS TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com MouseOQOx Plus Pulse Oximeter for Mice and Rats General The MouseOx is the world s first and only patented non invasive vital signs monitor for small laborato ry animals specifically designed for mice it can be used on larger rodents too The MouseOx and The MouseOx Plus are being used by over 1 500 researchers and veterinarians from Universities Pharmaceutical Companies and CRO It is fully controlled by PC with a user friendly in terface The new MouseOx Plus uses the same technology as the original MouseOx but also includes signifi cant improvements theenhanced signal processing ability improves response to the motion of conscious subjects the pulse signal is maintained and quickly re acquired following significant movement the modular software design allows the end user to purchase only the functionality that is needed _ Anesthetized Subjects SMALL measurement of core body temperature is now ANIMAL available Conscious Subjects the optional Multiplexer makes it possible to 3 VITAL SIGNS monitor up to 16 animals or 8 animals with 3 MRI Compatible MONITOR temperature using 1 MouseOx Plus Main Features
34. can be au tomated using the standard version of ANY maze so you only need a single piece of software to automate any of these tests additionally some devices such as our Fear Conditioning system are available with low cost ver sions of ANY maze specific to the device Simultaneous Testing Using ANY maze you can perform tests in up to sixteen pieces of apparatus simultaneously This provides a gre at way to increase throughput and also makes it easier to control for environmental variables And ANY maze s versatile camera management means you can use one camera or many to view the apparatus For example in these place preference boxes four came ras are being used one on either side of each box Cameras amp Computers With such flexibility how do you determine the compu ter cameras etc that you ll need The answer s provided by the ANY maze equipment wi zard which quizzes you about all the apparatus you want to automate and then creates a detailed report of the equipment required You can use ANY maze with inexpensive USB web cams high quality machine vision USB cameras DV camcor ders or almost any analogue CCTV camera This breadth of support not only makes it easy to find a compatible device indeed you may already own one but also means that the system can meet a range of differing requirements such as low cost notebook con nectivity simultaneous capture from multiple cameras tracki
35. closed wall height 15 height from the floor 60 Elevated Plus Maze Rat arm lenght 50 arm width 10 closed wall height 40 height from the floor 60 Zero Maze Mouse diameter 55 corridor width 5 wall UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 height 15 height from the floor 60 cm Y maze T maze These mazes have a metal base painted in non reflec tive grey more colors on request and plastic arms that can be disassembled and closed with the included do ors Dimension cm Y maze Mouse arms length 35 width 5 wall height 10 Y maze Rat arms length 50 width 10 wall height 20 T maze Mouse stem lenght 35 arm lenght 30 width 5 wall height 10 T maze Rat stem lenght 50 arm lenght 40 width 10 wall height 20 lt Open Field Open Fields are avaiable in non reflective grey color for mice 44 cm or for rats 100 cm both versions have de tachable walls for ease of storage NEW Mouse Radial Maze The new Mouse Radial Maze is manufactured from high tech metal alloy and durable plastics to be as sturdy as possible A new automated model with retractable doors is also available Different colors are available all non reflective and arms can be detached for easy cleaning Dimension cm arms length 35 width 5 wall height 10 Ordering Information 40125 Water Maze 120 cm for mice 40155 Water Maze 150 cm for mice and rats 40185 Wate
36. customer s request AOM 01010 Ordering Information 53500 Lesion Making Device standard package including 53500 310 Set of 3 output plugs 53500 302 Instruction Manual E WP 008 3 Mains Cord Technical Specifications from 10 uA to 99 mA timed between 1 amp 99 seconds or manually controlled Compliance Voltage 200 V DC Max Electrode R 20M0 10A down to 2KQ 100 mA Current Range Pulse Duration Mains Supply 115 or 230V 50 60 Hz Power Consumption 20W max Physical Dimensions 25x oxen Weight 1 5Kg Shipping Weight 2 8Kg approx Packing 45x34x26cm Bibliography S Stroobants et alia PIncreased gait variability in mice with small cerebellar cortex lesions and normal rotarod performance Behav Brain Res 241 32 37 2013 L B Cruz et alia PraEffect of the bone marrow cell transplantation on elevated plus maze per formance in hippocampal injured mice Behav Brain Res available online Apr 2013 M B Gomes et alia Glucose levels Observed in Daily Clinical Practice induce Endothelial Dy sfunction in the Rabbit Macro and Microcircula tion Fund amp Clin Pharmacol 18 3 2004 C Hamani et alia Bilateral Anterior Thalamic Nucleus Lesions and High frequency Stimula tion Are Protective against Pilocarpine induced Seizures and Status Epilepticus Neurosurgery 54 1 191 197 2004 J Lee and J J Kim Differential Effects of Cere bellar Amygdalar and Hippoc
37. flow rates and vascular tensions in a hagfish Comparative Biochemistry and Physiology C 150 45 49 2010 G Froldi et alia et alia Activity ofsapfrom Croton le chleri on ratvascularand gastric smoothmuscles Phytomedicine 16 768 775 2009 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 03 2013 84 SF ugo basile IDEAS INTO INST www ugobasile com isotonic Transducer Cat No 7006 General The 7006 Isotonic Transducer basically consists of a carbonfibre lever arm which pivots on the shaft of a Hall effect rotary motion transducer of original design The arm is balanced by an adjustable counter weight of tungsten alloy It is possible to carry out experiments on extreme ly small muscle fibres which can be held under a tension of as little as 100 200 mg so that minimal force and consequent displacement alterations can be recorded The lever arm balancing is provided by a tungsten alloy counterweight which can be shifted by tur ning its knurled section This load is monitored by the counterweight rim moving along a scale calibrated in grams Main Features The picture shows an Isotonic Transducer left amp an Isometric Transducer right see feparate datasheet Also available from Ugo Basile Tissue Baths 1 2 4 chambers Digital Recorder DataCapsule Evo Electrodes amp Stimulators Ugo Basile Isotonic Transducer is specially de
38. may also be attached to monitor the animal s locomotion The cage complies with the IACUC space requirements for mice Ordering Information 47552 00 MONITORING CAGE for Food amp Drink for RATS up to 150 grams complete with food amp liquid intake detectors and amplifier module 41800 010 Dimensions of the cage cm 35 4 x 23 x 18 cm 47552 002 47552 002 SAME FOR RATS 150 TO 300 grams SAME FOR RATS OVER 300 grams 475453 MOUSE MONITORING CAGE for Food amp Drink complete with food amp liquid intake detectors and preamplifier module 41800 010 Dimensions cage cm 28 6 x 20 x 15 5 cm 47555 GAS METABOLISM CAGE FOR MICE Each cage is provided with E WP008 Mains Cable Europe 52010 323 USB connector E AU 042 Individual Power Supply ACCESSORIES 7435 Set of horizontal activity sensors for 47552 7436 Set of vertical rearing sensors for 47552 41700 043 Combination vertical horizontal activiy sensors for 47553 47555 47552 302 Instruction Manual for the Hardware SOFTWARE 51800 Data Acquisition Software for up to 8 cages For recording of food liquid consumption and activity in cages series 41800 51800 302 Instruction Manual for the software UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 106 l ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com New Microwave Brain Fixation System Cat MMW 05 5kW General In neurochemical studies of the brain i
39. not without limitation In addition neither method has been extended to investigating behavioural responses to hyperalgesia The Plantar Test represents a remarkable advance in methodology as it combines the best features of all other methods of measuring pain sensitivity Unique to the Plantar Test the animal is unrestrained and unhandled during experi ments Main Features Automatic detection of paw with Modular animal enclosure from 3 to 12 spaces drawal no visual score needed conveniently designed to restrain mice or rats R intensity adjustable in the Optional 37300 Radiometer for calibration interval 01 99 in one digit steps Data portability via the included memory key Software included NEW orofacial stimulation by optional holders Ugo Basile more than 10 000 citations PLANTAR TEST Hargreaves s Apparatus No 37370 Instrument Description The Instrument basically consists of e aMovable I R infra red Source e aController the picture shows the optional printer 37000 145 mounted on the top panel e a Glass Pane supported by columns on a base platform onto which the movable source glides e amodular enclosure of new design in which the 3 Spaces can be further divided into 2 or 4 by removable partitions obtaining up to 12 spaces After the acclimation period the I R source placed un der the glass floor see the picture is positioned by the operator directly beneath
40. on the market Ask for details 47800 COMBO PACKAGE FOR MOUSE amp RAT If you plan to work with both rats and mice you should consider the Combination Package 47600 Mouse 47700 Rat Rota Rod offe red at a special price oo 47700 Rat Rota Rod a No 47600 Ordering Information 47600 MOUSE ROTA ROD standard package including 47600 320 Trip Plate complete 5 pieces 47600 321 Transmission Belt 2 pieces 47600 302 Instruction Manual on USB key 52050 07 Dedicated Software Package on USB 52050 322 Serial Cable 52010 320 Serial to USB adaptor E WP008 Mains Cord Optional 57145 Thermal Mini Printer 47800 Combination Package 47600 Mouse Ro ta Rod and 47700 Rat Rota Rod Physical Universal input 85 264 VAC 50 60 Hz Dimensions 40 w x30 d x38 h cm Weight Kg 6 0 Shipping Weight Kg 12 0 approx Packing 66x50x63cm Bibliography Method Papers N W Dunham amp T S Miya A Note on a Simple Appara tus for Detecting Neurological Deficit in Rats amp Mice J Am Pharmaceut Assoc Scientific Edit XLVI No 3 1957 BJ Jones amp DJ Roberts The Quantitative Measure ment of Motor Incoordination in Naive Mice Using an Accelerating Rotarod J Pharm Pharmac 20 302 304 1968 Papers Dealing With Rota Rod Technique B J Turner et alia Overexpression of Survival Motor Neuron Improves Neuromuscular Function and Motor Neuron Survival in Mutant SOD1 Mice Neurobi
41. raised during probe tests Probe tests run with the use of a lift platform give more reliable indications on the presence of true spatial learning The Ugo Basile Atlantis Platforms are made of clear Perspex and are operated by hydraulic pressure No electricity is pre sent inside the pool the electrical parts of the mechanism i e the electro hydraulic actuators are safely located outside Main Features 4 Platforms with one Controller Consistency of positioning in the 4 quadrants Remote lifting lowering control No more hands in the pool Manually or PC Operated No Electricity in the pool Ugo Basile more than 10 000 citations HYDRAULIC ATLANTIS PLATFORMS for Water Maze Experiments System Description Up to 4 platform motor combination connect to the 4 channel control unit Each platform is driven independently so that the Wa ter Maze experiment can be completely automated by positioning a platform in each of the 4 quadrants of the pool Once the 4 platforms have been positioned in the pool each is connected to the related external motor via the connectors conveniently fitted to the water tank ask for information about our models the whole experi ment can then be run automatically via the control unit or external triggers Specifications e 4independent channels manual or TTL mode e Platform vertical range 25 35cm e Vertical travel 10cm in 9 steps e Platform Speed 10m
42. remains in the interval 18 23 C Data Acquisition The 35100 is a microprocessor controlled unit The ex perimental data stored in its internal memory can be directly exported to the PC USB or serial ports Communication is managed by the dedicated CUB Data Acquisition Software Package Cat 52050 11 included as standard this Windows based Software enables the user to route to the PC the data originated by UB in struments and store them into individual files ready to be easily managed by most statistical analysis packages available on the market The 35100 is provided with a memory key to record all the experimental data of one or more sessions and to program the experiment layout from a remote PC Options An auxiliary conventional Hot Plate 35100 002 is available as optional for connection to the 35100 with the same operational features of a complete Hot Plate powered and controlled by the main unit Model 35200 Thermal Escape device is also available the 35200 encompasses a Hot Cold Plate an auxiliary Hot Plate and an interconnecting corridor to perform Temperature Preference Tests see figure below an ete e eee ee Pana wea Ordering Information 35100 HOT COLD PLATE standard package including 35100 001 Cabinet controller display and Plate assembly 35100 286 Perspex Animal Restrainer for Mice and Rats 25cm height 35100 302 Instruction Manual on USB key 3721
43. software Physical 40100 40400 Weight Kg ii 30 Shipping Weight Kg 7 39 Packing cm 80x60x44 x2 Bibliography R I W Spooner et al The Atlantis Platform A New Design and Further Developments of Buresova s On demand Platform for the Water Maze Learn Mem 1 203 211 1994 G Riedel et al Reversible Neural Inactivation Re veals Hippocampal Participation in Several Memo ry processes Nature Neurosc 2 10 898 905 1999 Q Wihshaw et al The Behavior of the Laborato ry Rat A Handbook with Tests Oxford Univ Press USA 1 2004 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 03 2013 70 ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com http ub anymaze com ANY maze Advanced Videotracking Cat No 60000 General ANY maze is a flexible video tracking system de signed to automate testing in behavioural expe riments Packed with advanced features ANY maze is one of the most comprehensive video tracking sy stems available today Flexibility With a single ANY maze system you can easily au tomate a range of apparatus for example a plus maze a water maze and a set of 6 locomotor acti vity boxes User friendly interface and flexibility Compatible with most cameras and digitizers BEHAVIOUR MAZE TRACKING ANY maze 1 Water maze example Ge Edt Qptors Heb e Bl2 4 wl A t S 9a N 0000 T
44. the start but ton It s that fast and simple Your settings are permanently stored in memory there s no need to re enter them each day Ordering Information N of nee Sitges e me o EC po Infusion 3x15 3x14 2 00 i 2 Infusion 28x23x14 4 00 Witdrawal Infusion Multiple 28x30 5x14 4 25 Witdrawal Infusion 4 28x23x15 3 4 00 different size Kos 260 Pushpa 242 sasaa as Nano 1 2 items 2 00 Pump Models KDS 100 amp KDS 120 Model KDS 101 Syringe Minimum Maximum Models KDS 200 220 KDS 210 230 KDS 250 260 syringe minimum Maximum top 0 008 ih 21 1 plimin C asw 0 003 53 15 pl min sour 0 005 wy 105 8 lin 100 nr 0 009 ih 212 6 iin C sou 0 021 wh 527 6 yin soo 0 042 wh 1060 pimin tm 0 083 wh 2119 pimin C sm 0 288 wh 7360 p min O 5m oaan 634mm tom 0 828 wh 1270mm C om raaynm 27mm 30m 1 817 wh 2789mm C eom 2 757 wh a234mim UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 Jugo basile TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com Blood Pressure Recorder non invasive Cat No 58500 for Rats Cat No 58600 for Mice Cat No 58550 for Rats amp Mice General The BP RECORDER 58500 combines three main systems pressure generation pressure monitoring system apulse amplifier and athermal array analog amp digital recording unit with two
45. to be positioned in such a way to use the classic Plantar Test instruments for sti mulating the hindpaw as well as the areas innervated by the trigeminal nerve The picture above shows a Durham Holder positioned on a classic Ugo Basile Plantar Test Hargreaves device Rationale of the technique The Durham Holders have distinct advantages which make them ideal as accessories to the classical Hargre aves test and they represent a step forward toward a multifactorial measurement of pain related sensitivity in animal research They may appear similar to the classic Broome style ani mal holder however those animal restrainers are clunky made of clear acrylic and do not have stimulus apertu res so they could never be used for this stimulation Quantification of localized hypersensitivity is common in the clinic but not in animal experiments Durham Holder rearview Acknowledgements The Durham Holders were invented and validated at the Center of Biomedical and Life Sciences at Missouri State University specifically in the laboratory of Dr Paul Dur ham director of Biomedical amp Life Sciences and Profes sor of Cell Biology at Missouri State University Filip Garrett and Allison Overmyer performed the vali dations Prototypes were put together by Larry Vause Ordering Information 37100 Set of two Durham Holders for rats 37102 medium size 37103 large size Physical Weight 0 4 Kg two holders Gross w
46. to customize and expand the anesthesia system upgrading from a basic flowmeter amp vaporizer to a full system with induction boxes brea thing circuits with masks of any size switch valves mul tiple delivery systems active or passive scavengers etc The blue 4mm thick aluminum rack has a highly resi stant paint to protect against stains from aggressive anesthetic liquids amp solvents Two universal attachment blocks are mounted on the back to connect the device easily to any rail or mobi le floor model anesthesia rigs of sizes 25x8mm up to 35x10mm Digital Flowmeter The Ugo Basile Gas Anesthe sia System includes a uni que digital flowmeter Its wide flow range from 0 3 to 16 l min and fine resolution 0 1 I min gua rantees enough gas flow to anesthetize up to 6 animals simultaneously Small and large animals could be anesthetized with the same system virtually from mouse to horse Nose cone Masks with diaphragm Unlike many rodent masks available on the market the se masks incorporate a latex diaphragm which holds the rodent nose keeping the animal in correct position and ensuring a continuous positive flow of fresh oxy gen amp anesthetic The membrane also pro amp vides a positive seal redu cing the exposure of the user to anesthetic gases Available in several sizes Small Large Mice a Small Medium amp Large Rats Large Rodents Feline The picture shows a mo
47. vertical notched bars of stainless steel to which the ho rizontal vertical detecting systems 7435 and or 7436 can be fastened The 7435 consists of two facing blocks containing an I R array of emitters and respectively sensors to record the horizontal activity A similar system Cat 7436 whose height can be adjusted assesses the vertical ac tivity rearing Open field cages are also available in different dimen sions and colors ask for additional details Data Acquisition The electronic unit is microprocessor controlled and fe atures direct PC output Internally stored data can be routed via a 9 pin D type connector to the PC serial port RS232 Data output is managed by 52050 04 Data Acquisition Software Package Windows based which enables the research worker to store the data into individual files ready to be easily managed by most statistical analysis packages available on the market No 47420 Combination with ANY maze videotracking software is also possible to integrate the quantitative measure of general locomotor activity collected by our Activity cage with more detailed information about the animal activity Moreover the 47420 will add vertical activity rearing to videotracking data Ask for additional information Ordering Information 47420 MULTIPLE ACTIVITY CAGE standard package including following parts 7441 Electronic Unit 7433 Animal Cage 7435 Set of emitter receiver sensor
48. wa ams Sound 110s 14 68 20 2000r ADD MODIFY DELETE Light 12 85 15 05 20 ne E3 CAGE 4 basile V 1 0 1 14 9 22 2014 11 43 AM Power OFF The Unit incorporating a 12 touch screen manages the Passive Avoidance Test via the 40530 010 Software Up to 4 cages can be connected to the same Controller If more than one cage is connected an expansion box 40500 005 is required for each additional cage The trials can be configured via the TIMELINE feature entering the setting via the virtual keyboard trial num ber the acoustic visual stimulus delay shock intensity and timing of the different experimental sequences PS pre stimulus interval randomizable CS conditional stimulus interval US unconditional stimulus interval Active Avoidance Cage shuttle box Two types of cages are available 40532 designed for Rats dimensioned 57x27x30 h cm D 48x20x22 h cm 40533 designed for Mice dimensioned 47x18x25 h cm 1 D 38x9x17 h cm Both cages are provided with acoustic and visual con ditioning stimulators The reinforcement consists of an electrical stimulus applied to the floor bars of the cage by an incorporated 8 pole scrambling circuit No 40532 Rats 40533 Mice The cage is divided into two compartments intercom municating by an opening at floor level When the animal crosses the door the cage floor tilts thus operating a reed arrangement which cuts out all the stimuli or if
49. with 2 Ana log Flowmeters TEC 3 vaporizer for Iso flurane passive scavenger evac tubing Vaporizers for other anesthetic agents available on request Activated Charcoal Canisters No 21100 Multiple Output Delivery Systems PS 0529 02 Dual Diverter Manifold with humidifier see complete model 21200 PS 30 459 Multiple Animal Delivery System 6 Flow meters see complete model 21600 Multiple delivery systems for 2 3 4 and 5 animals available Anesthetic Scavenger and Evacuation PS 0581 00 F air filter activated charcoal canister PS 0581 01 F air filter pkg of 8 PS 0582 Evac Tubing for F air 1 8 m with 19 mm male x 22 mm female adaptor 21100 833 Active Scavenger System to remove the anesthetic agent by negative pressure to be be connected to an activated charcoal canister Heating Pads and Surgical Tables PS 0491 Rodent Workstation with heated surgical table and outlet for anesthetic removal In cludes connection tubing for Gaymar wa ter circulator not included PS 0766 Water Circulating Pump Gaymar TP702 adjustable from 10 to 42 C PS 0811 Heating Pads Delta Phase Isotherm pkg of 3 20x20x0 65 cm Maintains animal body temperature near 37 C up to several hours Ideal for NMR Other Recommended Accessories Fill Devices PS 0950 for Isoflurane PS 0951 for Sevoflurane gt PS 0949 for Halothane Physical 21100 Weight 8 5Kg Dimensions 26 w x18 d x24 h cm
50. 11 43 AM Power OIF The Unit incorporating a 12 touch screen manages the Learned Helplessness Test via the 40530 010 Sof tware Up to 4 cages can be connected to the same Controller If more than one cage is connected an expansion box 40500 005 is required for each additional cage The trials can be configured on the touch screen con troller entering the setting via the virtual keyboard train features shock and timing of the different expe rimental sequences The system includes a user friendly reporting software to collect visualize and manage data related to the de livered shocks his is especially important to analyze the randomized shocks and have full control on the perfor med stimulation Randomizer The Touch Screen controller is also a sophisticated ge nerator of unpredictable random shocks delivered to the grid floor of the cage Electric shocks can be randomized in terms of shock length interval and complex trains can be program med It connects to up to 4 cages AON 7A1010 Rat and Mouse Cage The dimensions of Rat Cage 47502 are 22x22x20 h cm Mouse Cage 47503 is dimensioned 17x17x20 h cm Both Cages include an electrified floor and a catch pan The electrical stimulus is applied to the floor bars of the cage and by an 8 pole scrambling circuit incorporated in the touch screen controller All necessary cables and connectors are included to make it a ready to use system Ordering
51. 34x28cm Shipping Weight 5 8 Kg approx Bibliography Method Paper F E D Amour amp D L Smith A Method for Deter mining Loss of Pain Sensation J Pharmacol Exp Therap 72 74 79 1941 Papers mentioning UB model 7 0 Lilius et alia The Mineralocorticoid Receptor Antagonist Spironolactone Enhances Morphine Antinociception Eur J of Pain online view 2013 J W Little et alia Spinal Mitochondrial Derived Peroxynitrite Enhances Neuroimmune Activation During Morphine Hyperalgesia and Antinocicep tive Tolerance Pain 154 7 978 986 2013 P J McLaughlin et alia The Mineralocorticoid Re ceptor Antagonist Spironolactone Enhances Mor phine Antinociception Eur J of Pain online 2013 T A Kosten et alia A Morphine Conjugate Vacci ne Attenuates the Behav ioral Effects of Morphi ne in Rats Progr in Neuro Psychopharmacol and Biol Psychiatry 45 223 229 2013 J Walsh et alia Disruption of Thermal Nocicep tive Behaviour in Mice Mutant for the Schizoph renia Associated Genes NRG1 COMT and DISC1 Brain Res 1348 114 119 2012 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 10 be ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com LR Heat Flux Radiometer Cat No 37300 General The Heat Flux I R Radiometer Cat 37300 has been designed to calibrate R sources in particular the classic T
52. 36x23x18 h cm of the mouse cage 26x20x17 h cm Activity Detection The coordinate ambulatory activity and rearing of the rodent on test can be me asured via the optional mo tion detector Cat No 7435 horizontal and 7436 ver tical rearing each consi sting of two facing blocks of I R arrays of emitters and sensors For cage 47453 the two sensors are replaced by Cat 41700 043 combining both horizontal and vertical sensors FEEDING amp DRINKING ANALYSIS Each cage comes with feeding and drinking scales and incorporates a preamplifier module Cat 41800 010 which directly connects to the PC USB port for compu ter processing The consumed food and liquid and the optional activity can be recorded directly into a computer at preplanned intervals The Cage Monitoring System CMS Software 51800 manages up to 8 cages The software acquires data and provides results related to partial and total food liquid consumption and to activity A PC with USB port is re quired Please refer to the software manual for additional infor mation Mouse Gas Metabolism Cage The 47555 Gas Metabolism Cage for Mice is an airtight box which has ports to allow monitoring a mouse s O consumption CO production VO and VCO via an ex ternal Metabolic Monitor to be purchased separately The cages are complete with scales to record food and liquid intake via the 51800 software Infrared activity arrays 41700 043
