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Liquid Handling Products Catalogue 2008

1. X 1 AC adaptor Euro 2 AC adaptor U S 3 AC adaptor U K 4 AC adaptor Jpn The specifications are type test specifications achieved under strictly controlled conditions ISO 8655 Due to Biohit s continuous R amp D specifications may change without prior notice Note Minimum volume in P mode is 500 ul The 100 ul is possible in d mode Liquid Handling Products S3IS sINB 31 BIOHIT Innovating for Health Direct charging feature allows s pipetting while charging m Clear LCD display keeps you RE er ee eer informed of the pipettor s i current task Tip ejector allows effortless snai tip ejection even on 12 channel models Volume range colour coding Dispensing head rotates for optimum pipetting convenience 8 and 12 channel pipettors are available Individual piston tip cone assemblies allow easy repair and maintenance Safe Cone Filters for dd s Durable tip cone models 10 ul ePET Multichannel Performance specifications and ordering details Increment Test Inacc Volume ul Volume Range ul pl Channels Cat No materials provide excellent chemical resistance Impr V Tips on pages 52 53 p Filters on page 56 ePET Electronic Multichannel Pipettors ePET multichannel pipettor family a Pipettor selection guide on page 76 Ergonomics on page 72 Safe Cone filters Standard
2. E 1 gm BRE ui i mem er FN The RS eLINE platform enables the integration of the instrument and the pipettor A flexible cable between the instrument and the pipettor provides both the power supply and the operational control via RS 232 communication The solution is based on the Biohit single and multichannel eLINE electronic pipettors For example Pentapharm GmbH in Germany has developed a whole blood Point of Care coagulation system the ROTEM System with the RS eLINE as a key component The system is designed to reduce the risk of transfusion errors in critical surgery such as liver transplant cardiac or vascular surgery orthopaedic or trauma surgery OEM Solutions The Start mLINE is a pipettor based on any mLINE model that is equipped with an on off switch and cable This can be used with coagulation analysers or any other instruments that require precise timing Solutions for leading edge companies Tailor made solutions are a speciality of Biohit Several leading edge companies have for years been implementing variations of Biohit electronic and mechanical pipettors into their systems Some of these internationally recognised companies have developed very specific applications with the R amp D team of Biohit to exploit their own market niche The customer base includes global market leaders such as Pentapharm picture 3M bioM rieux Johnson amp Johnson Group companies Liquid Ha
3. ISO 8655 is a new international standard for piston operated volumetric apparatus ISO 8655 defines among other things terms and definitions regarding piston operated pipettors and their testing requirements for test equipment and test conditions testing procedure and maximum permissible systematic and random errors for pipettors inaccuracy and imprecision Biohit follows ISO 8655 and takes its requirements into account in its research and development production quality assurance and after sales service The Good Laboratory Practice GLP principles were created by OECD www oecd org to internationally harmonize test methods and laboratory practices Today GLP compliance is one of the key indicators of high quality laboratory services According to the GLP Apparatus used in a study should be periodically inspected cleaned maintained and calibrated according to Standard Operating Procedures SOP Records of these activities should be maintained Calibration should where appropriate be traceable to national or international standards of measurement For more information see www biohit com 70 SIS SINE Liquid Handling Products FINAS Lie Finnish Accreditation Service hw K041 EN ISO IEC 17025 Innovating for Health A pioneer in ergonomic design Biohit Working with pipettors is much more than just pressing the thumb This is why ergonomics has been one of Biohit
4. Included recharging base keeps the XL ready for use Proline XL operation modes e Pipetting e Multiple Dispensing Proline XL e Sequential Dispensing e Manual Pipetting Excel in maxi volumes In addition to being a pipette controller for 1 to 25 ml serologi Proline XL Performance specifications cal pipettes the Biohit Proline XL can be used as an electronic Performance Inaccuracy Imprecision pipettor and dispenser with 5 and 10 ml disposable tips The Proline XL can be easily programmed for exact operations with 25 ml graduated pipette i P mode 25 ml 0 40 0 30 either of the buttons acting as a trigger to start the operation For P mode 2 ml 140 0 60 96 example the XL can be programmed to automatically dispense d mode 10x 25 ml 1 00 1 50 10 x 1 ml to fill the cell culture plate which saves time and i i Biohit 10 ml tip see page 45 eliminates the need for visual control of pipetting Moreover P mode 10 ml 0 50 96 0 15 96 P mode 1 ml 2 40 96 0 30 96 he results are always repr ible the results are always reproducible dimode Toe imi 1 00 96 1 30 96 Biohit 5 ml tip see page 45 Ergonomic design of the XL allows optimal working height even P mode smi 1 00 96 0 20 96 with 25 ml serological pipettes P mode 0 5 ml 4 20 0 60 d mode 10 x 0 5 ml 1 70 96 1 50 96 Proline XL offers Battery Min 500 full cycles Weight 260 g e Efficient worki
5. Testing of the pipettor prior to service and Precalibration Report Especially customers working to GMP recalibration to establish how well the pipettor has detailing the inaccuracy and been performing as found Same combination of imprecision of each volume data points as shown above range tested Calibration service portfolio listed above and offered by Biohit After Sales Service centres may differ country by country Please contact your local dealer for details Please note Test volumes 100 50 and 10 of the nominal volume are defined by ISO 8655 2002 standard and thus these volumes are also recommended by Biohit The frequency of the testing and calibration depends on e Accuracy requirements of the application e Frequency of use Number of operators using the pipettor e Nature of the liquid dispensed e Specifications established by the user Requirements from GLP or quality systems mLINE and Proline Plus Proline mechanical 64 lsiAf Liquid Handling Products Calibration amp Accredited Calibration Services Accredited Calibration Services Nowadays many laboratories are accredited and work to strict service and calibration activities Biohit is one of the few inter quality control guidelines and regulations For this reason the nationally accredited ISO 17025 pipettor calibration laborato calibration of laboratories instruments must be certified by an ries in the world We o
6. Program up to 12 aliquot volumes per aspiration A series of different volumes can be delivered in any desired order An extremely beneficial feature when performing dilution series Automatic Dispensing Ad Efficient automatic dispensing with user defined pace control This mode is similar to the multiple dispensing mode but has the additional benefit of the dispensing cycles being under automatic control at a user specified pace 0 1 9 9 seconds Multi Aspirating SA Manual method for washing microplate strips Select the volume and the number of aspirations until the series is completed then discard the full aspirated volume in a single step Post Delivery Mixing or Mixing User controlled mixing time The piston is automatically moved up and down to mix the liquid in the delivery vessel The mixing time is controlled by the start button The mixing function is available in the pipetting or diluting modes P dd EISE 7 Liquid Handling Products Innovating for Health Pipetting preparations e Use the tip specified by the manufacturer Ensure that the pipettor and tip have been tested according to ISO 8655 and the tip is seated correctly e Make sure pipettors have been correctly calibrated e Check the pipettor tip and liquid are all at the same temperature e When pipetting liquids with temperatures different to the ambient temperature do not pre rinse the tip Change the ti
7. J BIOHIT Innovating for Health Standard Tips Biohit Standard Tips are made of premium grade virgin polypropylene The tips are metal free and available in autoclavable 121 C 20 min 1 bar Single Tray boxes as certified RNase DNase and endotoxin free in space saving Refill System and in Bulk packages Electron beam pre sterilized tips in trays are also available Made in Finland Filter Tips Biohit Filter Tips are made of virgin poly propylene and feature filter PE barriers to prevent aerosol and liquid contamination This helps protect against the risk of cross contamination and reduces maintenance requirements of the pipettor Filter tips are tray packed electron beam pre sterilized and certified as RNase DNase and endo toxin free Best tip ever premium pipettor tips from Biohit Biohit offers you precision made pipettor tips for use with all Biohit and most other brand pipettors providing excellent reproducibility and accuracy All standard tips and trays are autoclavable You can purchase these natural polypropylene tips in single trays as non sterile or pre sterilized in refills and in bulk packaging And last but not the least Biohit tips are manufactured in a protected environment following Good Manufacturing Practices GMP 48 sIISISIN Liquid Handling Products Pipettor Tips amp Accessories Single Tray boxes for safer laboratory work The ecological
8. s main concerns in product development for over 15 years Thanks to the company s research and development Biohit is able to offer the most ergonomic and user friendly liquid handling products available today 72 Liquid Handling Products Liquid Handling Guide Follow the signs of the ergonomic pipettor Did you know that Good finger support Pipetting over 1 5 h day 300 h year exposes to RSI 1 i Light weight Ergonomic Repetitive Strain Injury Rep jury handle design e Lab professionals have twice as much WRULD Work Related Upper Limb Disorder as employees in general e 44 of lab professionals suffer from disorders caused by Light plunger pipetting movement Clear amp e Pressing the plunger button as well as ejecting tips with a easy to read displa conventional mechanical pipettor together require a force e up to 70 N 7 kg which corresponds to the force required to lift 2 house bricks or 7 litres of milk l l l Light tip loading amp ejection Optimal length Fast amp light volume adjustment mLINE and eLINE offer the lightest and most ergonomic pipetting operations on the market Biohit eLIME E nin Biohit eLINE Electronic Electronic dem B min Biohit mLINE Mechanical Biohit AM s B max Mecnan ae Electronie pipettors Ma Convention manufacturers pipettors pipettors Ma Emo Pipertors B 0 100 200 300 400
9. s0erranareoricienia emen i a l Thermal insulation of LI the internal components li ensures that the warmth of the hand does not affect the pipetting results during long pipetting series TZPC Safe Cone Filters to prevent contamination Optiload tip loading for easy tip loading and ejection as well as excellent tip sealing in multichannel models 8 and 12 channel pipettors available Proline Plus Multichannel Performance specifications and ordering details Cat No Channels Increment Testvolume _ Inacc Impr Safe cone filters ul ul Standard Plus 728120 8 0 01 10 1 50 1 00 A L 5 2 50 2 50 M 1 4 00 4 00 728130 8 0 10 100 0 70 0 25 721008 721018 C D 50 1 00 0 70 O V 10 3 00 1 50 728140 8 0 20 300 0 60 0 25 96 721007 721017 D Q 150 1 00 0 50 96 30 2 00 1 00 9o 728220 12 0 01 10 1 50 1 00 A L 5 2 50 2 50 M 1 4 00 4 00 728230 12 0 10 100 0 70 0 25 721008 721018 C D 10 100 pl 50 1 00 96 0 70 O V 10 3 00 9o 1 50 28240 12 0 20 300 0 60 0 25 96 721007 721017 D Q 30300 150 1 00 96 0 50 96 30 2 00 1 00 14 AOE Liquid Handling Products The specifications are type test specifications achieved under strictly controlled conditions ISO 8655 Due to Biohit s continuous R amp D specifications may change without prior notice Pipettors Colour coding on display corres
10. t 0 4 96 10 00 200 ul 400 ul 600 ul 800 ul 1000 ul 0 5 96 t 0 6 96 25 00 500 ul 1000 ul 1500 ul 2000 ul 2500 ul 0 3 96 t 0 2 96 50 00 1000 ul 2000 ul 3000 ul 4000 ul 5000 ul lt 0 2 lt 0 2 The data for tips 0 5 and 2 5 ml are based on a measurement carried out with a 100 ul pipette tip The performance specifications apply to the Biohit Mechanical Stepper and Biohit Dispenser Tips non sterile System Ordering Details Description 725700 Biohit Mechanical Stepper including adapter for 25 ml and 50 ml syringe tips 36 SIS SIN Liquid Handling Products Solutions for Special Applications Biohit Mechanical Stepper Biohit Dispenser Tips Biohit Dispenser Tips Features e Function according to positive displacement principle e Contamination free dispensing no aerosols are formed e Made of virgin polypropylene tip and polyethylene plunger e O different tip sizes from 0 1 to 50 ml e DNase RNase ATP and Pyrogen Endotoxin free e Pre sterilized tips are individually wrapped e Suitable for use together with eLINE Dispenser and Biohit Mechanical Stepper as well as most other mechanical steppers Biohit Dispenser Tip package Ordering details Volume ml Package Qty Unit Cat No Starter Kit Includes 100 792038 20 0 5 ml 20 1 0 ml 20 2 5 ml 20 5 0 ml 20 10 0 ml 0 1 Non sterile 100 792017 Pre sterilized
11. Convenient pipettor holder included ith h pipettor 8 and 12 channel 0 With each pipetto pipettors are available Dispensing head rotates for aussi optimum pipetting convenience Individual piston tip cone assemblies allow easy repair and maintenance Sequential tip ejection All models gt 10 ul offer e allows easy one hand tip ejection replaceable Safe Cone Filters to Pe prevent internal contamination and damage Vv Tips on pages 52 53 Tip cone design allows easy tip S Filisis cin pages loading from trays and visual seal verification i Pipettor selection guide on page 72 Ergonomics on page 81 Proline Multichannel Performance specifications and ordering details Cat No Channels Volume Increment Test Inacc Impr Safe Cone Filters Range ul ul Volume ul 96 96 Standard Plus 720210 8 channel 0 10 10 1 50 96 1 50 96 A L M 5 2 50 96 2 50 96 1 4 00 96 4 00 96 720220 8 channel 0 50 50 1 00 96 0 50 96 721014 C D O V 25 1 50 96 1 00 96 PQ 5 3 00 96 2 00 96 720240 8 channel 5 00 300 0 70 96 0 25 96 721014 D Q 150 1 00 96 0 50 96 50 1 50 96 0 80 96 720310 12 channel 0 10 10 1 50 96 1 50 96 A L M 5 2 50 96 2 50 96 1 4 00 96 4 00 96 720320 12 channel 0 50 50 1 00 96 0 50 96 721014 C D O V 25 1 50 96 1 00 96 PQ 5 3 00 2 00 720340 12 channel 5 00 300 0 70 96 0 25 96 721014 D Q 150 1 00 0 50 50 1 50 0 80
12. V 2004 Poorly selected tips can cause major error to pipetting accuracy Int Labmate 29 2 55 56 e Mannonen S Syrj K 2000 Safety in Pipetting International Labmate 25 1 39 e Mannonen S Tiusanen T Suovaniemi O 2000 Major Sources of Error of Air Displacement Pipettors Lab Asia 7 2 38 39 e Kolari M Mannonen S Takala T Saris P Suovaniemi O Salkinoja Salonen M S 1999 The Effect of Filters on Aseptic Pipetting Lifetime of Mechanical and Electronic Pipettors and Carryover during Pipetting Letters in Applied Microbiology 29 123 129 Service amp Maintenance e Mannonen S Riikonen S 2000 Accredited Calibration and Future Demands for Pipettors International Biotechnology Laboratory 18 2 48 49 For literature see also www biohit com 82 X0 Liquid Handling Products Brochures Liquid Handling Rotel a rea angle Diagnostics All publications can be downloaded at www biohit com Liquid Handling Products S f siNR 83 BIOHIT Innovating for Health Made in Finland About Biohit Biohit was founded 20 years ago in 1988 The background of the company however stretches back to the 1970s when Professor Osmo Suovaniemi M D Ph D founder of Labsystems 1971 Eflab 1978 and Biohit 1988 together with his team developed and commercialised the first air displacement adjustable single and multichannel pipettors that made liquid handl
13. e Rest intervals worrying about Repetitive Strain Injury e Bench layout amp lighting e Number of repeated pipetting series Liquid Handling Products 3 Olz AN 73 BIOHIT Innovating for Health Safety in pipetting Pipetting with air displacement pipettors is one of the most common laboratory tasks and includes a number of potential Biohit safety features include risks The risks can be divided into three defined areas e Ergonomic pipettor design for improved occupational Physical risk through stress ergonomics health 2 Situations where the user is at risk of contamination Accurate and precise results with the appropriate tools through handling of infectious or toxic agents Cleanliness through Safe Cone Filters certified tips 3 Situations where the sample or specimen is at risk through autoclavable pipettors and decontamination tools contamination from other samples or environmental Appropriate storage with a wide range of pipettors factors ande e High quality after sales services amp accredited calibration Cleanliness is safety protect your pipettor and your sample from contamination The user is often well protected by appropriate working benches seats clothing and shields but the pipettor is forgotten Modern air displacement pipettors with disposable tips enable fast and accurate pipetting but contamination of the pipettors may increase both the possibility of unreliable result
14. guanta ab Pipette service and calibration software for the professional laboratory quanta 70 Pipette service and calibration software for the professional engineer QuantaCal Quar Add Edit Pipettes V V y Personalised Information V y y RS232 Balance Support V y y Calibrate Pipettes J y y Add Edit Test Plans V V y Multiple Departments V y y Calibration Reports V y y Multiple Customer Entry Optional V V Booking In Dispatch System Optional V y Pipette Collection Requests Optional J y Service Module Optional V V Spare Part Management Optional J J Due Overdue Pipettes Report Optional J y Service Calibration Recall Optional V V Email System Optional Optional V Quality Control Optional Optional V Report Editor Optional Optional V Management Reporting Optional Optional V Demo Equipment Management Optional Optional V Quote Generator Optional Optional Optional Mettler Multichannel Support Optional Optional Optional Accredited Certificates ISO17025 Optional Optional Optional Multi language Output Optional Optional Optional Pipette Collection Request is a sub module of the Booking in Dispatch system The Booking Dispatch system has to be in place before installing Pipette Collection request Spare Parts Management is a sub module of the Service Module The Service Module has to be in place before installing Spare Parts Management Please
