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USER`S MANUAL

1. Found New Hardware USB Device Biopromin LTD The software for this device has been successfully installed Windows has finished installing the driver software for this device USB Device AMP Biopromin LTD USB Device AMP Biopromin LTD Device driver software installed successfully If you device was completed with special key Guard ant Stealth Il Put Guardant Stealth Il into a USB slot of your com puter s x Installing device driver software Click here for status Guardant Stealth Net II USB dongle Device driver software installed successfully The process of connection up the device AMP to your computer and installation of all drivers is finished So you can pass on to adjustment of the program USPIH 21 Setup the program USPIH 21 1 Please start the program 21 2 The program will start in English Parameters F2 Hood test be Calculate F4 Write F5 Start F9 Print F11 About ap Ukraine Russian BS English H Romana fa o Polish Italiano Slovenia UAE Print setup Report Setup Breath Frea globin f125 95 Erythrocytes 17 Lymphocyte 23 09 Leucocytes 942 00 Plasma Ca concentration 2 44 Plasma Na conc 146 1 Plasma conc 4 Thrombocytes 264 6 21 3 Setup a report of diagnostics for pr
2. Amylase 17 2 Quant of ass 02 ml min Skin blood The cardiac work Very low density lipoproteins VLDLHOSt Myocardial 02 consumption S17 Blood flow to other organs ME The spectral wlength abs of CO2 in bt Low density ipoproteins LDLJ242_ Fibrinogen 21 The creatine kinase of muscules The spectral length abs of N20 in High density lipoprot HDL 1 58 Plasma albumen E80 The creatine kinase of cardiac 35 28 The time of lesser circulation 228 Vital capacity VC 1875 03 Creatinine concentration The time of systemic circulation IBN The max flof of PF foo _ Dopamine The wasting power of ife suppor pH of the gastric juice N Test Tito 755 The concent of lactic acia NN The work rate of assimil sais pH 741 er EN Conjugated bilirubin 5 6 Cholesterot 48 The time of single load 373 INS Ghtaninic cid The respirato tacto Testosterone in urine oc lf 00697 cerebral blood flow on 100g of tissue Total estrogen 15 Close this window Alt F2 This panel has colored windows red the parameter is higher or lower than norm blue the parameter is normal white the parameter doesn t compare with norm yellow the parameter doesn t satisfy the norm IT IS IMPORTANT Please remember there is no o
3. Plasma Ca concentration 244 The plasma density 1053 B lipoprotein Acetylcholine 83 5 Plasma Mg concent Volume of cite blood B37 B lipoproteid E1ythrocyte acetylcholinesterase 2513 Plasma K 14123 Minute vol of blood circulat The concentration of urea 39 Plasma Na concentr 4617 Deficit of cite blood Glucose concentration PO interval 0740 Begin of ibrilaion2 4 The rate of 02 delivery to tissue C02 discharge 27362 QT interval sec 0 464 End of fibrilation 329 Gaseous exchange surface C02 content in arterial blood QRS interval sec O111 Thrombocytes 2646 Vital capacity VC 02 content in venous blood 63 8 Myocar contr of the left ventricle of heatt 47 3 Haematocit 433 The transport of oxygen 9849 The rate of CO2 production ml min 2308 Systolic arterial pressure 125 0 AST cuanto assimil02 on 100 grof tis 18 Myocardial blood flow Diastolic arterial pressure 787 a 02 content of arter blood 36 86 Muscle blood flow The resistance of lesser circulation 1425 ASTE 52 The cardiac ejection O27 Cerebral blood flow x ISO Third ventricular width 3rdvw ALE 233 Quant of 02 on 488 Hepatic portal flow 0407 Pressure of spinal fic ALT asT OS76 _ Pulmonary Ventilation Renal flow 2 Central venous
4. At left side of initial window of USPIH program pic ture 9 there is a field for loading demographic and physiological data of patient picture 11 N Remark Name zzz TEST Weight 7 Puls 7 Breath Freq Picture 11 field for filling in demographic ologic data of the patient Function of rows on data loading field e Remark notices connected with patient e g ward or any other e Name name of patient e Sex sex of patient 1 0 e Age age of patient e Weight weight of patient e Pulse rate pulse arte of patient e Breathing rate breathing rate of patient Filling in the Remark Ward filling is not obligatory is to be made by letters other fields are to be filled in by numbers Name Sex At middle field of initial window of USPIH program picture 9 there is a blood test and metabolite results data field picture 12 Hemoglobin 128 95 Erythrocytes 17 Lymphocyte 23 09 Leucocytes 32 Plasma Ca concentration 2 44 Plasma Na conc 146 1 Plasma K conc 4 123 Thrombocytes 2626 Haematocrit 39 Plasma albumen Cholesterol Picture 12 Field of view results of blood test and me tabolite examination Field at right of results indication field shows names of previous patients in alphabetical order and at very right side there is a field to indicate test time se quence picture 13 7 180 interva
5. When you press this button the program makes a calculation of parameters it de fines them The definitions will be made automatically but if it is necessary to specify correct weight pulse or smth else you should press the button above To save an information about patient in the database gt Exit When you press this button you will leave the program These are buttons for navigation through records in the database pass on the first records in the database pass the last records in the database pass to the previous records in the database pass to the next records in the database pass to the next or previous records in the da tabase delete a patient s card edit record save information about patient the data base ATTENTION To save information about patient in the database you should OBLIGATORY press this button after testing a patient and manual definition of blood formula ATTENTION Unfortunately the database supports only unique name of records So if you have already had a patient Ivanov Ivan in your database you will not save another patient with the same name There will be displayed the following window Noninvasive automatic blood test by Malyhin x Key violation In that case you can write in the field Name Iva nov lvan
6. 10 Calcium Ca in plasma norm 9 00 12 0 976 11 Magnesium Mg in plasma norm 0 7 0 99 0 873 11 Magnesium Mg in plasma norm 1 6 2 60 237 mgidL 12 Potassium in plasma norm 3 48 5 3 4 123 12 Potassium K in plasma norm 13 59 20 7 16 10 mg dL 13 Sodium Na in plasma norm 130 5 156 6 146 1 13 Sodium Na in plasma norm 300 360 335 77 Picture 8 Preview of examination results on the screen 7 Normal use of analyzer 7 1 General safety rules It is prohibited to use the analyzer if ambient temperature is higher than 35 C or lower than 10 C humidity is higher than 95 96 aggressive vapour present in the air dusty spaces direct sunshine strong electric and magnetic fields present moist environment 7 2 Safety measures a It is prohibited to use the analyzer in case of dam aged cable isolation b Before use make a visual inspection of case of analyzer that there are no any broken or torn parts or other kind of mechanical damage c Avoid the analyzer against moisture condensation In case of fast ambient temperature change allow at least 30 minutes to evaporate the moisture d It is prohibited to connect any cable to any socket or disconnect any cable from any socket if the PC is switched on e Power cable of PC shall have protective ground wire and the plug shall have ground connection and shall be