53. 5 303 Pedal Switch E AU 041 Memory Key E WP 008 Mains Cord 52050 11 CUB Data Acquisition Software Packa ge complete with USB Connection Ca ble Optional 35100 002 Auxiliary Hot Plate 35200 Thermal Escape Device complete 57145 Thermal MiniPrinter with connection cable Physical Universal input 85 264 VAC 50 60Hz Dimensions 25x37x47 h cm with restrainer Weight 7 0Kg Shipping Weight 9 6Kg approx Packing 65x34x28cm Bibliography e M Sakurai et alia Oxaliplatin induced neuropathy in the rat involvement of oxalate in cold hyperalgesia but not mechanical allodynia Pain 147 2009 165 174 e L Yu et alia Effects of calcitonin gene related pepti de 8 37 on withdrawal responses in rats with inflamma tion EJP 347 1998 275 282 e D Piomelli et alia Anandamide suppresses pain initia tion through a peripheral endocannabinoid mechanism Nature NSC 2010 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 02 2013 ugo basile PAIN and INFLAMMATION TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com Plantar Test For Rats AUTOMATIC Hargreaves Apparatus l _ MEASUREMENT OF THE For Mice ANIMAL RESPONSE Cat No 37370 General Determination of acute nociceptive thermal threshold in laboratory animals has primarily relied upon the tail flick and hot plate methods Although both methods are used frequently in pharmacological studies they are
54. 5 drive consists of a variable speed geared motor linked by a novel variable stroke mechanism to easily interchangeable cylinder piston assem blies In particular the 6025 can be equipped with 50 or 100ml cylinder piston assembly Its precisely regulated geared motor speed provi des the most accurate and reliable stroke rate con trol of any respirator available The operation of the 6025 may be paused by an external TTL logic signal The picture features a Rodent Ventilator 7025 together Best available TH E CHOICE OF with the 6025 for Cat Rabbit 3 Sta rl i ng TH E CRITICS Pumps l Main Features Interchangeable cylinder piston assemblies 50 and 100ml Quiet operation both acustically and electrically negligible R F broadcasting Reliable mechanics and impeccable finishing lifelong lasting Synchronised START STOP function available as optional Ugo Basile more than 10 000 citations CAT RABBIT VENTILATORS Instrument description The unique linkage mechanism insures that 1 The piston almost touches the cylinder end with each stroke regardless of the pre set volume thus insuring all air taken into the pump is expel led with each stroke 2 The volume clearly indicated on a stationary dial is adjustable by means of a knob while the pump is either running or at standstill 3 The reciprocating motion is generated adjusted and transmitted to the piston by rods and articu
55. 5 h cm make it suitable for use with mice Both boxes have a patterned door in the central wall 7 5x7 5cm in the rat 4x6 h cm in the mouse box Tactile Stimulation Patterned Floors One of the major keys to the success of a CPP experi ment is due to the design of the visual and tactile differ ences between the 2 compartments Ideally the 2 compartments should have clearly distinct contextual cues but should not determine any prefer ence in unconditioned animals SSS SS SSS See eee eT aoe ee ee oe SGT SSS e880 888 Given the importance of paw tactile sensitivity in ro dents while the design of commercially available CPP boxes has traditionally focused only on the wall patterns and colors the Ugo Basile CPP box includes 4 inter changeable floors with different patterns amp texture Four sets of floor grids and 3 sets of replaceable wall contexts striped checked and dotted are supplied with each box Rationale and outline of the procedure The CPP paradigm provides information on the rewar ding or aversive effects of visible and tactile contextual cues associated with drugs This technique has acquired great popularity in research studies involving addiction being much easier if com pared to drug self administration procedures No 42552 First the animal is conditioned to identify one of the two compartments with the drug experience Then the time spent in each compartments is measured
56. 52 for Rat Cat No 42553 for Mouse General The Ugo Basile Conditioned Place Preference CPP is a 2 compartment box to evaluate the abu se potential of substances and the motivational ef fects of drugs The 2 compartments differ for the wall color and patterns and for the floor patterns and texture Both floors and contexts floors are interchangeable so that the visual and tactile difference between the 2 compartments can be easily adjusted by the scientist In fact the CPP box includes the contextual cues required by the experimental paradigm each box includes 4interchangeble floors with square and circu lar patterns 3 sets of walls The new CPP box has been designed and optmized for visual scoring or for use with any video tracking software See www u b anymaze com Main Features Optimized for Video Tracking Specific models for rats or mice Designed for multiple cage systems IDEAL TO STUDY Drug Abuse Addiction e Interchangeable floors for tactile stimulation e NEW MODEL with interchangeable CONTEXTS Interchangeable floors provided for different patterns amp texture Walls in either compartment can be visually altered by replacing the context kit 63 PLACE PREFERENCE BOX Rat and Mouse Box The box 42552 is designed for tests on rats Its external dimensions are 60x30x30 h cm the box 42553 is similar to the 42502 but its dimensions 32x15x2
57. 6026 50ml Cylinder piston assembly complete 6027 Set of 2 Lip Seal Rings for 50ml piston 7032 Perspex Lid 7033 Lithium Grease Tube 7034 Set of 3 Hex Wrenches 2 2 5 3 mm 6044 Y Canula 6025 302 Instruction Manual on CD E WP 008 Mains Cord Other available models and accessories 6025 100 Cat Rabbit Ventilator as above 100ml 6029 Set of 2 Lip Seal Rings for 100ml piston 6025 150 Anesthesia Kit Models with synchronised START STOP feature 6125 Cat Rabbit Ventilator 50m 6125 100 Cat Rabbit Ventilator 100ml See also our Anesthesia Systems series 21100 featured in the picture together with a 6026 Ventilator The ideal match to our Ventilators Bibliography A Ahmed et alia Development of an In Vitro Model to Assess Deposition of Aerosol Particles in a Representative Replica of the Rat s Respi ratory Tract J of Aerosol Med 25 3 169 178 2012 L Monassier et alia Prevention by NMDA recep tor antagonists of the centrally evoked increa ses of cardiac inotropic responses in rabbits Br J Pharmacol 111 4 1347 1354 2012 Hoch et alia Modulation of the amplitude of y band activity by stimulus phase enhan ces signal encoding Eur J Neuroscience 33 7 1223 1239 2011 T Tchumatchenko et alia Ultrafast Population Encoding by Cortical Neurons J Neuroscience 31 34 12171 12179 2011 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574
58. 68 Papers Dealing With Rota Rod Technique L D C Mannelli et alia Involvement of a7 nAChR Sub type in Rat Oxali platin induced Neuropathy Effects of selective activation Neuropharmacology 79 37 48 2014 F Barthel alia Long term Application of Glycine Tran sporter Inhibitors Acts Antineuropathic and Modulates Spinal N methyl D aspartate Receptor Subunit NR 1 Expression in Rats Anesthesiology 2014 A De Visser et alia The Adjuvant Effect of Hypertension Upon Diabetic Peripheral Neuropathy in Experimental Type 2 Diabetes Neurobiol Of Disease 62 18 30 2014 J Wang et alia Comparison of Anticoagulation and Thrombolysis Treatments in a Rat Model of Superior Sagital Sinun Thrombosis Intl J Neuroscience posted online 2013 F E Padovan Neto et alia Anti Dyskinetic Effect of the Neuronal Nitric Oxide Synthase Inhibitor is Linked to Decrease of Fosb Deltafosb Expression 541 126 131 2013 C D Heldermon et alia Development of Sensory Motor and Behavioral Deficits in the Murine Model of Sanfilippo Syndrome Type B PLoS ONE 8 e772 2007 rocking UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 04 2014 30 ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com Mouse Rota Rod Cat No 47600 General The Rota Rod technique has been origina ted by a 1957 paper of N W Dunham and T S Miya and has pr
59. CORDER with accessories for RAT amp MOUSE Each BP Recorder includes as standard dedicated sof tware 52050 08 serial cable amp USB adaptor paper roll Available Pulse Pick Ups 58000 503 Pulse Pick up for Mouse diam 3 mm 58000 504 Pulse Pick up for Mouse diam 4 mm 58000 505 Pulse Pick up for Rat diam 5 mm 58000 506 Pulse Pick up for Rat diam 6 mm UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 58000 507 Pulse Pick up for Rat diam 7 mm 58000 508 Pulse Pick up for Rat diam 8 mm 58000 509 Pulse Pick up for Rat diam 9 mm Available Tail Cuffs 58000 606 Tail Cuff for Mouse diam 6 mm 58000 609 Tail Cuff for Rat diam 9 mm 58000 611 Tail Cuff for Rat diam 11 mm 58000 613 Tail Cuff for Rat diam 13 mm Available Holders 58000 343 Mouse Holder 30 mm D 58000 344 Rat Holder 40 mm I D 58000 345 Rat Holder 50 mm I D 58000 346 Rat Holder 60 mm I D 58000 348 Rat Holder 80 mm I D Optional 58000 840 Mouse Heater compl with 6 mouse holders 58000 845 Rat Heater complete with 5 rat holders of selec table D 58000 850 Rat Scanner complete with 5 rat holders of selec table D if diameter is not specified the 50mm size will be supplied pressure cuffs amp pulse pick ups are not included and should be ordered separately Specifications Pressure Range 50 to 290 mm Hg Power Requirements 115 or 230 V 50 60 Hz 25 W Weight net Kg 10 6 Shipping
60. DEAS INTO INSTRUMENTS www ugobasile com PAM PRESSURE APPLICATION MEASUREMENT Cat No 38500 General The new P A M Pressure Application Measure spare ment from Ugo Basile is a novel easy to use tool for measuring mechanical pain threshold in expe rimental joint hypersensitivity models in rodents The PAM device has been designed and validated specifically for the mechanical stimulation and as sessment of joint pain and therefore is especially useful in studying arthritis The PAM applies a quantifiable force for direct sti mulation of the joint and automatic readout of the animal response The operator simply wears on his her thumb a spe ieee cial force sensor specially designed to apply force FRssssst8s lt to rat and mouse joints and measures the force PPM which elicits the animal response normally limb withdrawal Each PAM device comes standard with two force sensors a large one useful for stimulating rat joints a smaller sensor recommended to test mice an op tional paw transducer applicator is also available to stimulate the animal paw Main Features Software included NEW 2014 release Maximum Applicable Force 1500g Resolution 0 1g PAIN and INFLAMMATION oe ee ae daa gt MECHANICAL PAIN THRESHOLD IN Joint Hypersensitivity Chronic Joint Inflammation Joint Pain Arthritis Automatic recording of Limb Withdrawal User controlled
61. KDS pumps routinely perform many of the tasks that other pumps make you do manually So you have more time for what s really important your research KDS pumps are engineered by the designer of the best selling laboratory syringe pump to ensure you of years of unsur passed accuracy and reliability In addition you ll find they are extremely simple to set up and use And surprisingly affordable Setup is as easy as Select syringe from displayed table Enter volume to be dispensed Enter flow rate then press start button It s that fast and that simple Ugo Basile more than 10 000 citations INFUSION PUMPS by KDS No 5000 Common to all models A simple menu driven set up without prin ted look up tables performs rate and volume con trol and automatic shut off Just set the volume you want dispensed Volume is tracked continuously on the LC display Then when the preset volume has been dispensed the pump shuts off automatically An alphanumeric display helps elimi nate reading errors Their easy to read display provides real time readings using both parame ters and values for clearer mistake free readings You can control KDS pumps in many different ways Built in TTL and RS 232C interfaces permit easy external control Operation 1 Find the syringe you use from the displayed table Enter its code number 2 Enter the volume to be dispensed 2 Enter the flow rate then press
62. M Pressure Application Measurement NEW SOFTWARE e VF Electronic VON Frey sicciesisscecesavenssiveatacerxnssusieeresencian NEW SOFTWARE WON Troy HINE arere n E EEEE EIEEE E AAE AE ETEA RS Orofacial Stimulation Test Hargreaves Method sesssssssssrrsssrrrrrsrrern Durham Animal Holders for trigeminal stimulation sses MOTORY COORDINATION GRIP STRENGTH ACTIVITY 47200 Grip Strength Meter oo ccccccccce cece cceceeeeeeeeeeeeeees NEW SOFTWARE 47420 ACUI Ce EEEE E ADAE E EET 47700 RARO RON rE A vices ene sxe ohtdeene aascnss dated ieee ees 47600 Mouse Rota Roqd ooooec coc cccccccecccccccces cee ceeucecseces cess vseeeeceecesecssieusececsescessvesseceeesveeseeeseesseeecs 43000 KOLOMO TOT marire EEE EEE EEE EEEIEE EE E AA AAA EAEE 6650 Hole BOO sroin eaei ATA AE EA A 1800 Activity Wheels for Rats oo cccccccccccccccccccceececceecescssusecessseeeeessuseeeseveseceessetevessvteeesenes 1850 Activity Wheels for Mice sesiee cr pce monercassheivetswenerevaveensspsetexsans erretedecsadaretansasseieersiorennteets VENTILATORS and GAS ANESTHESIA 28025 Mo se Ventilator seirrirrrrerrrrrinirs rrenen aia NEEE AER ERTES 8 7025 Rodent Ventilator serirosesiiyissranissr arra ESTE EEEE Ei 6025 SANT Ventilator ee eecsscecie uae tedeteseceeas mancmpaceeschetetesesetedessiedebeuegeasisnesenmmadionensteiecat 7020 Bronchospasm Transducer ciestsacsnisesatccmessatintssiinscereiannsav
63. O INSTRUMENTS Von Frey Hairs Hypersensitivity Semmes Weinstein Von Frey Filaments for Touch Cat No 37450 275 Touch Threshold Accacemant General Von Frey hairs named after the German physiologist Max von Frey 1852 1932 were been originally produced from animal and human hairs of different diameter nowadays they are nylon monofillaments the diameter determines the resistance of the monofilament to bending A filament is placed perpendicularly to the skin with slowly increasing force until it bends thereby determining the amount of force applied The Aesthesio set of 20 monofilaments is based on the Semmes Weinstein monofilament set but now features retrac table filaments to protect the filament and allow the evaluator to carry a few around in a pocket The set of monofilaments provides an approximately logarithmic scale of actual force and a linear scale of perceived intensity They have a long history of effective use in clinical settings and can be used to diagnose pathologies of hyper or hypo aesthesia Subsets within the set of 20 probes distinguish pa thologies on different parts of the body foot hand lip cheek etc LAL At TTT Individual filaments are also sold separately indivi dually Tt wo mw A P wr A m a ae ae re z5 AAAAAALEELLLLLLIT i TTT ttt TTT TULELULeb Ue Artt ITARE ALALLLLLIELLLL Lt VLLLALALLALLALLY ie ea amp th Y
64. R power flux in a matter of 3 4 seconds Note thermal capacity mass by specific heat on the heat propagates by radiation conduction convection Practical Clues The measure as previously mentioned requires only a few seconds The I R probe is positioned on the Tail Flick Plantar Test after the suitable adaptor is fitted on the threaded head of its heat sink The reading on the digital display gives the I R power output in mW per square centimetre The calibration if necessary of the I R radiation source is carried out by adjusting the supply current of the I R bulb see the instruction manuals of the Tail Flick and respectively the Plantar Test Ordering Information 37300 I R HEAT FLUX RADIOMETER Standard package including 37300 001 Heat Flux Meter complete with cable connector amp 9V battery 37300 002 Heat Flux Probe 37300 302 Instruction Manual on CD 37300 320 Probe Front Cover 37300 321 Adaptor for Tail Flick 37300 322 Adaptor for Plantar Test I A 073 Instrument case Physical 37300 complete standard package lodged in its case Dimensions 37x32x11cm Weight 1 5Kg Packing 46x38x2 7cm Shipping Weight 3 6Kg UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 02 2013 12 be ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS PAIN and INFLAMMATION www ugobasile com Mechanical ASSESSMENT OF gt Dynamic Plantar Stimulati
65. Shipping Weight 12Kg Packing 67x42x53cm UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332 744574 022013 49 UO ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com Anesthetizing Box Cat No 7900 rodents 7910 rabbits General Our Induction Boxes are conveniently dimensio ned induction boxes featuring a sliding lid They are made of Perspex and prove to be particularly useful to confine laboratory animals during ane sthetizing The 7900 for small rodents is dimensioned 25x13x13 h cm the larger model 7910 for rab bits is dimensioned 40x22x21 h cm The transparent acrylics permits the animal to be kept under constant observation Two tubing connectors of nickel plated brass are fitted into each end one located at the top of the box and the other at the bottom Any non explosive gas mixture can be used In case small quantities of liquid as ether or chloro form are used soak a cotton wool flock and place it in a small Becker in side the box For more demanding application and higher sa fety an airtight model with latch is also available see picture below Ordering Information e 7900 Induction box for small rodents 25x13x13 h cm ID 23x12x12 h cm 7910 Induction box for rabbits 40x22x21 h cm ID 38x20x19 h cm 2100 790 Airtight model with latch see picture 25x13x13 h cm ID 21x11x13 h cm UGO BASILE www ugobasile com sales ugob
66. Simple non invasive sensor clips USB plug and play user friendly interface for mice and rats High accuracy at heart rates up to 900 BPM Monitor data in real time while recording Works on neonates through adults Ugo Basile more than 10 000 citations MOUSEOX General The MouseOx Plus Small Animal Vital Signs Monitor pro vides the following measurements Arterial Oxygen Saturation Heart Rate Breath Rate Temperature optional Pulse Distention Breath Distention MouseOx Plus works with both mice and rats there are 16 variations of the MouseOx sensor available to ac commodate various sensor placement options on mice and rats ranging in size from neonatal mice to rats over 500gm The subject must have a heart rate of at least 90 BPM and no greater than 900 BPM The MouseOx oxygen saturation measurement has only been validated with mice and rats but the instrument is being used in many research projects on subjects other than mice and rats Some examples include Guinea pigs hamsters rabbits and small primates such as marmosets Cardiopulmonary Data Recorder When used as a Cardiopulmonary Data Recorder the MouseOx Plus provides Quick Check of Vital Signs Real time Changes in Heart Rate Breath Rate amp O2 Sa turation Oxygen Saturation During Hypoxemia Analog Data Output Surgery Monitor When used as a Surgery MonitorMouseOx Plus Prevents Hypoxia During Surgery Titrate
67. Sirri et al Temporal gene expression profile of the hippocampus following trace fear conditioning Brain Research 1308 14 23 2010 54 4 ugo basile ING ID Active Avoidance Set Up Automatic Reflex Conditioner General The new model of Active Avoidance Set Up has been designed to enable the researcher to perform a wide range of avoidance experiments each ac cording to a flexible schedule Via the TIMELINE feature the user will be able to configure a number of different tests according to the specific experimental needs namely the classi cal shuttle box tests in its various modes Ugo Basile Active Avoidance set up instrument ba sically consists of a Controller and a Cage for either rat or mouse The tests are conducted in a cage divided into two sections by a partition with an intercommunicating opening at floor level The tilting floor ensures a simple and reliable detec tion mechanism to score the animal s movement across the two compartments The electronic unit encompasses all controls for up to 4 cages and a scrambling shocker Main Features Maximum flexibility configure your own Avoidance Experiment Schedules via the timeline function The electronic unit encompasses all con trols for up to 4 animal cages Reliable tilting floor detection mechanism Multiple Cage L EFFICIENT RELIABLE NEW VERSION INSTRUMENT FOR THE CLASSIC ACTIVE AVOIDANCE TEST
68. Weight 11 5Kg ration side arm in 20 30 or 50 ml volume Tissue cham 3 Packing 80x60x44cm bers without hook are available on request 4400 Dimensions 47x29x22cm Control Box Weight 9Kg Shipping Weight 16 5Kg The control section of the bath lodges the electronics Packing Ap AA the temperature regulator the temperature sensor amp es the circulation motor are Power Requirement connected to by connec 115 or 230V 50 60Hz tors enabling quick di 3 250VA max for 4000 4050 400VA max for 4400 sconnection for servicing ik acta Bibliography The upper panel consoli N Bektas et alia Effect of phenolic acids on functions Se iene dates all commands and of rat aorta vas deferens and on metabolic changes in the temperature regula streptozotocin induced diabetes Indian J Pharmacol tor with keys to preset AA 2 184 188 2012 F ea water temperature in the A Rizzo et alia In vitro effects of L arginine on sponta A range 25 45 C enabling neous and Homocysteine induced contractility of pre an accurate temperature gnant canine uteris Theriogenology 76 4 715 720 ae k 2011 Bh uco sasne setting in 0 1 C steps E N Gorbatova et alia In Vitro Effects of Pentifin on Some Neurotransmitter Systems in the Brain Bull Ex per Biology amp Medicine1 36 2 174 175 2003 Ugo Basile offers a complete line of Transducers Iso G Re et alia Identificat
69. a Data Aquisition The 43000 is a microprocessor controlled unit The experi mental data stored in its internal memory can be directly exported to the PC USB port or to a flash drive included Communication is managed by the dedicated CUB Data Acquisition Software Package Cat 52050 13 included as standard The CUB Windows based Software Package enables the user to route the experimental data to the PC and store them into individual files to be managed by most Statistical analysis packages available on the market Ordering Information 43000 ROTOMETER standard package including 43000 001 Main Unit with display 35100 286 Perspex Animal Restrainer 25cm h 43000 302 Instruction Manual on USB key E E018 Paryline coated Magnet 2x12mm 2pcs E E019 Paryline coated Magnet 2x15mm 2pcs E AU 041 Memory Key 52050 13 CUB Data Acquisition Software Package and USB cable Optional 57145 Thermal MiniPrinter 43000 321 Syringe Kit incl implanter replacement nee dle amp injectable magnets 2x12 amp 2x15 mm 10 each 43000 012 Set of 10 Paryline coated Magnets 43000 015 Set of 10 Paryline coated Magnets 43000 052 Set of 50 Paryline coated Magnets 43000 055 Set of 50 Paryline coated Magnets 2x12mm 2x15mm 2x12mm 2x15mm a NOON ON Specifications Read out multifunction graphic display Print out by optional thermal MiniPrinter Universal Mains 85 264 VAC 50 60Hz 30 W max Dimensions 25 w
70. action FASEB Journal fj 09 139220 pub online 2010 98 07 2013 ugo basile BLOOD PRESSURE VITAL FUNCTIONS TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com Blood Pressure Easy to fill Transducer invasive Cat No 17844 Robust reusable High accurancy i Typical Applications Arterial or venous blood pressure Urodynamic measurement measurement Intrauterine Pressure Measurement aes Intracranial Pressure Measurement Connects to Data Acquisition Systems or Catheterizati Chart Recorders atheterization Intensive Care Unit Main Features MPG Klasse II b CE 0470 Short adapter cable with transducer separate monitor cable Gold plated for easier cleaning Dome with Snap on coupling Only wiping cleaning necessary Very high frequency response Disinfection Sterilisation with VIRKON High overload protection 10 000 mm Hg 10 to 30 min possible Dome dry coupled to the transducer Ugo Basile more than 10 000 citations Pressure Transducer No 17844 Specifications Compatibility Pressure Range 20 300mmHg 3 Before ordering check the connection compatibility of l your amplifier recording System Overpressure max 10 000mmHg Sensitivity 50 uV V cmHg The Pressure Transducers are normally supplied with a connector type F designed for Ugo Basile DataCapsule Resonance Frequency 300Hz typical Evo Recorder see datasheet Transducer and Dome
71. ail Flick 37360 and Plantar Test 37370 of our make The purpose of this extremely useful accessory is to make sure different I R sources deliver the same power flux expressed in mW per square cm hen ce a nociceptive stimulus of the same intensity The standard package of this portable self sufficient instrument includes an I R Probe a Digital Meter and Adaptors for Tail Flick and Plantar Test see pic ture all parts of neatly lodged in a sturdy plastic case with punched foam lining Main Features PAIN and INFLAMMATION e For Precise Calibration of Infrared Analgesia Meters O Provides a measure of stimulus intensity in mW cm e To calibrate the I R emission of Ugo Basile Plantar Test amp Tail Flick Assures that all infrared instruments are emitting the same level of stimulus intensity Ugo Basile more than 10 000 citations 7 L k I R HEAT FLUX RADIOMETER The I R output of a I R Tail Flick or Plantar Test may over the course of one two years undergo to 2 3 re duction due to dust gathered on the optics darkening of the I R bulb accidental knocks aging of components due to thermal cycles etc Moreover if the bulb is replaced or the electronics ser viced output alteration of more significant magnitude say 8 10 may take place The 37300 Radiometer enables the experimenter to Check and adjust if necessary the actual emission of an I R source Ensure that