15. tip insertion principle e Volume range from 1 ul to 50 ml e 5 speeds for aspiration and dispensing e Charging indicator e Direct charging option enabling dispensing while charging e Compatibility with eLINE charging stand and carousel e Compatibility with other dispenser tip brands eLINE Dispenser operating modes e Multiple Dispensing d e Pipetting P e Diluting dd e Sequential Dispensing Sd e Automatic Multiple Dispensing Ad e Multi Aspirating SA e Custom mode CST GL select service intervals P lal F i n Sr select the desired tip range I SET returns default settings j eLINE Dispenser ordering details Cat No Item 73070X Biohit eLINE Dispenser 73098X Biohit eLINE Charging Stand with AC adaptor 73099X eLINE Charging Carousel for 4 pipettors with AC adaptor 731001 eLINE replacement battery New member of the eLINE family X 0 Without AC adaptor 1 With AC adaptor Euro 2 With AC adaptor U S 3 With AC adaptor U K 4 With AC adaptor Jpn 5 With AC adaptor Aus Biohit has several worldwide patents and patents pending for its products Liquid Handling Products s3I9 slNB 35 BIOHIT Innovating for Health Biohit Mechanical Stepper The Biohit Mechanical Stepper is an easy to use positive displacement dispenser which allows rapid multi dispensing of pre set volumes up to 48 times in succession without refilling T
16. 1 4 00 96 4 00 96 710310 12 channel 1 00 100 0 50 96 0 20 96 721014 C D O P 50 0 80 0 40 Q V 10 2 50 96 1 50 96 5 4 00 96 2 50 96 710320 12 channel 5 00 250 0 40 96 0 15 96 721014 D Q 125 0 60 96 0 20 96 25 1 50 96 1 00 96 710810 12 channel 10 0 1200 0 80 96 0 15 96 721006 721016 H T Z 600 1 00 0 20 96 120 3 00 96 1 20 96 50 8 00 96 1 50 96 28 SJIS SIE Liquid Handling Products The specifications are type test specifications achieved under strictly controlled conditions ISO 8655 Due to Biohit s continuous R amp D specifications may change without prior notice Note Proline electronic pipettor needs a charging stand for operation Pipettors E a f 1 Proline charging options e T Place Charging Stand e 4 Place Charging Carousel The Proline electronic pipettors can be charged with a 1 place charging stand or a 4 place charging carousel The compact design of the 4 place charging carousel is ideal for saving bench space in the laboratory and allows the pipettor to be rested between dispensing routines The 4 place rotating head provides easy access to the desired unit Proline operation modes DTI Petes Fe a e Pipetting Pipetting with mixing e Reverse Pipetting excl 1200 and 5000 models e Multiple Dispensing e Diluting excl multichannel 1200 model Diluting with mixing excl multichannel 1200 model Stands amp Accessories e Sequential Dispens
17. 1200 ul Packaging Single Tray Single Tray Single Tray Single Tray Single Tray Single Tray Single Tray Single Tray Single Tray Pre Sterilized Pre Sterilized Pre Sterilized Pre Sterilized Pre Sterilized Pre Sterilized Pre Sterilized Pre Sterilized Pre Sterilized Qty Unit 10 x 96 Tips 10 x 96 Tips 10 x 96 Tips 10 x 96 Tips 10 x 96 Tips 10 x 96 Tips 10 x 100 Tips 10 x 100 Tips 10 x 96 Tips Liquid Handling Products Olz AN 53 790011F 783201 790021F 790101F 790201F 783207 783206 783208 783222 New design New design New design Standard Tips Oo MechanicalPipettors 49 9 SS Cat No mLINE 725010 Special Tips BIOHIT Innovating for Health CID E ul 0 1 3 0 5 10 Single Channel 725020 725030 L 4 D 20 725050 10 100 725060 20 200 e e 725070 100 1000 e 725080 500 5000 Ly b 8 Channel 725120 y 725130 725090 1 10ml 0 5 10 5 100 725140 BO 300 2 Channel 725220 0 5 10 725230 5 100 725240 Proline Plus 728010 Adjustable Volume 775920 Single Channel 728030 728050 V 4 p0 300 0 1 3 0 5 10 D 20 10 100 728060
18. 20 200 728070 100 1000 728080 500 5000 728090 fl 10 ml n 728590 10ml f 0 5 10 728130 10 100 i 728140 12 Channel 728220 728230 p0 300 0 5 10 0 100 n 728240 Proline Plus 728515 Fixed Volume 728520 Single Channel 728530 728535 p5 p0 300 b 10 DO 728545 O 728550 100 e 728560 200 728565 250 728567 500 728570 1000 728575 P000 728580 b000 728590 Oml Proline 720005 VOTEI SAVIO aeg 20000 Single Channel 720080 2 20 y 4 720020 5 50 e 0 1 2 5 0 5 10 bi 720050 10 100 e 720070 g0 200 720060 100 1000 720110 1000 5000 W 8 Channel 720210 0 5 10 720220 5 50 s fy 720240 50 300 t 1 2 Channel 720310 0 5 10 720320 5 50 720340 Proline 722001 Fixed Volume 722004 10 e Single Channel 722010 pO 50 300 b af 722015 5 722020 50 i 722025 100 722030 POO 722035 P50 722040 500 e e e 722045 1000 e e e 722050 2000 e 722
19. 43 N i 12N t Compression spring mechanism Tension spring mechanism Liquid Handling Products 9 BIOHIT Innovating for Health Easy maintenance and calibration The mLINE can be easily calibrated using the elegant calibration tool The tool also acts as a tube cap opener The mLINE should like any other pipettor be stored in an upright position There are several different stand options for mLINE e Handy holder that is included with each mLINE pipettor e Carousel stand for six pipettors Stylish linear stand that allows the pipettor to be placed on both sides of the stand Stands amp Accessories Cat No Item 725600 Carousel Stand for 6 pipettors 725610 Pipettor Holder for one pipettor 725620 Linear Stand 726203 Calibration tool Tube opener 10 AOE Liquid Handling Products The mLINE has been designed for easy cleaning and maintenance without any opening tool Only 3 4 parts need Pipettors Get started with mLINE Starter Kit Biohit mLINE Starter Kit offers an opportunity to test and get started with mLINE You can choose between two Starter Kits with three single channel mLINE pipettors Both kits also include colour coded tip racks for every pipettor and many useful accessories such as pipettor holder colour coding caps and a calibration tool which also acts as a tube opener All this is packaged into the durable
20. 5 100 Special Tips 71032XET 25 250 71081XET 50 1200 E Proline XL poa 71090X 0 1 25 ml ee Ry vidi Plus 71093X 1 100 ml e e gt Extended inaccuracy and imprecision of the pipettes with pre sterilized A tips Liquid Handling Products 2410 55 Innovating for Health A unique innovation preventing contamination Meet the Safe Cone Filters a unique safety innovation introduced by Biohit They offer an added advantage in preventing contamination of both the pipettor and the sample thus prolonging the service life of the pipettor Biohit Safe Cone Filters act as an alternative barrier to provide added protection because the filter prevents liquids from entering the internal mechanism of the pipettor Other safety improving products are the Biohit Proline Biocontrol Decontamination solution and pipettor stands Cleanliness is safety as we say in Biohit 56 JI9 SIN Liquid Handling Products Pipettor Tips amp Accessories Biohit Safe Cone Filters an alternative to filter tips Biohit Safe Cone Filters The interval of changing the filter These unique and replaceable filters act as a final barrier depends completely on the appli to prevent any fluids and liquid vapours from reaching the cation and the sample However internal co
21. Biohit Making no compromise on quality in product development raw materials manufacturing processes and after sales services The highly skilled innovative and experienced personnel and strict quality control according to international standards have attributed to the proven track record of Furthermore the low lifetime cost of the products warranty periods and environmentally friendly products allow for high return on investment Offering high quality after sales Vr O services which enable customers ica FINAS to meet tightening quality control requirements and help extend the life time of their liquid handling devices The service concept includes preventive maintenance and repair services standard and accredited calibration and training services provided through the extensive subsidiary and distributor network and the global customer service network of OEM and private label customers of Biohit ISO 9001 ISO 13485 ISO 14001 ISO 17025 www biohit com s110 Liquid Handling Products Pipettors Innovating for Health Made in Finland Effortless accuracy meet the mLINE family 6 Biohit s most advanced mechanical pipettor family the mLINE offers a unique combination of novel amp patented features for manual pipetting Excellent performance smooth ergonomics and perfect safety makes the mLINE It is comfortable to use hour after hour day after day without the ri
22. Electronic ePET Proline Plus 721008 Standard 50 725130 720080 720020 730340 730440 Q 2 51 mm Filters 725230 722010 722015 730040 PE 725050 722020 721007 Standard 50 725060 720050 720070 730060 730360 93 15 mm Filters 725140 722025 722030 730460 PE 725240 721006 Standard 50 725070 720060 722035 730080 730100 710100 710020 71002XET 5 33 mm Filters 722040 722045 730390 730490 710040 710500 71004XET PE 710800 710810 71050XET 71080XET 71081XET 721005 Standard 50 725080 720110 722050 6 73 mm Filters 722055 PE 721014 Standard 50 725030 720120 720130 710410 710420 71021XET 1 83 mm Filters 720220 720240 710210 710220 71022XET PP 720320 720340 710310 710320 71031XET 71032XET 721018 Plus 50 725130 720080 720020 730340 730440 2 51 mm Filters 725230 722010 722015 730040 PE 725050 722020 721017 Plus 50 725060 720050 720070 730060 730360 Q 3 15 mm Filters 725140 722025 722030 730460 PE 725240 721016 Plus 50 725070 720060 722035 730080 730100 710100 710020 71002XET Q 5 33 mm Filters 722040 722045 730390 730490 710040 710500 71004XET PE 710800 710810 71050XET 71080XET 71081XET 721015 Plus 50 725080 720110 722050 6 73 mm Filters 722055 PE PP polypropylene PE polyethylene Liquid Handling Products J sINR 57 BIOHIT Innovating for Health Biohit Proline Biocontrol decontamin
23. Proline Single Channel Performance specifications and ordering details Cat No Channels Volume Increment Test Inacc Impr Safe Cone Filters Range ul ul Volume ul 96 96 Standard Plus 710520 1 channel des t 0 10 10 0 90 96 0 50 96 A L M 02 10 pl 5 1 00 0 80 96 cond 1 2 50 96 1 80 96 0 2 12 00 96 10 00 96 710010 1 channel 1 00 100 0 40 96 0 15 96 C O V 50 0 70 0 30 10 2 00 1 00 5 2 50 1 80 710030 1 channel 5 00 250 0 40 0 15 96 C D Q 125 0 60 0 20 25 2 00 1 00 10 2 00 1 00 710100 1 channel 5 00 500 0 40 0 15 96 721006 721016 EG R 250 0 70 96 0 20 96 50 1 50 96 0 80 96 10 9 00 96 2 00 96 710020 1 channel 10 0 1000 0 60 96 0 15 96 721006 721016 E G S 500 0 80 0 20 96 100 2 00 96 0 60 96 50 2 00 96 1 00 96 710040 1 channel 5 00 1200 0 40 96 0 15 96 721006 721016 H T Z 600 0 70 0 20 120 2 00 0 60 50 2 00 1 00 710500 1 channel 50 0 5000 0 50 0 15 96 721006 721016 J 2500 0 80 96 0 25 96 500 0 80 96 0 60 96 The specifications are type test specifications achieved under strictly controlled conditions ISO 8655 Due to Biohit s continuous R amp D specifications may change without prior notice Note Minimum volume in P mode is 500 ul The 100 ul is possible in d mode Note Proline electronic pipettor needs a charging stand for operation Liquid Handling Products J siNN 27 BIOHIT Innovati
24. Refill System The Single Tray tip boxes are a must for demanding laboratory The Refill System of Biohit is environmentally friendly with a completely work The rigid and strong polypropylene boxes and trays are recyclable packaging The tip trays are easily transferred from a space fully autoclavable The tray holds 96 highest grade non wettable saving Tower or Refill Pack to the Single Tray tip boxes The Refill System virgin polypropylene tips in an 8 x 12 microplate format range covers the five most popular standard tip sizes The flip top boxes can be opened and closed with a single hand The colour coding of the tip trays allows immediate tip volume recognition Non sterile and pre sterilized standard Bulk Tips the economic option tips are available in single trays as certified RNase DNase and ae The most economic alternative is to buy Bulk endotoxin free as well as metal free Tips that are available in boxes with 100 400 or 1000 standard tips depending on tip size see ordering details However no ah Autoclaving instructions on page 81 Biohit tips and boxes are made of recyclable material compromises are made regarding the quality Tips trays amp boxes polypropylene PP r and the bulk tips undergo the same rigid Filters in filter tips polyethylene PE quality control as other Biohit tips Instructions on how to use the Refill Tower for 10 300 and 350 ul tips e Remove the empty tray from Liftup t
25. The specifications are type test specifications achieved under strictly controlled conditions ISO 8655 Due to Biohit s continuous R amp D specifications may change without prior notice 20 SJIS SIE Liquid Handling Products Pipettors Proline carousel stand for 5 pipettors Stands amp Accessories Cat No Item Fixed volume pipettor has white display to differentiate it from adjustable volume Proline pipettors 721000 Proline Carousel Stand for 5 mechanical pipettors 725620 Linear Stand V Tips on pages 52 53 721259 Proline Pipettor Holder for 1 pipettor Gi Filters on page 56 721234 MH Pipettor selection guide on page 72 Colour coding caps 6 pcs Ergonomics on page 81 Proline Single Channel FIXED Volume Performance specifications and ordering details Impr Safe Cone Filters Standard Plus Increment Test MEES Volume ul 96 96 Volume Range ul ul Cat No Channels 722001 1 channel gt 5 1 30 1 20 A C L M N 722004 1 channel a 10 0 80 0 80 A C L M N 722010 1 channel OX 20 060 0 50 721008 721018 C D N O 722015 1 channel ng 25 0 50 0 30 721008 721018 C D O 722020 1 channel EET 50 0 50 0 30 721008 721018 C D O 722025 1 channel ub 100 0 50 0 3096 721007 721017 C D O V P Q 722030 1 channel OX 200 04096 0 2096 721007 721017 C D P Q 72203
26. UV resistance e Excellent chemical resistance Small increments e Reduced pipetting and tip ejection force e Fully autoclavable V Tips on pages 52 53 eS Filters on page 56 e E Pipettor selection guide on page 76 Ergonomics on page 72 i Autoclaving instructions on page 81 Thermal insulation of the internal components ensures that the warmth of the hand does not affect the pipetting results during long pipetting series Robust design Good chemical amp UV resistance Fits the most commonly used lab tubes thanks to the slim tip ejector collar Safe Cone Filters to prevent contamination ee wo wie i n 0 Pipettors Volume setting with click stops E Suitable for both left and right handed users Colour coding on display corresponds to the colour coding of tip trays What s the difference Comparison of the pipetting forces needed See page 76 for selection guide Proline Plus Single channel Performance Specifications and Ordering Details Cat No Channels Volume range Increment Test Inacc Impr Safe Cone Filters ul ul volume ul 96 96 Standard Plus 728010 0 002 3 0 1 30 0 80 A L M TO 1 5 2 40 1 60 0 3 10 00 6 00 728020 0 01 10 1 00 0 60 A L M ETE 5 1 50 96 1 00 1 2 50 96 1 50 96 0 5 5 00 4 00 728030 0 02 20 0 90 0 40 721014 C N C 10 1 20 96 1 00 9
27. With AC adaptor Aus only eLINE stands Reagent Vessel arc The autoclavable and durable reagent vessel is made from polypropylene and is chemically resistant to all common reagents Cat No Qty Unit Capacity 783500 16 120 ml ae T ad K041 EM ISEC 17225 Beside pipetting laboratories must pay attention also to the quality and performance of the tools and equipment that are used in everyday work To ensure the continuous accuracy and precision of your liquid handling instruments we offer a wide range of high quality services such as quality control repair services preventive maintenance and calibration services And when doing it regularly you ll keep your pipettor in good operating condition and also help extend its life time 60 sJIS9ISIN Liquid Handling Products Service Providers Global network of trained distributors and certified service centers We provide preventive maintenance repair calibration and accredited calibration services through our global subsidiary and distributor network 1 Technically trained distributors All Biohit distributors have been carefully trained to maintain and calibrate liquid handling devices manufactured by Biohit 2 Biohit Certified Service Centers Biohit Certified Service Centers BCSC are highly qualified for technical service and calibration These service centres are authorised trained and regularly audited by Biohit to offer you the hi
28. and 5000 ul Proline el and all eLINEs Pm Available in 1 ch eLINE only SA Only on the 1200 ul Proline el and all eLINEs Charging stand for Proline el and eLINE 7 mLINE eLINE Proline mech Proline elec multichannels and ePET multichannels all models gt 10 ul Proline and ePET elec 1 ch models gt 250 ul 8 For storage not charging Liquid Handling Products Liquid Handling Guide hit Electronic Pit Pipetting modes for Biohit electronic pipettors Pipetting P D 09 ml E di o Automatic blow out Pipette a selected volume with automatic blow out with complete control of the piston movement Post delivery mixing may be used in conjunction with this mode Reverse Pipetting rP 4 T mi Optimises performance when pipetting viscous or biological fluids A selected volume plus an excess is aspirated into the tip After delivery the excess volume remains in the tip and is discarded Multiple Dispensing d ul Suite Quickly dispenses equal volumes Aspirate the total volume plus an excess and repetitively dispense equal volumes of liquid The volume and number of remaining aliquots are shown on the display Diluting dd Dilution ratios 1 2 to 1 50 Two different solutions separated by an air gap are aspirated and then dispensed together with automatic blow out This mode may be used also in conjunction with post delivery mixing Sequential Dispensing Sd