7. Download update Download USER MANUAL VISTA n Press the button if you want to open a loading window immediately Put the serial number for example 38081010 of you device AMP and press an arrow Please enter the serial of your AMP device Serial Click to download update Press Save Do you want to open or save this file i Name biolika5 zip Type Compressed zipped Folder 1 67MB From www analizator amp com ua mam n n V Always ask before opening this type of file While files from the Intemet can be useful some files can potentially harm your computer If you do not trust the source do not open save this file What s the risk Select a folder for saving for example Desktop Press Save QU m osko Search i Organize id New Folder Favorite Links Name Desktop SB Recent Places E Computer E Documents Public Pictures Music Computer More Date modified xj Folders Network w Filename biolika5 Save as type Compressed zipped Folder 7 Ce Hide Folders When the file biolika5 zip is downloaded unpack it please Search Extract All Open With Share Restore previous versions Send To Please press Extract Q 1 Extract Compressed Zipped Folders Select a Destinati
8. 3 Build up and structure of the non invasive screening analyzer APM non invasive screening hemogram analyzer and the PC connected via UBS port is seen at picture 2 Non invasive screening hemogram analyzer with rigid plastic case has a following main parts processor unit at PCB analyzer unit interface processor connected to USB bus of PC socket for patients cable and cable of PC interface with USB port On front plate of device the patients cable socket LED for indication of PC and analyzer connection and USB bus for PC connection Five sensors connected to analyzer measure tem perature of patients reference point with accuracy not less than 0 5 C Parameters of temperature are sent by sensors with speed 56700 bit s to central processor unit of the AMP non invasive screening analyzer Demographic and physiological data loaded from key board also are sent there Data given are processed by central processor unit and are sent to PC which makes them possible to view and print Picture 2 AMP non invasive screening hemogram analyzer and PC connected to it 3 1 Color coding of cables Chart 2 Connection points of sensors and colour coding Connection point of sensor Colour code Bifurcation of left artery Blue Bifurcation of right artery Green Left armpit axillaries Yellow Right armpit axillaries Pink Abdominant area umbilicus pa Red raumbilicalis 4 Control of the s
9. F11 About IE Contents FL X Topik Ctr Fl 217 Lymphocyte 23 09 Leucocytes 43 concentration 2 44 180 intervals 360 intervals 720 intervals Plasma Na 146 1 Plasma K conc 4 123 Click on the button in the appeared window You will be re directed to a web http www analizator amp com ua en About USPIH Certificates and patents Support H News Noninvasive hemogram analyzer allows to make a complex test of the state of p It determines 117 biochemical hemodynamic and immunological parameters of a Hoes tin the mationtn had D Choose the tab Support Then click How to up date the software Click on icon Update for the program USPIH RPC BioPromin LTD 61038 Ukraine Kharkiv Khalturina str 50 apt 2 38 037 377 97 87 40 740 252 112 20 100 595 100 86 139 109 902 62 Arabik Language 375 296 765 494 38 067 44 12345 International centr of information and innovation technologis bioluch yahoo com Contact form 3 Load to your computer updating file biolika5 zip Save it to the f and start updating 4 The updating will be done automatically Start program USPIH button Record to index your base data Now you can work as u e A qe Update for the program USPIH USER MANUAL for the device AMP VISTA
10. Gv Computer Local Disk gt Program Files USPIH Search Mi Organize Bum P Compatibility Files Eome Dak Name Date modified Type Size 1 FTDI 10 28 2017 8 13 PM File Folder E Documents s 1 FTDI 98 ME 10 28 2017 8 13 PM File Folder E pd FTDI WIN2000 10 28 2017 8 13 PM File Folder E Music FTDI XP Vista x64 10 28 2017 8 13 PM File Folder More siouKas 10 28 2007 12 37 Application 1 190 KB cann 2 8 17 2004 4 32 PM Application 80 Ji Adobe x is GSREMOTE 1 25 20057 30PM Application 320 KB 27 DRV 11 3 2005 2 57 PM Application 84 Ahead FEF 1 MiniReg 9 8 2020 8 53 PM Application 13KB 1 Common Files Dsetups 7 18 2007 5 30 PM Application 370 KB B unins000 10 28 2017 8 13 PM Application 671 KB 1 Internet Explorer p Press the button Next Guardant dongles remote programming This utility allows you to update dongle s memory contents in whole or in part as well as to prolong license term of the protected program Select the required operation and press Next gt to start update session Prolongation of the license term of the protected program En Press the button Next Guardant dongles remote programming The number question appears to have already been generated In this case you should select Process number answer to complete update started during
11. it is nec essary to analyze blood circulation in the inner organs and creatinine kinase activity Special attention need to be paid to the medical history taking 93 H2 concentration in gastric juice The number of hydrogen protons is related to the whole complex of biochemical transformations First of all they are re lated to the interactions between gastrointestinal hor mones GIH glucagon vasoactive intestinal polypep tide VIP and gastroinhibiting intestinal polypeptide The interaction of these hormones defines active so dium participation the latter being main plasma cation influencing venous pressure Rise in venous blood pressure causes hydrostatic pressure to increase When hydrostatic pressure is higher than oncotic pressure this can cause electrolytes out of intercellu lar space This phenomenon leads to hypovolemia and activation of the juxtaglomerular apparatus of kidneys This results in stimulation of the adrenal cortex and increase in aldosterone secretion In a whole these factor combinations give rise to the changes in pH en vironment and organotrophic disorder 94 Blood pH is a concentration of hydrogen protons participating in the tissue respiration under which mi tochondria supply required energy in the form of mac roergic phosphates it is necessary to supply oxygen and to release carbon dioxide The oxygen is supplied to the cell with blood flow likewise carbon dioxide is released from