72. alve The tissue in the chamber is washed by flushing the chamber through an over flow drain tube to avoid exposing the tissue to the air Water stirring is accomplished by a water jet delive red by a centrifugal pump A 200W stainless steel heating element is mounted on the Perspex tank floor A precise solid state pro 3 SAFETY 4000 One Muscle Chamber portional thermostat maintains the temperature within the excellent limits of 0 1 C on all models 4050 Two Muscle Chambers EFFICI ENCY 4400 Four Muscle Chambers Note the Isometric and Isotonic Transducers featured in the picture are not included and can be ordered separately Main Features e All components visible through the clear Pespex tank great for teaching Tissue washing without exposure to air Water jet bath stirring provided by a noiseless vibration free centrifugal pump Easy and quick mounting of tissue TRE ISOLATED ORGAN BATHS No 4000 4050 4400 Bath 4000 The 4000 water bath consists of a clear Perspex tank Ordering Information 19x19x17cm which contains one tissue chamber one 4000 Isolated Organ Bath One Muscle Cham temperature equilibrating coil one adjustable support ber with circulation pump heater ther rod on which transducers can be fastened to the tank mostat temperature sensor complete pro via the holder provided 3 vided with following standard accessories Bath 4050 3 4005 Temperature Equ
73. ampal Lesions on Classical Eyeblink Conditioning in Rats J Neuro science 24 13 3242 3250 2004 K C Bicego and L G S Branco Discrete Electro lytic lesion of the Preoptic Area Prevents LPS Induced Behavioral Fever in Toads J Exper Biol 205 3513 3510 2002 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 04 2013 92 MISCELLANEOUS ECT LMD TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com Stereotaxic Instruments by Stoelting Cat No 51600 General The Lab Standard Stereotaxic Instrument ma nufactured by Stoelting is ideal for researchers in need of a versatile reliable instrument for stereo taxic procedures with small animals Precision alignment when using the Lab Stan dard ensures accurate placement of electrodes micropipettes and other devices The time proven U Frame design concept stur i dy construction and adaptability to most model e species make this the best choice for a stereota A a xic instrument ACCESSORIES AVAILABLE FOR USE SLEEK COMPACT DESIGN WITH A WIDE VARIETY OF SMALL ANIMALS Classic and Proven U Frame Design Large easy to read vernier scales Scales are laser engraved accurate to 100 microns Triple lead screws for fast positioning 80 mm of vertical lateral and anterior posterior travel Absolute lock at 90 degrees vertical Brass bushings in manipulator arm permit electri
74. aneously When a mouse falls off its cylinder section on to the pla te below the plate trips thereby recording the animal s endurance time in seconds Height to fall is 16cm A large very readable backlit graphic display shows the actual angular speed RPM At the end of a run the di splay shows for each animal the running time and the instrument rotation speed at the time that animal fell off The panel can be oriented to select the most comforta ble angle for the operator to avoid glare etc The main features digitally preset by function keys are the following the angular speed can be preset in the range 2 80 RPM revolutions per minute in the acceleration mode the change of speed can be preset in 6 second 10 minute interval in 6 second steps reverse rotation can be selected which takes pla ce at minimum speed at the end of a pro grammable acceleration deceleration sequence a rocking motion is also presettable with adju stable angular amplitude speed and accelera tion Data Acquisition The 47600 is microprocessor controlled and features di rect PC output Internally stored data can be routed to the PC serial port RS232 or USB via adaptor provided Data output is managed by 52050 07 Data Acquisition Software Package Windows based which enables the research worker to store the data into individual files ready to be easily managed by most statistical analysis packages available
75. arrays for horizontal activity 7436 Set of emitter receiver sensor arrays for vertical activity 47420 302 Instruction manual on CD 37400 305 Package of 10 Heat Sensitive Paper Rolls E WP008 Mains Cord 52050 04 Dedicated Software Package CUB 52010 320 USB to serial port converter 52010 322 Serial cable 9 to 9 pin Physical Weight 7441 2 7Kg 7433 11 8Kg including 7435 7436 Dimensions 7441 27x16x19cm 7433 54x50x37cm Shipping weight 26Kg whole set up Packing 80x60x44cm Bibliography V Labrie et alia Genetic loss of D amino acid oxidase ac tivity reverses schizophrenia like phenotypes in mice Genes Brain and Behavior 9 11 25 2010 J Vlainic et alia Zolpidem is a potent anticonvulsant in adult and aged mice Brain Res 1310 181 188 2010 A Betourne et alia Central locomotor and cognitive ef fects of a NPFF receptor agonist in mouse Peptides 31 221 226 2010 A Marazioti et alia Somatostatin Receptors in the Ven tral Pallidum Substantia Innominata Modulate Rat Locomotor Activity Psychopharmacol 181 2 319 326 2005 W Ponti et alia In vivo Model for the Evaluation of Mo lecules Active Towards Transmissible Spongiform Ence phalopathies Veter Res Communicat 28 1 307 310 2004 T Dolezal et alia Guaifenesin Enhances The Analgesic Potency of Paracetamol in Mice Arch Pharmacol 366 6 551 554 2002 UGO BASILE www ugobasile com sale
76. asile com TEL 39 0332744574 VENTILATORS and GAS ANESTHESIA Our Induction chambers are ideal to work with our new Anesthesia Systems y TO CONFINE SMALL LABORATORY ANIMALS DURING ANESTHETIZING 02 2013 i z ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS BEHAVIOUR CONDITIONING REWARD www ugobasile com Touch Screen Controller for Conditioning Cages Cat No 40500 001 General The 40500 001 Touch Screen Controller is a powerful and versatile tool which will conomonna AVODANCE touch screen function as main unit in a number of tests controller Fear Conditioning see 46000 100 Passive Avoidance step through Passive Avoidance step Down Active Avoidance Learned Helplessness A SINGLE UNIT TO CONTROL _ EXPERIMENT SETTINGS LIGHT SOUND ETC For each test a specific application softwa re is available for installation each software 3 SHOCK PARAMETERS Startle Response PPI available soon is sold separately so it is easy to customize each controller DATA ACQUISITION MANAGEMENT amp EXPORT By the application Launcher UB installed IN ALL UB CONDITIONING CAGES on the 12 touch screen the user chooses the experimental routine among the ones installed Main Features The electronic unit encompasses all controls for up to 4 animal cages Thesame controller will function as main unit in a number of behavioral tests just
77. ated ei ther by the sudden release of the paw or by pres sing the external foot pedal The display then gives the operator a summary of the results of the test i e force and time corresponding to the animal re sponse The operator may choose to reject the results or to accept them in which case they are recorded in the e VF internal memory The results of several hundred tests may be stored in the e VF for transfer them to a PC when convenient The rate of application of the force is set by the operator and the NEW e VF includes software tools that help in consistently applying the force at the desired rate Main Features Software included NEW 2014 release Maximum Applicable Force 1000g Resolution 0 1g gt Sensitivity ASSESSMENT OF _ HYPERSENSITIVITY Allodynia INRATS amp MICE lt Automatic recording of animal response User controlled application of force rate Location of the target via the original prism design aie e VF ELECTRONIC VON FREY Rationale of the technique Impaired cutaneous sensation is usually first make evi dent as a loss of light touch detection The Electronic Von Frey was developed to quantify the sensitivity to light touch in the laboratory animal The classic instrument for test of touch sensitivity is the Semmes Weinstein set of Von Frey Hairs i e 20 monofilaments in a linear scale of physical force The Semmes Weinstein set can be used on rodent
78. ation The software collects the experimental data and saves them as csv file amp rpt file the latter a proprietary format which can be opened only within the Lickometer software A complete report file is pro vided at the end of the experiment results can be automatically printed and exported into a datasheet Ordering Information 45100 Lickometer Set up for RAT one cage including 45100 002 Rat Cage 45100 001 5 channel Electronic Unit 45100 005 Software 45100 004 Shocker 45100 302 Instruction Manual 45150 Lickometer Set up for MOUSE one cage 45100 003 Mouse Cage and other components as for 45100 Physical 45100 45150 Weight 8 5Kg 7 5Kg Packing 80x60x44cm 80x60x44cm Shipping Weight 12Kg 10Kg Bibliography P Ohara et alia Evidence for a Role of Connexin 43 in Trigeminal Pain Using RNA Interference In Vivo J Neurophysiol 100 3064 3073 2008 J P Vit et alia Silencing the Kir4 1 Potassium Channel Subunit in Satellite Glial Cells of the Rat Trigeminal Ganglion Results in Pain Like Behavior in the Absence of Nerve Injury J Neurosc 28 16 4161 4171 2008 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 06 2013 66 Jugo basile BEHAVIOUR MAZES TRACKING TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com Sociability Apparatus FOR STUDIES ON 3 chambered social test nutum Social Memory amp Novelty Pair bonding Dominanc
79. bly 37450 278 37450 278 Base Assembly for plantar stimulation incl supporting columns perforated metal sheet and multiple configuration animal enclosure from 3 to 12 spaces 20 1S Ww ugo basile PAIN and INFLAMMATION Orofacial Stimulation Test mechanical Nociception Trigeminal Fehrenbacher Henry and Hargreaves Method Thermal Nociception hype ral ges ia General The Orofacial Stimulation Test by Ugo Basile measures hypersensitivity to thermal or mechanical stimula tion of the trigeminal area Rats voluntarily contact a thermal or a mechanical stimulator with their unshaved vibrissal pad in order to ac cess a food reward Metrics obtained are the duration of feeding and the number of feeding attempts measured by interruption of an infrared barrier traversing the opening to the reward Feeding duration and number of attempts are strongly dependent on changes in the applied thermal or mechanical stimulus a Main Features Mechanical and thermal nociception assays within the same experiment High throughput up to 16 animals can be tested simultaneously Intact vibrissal pad as the test does not require any shaving The ORO Software included as standard manages up to 16 cages Ugo Basile more than 10 000 citations OROFACIAL STIMULATION TEST No 31300 Instrumentation and Methodology Orofacial pain problems are common and involve struc tures and mechanisms unique to the trigeminal nerve Few
80. cal grounding Ugo Basile more than 10 000 citations Stereotaxic Instruments Stoelting s Lab Standard offers several advantages over competing instruments Easily Read Scales All scales are oriented to be read easily from the open end of the U This is the position from which most scientists prefer to work The numerals on the scales are larger and therefore more easily read The scale li nes are laser engraved to allow finest possible perma nent marking of scales on all 3 axes Precise alignment with facing vernier scales gives accurate resolution to 0 1mm Smooth Movements The Lab Standard s exclusive triple lead screws allow the fastest positioning possible consistent with lining up the scales easily at a given coordinate Versatily of Positioning The manipulator arm controls medio lateral and ver tical positioning via lead screws and antero posterior movement via dovetail slide movement with 80 mm of travel possible in each direction A Universal Joint al lows the investigator to change the angle of the probe up to 90 in either the antero posterior or medio lateral planes The improved locking mechanism on the Lab Standard will hold any angle position without slippa ge And of course it also provides an absolute lock at 90 vertical In addition a swing joint allows the investigator to con veniently swing the manipulator arm and probe out of the way for performing a procedure
81. cation Measurement Plantar Test Hargreaves Apparatus Plethysmometer Tail Flick Unit Orofacial Stimulation Test Fehrenbacher Henry Hargreaves method ALLODYNIA HYPERSENSITIVITY Dynamic Plantar Aesthesiometer Von Frey Hairs with grid SOMATOSENSATION Hotes ele P A M Pressure Application Measurement e VF Electronic Von Frey Durham Animal Holders Mouse Rat Rota Rod Rotometer Activity Cage Isolated Organ Baths Mouse Open Field 44cm Grip Strength Meter mice and rats Hole Board MOTOR FUNCTION PARKINSON S STRENGTH EXERCISE Blood Pressure Recorder non Invasive Blood Pressure Transducer Invasive Cat Rabbit Ventilator Gas Anesthesia System Mouse Ventilator Pulse Oximeter for Mice amp Rats VENTILATION ANESTHESIA SURGICAL MONITORING NEW Fear Conditioning System Atlantis Platforms for Water Maze Passive Avoidance step down NEW MODEL Any maze Video Tracking Software Water Maze Pool Barnes Maze Mouse Open Field 44cm Passive Avoidance Step through New Model Multi Maze System for Mouse Active Avoidance Set Up Shuttle Box MEMORY LEARNING ALZHEIMER Sociability Apparatus 3 chambered social test NEW Place Preference CPP KDS Infusion Pumps Any maze Video Tracking Software Lickometer Vogel Test Mouse Open Field 44cm ADDICTION AND REWARD SOCIAL BEHAVIOUR AND AUTISM Learned Helplessness Activity Cage Any maze Video Tracking Software Lickometer Vogel Test Elevat
82. cient method invol ves minimal stress for the animal and has the advanta ge of requiring no anesthesia procedure Fig 1 2x15mm magnet attached to the mouse tail Our magnets are encapsulated within a proven bio compatible material Paryline to be implanted or in jected subcutaneously and fit within syringes normally used for the injection of identification transponders i HHL ii o Ue Fig 2 four Rotometers set up for high throughput screening for testing several animals at the same time Principle of Operation The animal is placed in the open field 20cm diam cir cular arena enclosed in a 25cm tall acrylic cylinder Our Rotometer is dimensioned for mice but small rats can also be tested conveniently The design of this detecting system is very advanced to enable the arena to be quite large whilst the ma gnet aboard is very small UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 When the mouse circles within the open field or rotates in place the magnet carried by the mouse also rotates Sensors below the open field pick up these rotations and the electronics record their number over time discrimina ting Clockwise from Counterclockwise rotation As CW and CCW rotations accrue they are displayed on the front panel and stored in the instrument internal memory experiments may be qualified with animal data date time and other diagnostic dat
83. cluding upper amp lower cham bers valves set of tubes etc 14900 004 Suction Pump 14900 302 Instruction Manual 14900 328 Set of Phials 14900 338 Set of Filters 14900 325 Phial Rack 14900 302 Drain Pan E WP008 Mains Cord Optional 14900 003 Water Circulator Heater 14900 015 Masterflex Peristaltic Pump 12 chan nels expandable 14900 024 Masterflex Peristaltic Pump 24 chan nels No 14900 Physical Weight 34Kg complete assembly Shipping Weight 48Kg 14900 001 38 w x30 d x13 h cm 14900 002 46 w x28 d x60 h cm Packing 1 box 80x60x44cm 1 box 62x65x84 Dimensions Power Requirement 115 or 230V 50 60Hz 100W max Bibliography Method Paper M Raiteri F Angelini G Levi A simple apparatus for studying the release of neurotransmitters from synap tosomes Eur J Pharmacol 25 411 414 1974 Papers quoting 14900 A Pittaluga et alia Effects of the neoclerodane Hardwi ckiic acid on the presynaptic opioid receptors which modulate noradrenaline and dopamine release in mou se central nervous system Neurochemistry Intl 62 4 354 359 2013 S Zucchini et alia Increased excitability in tat transge nic mice Role of tat in HIV related neurological disor ders Neurobiology of Disease available onlyne 2013 F Giribaldi et alia Group metabotropic glutamate au toreceptors induce abnormal glutamate exocytosis in a mouse model of amyotrophic lateral sclerosis Neuro p
84. conds can be set in steps of 1s Ordering Information 40500 001 Programming Recording Unit amp Shocker 40570 010 P A Software and activation 47573 Mouse Cage complete 2 platforms 40500 005 Expansion Box for multiple cage set up Specifications Start from the touch screen or via pedal switch Stop from the touch screen or via pedal switch Vibration 10 100HZz in 10 steps 10Hz each Shock 0 to 3mA in 0 1mA steps Delay 0 15 seconds in 1s steps Latency Time 0 1s steps Physical Dimensions 28 w x23 d x26 h cm Cage Dimensions 33 w x25 d x5 5 h cm Control Unit Weight 8Kg Shipping Weight 16Kg approx Packing 80x60x44cm Bibliography Papers which quote the P A Test step down A Mikulecka et alia Consequences of early postnatal benzodiazepines exposure in rats Cognitive like be havior Front Behav Neuroscience 8 101 2014 K Celikyurt et alia Effect of harmane an endogenous B carboline on learning and memory in rats Pharma col Biochem amp Behavior 103 666 671 2013 DS Dimitrova amp D P Getova Spassova Effects of Galan tamine and Donepezil on Active and Passive Avoidance Tests in Rats With Induced Hypoxia J Pharmacol Scien ces 101 199 204 2006 M Sakaguchi et alia Effects of beta casomorphin 5 on passive avoidance response in mice Biosci Biotechnol Biochem 67 11 2501 2504 2003 UGO BASILE www ugobasile com sales ugobasile com TEL
85. d store them into individual files to be managed by most Statistical analysis packages available on the market The 37360 is provided with a memory key to record all the experimental data of one or more sessions and to program the experiment layouts from a remote PC Calibration Radiometer Each Tail Flick Unit is accurately calibrated via an Heat Flow I R Radiometer Cat 37300 The end user should consider this extremely useful ac cessory which enables the experimenter to i Make sure that two or more units deliver thermal nociceptive stimuli expressed in mW per square cm of exactly the same intensity ii Know the I R energy 1mW for the duration of 1s corresponds to 1mJ in absolute terms No 37360 Ordering Information 37360 TAIL FLICK UNIT complete with following standard accessories 37215 303 Pedal Switch complete with cable 37360 302 Instruction Manual on USB key 52050 09 CUB Software on USB key 52010 323 USB cable E WPO008 Mains Cord Accessories and Optionals 57145 MiniPrinter 37300 Heat Flux I R Radiometer E HR 002 Replacement Bulb 37360 325 Mouse Holder 25mm diam 37360 330 Mouse Holder 30mm diam Basic Specifications I R Intensity adjustable in the interval 01 99 in one digit steps Reaction Time three digits 0 1s steps Calibration via appropriate I R Radiometer Universal Mains 85 264 VAC 50 60Hz 20 W max Physical Dimensions 43x22x10cm Weight 4 0 Kg Packing 65x
86. d with the standard package Data Acquisition The 37215 incorporates an optical switch to enable the connection to the optional Multifunction Printer Cat 2600 via the dedicated cable 2610 D The Multifunction Printer is a microprocessor controlled device designed to acquire data from 6 independent channels each Analgesy Meter requires 1 channel The data stored in the 2600 internal memory and shown on its graphic display can be printed out in real time and or routed to the PC via the 52050 CUB Softwa re Package included with the 2600 Ask for details Specifications Power Requirements 115 or 230V 50 60Hz 15W max Start Stop by pedal switch Force Range 37215 Oto 250 500 750 grams 37216 Oto 125 250 375 grams Physical Dimensions cm 40 x 16 x 14 Packing gt om55x45 x 36 Weight gt 2 1Kg Shipping Weight 5 0Kg approx Ordering Information 37215 ANALGESY METER complete with following standard accessories 37215 302 Instruction Manual on USB key 37215 303 Pedal Switch complete with cable 37215 323 Set of discs for additional weight 37215 321 Plinth 37215 322 Standard Pusher E WP008 3 Mains Cord The pusher can be ordered in special material and or shapes according to customer s requirements 37216 ANALGESY METER low pressure mo del suitable for mice complete with chisel shaped pusher 37215 326 Bibliography METHOD PAPER L O Randall and J J Selitto A Method f
87. e help button will display the Launcher user manual online Activation Keys the software activation keys can be ente red via a virtual keyboard Additional sof tware activation keys may be purchased separately Remote Service remote service is possible thanks to a specific software installed on the Touch Screen Controller UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 Ordering Information 40500 001 Touch Screen Controller amp Shocker Available Software and Activation Keys 40530 010 Activation of Active Avoidance Software 40550 010 Activation of Passive Avoidance step through Software 40570 010 Activation of Passive Avoidance step down Software 46100 010 Activation of Fear Conditioning Software See also the following datasheets 40530 Passive Avoidance step through 40550 Passive Avoidance step through 40570 Passive Avoidance step down 46000 Fear Conditioning System Specifications Inputs 4 Input voltage TTL input 0 5Vdc opto isolated LCD 12 with resistive touch screen CPU Module Port 2 USB Port 2 0 1 Ethernet port 10 100Mb 1 DVI port for external monitor 4 output for Sound Shock and light Power supply 12V 2A Peripheral Port Expansion Bus Connection 2 RJ11 connectors USB port type B only for software connection Physical Weight 2 7Kg Shipping Weight AKg Dimensions 25 d x 33 w x 5 5 h cm Packing 53x41x13cm 52 0205 ugo
88. e Data Acquisition available as optional ivi ACTIVITY for Rodent Activity 2600 Multifunction Printer Cat No 1800 1850 General The Activity Wheels are designed to provide an easy and convenient method for measuring motor activity over long periods of time in laboratory rodents Especially useful for research on circadian rhythms or motor function when connected to the 2600 Multifunction Printer or to any other data acquisition systems Main Features Flexibility version for rats or mice All stainless steel wheel construction Easy monitoring compatible with Clear polycarbonate cage for total visibility any Data Acquisition System Ugo Basile more than 10 000 citations ROTATING WHEELS FOR RODENT ACTIVITY 1850 Mouse Cage The 11850 is the classic 25 cm diameter running wheel made of stainless steel provided with low friction Te flon bushing for quite smooth action The mouse runs on 2mm bars placed 7 mm apart The wheel is housed in a clear polycarbonate cage A Stainless steel wire lid with exclusive lid locks incorpo rates a 500 ml water bottle and a U shaped food hopper for pellets The Mouse cage is dimensioned 37 h x26 w x358d cm 1800 Rat Cage The Rat Cage is similar to the mouse model the run ning wheel has 35 cm diameter The 2 mm bars are pla ced 8 8 mm apart Dimensions of the Rat Cage are 48 h x32 w x47 d cm Revolution Counter Each cage is com
89. e can manage up to 5 animal cages for either rat or mouse one shocker is required for each cage The friendly to user software provided as standard manages the system and experi Specific Models Vogel Conflict Test mental configuration collects and saves the Lickometer experimental data and provides a detailed for Rat report Anxiety Testing Data are saved as csv file and rpt file a proprietary 3 for Mouse Multiple Chambers format which can be opened only within the Licko meter software Main Features Upto 5 animal chambers with grid floor lick sensor water reservoir Software for experiment configuration and data collection Two pole shockers with adjustable shock intensity Chambers can be used as a general lickometer Ugo Basile more than 10 000 citations LICKOMETER VOGEL TEST Rationale of the Test The Drinking Conflict Vogel test usually consists of three pha ses Initial wait triggered by the first licking event Shock phase the sipper is electrified No shock phase no shock is associated to drinking For each phase of the experiment the number and the timing of licking events is recorded and graphically displayed The alternation between shock and no shock phases can be based on TIME or N OF LICKS according to the user experi mental paradigm When no shock is delivered the system can be simply used as a software driven l
90. e connected to the same Controller If more than one cage is connected an expansion box 40500 005 is required for each additional cage Passive Avoidance Cage step down The cage dimensioned 28 w x23 d x26 h cm is provided with a top lid the cage floor is made of 0 2cm diam bars spaced 0 5cm apart wired to the constant current 8 pole scrambling circuit located in the control unit The deta chable circu lar platform diam 7cm is positioned at the centre of the cage on a protruding stud fastened to the actua tor the me chanism which energizes the platform vibra tion A larger platform diam 11cm is also supplied with the standard package No 40570 Principle of Operation When the elevated platform onto which the animal is dropped becomes uncomfortable because of vibrations the animal steps down to an electrified grid When the mouse confronts the electrified grid and re turns to the platform the stop command or pedal switch is used to halt platform vibration and stop the latency counter the touch screen controller records the latency time in tenths of seconds The latency figure remains frozen until a new session is started experimental data are stored inside the control ler memory for further processing The vibration intensity is selected from 10 to 100HZz in 10 steps 10Hz each The shock intensity can be preset in the range 0 to 3mA in steps of 0 1MA A delay up to 15 se
91. e hierarchies Cat No 46503 General The new Ugo Basile Sociability Apparatus 3 chambered social test is a valuable tool to study SOCIAL INTERACTION in mice It consists of a transparent Perspex cage a special non reflective grey colored floor and 2 grid enclosures Many authors e g Moy et al 2004 Nadler et al 2004 have shown that a 3 chambered box can be used to test Social Novelty Preference Sociability Dominance Main Features Works even with the most basic video tracking software Grid Enclosures maximize animals interaction Different colours and sizes are available on request Ugo Basile more than 10 000 citations SOCIABILITY APPARATUS 3 CHAMBERED SOCIAL TEST Rationale and Outline of the Procedure The Ugo Basile 3 Chambered Apparatus can be used with many different procedures In their 2004 paper Moy and co authors see biblio graphy describe a typical procedure after a period of habituation a mouse sociability is determined by me asuring the time spent by the freely moving mouse in the proximity of the grid enclosures containing the first stranger mouse A second stranger mouse is then introduced in the box and the preference for the new stranger mouse can be easily assessed 3 Chamber Box amp Grid Enclosures The clear Perspex box gives ideal transparency for vi sual observation of the experiment or for side positio ning of the v