29. and is used over the whole volume range This including its mid volume 5 readings measured at imprecision of each volume is suitable for customers working to GMP its maximum middle and 10 of the maximum range tested or laboratories where a higher level of volume 5x100 5x50 and 5x10 confidence is required ISO 8655 Level Calibration 10 3 Pipettor is tested for inaccuracy imprecision and ISO 8655 Level Calibration 10 readings at each volume ensure a high linearity throughout its whole working range Report detailing the level of confidence This is suitable for including its mid volume 10 readings measured inaccuracy and imprecision customers working to GMP or laboratories at its maximum middle and 10 of the maximum of each volume range tested where a higher level of confidence is volume 10x100 10x50 and 10x10 required Accredited Calibration Pipettor is tested for inaccuracy imprecision Accredited Calibration Laboratories that are working with and linearity to determine the uncertainties of Certificate and uncertainty accredited laboratories or laboratories measurement for each volume calibrated Test budget in accordance with following ISO 17025 i e accredited volumes and data points are selected according to ISO 17025 This is the highest laboratories the customer requirements level of calibration available Additional Service Precalibration As Found Performance Test
30. available in single and multichannel models covering the volume range 0 2 5000 ul 26 IS SIN Liquid Handling Products Pipettors Induction charging provides corrosion free mounting a ps oo Simple keypad allows easy error free selection of liquid handling modes volumes and speeds Feather touch button activates all pipetting actions and reduces hand fatigue Bi Compound lever design and side position gives easy tip ejection Proline electronic for all pipetting E Computerized drive system with needs fast DC motor lets you work more Lightweight ergonomic design Ejector collar and tip cone ey ley miami mecienice sui ipettors Single point calibration can be removed for easy Ee 0000000000 e 5 speeds for aspiration and dispensing cleaning and maintenance e Wide volume range e Design that helps prevent Repetitive Strain Injury RSI e Option of single or 4 place carousel Requires charging stand charging stands either needed for operation e Comprehensive range of the most important liquid handling protocols v Tips on pages 52 53 Durable tip cone materials provide Filters on page 56 dE S excellent chemical resistance B Pipettor selection guide on page 76 j ja Models 250 ul offer replaceable Safe Cone Ergonomics on page 72 be Filters to help prevent contamination and damage
31. clean tip cone Tip ejector jammed or moves erratically e Tip cone and or ejector collar contaminated Clean with soft cloth and mild detergent Biohit Proline Biocontrol or 7096 ethanol Liquid Handling Products s3I9S slNB 81 BIOHIT Innovating for Health Literature Ergonomics e Vaughton R 2006 In case of emergency break glass Int Labmate 2006 e Mannonen S Nieminen P Kaasinen J Andersin K 2004 Multichannel pipetting how to SS choose the correct pipettor Int Biotech Lab 22 6 12 14 and Am Biotech Lab 22 13 12 14 e Mannonen S Nieminen P Kaasinen J Andersin K 2003 Raising the standard of mechanical ud pipetting Int Labmate 28 5 34 35 e Mannonen S Hintikka V and Syrj K 2002 Choosing the correct electronic pipettor Clin Lab Int 26 2 29 e Mannonen S Hintikka V and Syrj K 2002 The benefits of electronic pipetting How to choose MT _____ the correct pipettor Int Labmate 27 4 Guide 2002 2003 75 77 e Mannonen S Hintikka V Kaasinen J and Ekholm P 2002 Reduced tip ejection and pipetting forces prevent repetitive strain injuries RSI Biomed Prod 4 40 42 E MEE e Vaughton R Sep 1999 Taking the Strain Out of Pipetting International Biotechnology Laboratory ee e Hoskins D B Erickson J 1998 Laboratory Ergonomics the Wake Up Call A Case Study on How EA One Company Relieved Str
32. mandi a Pipetting Work mJ 0 100 200 300 400 500 Tip Ejectron Werle Comparison of pipetting work with electronic and mechanical pipettors Both the tip ejection force and the distance thumb has to travel to eject the tips have been measured gt y MLINE 4 eLINE i Mechanical Pipettors Electronic Pipettors effortless accuracy leader in performance amp ergonomics e Light weight for easy liquid handling e Fully electronic pipetting operations e The lightest pipetting force on the market e Multi function device a lot more pipetting modes than e Tip loading and ejection require only minimum force Optiload in a mechanical pipettor e Both left and right handed operation e Less stages means time savings especially in multi dispensing e Consistent results time after time twice as fast as a mechanical pipettor e 30 times lighter pipetting than with a mechanical pipettor For easy and ergonomic manual pipetting your first choice e Unique electronic one touch tip ejection should be mLINE as recommended by Health amp Safety Officers e Both left and right handed operation of leading pharmaceutical companies e User independent accuracy and precision Pay als aren ton t When you need to pipette and dispense liquids as comfortably Weight and design of the pipettor as possible your first choice should be eLINE This Award e Your seating position Winning pipettor enables you to focus on your work instead of
33. 00 96 5 3 50 96 1 50 73006X 1 channel 1 00 300 0 40 96 0 15 96 721007 721017 D Q 150 0 60 96 0 20 96 30 1 50 96 0 80 96 10 3 50 96 2 00 96 73008X 1 channel 5 00 1000 0 40 96 0 15 96 721006 721016 EG S 500 0 60 96 0 20 96 100 1 50 96 0 50 96 50 2 00 96 1 00 96 73010X 1 channel 10 0 5000 0 50 96 0 15 96 721006 721016 J 2500 0 80 96 0 20 96 500 1 00 96 0 40 96 X 0 Without AC adaptor 1 With AC adaptor Euro 2 With AC adaptor U S 3 With AC adaptor U K 4 With AC adaptor Jpn 5 With AC adaptor Aus Note Maximum volume 300 ul In the d mode the total displayed volume can not exceed 270 ul Note Minimum volume in P mode is 500 ul The 100 ul is possible in d mode The specifications are type test specifications achieved under strictly controlled conditions ISO 8655 Due to Biohit s continuous R amp D specifications may change without prior notice Liquid Handling Products s3I9S slNB 23 BIOHIT Innovating for Health Clear LCD display informs and instructs the user F during pipetting Easy to use keypad enables fast programming 8 oye ere ETRE RIA ey Volume range colour coding for easy pipettor and tip selection cece ences Dispensing head rotates to both directions without accidental disassembling for optimum RIDE He lt enienicnce Optiload tip loading and perfect tip sealing e Available in multich
34. 055 5000 e Extended inaccuracy and imprecision of the pipettes with pre sterilized A tips 54 I9 SIN Liquid Handling Products Pipettor Tips amp Accessories Electronic Pipettors eLINE Single Channel He D 8 Channel ss e EY 12 Channel Proline Single Channel cu d f 12 Channel i ng W eper Single Channel T7 Eora ie i ET 2 Channel Standard Tips Filter Tips OS SS EROE eS OS ua Cat No ul MINIOIPIQIRISIT 73002X 0 2 10 73004X 5 120 73006X 10 300 73008X 50 1000 73010X 73032X 100 5000 0 2 10 73034X 5 120 73036X 10 300 73039X 73042X 50 1200 73044X 73046X 73049X 710520 710010 5 100 710030 10 250 710100 10 500 710020 50 1000 710040 50 1200 710500 710200 100 5000 710210 710220 710800 710300 Q 2 10 710310 5 100 710320 45 250 710810 71052XET 50 1200 0 2 10 71001XET 5 100 71002XET 50 1000 71004XET 50 1200 71050XET 71020XET 100 5000 0 2 10 71021XET 5 100 71022XET 25 250 71080XET 71030XET 50 1200 0 2 10 71031XET
35. 100 792026 0 2 Non sterile 100 792018 Pre sterilized 100 792027 0 5 Non sterile 100 792019 Pre sterilized 100 792028 1 0 Non sterile 100 792020 Pre sterilized 100 792029 2 5 Non sterile 100 792021 Pre sterilized 100 792030 5 0 Non sterile 100 792022 Pre sterilized 100 792031 10 0 Non sterile 100 792023 Pre sterilized 100 792032 25 0 Non sterile 25 792024 j 50 0 Non sterile 25 792025 Adapter for 25 and 50 ml tips 3 pcs unit 792036 Po Includes 1 adapter unit eLINE Dispenser and Biohit Dispenser Tip system Performance specifications Tip volume Volume Increment Step size Test Inacc Number of ml min max ul max ul volume 96 dispensings ul ul min max 0 2 2 200 0 4 200 20 1 70 96 1 0096 1 100 200 1 50 96 0 20 96 0 5 5 500 1 500 50 0 80 96 0 8096 1 100 500 0 80 96 0 40 96 1 0 10 1000 2 1000 100 0 80 0 55 1 100 1000 0 80 0 20 96 2 5 25 2500 5 2500 250 0 50 96 0 5596 1 100 2500 0 50 96 0 20 96 5 0 50 5000 10 5000 500 0 80 96 0 5096 1 100 5000 0 80 96 0 15 96 10 0 100 10 000 20 10 000 1000 0 25 96 0 5096 1 100 10000 0 30 96 0 20 96 25 0 500 25 000 50 25 000 2500 0 50 96 1 0096 1 50 25000 0 50 96 0 15 96 50 0 1000 50 000 100 50 000 5000 0 40 96 0 8096 1 50 50000 0 40 96 0 15 96 The performance specifications apply to the eLINE Dispenser and Biohit Dispenser Tip non sterile System Due to Biohit s continuous R amp D specificati
36. 5 1 channel x04 250 0 4096 0 20 721006 721016 EGRS 722040 1 channel 2 500p 500 0 30 0 20 721006 721016 EGRS 722045 1 channel 10001 1000 030 0 20 721006 721016 ES 722050 1 channel 2000p 2000 0 3096 0 15 721005 721015 J 722055 1 channel 5000p 5000 0 30 0 15 721005 721015 The specifications are type test specifications achieved under strictly controlled conditions ISO 8655 Due to Biohit s continuous R amp D specifications may change without prior notice Liquid Handling Products 5410 I 21 Innovating for Health LINE Leader in performance amp ergonomics eLINE When you need to pipette and dispense liquids as comfortably as possible your choice should be eLINE This honorary mentioned Pro Finnish Design 2001 electronic pipettor takes analytical performance and ergonomic innovation to totally new levels Its fully electronic operation including tip ejection gives you the chance to concentrate the work effort to where it s needed the most eLINE pipettors cover the full volume range of 0 2 to 5000 ul 22 IS SIN Liquid Handling Products Pipettors Direct charging option with AC adaptor with immediate pipetting possibility Easy to use keypad enables fast programming Eia Seg des Clear LCD display with all the information you need Electronic start button for all pipetting operations Attractive e ergonomic desi
37. 6 2 3 00 95 2 00 95 728050 0 10 100 0 80 0 15 95 721008 721018 C D O V 10 100 pt 50 1 00 0 40 10 2 00 1 00 728060 0 20 200 0 60 0 15 721007 721017 CD PQ 2020040 100 0 80 0 30 20 2 00 96 0 80 728070 1 00 1000 0 60 0 20 95 721006 721016 E G S 100 1000 pi 500 0 60 0 20 100 1 00 0 40 728080 10 0 5000 0 50 0 20 721005 721015 J 500 5000 pl 2500 0 60 0 30 500 2 00 0 60 728090 20 0 10000 0 60 0 20 721005 721015 U ELE 5000 1 20 96 0 30 2000 3 00 95 0 60 The specifications are type test specifications achieved under strictly controlled conditions ISO 8655 Due to Biohit s continuous R amp D specifications may change without prior notice Liquid Handling Products 34 0 z NE 13 BIOHIT Innovating for Health Optiload tip loading and perfect tip sealing All Proline Plus multichannel pipettors are equipped with unique spring loaded tip cones the Optiload mechanism that e Allows tips to be loaded with constant force e Enables even and safe tip sealing to the tip cones with minimum force e Makes tip ejection light and easy e Is an advantage in multichannel models where even tip sealing is essential Volume setting with click stops Suitable for both left and right handed users 777 Robust design Colour coding on display corresponds to the colour coding of tip Good chemical amp trays UV resista nce
38. 7 721017 D Q 150 0 70 0 30 30 2 00 1 00 73049X 12 channel 5 00 1200 0 50 0 20 721006 721016 H T Z 50 1200 pl 600 1 00 0 30 120 2 50 1 00 X 0 Without AC adaptor 1 With AC adaptor Euro 2 With AC adaptor U S 3 With AC adaptor U K 4 With AC adaptor Jpn 5 With AC adaptor Aus Note Maximum volume 300 ul In the d mode the total displayed colume can not exceed 270 ul The specifications are type test specifications achieved under strictly controlled conditions ISO 8655 Due to Biohit s continuous R amp D specifications may change without prior notice 24 IS SIN Liquid Handling Products Pipettors eLINE charging options eLINE operation modes e T Place Charging Stand Pipetting e 4 Place Charging Carousel e Reverse Pipetting e AC adaptor e Pipetting with Mixing e Pipetting with Cycle Counter The eLINE electronic pipettors can be nu e Manual Pipetting charged with a 1 place charging stand a 4 e Multiple Dispensing place charging carousel or a direct charging pf e Dilutin AC adaptor The variety of charging options M 3 a Diluting with Mixing has been designed for optimal utility and all mn e Sequential Dispensing charging options are delivered with the AC e Multi Aspirating adaptor of choice It is possible to continue e Automatic Multiple Dispensing pipetting while the eLINE is charged through 6memory places for yo
39. A L M 0 5 10 ul 5 2 50 96 2 50 96 1 4 00 96 4 00 96 725230 12 channel 0 10 100 0 70 0 25 721008 721018 C D 50 1 00 96 0 70 O V 10 3 00 1 50 96 725240 12 channel 0 20 300 0 60 0 25 721007 721017 D O 150 1 00 96 0 50 30 2 00 1 00 96 The specifications are type test specifications achieved under strictly controlled conditions ISO 8655 Due to Biohit s continuous R amp D specifications may change without prior notice s110 Liquid Handling Products Pipettors Optiload tip loading and perfect tip sealing All mLINE pipettors are equipped with unique spring loaded tip cones the Optiload mechanism that e Allows tips to be loaded with constant force Enables even and safe tip sealing to the tip cone s with minimum force e Makes tip ejection light and easy e Is an advantage in multichannel models in particular where even tip sealing is essential Unique protection with Safe Cone Filters To prevent contamination of the pipettor and the sample the mLINE pipettors fea ture replaceable Safe Cone Filters The unique Safe Cone Filter of mLINE means that the filters can be ejection easily and safely removed by pressing the plunger button Safe Cone Filters are availa ble for both single and mul tichannel models 10 ul O Filters on page 56 The qualities that really convinced me to switch to Biohit mLINE are its light weight lowest pipetting and tip ejection forces e
40. Biohit bag Biohit mLINE Starter Kit 1 Cat No 725651 Biohit mLINE Starter Kit 2 Cat No 725652 e mLINE 0 5 10 ul e Biohit Tip 0 2 10 ul Single Tray e mLINE 2 20 ul e Biohit Tip 0 5 300 ul Single Tray x 2 e mLINE 10 100 ul Biohit Tip 0 5 300 ul Single Tray e mLINE 20 200 ul Biohit Tip 10 1000 ul Single Tray e mLINE 100 1000 ul Biohit Tip 10 1000 ul Single Tray e mLINE 100 1000 ul e Calibration Tool Tube Opener e Pipettor Holder x 3 e Calibration Tool Tube Opener e Pipettor Holder x 3 e mLINE Article e Colour Coding Caps mLINE Article Colour Coding Caps e mLINE Brochure Biohit Bag e mLINE Brochure Biohit Bag Biohit Liquid Handling Catalogue Biohit Pen Biohit Liquid Handling Catalogue e Biohit Pen Liquid Handling Products 3410 I 11 Innovating for Health Proline Plus Made in Finland Durable and dependable Proline Plus In the new Proline Plus pipettor Biohit has combined the basic functionalities of the traditional Proline mechanical with new state of the art pipettor design and technology Particular emphasis has been put on safety ergonomics and efficiency in pipetting as well as on the high quality of the device Proline Plus pipettors cover the full volume range of 0 1 pl 10ml in both adjustable and fixed volume models 12 AOE Liquid Handling Products Plus Is More Proline Plus the classic Biohit Proline reborn e Robust design e Good
41. DAOSO i rete s ROHR NOn C dida OO Oe Proline Plus Starter Kit Biohit Proline Plus Starter Kit offers an opportunity to test and get of the kits include many useful accessories such as a pipettor started with Proline Plus You can choose between four Starter X holder and a calibration tool which also acts as a tube opener Kits with two or three single channel Proline Plus pipettors All as well as literature Biohit Proline Plus Starter Kit 1 Cat No 728650 Biohit Proline Plus Starter Kit 2 Cat No 728651 e Proline Plus 0 1 3 ul e 2 single tray tip boxes e Proline Plus 0 5 10 ul 3 single tray tip boxes e Proline Plus 0 5 10 ul e Calibration Tool Tube Opener e Proline Plus 10 100 ul e Calibration Tool Tube Opener e Pipettor Holder x 2 e Literature e Proline Plus 100 1000 ul e Literature Pipettor Holder x 3 Biohit Proline Plus Starter Kit 4 Cat No 728653 Biohit Proline Plus Starter Kit 3 Cat No 728652 e Proline Plus 2 20 ul 3 single tray tip boxes Proline Plus 500 5000 ul e 2 bulk tip boxes e Proline Plus 20 200 ul Calibration Tool Tube Opener Proline Plus 1000 10 000 ul e Calibration Tool Tube Opener e Proline Plus 100 1000 ul Literature e Pipettor Holder x 2 e Literature Pipettor Holder x 3 Liquid Handling Products s3410 i 17 Innovating for Health Proline The original Biohit mechanical pipettor Proline More than 15 years in the
42. E and a stepper motor driven pipettor were tested for linearity in the d mode The measurement was done 5 times The DC motor driven Biohit electronic pipettor allows linear movement i e precise dispensing The tested stepper motor pipettor generated a linear movement error which is equal to over 1 5 ul This even exceeds the minimum adjustable increment of the pipettors In the d mode where even dosing is important this kind of an error is significant Stepper motor driven electronic pipettor 0 02 Measuring points 0 08 DC motor driven Biohit 0 06 E eLINE electronic pipettor 0 04 a O 4 H 0 02 0 I 1 IL Pale Gall 41 oil 61 TL 81 91 101 LoL 0 02 Measuring points 20 x 50 ul linearity measurement in d mode Precision Precision is an agreement between replicate measurements Precision has no numerical value it is quantified by imprecision High precision i e small imprecision means very little variation between repeated measurements on the same sample To achieve it a precision instrument is required but also good laboratory practice must be followed Not precise Not accurate Accurate Not precise Consistent results time after time with Biohit mechanical mLINE pipettors Performance test of Biohit mLINE violet line and a conventional pipettor blue line Pipettors were tested over a 5 hour period with sets of 5 repeat weighings of 500 microlitres 180 ti