12. s Brasil Portugu s Portugal Russian Sloven ina Slovenski Suomi 19 5 Press the button Next gt Welcome to the USPIH 6 5 Setup Wizard This will install USPIH 6 5 on your computer lt is recommended that you close all other applications before continuing Click Next to continue or Cancel to exit Setup 19 6 Press the button Next gt Select Additional Tasks Which additional tasks should be performed Select the additional tasks you would like Setup to perform while installing USPIH 6 5 then click Next Additional icons Create a desktop icon 19 7 Press the button Install Ready to Install Setup is now ready to begin installing USPIH 6 5 on your computer Click Install to continue with the installation or click Back if you want to review or change any settings Additional tasks Additional icons Create a desktop icon Please wait while Setup installs USPIH 6 2 on your computer Installing Please wait while Setup installs USPIH 6 5 on your computer Extracting files C Program Files USPIH USPIH_EN CHM 19 8 Press the button Install this driver software an 92 Windows Security Windows can t verify the publisher of this driver software gt Don t install this driver software You should check your manufacturer s website for updated driver software for your devi
13. Pulavskyi data collection from reference point After switching on Analyzer runs self test program to inspect readiness of the software By implementation of the users software Analyzer can be set to different modes 2 2 Functions of the Analyzers software e Loading of the patients demographic data and physiological data to the memory of the Analyzer e Data collection from sensors and data processing e Data view on the screen e Saving the data to database e Printing out of the results 2 3 Minimum requirements of the PC hardware Processor Pentium or equivalent RAM min 32 Mb 85 ns HDD 4 3 GB 17 ms CD ROM Display SVGA 14 17 definition 1024x768 pixels 2 4 Ambient conditions Working ambient temperature 10 35 C Atmospheric pressure 101 3 4 kPa Humidity max 80 25 C non condensing IP Class IP Class at side of patient BF EMC in accordance with EN60601 1 2 2002 Analyzer IP Class IP 20 Amb temp of transportation 50 C 50 C Measuring time range 180 360 720 s 2 5 Data of patient loaded prior to examination Data to be loaded by keyboard prior to examina tion Name and Surname of patient Age of patient Weight of patient Pulse frequency of patient Breath frequency of patient 2 6 Examination data Blood of patient haemoglobin concentration HGB mg l or mmol l haematokryte HCT red blood cell RBC 11072 T I white
14. be displayed the following window Noninvasive automati 3 Warning Error parameter Press OK There will be displayed a confirmation for deleting a wrong card Confirm xa o Delete record Please confirm deleting a wrong patient s card and press OK A card will be deleted If there were some wrong cards in your database you should do actions described above till all wrong cards are deleted close program USPIH press the button Exit 22 9 Calculation of examinations quantity not for all versions of the device The program calculates examinations quantity auto matically You can see a quantity of remaining exami nations till software update at the right corner of sta tus bar There are 9 more examinations in this example As a quantity of remaining examinations is less than 10 a status bar is red ATTENTION If status bar of the program USPIH has changed its color to red please connect with your provider of the program and device AMP for renewal your GUARDANT key look part 25 Let him know the number of your device and exchange your GUARD ANT key for new one with updated software NOTES If the remaining quantity of examinations is 0 the program USPIH will not work you couldn t ex amine new patients 23 How to update the software 23 1 To update the program USPIH click and choose UpDate USPIH Print
15. be printed out in form of medical report Non invasive screening hemogram analyzer works in time multiplex mode with repeating data collection Data sending speed to PC is 56700 bit s Quantity of the measuring data stored in memory is not less than 64000 Calculation of the data of blood test parameters is made by special examination algorithm named Ma lykhin Pulavskyi method Ukrainian Patent Nr 3546 A61B5 1 4 The intended field of application of the ana lyzer Intended field of the application of the device clinics medical research centres sanatoriums and other medical institutions to provide preliminary finding ex amination Schematic diagram of the device is shown on draw ing 1 Sensors AMP analyzer HE 9 Drawing 1 Schematic diagram of the AMP system Non invasive screening hemogram analyzer is sealed by two seals placed on fixing bolts under the case of device and near connectors 1 5 Risks of the use of AMP non invasive screen ing hemogram analyzer and limits of examination method Examination cannot be executed in the following cases e patient has a fever e there are inflammations or purulent places on the body of patient close to the biological points where sensors are to be placed or lymphatitis e there are scartissues on any of the bioactive surface e there are fresh recovering wounds after surgery or so on any of the bioactive surfaces e in cas
16. conform with mains socket f Data processing units connected to device shall be used with safety transformer which shall meet re quirements of standard MSZ 60601 1 1997 related to medical devices e g ST 200 transformer made by Standel Ltd g Do not twist the mains cable and place it the way to avoid its damage and against jamming among other objects h It is prohibited to use aerosols and liquids for cleaning the device i Always place the analyzer on stable and solid sur face j Always restart the PC allowing 20 minutes at least k It is prohibited to use the analyzer in tinderbox e g in room where flammable sleeping draughts are kept 8 General description of the USPIH software Most of the operations connected with analyzing are executed by USPIH software running on PC USPIH software runs under WINDOWS operation system USPIH program can be recalled by clicking by mouse at USPIH icon at desk or Start button on bot tom of Windows tools and then select the USPIH program from All programs menu list The initial win dow of USPIH program is shown at Picture 9 L Noninvasive automatic blood test by Malykhin A V olo Setup Parameters F2 Calculate F4 Write F5 Start Print Fll About 0 N roses Hemoglobin Remark Erythrocytes Dass TEST Lymphocyte Sex 1 Leucocytes 7 Age 77 Plasma Ca concentration ight