92. e materials were selected to be sturdy and easy to clean to construct reliable and durable mazes Main Features High contrast non reflective colors optimized for Video Tracking Quality materials light easy to clean and to store Surface texture selected for best rodent s comfort reasonable rough warm surface Ugo Basile more than 10 000 citations ANIMAL MAZES Water Maze Pool The Ugo Basile Water Mazes are water pools specifically manufactured for Morris Water Maze experiments i e not a cattle drinking trough and include wheels and drain hose built in connec tors for Hydraulic Atlantis Platforms not included customizable co lors and dimension on request animal platform fixed height 10 or 12 cm diameter Pools are 60 cm high and 120 150 or 180 cm diameter Barnes Maze Mouse version 100 cm diameter 5 cm hole diameter Rat version 130 cm diameter 10 cm hole diameter Both versions are 60 cm high and are painted in non re flective grey or light blue white black or other custom colors are available on request The animal shelter is included and is magnetically attached to the maze for quick and easy experiments Elevated Plus Maze and Zero Maze Zero Maze Elevated Plus Maze These mazes are manufactured from high tech metal alloy and can be painted in different colors Dimension cm Elevated Plus Maze Mouse arm lenght 35 arm width 5
93. eat value to quantify at presettable intervals the solid amp liquid intake in investigations about the drugs which produce anorexia the addiction aversion to particular substances the thirst arousing and quenching the feeding habits and its modification brought mechanism about by environmental conditions Ugo Basile more than 10 000 citations FEEDING amp ACTIVITY ANALYSER No 47552 47553 47555 Animal Cage Two types of cages are available 47552 designed for Rats and 47453 for Mice Both cages have transparent walls and lid to allow the animal observation The cages which are provided with a catch pan can be easily detached from its Base structure for cleaning or servicing They incorporate load cells which sense the load of food and liquid thus recording their ingestion with 0 1 g accuracy and monitoring the frequency of food liquid uptake The trough shaped as an open box is made of smooth gnaw proof plastics It glides into a receptacle made of stainless steel fastened to its scale pan The crumbs the animal produces are collected in the front compart ment for a precise evaluation of the food consumption The water bottles are provided with a spout and rest on a support stud fastened to the scale pan for monito ring quantity and frequency of water uptake Provision is made to collect any dripping for a more precise water consumption evaluation The inside dimensions of the rat cage are
94. ectenaeacialenmeentaateatannnaewesienaet 21000 Gas Anaesthesia Systems oo ccccccccccccesessccceecesseceecescessneceecessesseeeeecenseeeecesesaeeeeseeseees 7900 10 Anaesthetizing Boxes and Gas Anaesthesia Accessories cccecccccceceeeseeeeeeeeeeees Ugo Basile more than 10 000 citations your trusted partner ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS roadmapping the future of behavioral research BEHAVIOUR CONDITIONING REWARD 40500 001 Touch Screen Controller oo cccccceseseseeeeee ens NEW FUNCTIONS 51 46000 Fear Conditioning Systems ccccccccccccceeeeceeeceeeeeees NEW SOFTWARE 53 40532 Active Avoidance Set Up Shuttle Cage for Rats NEW MODEL 55 40533 Active Avoidance Set Up Shuttle Cage for Mice NEW MODEL 55 40552 Passive Avoidance Step through for Rats NEW MODEL 57 8 40553 Passive Avoidance Step through for Mice NEW MODEL 57 40570 Passive Avoidance Step down for Mice 6 NEW MODEL 59 47502 Learned Helplessness for Rats ccccccceceesereeeeeeees NEW MODEL 61 47503 Learned Helplessness for Mice sscssscccescrsserer NEW MODEL 61 42552 Conditioned Place Preference CPP for Rats ccccccccccccceecscsecceeseeseceecsecseeeeeese
95. ed UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 22 01 2014 j ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com Durham Animal Holders OrofacialPainassessment Trigeminal New animal holders for trigeminal stimulation Mechanical and Thermal hyperalgesia Nociception Cat No 37100 General The Durham Animal Holders are the newest accessory for use with the Plantar Test Hargreaves Test and Dynamic Plantar Aesthesiometer manufactured by Ugo Basile These animal holders complete the scope of the infrared IR thermal stimulus of the Plantar Test or the mechanical stimulus of the Dynamic Plantar Aesthesiometer used for assessing hind paw withdrawal This new invention allows the application of the same stimulus to the region innervated by the trigeminal nerve The 37100 includes two holders form molded for testing specific size ranges of animals the two sizes have been optimized for yourg adult rats as well as for bigger rats Very nicely done easy to use and it greatly facilitates consistent handling of animals Dr Ken Hargreaves UT Texas Main Features Correlation thresholds in submandibular trigeminal region and hindpaw plantar surface Test orofacial nociception using a standard Plantar Test Hargreaves device a Dynamic Plan tar Aesthesiometer or an eVF Electronic Von Frey 23 Innovative design and material The D
96. ed Plus Maze Mouse Open Field 44cm Elevated Zero Maze ANXIETY DEPRESSION FEAR STRESS Lesion Making Device Stoelting Stereotaxic Instrument KDS Infusion Pumps NEW DataCapsule Evo Digital Recorder ELECTROLYTIC LESIONS AND INFUSION Rotometer ECT Unit EPILEPSY SEIZURES CONVULSIONS BRAIN CHEMISTRY Microwave Brain Fixation NEW 5KW PHOSPHORYLATION be ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com Plethysmometer Cat No 37140 General In research on rheumatoid arthritis the central development of oedema and its modifications by pharmacological processes it has proved of great value to measure inflammatory processes in the rat paw Our Plethysmometer 37140 displays the exact paw volume on the graphic LCD read out Small diffe rences are detected by a transducer of original de sign The 37140 is provided with a pedal holding com mand which freezes the reading enabling the ope rator to concentrate its attention to the paw dip ping The paw volume is shown on the multifunction gra phic display in four digits with 0 01 ml resolution A l q zero key is provided to zero the meter before each Now supplied with FOR ACCURATE k EA A AEE measuring cell for MEASUREMENT OF k d both RAT amp MOUSE RAT paw oedema paw MOUSE paw oedema MICROPROCESSOR Controlled Instrument Main Features Computer compatibility direct connection
97. eight 1 0 Kg Packing 39x27x21cm Bibliography F G Garrett et alia Validation of a Novel Rat Holding Device for studying heat and mechanical Evoked Trigemi nal Nocifensive Behavioral Responses J Orofacial Pain 26 No 4 336 344 2012 F G Garrett A E Overmyer L A Vause J L Hawkins J B Hayden and P L Durham Development of a novel device for measuring withdrawal latency by thermal stimulation in rodent facial pain models using the Hargreaves Plantar Apparatus Poster presented at SFN 2010 ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com Grip Strength Meter Cat No 47200 General The Ugo Basile Grip Strength Meter automa tically measures grip strength 4e peak force and time resistance of forelimb or hindlimb via the optional grid in rats and mice The Grip Strength test is a perfect complement to the gold standard Ugo Basile Rota Rod de vice for motor coordination and motor fun ction experiments The effects of drugs toxins muscle relaxants disease ageing or neural damage on muscle strength may be assessed The animal is placed over a base plate in front of a grasping tool either T shaped trapeze shaped or grid whose height is adjustable The bar is fitted to a force sensor connected to the control unit which can be used as a stand alone or connected to a PC via the USB port for monitoring and data recording via the NEW software p
98. elerating models They basically consist of four 6cm diam drums suitably ma chined to provide grip Five flanges divide the four 8 7cm lanes enabling four rats to be on the treadmill simultaneously When a rat falls off its cylinder section on to the plate below the plate trips thereby recording the animal s en durance time in seconds Height to fall is 30cm A large very readable backlit graphic display shows the actual angular speed RPM At the end of a run the di splay shows for each animal the running time and the in strument rotation speed at the time that animal fell off The panel can be oriented to select the most comforta ble angle for the operator to avoid glare etc The main features digitally preset by function keys are the following the angular speed can be preset in the range 2 80 RPM revolutions per minute in the acceleration mode the change of speed can be preset in 6 second 10 minute interval in 6 second steps reverse rotation can be selected which takes pla ce at minimum speed at the end of a pro grammable acceleration deceleration sequence arocking motion is also presettable with adjusta ble angular amplitude speed and acceleration Data Acquisition The 47700 is microprocessor controlled and features di rect PC output Internally stored data can be routed to the PC serial port RS232 or USB via adaptor provided Data output is managed by 52050 07 Data Acqui
99. emely simple Multiple Cage Set up up to 16 cages in groups of 4 53 Screen Controller 40500 001 just purchase the hardware System Components Software and IR CCD camera The Ugo Basile Fear Conditio ning system benefits of a spe cific version of the Any maze software Cat No 60000 FC the software controls the Ugo Basile hardware automatical ly detects the freezing beha vior and analyzes the results across time Measured parameters include Total Freezing time No and duration of freezing episodes across time The USB videocamera 47400 030 is sensitive to IR light and allows for freezing detection even in total darkness Wide angle lenses and IR filters are included Controller The new FC Controller 46000 100 consolidates all con trols in a single compact electronic unit On its 12 touch screen the researcher sets the fol lowing parameters via the user friendly interface Sound in the range 100Hz 40KHz 1 150dB or white noise The speaker is included in the Cubicle Shock constant current from 0 1 to 2 9 mA in 0 1 mA steps The shock can be controlled via external operation via 5V TTL signals Light Connections are arranged on the controller back panel Animal Box with Electrified Grid Floor 46003 Mouse Box inside dimensions 17x17x25 h cm 46002 Rat Box inside dimensions 26x26x30 h cm Context Kit A complete set of removable contexts is pro
100. er the range from 0 to 50 g see table on the facing page The high sensitivity 7010 is designed for the mg range The force exerted on a hollow carbon fibre beam is converted into proportional electric signal via Strain gauges conveniently wired in Wheatstone bridge circuit Model Selection Ugo Basile transducers are of robust construction and can withstand forces of up to 5 10 times the rated value It is possible to use 7003 which is generally used for trachea rings or artery strips where forces of 5 10 grams are involved by operating at minimum am plifier sensitivity however the cantilever will de flect with a load of the mentioned magnitude Generally speaking it is advisable to use a stiff 3 transducer operating at high amplifier sensitivity and use the most sensitive transducer only when Main Features The picture shows an Isometric TrAnsducer right amp an Isotonic Transducer left see separate datasheet Also available from Ugo Basile Tissue Baths 1 2 4 chambers Digital Recorder DataCapsule Evo Electrodes amp Stimulators Ugo Basile transducers have been designed for precise measurement of force in muscular preparations under isometric conditions An Isometric Transducer measures changes in force at constant length whereas an Isotonic Transducer is basically a displacement meter under constant load 83 ISOMETRIC TRANSDUCER lsometric Transducer Specifications m
101. esolutions Sample Speed Input Range Excitation Voltage Input Impedance Trigger Mode System Noise Analog Output Analog Outputs Output Resolution Output Range Stimulator Modes Time Step Pulse Width max Frequency Physical Power Requirements 22 w x26 d x5 h cm Net Shipping Weight Instrument Size No 17304 4 independent amplified chan nels 24 bits differential 1 2 5 10 20 50 100 200 500 1K 2K 5K samples second 10V 5 VDC 50mA per channel 667 GigQ tup 182 GigQ Min external trigger TTL or Con tact Closure Threshold Trigger from Data User Trigger 32 microvolts 4 16 bits 10VDC Pulse Train Constant Step Ramp Triangle 0 04ms 0 4ms 4ms 1 25 12s 120s 12 5KHz 1 25KHz 125KHZz 115 230V 50 60Hz 22W max 2 0Kg 4 0Kg Ordering Information 17304 DataCapsule Evo 4 Channel Digital Recorder standard package including LabScribe2 Software Transducers The DataCapsule can be connected to a variety of transducers Among the ones offered by Ugo Basile 7003 F Isometric Force Transducer type DY1 7004 F Isometric Force Transducer type DY2 7005 F Isometric Force Transducer type DY3 7010 F High Sensitivity Transducer type DYO 7006 F Isotonic Transducer 17844 F Pressure Transducer 88 Le a i TRANSFORMING IDEAS o basile A INCTD O INS www ugobasile com ECT Unit
102. etized guinea pig breathing via a reciproca ting pump according to Starling s mode of operation See sketch below CLAMP E TO RECORDER Sensitivity The sensitivity of the instrument in comparison with conventional Konzett Roessler apparatus as illustrated in the table below Minimum dosage in ug Kg giving significant readings K R Apparatus UGO BASILE 7020 Histamine 3 6 0 3 0 6 Acetylcholine 20 40 3 10 Serotonin 6 15 1 3 Air Flow Meter The recording system monitors respiratory dynamics by providing a tracing appearing as a succession of spikes When bronchospasm occurs overpressure displaces the water column inside the T tube and air bubbles through the water escaping through an air flow tran ducer which are generating an electrical signal When Bronchodilators are administered overpressure is reduced to below normal breathing values as the bronchi exert less aerodynamic resistance to forced in Spiration The tracing will decrease in amplitude to a marked de gree enabling the action of bronchodilators to be asses sed Ordering Information 7020 Bronchospasm Transducer complete with following parts 7021 Air Flow Head 7022 Set of two Steel Rods 7024 Side Reservoir 7015 Instruction Manual on CD Ask for details about 7025 Rodent Ventilator Physical Weight 2 7Kg Shipping Weight 5 2Kg Packing 40x39x30cm Bibliography Method Paper H Konzett amp R Roessler Arch E
103. ew model for rats amp mice complete with following Standard accessories 47200 001 Control Unit with Power Supply 47200 002 Force Sensor 47200 004 Baseplate and upright 38500 011 DCA Software on USB Key M LM 589 T shaped Grip Bar M LM 590 Grip Trapeze for Rat M LM 588 Grip Trapeze for Mouse 38500 303 Pedal Switch 52010 325 USB Cable All components lodged in a dedicated plastic case Optional 47200 325 Mouse Grasping Grid 47200 326 Mouse Grasping Grid blind top Physical Weight 4 8kg Shipping weight 6 5Kg Packing 46x38x27cm Bibliography GJ Huang et alia Ectopic Cerebellar Cell Migration Cau ses Maldevel opment of Purkinje Cells and Abnormal Motor Behaviour in Cxcr4 Null Mice PLoS ONE 9 2 e86471 2014 Mouse R Barone et alia Endurance Exercise and Conjuga ted Linoleic Acid CLA Supplementation Up Regulate CYP17A1 and Stimulate Testostero ne Biosynthesis PLoS ONE 8 11 e79686 2013 Mouse N Lange et alia Behavioural and Pharmacological Exa minations in a Transgenic Mouse Model of 2 early onset torsion dystonia Pharmacology Biochemistry and Beha vior 97 4 647 655 2011 Mouse M Savic et alia Behavioural Characterization of Four En demic Stachys Taxa Phytother Res 2010 Rat A Coluccia et alia Developmental Omega 3 Supple mentation Improves Motor Skills in Juvenile Adult Rats Int J Devl Neuroscience 27 599 605 2009 Rat
104. f a drug on the animal s activity Psychopharmacology screening drugs which are potentially active on the CNS Behavioural Sciences in evaluating the variations of spontaneous activity after changes in environmental conditions Ugo Basile more than 10 000 citations Activity Cage Instrument Description The 47420 MULTIPLE ACTIVITY CAGE package com prises an Electronic Unit Cat 7441 an I R Beam Cage This set up can accept up to 5 additional cages for a total of 6 Electronic Unit The 7441 designed to process the data originated by up to 6 Cages incorporates a graphic display a thermal printer and a serial port RS232 for direct connection to the PC via the software Cat 52050 included A serial to USB adaptor is also included The graphic display presents all available commands The operator sets the experiment configuration via the keyboard located below the display The activity data are displayed at preset intervals and printed routed to the computer according to the selec ted configuration The data can be customized by ad ding animal amp experiment numbers gender etc Its internal memory is capable to store the data of seve ral experiments to be unloaded to the PC later Cage The 7433 Cage consists of a cubicle entirely made of clear Perspex dimensioned 41x41x33 h cm Upper lid and bottom catch pan detachable for cleaning The cubicle rests on a sturdy base provided with four
105. ganglia Neuropharmacology 39 1637 1644 2000 A Nishi et al Amplification of dopaminergic signaling by a positive feedback loop PNAS Early Edition 1 6 2000 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 03 2013 108 For the past 5 decades we have provided scientists with the unmatched tools necessary to transform their ideas into meaningful research and results We look forward to working with you and to another 50 years t revision
106. gh contrast colors and non reflective coatings providing optimal results with any video tra cking software Ugo Basile mazes are con structed of sturdy and easy to clean materials making them the most reliable ma zes on the market Surface texture was selected for best rodent s comfort The proprietary doors sli ding underneath the floor make it the best solution for videotracking and optoge netics test Main Features New proprietary modular system Manual or PC driven operation modes via TTL or Easily cleanable Smooth and silent operation USB connection Doors slide underneath the floor Interchangeable walls for egocentric or allocentric spatial memory tests different colors or textures available on request Ugo Basile more than 10 000 citations MULTI MAZE SYSTEM for Mouse System Description The new MOUSE MULTI MAZE Cat No 41500 is a modular sy stem enabling the user to set up an electronically controlled maze by combining one of the different arenas provided and the required number of arms in the following configurations Mouse Y Maze Mouse T Maze Mouse 8 Arm Radial Maze This feature is facilitated by the new concept introduced with this recent version the door controlling kinematics of each sec tion is actually integral part of the arm itself being positioned below the door area while a control unit positioned below the central arena consolidates the motor co
107. go Basile New Gas Anesthesia is a compact modular and reasonably priced system intended to match the highest technical requirements of ani mal labs that do not compromise on quality A wide range of options and accessories are avai lable most of which can be added in a scalable manner making the system modular and with an excellent value for price Typical anesthesia procedures involve an induction phase and a maintenance phase which require at least Flow meter and anesthetic Vaporizer Induction box and or mask with breathing cir cuit Scavenger or flow hood for gas anesthetic re _ Portable THEIDEAL MATCH The Ugo Basile New Gas Anesthesia system include all of the above and much more 3 TO UGO BASILE LINE Modular _ oF VENTILATORS Main Features Digital Flowmeter with wide range up to 16 litres per minute for multiple animal delivery Up to six Animals with one Station Manifold for mask induction box switch and full range of accessories NEW Tec3 Vaporizers non refurbished Ugo Basile more than 10 000 citations GAS ANESTHESIA SYSTEM Overview The unique digital flowmeter coupled to non refurbi shed vaporizers for Isoflurane or Sevoflurane result in an innovative yet sturdy and reliable system to anes thetize animals of virtually any size and up to 6 animals simultaneously An ample selection of modular components and acces sories enables the user
108. gy University of Cagliary Italy for the initial design of the boxes her valuable comments and suggestions allowed us to keep the focus on the user needs and opinions L Fattore et alia Baclofen Prevents Drug Induced Rein statement of Extinguished Nicotine Seeking Behaviour and Nicotine Place Preference in Rodents Eur European Neuropsychopharmacol in press 2009 M Scherma et alia Inhibition of Anandamide Hydroly sis by Cyclohexyl Carbamic Acid 3 Carbamoyl 3 yl Ester URB597 Reverses Abuse Related Behavioral and Neuro chemical Effects of Nicotine in Rats J Pharmacol and Ex per Therap 327 482 490 2008 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 03 2013 64 UD g BEHAVIOUR CONDITIONING REWARD TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com Lickometer Vogel Test Cat No 45100 Set up for Rat Cat No 45150 Set up for Mouse General The Ugo Basile Lickometer Vogel Test is a versatile system that can function as a simple software based lickometer or as a Drinking Conflict set up to assess the anxiolytic effect of drugs In the Drinking Conflict Vogel paradigm a wa ter deprived animal is exposed to a lickometer and the licking events are coupled to electric shocks The animal is in a motivationally conflicting si tuation hence his licking behavior is affected by anxiety and anxiolytic drugs The Lickometer controller and softwar
109. harmacology 66 253 263 2013 J Marrocco et alia Anxiety Like Behavior of Prenatally Stressed Rats Is Associated with a Selective Reduction of Glutamate Release in the Ventral Hippocampus J neuroscience 32 48 17143 17154 2012 C Romei et alia The GABAB receptor antagonists CGP35348 and CGP52432 inhibit glycine exocytosis Study with GABAB1 and GABAB2 deficient mice Phar macological Res 61 547 552 2010 M Grilli et alia Specific Inhibitory Effect of Amyloid B on Presynaptic Muscarinic Receptor Subtypes Modula ting Neurotransmitter Release in the Rat Nucleus Accum bens Neuroscience 167 482 489 2010 G Bonanno et alia Release of 3H D aspartate induced by K stimulation is increased in the cervical spinal cord of the wobbler mouse a model of motor neuron disease Neurochemistry Intl 55 302 306 2009 M Grilli et alia Release enhancing pre synaptic mu scarinic and nicotinic receptors co exist and interact on dopaminergic nerve endings of rat nucleus accum bens J Neurochemistry 105 6 2205 2213 2008 In addition more than 300 full papers using superfused sy naptosomes have been published UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 03 2013 82 j ugo basile i E ail Y E TRANSFORMING www ugobasile com isometric Transducers Cat No 7003 7004 7005 amp 7010 General The three models 7003 7004 7005 cov
110. his test was performed on animal 3 whose treatment a KZA 10 moto The test was tral Testing completed numee Stet ofsa Pause sOn Off Rests You cen use he Results reports shown here Test duraton Total stance reveled Overal average speed and date secton of he Protocol page to select the ressis s26s 13 1616 0250 avs Take a tour and see for yourself The quickest way to learn more about ANY maze is to take a brief introductory tour Download ANY maze and try it out Why not try ANY maze for yourself you can download the complete system for free We ve even included some experiment videos so you can see the tracking in action Video tracking your animals in a wide range of behavioural apparatus Morris Water Mazes Elevated Plus Mazes O T Y Mazes Radial Mazes Open Fields Home Cages Metabolic Cages Place Preference Boxes Porsolt Forced Swim Tests Tail Suspension Tests Ugo Basile more than 10 000 citations Any maze Equipment ANY maze s flexible design makes it easy to set up ex periments in a wide range of different apparatus plus maze water maze T maze activity boxes forced swim test open field cages Fear Conditioning etc Our extensive range of high quality mazes amp test appa ratus have been designed in cooperation with experien ced behavioural scientists and are optimized for video tracking include What s more all our mazes and test apparatus
111. ickometer The duration of each phase is user defined for each cage ba sed either on time or on the animal behaviour i e the sipper is electrified after a defined number of licking events have oc curred At the end of the test a report will summarize the results these results can be automatically printed and exported into a spre adsheet System Components The system is composed of USB Control Unit for up to 5 cages including Software Drinking Conflict Cage 2 Pole Sine Wave Shocker Animal Cages Drinking conflict cages are provided with grid floor elec trified sipper and lick sensor Two sizes are available for rats and mice The rat cage inside dimensions are 35 w x25 d x30 h cm The mouse cage is dimensio ned 20 w x24 d x20 h cm Lickometer Software The following parameters which define the experimental con figuration can be set via the software for each cage Trial duration Initial Pause Time Intervals with and without shock Number of licks to deliver a shock etc No 45100 45150 wf wm z re s l l oe Q SHOCKER FOR DRINKING CONFLICT TEST ene we rare DEN ae A boem mery low roy gt gt haad Experiment configuration For each cage it is possible to assign a specific name to report operator and animals involved in the experiment sex and weight of the animals can also be specified Cage configur