43. Health Colour coding caps Thumb activated filter ejection i 1 Light plunger RHET button action Ergonomic finger support and ID tag for personal identification gt Clear and easy to read display with big numbers and small increments Locking mechanism preventing accidental 1 volume changes during Rotating dispensing head for pipetting optimal pipetting convenience All models gt 10 ul offer replaceable Safe Cone Filters and unique filter ejection to prevent internal contamination and damage Individual piston tip cone assemblies for easy F fe 4 maintenance WAS Optiload tip loading i mechanism for perfect tip sealing and light tip ejection V Tips on pages 52 53 Filters on page 56 e Pipettor selection guide on page 76 Ergonomics on page 72 am Autoclaving instructions on page 81 mLINE Multichannel Performance specifications and ordering details Cat No Channels Volume Increment Test Inacc Impr Safe Cone Filters Tip ID Range ul ul Volume ul 96 96 Standard Plus 725120 8 channel 0 01 10 1 50 1 00 A L M 0 5 10 ul 5 2 50 2 50 1 4 00 96 4 00 96 725130 8 channel 0 10 100 0 70 0 25 721008 721018 C D 50 1 00 96 0 70 O V 10 3 00 1 50 96 725140 8 channel 0 20 300 0 60 0 25 721007 721017 D Q 150 1 00 96 0 50 30 2 00 1 00 96 725220 12 channel 0 01 10 1 50 96 1 00 96
44. Innovating for Health Liquid Handling Products Catalogue 2008 BIOHIT Innovating for Health The hummingbird The sensitive and precise qualities of the hummingbird symbolise Biohit s product groups of liquid handling diagnostic products and analysis systems Biohit s liquid handling products based on the company s innovations and technologies are characterised by versatility flexibility power speed light weight quality robustness and well engineered design ergonomics accuracy and precision as well as safety in delicate operations 2 s110 Liquid Handling Products Biohit Liquid Handling Products Catalogue Contents Liquid handling products for safe accurate and ergonomic laboratory applications 4 Pipettors 5 Mechanical Pipettors mLINE Single amp Multichannel Pipettors 6 Proline Plus Single amp Multichannel Pipettors 12 Eat Proline Plus Single Channel Fixed Volume Pipettors 15 Pew Proline Single amp Multichannel Pipettors 18 Proline Single Channel Fixed Volume Pipettors 21 Electronic Pipettors eLINE Single amp Multichannel Pipettors 22 Proline Single amp Multichannel Pipettors 26 ePET Single amp Multichannel Pipettors 30 Solutions for Special Applications 33 eLINE Dispenser 34 Mechanical Stepper 36 Dispenser Tips 37 Proline XL Pipetting Controller 38 Midi Plus amp Midi Pro Pipetting Controllers 40 Biofiller 41 Prospenser Bottle Top Dispenser 42 Biotrate Digita
45. Pipette Doctor Service Center If such a service does not exist in your area please contact your Biohit distributor for further actions Preventive Service Calibratie Service Repair Serv Accrediteg Service Performance Testing B IM SIS EC Part Servig Prosucet Through Biohit After Sales Services you get High quality maintenance repair and calibration services for all Biohit pipettors Good operating condition and extended life time of the pipettors thanks to scheduled preventive maintenance programs and calibration services Cost savings with full spare part service with original spare parts for Biohit pipettors Time savings through convenient and cost efficient service contracts on site services and fast turnaround times Detailed documentation on services performed Liquid Handling Products 3410 I 61 BIOHIT Innovating for Health Biohit Preventive Maintenance and Repair Services Liquid handling devices such as pipettors are precision instruments that comprise a great variety of mechanical and electronic parts These parts are naturally subject to wear and damage over time for example e The piston surface can deteriorate wear or corrode over time e Tip cones are subject to chemical corrosion and wear especially in the tip sealing area e Batteries of electronic pipettors do not last forever and must be replaced regularly All these problems can be overcome by carrying out regula
46. Plus 71020XET 8 channel 0 10 10 0 90 0 50 A LM 5 1 50 96 0 80 96 1 4 00 4 00 71021XET 8 channel 1 00 100 0 50 0 20 721014 x C D O 50 0 70 96 0 30 96 P Q V 10 2 50 1 50 5 4 00 2 50 71022XET 8 channel 5 00 250 0 40 0 15 721014 D Q 125 0 60 0 20 25 1 50 1 00 71080XET 8 channel 10 0 1200 0 50 96 0 15 96 721006 721016 H TZ 600 1 00 96 0 20 96 120 3 00 96 1 20 96 50 8 00 96 1 50 96 71030XET 12 channel 0 10 10 0 90 96 0 50 96 A L M 5 1 50 96 0 80 96 1 4 00 4 00 71031XET 12 channel 1 00 100 0 50 0 20 721014 C D O 50 0 80 0 40 P Q V 10 2 50 1 50 5 4 00 2 50 71032XET 12 channel 5 00 250 0 40 0 15 721014 D Q 125 0 60 0 20 25 1 50 1 00 71081XET 12 channel 10 0 1200 0 80 0 15 721006 721016 H T Z 600 1 00 0 20 120 3 00 1 20 50 8 00 1 50 X 1 AC adaptor Euro 2 AC adaptor U S 3 AC adaptor U K 4 AC adaptor Jpn 32 SIS SIN Liquid Handling Products The specifications are type test specifications achieved under strictly controlled conditions ISO 8655 Due to Biohit s continuous R amp D specifications may change without prior notice Solutions for Special Applications 2 gt gt C aaa 3 Made in Finland A single innovation makes all the difference eLINE Dispenser hands you the most convenient and ergonomic approach to multip
47. Stands The Proline Plus pipettor should be stored in an upright position There are several different stand options e Carousel stand for six pipettors Stylish linear stand that allows the pipettor to be placed on both sides of the stand e A handy holder that is available as an accessory 725600 Biohit Carousel Stand for 6 pipettors 725610 Biohit Pipettor Holder for one Proline Plus mLINE pipettor 725620 Linear Stand for all Biohit pipettors Prevent contamination with Safe Cone Filters Proline Plus features unique Safe Cone Filters that e Prevent fluids and liquid vapours from reaching the internal components of the pipettor e Help you prevent contamination of your pipettor and sample in your everyday work e Prolong the pipettor life time e Are replaceable e Can be removed by using convenient forceps e Are available forall models gt 10 ul Liquid Handling Products fd Basic calibration and maintenance made easy e Noopening tools are needed e Only 3 parts need to be cleaned piston tip cone and tip ejector collar e Calibration is easy with the tool included in the package e Should you wish to leave it to a professional Biohit offers complete maintenance repair and calibration services Pipettors p v 3 Vit pa 4 OOO oO oc eeeben CHCHDICHOUICHO Oo oc ee ee ee OOII LEZE s n QNONONCNONCNONCHC Ow LA AAA DNDIOIOIOR
48. aceable Safe Cone Filters and unique filter ejection to prevent internal contamination and damage What s the difference mLINE Proline Plus Proline Comparison of the pipetting forces needed See page 76 for the selection guide Performance specifications and ordering details Cat No Channels Volume Increment Test Inacc Impr Safe Cone Filters Range ul ul Volume ul CZ Standard Plus 725010 1 0 002 3 1 30 0 80 e A L M 1 5 2 40 1 60 0 3 10 00 6 00 725020 1 0 01 10 1 00 0 60 A L M 5 1 50 1 00 1 2 50 1 50 0 5 5 00 4 00 725030 1 0 02 20 0 90 0 40 721014 C N 10 1 20 96 1 00 96 2 3 00 2 00 725050 1 0 10 100 0 80 0 15 721008 721018 C D O V 50 1 00 0 40 10 2 00 1 00 725060 1 0 20 200 0 60 0 15 96 721007 721017 C D P Q 100 0 80 0 30 20 2 00 0 80 725070 1 1 00 1000 0 60 0 20 721006 721016 E GS 500 0 60 0 20 96 100 1 00 96 0 40 96 725080 1 10 0 5000 0 50 96 0 20 96 721005 721015 J 2500 0 60 96 0 30 96 500 2 00 96 0 60 96 725090 1 20 0 10000 0 60 96 0 20 96 721005 721015 U 5000 1 20 96 0 30 96 1000 3 00 96 0 60 96 The specifications are type test specifications achieved under strictly controlled conditions ISO 8655 Due to Biohit s continuous R amp D specifications may change without prior notice Liquid Handling Products 340 I 7 8 BIOHIT Innovating for
49. annel eLINE pipettors Individual piston tip cone assemblies allow easy repair and maintenance e Allows tip loading with an equal constant force to every channel e Tips are perfectly sealed to every individual tip cone e Is an advantage in multichannel models where tip sealing is essential Optiload tip loading Mc mechanism a v Tips on pages 52 53 As ZFC Replaceable Safe Cone I Filters on page 56 Filters help prevent contamination of the pipettor and samples Ergonomics on page 72 i Pipettor selection guide on page 76 is Autoclaving instructions on page 81 eLINE Multichannel Performance specifications and ordering details Cat No Channels Volume Increment Test Inacc Impr Safe Cone Filters Tip ID Range ul ul Volume ul 96 Standard Plus 73032X 8 channel 0 05 10 0 90 96 0 50 96 A L M 5 1 50 0 80 1 4 00 3 00 73034X 8 channel 0 50 120 0 50 0 20 721008 721018 C D V 60 0 70 0 30 12 2 00 1 50 73036X 8 channel 1 00 300 0 50 0 20 721007 721017 D Q 150 0 70 96 0 30 96 30 2 00 96 1 00 96 73039X 8 channel 5 00 1200 0 50 96 0 20 96 721006 721016 H 1 Z 600 1 00 0 30 120 2 50 1 00 73042X 12 channel 0 05 10 0 90 0 50 A L M 5 1 50 0 80 1 4 00 3 00 73044X 12 channel 0 50 120 0 50 0 20 721008 721018 C D V 60 0 70 0 30 12 2 00 1 50 73046X 12 channel 1 00 300 0 50 0 20 72100
50. asy to read display locking mechanism to prevent accidental volume changes and finally its compatibility to tips currently used at our company Richard P Roque Preclinical Development a Seattle based biotechnology company USA Unique spring mechanism for lighter pipetting The mLINE pipettor has a patented spring mechanism plunger technology resulting in the lowest pipetting forces on the market This together with light tip ejection force and ergonomic design of the handle reduces the risk of Repetitive Strain Injury RSI 80 70 60 50 40 30 JAD 0 Tt Lead iM Biohit Lightest Heaviest mLINE Conventional Conventional Pipettor Pipettor Ii Pipetting Force N Total Force for One Pipetting Cycle N E Tip Ejection Force N Pipetting and tip ejection force comparison of mLINE and other me chanical pipettors The mLINE provides significantly lighter pipetting and tip ejection forces than any other mechanical pipettor making the total force for one pipetting cycle pipetting to tip ejection the lightest on the market Ergonomics on page 72 Conventional pipettors use compression spring mechanism resulting in heavy pipetting force The tension spring mechanism used in Biohit mLINE pipettors makes pipetting force almost 4 times lighter Moreover thanks to the unique mechanism starting force is always constant regardless of the volume Conventional Biohit mLINE pipettors 17
51. at have a strict quality system such as ISO 9001 ISO 17025 GLP or any other quality system imposed by local legislation international standards or product service type e Laboratories that need to prove quality of their services or products to their customers e Laboratories following ISO 17025 ie accredited laboratories e Laboratories that are working with accredited laboratories but which are not necessarily accredited themselves 62 sJI9 SIN Liquid Handling Products Preventive Maintenance amp Repair Services Biohit Repair Service e Troubleshooting of the problem e Detailed service documentation service e Any customers with repair report and calibration report Biohit pipettors with e Disassembling the pipettor all parts are damaged components or inspected for damage and wear e Fully repaired and functional pipettor improper function and that need repair and calibration e Components are cleaned or replaced whenever e Original spare parts by qualified specialists necessary e Re greasing of the piston seal or o ring e Pressure leakage test e Calibration and performance testing according to the customer s requirements please see table on page 64 Biohit Maintenance by End User amp Full Spare Part Service e Product and technical service training is e Knowledge for service and test pipettors e Customers who want to provided to customers who want to service and in house service and
52. ation solution a safe simple solution for de LIT Doni Lia m ry instruments m X pettor become whether by incorrect pipetting techniques or by accident are in the tip cone area Daily safety maintenance Lightly spray the outside of the pipettor and wipe dry with a 3 clean cloth Clean surfaces such as incubators and benches with no noticeable contamination such as blood stains may be dampened using the Proline Biocontrol left on for 2 minutes and then wiped clean with an absorbent cloth Effective against e Viruses Hepatitis A B C D and E HIV Parvovirus Newcastle Disease e Bacteria Pseudomonas sp coli Staph aureus Proteus mirabilis Proteus vulgaris Streptococcus sp Bacillus sp Salmonellae Klebsiella sp Enterobacter sp Serratia sp Mycobacterium sp Listeria sp Legionella pneumophilia e Fungi A Niger Penicillium sp T Mentagrophytes Candida albicans Biohit Proline Biocontrol is e Non toxic and non irritating to humans and animals e Ready to use e Lethal to a broad spectrum of viruses bacteria and fungi e BS6471 Approved e Non corrosive to metals Non fuming e Odourless and non staining e Non mutagenic e Alcohol aldehyde phenol and chlorine free e Effective at removing odours Environmentally friendly biodegradable e Stable for long periods Cat No Pack Format Qty Unit 724004 5 litre Economic Large Container Biohit Pro
53. atteries AA 3x 1 2V 270 mAh NiCd 2 x 1 2V NiMH Charging batteries 14 hours for completely empty battery 14 hours for completely empty battery Battery service life from empty Approx 7 hours service life when fully charged 500 1000 cycles AC adaptor Output voltage 9 V DC Output 75 10 mA DC Filters Hydrophobic 0 45 uum Hydrophobic 0 45 um or 0 2 um Case material ASA PC ASA Nose cone material PVDF autoclavable ASA Pipette holder Silicone autoclavable Silicone autoclavable 40 sIIS9ISIN Liquid Handling Products Solutions for Special Applications Midi Plus amp Midi Pro Pipetting Controllers Biofiller Midi Plus amp Accessories Ordering details Qty Unit 71093X Midi Plus Pipetting Controller with 1 AC adaptor 712912 Replacement filter 0 45 um 5 autoclavable 712913 Replacement filter sterile 0 45 um 711015 Adapter set for 5 ml tip 1 711016 Adapter set for 10 ml tip 1 780300 Biohit tip 5 ml 100 780310 Biohit tip 10 ml 100 X 1 AC adaptor Euro 2 AC adaptor U S 3 AC adaptor U K 4 AC adaptor Jpn 1 Note Adapter set includes both the nose cone PVDF and the silicon adapter Biofiller Basic pipetting at its best Biofiller is a uniquely designed lightweight and easy to use pipette filler with an ultra squeezable bulb to provide smooth manual pipetting control in both aspirating and dispensing using 1 ml to 100 ml pipe
54. cal pipettor can be steam sterilized by autoclaving at 121 C 252 F 1 bar 15 p s i for 20 minutes The dispensing head of the multichannel pipettors must be unscrewed 360 counterclockwise before autoclaving e Remove the Safe Cone Filter if fitted e Put the pipettor into the sterilization bag and place it into the autoclave e After autoclaving the pipettor must be cooled down and left to dry overnight before use It is recommended to check the performance of the pipettor after every autoclaving and to grease the piston seal of the x L temperature of 121 C under 1 bar 15 p s i pipettor after every 10th autoclaving Tips and tip boxes e Place the bulk tips into the sterilization bag and the tip tray as such in the autoclave e Autoclave for 20 minutes at a e Cool down before use Troubleshooting guide Liquid Handling Guide eLINE electronic pipettor lower part The dispensing head tip ejector collar tip cone holder tip cone spring and piston of the single channel and multichannel models except for multichannel 1200ul can be autoclaved 121 C 1 bar for 20 minutes These parts can be autoclaved as one unit or separately as individual parts It is also possible to clean the parts and grease the piston prior to autoclaving e Remove the Safe Cone Filter if fitted e Put the dispensing head into the sterilization bag and place it into the autoclave After autoclaving the parts must be cooled dow
55. calibrate test their own pipettes in house pipettors in house schools e Original spare parts and universities hospitals e Biohit provides so called preventive with technical maintenance maintenance packages that include the most e Cost effective departments etc frequently used components for pipettor service e Easy with preventive maintenance e Customers who do not packages require traceable calibration e Your nearest Biohit distributor or Biohit of international measurement Certified Service Center also provides the full standards range of original Biohit spare parts ensuring fast delivery All spare parts are described and listed in instruction manuals and dedicated Technical Service Manuals Service portfolio listed above and offered by Biohit After Sales Service centres may differ country by country Please contact your local dealer for details For more information about Preventive Maintenance Repair and Calibration services please contact your local Biohit representative or go to www biohit com Note Before sending any instruments to technical service please ensure that they are free from all conta mination Please fill in decontamination certificate and advise our Service Centers of any hazardous materials which may have been used with your pipettor Liquid Handling Products s3I9 slNB 63 BIOHIT Innovating for Health Calibration Services The principles of Good Laboratory Practice GLP stat