17. glucose concentration reaches 75 e 20 mg by the Hagedorn Jensen method The level of glucose is regulated by central nervous system Ex ogenous glucose is processed in the digestive tract and transported to the liver Amino acids glycerin and lactic acid participate in the glucose formation Se quence of the glucose formation processes ensures glycogenesis resulting in the formation of liver glyco gen Later on liver glycogen undergoes changes in the so called glucose blood pool glycolysis glyco genesis and aerobic decomposition resulting in the formation of CO2 n H20 Lipogenesis supporting lipid synthesis in the tissues biosynthesis of the substituted acids and protein synthesis The changes in sugar level may be considered as a result of excitation of the metabolic centers by pulses of the energy starved chemoreceptor cells The liver ensures maintenance of the constant blood sugar level Its spare capacities in this regard are ensured by the interaction of somato tropic hormone insulin and glucogon Synchronism in working of this system is ensured by the regulation of glucose consumption through lipid oxidation and en hanced intake of glucose in the intestine with the help of thyrotrophic hormones thyroxin and adrenocortico tropin 52 Triglycerides TG belong to the energetic sub strates TG are important constituent of food used to recover metabolic consumed energy An adult organ ism receives 60 80 g fat
18. month for cable with 5 sensors counted from date of commissioning of analyzer but not more than 30 days counted from the date of manufacturing Within a warranty period manufacturer will exchange the faulty device Should the seals are broken or there are mechanical or chemical damages on the device user lose the guarantee Over the guarantee period all the works are to be paid to manufacturer in frame of separate contract 18 Execution of destroying After its rollout analyzer shall be transported to man ufacturer s site From the point of view of saving ecological environ ment instead of destroying the device it should be re turned to the dealer 19 Install the software Be sure you have Administrator rights on your computer before installation 19 1 Please make sure that a computer has a free USB slot and any attached printer before installation the program USPIH 19 2 Put into a CD ROM drive the purchased installa tion disk 19 3 There will appear the following menu on your display You can start installation when click by the in scription Run Setup USPIH exe lil AutoPlay E e DVD RW Drive D AMP a4 200020303 Always do this for software and games Install or run program Run Setup USPIH exe i General options Open folder to view files using dows Explore Set AutoPlay defaults in Control Panel 19 4 Select Setup language and press the button OK Portugu
19. quence ends label Stop of menu button will change to Start label again and the program will stop calculation Test is successful if results are the same as it shown on picture 19 with following conditions Setup 2 L Noninvasive automatic blood test by Malykhin A V Calculate F4 Write 5 Start 1 Print F11 About 7 Breath Freq 00 00 Hemoglobin 128 Erythrocytes 4 17 Lymphocyte Leucocytes Plasma Ca concentration Plasma Na conc Plasma K conc Thrombocytes Haematocrit Plasma albumen Cholesterol CENE eat Diagnose ver 6 52 Write FS gt Exit Picture 19 Analyzer function test result In fields LSA PSA LPV PPV ABD the same data will appear e g 33 Difference between data shall not exceed 0 1 Should the device not meet that requirements it shall be considered faulty and its use is prohibited until its repair 10 Execution of non invasive screening blood test and metabolite examination 10 1 Make a non invasive screening blood test and metabolite examination as it is described in para 6 Pay attention to place sensors in color se quence as it is described in para 3 1 10 2 Diagnosis saving data processing and activation are subject to local regulations and rules 10 3 Remove sensors when examination is finished 10 4 Switch off
20. the PC 11 Cleaning and disinfection of analyzer and its accessories 11 1 Wipe case of analyzer by soft squeezed wet cloth dipped to soap water 11 2 Disinfection of analyzer surface is to be made by disinfectant approved by Ministry of Welfare Avoid analyzer against getting in the liquid inside during cleaning and disinfection of analyzer case 11 3 Clean case of analyzer by dipped to soap water squeezed cloth 11 4 Disinfection of cables is to be made by disinfec tant approved by Ministry of Welfare 11 5 Disinfection of sensors is to be made by 96 purity spirit Do not wipe sensor by cloth as it may cause scratches on its surface To provide life expectancy of analyzer cables and sensors it is PROHIBITED e to bend cables of sensors and PC e to remove sensors from patient pulling the cables or to pull cables from sockets e to wipe surface of sensors to clean them or to use any solid abrasive materials for cleaning 12 Maintenance of the non invasive screening hemogram analyzer Maintenance of the analyzer is provided by staff of user in accordance with timetable in Chart 3 Chart 3 Maintenance of the non invasive screening analyzer Timetable after every Sig trans orta day use riage pos function test chapter E y 10 para 1 7 gally visual inspection of analyzer connections daily or cables and sensors for if required damage
21. thus ensuring sufficient cerebral blood flow per 100 g tissue It is understood that one of im portant indices of cerebral blood flow is a width of third ventricle Normally it is 4 5 6 mm The size of third ventricle is greatly influenced by a number of factors involved in the regulation and distribution of water me tabolism in the body Adrenal medulla hormones adrenalin noradrenalin and dopamine are of signifi cant importance They can be treated as successive links of amino acid phenylalanine and tyrosine trans formations Due to the influence of pituitary thyrotro phic hormone on thyroid proteolytic enzyme are acti vated which release thyroxin and triiodothyronine form the bond with thyreoglobulin molecules The primary points of thyroxin application in tissues are cytomem branes nuclei and enzymes of the biological oxidation system Thyroxin increases generation of heat which dissipates the environment Triiodothyronine in creases oxygen consumption by the tissues heart in particular Concurrently there is a change in heat generation degree which is defined by catecholamine deficiency Generally catecholamines are considered to be humoral regulatory agents of sympathoadrenal system The biological effect of the latter is the release of energy stimulation of glycogenolysis lipolysis oxi dative processes Catecholamines activate nervous system changing heart rate and increase peripheral circulation in so