112. ideo camera Dimensions for each of the 3 compartments are 20x40x22 h cm two sliding doors 5x8 h cm opening on the central compartment can be closed to confine the animal The grey floor gives high contrast with both light and dark animals allowing for automated video tracking of the animals Its special painting also gives a slightly rou gh surface pleasant for the animals to walk on The grid enclosures allow mice to interact closely the grid bars have a diameter of 3mm and are spaced 7mm The standard enclosures are 15cm tall and have an internal diameter of 7cm The top and the bottom are made of grey 46503 003 or white 46503 013 PVC Different sizes colors areavailable on request No 46503 Optimized for Video Tracking The grey floor gives best contrast to both light and dark animals which is the most critical factor for all video tracking softwares to work properly Images and videos courtesy of Dr Patrizia D Adamo San Raf faele Institute Milan Italy Ordering Information 46503 Mouse Cage for Sociability complete with following components 46503 003 Grid Enclosure for Sociability stranger cage grey D 7cm 15cm h 2 pieces 46503 010 3 Chambered Transparent Cage with two doors M LM 570 Metal Floor special non reflective color 46513 Mouse Cage for Sociability complete with following components 46503 013 Grid Enclosure for Sociability stranger cage wh
113. ideotracking for Rats Mice eee aia G 41500 Modular Multi Maze System for Mice Y T Radial a NEW 75 TISSUE BATHS TRANSDUCERS STIMULATORS 4000 Isolated Organ Baths single chamber 2 chambers 4 chambers oa 77 3165 Multiplexing Pulse Booster sssssssssssssssssesssrisesssssseressrsssressresssrsrirsressresrrsseresereserns 79 Ugo Basile more than 10 000 citations your trusted partner ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS roadmapping the future of behavioral research 14900 S perrusion Syste sescesectece cus srnectsntetesecut ener E E EEEE EIEE EERE ENS 81 8 7003 Isometric Force Transducers DY1 sssssssssesssrssessserrersrsrrrstoreresssrseressreserrsrrrerrrerens 83 7004 Isometric Force Transducers DY2 usssssusssessrssesssrrrstrestresroreresesrseresrressrirrrrsrrrerens 83 7005 Isometric Force Transducers DY3 ct tusevascussnecosataceseacan cadet etesense venalntaetdesorveteasioneneteas 83 7010 Isometric Force Transducers DY Ose cassecscceeasteansncencacsscsencectecer ncsrnanacstoncauenbiaasniscnaens 83 7006 Isotonic Transducer xe csanet cs seaicsn dictareitenetoatcoan sani nshesertancets olen vodantanyeeictancaun tinea Rubeaetenceemeatine 85 17308 DataCapsule Evo Digital Recorder scssi NEW MODEL 87 MISCELLANEOUS ECT LESION MAKING DEVICE 53500 Lesion Making Device ssusssssssesesserssssrerseseseereserosserreesssersssoerresesesrereseeresereseess
114. ied Special electrodes can be designed and manufac tured on request Please ask for details Connection to Digital Recorder A one channel stimulator can be conveniently repla ced by a data acquisition system as for example our 17304 DataCapsule Evo No 3165 Ordering Information 3165 MULTIPLEXING PULSE BOOSTER complete 3165 302 Instruction Manual E PE015 Connection Cable E WP 008 Power Cord Optional 3175 Timer for 3165 PHYSICAL Power Requirement 115 230 V 50 60 Hz 30W Dimensions 26 w x30 d x12 h Weight 4 4Kg Shipping Weight 6 5Kg approx Packing 46x38x27cm Bibliography D Curro Voltage gated calcium channels invol ved in the inhibitory motor responses and vaso active intestinal polypeptide release in the rat gastric fundus Eur J Pharmacol 628 207 213 2010 F Guagnini et alia Tolerance to cannabinoid response on the myenteric plexus of guinea pig ileum and human small intestinal strips Br J Pharmacol 148 1165 1173 2006 F Borrelli et alia Effect of Boswellia serrata on intestinal motility in rodents inhibition of diar rhoea without constipation B J Pharmacol 148 553 560 2006 M G Matera et alia Immune Sensitization of Equine Bronchus Glutathione IL 18 Expres sion and Tissue Responsiveness Respir Res 6 1 104 2005 S Tambaro et alia Evaluation of Tamsulosin and Alfuzosin Activity in the Rat Vas Deferens Rele vance to Ejaculatio
115. igh resolution and sensitivity over conventional recorders This versatile digital recorder is a unique system in that each channel is independent each having its own analog to digital converter In addition each channel input is equipped with the appropriate filters and amplification required Set up is plug and play easy with connection to PC or MAC computers via USB interface data acquisi tion is accomplished via the versatile LabScribe Sof tware provided with the system Main Features USB connection to PC and MAC Connectors for most transducers DIN inputs and BNC outputs LabScribe2 4 CHANNEL DATA Software on board _ ACQUISITION SYSTEM Each channel is 5KHz Sampling Speed independent Input trigger to start recording High resolution and sensitivity Each channel equipped with programmable stimulator 87 DATACAPSULE Connections and Specifications All four channels have two connectors an 8 pin DIN in put and a BNC output Cable adaptors allow connec tion of a variety of sensors and transducers Each channel is independent having its own 24 bit ana log to digital converter The maximum sampling speed is 5KHz on all channels simultaneously Analog Outputs Each channel of the 17304 is equipped with an inde pendently programmable 16bit 10V stimulator All stimulus parameters may be controlled via the LabScri be Software from the stimulator tool bar Eight d
116. igital outputs are available to control external devices programming the output lines is point and click easy Resolution and Noise The 17304 features high resolution combined with an exceptionally low noise as low as 32 uV Software and Data Management The DataCapsule Fvo setup is plug and play easy with connection to PC or MAC computers via the popular USB interface Recorded data are managed by the versatile LabScribe2 Software featuring optimized scaling of displayed data time base or y axis scaling can also be zoomed in or out with a single click of the mouse Keyboard input from the user may be time locked to the data annotations may be positioned in the data just as you would write on chart paper Twenty four off line calculations are also supported in cluding Max Min Slope at a Point and Mean Any view of the data can be exported to the disk as a text file or graphic This capability is ideal for post calcu lation in programs like Exce or MatLab Of course data from any window in the program can always be printed DataCapsule Evo Specifications LabScribe2 onboard Display Real time user definable Scre en Time independent of Sam ple Rate user Definable Units AugoScale Full Scale or User Defined Scale Power Requirements 115 230V 50 60 Hz 22W max Software UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 Analog Input Analog Inputs Input R
117. ilibrating Coil 4100 Muscle Chamber 10ml provided This is similar to the one chamber bath 4000 but the with porous frit and hook tank is dimensioned 34x19x17cm to accomodate two muscle chambers and syringe valves two coils two ad 14110 Lead Screw Positioner for 10 amp 13mm rods justable support rods and holders for transducers l 4004 Supporting Rod 10mm diam 4000 302 Instruction Manual Bath 4400 E WP 008 Mains Cord The bath 4400 lodges up to 4 preparations they main tain the features of the 4050 but heating power and 4050 Isolated Organ Bath 2 Muscle Chambers dimensions are upgraded accordingly the tank being as above but all standard accessories multi 47x29x22cm plied by two i e 2x4005 2x4100 etc 4400 Isolated Organ Bath 4 Muscle Chambers Tissue Chamber Configuration as above but all standard accessories multi The tissue chambers provided with porous frit avail 3 plied by four i e 4x4005 4x4100 etc able in 5 10 20 30 or 50 ml are standard unless oth erwise specified we supply our tissue baths with 10ml 3 Physical muscle chambers 3 4000 Dimensions TN Weight 4Kg An accurately positioned glass hook is provided in the chamber to which the thread loop can be easily at R eot l A tached ensuring the organ being well centered in the J chamber 4050 Dimensions 47x20x22cm Weight 6 5Kg Tissue chambers are also available provided with an ae 3 Shipping
118. incenzi et alia A2A Adenosine Receptors Are Differen tially Modulated by Pharmacological Treatments in Rheu matoid Arthritis Patients and Their Stimulation Amelio rates Adjuvant Induced Arthritis in Rats PLoS ONE 8 1 e54195 2013 T Bertaim et alia Dose and Administration Schedule Ef fect of Tiludro nate on Joint Damage in the Model of Com plete Freund Adjuvant Induced Monoarthritis in Rats Open Journal of Rheumatology and Autoimmune Diseases 3 18 25 2013 E Borb ly et alia Role of Tachykinin 1 and 4 Gene Derived Neuropep tides and the Neurokinin 1 Receptor in Adju vant Induced Chronic Arthritis of the Mouse PLoS ONE 8 4 e61684 2013 R Korhonen et alia Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase 1 Br J Phar macol 169 7 1525 1536 2013 A Finlay et alia Sphingosine 1 Phosphate Mediates Hype ralgesia via a Neutrophil Dependent Mechanism PLoS ONE 8 1 e55255 2013 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 Rev 06 2013 ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com Analgesy Meter Cat No 37215 General The 37215 is the up to date version of the classi cal 7200 paw pressure test which since 1965 in a number of academic and industrial laboratories is helping to perform a rapid precise screening of analgesic drugs
119. inter 6 input channels with microprocessor for direct connection to the PC Complete with dedicated software 52050 01 serial cable amp USB adaptor 2610 F Multi Connection Cable Physical Dimensions 1800 48 h x32 w x47 d cm 1850 37 h x26 w x358d cm Weight 1800 7Kg 1850 5kg Shipping weight 1800 11Kg 1850 7Kg UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 022013 38 TRANSFORMING IDEAS INTO INSTRUMENTS ugo basile www ugobasile com Mouse Ventilator Cat No 28025 General This new Respirator which completes the well known Ugo Basile line of Ventilators features The tidal volume in the range 0 1 1 ml or 0 05 0 5 with the smaller piston installed can be selected via its knob either while the pump is running or at a standstill The stroke volume scale is ample provided with precise engra ved marks The rate selected by a knob is indicated by a 3 digit solid state display in the range 60 300 strokes per minute Suitable channels and ports provide the witching of the air flow with practically no dead space A unique variable stroke linkage mechanism operates the piston The reciprocating motion is adjusted and transmit ted to the piston by rods and articulated joints only which leads to minimal wear no backlash silent operation and exact stroke reproducibility Main Features ldeal for use with mice small birds and perinatal rats
120. ion of contextual conditioned fear in rats Behav Brain Res 207 05 111 2010 N Seferos et alia Mandibular bone density and cal cium content affected by different kind of stress in mice J Musculoskelet Neuronal Interact 10 3 231 236 2010 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 02 2015 56 EE AS INTO www ugobasile com Passive Avoidance Step Through New Model Cat No 40552 Rats Cat No 40553 Mice General Passive Avoidance Test is used to assess memory function based on the association formed between a specific environmental context which the animal learns to avoid and an aversive stimulus represen ted by a mild foot shock The tests are conducted in a two compartment ap paratus where one is dimly lit and preferable to a rodent and the other is brightly lit After the training period during the test proper the animal that learned the task will avoid the location previously paired with the aversive stimulus and show greater latency to enter it Ugo Basile Passive Avoidance set up instrument basically consists of a Controller and a Cage divi ded into two compartments by a partition which embodies a sliding door The tilting floor ensures a simple and relaible detec tion mechanism to score the animal s movement across the two compartments Main Features The electronic unit encompasses all con trols for up to 4
121. ion of Functional a Adreno metric 7003 7004 7005 7010 or Isotonic 7006 anda ceptor Subtypes in the Bovine Female Genital Tract versatile 4 channel digital recorder the 17304 Data Sse eee ru Cycle Vet es Communications 26 3 479 494 2002 Capsule Evo Ask for details Recording amp Transducers UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 78 03 2013 ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS Multiplexing Pulse Booster General The 3165 Multiplexing Pulse Booster is a useful complement to any stimulator delivering up to 800mA of constant current to up to four in vitro preparations e g smooth muscles at the same time The Multiplexing Pulse Booster has been designed to obviate the inconveniences connected to the use of single channel stimulators that lack the in dependent output connections and the individual adjustment capability to deliver pulses of preset in tensity to more than one preparation It is especially useful when field electrodes and other low impedance stimulation arrangements are used Bear in mind that the one channel stimulator can be conveniently replaced by a data acquisition sy stem as our 17304 DataCapsule Evo Main Features High Power constant current up to 800 mA Independent Isolated Circuits to eliminate interference Unipolar or Bipolar Mode Ny p i Four in vitro preparations can be driven by
122. ite I D 7cm 15cm h 2 pieces and other components as for 46503 Physical Dimensions 60x40x22 h cm Weight 9Kg Shipping Weight 12Kg Packing 67x42x53cm Bibliography M J Kane et alia Mice Genetically Depleted of Brain Serotonin Display Social Impairments Communication Deficits and Repetitive Behaviors Possible Relevance to Autism PLoS ONE 7 11 e48975 2012 M Yang et alia UNIT 8 26 Automated Three Chambered Social Approach Task for Mice Current Protocols in Neu roscience Published Online 1 July 2011 Method Papers S S Moy et alia Sociability and Preference for Social Novelty in Five Inbred Strains an Approach to Assess Autistic Like Behavior in Mice Genes Brain and Behavior 3 5 287 302 2004 J J Nadler et alia Automated Apparatus for Quantita tion of Social Approach Behaviors in Mice Genes Brain and Behavior 3 5 303 314 2004 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 02 2013 68 4 ugo basile BEHAVIOUR MAZES TRACKING G IDEAS meee e E at www ugobasile com HYDRAULIC ATLANTIS LIFTING CONTROL NO ELECTRICITY PLATFORMS NOHANDSIN for WATER MAZE experiments LOWERING CONTROL 3 THE POOL Cat No 40100 Why Automated Platforms Despite being very effective the Morris Water Maze task has some limitations related to the platforms normally used having fixed height which cannot be
123. l can be previously measured and displayed and a warning signal flashes if the impedance is too great to deliver the desired current level The special output circuit enables any type of electrode to be used The auricular electrodes 57800 002 supplied with the stan dard package allow a single operator to deliver shock to a number of animals in a short time The above picture features Corneal Electrodes Cat 57800 003 which can be provided as optional Different types of electrodes can be manufactured on request Specifications PULSE GENERATOR LL SZ ECT LOOP KOHM FREQUENCY PULSE SHOCK CURRENT WIDTH DURATION ECT UNIT 57800 Rectangular Positive Pulse by H V transformer Constant Current controlled by a feedback network Pulse Rise amp Fall Time 20us Pulse Width ms 0 1 to 0 9 in 0 1ms steps 1 Frequency pulses s 1 299 in 1 pulse s steps 1 Shock Duration 0 1 to 9 9 in 0 1s steps 1 Pulse Voltage 2 5KV max Current Range 0 99mA in 1mA steps 2 Output Resistance min OOhm max 25KOhm at max current KOhm Display 0 199 KOhm 1KOhm resolution Power Requirements 115 230V 50 60Hz 70VA No 57800 WARNING due to HIGH VOLTAGE involved the operator should always wear rubber gloves when handling the electrodes Bipolar Inverter 57800 010 An optional Biphasic Unit may be placed between the animal and the Electroconvulsive Device to invert every second pulse Maxi
124. l number and pay the purchase price We then supply you with your license number which will permanently enable the tracking sy stem and will permit updates to be installed for a period of 1 year What s included in the price The ANY maze software itself All updates to the system for a period of 1 year Technical support for a period of 1 year Extended Support When you purchase ANY maze we supply technical sup port and all upgrades for a period of 1 year To get support and upgrades after this period you need to purchase an extended support contract When you purchase an extended support contract we will supply you with a new ANY maze license number this will permit updates to be installed for a further pe riod of one year UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 0372015 72 Jugo basile MAZES for VIDEO TRACKING TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com FOR STUDIES OF Animal M nim a azes Anxiety and Stress for Video Tracking Memory and Learning Spatial Memory Activity and Exploration General The Animal Mazes manufactured by Ugo Basile are designed to give optimal results with any Video Tracking software This is achieved by high contrast colors grey white black or the NEW Ugo Basile Light Blue non reflective colors reflections are a common source of error in animal tracking Let s avoid them All maz
125. lateral Medulla Modulate the Pressor Response to Aversive Stress J Neurosc 32 6 2051 2061 2012 G Grande et alia Unaltered size selectivity of the glo merular filtration barrier in caveolin 1 knockout mice Am J Physiol 297 F257 262 2009 S Finotto et alia Asthmatic Changes in Mice lacking T beta mediated by IL 13 Intl Immunology 17 No 8 993 1007 2005 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 02 2013 40 UD ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com Rodent Ventilator Cat No 7025 General The 7025 Rodent Ventilator is a volume con trolled mechanical ventilator according to Star ling s ventilator method designed for use with rats guinea pigs mice and small birds The 7025 drive consists of a variable speed geared motor linked by a novel variable stroke mechanism to easily interchangeable cylinder piston assem blies In particular the 7025 can be equipped with 5 10 or 30ml cylinder piston assembly Its precisely regulated geared motor speed provi des the most accurate and reliable stroke rate con trol of any respirator available The operation of the 7025 may be paused by an external TTL logic signal The picture features a Rodent Ventilator 7025 together 3 with the 6025 for Cat Rabbit Main Features Best available Starling Pumps Interchangeable cylinder piston assemblies
126. lator 30ml See also our Anesthesia Systems series 21100 the ideal match to our Ventilators Bibliography R Rudz et alia Acute Myocardial Infarction Inhibits the Neurogenic Tachycardic and Vasopressor Respon se in Rats via Presynaptic Cannabinoid Type 1 Recep tor J Pharmacol Exp Therap 343 198 205 2012 A Andersen et alia Ischemic Preconditioning Reduces Right Ventricular Infarct Size through Opening of Mi tochondrial Potassium Channels Cardiology 123 3 177 180 2012 Y Kalam et alia Levosimendan Does Not Improve Cardiac Output or Blood Pressure in a Rodent Model of Propranolol Toxicity When Administered Using Va rious Dosing Regimens Intl J Toxicol 31 2 166 174 2012 D Bilbija et alia Protecting the heart through delive ring DNA encoding for heme oxygenase 1 into skele tal muscle Life Sciences 91 17 18 828 836 2012 G E Peoples et alia Autologous pump perfused rat hindlimb preparation for investigating muscle fun ction and metabolism in vivo Microcirculation accep ted article 2013 42 O2013 ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS VENTILATORS and GAS ANESTHESIA www ugobasile com Cat Rabbit Ventilator Cat No 6025 General The 6025 Cat Rabbit Ventilator is a volume control led mechanical ventilator according to Starling s ventilation method designed for use with cats rabbits and animals of similar size The 602
127. lepsia 49 2 334 339 2008 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 06 2013 90 TRANSFORMING IDEAS INTO INSTRUMENTS MISCELLANEOUS ECT LMD www ugobasile com Lesion Making Device Cat No 53500 General This compact solid state DC Lesion Maker has been designed for the production of localized le sions in small animals when direct current DC is preferred to RF If features a regulated power supply combined with a constant DC current generator which operates on either continuous or timed mode The Lesion Making Device provides constant DC current in mA from 10 uA to 99 mA The pulse du ration may be timed by the instrument between 1 and 99 seconds or manually controlled The current generator is protected against short circuit preventing the electronics to get damaged due to the electrodes coming accidentally in con tact with each other Particular emphasis has been placed in the design of a good circuit output ground insulation this feature also minimizes spurious current field lines across the tissue outside the pattern preset by the operator Main Features Violation warning circuit Current Range from 10 pA to 99 mA 3 modes of Operation A precision New Model instrument which provides constant DC currentin mA Digital setting of constant current and time duration Pulse Duration timed between 1 and 99 seconds
128. lete with catch pan amp sli ding door assembly 40553 Mouse Cage complete with catch pan amp Sliding door assembly 40500 005 Expansion Box for multiple cage set up Specifications Latency Time 5 digit Read Out 0 1s steps Door Delay 0 99s in steps of 1s Shock Duration 0 1 9 9s in steps of 0 1s Shock Intensity 0 1 9 9mA in steps of 0 1mA CutOff Time 1 600s in steps of 1s Physical Weight 2 7Kg 40500 001 5 3Kg 40552 3 4Kg 40553 Shipping Weight Akg 40500 001 9Kg 40552 5 8Kg 40553 Packing 80x60x44cm Control Unit amp one cage Bibliography Papers which quote Ugo Basile P A Test step through C l Navarro Franc s et alia Influence of trait anxiety on the effects of acute stress on learning and retention of the passive avoidance task in male and female mice Behav Processes 105 6 14 2014 L Zvejniece et alia The cognition enhancing activity of E1R a novel pos itive allosteric modulator of sigma 1 re ceptors Br J Pharmacol 171 3 761 771 2014 RW Flint et alia NMDA receptor antagonism with MK 801 impairs consolidation and reconsolidation of passive avoidance conditioning in adolescent rats Evidence for a state dependent reconsolidation effect Neurobiology of Learning and Memory 101 114 119 2013 G Telegdy et alia The action of kisspeptin 13 on passive avoidance learning in mice Involvement of transmitters Behav Brain Res 243 300 305 2013 V
129. loli et alia Adrenergic Regulation of Vascular Smooth Muscle Tone in Calf Digital Artery J Vet Phar macol Therap 27 4 247 254 2004 F Carpi et alia Electromechanical Characterisation of Dielectric Elastomer Planar Actuators Comparative Evaluation of Different Electrode materials and Diffe rent Counterloads Sensors and Actuators 107 85 95 2003 P Tucciet alia Cyclo Oxygenase and Capsaicin Sensi tive Afferent Fibres Affect Beta Adrenoceptor Evoked Response in the Rat Urinary Bladder Pharmacology 64 57 62 2002 P C Moser et alia SL65 0155 A Novel 5 Hydroxyt ryptamine4 Receptor Partial Agonist with Potent Cognition Enhancing Properties J Pharmacol Exper Therap 302 2 731 741 2002 P Tucci et alia Effects of Natural Tachykinins on Ovi ne Lower Urinary Tract Smooth Muscle J Autonomic Pharmacol 21 2 79 84 2001 C M Q Jesus Morais et alia Yangambin a Lignan Ob tained from Ocotea duckei Differentiates Putative PAF Receptor Subtypes in the Gastrointestinal Tract of Rats Planta Med 66 4 211 216 2000 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 03 2013 86 ugo basile a RANSFORMING IDEA AS INT www ugobasile com DataCapsule Evo Digital Recorder Cat No 17304 General The new DataCapsule Fvo powered by iWorx is a new general purpose four channel data acquisition system that provides h
130. m Holders for orofacial stimu lation see separate leaflet Physical Universal Mains 85 264 VAC 50 60Hz 20 W max Total Weight Kg 12 5 Packing 98x49x47cm Shipping Weight Kg 21 approx Bibliography R Lu A Schmidtko Direct Intrathecal Drug Delivery in Mice for Detect ing In Vivo Effects of cGMP on Pain Pro cessing Methods in Molecular Biology 1020 215 221 2013 Q Russe et alia Activation of the AMP Activated Protein Kinase Reduces Inflammatory Nociception Journal of Pain 2 2013 J Btesh et alia Mapping the Binding Site of TRPV1 on AKAP79 Implications for Inflammatory Hyperalgesia J Neuroscience 33 21 9184 9193 2013 V Br zda et alia Dynamic Response to Peripheral Ner ve Injury Detected by In Situ Hybridization of IL 6 and its Receptor mRNAs in the Dorsal Root Ganglia is not Strictly Correlated With Signs of Neuropathic Pain Mo lecular Pain 9 42 2013 D Piomelli et alia Anandamide Suppresses Pain Initia tion Through a Peripheral Endocannabinoid Mechan smsm Nature NSC 2010 P J Austin et alia G Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats JoVE 61 e3393 doi 10 3791 3393 2012 http www jove com video 3393 chronic constriction sciatic nerve pain hypersensitivity testing UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 02 2013 14 ugo basile TRANSFORMING I
131. m s e Platform diameter 10cm Manual or Automated Modes The platforms go up and down in steps of 1 cm for a total vertical travel of 10 cm Different operation modes are possible using Ugo Ba sile Atlantis platform system in the manual mode the vertical travel is controlled by simply depressing a key In the automated mode the platforms can be operated by external triggers TTLs controlled by any videotra cking software No 40100 Each platform can be kept submerged and raised auto matically when the animal swims above it This protocol allows one to exclude from the test navigation strate gies in which spatial memory is not involved plaftorm up gt When used as stand alone tool without motor control ler the Atlantis hydraulic plat form 40101 002 can also conve niently replace Standard fixed platforms 4 platform down Ordering Information 40100 Complete 1 Platform System including standard components as listed below 40400 Complete 1 Platform System including standard components as listed below 40100 40400 40100 001 4 Channel Controller 1 1 40101 002 Platform 1 4 40101 003 Motor 1 4 40101 320 Connection Cable 1 4 40101 321 100ml Syringe 1 4 40101 322 Stretch of Tube 3m 1 4 40100 302 Instruction Manual 1 1 E WP 008 Mains Cable 1 1 Available Accessories 40101 Additional platform and motor assembly Ask for information about our Water Mazes and ANY maze videotracking