56. e be traceable to national or international Standards of measurement GLP Good Laboratory Practice The suite of Quanta software Meets ISO 8655 DIN 12650 ISO 9000 ISO 17025 and GLP requirements Can be used with your current calibration protocols Connects to any balance supporting RS232 interface controls and collects calibration data automatically from the balance Converts automatically mass into volume by using temperature and barometric pressure Provides automatic calculations on inaccuracy and imprecision Produces calibration reports and optional reports automatically Includes a database of 1500 pre loaded test plans for all major manufacturers pipettes and liquid handling instruments Provides calibration specifications in accordance with manufacturers specifications ISO 8655 2002 maximum permissible errors or user defined specifications Allows you to service your pipettes via the software recording exactly what has been done to the pipette what has been fitted in the way of spares what has been the cost of maintenance etc Maintains a complete service and calibration history which can be accessed easily Provides full audit trail on service and calibration measures who what when and why Provides user assistance online www quantapro net user wizard and user manual Can be customized to your needs Liquid Handling Products sINR 67 BIOHIT Innovating for Health The suite of Q
57. e that to national or international standards of measurement laboratory equipment should be periodically inspected cleaned maintained and calibrated according to Standard Operating Biohit is one of the few accredited pipettor calibration laboratories Procedures SOP Records of these activities should be in the world today To help you fulfil the GLP or quality system maintained Calibration should where appropriate be traceable requirements such as ISO 9001 and ISO 17025 we offer you Basic Performance Testing 5 1 Basic checking of the inaccuracy and imprecision Performance Test Report This is a good basic performance check for the pipette 5 readings measured at mid volume for your pipettes and can be used for 5x50 laboratories working to GLP Basic Calibration 5 2 Pipettor is tested for inaccuracy and imprecision Calibration Report detailing This calibration can be used if the pipettor and also for linearity 5 readings measured at 10 the inaccuracy and is used over the whole volume range This of the maximum volume and maximum volume imprecision of each volume can be used for GLP and as an entry level 5x100 and 5x10 range tested calibration for GMP as well Enhanced Calibration 5 3 Pipettor is tested for inaccuracy imprecision and Calibration Report detailing This calibration can be used if the pipettor linearity throughout its whole working range the inaccuracy
58. echanical and electronic pipettors using P mode The a imprecision of ten subsequent results of volumes 10 25 50 100 200 T 2n sei E p T and 1000 ul was recorded and the results are detailed in pictures on the right Volume ml B Mechanica J Electronic Liquid Handling Products J sii f 29 Innovating for Health Made in Finland The compact and economical alternative ePET Biohit ePET electronic pipettors offer an easy and affordable access to electronic pipetting By using a direct charging system which requires no charging stand ePET is a very cost effective choice for electronic pipetting The ePET is available in single channel models covering the volume range of 0 2 to 5000 ul and multichannel models for 0 2 to 1200 ul 30 SJIS SIN Liquid Handling Products Pipettors Clear LCD display keepsyou jf moe Direct charging using AC adaptor informed of the pipettor s current task Simple keypad allows easy error free selection of liquid handling modes volumes and speeds Feather touch button activates all piston actions Compound lever design and side position provides easy tip Volume range colour coding ejection Computerized drive system with fast DC motor lets you work more efficiently than with mechanical pipettors i 7 ePET compact and economical Ejector collar and tip cone can be removed Pipetting for easy cleaning and maintenance e Pipetting
59. ed See page 76 for selection guide Proline Single Channel Performance specifications and ordering details Cat No Channels Volume Increment Test Inacc Impr Safe Cone Filters Range ul ul Volume ul Standard Plus 720005 1 T 0 05 2 5 2 50 2 00 A L 1 25 3 00 3 00 M 0 25 12 00 6 00 720000 1 Ta 0 10 10 1 00 0 80 A C 5 1 50 96 1 50 96 L M 1 2 50 1 50 N 720080 1 0 50 20 0 90 0 40 721008 721018 C N 10 1 20 1 00 O 2 3 00 2 00 720020 1 0 50 50 0 60 0 30 721008 721018 C D 25 0 90 0 60 O 5 2 00 2 00 720050 1 1 00 100 0 80 0 20 721007 721017 C D 50 1 00 96 0 40 96 O V 10 3 00 96 1 00 96 PQ 720070 1 1 00 200 0 60 0 20 96 721007 721017 C D 100 0 80 96 0 30 96 P Q 20 2 50 0 80 720060 1 5 00 1000 0 60 0 20 721006 721016 E G S 500 0 70 0 25 100 2 00 0 70 720110 1 50 0 5000 0 50 0 20 96 721005 721015 J 2500 0 60 96 0 30 96 1000 0 70 96 0 30 96 The specifications are type test specifications achieved under strictly controlled conditions ISO 8655 Due to Biohit s continuous R amp D specifications may change without prior notice Liquid Handling Products 340 I 19 BIOHIT Innovating for Health Volume setting by Simply turn the plunger click stops button for volume selection Tip ejector works with dispensing ee DERETTER in any position
60. ess and Strain on Its Employees Chemical Health and Safety January February m e David G Buckle P 1997 A Questionnaire Survey of the Ergonomic Problems Associated with Pipettes and Their Usage with Specific Reference to Work Related Upper Limb Disorders Applied Ergonomics Vol 28 No 4 257 262 e Hodgson E 1996 Work Related Upper Limb Disorders and the Laboratory World Directory of Environmental Testing Monitoring and Treatment e Fredriksson K 1995 Laboratory Work with Automatic Pipettes A Study on How Pipetting Affects copta sera ho the Thumb Ergonomics 38 5 1067 1073 ae e McGlothlin J D Hales T R 1995 NIOSH National Institute of Occupational Safety and Health Pit al text Health Hazard Evaluation Report e Bj rkst n M G Almby B Jansson E S 1994 Hand and Shoulder Ailments among Laboratory Technicians Using Modern Plunger Operated Pipettes Applied Ergonomics 25 88 94 Safety e Mannonen S Riikonen S 2006 In Vitro Diagnostics IVD compliance and what it means in practice Am Biotech Lab 24 8 18 20 e Mannonen S 2005 Use of a certified pipettor tip to protect samples Am Biotech Lab 23 8 23 24 e Mannonen S 2005 Protecting your sample Using a certified pipettor tip Int Biotech Lab 23 3 10 12 e Mannonen S 2005 Pipettor tip cone filters minimise the risk of contamination Labasia 12 4 24 25 and Int Labmate 30 5 15 16 e Mannonen S and Hintikka
61. ettor after over aspiration of blood sample Fig D Clean tip cone 74 SIS SINE Liquid Handling Products Consistent results Liquid Handling Guide One of the most common activities of laboratory workers is primary sample or reagent addition whilst performing a test Some laboratory workers perform thousands of tests daily There are a number of factors that influence the pipetting performance For example the quality of the products and tips human error pipetting techniques and strain as well as other factors such as environment temperature air pressure humidity type of sample and type of application The most difficult demand for accurate and precise pipetting results is the consistent handling and continual depression of the plunger on pipettors Accuracy It is possible to be very consistent but consistently wrong Inaccuracy is the numerical difference between the mean of a set of replicate measurements and the true value High accuracy i e small inaccuracy means very little difference between the mean sample and the true value Accuracy is achieved by careful calibration of a precise instrument Accurate Precise Precise Not accurate Ten times more precise dispensing with Biohit electronic pipettors unbeatable linearity When comparing the stepper motor technology and the DC motor technology for accuracy and precision the dispensing d mode is the best choice The DC motor driven Biohit eLIN
62. ffer you accredited calibration for both independent body that is competent and qualified to perform new and serviced Biohit pipettors Accredited Calibration Certificate ISO 17025 for new and serviced Biohit pipettors Accredited Calibration Certificate FINAS Accredited Calibration Certificate supplied Laboratories that are working ISO 17025 together with your with your new or serviced Biohit pipettor with accredited laboratories includes the Uncertainty Budget defining the or laboratories following new uncertainties for the measurement involved ISO 17025 i e accredited Serviced laboratories As a result you will know exactly what kind Biohit pipettors of uncertainty is due to the performance of Ask for an additional the pipettor and what is due for example to Accredited Calibration the uncertainty of the balance Certificate from your nearest dealer next time you order a new pipettor from Biohit Price varies depending on pipettor model Accredited calibration service for serviced pipettors is also available at Biohit UK UKAS and Biohit France COFRAC An Accredited Calibration Certificate means that e Measurements are traceable to national and international cofra oh standards e Calibration has been carried out to the highest standards La O e Agreed and specified methods and procedures have been se FINAS followed sje KO41 ENITSO IEC 17025 U K A S TheBiohit laboratory issuing the certif
63. ghest quality of service They have also been tested and approved to provide traceable calibration results by the Biohit accredited FINAS calibration laboratory The Biohit Certified Service Centers maintain standard operating procedures for technical service and calibration test equipment has been set up in accordance with ISO 8655 and the personnel have been carefully trained Please visit www biohit com for your nearest Biohit Certified Service Center METTO abc M ii sione im oro ques Mec Agr Biohit Pipette Doctor Service Biohit Pipette Doctor Service Centers have expertise to service and calibrate pipettes of all makes all models and all volumes Pipette Doctor is the ultimate level of pipettor service within Biohit s after sales services and in the world Pipette Doctors are high performance service centers that have deep technical knowledge and competence to service and calibrate more than 800 different pipettor models Pipette Doctor service is very practical if you have also other than Biohit pipettors in your laboratory Pipette Doctor professional can service and calibrate them all Advantages are as follows Professional one stop pipettor service for all makes and models No need to send pipettors to many different locations Easy simple and effortless service e Cost savings through a single service contract for all makes and models Please visit www pipettedoctor com for your closest
64. gn Volume range colour coding for eLINE leader in performance and ergonomics easy pipettor and tip selection Excellent accuracy and precision with the unique DC motor concept Ejector collar tip cone and piston can be e Fully electronic operations guarantee user independent it unscrewed for easy cleaning autoclaving results l and maintenance e Makes pipetting faster and easier e Built in error control for more reliable results e Easiest tip ejection ever with the unique electronic tip ejection e Ergonomic design that suits both left and right handed e You need only one pipettor instead of two one eLINE covers the volume ranges of two mechanical pipettors N Comprehensive range of liquid handling protocols 000000 75583 with easy programming 0 00000000000 UU Replaceable Safe Cone Filters help prevent contamination of the Vv Tips on pages 52 53 pipettor and samples 6 Filters on page 56 W Pipettor selection guide on page 76 e Ergonomics on page 72 au Autoclaving instructions on page 81 eLINE Single Channel Performance specifications and ordering details Cat No Channels Volume Increment Test Inacc Impr Safe Cone Filters Range ul ul Volume ul 96 96 Standard Plus 73002X 1 channel 0 05 10 0 90 0 40 A L M 0 2 10 yl 5 1 00 96 0 70 96 1 2 50 96 1 50 96 0 2 12 00 96 10 00 96 73004X 1 channel 0 50 120 0 40 96 0 15 96 721008 721018 C D V 60 0 60 96 0 20 96 12 2 00 96 1
65. hange during pipetting e Avoid leaving the pipettor on its side with liquid in the tip which might seep back into the mechanism Other cautions e Rack the pipettor when not in use see product pages for more information on pipettor stands Electronic pipettors should be returned to their charging stands Avoid dropping the pipettor or allowing contact with dirt or grease e Change the Safe Cone Filter regularly recommendation after 50 to 250 pipetting cycles and always in case of over aspiration e Never strike the tip cone against the tip tray when loading the tip as this can damage the pipettor LE Avoid exposing the unit to extreme temperature changes humidity and dust operating temperature from 15 C to 40 C Service the pipettor regurarly de Clean the pipettor thoroughly before sending to service Decontaminating the pipettor with Biohit Proline Biocontrol is a suitable procedure Notify the service personnel for what purpose the instrument has been used Postal services can refuse to deliver instruments used with hazardous materials Make sure that a qualified person services the pipettor Liquid Handling Products s3I9 sl 73 BIOHIT Innovating for Health Mechanical pipettors mLINE Proline Plus Pipettor decontamination procedure Electronic pipettors eLINE 1 Unscrew the tip ejector collar counterclockwise and remove it 1 Unscrew the tip ejector collar cou
66. he unit comes complete with an adapter for 25 ml and 50 ml tips Features include e Easy single handed operation Lightweight 105 g yet robust construction e Maintenance free design e Compatible with a wide range of dispenser tips e Ideal for dispensing aqueous and viscous liquids e Dispensing volumes from 1 ul to 5000 ul min volume with Biohit Dispenser Tips is 2 ul e Its ergonomic design and positioning of the dosage button in the upper part of the device allow single handed volume selection loading and dispensing e Choose quickly and effectively according to the requirements of your applications between the highest precision or maximum repetitions of your desired dosage volume e 48 dispensing steps at intervals of 1 second without the need to refill thus saving 90 96 of the working time required by the usual pipetting technique e Tested according to ISO 8655 1 Biohit Mechanical Stepper and Biohit Dispenser Tip system Performance specifications Tip volume ml Dosage volume Imprecision Inaccuracy Adjustment on 1 2 dispenser Number of steps 23 0 10 2 ul 4 ul 6 ul 8 pl 10 pl lt 1 6 lt 3 0 0 20 4 ul 8 ul 12 ul 16 ul 20 ul lt 1 3 lt 2 0 0 50 10 pl 20 ul 30 pl 40 pl 50 pl lt 0 5 t 0 8 96 1 00 20 ul 40 ul 60 ul 80 ul 100 ul 0 9 96 t 0 9 96 2 50 50 ul 100 ul 150 ul 200 ul 250 ul 0 4 96 t 0 8 96 5 00 100 ul 200 ul 300 ul 400 ul 500 ul 0 3 96 lt
67. he upper part of the e Take one single tray from e Put the single tray into the the tip box tower box the refill tower empty tip box Instructions on how to use the Refill Pack for 1000 and 1200 ul tips e Detach a Refill Pack Open the cover film from e Remove the empty tray from e Takethe tip tray from the the marked corner the tip box Refill Pack and put it into the empty tip box Liquid Handling Products 3410 LI 49 BIOHIT Innovating for Health Every pipettor needs the best tip In liquid handling the pipettor and the tip always form a system Biohit tips have been developed to perfectly match Biohit pipettors By developing and producing both pipettors and tips Biohit is able to offer the best possible compatibility and pipetting results For example the unique Optiload tip loading mechanism see picture of mLINE and eLINE pipettors allows tips to be loaded with constant force which in turn secures optimal tip sealing and minimum tip ejection force Rigorous quality control to ensure accurate pipetting results As the tip is an integral component of the pipetting system its shape material properties and fit have a considerable influence on pipetting accuracy Variation in any of these will cause errors in the volume pipetted The quality management system follows not only ISO 9001 but also ISO 13485 ISO standard for medical devices which enables Biohit to give CE IVD In Vitro Diag
68. ically competent and authorized calibration company Regularly checking the performance of your pipettes is vital to ensure the ongoing quality of your results End users may not know that they are dispensing inaccurate or imprecise volumes of liquid which in turn could lead to incorrect results The more frequently you test and calibrate your pipette the sooner you would detect these inaccuracies and imprecisions This will maintain the integrity of your laboratory data and reduce the likelihood of having to repeat your work More about different calibration levels on page 64 Quanta range of software Biohit provides anyone who needs to check and calibrate pipettes from end users to pipette service companies with a range of software to ensure the ongoing performance of their pipettes Quanta schedules pipette calibrations controls and captures data from balances automatically performs all required calculations and produces reports such calibration reports service reports overdue pipettors reports etc Quanta software is suitable for both single and multi channel pipettes of fixed and variable volume manual and automatic dispensers burettes dilutors and volumetric glassware Apparatus used in a study should be periodically inspected cleaned maintained and calibrated according to Standard Operating Procedures SOP Records of these activities should be maintained Calibration should where appropriat
69. icate has been ETALONNAGE E d by ind dent t assessed by independent experts 2 1513 BIOHIT UNCERTAINTY BUDGET BIOHIT Balance Sartorius MC5 serial 11305654 Pipettor Biohit Proline 50 200 ul serial AQ30836 50 ul Parameter Interval Distribution Standard Sensitivity uncertainty coefficient c u x water temperature 1 K rectangular delivering cubic device expansion coefficient 9 00E 05 K 1 rectangular 5 20E 05 K 1 1 00E 05 ni K 5 20 nl temperature 2K rectangular 1 15 K 4 5 nl K 5 20 nl standard uncertainty associated with the volume V20 9 nl measured with the gravimetric measuring system precision on the calibration 63 nl standard uncertainty of the calibration Liquid Handling Products 240 l 65 BIOHIT As aleading designer and manufacturer of liquid handling products Biohit recognises the need to provide anyone who needs to check and calibrate pipettes from end users to pipette service companies with a range of software to ensure the ongoing performance of their pipettes The Quanta range of software has been designed to offer a tailor made solution whatever your requirement for calibration and pipette service software 66 sJI9ISIN Liquid Handling Products Quanta Quality control in labs why you need to do it Instruments and equipment used within a laboratory need to be routinely tested validated and calibrated by laboratory personnel or an external techn