22. 2 3 Put the microprocessors on a patient each color for corresponding field on the bifurcation of aorta at the left BRUE side in the area of cricoid s cartilage on the bifurcation of aorta at the right GREEN side in the area of cricoid s cartilage in the left axillary crease like a ther mometer in the right axillary crease like a thermometer on the umbilicus navel If a patient hasn t a navel you should put the mi croprocessor to the region where the navel was before surgery VIOLET RED 22 4 Press the button F9 on your keyboard or START in the menu An information processing will be begun It will last 360 sec and blue line will show a progress of the device working An interval of examination in default it is 360sec 7 180 intervals 360 intervals C 720 intervals An interval of examination can be changed during the process of the device working You should pay atten tion to the color of temperature figures they couldn t be red If some of them s red this microprocessor was put in wrong way Put it again From version USPIH 6 4 interface of the program was changed There were added the indicators of 5 microprocessors application accuracy The first indicator changes its color from red to green when the difference between temperatures in fields of left and right carotid artery bifurcation is less than 0 5 the temperature in 5 fields be
23. 2 or Ivanov Sergey etc So you can see that the patient Ivanov Ivan come to test repeatedly and Ivanov Sergey was another patient Attention when you add a new patient and press the button the program adds the unique number after every name Please DON T DELETE IT and all records will be unique in your database 22 2 How to fill in a patient s card Please fill in the following fields Remark This field is for short overhead information optional information For example from which clinic or hospital a patient is Name Patient s name and surname Sex male man or female woman Attention You should write only a letter m or M w or W It is recom mended write a figure 1 for male and figure 0 for female Please don t try to put any other letter Age complete number of years from 6 till 99 Weight complete number of weight kilogram Puls quantity of heartbeats during 60 seconds You must define it exactly You can use pulse sensor POLAR if you have any problems with definition of heartbeats quantity by hand You can order this sen sor in our company or buy it yourself Breath Freq quantity of breathes during a minute Diagnose A diagnosis or complaints that a patient has before examination This field supports 250 sym bols So write shortly please Diagnose ver 6 52 IT IS IMPORTANT Don t fill in other fields They will be completed automatically 2
24. 4 11 Check up of temperature range at reference points as it is seen on picture 23 arranged as de scribed above a Set the thermostat temperature at 24 C check up after 30 minutes whether the temperature of the ther mostat reached the set temperature 24 0 5 C and then read out and record temperature of Vaseline indi cated on precision thermometer and temperature measured by all the sensors of the AMP non invasive screening hemogram analyzer 1 2 3 4 5 b Repeat the procedure at vaseline temperatures 26 C 28 C 30 C 32 C 34 C 36 C and 37 C set by thermostat reading temperature indicated by precision digital thermometer and temperature measured by each of sensors of AMP non invasive screening he mogram analyzer 1 2 3 4 5 see Chart 6 Chart 6 24 26 28 OT A OT A Ne AMP A 1 24 30 0 05 1 1 2 2 2 24 25 3 25 75 3 25 7 0 05 28 4 3 4 4 4 28 36 0 04 5 5 5 30 C 32 34 OT A OT AMP A Ne AMP A 1 1 1 2 30 22 0 02 2 2 30 2 3 31 8 3 344 3 4 4 4 34 46 0 06 5 5 30 75 0 05 5 36 C 37 OT A OT Ne AMP A 1 36 05 0 1 1 2 2 35 95 3 37 15 3 37 10 0 05 4 4 5 5 Relative error of temper
25. 4 60 or 38 5 in men 50 70 or 42 Intercellular water women 30 45 or 28 5 Men 35 50 31 5 Extracellular water women 14 22 or 9 8 Men 15 22 or 10 5 In tracellular water women 10 15 or 7 1 Men 10 18 or 7 4 Plasma for women 4 5 or 2 8 Men 3 5 4 5 or 3 2 l 113 114 Blood flow per 1 gr of brain tissue and blood flow per 1 gr of thyroid gland ensures me tabolism and energy consumption through water distri bution in the body metabolic free fraction and fraction bound in the colloid systems with the molecules of or ganic substances Per 1 g glycogen and protein de posited in the tissues 1 5 and 3 ml water are held re spectively As a result of catabolism in human body 300 400 ml water is produced daily Quantity of water determines the nature of decomposing substrates With 100 g fat being oxidized 107 ml water is pro duced with 100 g protein 41 ml water with 100 car bohydrates 55 ml water All body water is renewed in 4 weeks Whole system of the metabolism regulation is determined by the blood flow per 1 f brain tissue and blood flow per 1 g thyroid gland 115 Tissue oxygen extraction index is interrelated to the cell membrane permeability where cholesterol and phospholipids are of great importance By hy pothesis for the nature of bonds involved in the inter action of phospholipids polar sites and cholesterol cholesterol hydroxyl and ethereal ox
26. 420014242 Browse for driver software on your computer Search for driver software in this location Browse V Include subfolders Next Select the folder C Program Files USPIH FTDI Select the folder that contains drivers for your hardware To view subfolders click the symbol next to a folder gt Common Files gt EXE gt 1s Internet Explorer gt J Microsoft Games gt J Movie Maker gt 1 MSBuild gt J Paint Shop Pro 5 gt Realtek b Reference Assemblies gt J SiSoftware USPIH Jj FIBI j FTDL98 ME gt Jo New 12 FTDI WIN2000 J PACIENTS Ca Ga Press the button Next Browse for driver software on your computer Search for driver software in this location C Program Files USPIH FTDI Include subfolders 20 6 Press the button Install this driver software an Windows can t verify the her of this er software gt Don t install this driver software You should check your manufacturer s website for updated driver software for your device gt Install this driver software anyway Only install driver software obtained from your manufacturer s website or disc Unsigned software from other sources may harm your computer or steal information See details Installing driver software Installing driver software b 0 20 7 Press the button Close
27. 77 Plasma Na conc Plasma K conc 2123 7 Thrombocytes Breath Frea 18 Haematocrit Plasma albumen Cholesterol Diagnose ver 6 52 33 zi 5 00 00 e Picture 9 Initial window of USPIH program after se lection of the program Upper tool menu at window there are the following buttons of menus picture 10 e Setup e Parameters F2 e Calculate F4 e Write e Start e Print e About LJ Noninvasive automatic blood test by Malykhin A V Setup Parameters F2 Calculate FA Write F5 Start Print 11 About Picture 10 USPIH program menus Setup menu contains the followings factory se tup 1 Language 2 Report setup 3 Print setup Parameters F2 menu contains further additional pa rameters calculated by program and view of the pre liminary report for diagnosis necessary for doctor Calculation F4 menu serves for preliminary calcu lation of blood test parameters and other biochemical data Write clicking to that button program calculates all the calculation parameters and save that to database It is important in case of use new version of the pro gram or for search patients empty or wrong filled in da tasheets Start menu starts calculation of examinations re sults Print menu makes possible preview of data to be printed and printing the results About make possible searching by word in Win dows