132. methods are currently available for orofacial pre clinical research and none incorporates parallel measu rement of mechanical or thermal stimulation within the same experiment Moreover while most of the current assays measure un learned behaviors such as flinching or withdrawal refle xes the new Orofacial Stimulation Test developed by Fehrenbacher Henry and Hargreaves integrates higher order brain functions into measurements of orofacial nociception This innovative approach permits highly integrated no ciceptive responses to thermal or mechanical stimula tion Animals are trained amp tested in standard home cages The snout is inserted through an opening to lick the re ward bottle Tests are performed in the presence of ther mal or mechanical stimuli contacting the vibrissal pad Following treatment to induce hypersensitivity e g trigeminal ligation or injection trials are repeated to determine the effect of treatment on feeding behavior reward Assay sensitivity inflammation induced decre ases in feeding behavior and reversal of hypersensitivity by local and systemic administration of analgesics has been proven Hargreaves et alia ms in prep the fee ding behavior is strongly correlated to mechanical or thermal orofacial nociception as the animal must con tact the stimulator in order to access the food reward The Ugo Basile Orofacial Stimulation Test quantifies fe eding behavior by measuring and rec
133. n Delays J Pharmacol Exper Therap 312 710 717 2005 S Ruiu et alia Synthesis and Characterization of NESS 0327 a Novel Putative Antagonist of the CB1 Cannabinoid Receptor J Pharmacol Exper Therap 2003 D Licheri et alia Long Term Voluntary Ethanol Consumption Induces Impairment of the Me chanical Performance in the Papillary Muscle of Sardinian Alcohol Preferring Rats Alcohol and Alcoholism 36 1 44 47 2001 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 04 2013 80 ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS General Neurotransmitter release is the major step of neuro transmission Abnormalities in neurotransmitter re lease have been proposed to be involved in many pathological conditions Therefore understanding the physiological mecha nisms of transmitter release and how the process can be modified by pathological states is essential to develop therapeutically useful pharmacological agents UGO BASILE 14900 Superfusion System has been especially designed to perform release studies from synaptosomes although brain slices can be employed as well On the other hand presynaptic nerve terminals are the sites where release specifically occurs therefore superfusion of synaptosomes is best suited to ex plore presynaptic events Superfused synaptosomes are the preparation of choice to study release regulating presynaptic re ceptors and t
134. nects to the mains or can be battery operated A foot pedal switch is provided for manual score of the peak force Fa F AOs 01010 Data Monitoring and Storage The device includes as standard both a control unit with internal memory and the NEW DCA software for signal monitoring data transfer and analysis Once saved data can be browsed on the control unit and or trasferred to a PC in proprietary Excel xls or text txt format to be managed by most statistical analysis packages available on the market T FR Des alee p Pure iri Acknowledgements The PAM was invented and validated in the University of Edin burgh by the team of Prof Daniel McQueen Susan Bond and colleagues and Dr Harry Brash who built the first prototypes Ordering Information 38500 PAM standard package including the fol lowing components 38500 001 Electronic Unit 38500 002 Large Joint Transducer 38500 003 Small Joint Transducer 38500 011 DCA Software on USB Key 38500 302 Instruction Manual on USB Key 38500 303 Pedal Switch All components lodged in a dedicated plastic case Options 38500 006 Paw Transducer 38550 PAM high pressure model for large animals Physical Weight 1 4 Kg in the plastic case Shipping weight 2 7 Kg Packing 46x38x27cm Shipping Weight 27 50 Kg approx Bibliography e Method Paper N J Barton et al A novel behavioural tech nique for measuring hypersensitivi
135. ng quantity amp frequency of food drink uptake activity with optional R motion detectors and excretion the latter assessed by volume or weight see following subheading For all types of investigations on METABOLISM including drugs which produce anorexia thirst arousing and quenching mechanism addiction aversion to particular feeding habits and their modification brought about substances by environmental conditions More than 10 000 publications about us METABOLIC CAGES Basic Cage Design These carefully engineered metabolic cages are manu factured by TECNIPLAST GAZZADA see separate da tasheet All components below the cage floor are removable wi thout upsetting the test animal Feeding and Drinking Analysis The basic Metabolic Cages are upgraded with the addi tion of miniature scales which accurately record inge stion of food The trough shaped as an open box is made of smooth gnaw proof plastics It glides into a receptacle made of stainless steel fastened to its scale pan which sen ses the load of the pellet food and hence monitors the quantity and frequency of food uptake The crumbs the animal produces are collected in the front compart ment for a precise evaluation of the food consumption The water bottles are provided with a spout and rest on a support stud fastened to the scale pan for monito ring quantity and frequency of water uptake Provision is made to collect an
136. ng in darkness etc None 010 010 Seen ANY maze has been designed to work with modern computers running Win dows Vista Windows XP Windows 7 P l However that doesn t mean you can t Meeg A use it with older equipment or other versions of Windows check computer compatibility on our web site Ordering Information 60000 ANY MAZE LICENSE including technical support and updates for 1 year 60050 ANY Maze 1 year support extension 60000 FC ANY Maze Freezing detection only for Fear Conditioning 47400 030 USB Camera with 2 1 amp 4 3 lenses visible block filter cables and ceiling support 47400 010 Black and white high sensitivity videoca mera including varifocal day amp night lens amp ceiling support 47400 011 Analogue Digital Converter PCI RTV24 4 channels for connection of 47400 010 to desktop PC Complete kit including cables 47400 012 Analogue Digital Converter FireWire 1 channel for connection of 47400 010 to laptop PC Complete kit including FireWire adaptor cables amp power supply ANY maze License How ANY maze licensing works You can download ANY maze from this site for free and install it on any number of computers You only need a license for copies which will be used for tracking you can use other free copies to set up experi ments analyse results transfer data etc To license a copy of ANY maze so you can use it for tra cking you supply us with its seria
137. ng it to the MULTIFUNCTION PRINTER Cat 2600 a microprocessor controlled device designed to acquire data from 6 independent channels The data stored in the 2600 internal memory and shown on its graphic display can be printed out in real time and or routed to the PC via the 52050 01 DAS Software Pack age provided with the 2600 package The 52050 is a Windows based Data Acquisition Soft ware Package which enables the research worker to store the data into individual files ready to be easily managed by most statistical analysis packages availa ble on the market No 6650 Special Model for Videotracking A special model of Mouse Hole Board is also available with no electronics ideal for Videotracking The 46653 is a simple open field dimensioned 40x40cm with 16 holes diam 3cm spaced 10cm apart from cen ter to center enclosed in transparent or opaque walls A similar model the 46652 is also available dimensio ned 1mx1m 35cm high 16 holes diameter 3 8cm to test rat exploratory behavior In alternative the standard 6650 can be connected to a PC parallel port via the optional cable 46650 330 to ac quire the number of pokes via ANY maze and combine them with data collected by the videotracking software Ordering Information 6650 HOLE BOARD standard package including 6651 Control Unit 6652 Board 6655 Instruction Manual on CD E WP008 Mains Cable Physical Power 115 or 230V 50 60Hz 15W ma
138. ntrol board the inter face with the external electronic unit and the interface with the video tracking software ANY maze not included Each arm may be limited in length by the use of spacers provi ded The corridor side walls made of plastic material are easily removable for cleaning purposes Moreover it will be easy to switch from high profile to low profile wall optinal according to the research needs System Configurations 41503 Y Maze for Mouse 1 41500 001 Central Control Unit 3 41500 002 Standard Arm with automated door 1 41153 010 Electronic Unit 8 TTL outputs Arm dimensions Length 35cm Width 5cm Height 12cm An automated door is provided on each arm at the central are na end 41504 T Maze for Mouse 1 41500 001 Central Control Unit 3 41500 002 Standard Arm with automated door 1 41500 003 Start compartment with automated door 1 41153 010 Electronic Unit 8 TTL outputs No 41500 Arm dimensions Length 35cm Width 5cm Height 12cm An automated door is provided on each arm at the central are na end the additional start compartment with automated door attached to the end of the stem arm completes the T Maze configuration 41508 8 Arm Radial Maze for Mouse 1 41500 001 Central Control Unit 8 41500 002 Standard Arm with automated door 1 41153 010 Electronic Unit 8 TTL outputs Arm dimensions Length 35cm Width 5cm Height 12cm An automated door is p
139. ntrolled unit The experimen tal data stored in its internal memory can be directly exported to the PC USB or serial ports Communication is managed by the dedicated CUB Data Ac quisition Software Package Cat 52050 12 included as stan dard The CUB Windows based Software Package enables the user to route the experimental data to the PC and store them into individual files to be managed by most statistical analysis packages available on the market No 37450 The 37450 is provided with a memory key to record all the ex perimental data of one or more sessions and to program the experiment layouts from a remote PC Ordering Information 37450 DYNAMIC PLANTAR AESTHESIOMETER complete with following standard accessories 37450 001 Microprocessor controlled electronic unit with USB key 37400 002 Touch stimulator 37000 003 Large platform 37400 327 Supporting Columns 37450 005 Framed testing surface perforated plat form 37000 006 Modular animal enclosure 3 to 12 spaces 37450 302 Instruction manual on USB key 37400 321 Set of two 0 5mm diam NiTi alloy filaments two calibration weights 5 amp 50 g and accesso ries in a plastic case E WP 008 Mains Cord 52050 12 CUB Data Acquisition Software Package with USB Connection Cable Optional 37000 145 Panel Mount Thermal Printer 57145 Thermal MiniPrinter 37450 278 Additional stimulation base with perforated platform and animal enclosure 37100 Set of two Durha
140. o explore the intimate mechanisms of neurotransmitter release Main Features Synaptosomes RAITERI S METHOD Release Studies Specifically designed to perform release studies from synaptosomes Brain slices can be employed as well More than 300 full papers using superfused synaptosomes have been published 81 SUPERFUSION SYSTEM Introduction UGO BASILE 14900 Superfusion System is a semi auto mated version of that originally developed in Raiteri s laboratory where about 200 papers have been publi shed exploiting the technique We have developed this Superfusion System in order to make commercially available an instrument in which the original design of the superfusion chambers has re mained intact The 14900 Superfusion System consists of 12 parallel open superfusion chambers with 12 upper reservoirs all thermoregulated by a water jacket Prewarmed oxygenated media of the desired composition can be concomitantly delivered from the reservoirs to the su perfusion chambers Synaptosomes are accomodated as very thin layers on microporous filters placed on glass filter supports Superfusion is provided by a multi channel peristaltic pump and superfusate samples are directly collected into scintillation vials Ordering Information 14900 SUPERFUSION SYSTEM Raiteri s me thod standard package including 14900 001 Electronic Unit 14900 002 Superfusion Bath Complete Assem bly in
141. oder 7010 7003 7004 7005 Excitation 6V 6V 6V 6V Voltage max Excitation 3V 3V 3V 3V Voltage typical ee uV per g per V Non linearity amp 3 3 3 3 Hysteresis Force Range 0 800 mg Overload 5g 20g 50g 200g Rating Moment of 7gcm 7gcm 7gcm Z7gcm Inertia Lever Arm 0 5 0 3 0 1 0 06 Displacement mm g mm g mm g mm g Physical 270g 270g 270g 270g Shipping 900g 900g 900g 900g Weight Compatibility Before ordering check the connection compatibilit of your amplifier recording system The Isometric amp Isotonic Transducers are normally sup plied with a connector designed for Ugo Basile Data Capsule Evo Recorder see datasheet If the customer wishes to make use of other recording apparatus the transducers can be supplied with appro priate connectors on request we will be glad to provide transducer with different connectors if available or to provide wiring information and instruction No 7003 7004 7005 amp 7010 Ordering Information 7003 Isometric Force Transducer type DY1 7004 Isometric Force Transducer type DY2 7005 Isometric Force Transducer type DY3 7010 _ _ High Sensitivity Transducer type DYO Bibliography Isometric Transducers 7003 7004 7005 H Ellers et alia Pungent General Anesthetics Activate Transient Receptor Potential A1 to Produce Hyperal gesia and Neurogenic Bronchoconstriction Anesthe
142. ol Of Aging 35 4 906 915 2014 M Milanese et alia Knocking Down Metabotropic Glu tamate Receptor 1 Improves Survival And Disease Pro gression in the SOD1 34 Mouse Model of Amyotrophic Lateral Sclerosis Neurobiol of Disease 64 48 59 2014 JE Lorenz Oxidant Induced Activation of cGMP De pendent Protein Ki nase la Mediates Neuropathic Pain After Peripheral Nerve Injury Antioxi dants amp Redox Si gnaling Jan 2014 J N Justice et alia Battery of Behavioral Tests in Mice that Models Age Associated Changes in Human Motor Function Age Oct 2013 R Gunther et alia Clinical Testing and Spinal Cord Re moval in a Mouse Model for Amyotrophic Lateral Sclero sis ALS JOVE J Vis Exp 61 e3936 doi 10 3791 3936 2012 C D Heldermon et alia Development of Sensory Motor amp Behavioral Deficits in the Murine Model of Sanfilippo Syndrome Type B PLoS ONE 8 e772 2007 rocking UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 01 2014 32 MOTORY COORDINATION ACTIVITY GRIP STRENGTH www ugobasile com Rotometer Cat No 43000 General The Rotometer is widely used in research on motor assessment tests in traumatic and acquired brain injury research and spinal cord injury research There are several well characterized causes for ani mals to exhibit rotational behavior Uneven unilateral higher expression of le vels of neurotran
143. omatically recorded Main Features Automatic detection of the animal Comfortable unobstructed working surface no response protruding elements Data portable to USB pen drive Excellent reproducibility thanks to optics lodged stick or to PC USB in a rigid structure amp electronically controlled I R flux Ugo Basile more than 10 000 citations TAIL FLICK UNIT Instrument Description The instrument components are neatly arranged in a box of new design which contains the I R source the sensor the microcontroller and the electronic circuit When the counter stops the display remains frozen on the indicated time Latency time is thus automatically recorderd An inclined Mouse Restrainer is supplied as optional to be used with the mouse to compensate for its ten dency to hold its tail at 45 degrees up and therefore away from the heat source In fact the availability of mice with specific gene s knock outs is driving a substantial shift from rats to mice as a research animal of first choice eo A roo Data Acquisition The 37360 is a microprocessor controlled unit The ex perimental data stored in its internal memory can be directly exported to the PC USB or serial ports Communication is managed by the dedicated CUB Data Acquisition Software Package Cat 52050 09 included as standard The CUB Windows based Software Package enables the user to route the experimental data to the PC an
144. on ANIMAL i Withlarge platform SENSITIVITY TO k Aesthesiometer Modularanimal LIGHTTOUCH 4 cage for Mice amp Rats OF THE PAW Cat No 37450 General The Dynamic Plantar Aesthesiometer has been designed to assess touch sensitivity on the plantar surface of the ro dents Somaesthetic mechanical stimulation has a long history of effective clinical use to diagnose pathologies of hyper or hypo aesthesia brought about by drugs neural pathology or experimental lesions etc in model and experimental systems using laboratory animals e 5 i Bi i _ a E ae l Main Features Automatic detection of animal Software included as standard response Data Portability via the Memory Key provided with the Consistent application of force at standard package an adjustable rate force ramp Print out by optional panel mount or independent thermal mini printer Ugo Basile more than 10 000 citations DYNAMIC PLANTAR AESTHESIOMETER The 37450 encompasses a movable touch stimulator unit complete with filament actuator and adjustable angle mirror a microprocessor controlled electronic unit of new design provided with graphic display internal me mory for data storage memory stick and optional printer a large testing surface a modular animal enclosure in which the 3 spaces can be further divided into 2 or 4 by removable par tition
145. on of improvement or impai Multiple Cage Set Up to study memory amp 1 rment in memory and learning processes learning processes p cotton Sette es iien CATACOLE Main Features NEW on the 2014 version The electronic unit encompasses all The new launcher application makes it possible to controls for up to 4 animal cages manage other UB behavioral cages with the same Touch BOKER Palace A EA cian Screen Controller 40500 001 just purchase the hardware ere ae g and the application software for the additional test Latency time recorded down to 0 1 Remote Control feature will make remote service and seconds software upgrades extremely simple 59 PASSIVE AVOIDANCE Step Down Instrument Description Different set ups depending on the number of cages can be obtained by combining the following elements Programming Recording Unit with Shocker Mouse Cage up to 4 with one controller Expansion Box for multiple cage set up Programming Recording Unit The 40500 001 Programming Recording Unit encom passing all controls incorporates a constant current high precision 8 pole shocker and manages data acquisition data are stored inside the unit and can be downloaded via the USB key provided as standard for further processing via Excel Access etc The Unit incorporating a 12 touch screen manages the Passive Avoidance Test via the 40570 010 Software Up to 4 cages can b
146. or tem changes as the time required to freeze deep struc ture of the brain may range from 10 90 seconds post mortem changes will occur during this period An alternate method is microwave heating to inactivate enzymes The microwave method has several advantages over cooling or freezing The enzymes in the whole brain can be completely inactivated in a very short time The brain can be dissected easily and reproducibly at room temperature Microwave fixation system must satisfy the following criteria 1 elevate the temperature of brain up to 75 90 C as rapidly as possible by effectively focusing micro wave energy on the animal head 2 give the same results from animal to animal 3 be easily and safely used by personnel not expe rienced in microwave Instrument Description Thanks to Patented Microwave Focus Applicators mi crowaves are channeled and focused by the wave gui de from above the head rather than in front The entire animal head is placed in a uniform microwave field Mo vements of the head do not change the field strength or microwave distribution Whole brain Ventral View MICROWAVE FIXED BRAIN Dissected brain parts Coronal section at Optic Chiasma Uniform fixation of the whole brain is thus achieved wi thout over cooking and damage to the hypothalamus Muromachi s unique applicators provide protection to the researcher and also compensate for individual dif ference
147. or Meas urement of Analgesic Activity on Inflamed Tissue Arch Int Pharma codyn CXI No 4 409 419 1957 REFERENCE TO UB ANALGESY METER RAT EK Joseph et alia Vascular Endothelial Cells Mediate Mechanical Stimu lation Induced Enhancement of Endo thelin Hyperalgesia via Activation of P2X2 3 Receptors on Nociceptors J Neuroscience 33 7 2849 2859 2013 L Ferrari et alia Role of Nociceptor a CaMKII in Transition from Acute to Chronic Pain Hyperalgesic Priming in Male and Female Rats J Neuro science 33 27 11002 11011 2013 D A Andersson et alia TRPA1 Has a Key Role in the So matic Pro Nociceptive Actions of Hydrogen Sulfide PLoS ONE 7 10 46917 2012 K Kir ly et alia The Dipeptidyl Peptidase IV CD26 EC 3 4 14 5 Inhibitor Vildagliptin is a Potent Antihyperalge sic in Rats by Promoting Endomor phin 2 Generation in the Spinal Cord Eur J Pharmacol 650 195 199 2011 Zs Helyes et alia Involvement of Transient Receptor Po tential Vanilloid 1 Receptors in Protease Activated Recep tor 2 induced Joint Inflammation and Nociception Eur J of Pain 14 4 351 358 2010 REFERENCE TO UB ANALGESY METER MOUSE K Sugimoto et alia The Impact of Low Dose Insulin on Peripheral Nerve Insulin Receptor Signaling in Streptozotocin Induced Diabetic Rats PLoS ONE 8 8 e74247 2013 MJ Hussey et alia Deletion of the Adenosine A2A Re ceptor in Mice en hAnce
148. ording the beam break number and duration including min max and mean via the ORO Software included the software ac quires data from up to 16 cages simultaneously Interface 1 f Cage 1 interface 1 Cage 2 interface 1 Cage 3 interface 1 i Cage amp Test 2 reached the end Test 3 reached the end Testing 00 00 13 Test 4 reached the end Orofacial Software testing window The Data are shown in real time both as numeric sum mary results and in a graphic format Data are automa tically analyzed across time according to an adjustable time window independently viewable for each of the 16 cages The results of all the tests are available in a spre adsheet format which can easily be copied to other pro grams for further analysis Either the thermal or the mechanical stimulator is mounted onto a stimulation detection wall which also incorporates a drinking bottle and fits inside stan dard rat home cages e g Tecniplast or Allentown The thermal stimulator relies on a copper tubing loop and a circulating water bath whose temperature can be adjusted from ambient to 70 C to reach hot nociceptive thresholds Chin inserts are included to test ani mals of different size The mechanical stimulator relies on thin wires attached to a mounting plate The system comes with several plates each with a different number of wires in order to apply different for ce levels to the animal vibrissal pad
149. oved to be of great value in research involving screening of drugs which are potentially active on motory coordination The Ugo Basile Rota Rods the original Rota Rods are the result of many years of research in cooperation with the latest development in behavioral and pharmacological research The Rota Rod technique is essential in scre ening drugs which have side effects on motor coordination The new Rota Rod for Mice has five lanes and operates in constant speed accelerating and reverse rocking modes The tiltable digital pa nel shows accrued rotations and time on the rod Main Features Adjustable speed 2 80 rpm and accelleration ramp 6 600 Tiltable graphic display for optimal reading MOTORY COORDINATION ACTIVITY GRIP STRENGHT THE ORIGINAL ROTA ROD THOUSANDS OF CITATIONS SINCE THE 1960s THREE OPERATION MODES CONSTANT SPEED ACCELERATING OR ROCKING PC Interface serial and USB via the adaptor provided Computer compatibility direct connection to PC via the dedicated software included as standard Ugo Basile more than 10 000 citations MOUSE ROTA ROD Basic Features The new Ugo Basile Rota Rod replaces both previou sly available constant speed and accelerating models It basically consists of five 3cm diam drums suitably machined to provide grip Six flanges divide five 5 7cm lanes enabling five mice to be on the treadmill simul t
150. pe feature ensuring the desired force is applied at a consistent rate 0 Das taimne m r Device Control Panel a i omnea i a coe TD TD navia EET ENT Anshis Control Panel b i i i t 1 i r i i t al u A d o Pure inte NEW Software acting as a quality control tool by showing the applied pulling force red line the desi red target force rate blue line and the peak detection in real time see picture above Instrument configuration The e VF comes as a complete package including touch stimulator transducer with prism electronic unit with po wer supply foot pedal software amp USB cable The mesh grid with platform and animal enclosure are optional Ordering Information 38450 e VF Electronic Von Frey complete with fol lowing standard parts 38450 001 Electronic Unit with power supply 38450 004 Touch Stimulator Transducer with 38450 310 Prism 38500 011 DCA Software on USB Key 38450 302 Instruction Manual on USB key All components lodged in a dedicated plastic case Options 37450 005 Perforated Metal Sheet for plantar stimulation 37450 278 Base assembly for plantar stimulation with per forated metal sheet amp animal enclosure Physical Weight 1 4Kg Shipping Weight 2 7Kg Packing 46x38x27cm UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 10 2014 18 ugo basile TRANSFORMING IDEAS INT