70. ifference between traditional calibration and accredited calibration is that an accredited calibration service can differentiate between uncertainties of the pipettor and uncertainties of the measuring process As a result an accredited calibration service is technically competent to release a calibration certificate where the uncertainties for the measurement involved are listed Thereby the customer knows exactly what uncertainty is due to the performance of the pipettor and what is due for example to the uncertainty of the balance used Accredited calibration means that a customer can have full confidence in the technical competence of the body that carries out the calibration according to international standards ISO 9001 is a documentation of an organization s quality management system and as such tells very little about its competence to provide accurate and reliable test data Nowadays ISO 9001 is a must However if quality management is to be measured to determine the technical competence for the performance of testing and calibration laboratory accreditation is also required Calibration and testing laboratories certification bodies and inspection bodies are accredited The technical competence of these notified bodies is assessed against the European EN 45000 and international ISO 17000 Standards and respective ISO IEC Guides ISO 17025 is defined as General Requirements for the Competence of Testing and Calibration Laboratories
71. ing only 1200 and 5000 models e Multi Aspirating only 1200 models 51000X Proline Charging Stand for one pipettor For pipetting modes please go to page 77 51160X Proline Charging Carousel for 4 pipettors 711002 Proline Replacement Battery X 1 AC adaptor Euro 2 AC adaptor U S 3 AC adaptor U K 4 AC adaptor Jpn User independent accuracy with Biohit electronic pipettors m Whilst experience and good pipetting practice are essential for 5 aE deu VOCE e Ie Ol ASCII reproducible results with mechanical pipettors the electronic c gt ipettors produce precise results independent of user experi fe i A Experts ence o gt D e m Proline like all other Biohit s electronic pipettors features the Ho rg patented DC motor concept which enables more precise and 1000 200 100 50 25 10 E Volume ml smooth piston movement compared to mechanical pipetting 3 gt Sr NE This means superior accuracy and precision in all pipetting O a actions Results are always reproducible even with small vol Moderate experience 7 O umes independent on experience as hand control is totally T Q eliminated EC Ft I I I I E 1000 200 100 50 25 10 2 Volume ml E QUA ME 3 i No experience Nine persons were divided into three groups according to their experi ence in pipetting Each person pipetted distilled water with the same gt il Biohit Proline m
72. ing both more convenient and safer than before These inventions included the first 8 and 12 channel adjustable pipettors that were designed to aid the liquid handling work in the vertical photometry based analysers such as the very first 96 well microplate reader the Titertek Multiskan invented and developed by Professor Suovaniemi and his company Labsystems Over the years Biohit s liquid handling devices have taken their place in laboratories worldwide as ergonomic safe and reliable solutions for all types of pipetting and dispensing Today Biohit s mission is to enhance the well being and quality of life of people by developing manufacturing and marketing liquid handling products and accessories as well as diagnostic test systems for use in research health care and industrial laboratories In addition to liquid handling products and accessories Biohit also develops manufactures and markets diagnostic test systems for the screening prevention and diagnosis of diseases of the gastrointestinal tract The company s diagnostic tests are combined with pipettors instruments based on vertical photometry technology and related software to provide comprehensive analysing systems for research and clinical diagnostics Biohit focuses on business areas in which it possesses a strong foundation in research technology innovations and patented products The company s products are designed and manufactured according to the requiremen
73. is the only pipettor in the market that offers electronic tip ejection This feature has been designed for both left and right handed operation Improved accuracy and precision The solenoid brake of the eLINE enables over 10 times more precise positioning of the piston compared to a stepper motor driven system This is a major advantage in multi dispensing mode where liquid column has to be cut sharply to have even doses This means superior accuracy and precision Built in error control for more reliable results Even the best pipettor may occasionally make errors Important is to be able to notice them Biohit electronic pipettors feature a built in error control The pipettor controls and monitors the piston movement in real time If an error occurs while pipetting the pipettor notifies the user thus allowing for more reliable results Liquid Handling Products O s f 25 Innovating for Health Proline The original electronic for all pipetting needs In 1991 Biohit introduced its first electronic pipettors Since then Biohit Proline electronic pipettors have offered effortless and rapid pipetting with high levels of accuracy and precision Some say that the Proline range offers complete solutions for all pipetting needs Yes we think that too Proline pipettors are ergonomically designed and the tip ejection is easily operated with four fingers to avoid strain and fatigue during pipetting Proline electronic is
74. itored by dedicated software All Biohit tip trays are individually and automatically wrapped in air tight plastic to rule out any danger of contamination Personnel in production and packaging are highly experienced trained and equipped with the appropriate specially designed protective clothing masks hair nets and gloves to diminish the contamination risks Automated tip manufacturing process from handling of raw material to packaging and storage Liquid Handling Products 3 O z BR 51 BIOHIT Innovating for Health Single Tray Biohit Standard Tips Tip ID Volume Range 0 1 10 ul 0 5 300 pil New design 10 1000 ul 71 5 mm New Refill Pack Wide Bore Tip 10 1000 ul 68 5 mm New Refill Pack 50 1200 ul 71 5 mm Extra Long Tip Z 50 1200 ul 100 5000 ul 150 mm Extra Long Tip K 0 5 10 ml 242 mm for XL and Midi Plus 161 mm 52 I9 SIN Liquid Handling Products Refill Pack Packaging Single Tray Single Tray Refill Tower Bulk in Box Single Tray Single Tray Refill Tower Bulk in Box Single Tray Single Tray Refill Tower Bulk in Box Single Tray Single Tray Refill Pack Bulk in Box Bulk in Box Single Tray Single Tray Bulk in Box Single Tray Single Tray Refill Pack Bulk in Box Single Tray Single Tray Single Tray Single Tray Bulk in Box Bulk in Carton Bulk in Box Bulk in Box Refill Tower Non Sterile Pre Sterilized Non Sterile N
75. l Burette 43 OEM Solutions 44 rLINE Robotic Dispensing Module 46 Pipettor Tips amp Accessories 47 Standard Tips Filter Tips amp Tip Packages 48 Tip Manufacture amp Quality Control 50 Tip Specifications 52 Pipettor Tip Compatibility Chart 54 Safe Cone Filters 56 Biohit Proline Biocontrol Decontamination Solution 58 Pipettor Stands Reagent Vessel 58 After Sales Services 59 Service Providers 60 Preventive Maintenance amp Repair Service 62 Calibration amp Accredited Calibration 64 Quanta Service amp Calibration Software 66 Terms and definitions 70 Liquid Handling Guide 71 Ergonomics 72 Safety in Pipetting 74 Accuracy amp Precision 75 Choosing The Right Pipettor 76 Pipetting Modes for Biohit Electronic Pipettors 77 Pipetting Preparations Pipetting Action amp Other Cautions 78 Pipettor Decontamination Procedure 80 Autoclaving Instructions Troubleshooting Guide 81 Literature 82 Brochures 83 About Biohit Contact Details 84 Liquid Handling Products 240 3 BIOHIT Innovating for Health Liquid handling products for safe accurate and ergonomic laboratory applications Founded in Finland in 1988 Biohit has established its position in the world market with its innovative high technology liquid handling products The company s liquid handling Made in Finland range is currently the widest in the world Biohit continuously develops its products and processes in order to meet and often exceed the demands of
76. le dispensing The automated liquid handling operation offers accurate and repetitive dispensing also with viscous infectuous and high vapour pressure liquids The unique TipGuide selects and displays the most suitable tip size which saves time and eliminates the possibility of an incorrect tip selection Additionally a smart feature included in the whole eLINE product range is the unique electronic tip ejection which reduces the risk of RSI Repetitive Strain Injury 34 EXO Liquid Handling Products Solutions for Special Applications eLINE Dispenser Save your time let the TipGuide make the tip choice for you No time consuming volume calculations e Just set the desired volume and number of dispensings the TipGuide selects and displays the suitable tip size Direct charging option with AC adaptor with immediate dispensing Clear LCD display with all ear ISplay WI possibility the information you need Easy to use keypad enables fast programming Electronic start button for all pipetting operations eLINE Dispenser offers e TipGuide automatic guide for correct tip selection Attractive nnm e Outstanding ergonomics dispensing with minimum force ergonomic e Unique electronic feather light tip ejection design re mE minimal effort e Comprehensive range of liquid handling protocols with mu easy programming e Contamination free dispensing with positive displacement easy A Ed e
77. line Biocontrol is contamination in the labora tory It is specifically designed for decontaminating laborato The components of the pi which most often contaminated 58 JIS SIN Liquid Handling Products Pipettor Stands When the pipettor is not in use it il pi 1 L should bestored in an upright position in order to avoid contamination from dirty benches Biohit offers stands for all of its pipettors The stylish Biohit Linear Stand is designed for all Biohit mechanical and electronic pipettors and especially for mLINE Proline Plus Proline mechanical and ePET electronic pipettors The stand is also compatible with a wide range of other manufacturers pipettors The compact Carousel stands are available in different models both for storage only and for charging 725600 Biohit Carousel Stand for 6 mechanical pipettors 725610 Biohit Pipettor Holder for one Proline Plus mLINE pipettor 721000 Carousel Stand for 5 Proline mechanical pipettors 725620 Linear Stand for all Biohit pipettor models 73098X eLINE Charging Stand for one pipettor 73099X eLINE Charging Carousel for 4 pipettors 51000X Proline Charging Stand for one pipettor 51160X Proline Charging Carousel for 4 pipettors 710999 ePET Stand for one pipettor X 1 With AC adaptor Euro 2 With AC adaptor U S 3 With AC adaptor U K 4 With AC adaptor Jpn 5
78. livery jet allows fast and safe dispensing even to narrow tubes Prospenser Performance specifications and ordering details Cat No Item Increment MaxVolume Inacc 90 Impr 96 723049 Prospenser 0 01 2 5 ml with 38 40 and 45 mm adaptors 723050 Prospenser 0 1 5 ml with 38 40 and 45 mm adaptors 723051 Prospenser 0 2 10 ml with 38 40 and 45 mm adaptors 723052 Prospenser 1 30 ml with 38 40 and 45 mm adaptors 723053 Prospenser 1 50 ml with 38 40 and 45mm adaptors 721998 Extendable delivery jet see picture Please note that the Prospenser is not supplied with a reservoir 42 1 OslB8 Liquid Handling Products Solutions for Special Applications Prospenser Bottle Top Dispenser Biotrate Digital Burette Continuous display of volume dispensed with zero reset feature for multiple titrations l Em Bubble free ee l dispensing 1 Anti drip tap Biotrate Digital Burettes 0 30 and 0 50 ml The streamlined Biotrate digital burette and dispenser delivers accurate precise and convenient bottle top titration as well as optimum operator safety e The head can be conveniently rotated 360 for operator safety and comfort See through barrel ensures bubble free titration e Automatic switch off without losing the previous titrated volume when left unattended e No dripping when in static mode Anew safety pedestal valve a
79. llows the Biotrate fluid path to be turned off manually to prevent accidental delivery Its right angled spout is also designed to enhance safety in use Simple user calibration and factory reset for ISO 9000 T and GLP requirements Visible borosilicate glass barrel protected with a transparent polypropylene sleeve allows inspection of liquid before dispensing Chemically resistant and autoclavable liquid pathway CE ITC e Robust outer casing does not move during the priming or dispensing sequences e PTFE plunger and borosilicate glass barrel allow dispensing of aqueous solutions and some aggressive liquids e Powered by a 3 6V lithium battery giving a minimum life of 60 000 three minute titrations Automatic low battery voltage is indicated on the large easy to read LCD window Biotrate Performance specifications and ordering details Increment Inacc 96 723054 Biotrate 0 30 ml with 33 38 and 45mm adaptors 0 01 ml 0 2 96 0 1 96 723055 Biotrate 0 50 ml with 33 38 and 45mm adaptors 0 01 ml 0 2 96 0 1 96 721998 Extendable delivery jet see picture page 42 Please note that Biotrate is not supplied with reservoir Liquid Handling Products s3I9 slNB 43 Innovating for Health Made in Finland Tailored solutions for customer specific systems Yes it is a true story Biohit is a leading provider of tailor made OEM Original Equipment Manufacture solutions to cust
80. mes The same trained operator was used As shown it is very hard to meet the specifications red line ISO 8655 2 with a force demanding pipettor after prolonged pipetting hours whereas the light action of mLINE allows the same reproducibility over the whole period Literature on www biohit com and page 82 Pipetting Time in Minutes 180 Biohit mLINE Conventional Pipettor ISO 8655 Limit Liquid Handling Products 1 O 1 75 Innovating for Health Choosing the right pipettor Mechanical Pipettor Selection Electronic Pipettor Selection Guide Guide P Pipetting x X x d Multiple x X x Dispensing dd Diluting x x X rP Reverse X X Pipetting Sd X x Sequenced Dispensing Pm Manual X Pipetting Ad Automated x Dispensing SA Multi X x Aspirating Custom X Programmability Post Delivery X X x Mixing Speed 9 speeds 9 speeds 9 speeds Selection Manual Tip X X Ejection Electronic Tip X Ejection Autoclavable x lower part AC DC Charging Included Optional Adapter Charging Stand X x Holds 1 pipettor Charging X X Carousel Holds 4 Available as accessories pipettors 1000 ul 1 channel model Linear stand x X Warranty 2 years 2 years 2 years CE IVD marked X X X Notes Except multichannel 1200 ul dd Available on all models exept the 1200 ul multichannel Proline rP Available on all models exept the 1200 and 5000 ul Proline el Sd Only on the 1200
81. mponents of the pipettor according to studies the filter is recommended to be changed daily after 50 to 250 pipettings and immediately in case of over aspi The ultimate pipettor protectors are available as Safe Cone Standard and Safe Cone Plus It is recommended to use the Standard filter for general applications and the Plus filter for ration more demanding applications such as radioactive work cell To ensure the safety of the user culture bacterial and virological work and molecular biology y Standard filters can also be used for this type of work but they LOIGSRs SNOU DE USRA TO ANONG touching the contaminated filters need to be changed more frequently 9 by hand In addition the tip cone should be cleaned regularly For more info see literature on www biohit com and page 82 J y 8000 m Filter 7000 B No filter 6000 5000 ca 4 4000 No of No Safe Cone E Pipettings Filter Filter 3000 50 x 2000 100 1000 0 OA 250 D m mU ms 500 db Number of pipettings DNA 50 ul plasmid DNA 120 ug ml contamination in pipettor barrel Pipettor contamination in pipettor barrel when pipetting liquid culture of bacteria Micrococcus Luteus Safe Cone Filters Biohit pipettor compatibility and ordering details Cat No Description Oty Unit mLINE Proline Mechanical eLINE Proline
82. n and left to dry before use It is recommended to check the performance of the pipettor after every autoclaving and to grease the piston seal of the pipettor after every 10th autoclaving Problem Cause Solution Pipettor performance outside given specs e Unsuitable tip e Test with original manufacturer s tip e Non standard test conditions or calibration altered e Perform test according to the ISO 8655 standard and recalibrate if necessary Pipettor has not been maintained regularly e Dirty Safe Cone Filter Perform routine user maintenance and retest e Change Safe Cone Filter e Pipettor is leaking e See instructions below Pipettor is leaking e Unsuitable tip Use original manufacturer s tip e Tip incorrectly attached e Attach tip firmly e Worn or dirty tip cone e Clean tip cone e Change tip cone Worn or dried piston sealing e Clean and re grease o ring e Change the o ring e Instrument damaged Send for Service Operating button jammed or moves erratically Liquid has penetrated tip cone and dried inside e Clean and grease the piston seal and the tip cone e Safe Cone filter has been contaminated e Change Safe Cone Filter Insufficiant amount of grease on a piston and seal e Grease accordingly Pipettor blocked aspirated volume too small Liquid penetrated tip cone and dried e Clean and regrease o ring and piston and