28. The triiodothy ronine activity has primary meaning in the oxygen consumption per minute 41 Myocardial oxygen consumption is a value dependent on the functional state of organism When myocardial oxygen consumption increases stomach liver and smooth muscles consume less oxygen which predetermines activation of the enzymes creatinine kinase in particular 42 Deficit of circulatory blood is a depression in the circulating blood volume per kilogram body weight and circulatory minute volume expansion Exposure to the deficit of circulatory blood is attributed to the proc esses regulating water salt metabolism It is under stood that watersalt metabolism is influenced by the thyroid hormones Combined interactions between pi tuitary antidiuretic hormones somatotropic hormone and kallikrein kinin system are accompanied with changes in the plasma density and urine specific grav ity As the difference between plasma specific gravity and urine specific gravity is decreasing we observe drop in the colloid oncotic pressure resulting in the rise of capillary hydrostatic pressure The changes in colloid oncotic pressure and hydrostatic pressure causes water outflow to the intercellular space and depression in the circulatory minute volume and so rise of the deficit of circulatory blood 43 Vital lung capacity in an expiration phase is a lung volume after expiration The more the lung vol ume in the expiration phase the more the pul
29. USER S MANUAL AMP NONINVASIVE SCREENING HEMOGRAM ANALYSER Manufacturer BIOPROMIN Ltd Residence UKRAINE ALTA 941320 001 30 May 2009 TABLE OF CONTENTS Description of the AMP non invasive screening hemogram ana lyzer and its function Technical data of the AMP non invasive screening hemogram analyzer and characteristics of the system Build up and structure of the non invasive screening analyzer Control of the system Software packet Examination of non invasive screening blood test and metabolite test and indication of calculation results Normal use of analyzer General description of the USPIH software Non invasive screening hemogram analyzer function test Execution of non invasive screening blood test and metabolite examination Cleaning and disinfection of analyzer and its accessories Maintenance of the non invasive screening hemogram analyzer Search of fault and elimination of faults Periodic inspection of non invasive screening analyzer Documentation of manufacturers and periodic inspection Transportation and storage Warranty by manufacturer Execution of destroying Install the software Connect up the device AMP to a computer and install the drivers Setup the program USPIH Work with the software How to update the software Update GUARDANT key Possible problems and troubles Description of metabolic and biochemical indices Certificate 1 Description of the AMP non invasive screening hem
30. al current of blood ml min IV The time of systemic circulation V 2 Me mek oo Oleh The dopamine hydroxylase IV The hepatic portal current of blood ml min v The conc of H2 of gastric juices v Test Tito 17 Theconcentoflacicacid v The nephritic current of blood ml min IV The bilirubin V PH K The The skin curent of blood ml min 17 Conjugated biliubin v SH v Triglyceride The other organs current of blood ml min IV Unconjugated bilirubin My address Em The creatine kinase of muscules 7 The creatine kinase of cardiac IV The glycogen The work rate of assimil oxygen I The time of single load IV The respiratory factor IV The tyrosine v Cerebral blood flow on 100g of tissue 2 The testosterone of urine v The total estrogen v Extracellular water Celular water Total water The blood flow per 1gr of thyroid gland v The blood flow per Tar of cerebral tissue Basal pressure of sphincter Oddy index of protrombin v The index of extraction of tissue oxygen Then you ready for a work with the program US PIH 22 Work with the software 22 1 A description of the program USPIH interface 22 1 1 The menu LJ Noninvasive automatic blood test by Malykhin A V Setup Parameters F2 Calculate F4 Write F5 Start F9 Print Fl1 About Setup use to setup an interface language an
31. ardant Stealth II key 25 3 Problem After starting the program USPIH the following panel appears Error Ea Device not found Solution a The device AMP hasn t connected to your com puter Connect it please b A USB cable is damaged please exchange it 25 4 Problem At attempt of updating the window looks like o Navigation to the webpage was canceled What you can try Refresh the page Solution Check up connection options to the Internet 26 Description of metabolic and biochemical in dices covered by Malykhin Pulavskiy USPIH Soft ware Electrolyte metabolism 10 Calcium is a cation constituting a part of blood cells and electrolytes Its normal concentration in the blood plasma ranges from 2 02 to 2 2 mmol l It is regulated by parathyroid gland bone tissue and pitui tary thyrotropic hormone The regulation of calcium in the organism is attained by triiodothyronine and tetraiodothyronine metabolism optimization as well as by creatinine kinase of the muscles and heart 11 Magnesium is a cation constituting a part of blood cells Its primary functional purpose is participa tion in the development of conductivity and contractility of those muscles constituting a part of vascular wall Magnesium normal value ranges from 0 7 to 1 0 mmol l It is regulated by the activation of creatinine phosphatase phosphorylation In case magnesium level is less than 0 7 mm
32. are recommended 1 7 Found New Hardware Windows needs to install driver software for your AMP 42001 42 42 Windows will guide you through the process of installing driver software for your device Ask me again later Windows will ask again the next time you plug in your device or log on Don t show this message again for this device Your device will not function until you install driver software Cancel 20 3 Press the button I don t have the disc Show me other options Insert the disc that came with your AMP 42001 42 42 If you have the disc that came with your device insert it now Windows will automatically search the disc for driver software Se INTUITU RUE SSIES SSG TT TCI gt Idon t have the disc Show me other options 20 4 Press the button Brows my computer for driver software advanced Windows couldn t find driver software for your device gt Check for a solution Windows will check to see if there are steps you can take to get your device working Browse my computer for driver software advanced Locate and install driver software manually 20 5 In default the drivers for connection the device AMP to your computer through USB interface are in the folder C Program Files USPIH select Include subfolders Press the button Browse Q3 2 Found New Hardware