151. plete with magnetic switch and LCD counter The switch counts whole revolutions of the ac tivity wheel and operates on an extended life battery included Cages without counter models 1800 S and 1850 S are also available for data collection via PC see paragraph below Data Acquisition For data acquisition a Multifunction Printer is required This is a microprocessor controlled device designed to acquire data from 6 Cat 2600 independent channels each Activity Wheel requires 1 channel The data stored in the 2600 internal memory and shown on its graphic display can be printed out in real time and or routed to the PC via the CUB software pro vided as standard No 1800 When working with the Multifunction Printer the counter is not required so you may consider models 1800 S or 1850 S The picture above features a Multifunction Printer with the necessary multi connection cable 2610 F to connect up to 6 activity wheels Ordering Information 1800 Rat Activity Wheel complete with polycar bonate cage magnetic switch and LCD revo lution counter 1850 Mouse Activity Wheel complete with poly carbonate cage magnetic switch and LCD revolution counter 1800 S Rat Activity Wheel complete with polycar bonate cage amp magnetic switch without counter 1850 S Mouse Activity Wheel complete with poly carbonate cage amp magnetic switch without counter Multifunction Printers 2600 Multifunction Pr
152. pound 100ml bottle 7165 Connection tube cell reservoir amp drain vessel 37215 303 Hold Pedal Switch 52050 02 CUB Dedicated Software on USB drive 37140 302 Instruction Manual on USB drive 52010 320 USB to serial port converter 52010 322 Connecting cable 9 to 9 pin 4210 Three Claw Stand 10mm diam Upright com plete with 4003 Open Side Boss Head E WP 008 Mains Cord Also Available 37140 25 Plethysmometer complete with water cell diam 2 5cm amp standard accessories 37140 35 Plethysmometer complete with water cell diam 3 5cm amp standard accessories Other Available Water Cells 7157 Special Water Cell diam 2 5cm complete with Transducer 7153 L 7159 Special Water Cell diam 3 5 cm complete with Transducer 7153 L Optional 57145 Thermal Mini Printer 37400 305 Thermal Paper Roll for 57145 Specifications Power Requirement Universal input 85 264 VAC 50 60Hz 40 W max Data Read out multifunction graphic display Data Format 4 digits 2 integers 2 decimals Resolution 0 01 ml Commands via soft buttons Connection to PC direct connection to PC USB port via se rial cable and serial to USB adaptor Data Print Out via the optional MiniPrinter 57145 Physical Weight 4 8 Kg Shipping Weight 8 1 Kg approx Shipping Dimension 67x42x53cm Bibliography D Piomelli et alia Anandamide suppresses pain initiation through a pe ripheral endocannabinoid mechanism Na ture NSC 2010 F V
153. preference or aversion to the drug paired compartment hence rewar ding aversive properties of drugs can be easily deducted The CPP test only requires the animal to carry out a simple operation i e move from one compartment to the other to approach or avoid the drug paired compartment the ani mal is expected to spend more time in the drug paired com partment if the drug experience produced a positive effect Optimized For Video Tracking sajad padis All floors are grey colored to optimize contrast and facili tate tracking of both dark and albino animals Ordering Information 42502 CPP BOX for RAT including M TR 230 F 42502 011 42502 012 42502 014 42502 013 42552 320 Weight 42503 M TR 230 F 42503 012 42503 011 42503 013 42503 014 42553 320 Weight Floor Drawer 2 pcs Round 2mm holes 6mm interax 2 pcs Round 12mm holes 16mm iinterax 2 pcs Square 6x6mm holes 9mm interax 2 pcs Square 10x10mm holes 12mm interax 2 pcs Wall Context Kit for Rat Cage 22Kg net 25Kg gross Packing 80x60x44cm CPP BOX for Mouse including Floor Drawer 2 Round 2mm holes 3mm interax 2 pcs Round 4mm holes 6mm interax 2 pcs Square 4x4 holes 7mm interax 2 pcs Square 6x6 holes 9mm interax 2 pcs Wall Context Kit for Mouse Cage 8Kg net 10Kg gross Packing 36x55x45cm Acknowledgements amp Bibliography A special thank to Prof Paola Fadda Department of Pharma colo
154. purchase the hardware and the application software for the additional test The new launcher application makes it easy to manage other UB behavioral cages The remote control feature will make remote service and software upgrades extremely simple Ugo Basile more than 10 000 citations TOUCH SCREEN CONTROLLER No 40500 001 System Description Different set ups depending on animal rat or mouse type of behavioral test and number of cages can be ob tained by combining the following elements Programming Recording Unit with Shocker Behavioral Cage s up to 4 with one controller Expansion Box for multiple cage set up Isolation Cubicle s Box if required Instrument Description The 40500 001 Programming Recording Unit encom passing all controls incorporates a constant current high precision 8 pole shocker and manages data acqui sition data are stored inside the unit and can be down loaded via the USB key provided as standard for further processing via Excel Access etc The Unit incorporating a 12 touch screen manages the test via the dedicated application software see or dering info Up to 4 cages of the same type can be connected to the same Controller in this case an expansion box 40500 005 is required for each extra cage Launcher Menu Beside the buttons to select the desired application sof tware this menu features the following options Help Pressing th
155. r Maze 180 cm for rats 40193 Barnes Maze for mice 40192 Barnes Maze for rats 40142 Elevated Plus Maze for rats 40143 Elevated Plus Maze for mice 40163 Elevated Zero Maze for mice 40173 Y maze for mice 40172 Y maze for rats 40133 T maze for mice 40132 T maze for rats 47432 Open field 44 cm dark walls 47433 Open field 44 cm transparent walls 47100 Open field 100 cm dark walls 47150 Open field 100 cm with 4 partitions 74 UGO BASILE NORTH AMERICA www ugobasileusa com info ugobasileusa com TEL 1 484 973 6581 j ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS BEHAVIOUR MAZES TRACKING www ugobasile com MULTI MAZE SYSTEM FULLY CONFIGURABLE MULTI MAZE for Mouse Y T RADIAL MAZE OPTIMIZED FOR VIDEO TRACKING Cat No 41500 AND OPTOGENETICS The new MOUSE MULTI MAZE Cat No 41500 will help the researcher to conduct fully automated memory experiments such as Assessing spatial memory Testing basic working memory Discriminating working from reference memory Evaluating impairments in the working memory The electronic unit features USB interface 8 independent TTL inputs and integration with video tacking software The proprietary sliding doors retract in the maze floor ensuring unobstructed animal tracking while guaranteeing smo oth silent totally automated up and down movements All the animal mazes manu factured by Ugo Basile are designed with hi
156. ration of Ugo Basile Ventilators may be pau sed by an external TTL logic signal Start Stop Model For more demanding electrophysiological pharmaco logical investigations in particular when the operation of the Ventilator is software controlled a synchronised command is available to START STOP the Ventilator at completed forced inspiration Ask for special models 7125 Specifications Rate 10 to 180 strokes for minute Rate Read out digital display Stroke Volume 0 5 to 5 1 to 10 or 3 to 30 ml depending on cylinder piston Stroke Vol Scale 1 10 ml Stroke Vol Reprod 2 Universal input 85 264 VAC 50 60Hz 40 VA max Physical Dimensions 27x26x19cm Net weight 9 5Kg Shipping Weight 16Kg approx Packing 67x42x53cm UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 Ordering Information 7025 RODENT VENTILATOR complete with fol lowing standard accessories 7026 10ml Cylinder piston assembly complete 7032 Perspex Lid 7033 Lithium Grease Tube 7044 Y Canula 7025 302 Instruction Manual on CD E WP 008 Mains Cord Other available models and accessories 7025 5 RODENT VENTILATOR as above 5ml 7025 30 RODENT VENTILATOR as above 30ml 7128 5ml Cylinder piston assembly complete 7027 30ml Cylinder piston assembly complete 7025 150 Anesthesia Kit Models with synchronised START STOP feature 7125 Rodent Ventilator 10ml 7125 5 Rodent Ventilator 5ml 7125 30 Rodent Venti
157. roller will prompt to auto zeroing routine at every measurement to automatically adjust any offset Data Monitoring and Storage The device comes standard with both a control unit with internal memory and the new DCA software for signal monitoring data transfer and analysis Once saved data can be browsed on the control unit and or trasferred to a PC in proprietary Excel xls or text txt format to be managed by most statistical analysis packages available on the market Ease of use The GSM device has been designed to make sensitivity experiments easy and consistent thanks to its Effective peak detector for a reliable and automa ted detection of the animal response Ratemeter and Slope features ensuring the desi red force is applied at a consistent rate NEW Software acting as a quality control tool by showing the applied pulling force red line the desired target force rate blue line and the peak detection in real time The experimenter can consistently apply the force ier pull the animal at the desired rate by simply making sure that the red trace lays on the blue line see figure 1 Optional Grids Optional grids are available for integrated measure ment of the four limbs left or hindlimbs right Figure 1 Screenshot of the GSM software showing the force trace in red and the desired target force rate in blue slope function Ordering Information 47200 Grip Strength Meter n
158. rovided as standard Features and Benefits Software included NEW 2014 Release Grasping tools included for rats and mice grid is optional No calibration needed MOTORY COORDINATION ACTIVITY GRIP STRENGTH High Consistency for Rats with force rate monitoring tool for Mice Force rate monitoring via software or LCD display Grasping bar grasping trapeze positioned at adjustable height Maximum applicable force 1500g resolution 0 1g Ugo Basile more than 10 000 citations GRIP STRENGTH METER FOR RATS AND MICE No 47200 Rationale of the Grip Strength test When pulled by the tail the animal grasps at the bar Rodents instinctively grab anything they can to try to stop this involuntary backward movement until the pulling force overcomes their grip strength After the animal loses its grip on the grasping bar the peak am plifer automatically stores the peak pull force achie ved by the limbs and shows it on the display The instrument basically consists of a base plate of black sand blasted Perspex complete with a force transdu cer and a grasping device bar trapeze or the optional grid which can be positioned at an adjustable height The force transducer has a maximum applicable force of 1500g with a resolution 0 1g The transducer incorporates a proprietary memory chip to store all calibration parameters so that no further calibration is required for normal use moreover the cont
159. rovided on each arm The 41504 and 41508 configurations also enable the Y maze test to be carried out without any extra accessories Ordering Information Components 41500 001 Central Control Unit incorporating motor con trols and interface to external unit provided with 3 central arenas Y T radial 41500 002 Standard Arm provided with automated door and high profile 12cm h 41500 003 Start Compartment for T maze with automa ted door Arm 41153 010 Electronic Unit 8 TTL outputs 41500 310 ANY maze interface board Configurations 41503 3 Arm configuration for Y maze test standard profile walls automated doors 41504 3 Arm configuration and Start Compartment for Y maze and T maze test standard profile walls automated doors 41508 8 arm Radial Maze configuration for Radial and Y maze test standard profile walls auto mated doors UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 07 2014 76 IneEAG J ILCA T haid aa J ugo basile E General The Isolated Organ Baths have been designed for accurate recording of isometric or isotonic tissue contraction release Research involving effects of electrical stimuli or drugs on isolated organs uterus trachea vessel strips auricle can be performed under optimum conditions Wash or test solution enters the chamber after pas sing through the temperature equilibrating coils and the syringe v
160. s and provides a subject activity measurement MRI software allows for the use of the MRI sensor Ordering Information 015000 MouseOxPlus System Operation 110V 015001 MouseOxPlus System Operation 230V 015007 Premium Monitoring amp Recording Software 015017 MRI Module including Software 20 Sensor with 15 Copper Wire and 5 Fiber Optic 2 Mouse Thigh Clips 2 Rat Foot Clips 015002 Conscious Applications Module Sensors Two sensors selectable when ordering are included free of charge with each MouseOxPlus System CollarClip available in XS S M L XL 2XL size ThroatClip available in XS S M L XL 2XL size Mouse Thigh sensor Rat Foot Sensor Physical Dimensions 16x12x4 h cm Weight 2Kg Shipping Weight 5Kg approx Packing 50x39x17cm NOTE Manufacturer s warranty for MouseOx amp accessories is limited to 12 months 03 2013 ee ugo basile METABOLISM FEEDING BEHAVIOUR TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com o _ DESIGNED TO MEASURE Meta bo IC Cag es FEEDING BEHAVIOUR USB Connection activity oPtionaL Cat No 41800 1 2 3 EXCRETORY FUNCTIONS General The recently available animal models for example obese and diabetic mice exhibit symptoms similar to those in hu mans Model organisms are closely monitored revealing differences which can be correlated with those of the human disor ders in fundamental parameters as feeding drinki
161. s which respond to light touch of the paw when they feel it by a paw withdrawal reflex However the involved procedure is tedious and time consuming because several stimulations must be per formed for a single test i e a different filament for each force level Compared to the classic Von Frey Hairs the Electronic Von Frey e VF has the advantage of ensuring a conti nuous force application along the whole force range of the sensor 0 1000g by using a single rigid metal tip Moreover the metal tip used in the e VF is the same as the one used in the classic Ugo Basile Dynamic Plantar Aesthesiometer PN 37450 allowing consistent com parison of results among the two instruments Fig 1 touch stimulator transducer including prism Grid mesh not included optional see ordering information Data Monitoring and Storage The device comes standard with both a control unit with internal memory and the new DCA software for signal monitoring data transfer and analysis Once saved data can be browsed on the control unit and or trasferred to a PC in proprietary Excel xls or text txt format to be managed by most statistical analysis packages available on the market No 38450 Ease of use The e VF device has been designed to make sensitivity ex periments easy and consistent thanks to its Effective peak detector for a reliable and automated detection of the animal response Ratemeter and Slo
162. s Mechanical Ventilation Ensures Proper Depth of Anesthesia Titrates Supplemental Oxygen Features Immediate responding beat by beat measurements High accuracy at heart rates up to 900 BPM and bre ath rates up to 600 BrPM Drawing of blood is not required for any reason Simple non invasive sensor clip enables quick and easy attachment to the subject USB plug and play technology easily turns your Win dows based PC into a low cost physiologic monitor Monitor data in real time while recording to a file Experiment event markers allow the user to mark im portant events in the data file Enhanced signal processing ability improves respon se to the motion of conscious subjects UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 Standard Software and Options The Standard software includes basic monitoring and parameter alarms for all of the vital signs provided by the MouseOx Plus it is included with all MouseOx Plus sy stems and is intended for basic monitoring applications The Premium Monitoring amp Recording Software in cludes trending charts real time recording options file markers for noting important events and a quick avera ging diagnostic feature for spot checking The Conscious Applications Software includes enhan ced filters and control algorithms to allow the MouseOx Plus to monitor conscious unrestrained subject
163. s Spinal Cord Neurochemical Responses to an Inflammatory Noci ceptive Stimulus Neuroscience Letters 506 2 198 202 2012 M S Nash et alia 7 tert Butyl 6 4 Chloro Phenyl 2 Thioxo 2 3 Dihydro 1H Pyrido 2 3 d Pyrimidin 4 One a Classic Polymodal Inhibitor of Tran sient Recep tor Potential Vanilloid Type 1 with a Reduced Liability for Hy perthermia Is Analgesic and Ameliorates Visce ral Hypersensitivity J Pharmaco Exper Therap 342 2 389 398 2012 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 PAIN and INFLAMMATION www ugobasile com Hot Cold Plate Cat No 35100 General This new instrument with temperature presetable in the range 2 C to 66 C can be used as A conventional HOT PLATE to carry out a ra pid precise screening of narcotic type analge sic drugs according to the well known Hot Pla te Test devised by N B Eddy and D Leinbach AsaCOLD PLATE the Cold Plate Test is useful in studying cold receptors and cold allodynia a phenomenon very frequently observed in chronic pain on humans The two operating modes allow for testing at fixed temperature or at increasing decreasing tempera ture The latter experimental scheme is obtained by simply setting on the keypad starting and final temperature An optional auxiliary Hot Plate see figure 1 over leaf permits running two tests simultaneously Model 35200 Thermal Escape device is also a
164. s between animals giving more reproducible results Cat MMW 05 The Muromachi Microwave Fixation Systems are safely designed so that the microwave leakage will not exceed 1 mW cm2 well below the safety standards The Microwave Fixation System comes with specific ap plicator heads and water jacketed animal holders Ordering Information MMW 05 Microwave Fixation System 5KW inclu ding 1 Applicator head and 1 animal hol der to be selected Applicator heads TAW 174P for mouse holder TAW 424SP for rat holder WJR S TAW 424MP for rat holder WJR M amp L Water Jacketed Animal Holders WJM 24 for mice 15 20g WJM 28 for Mice 20 40g WJR S for Rats 150 250g WJR M for Rats 250 400g WJR L for Rats 400 500g TAW 174P for mouse holder TAW 424SP for rat holder WJR S TAW 424MP for rat holder WJR M amp L Physical Power 190 240VAC 30A or 380 440VAC 20A 3 phase Dimensions 75 w x55 d x128 h cm Weight 103Kg Shipping weight 195Kg Packing 81x100x132cm Bibliography 8B Sahin et alia Evaluation of neuronal phospho proteins as effectors of caffeine and mediators of striatal adenosine A2A receptor signaling Brain Research 1120 1 14 2000 P Svenningsson et alia DARPP 32 mediates se rotonergic neurotransmission in the forebrain PNAS 99 5 2002 e G L Caporaso et alia Drugs of abuse modulate the phosphorylation of ARPP 21 a cyclic AMP regulated phosphoprotein enriched in the basal
165. s ugobasile com TEL 39 0332744574 02 2013 28 ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com Rat Rota Rod Cat No 47700 General The Rota Rod technique has been origina ted by a 1957 paper of N W Dunham and T S Miya and has proved to be of great value in research involving screening of drugs which are potentially active on motory coordination The Ugo Basile Rota Rods the original Rota Rods are the result of many years of research in cooperation with the latest development in behavioral and pharmacological research The Rota Rod technique is essential in scre ening drugs which have side effects on motor coordination The new Rota Rod for Rats has four lanes and operates in constant speed accelerating and reverse rocking modes The tiltable digital pa nel shows accrued rotations and time on the rod Main Features Adjustable speed 2 80 rpm and accelleration ramp 6 600 Tiltable graphic display for optimal reading THE ORIGINAL ROTA ROD THOUSANDS OF CITATIONS SINCE 1960s THREE OPERATION MODES CONSTANT SPEED ACCELERATING OR ROCKING PC Interface serial and USB via the adaptor provided Computer compatibility direct connection to PC via the dedicated software included as standard 29 RAT ROTA ROD Basic Features The new Ugo Basile Rota Rod replaces both previously available constant speed and acc
166. seeees 63 42553 Conditioned Place Preference CPP for Mice o cececccccccceceeeccccecsseeceeeeseseseeeueeeseens 63 45100 Lickometer Vogel Test for Rats ssssesresessereerseeesrsesseessoeresrseserersssroeseseseereerersssesees 65 45150 Lickometer Vogel Test for Mice scsessescsssstoressessosersessussscscesessossstonscuessescesessens 65 BEHAVIOUR MAZES TRACKING 46503 Sociability Apparatus 3 chambered social test nc OF 40100 Hydraulic Atlantis Platforms for Morris water maze asserere 69 60000 ANY maze VideoTracking System see also WWW UD ANYMAZE COM sosse 71 40125 Morris Water Maze ussssseessssessersreereesreserssoeoresressessserresereeereseessesssesseeseeeereserseesreeesse O 40132 3 T Maze for Rats Mice c c ccccccecesececcecessecccecesecessesececeeceeeccesecestssseeeestttassesesstttsessteeee DD 40142 3 Plus Maze for Rats Mice u cc cececcsscceesesceecenscseceecensaeceseeecescstseesssttasestttseseestesteeee DO 40153 Radial Maze for Maze u ccccccccccccesssccccceesecsceecceseseeeesecceescecescssssseesseseststsessssssttecstetssene DO 40162 3 Elevated Zero Maze for Rats Mice ssssssssesssssesssssrssssrrsssrerrsssrrrsssrerrssrsrsrrnenrenn DO 40172 3 Y Maze for Rats Mice cceccceecessseceecesssccccceecessseececeeceseecesscsssseceecesesssecsesssttsstsstteeeee DD 40192 3 Barnes Maze for Rats Mice tears E N E E EE EA 13 40150 Open Fields for V
167. sesssesessee DL 51600 Stoelting Stereotaxic Instruments xnisicatsancuicaninvesicanisdiviniatisaeacesgenwtentooadsbetdncdsesiatouaesn J 5000 KDS Infusion PUMPS Seseonccerstvecscerteseacuisssceksescoridarnacsstusteuseonnceemetse etnias OO BLOOD PRESSURE VITAL FUNCTIONS 58500 Blood Pressure Recorder non Invasive for Rats cccccccesseeseseecceceesesceeeeseeeees 97 58600 Blood Pressure Recorder non Invasive for Mice ooo ccc ccccccccccccceeceecuseeceveseeeueveeues 97 17844 Blood Pressure Transducer INVASIVE cccccccccceccusceessescecececueecseceuaeeuseeeeeeesteceesens 99 MouseOx Starr MouseOx Pulse Oximeter ooo eee eeeceeccceeceecesssseeeseceesseessscseecsessaeececceseceseees 101 METABOLISM FEEDING BEHAVIOUR 41800 Metabolic Cages and Feeding Analyser o ccccccccccseecesesesteeseeeseeeseeeeesteseeeseee 103 47552 Rat Feeding amp Activity Analyser ccccccceccesesseeseeessceesestttetesestsesstecsseesteeseeeeee L05 47553 Mouse Feeding amp Activity Analyser cccccceccseeecseceseceeeeeeesesttteteeteseessesssereeeeee L05 MUROMACHI MICROWAVE FIXATION MMW 05 Muromachi Microwave Brain Fixation System s sssssssssssssssessessiersrerrrserrseresees 107 Ugo Basile more than 10 000 citations BROWSE PRODUCTS BY APPLICATION each caption is a link to the related web page NEUROPATHIC PAIN Analgesy Meter HYPERALGESIA INFLAMMATION Hor co ARa P A M Pressure Appli
168. signed for investigating isotonic contractions in isolated organs particularly smooth muscle amphibian hearts etc An lsotonic Transducer is basically a displacement meter under constant load whereas an Isometric transducer measures changes in force at constant length 85 ISOTONIC TRANSDUCER lsotonic Transducer Specifications Voltage Output Linearity Excitation Voltage Excitation Current Operating Range Lever Arm Length Lever Arm Travel Breakaway Torque Moment of Inertia Overall Dimensions Weight Shipping Weight Packing Compatibility 300uV per mm displacement of lever arm tip 2 to 15 rotation 6 gt 15V 20mA constant in the range G T3V 15 about the centre 10cm 6cm less than 0 1g x cm 35 g x cm 16 5x5 5x11cm excl remova ble handle 0 35Kg 1 60Kg 29x26x29cm Before ordering check the connection compatibility of your amplifier recording system The Isometric amp lsotonic Transducers are normally sup plied with a connector designed for Ugo Basile Data Capsule Evo Recorder see datasheet If the customer wishes to make use of other recording apparatus the transducers can be supplied with appro priate connectors on request we will be glad to provide transducer with different connectors if available or to provide wiring information and instruction No 7006 Ordering Information 7006 lsotonic Transducer Bibliography O E Kiroglu alia
169. sition Software Package Windows based which enables the research worker to store the data into individual files ready to be easily managed by most statistical analysis packages available on the market Ask for details 47800 COMBO PACKAGE FOR MOUSE amp RAT If you plan to work with both rats and mice you should consider the Com bination Package 47600 Mouse 47700 Rat Ro ta Rod offered at a special price 47600 Mouse Rot Roc a No 47700 Ordering Information 47700 RAT ROTA ROD standard package inclu ding 47700 320 Trip Plate complete 4 pieces 47700 321 Transmission Belt 2 pieces 47700 302 Instruction Manual on USB drive 52050 07 Dedicated Software Package on USB drive 52050 322 Serial Cable 52010 320 Serial to USB adaptor E WP008 Mains Cord Optional 57145 Thermal Mini Printer 47800 Combination Package 47700 Rat Rota Rod and 47600 Mouse Rota Rod Physical Universal input 85 264 VAC 50 60 Hz Dimensions 50 w x49 d x63 h cm Weight Kg 10 0 Shipping Weight Kg 18 0 approx Packing 80x60x44cm Bibliography Method Papers N W Dunham amp T S Miya A Note on a Sinple Appara tus for Detecting Neurological Deficit in Rats amp Mice J Am Pharmaceut Assoc Scientific Edit XLVI No 3 1957 B J Jones amp DJ Roberts The Quantitative Measure ment of Motor Incoordination in Naive Mice Using an Accelerating Rotarod J Pharm Pharmac 20 302 304 19
170. sm PLoS ONE 8 1 e55255 2013 M Arai et alia The miRNA and mRNA Changes in Rat Hippocampi after Chronic Constriction Injury Pain Me dicine 14 5 720 729 2013 PJ Austin et alia G Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats JoVE 61 e3393 doi 10 3791 3393 2012 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS PAIN and INFLAMMATION www ugobasile com RAPID and PRECISE h Ta F l f IC k y n it Dedicated Software SCREENING o 1 Memory Key included ANALGESIC DRUGS 7 ON THE RAT TAIL l Cat No 37360 General This new style Tail Flick Unit has been designed to perform rapid precise screening of analgesic drugs via heat stimulation on the rat tail according to D Amour amp Smith see bibliography It basically consists of an I R source whose radiant energy of adjustable intensity is focused on the rat tail by an embodied parabolic mirror The rat is held by the operator on the instrument unobstructed upper panel see picture in such a way that its tail placed over a flush mounted window receives the I R energy The operator starts the stimulus and the related solid state second counter When the rat feels pain and flicks its tail a sensor detects it stops the second counter and switches off the bulb The reaction time of the animal is thus determinedand aut