83. n Multilateral Agreements MLAs Terms amp Definitions Preventive maintenance means renewing or replacing critical parts of a device on a regular basis to prevent malfunctions In other words preventive maintenance is about maintaining equipment in good operating condition There is no point in waiting for the pipettor to fail It is important to understand the difference between calibration and performance testing Performance testing is often thought to be calibration which is not the case Performance testing is the verification procedure for the pipettor using a gravimetric photometric or other test method Performance test is carried out to check that the calibration of the pipettor is correct In other words the balance reading converted into volume should be in accordance with the selected volume in the display If the results are incorrect the pipettor will be calibrated and tested again According to ISO 8655 1 2002 calibration is a set of operations that establish the relationship between the dispensed volume and the corresponding nominal or selected volume of the pipettor In other words calibration is the adjustment of the pipettor to give the selected volume In practice the length of the piston movement is adjusted so that the balance reading is in accordance with the selected volume on the display Every pipetting operation is only as accurate as the calibration of the pipettor used The d
84. ndling Products 340 45 BIOHIT Innovating for Health Biohit rLINE The ultimate OEM Dispenser Module The unique rLINE Robotic Dispenser Module has been developed as an ideal front end liquid handling tool for robotic sample processing This technology platform combines numerous unique and innovative features like electronic tip ejection and Optiload tip pick up to improve high quality performance and functionality of sample processors and automated instrumentation The rLINE Robotic Dispenser Module is offered as OEM platform for tailored products ranging from 1 to 1000 ul as single channel and 1 to 1200 ul as 8 channel Additionally a 250 ul single channel version is available as off the shelf for evaluation and feasibility purposes Robotic 250 ul tips in robotic racks are also available off the shelf 46 1 OlslB8 Liquid Handling Products 1 amp i 3 d a oy Ss ho l o The rLINE platform features and options e Compact space saving design e Fast and easy installation e Zero cross contamination e Integrated electronic tip ejector e Versatile serial interface RS 232 amp RS 485 amp CANBUS e Low voltage low current consumption e Liquid level sensor e Micro volume dispensing options For more information on rLINE and other customer specific solutions please visit www biohit com or contact Biohit at info biohit com Pipettor Tips amp Accessories gt TU
85. ng for Health Clear LCD keeps you informed of the pipettor s current task Feather touch button activates all piston actions Tip ejector allows effortless tip ejection even in 12 channel models Computerized drive system with fast DC motor lets you work more efficiently than with mechanical pipettors Dispensing head rotates for optimum pipetting convenience Individual piston tip cone assemblies allow easy repair and maintenance Models 10 ul have replaceable Safe Cone Filters to help prevent contamination and damage V Tips on pages 52 53 RO eae Ress 8 and 1 2 channel Filters on page 56 pipettors are available i Pipettor selection guide on page 76 Ergonomics on page 72 Proline Multichannel Performance specifications and ordering details Cat No Channels Volume Increment Test Inacc Impr Safe Cone filters Range ul ul Volume ul 96 96 Standard Plus 710200 8 channel 0 10 10 0 90 96 0 50 96 A L M 5 1 50 96 0 80 96 1 4 00 96 4 00 96 710210 8 channel 1 00 100 0 50 96 0 20 96 721014 C D O P 50 0 70 0 30 96 Q V 10 2 50 96 1 50 96 5 4 00 96 2 50 96 710220 8 channel 5 00 250 0 40 96 0 15 96 721014 D Q 125 0 60 96 0 20 96 25 1 50 96 1 00 96 710800 8 channel 10 0 1200 0 50 96 0 15 96 721006 721016 H T Z 600 1 00 0 20 120 3 00 1 20 96 50 8 00 96 1 50 96 710300 12 channel 0 10 10 0 90 96 0 50 96 A L M 5 1 50 96 0 80 96
86. ng with The specifications are type test specifications achieved under strictly controlled conditions ISO 8655 Due to Biohit s continuous R amp D specifications may change without prior computerized drive system notice r manuall lai Proline XL Ordering details e Single pointcalibration l e Possibility to handle a full Sab Ne eat Sal volume range of 0 1 to 25 ml 71090X Proline XL 1 Improved precision and 712912 Replacement Filter autoclavable 0 45 um 5 accuracy l uM 712913 Replacement Filter sterile 0 45 um 1 e 5 speeds for aspiration and dispensing 780300 Biohit Tip 5 ml 100 e Easy access to bottles and tubes 780310 Biohit Tip 10 ml 100 X 1 AC adaptor Euro 2 AC adaptor U S 3 AC adaptor U K 4 AC adaptor Jpn Liquid Handling Products 3410 LI 39 BIOHIT Innovating for Health Midi Plus amp Midi Pro The Super Controllers Midi Plus and Midi Pro are rechargeable pipetting controllers that operate with rechargeable battery Both instruments are suitable for all types of pipettes in the range of 1 to 100 ml Midi Plus and Midi Pro fit the hand comfortably and are ideal for use within a laminar flow or microbiological safety cabinet Both models include a low battery indicator and both are CE marked Midi Plus Midi Pro Stepless speed Hydrophobic autoclavable control allows for filter prevents i amem the aspiration and over aspiration 0770707777777777 i dispen
87. nostics certification for both pipettors and pipettor tips Quality is not automatically guaranteed unless the quality control QC process of the manufacturer is strictly controlled All Biohit tips are fully traceable mould cavity identification markings are printed in each tip and tip boxes are lot numbered The quality control includes thorough in house testing and CE checks Each lot of the single tray products is also tested and certified as RNase DNase and endotoxin free EF al Biohit pipettor tips are Made in Finland e Made to match Biohit pipettors e Made of high quality pure virgin polypropylene Free from dust or particles Certified free from metals like cadmium e Matched with the pipettor tip cone for secure sealing and easy tip ejection e Highly resistant to chemicals e Highly thermally resistant e Autoclavable e Packed in easy to use fully recyclable and environmentally friendly ISO 14001 packages e CE IVD marked and covered by ISO 13485 Subject to tight quality control e Traceable Mould cavity identification markings in each tip and lot numbered tip packages 50 JISISIN Liquid Handling Products Clean room quality manufacturing The manufacturing process and the environment in which the pipettor tips are moulded and packaged are potential sources of contamination If tips are manufactured in an open environment they may not be contaminant free As the ti
88. nterclockwise and remove it 2 Unscrew the tip cone holder counterclockwise and carefully remove it with the tip cone Remove the Safe Cone Filter if fitted 3 Unscrew the piston counterclockwise from the pipettor 4 Place the tip ejector collar tip cone holder tip cone and tip cone cylinder into a beaker containing Biohit Proline Biocontrol and leave for at least 30 minutes 5 After performing the procedure described above remove the components from the beaker and rinse them with distilled water then dry preferably with warm air for at least an hour 6 Re grease the piston as described in the instruction manual Replace all components including new filter if fitted 2 Unscrew the tip cone holder counterclockwise and carefully remove the tip cone holder tip cone and spring Remove the Safe Cone Filter if fitted 4 Place the tip cone tip cone holder tip ejector collar piston and spring into a beaker containing Biohit Proline Biocontrol and leave for at least 30 minutes 5 After performing the procedure described above remove the components from the beaker and rinse them with distilled water then dry preferably with warm air for at least an hour 6 Re grease the piston as described in the instruction manual Replace all components including new filter if fitted 80 SIS SIN Liquid Handling Products MLINE amp Proline Plus mechanical pipettors The entire mLINE and Proline Plus mechani
89. omers who require a little more from their liquid handling devices Thanks to our know how inventiveness and experience we can take care of the whole process from engineering concept to dispatch Custom made only for you 44 10 lI Liquid Handling Products Solutions for Special Applications Biohit OEM Solutions Safe reliable and easy to use In many applications such as diagnostic test and analysis systems the accuracy of the results and reliability of the system are mission critical This requires a lot from all components of the system also the pipettor Biohit places a great emphasis on accuracy precision safety and user friendliness of its products Its application specific solutions have been carefully manufactured according to the requirements of international quality standards As a customer you can rest assured Biohit solutions allow you to improve not only the safety and reliability but also the ease of use of your system Custom made for your needs Biohit has developed different technologies that can be applied in custom made solutions These include both electronic and mechanical liquid handling pipettor platforms The Start mLINE eLINE Proline and the new rLINE robotic dispenser module families are easy to adapt platforms for your system For more specific needs Biohit offers tailored solutions based on any of its pipettors To learn more about Biohit s OEM solutions contact us at info biohit com
90. on Sterile Non Sterile Pre Sterilized Non Sterile Non Sterile Non Sterile Pre Sterilized Non Sterile Non Sterile Non Sterile Pre Sterilized Non Sterile Non Sterile Non Sterile Non Sterile Pre Sterilized Non Sterile Non Sterile Pre Sterilized Non Sterile Non Sterile Non Sterile Pre Sterilized Non Sterile Pre Sterilized Non Sterile Non Sterile Non Sterile Non Sterile Bulk Tips Qty Unit 10 x 96 Tips 10 x 96 Tips 10 x 96 Tips 1000 Tips 10 x 96 Tips 10 x 96 Tips 10 x 96 Tips 1000 Tips 10 x 96 Tips 10 x 96 Tips 10 x 96 Tips 1000 Tips 10 x 96 Tips 10 x 96 Tips 10 x 96 Tips 400 Tips 1000 Tips 10 x 96 Tips 10 x 96 Tips 1000 Tips 10 x 96 Tips 10 x 96 Tips 10 x 96 Tips 1000 Tips 10 x 96 Tips 10 x 96 Tips 50 Tips 50 Tips 100 Tips 1000 Tips 100 Tips 250 Tips 790010 790011 790012 781349 790300 790301 790302 780011 790350 790351 790352 780033 791000 791001 791002 780021 780016 791020 791021 780053 791200 791201 791202 780043 791210 791211 780304 780305 780300 780308 780310 780315 Pipettor Tips amp Accessories Em pty TI p Boxes for Refi System tips and trays are not included Item Tip Type Standard Tips Oty Unit Cat No Empty Tip Box for Refill System 10 300 350 ul 10 790910 Empty Tip Box for Refill System 1000 1200 ul 10 790920 Tip ID Volume Range 0 1 10 ul 0 1 10 ul 10 500 ul 50
91. ons may change without prior notice Liquid Handling Products J siNN 37 Innovating for Health p adi Wr Special solutions for higher performance Even when you handle liquids with bigger volumes you still can do it easily and lightweight As long as you do it with Biohit For maxi volume liquid handling Biohit offers you a wide range of pipetting controllers and fillers Biofiller is a lightweight and easy to use pipette filler Midi Plus Midi Pro and Proline XL are battery operated rechargeable pipetting controllers Prospenser Bottle Top Dispenser and Biotrate Digital Burette provide hassle free and accurate dispensing 38 JISISIN Liquid Handling Products Solutions for Special Applications Proline XL Pipetting Controller Adjustable head allows full rotation for optimum ergonomical pipetting Hydrophobic autoclavable filter 3 prevents over aspiration Changeable and autoclavable adapters allow use with most common serological pipette sizes up to 25 ml as well as 5 ml O Less risk of Repetitive Strain and 10 ml Biohit disposable tips Injury RSI due to unique ergonomic design that is especially suitable for working under laminar airflow cabinets Locking button keeps the adapter in place and allows d easy change of the included adapters IVD Simple keypad allows easy error free selection of liquid handling functions Two electronic start buttons for all operations
92. p after each pipetting Ensure that any fluid viscosity variations have been accounted for and the correct technique is employed i e reverse pipetting e Ifhandling infectious or radioactive agents make sure appropriate shielding and other precautions protect the operator For information on safety accessories see pages 56 58 e Use Safe Cone Filter in the tip cone when possible 78 SIS SINE Liquid Handling Products Liquid Handling Guide PN 1 e is oom rrr oom pem AAA m 1 f C a IAF TICTANY af ITAA im rif C Pa l Va l A 3 amp rm l o X 4 4 Al q 18 A CENNI 109 a ius t 8 S BR W WE OR uus uas hl Sl INVII RB Pipetting action e Hold the pipettor in a vertical position Tilting the pipettor at an angle causes a volume greater than the set volume of liquid to enter the tip e Pre rinse of tip is always recommended e When aspirating fluid the pipettor tip should normally be immersed to a depth of 2 3 mm e When using a mechanical pipettor operate piston with a smooth and consistent thumb action for repeated results without foaming or bubbles e Itis recommended to pipette against the inside wall of the receiving vessel Remove the tip by drawing it up against the inside wall e Ensure the pipettor blow out action is fully activated e Ensure the volume is still set at the required position Pipettor with volume locking mechanism is recommended to avoid accidental volume c
93. p is an integral component of the pipetting system its shape fit material properties and especially manufacturing processes have a considerable influence on the pipetting accuracy purity and the pipetting results The certified Biohit pipettor tips have been carefully manu factured in a protected environment in Finland To avoid contamination from human contact Biohit has automated the whole manufacturing process All Biohit tips are fully traceable from inspection of raw materials to monitoring the final product and testing each lot for contaminants after production Biohit s tip production consists of experienced personnel high capacity injection moulding technology and premium grade pure polypropylene PP Equally important are automated clean production conditions from the raw material to the final product To minimise contamination special particle filtration HEPA and positive pressure are applied to keep contaminants out of the manufacturing area The pure polypropylene plastic material is automatically fed from silos through vacuum loaders to moulding machines The moulding machines are located in closed environments with robots automatically loading the tips Pipettor Tips amp Accessories The automatic camera checks each 10 pl Biohit pipettor tip thus ensuring the quality control of every individual tip onto the tip trays and moving the loaded trays to packaging All machines and robots are constantly mon
94. ponds to the colour coding of tip trays A wide range of fixed volume models available The slim tip cone design fits also narrow laboratory tubes v Tips on pages 52 53 S Filters on page 56 E Pipettor selection guide on page 76 e Ergonomics on page 72 did Autoclaving instructions on page 81 Cat No Channels Volume Increment Test volume Inacc Impr Safe cone filters range ul ul 96 96 Standard Plus ul 728515 1 Sul 5 1 30 96 1 20 96 A L M 728520 1 To 10 0 80 96 0 80 96 A L M 728530 1 D 20 0 60 0 50 721014 C N 728535 1 ET 25 0 50 96 0 30 96 721008 721018 C O V 728545 1 Con 50 0 50 0 30 721008 721018 C O V 728550 1 100p 100 0 50 0 30 721008 721018 C D O V 728560 1 eT 200 0 40 0 20 721007 721017 C D P Q 728565 1 ETE 250 0 40 0 20 721006 721016 E G R S 728567 1 25004 500 0 30 0 20 721006 721016 E G R S 728570 1 1000 pl 1000 0 30 96 0 20 96 721006 721016 EG S 728575 1 2200041 gt 2000 0 30 0 15 721005 721015 J 728580 1 5000p 5000 0 30 0 15 721005 721015 J 728590 1 Comi B 10000 0 60 96 0 20 96 721005 721015 U The specifications are type test specifications achieved under strictly controlled conditions ISO 8655 Due to Biohit s continuous R amp D specifications may change without prior notice Liquid Handling Products BslIS slNB 15 Innovating for Health
95. r maintenance and calibration programs to ensure the functionality and performance inaccuracy and imprecision of the pipettor According to extensive experience and research by Biohit failure rates can be significantly reduced if a regular and scheduled preventive maintenance program is carried out on the pipettors In addition the pipettor life time can easily be extended through regular service and replacement of critical components Biohit offers scheduled Preventive Maintenance Programs for service and calibration Biohit Preventive Maintenance Program e Cleaning of the pipettor e Cleaning of the lower parts ejector collars piston seal o ring tip cone e Replacement of the critical parts so called Preventive Maintenance Packages if needed e Re greasing of the piston seal or o ring e Pressure leakage test e Calibration and performance testing according to the customer s requirements please see table on page 64 Detailed service documentation service report and calibration report e Improved pipettor reliability e Constant pipettor performance level inaccuracy and imprecision Fewer failures due to unexpected malfunctions of the pipettor e Decreased pipettor downtime as a result of preventive maintenance packages e Longer lasting pipettors Lower number of pipettors that fail pre calibration e Less waste of time and money on exception reports e Laboratories th