33. ates into renal tubular lumen where being combined with hydrogen ion it turns into poorly diffusing ammonia ion In the conditions accompanied with glutamic acid deficit compensatory mechanisms are not able to prevent shifts in the hy drogen ion concentration which leads to the acid base imbalance The reasons can be as follows decrease of respiratory minute volume circulatory inefficiency pulmonary sarcoidosis rheumatoid arthritis acute pneumonia All these pathological states panied with glutamic acid deficit 98 Tyrosine acid is a regulatory amino acid being constituent of the thyroid hormones Thyroxin and triiodothyronine are iodated tyrosine derivatives Blood iodine is captured by thyroid tissue by means of the active concentration mechanism In the thyroidal tissue iodine is peroxidase oxidized to form monoiod tyrosine As a result of tyrosine iodination in fifth resi due diiodtyrosyne is formed Monoiodtyrosine conmi nation results in triiodothyronine T3 Complexation of two diiodtyrosyne molecules leads to the thyroxin for mation T4 Thyroid hormones are of significant im portance for the processes of growth development and pubescence They raise energy consumption in tissues protein synthesis and glycometabolism and affect lipid metabolism 99 Creatinine kinase in muscles Creatinine kinase catalyzes reverse reaction of phosphoryl residue transport from ATP to creatine from crea
34. ature measurement at differ ent set temperatures is calculated by formula below Ta T AMP 100 _ Ot 100 1 Where Twp temperature indicated by precision digital ref erence thermometer C Tamp result of temperature measuring of AMP non invasive screening analyzer C A T amp C data calculated by this for mula shall be registered in Chart 6 Criteria of conformity Amax lt 0 1 C in range of tem perature 24 C 37 C 15 Documentation of manufacturers and peri odic inspection Should the inspection of analyzer has been success fully completed manufacturer issues certificate of con formity and places label on sealing points of analyzer indicating date and sign Should during inspection device do not meet confor mity requirements it is qualified as faulty and shall not be used 16 Transportation and storage 16 1 Manufacturer or its authorized representative supplies the analyzer to the customer Trans portation of the properly packed analyzer is al lowed by any transportation means in accor dance with applicable rules for the transporta tion means 16 2 Analyzer shall be kept in manufacturers pack ing Warehouse shall be clean free of dust acid alkali vapour or other dangerous components Storage life time of device is one year maximum 17 Warranty by manufacturer Warranty period is 24 month for the device and 12
35. blood cell WBC 11091 lymphocyte quantity LYM 96 thrombocyte quantity PLT 11091 serum concentration mmol l serum K concentration mmol l serum Ca concentration mmol l cholesterol concentration CHOL mmol l total protein concentration TP 9 1 2 7 Accuracy of the data of examination HGB 120 180 mg l 10 60 120 and 180 300 mg l 15 HCT 0 37 0 52 I I 10 0 16 0 37 and 0 52 0 65 I I 15 RBC 3 8 6 2 T I 10 96 2 6 3 8 6 2 7 6 15 96 WBC 55 9 6 1 10 96 3 5 9 25 15 Lym 20 35 10 15 20 and 35 50 96 15 96 PLT 140 450 10 80 140 and 450 600 15 Na 133 147 mmol l 10 96 beyond normal range 15 96 3 4 4 5 mmol l 10 beyond normal range 15 96 Ca 2 25 2 65 mmol l 10 beyond normal range 15 96 Cholesterol 2 50 7 80 mmol l 10 96 beyond normal range 15 96 Total protein 60 80 g l 10 96 beyond normal range 15 96 2 8 Details of the whole system Chart Nr 1 Accessories of the whole system Item Mark Q ty 1 AMP ALTA 941320 001 2 Cable w 5 sensors ALTA 941320 002 3 Cable for connecting ALTA 941320 003 analyzer and PC USB bus 4 Manual ALTA 941320 001 RE 1 5 Installation USPIH ALTA 941320 004 1 software on CD 6 Key Guardant Stealth ALTA 941320 005 1 II 7 Cover ALTA 941320 006 1
36. ce ista 5 tware any Only install driver software obtained from your manufacturer s website or disc Unsigned software from other sources may harm your computer or steal information See details 19 9 Press the button OK Borland Database Engine Installation Upgrade The Borland Database Engine will be installed upgraded in the following directory c Program Files Common Files Borland Shared BDE Browse 19 10 Press the button Yes o The specified directory does not exist Create it Completing the USPIH 6 5 Setup Wizard Setup has finished installing USPIH 6 5 on your computer The application may be launched by selecting the installed icons Click Finish to exit Setup When the program is installed there will appear the icons for starting the program USPIH 6 5 on the Desk top and in Quick Launch You are ready to connect up the device AMP and in stall the drivers 20 Connect up the device AMP to a computer and install the drivers 20 1 You should prepare the device for connection to the computer link up the device AMP and cable with 5 micro processors connect the USB cable to the device connect the USB cable to your computer You will see the following message on your display Installing device driver software Click here for status 20 2 Press the button Locate and install driver soft w
37. ced by hormones of adrenal medulla adrena lin noradrenalin and dopamine which regulate car diac tone and lumen 85 Pressure in pulmonary circulation Pulmonary circulation is a low pressure system in a healthy man Average pressure i e pressure over the atmospheric one in the right ventricle and in major pulmonary ar teries makes up approx 15 mm Hg or 130 140 mm CE Issue of the pressure generation is connected with blood volume flowing in the vessels of pulmonary cir culation In healthy man this value makes up 0 5 or 10 of circulating blood volume Veins of pulmonary circulation contain nearly half of blood volume flowing in the pulmonary circulation Healthy test subjects showed increase in the oxygen consumption during muscle work Pulmonary artery pressure rose on the average from 13 9 mm Hg to 17 3 mm Hg Blood vol ume in the pulmonary circulation capillaries is influ enced by lung volume defined as a ratio between 30 and 33 indices 86 In norm width of third ventricle is 4 5 6 mm The size of third ventricle is greatly influenced by a number of factors participating in the regulation and distribution of water metabolism in the body We can distinguish 5 factors which define the flow of body liq uids between various spaces 1 Osmotic pressure related to the difference be tween concentrations of substances dissolved in liq uids which are separated by semiimpermeable mem brane 2 Factor influe