171. smitters such as GABA or dopamine Some brain tumors can cause aberrant expression levels to occur Injury may also interfere with proper neurotran smitter expression and or cause some lo calized change in neurotransmitter expres sion Developmental anomalies can also cause rotational behavior Anxiety stress may cause this aberrant be havior l Exposure to some drugs or drug abuse or No Tether x TRULY withdrawal from some drugs all may cause UNRESTRAINED rotational sequences 2 No Jacket MICE Physical lesions also can cause rotational 3 behavior in an animal Main Features No jacket or tether is necessary the animal is completely free Stand alone with internal memory Quick and simple to use no training turn key system with software included Ugo Basile more than 10 000 citations ROTOMETER Nowra 101010 Freely Moving Animals To quantify rotational behavior in a freely moving mou se is a significant development This new Rotometer accomplishes this task precisely using new and clever technology to count clockwise CW and counterclockwise CCW rotations in an open field The animal just carries a small magnet not much larger than a grain of rice on its nape or on its tail The magnet can be surgically implanted or injected subcutaneously however a convenient method is to attach it to the base of the mouse tail by using standard laboratory tape This easy and effi
172. ssible to manage other UB behavioral cages with the same Touch Screen Controller 40500 001 just purchase the hardware and the application software for the addi tional test The electronic unit encompasses all con Remote Control feature will make remote service and trols for up to 4 animal cages software upgrades extremely simple Ugo Basile more than 10 000 citations LEARNED HELPLESSNESS System Description Different set ups depending on animal rat or mouse and number of cages can be obtained by combining the following elements Touch Screen Controller with Shocker Rat Cage up to 4 with one controller or Mouse Cage up to 4 with one controller Expansion Box for multiple cage set up Programming Recording Unit The 40500 001 Programming Recording Unit encom passing all controls incorporates a constant current high precision 8 pole shocker and manages data ac quisition data are stored inside the unit and can be downloaded via the USB key provided as standard for further processing via Excel Access etc Step 1 Experiment Step 2 Conditioned Stimulus Step 2 Unconditionsd Stimulus Type of event o CONDITIONED Sound 5 43 74 25 2000rr Intensity 20 amp Stat s 20 0 amp sisarima Frequency Hz 2000 Stop s 23 0 Ge ustan ms ars Sound 110s 14 45 20 2002r ADD MODIFY DELETE Light 12 45 15 05 20 la ence CAGE 2 CAGES CAGE 4 basile V 1 0 1 14 9 22 2014
173. t is of gre at importance to measure accurately neuroche mical events in vivo However it is difficult to perform reproducible measurement of these events because rapid post mortem changes occur in the brain concen trations of metabolites and neurotransmitters With the NEW Microwave Brain Fixation System by Muromachi a living mouse or rat is positioned inside the applicator and in less than 1 second the microwave beam stops all brain chemistry at the level present in the living animal Measuring brain chemistry in vivo is possible THE FASTEST AND MOST EFFECTIVE KNOWN METH OD OF HALTING BRAIN CHEMICAL ACTIVITY Prior to analysis of Phosphorylated proteins Acetylcholine Serotonin Endorphins Prostaglandins Catecholamines C AMP C GMP GABA DOPA MUROMACHI MICROWAVE FIXATION brain fixation occurs in 1 second activity of degrading enzymes is blocked NEW features Improved usability touch screen Air cooled no water circulation CE certified Absolute safety negligible leakage Ugo Basile more than 10 000 citations Microwave Brain Fixation System Various techniques have been developed to prevent post mortem changes One of the more common me thod is cooling or freezing by immersion of the decapi tated head in liquid Nitrogen or cooled Freon to inac tivate enzymes involved in the metabolism of these compounds Cooling is not fully effective in preventing post m
174. te with following standard accessories 37370 001 Plantar Test Controller 37370 002 Emitter Detector Vessel with cable 37000 003 Platform 37370 327 Supporting columns 37000 006 Modular Animal Enclosure 37370 005 Framed Glass Pane 37370 302 Instruction manual on the USB key 52050 10 CUB Software USB key with USB cable E WP 008 Mains Cord Optional Spares amp Accessories 37000 145 Panel Mount Printer 37300 Heat Flux I R Radiometer E HR 002 Replacement Bulb 37370 278 Additional stimulation base complete with glass pane and animal enclosure 37100 Set of two Durham Holders for orofacial sti mulation see separate datasheet Physical Universal Mains 85 264 VAC 50 60Hz 20 W max Dimensions 85 x 40 x 35 cm assembled Weight 13 00 Kg Packing 98 x 49 x 47 cm Shipping Weight 27 50 Kg approx Bibliography Method Paper K M Hargreaves R Dubner F Brown C Flores amp J Joris A New and Sensitive Method for Measuring Thermal Noci ception in Cutaneous Hyperalgesia Pain 32 77 88 1988 D C Yeomans amp H K Proudfit Characterization of the Foot Withdrawal Response to Noxious Radiant Heat in the Rat Pain 59 85 97 1994 Papers mentioning UB model D Piomelli et alia Anandamide suppresses pain initia tion through a peripheral endocannabinoid mechanism Nature NSC 2010 A Finley et alia Sphingosine 1 Phosphate Mediates Hyperalgesia via a Neutrophil Dependent Mechani
175. the crossing takes place during the pau se records the intertrial crossing Ordering Information 40500 001 Programming Recording Unit amp Shocker 40530 010 P A Software and activation 40532 Rat Cage complete with catch pan 40533 Mouse Cage complete with catch pan 40500 005 Expansion Box for multiple cage set up Specifications Shock Duration in steps of 0 15 Shock intensity 0 3mA step 0 1mA Light intensity 0 100 in steps of 5 Sound intensity 0 100 in steps of 5 Sound frequency 100 18 000Hz in steps of 100Hz Light sound shock start in seconds 0 1s precision Light sound shock stop in seconds 0 1s precision Physical Weight 2 7Kg 40500 001 5 3Kg 40532 3 4Kg 40533 Shipping Weight 4Kg 40500 001 9Kg 40532 5 8Kg 40533 Bibliography Papers which quote Ugo Basile A A Test previous model D Dimitrova D Getova Effects of Rivastigmine on Learning and Memory Processes in Rats Active Avoi dance Test Medicine 4 1 2014 GN Carmona et alia The Dense Core Vesicle Protein IA 2 but not IA 2 B is Required for Active Avoidance Learning Neuroscience 269 6 35 42 2014 O Ortiz et alia Associative Learning and CA3 CA1 Synaptic Plasticity Are Impaired in D1R Null Drd1a Mice and in Hippocampal siRNA Silenced Drd1a Mice J Neuroscience 30 37 12288 12300 2010 J J Lemos et alia Involvement of the prelimbic pre frontacortex on cannabidiol induced attenuat
176. the hind paw A trial is started by depressing a key on the I R source When the animal feels pain and withdraws its paw the I R source switches off and the reaction time counter stops The withdrawal latency to the nearest 0 1s is au tomatically determined and recorded Data Acquisition The 37370 is a microprocessor controlled unit The ex perimental data stored in its internal memory can be directly exported to the PC USB or serial ports Communication is managed by the dedicated CUB Data Acquisition Windows based Software Package 52050 10 included as standard which enables the user to route the experimental data to the PC and store them into individual files to be managed by most statistical analysis packages available on the market The 37370 is provided with a memory key to record all the experimental data of one or more sessions and to program the experiment parameters from a remote PC Calibration Radiometer Each Plantar Test Unit is accurately calibrated via an Heat Flux I R Radiometer Cat 37300 The end user should consider this extremely useful op tional accessory which enables the experimenter to i Make sure that two or more units deliver thermal nociceptive stimuli expressed in mW per square cm of exactly the same intensity ii Measure the I R energy 1mW for the duration of 1s corresponds to 1mJ in absolute terms Ordering Information 37370 Plantar Test Hargreaves test comple
177. then reliably re turn the probe to the same point Convenient for Electrophysiology Integral brass bushings in the manipulator arm allow grounding directly to the closest metal on the manipu lator arm even the probe holder Selection of Accessories Species adaptors are available to fit rat cat monkey dog monkey mouse guinea pig and small bird Probe holders and species adaptors for U frame stereotaxic instruments from other manufacturers are generally compatible with the Lab Standard frame No 51600 Ordering Information 51600 51650 51653 51603 51601 Lab Standard w 18 Degree Earbars Lab Standard w 45 Earbars Dual Lab Standard Stereotaxic w 45 deg Ear Bars Dual Lab Standard Stereotaxic w 18 deg Ear Bars Lab Standard without Manipulator Arms UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 94 ugo basile MISCELLANEOUS ECT LMD TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com INFUSION PUMPS SO ADVANCED THEY RE SIMPLE by KDS Cat No 5000 General Ugo Basile presents an entirely new generation of micro processor controlled syringe pumps They are designed spe cifically for applications requiring high metering precision at low pulse free flow rates KDS pumps manufactured by KD Scientific Inc U S A provide a unique combination of sophisticated features and ad vanced microstepping motor drive technology The result
178. to PC via the 52050 Software included Read out multifunction graphic display Print out by optional thermal MiniPrinters 57145 Plethysmometer No 37140 Volume Measuring Water Cell The measuring cell consists of two vertical interconnec ted Perspex tubes the animal paw is dipped in the lar ger tube 1 8cm diam to measure water displacement A tube of smaller diameter 1 3cm is also included for measuring the mouse paw The smaller diameter side tube contains the transducer which measures the conductance between two vertical wire electrodes conductance is linearly proportional to the water level hence to the displaced volume Data Acquisition The 37140 Plethysmometer is microprocessor control led featuring direct PC output Internally stored data can be routed to the PC serial RS232 or USB port via adaptor Communication is managed by the dedicated Software Cat 52050 02 a Windows based Data Acquisition Sof tware Package The 52050 02 enables the data storage into individual files ready to be easily managed by most statistical analysis packages available on the market Ask for details Ordering Information 37140 PLETHYSMOMETER standard package including 7141 Electronic Block 7152 S Standard Water Cell diam 1 8cm including Mouse paw tube 7186 diam 1 3cm 7153 L Conductance Transducer 7140 154 Water Reservoir 7155 Calibration Probes 0 1 0 2 0 5 1 2 4ml 7160 Wetting Com
179. two or more Tail Flick Plantar Test Units deliver thermal nociceptive stimuli of exactly the same intensity Balance them if necessary Know the I R energy in absolute terms 1mW for the duration of 1s corresponds to 1 mJ A useful datum to compare with any equal or different method instrument described in the literature Principle of Operation This simple and reliable I R Radiometer uses miniatu re flat temperature gradient sensors whose output signal is proportional to the temperature difference between their top and bottom surface 1 Heat Sink 2 Temperature Gradient Sensor 3 I R Beam 4 Plastic Guard In fact the temperature reached by the top surface of the sensor attains few degrees Celsius over the heat sink temperature and hence involves negligible con vection and radiation losses At the equilibrium the I R power flux p mW per square cm is given by the formula b AT pd Where AT is the temperature difference between top and bottom surfaces of the sensor p is its thermal resi Stivity and d its thickness No 37300 It is notable that the determination of p is not affected by the heat sink temperature AT only comes into play The time constant of the system zeta i e the time to reach the equilibrium is given by the formula pdc where C is the thermal capacity of the sensor p d and C are very small which leads to the equilibrium and hence to the exact determination of the I
180. ty in a rat model of joint pain J Neurosc Methods 163 67 75 2007 e J Leuchtweis et al Validation of the Digital Pressure Appli cation Measurement PAM Device for Detection of Primary Mechanical Hyperalgesia in Rat and Mouse Antigen Induced Knee Joint Arthritis Methods amp Findings in Exp amp Clinical Pharmacol 32 8 581 589 2010 T Schwagarus et alia A New Method for Measuring CFA in duced Mechanical Hyperalgesia in the Rat Evotec 2012 e D Amorim et alia Amitriptyline reverses hyperalgesia and improves associated mood like disorders in a model of expe rimental monoarthritis Behav Brain Res 265 12 21 2014 e 38550 P Di Giminiani et alia Nociceptive responses to thermal and mechanical stimulations in awake pigs Eur J Pain 17 5 638 648 2013 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 10 2014 16 ugo basile RANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com e VF ELECTRONIC VON FREY Cat No 38450 General Ugo Basile introduces an electronic apparatus for applying light touch to the rodent foot the e VF Electronic Von Frey A touch stimulator transducer is mounted on a Per spex bar so that routine procedures may be emplo yed to examine and test the animal skin sensitivity A prism of proprietary design is a useful tool to lo cate and aim the stimulation area The completion of each test may be indic
181. urface with Von Frey filaments we offer a 90x38cm perforated me tal platform cat 37450 005 Laser cut perforations form a mesh like open grid of square holes 5X5 mm interve ning metal grid is 1mm wide comfortable to the animal and easy to view the target area of the paw The shelf is coated with a polymer resin that is easy to cle an and which will not be spoiled by fluids or waste mate rials Mount the shelf on the wall In alternative we offer a shelf with 40 or 80cm legs 37450 045 amp 37450 085 respectively which can be completed with our standard animal enclosure 37000 006 the latter is the modular enclosure used with out Plantar Test amp Dy namic Plantar Aesthesiometer in which the 3 spaces can be further divided by partitions into 2 or 4 thus lodging up to 12 rats or mice You might also consider the complete stimulation base 37450 278 including supporting columns shelf and ani mal enclosure Ordering Information 37450 275 Aesthesio Sensory Evaluator Kit of 20 Von Frey filaments in a carrying case Physical Weight 0 4 Kg Shipping Weight 0 9 Kg Packing 24x22x5cm Options 37450 005 Large Perforated Metal Platform testing shelf for plantar stimulation 37450 045 Platform 37450 005 with 40cm legs 37450 085 Platform 37450 005 with 80cm legs 37000 006 Multiple configuration animal enclosu re from 3 to 12 spaces 37450 277 Set of 20 VonFrey Filaments 37450 275 amp complete base assem
182. urham Holders are designed to hold an animal comfortably and effectievely They are made of a pro prietary polymer with a deep red color which appears dark to the animal The holders conformation is optimized to two specific animal size ranges the smaller holder will accommo date rats from 175 grams to 250 grams and the larger holder will accommodate animals from 225 grams to over 400 grams In practice the rat crawls in happily and becomes snu gly nestled within the holder Normally the rats don t back out but inserting the vertical back plate ensures that the animal stays in place The position of the removable back panel insert can be adjusted from slot to slot which allows the animal to be securely held in place without being crowded The rat crawling towards the front helps quite a lot and the subject is almost self positioning for applying the IR stimulus to the submandibular region of the rat face Access Panels There are two different windows through which the sti mulus may be presented Submandibular access panel The opening under the chin is a perfectly sized rectan gular aperture just below the animal s chin It allows the IR or mechanical stimulus to be aimed precisely and to stimulate the area innervated by the mandibular branch of the trigeminal nerve The aperture is large enough that both right and or left side may be individually stimulated Plantar access panel The holder allows the animal
183. use nose cone mask connected to an evacuation tubing No 21100 Induction Box The 7900 Induction Box is a convenien tly dimensioned 25x13x13cm cost effective solution to confine one guinea pig one rat or several mice It incorporates a sli ding lid and tubing connectors vaporizer input and scavenger output A larger size 7910 is also available dimensioned 44x22x 21cm for larger animals such as rabbits Dual Diverter Manifold with Humidifier All of the Ugo Basile Gas Anesthesia Systems come with a pre installed mounting bracket to fit the Dual Diverter Manifold as shown in the picture The anesthetic gas flow can be diverted toward 2 inde pendent devices i e an induction chamber and a breathing mask A simple and efficient hu midifier is included with the manifold It is especially re commended for long term anesthesia when dehydration may become an issue Multiple Delivery System The Multiple Delive ry accessory allows the connection of up to six devices to one anesthesia system for simultaneous op eration Each device for 2 3 4 5 or 6 animals has independent flow regulation F AIR Scavenger A solution to handling waste anesthetic gases when active evacuation systems are not availa ble activated charcoal canisters remove approx 50g of halogenated ane sthetic agents from the waste gas stream before being discarded UGO BASILE www ugobasile com
184. vai lable encompassing a Hot Cold Plate an auxiliary Hot Plate and an interconnecting corridor to per form the Temperature Preference Tests see figure 2 overleaf Main Features Operating Temperature 2 C to 66 C pre settable by function keys Two operating modes fixed or ramping temperature for dynamic experiments PC Interface USB Hot Plate For Mice Cold Plate Temperature Preference Tests Computer compatibility direct connection to a PC via the dedi cated software included as standard Data Portability via the USB Memory Key included in the stan dard package Print out by optional thermal MiniPrinter Ugo Basile more than 10 000 citations HOT COLD PLATE No 35100 Instrument Description The Instrument features e acabinet of original design incorporating the Hea ting Cooling Plate and a Command Display Module e aconvenient Plexiglas restrainer suitable to restrain either mice or rats The multifunction liquid crystal graphic display mo nitors the plate temperature in 0 1 C steps and shows the reaction time in 0 1 s increments on the graphic di splay the display also presents all available commands the operator sets the experiment configuration via the command keyboard located on the right of the display The plate temperature can be set by the operator in the range 2 66 C The extremes of this ample range can be reached provided the room temperature
185. vided to alter the colour of the box walls and floor Each animal box includes a kit with 3 striped walls 3 chessboard 3 grey walls and 3 plastic floors white black grey Isolation Cubicle The new design Isolation Cubicle 46000 590 includes adual visible and I R LED light a loudspeaker anoiseless fan all conveniently positioned inside the sound attenua ting cubicle Multiple cage set ups include an expan sion cubicle with its slave electronics on board SS E Preinstalled PC optional The Ugo Basile Fear Conditioning systems can be used with Windows based laptop or desktop PCs which can be purchased directly from Ugo Basile with software amp hardware pre installed tested and ready to use Ordering Information COMPLETE SYSTEMS with software and USB camera MOUSE RAT 46153 46152 Complete Single Cage FC System 46253 46252 Complete Two Cage FC System 46453 46452 Complete Four Cage FC System BASIC SYSTEMS without software camera MOUSE RAT 46103 46102 Basic Single Cage FC System 46203 46202 Basic Two Cage FC System 46403 46402 Basic Four Cage FC System Additional Animal Kits including Cage expansion cubicle amp electronics no camera are available 46102 002 Rat 46103 003 Mouse All components can be ordered separately Bibliography S Yusufisaq et alia Post Weaning Social Isolation im pairs observational fear conditioning Behav Brain Res 242 1 142 149 2013 A
186. x Dimensions 40x40x2 2 h cm board 26x15x25 h cm controller Weight 5 5Kg Shipping Weight 10Kg approx Packing 67x42x53cm Bibliography Method Paper J R Boissier et P Simon Dissociation de deux compo san tes dans le comportement d investigation de la souris Arch Int Pharmacodyn 147 No 3 4 1964 J R Boissier et P Simon L utilisation d une r action parti culi re de la souris M thode de la planche trous pour l tude des m dicaments psychotropes Th rapie XIX 571 589 1964 Papers Mentioning 6650 O D Can et alia Anti depressant like effect of vitexin in BALB c mice and evidence for the involvement of mono aminergic mechanisms Eur J Pharmacol 699 1 3 250 257 2013 M G Blake et alia Scopolamine prevents retrograde me mory interference between two different learning tasks Physiology amp Behavior 102 3 4 332 337 2011 P B Gomes et alia Anxiolytic like effect of the monoter pene 1 4 cineole in mice Pharmacology Biochemistry amp Behavior 96 287 293 2010 S W Zhu et alia Influence of environmental manipulation on exploratory behaviour in male BDNF knockout mice Behavioral Brain Res 197 339 346 2009 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 02 2013 36 MOTORY COORDINATION ACTIVITY GRIP STRENGTH TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com Rotati n g Wh ee S e E a
187. x37 d x16 h cm plus restrainer Animal Restrainer 20 diam x 25 h cm Weight 3 5Kg Shipping Weight 7 0Kg approx Packing 65x34x28cm 34 02 2013 ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS www ugobasile com Hole Board Cat No 6650 General The Hole Board 6650 has been conceived to study the innate exploratory behavior of the mouse con fronted with a new environment head plunging stereotype according to the classic method devi sed by Boissier Simon The normal mouse of either gender when confron ted with a new environment will explore holes in the substrate of its environment by poking its nose in and out of the hole a few times then moving on to the next hole The initial exploration activity of the animal and its variations brought about by psychotropic drugs are unmistakably assessed The nose poke frequency provides an indicator of exploratory behavior The test lasts few minutes and does not require any previous training conditioning of the animal Main Features Quick Test for Exploratory Behavior in Mice The classical MOTORY COORDINATION ACTIVITY GRIP STRENGTH Planche Trous Test by Boissier amp Simon The recording of the nose poking stereotype takes place automatically A few minute test is sufficient for most screening tests No previous training conditioning required Ugo Basile more than 10 000 citations Hole Board
188. xp Path Phar makol 195 171 1940 Papers which include mention to 7020 K Ogino et alia Anti inflammatory Effect of Arginase Inhibitor and Corticosteroid on Airway Allergic Re actions in a Dermatophogoides farinae induced NC Nga Mouse Model Inflammation 36 1 141 151 2013 SJS Flora et alia Interactive effect of arsenic and fluoride on cardio respiratory disorders in male rats possible role of reactive oxygen species BioMetals 24 4 615 628 2011 N R F Nascimento et alia 1 8 Cineole induces relaxa tion in rat and guinea pig airway smooth muscle J Pharmacy and Pharmacol 61 3 361 366 2009 A Floch et alia Characterization of NK1 and NK2 ta chykinin receptors in guinea pig and rat bronchopul monary and vascular systems Br J Pharmacol 111 3 759 768 1994 W A K Lau et alia Methoxyphenamine inhibits basal and histamine induced nasal congestion in anaesthe tized rats Br J Pharmacol 101 2 394 398 1990 C Broquet et alia Aminoacylates and Aminocarba mates of 2 substituted 4 hydroxymethyl 1 3 dioxo lans as Ammonium Salts A new Series of PAF Antago nists Eur J Med Chem 25 235 240 1990 UGO BASILE www ugobasile com sales ugobasile com TEL 39 0332744574 AG 02 2013 ugo basile TRANSFORMING IDEAS INTO INSTRUMENTS VENTILATORS and GAS ANESTHESIA www ugobasile com Gas Anesthesia Systems Cat No 21100 General The U
189. y dripping for a more precise water consumption evaluation Activity Detection The coordinate ambulatory activity and rearing of the rodent on test can be measured via the optional motion detector Cat No 41700 043 consisting of two facing arrays of emitters and receivers which record beam bre aks as the animal moves No 41800 1 2 3 Electronics amp Data Acquisition Each feeding and drinking cage comes with feeding and drinking scales and incorporates a preamplifier module Cat 41800 010 which directly connects to the PC USB port for computer processing The consumed food and liquid and the optional activity can be recorded directly into a computer at preplanned intervals The Cage Monitoring System CMS Software 51800 manages up to 8 cages The software acquires data and provides results related to partial and total food liquid consumption and to activity Please refer to the software manual for additional in formation Ordering Information BASIC METABOLIC CAGES 41700 002 Metabolic Cage for rats up to 150 grams 41700 003 Metabolic Cage for mice 41700 004 Metabolic Cage for rats 150 to 300 grams 41700 005 Metabolic Cage for rats over 300 grams METABOLIC CAGES WITH FOOD amp DRINK RECOR DING PROVISION 41800 Cage for rats up to 150 grams 41801 Cage for mice 41802 Cage for rats 150 to 300 grams 41803 Cage for rats over 300 grams Each cage is provided with E WP008 Mains Cable Europe or

New Model

Contents

Download Pdf Manuals

Related Search

Related Contents