96. regulatory authorities Biohit s products are developed and manufactured in Finland according to the requirements of the ISO 9001 ISO 13485 and ISO 14001 quality and environment standards Biohit also offers accredited pipettor calibration according to ISO 17025 All environmental bodies and most important its customers products are CE IVD marked and supplied with individual QC certificates In the liquid handling business Biohit focuses on Improving ergonomics of pipettor design and pr usability to reduce the risk of work related si x Biohit Global market leaders such as 3M bioM rieux and Johnson amp Johnson Group companies have chosen Biohit to upper limb disorders such as RSI Repetitive supply tailored high quality liquid handling solutions with Strain Injury Biohit is the global market their systems leader in electronic pipettors which combine performance and ergonomics to provide accurate reproducible and Providing solutions that bring higher added safe pipetting in the most demanding liquid handling value to different customer segments through ergonomic and user friendly products cost applications efficient product features and service contracts Enhancing safety at work by protecting laboratory workers and the sample to obtain accurate and reliable results Biohit guarantees the precision and accuracy of its pipettors when the customer uses tips developed and manufactured by
97. rs world wide go to www biohit com RUSSIA Biohit OOO Saint Petersburg Vasiljevskij ostrov 6 ja linija d 57 199048 Saint Petersburg Russia Tel 7 812 327 5327 Fax 7 812 327 5323 main biohit ru Biohit O00 Moscow Petrovsko Razumovsky av 29 building 2 103287 Moscow Russia Tel 7 495 614 9550 Fax 7 495 613 5577 taras pravdoljubenko biohit ru CHINA Biohit Biotech Suzhou Co Ltd Room 501 Office Block Hotel Equatorial 65 Yan An Xi Lu Shanghai 200040 P R China Tel 86 21 6248 5589 Fax 86 21 6248 7786 info china biohit com Innovating for Health Notes 86 X0 lI Liquid Handling Products Liquid Handling Products 340 I 87 Biohit Finnish innovation design and manufacture for professionals www biohit com KO UYOI_ 8007 4 0769006t
98. s and health risks in laboratory work Organic and inorganic contamination can create problems for the scientist No matter whether the particles are viral bacterial ribonucleases or metal elements in the testing environment they may lead to erroneous results It is the reduction in the numbers of these particles and avoidance of cross contamination or accidental addition to the sample or the equipment being used that needs attention Corrosion of the pipettor piston is another threat The number of corroded pistons that are replaced at service centres every mE Fig A Biohit mLINE features a unique tip cone filter ejection day and pipettors with totally contaminated inner parts is mechanism surprisingly high see Figures A amp C Fig B The tip cone filter can be changed easily and safely with the use of forceps supplied with every Biohit pipettor Finally to ensure the safety the laboratory worker should also pay attention to the ergonomics at work pipettor and environment take care of the proper shielding and protection gloves clothes and follow good laboratory practice by pipetting slowly and carefully to minimise aerosol formation and foaming Literature on www biohit com and page 82 Fig A Badly corroded and contaminated piston assemblies taken from a commonly used pipettor Fig B Biohit pipettor tip cone used with Biohit Safe Cone Filter Fig C Tip cone taken from a commonly used brand of pip
99. sing speed to be adjusted easily and precisely to suit either large or small volume pipettes Optional adapters as accessory allowing the unit to be used also with the Biohit 5 ml and 10 ml pipettor tips oe ee REL Md oo Selection of high or low modes allowing u oy variable aspirate and Operating rere dispense speeds with Unique stand buttons i blowout HN suitable for x bench or wall Attached Support ui F PC NR mounting is Prevents pipette contamination Saves space Allows the unit to be rested on a table with pipette attached g 1 i supplied with E the unit Not available in units sold in the United States Midi Plus amp Midi Pro Selection guide Feature Midi Plus Midi Pro Pipette types Plastic or glass 1 100 ml Plastic or glass 1 100 ml Pasteur pipettes Pasteur pipettes 5 ml and 10 ml Biohit pipette tips Rechargeable during use X X Adjustable speed Stepless speed control High and low speed modes Gravity dispensing X X Stand Attached support Suitable for bench and wall mounting Optional adapters for 5 amp 10 ml pipette tips X Weight 207 g 180 g without stand Low battery indicator X X Autoclavable parts Nose cone pipette holder and filter Pipette holder Midi Plus amp Midi Pro Technical specifications Feature Midi Plus Midi Pro B
100. sk of strains RSI Enjoy your work With mLINE pipettors you can mLINE pipettors cover the full volume range of 0 1 ul to 10 ml s110 Liquid Handling Products Pipettors mLINE for easy and ergonomic pipetting e The lowest pipetting forces on the market e Consistent results even in long pipetting series Lightweight e Optiload tip loading for perfect tip sealing and effortless tip ejection e Good UV resistance Safe Cone Filters protect your pipettor and sample e Recommended by Health amp Safety Officers y Tips on pages 52 53 g Filters on page 56 e l Pipettor selection guide on page 76 e Ergonomics on page 72 ud Autoclaving instructions on page 81 mLINE Single Channel 5 colour coding caps 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 a 0 0 serene Thumb activated filter ejection page 9 Ergonomic finger support no need to squeeze the Thermal insulation of the internal pipette components to improve accuracy 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0000 Fast and light stepless volume setting with small increments Clear and easy to read display with big numbers Locking mechanism preventing accidential volume changes during pipetting 7 Volume range colour coding for easy selection of the right Biohit tip nr Easy cleaning and maintenance without any opening tool 0 0 0 0 0 0 0 0 0 00 0 0a coco o Improved tip fitting All models gt 10 ul offer repl
101. tion manual Liquid Handling Products 3410 I 41 BIOHIT Innovating for Health u Borosilicate glass barrel protected with a transparent polypropylene sleeve Easy to adjust calibration mechanism Jimi Easily removable PTFE i piston for cleaning and ien smooth action Fine adjustment for exact and reproducible dispensing Chemically resistant liquid pathway if CIL OM Precision valve mechanism ensures easy priming and minimum waste with no leakage back into the reservoir the Prospenser stays fully T primed all day Bubble free dispensing Prospenser Bottle Top Dispenser The easy to use Prospenser delivers trouble free and reliable dispensing of liquids including strong acids alkalis and solvents e All models are fitted with an anti drip safety valve a feature which guards against drips when the Prospenser is not in use e A fine adjustment mechanism allows for even greater reproducibility for repeat dispensing e Unlike other bottle top dispensers the Prospenser s glass barrel can be disassembled from the pedestal for thorough cleaning This also ensures that in the unlikely event of damage you can replace the glass barrel as a spare part rather than have to buy a new dispenser The head can be conveniently rotated 360 for operator safety and comfort Wide range of adapters are included to fit the most common bottle sizes Optional extendable de
102. top of the world of pipettors In that time Proline pipettors have become a synonym for high quality Working with Proline you will get many years of reliable service The Proline pipettors cover the volume range 0 1 ul to 5000 ul with 8 different adjustable single channel and 8 adjustable multichannel models Proline is also available in fixed volume single channel models 18 EX0 lI Liquid Handling Products Pipettors Finger support keeps the instrument in place with minimum user effort oe Volume setting by click stops Tip ejector allows convenient one handed operation Digital display clearly Ff reads volume setting Ejector collar and tip cone can be removed for easy Proline a good basic pipettor Barrer eer ete eT cleaning and maintenance e Designed for many different types of routine laboratory work e Lightweight design e Good accuracy and precision e Volume setting by click stops Durable tip cone materials provide Full documentation warranties and excellent chemical resistance certificates What s the difference Safe Cone Filters to prevent internal contamination and damage V Tips on pages 52 53 All models gt 10 ul offer replaceable Safe Cone Filters to prevent internal B Pipettor selection guide on page 76 contamination and damage O Filters on page 56 mLINE Proline Plus Proline rgonomics on page 72 j Comparison of the pipetting forces need
103. ts of the ISO 9001 ISO 13485 and ISO 14001 quality and environment standards Biohit also offers accredited pipettor calibration according to ISO 17025 Additionally all products are CE IVD marked Biohit has several worldwide patents and patents pending for its products Biohit has a network of 450 distributors including 7 subsidiaries in 70 countries Further information on Biohit is available atwww biohit com 84 SIS SIN Liquid Handling Products Biohit Anniversary Innovating Contact details HEADQUARTERS BIOHIT OYJ Laippatie 1 00880 Helsinki Finland Tel 358 9 773 861 Fax 358 9 773 86 200 E mail info biohit com www biohit com GERMANY Biohit Deutschland GmbH Raiffeisenstrasse 1 61191 Rosbach Germany Tel 49 6003 82 820 Fax 49 6003 828 222 info biohit de JAPAN Biohit Japan Co Ltd NB Building 6F 2 15 10 lwamoto cho Chiyoda ku Tokyo 101 0032 Japan Tel 81 3 5822 0021 Fax 81 3 5822 0022 sales biohit co jp U K Biohit Ltd Unit 1 Barton Hill Way Torquay Devon TQ2 8JG United Kingdom Tel 44 1803 315 900 Fax 44 1803 315 530 sales biohit co uk FRANCE Biohit SAS 2 Rue du Grand Chene 78830 Bonnelles France Tel 33 1 3088 4130 Fax 33 1 3088 4102 commercial france biohit com USA Biohit Inc 3535 Route 66 Bldg 4 P O Box 308 Neptune N J 07754 0308 U S A Tel 1 732 922 4900 Fax 1 732 922 0557 pipet biohit com For a list of distributo
104. ttes Simply squeeze the large silicone bulb and the thumb lever controls both the aspirating and dispensing modes with a button to blow out residual contents of pipette if required Biofiller offers e Comfortable and simple to use e Precise pipetting control e Robust and lightweight e Large capacity bulb e Compatible with blow out pipettes Simple thumb button operation e Uses integral 0 45 um replaceable membrane filter to ensure liquid is not accidentally drawn into the unit e Autoclavable silicone pipette holder Biofiller Ordering details Midi Pro amp Accessories Ordering details Cat No Item Qty Unit 71091X Midi Pro Pipetting Controller with 1 AC adaptor 721962 Replacement filter 0 45 um 5 721965 Replacement filter 0 2 um 5 721966 Replacement filter sterile 0 2 um 1 721963 Replacement silicone pipette holder 1 Qty Unit 723039 Biofiller Pipette Filler with integral 1 0 45 um filter 721963 Replacement silicone pipette holder 1 721962 Replacement filter 0 45 um 5 721965 Replacement filter 0 2 um 5 721966 Replacement filter sterile 0 2 um 1 X 1 Euro AC adaptor 2 U S AC adaptor 3 U K AC adaptor 4 Japan AC adaptor 5 Australian AC adaptor available only for MidiPro The Midi Pro is fitted with a 0 45um filter and supplied complete with charger two spare hydrophobic filters 1x 0 45um and 1x 0 2um bench stand and instruc
105. uanta software has been designed to offer a tailor made solution whatever your requirement for service and calibration software The software has been developed in a modular way enabling you to choose the options that you require to calibrate your pipettes Our standard tailored modules are as follows QuantaCal Our entry level software QuantaCal is designed primarily for the end user that simply needs to maintain a database of their pipettes to be able check them against the manufactures specification ISO8655 or end user specification and to produce a detailed calibration report that will satisfy general GLP GMP requirements QuantaLab Our midrange software QuantaLab is a unique menu based software system incorporating QuantaCal as its base module and seven additional options see table that enables you to control whole service and calibration process and is ideally suited to the smaller service company or organisation that tests and maintains their own pipettes in house QuantaPro The most comprehensive service and calibration software on the market Developed for the professional high output pipette service companies or large multi site end user accounts it can develop all aspects of the service process from receipt to dispatch Quanta Software Modules Modular structure Quanta offers you what you need not what you are given quanta Pipette calibration software for the professional laboratory
106. ur the AC adaptor The compact design of the MEME m favourite pipetting protocols 4 pipettor charging carousel is ideal for e O speeds for aspiration and saving bench space in the laboratory and dispensing allows the pipettor to be rested between dispensing routines with a tip attached The ama For pipetting modes please go to page 77 4 place rotating head provides easy access to the desired unit Note Not available in eLINE multichannel models Cat No Item eLINE is the perfect pipettor taking care 73098X eLINE Charging Stand for one pipettor with AC adaptor of both the work and the person using It 73099X eLINE Charging Carousel for 4 pipettors with AC adaptor Lisbeth Lemmetti Development Analyst Biomedicine 725620 near Stand Blood Centre at Sahlgrenska University Hospital Sweden 731001 eLINE Replacement Battery X 1 With AC adaptor Euro 2 With AC adaptor U S 3 With AC adaptor U K 4 With AC adaptor Jpn 5 With AC adaptor Aus Patented Biohit DC motor concept Unique one touch electronic tip ejection Tip ejection can be laborious The patented and unique Biohit concept includes and at worst a contributing the DC motor solenoid brake and error control factor to Repetitive Strain Injury RSI With the eLINE this is no longer the case as the unique electronic tip ejection system allows tip removal at the light touch of a button The eLINE
107. visit www quantapro net for further information on optional modules 68 X0 I Liquid Handling Products Ordering Details CAT NO ITEM WHAT SUITABLE FOR 770020 QuantaCal Basic module of QuantaCal End users and small service see table on page 68 companies who wish to simply check pipettes on a regular basis 760005 QuantaLab Basic module of QuantaLab End users and small mid size see table on page 68 service companies that need to have full control of service and calibration process 760002 QuantaPro Basic module of QuantaPro High output service companies see table on page 68 and demanding end users that require versatility from service and calibration software 770040 Validation package for Quanta Installation Operational and Anyone who needs to validate Software Performance Qualification calibration set up in accordance documents IO OQ and PQ with prevailing standards N A For upgrades optional modules and Upgrade your software to your related catalogue numbers please see requirements www quantapro net How to order e Please contact your local Biohit representative for ordering information or Log on to www quantapro net and complete a contact form which will be forwarded to your nearest Biohit representative or Log onto www quantapro net complete an online ordering form and purchase the software with a credit card Evalution Version Please download evaluation version from ww
108. w quantapro net or request a dvd from your Biohit representative Evaluation version allows for storing information on and calibrating 25 pipettes Recommended System Requirements e 2GHz Pentium P4 Processor e Windows 2000 XP Vista Vista 64 256Mb RAM e 100Mb Free Disk Space Online Support and Additional Information Please visit www quantapro net for technical support and further information Availability Q2 2008 Quanta software produces individual calibration reports on each pipettor tested Quanta software developed by a professional pipettor and service company is truly the most comprehensive pipette service and calibration package available today Quanta Liquid Handling Products 3 O z AN 69 BIOHIT Innovating for Health re Si a Pri LA an Fay I The accredited calibration laboratory FINAS the Finnish Accreditation Service of Biohit Oyj e Operates under the Centre for Metrology and e Assessed against the international ISO 17025 Accreditation standard e National accreditation body under the Ministry of e Accredited by FINAS since year 2000 Trade and Industry e FINAS registration number K041 A04 2003 e Meets the requirements stated by GLP e Still one of the few internationally accredited Member of the European Cooperation for pipettor calibration laboratories in the world Accreditation EA and one of the signatories of all FINAS COFRAC and UKAS existing Europea
109. with Mixing e Multi Dispensing e Diluting e Diluting with Mixing d e n e bspeeds for aspirating and dispensing di i Tip cone design allows easy tip mounting from Direct charging makes the ePET a cost T E m trays and visual seal verification effective alternative for electronic pipetting rd ET dd Models 100 ul offer replaceable Safe Cone Filters to help prevent contamination and damage Stands amp Accessories Cat No Item V Tpson pages sisa 710999 ePET Stand for one pipettor Filters on page 56 725620 Linear Stand B Pipettor selection guide on page 76 711002 ePET Replacement Battery Ergonomics on page 72 ePET Single Channel Performance specifications and ordering details Cat No Channels Volume Increment Test Inacc Impr Safe Cone Filters Range pl ul Volume ul 96 Standard Plus 71052XET 1 channel 0 10 10 0 90 96 0 50 96 B A L M 5 1 00 96 0 80 96 1 2 50 96 1 80 96 0 2 12 00 96 10 00 96 71001XET 1 channel 1 00 100 0 40 96 0 15 96 C O V 50 0 70 96 0 30 96 10 2 00 96 1 00 96 5 2 50 96 1 80 96 71002XET 1 channel 5 00 1000 0 40 96 0 15 96 721006 721016 E G S 500 0 70 96 0 20 96 100 1 50 96 0 50 96 50 2 00 96 1 00 96 71004XET 1 channel 5 00 1200 0 40 96 0 15 96 721006 721016 H T Z 600 0 70 0 20 120 2 00 96 0 60 96 50 2 00 96 1 00 96 71050XET 1 channel 50 0 5000 0 50 96 0 15 96 721006 721016 J 2500 0 80 96 0 20 96 500 0 80 96 0 30 96

Liquid Handling Products Catalogue 2008

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