38. comes stable mu 00 126 46 192 190 190 9 Otherwise the indicator is red 124 16 64 or 135 65 249 The second indicator changes its color from red to green when the difference between temperatures in fields of left and right axillary creases is less than 0 5 C the temperature in 5 fields becomes stable SS OO 126 46 192 190 190 Otherwise the indicator is red 124 16 64 or 135 65 249 When the process of examination is finishing you can see the following notice on the bottom of the pan el 132 45 468 11711 Sum 132 450 Different numbers could be there but they must be nonzero If any number is zero you should choose larger in terval for the examination for example you examina tion was 360 sec you should choose 720 sec interval in such case When the progress of examination is 100 all fields of patient s card will be completed The progress line will disappear Hemogram fields will be completed too IT IS IMPORTANT Please remember a blood for mula in itself gives not enough information about the state of patient and prognosis for a disease 22 5 To display the additional parameters of diagnos tic press on your button F2 or Parameters F2 in menu A panel with additional parameters will appear Other parameters zzz TEST Close panel
39. creatine adds phosphorous group and turns into creatine phosphate and then the latter forms creatinine The following amino acids participate in the creatine synthesis ar ginine glycine and methionine Such diseases as my asthenia myatony and myositis are accompanied with abnormal processes of creatine transformation to crea tinine Rise of the creatinine level in serum is seen with kidney diseases Constant rise of the creatinine level is indicative of the disorders of renal filter Doubling of blood creatinine is parallel to the decrease in renal fil tration by 50 48 Dopamine B hydrolase It is an enzyme found dissolved in lysosomes Dopamine B hydrolase activity is attributed to pH optimum If pH in the functioning cell is normal free amino groups of hydrolases in ly sosomes form the ionic bonds with acid phosphate groups of lipoprotein lysosomal matrix These ionic bonds determine hydrolase latency inside lysosomes Destructive processes in the tissue are connected with the pH changes and activity of lysosomal hydrolases The idea is that their activity changes type of the cell membrane construction Dopamine B hydroxylase level decrease is accompanied with the development of various asthenodepressive and asthenoneurotic states 49 Lactic acid It is a final product of glycolysis and glycogenolysis The lactic acid concentration is related with status of the blood circulation in muscles and liver It increases with m
40. d bio regulators Their action is based on the platelet activa tion with serotonin being released The latter is a va soconstrictive agent and a stimulator of unstriated muscle contractions Conditions for thrombosis are provided due to the platelet aggregation and arte riostenosis In this regard main biological mechanisms are chemotaxis stimulation olymorphonuclear leuko cytes aggregation with the latter producing superoxide radicals 27 Certificate EC Certificate Production Quality Assurance Directive 93 42 EEC on Medical devices Annex V ORKI certifies that the manufacturer Number of certificate 5 515 500 0706 Research and Production Complex Biopromin Ltd 30 Selyanska Str atp 32 Kharkiv 61157 Ukraine 50 Khalturina Str apt 2 Kharkiv 61038 Ukraine with authorized representative in EU Inter Kep Ltd Kerepesi t 15 Budapest Hungary for the products Noninvasive hemogram analyzer applies a quality system in the manufacturing process which ensures that the products are manufactured in conformity with the technical documentation referred to in Annex VII and kept by the manufacturer Number of the audit report on the assessment 42 075 2007 Provided the yearly surveillance is carried successfully this certificate is valid until 2012 06 20 Issued by ORKI a Notified Body for the Council Directive 93 42 EEC with identification number 1011 25 First issued Budapes
41. d de tailed setup of a diagnostic report Parameters F2 use to display a panel with addi tional parameters Calculate F4 use to define a blood formula and additional parameters by hand Write F5 use for checking a completeness of the database before the program USPIH ends of working Start F9 use to start up the device AMP and to begin measuring Print F11 use for preparing and printing a report with defined parameters of blood formula etc About itis short information about the program 2 use to open a Help file 1 use to open a Help file F6 use to select Standard panel or CE panel 22 1 2 Timer 00 00 165 It is used for calculation of patient s heartbeats by hand The Timer starts working when you click the left but ton of a mouse on 00 00 After that it works 3minutes and stops automaticaly 22 1 3 Other controls AB Write FS When you press this button all records in the database of patients will be rewrited In other words it ll be carried out indexation of the da tabase Also all patient s cards will be checked wheth er they were filled in right Are they complete or not We recommend you to make a Record at the end of the work with the program If there are any er rors in database the program will stop on a wrong pa tient s card and suggest deleting it We recommend you to follow the program s instructions amp Calc F4
42. e F4 Write F5 Start F9 Print F11 About Name Mashir 3 Sex 1 Thrombocytes an 00 00 50 50 165 Picture 21 Loading the data to program 14 7 Click to Start menu at upper toolbar of USPIH program Label of button will change to Stop 14 8 In field of program running progress under upper menu growing numbers will appear 0 100 and in accordance with examination se quence 180 s 360 s 720 s red green or blue bends will appear filling up from left to right When the time sequence ends label Stop of menu button will change to Start label again and the program will stop calculation 14 9 Test is successful if results are the same as it shown on picture 22 with following conditions 14 10 In fields LSA PSA LPV PPV ABD the 33 0 1 data will appear H Noninvasive automatic blood test by Malykhin A V ola Setup Parameters F2 Calculate FA Write F5 Start Print F11 About 7 N id 3 Hemoglobin zzz TEST Re rk Erythrocyte Name Mashir 3 Lymphocyte sex fi Leucocytes Age 67 oncentration RE na K Puls 76 E hrombocyt Breath Freq 18 Haematocrit Plasma alb ENS D E 200 ver 6 52 ite FS gt Ex 3 NE amp 00 00 S Calc F4 50 50 Picture 22 Result of analyzer function test 1
43. e the patient is in state of psychomotor agitatio e the sensors were not cleaned carefully by alco hol before placing them onto the bioactive sur faces e temperature in the examination room does not exceed range of 18 32 c e in case the sensors do not work properly no any sensor is allowed to indicate temperature be yond range of 27 38 c e in case the atmospheric pressure goes beyond range of 97 3 105 3 kpa 730 790 hgmm in case if the humidity raises over 80 96 e in case if near the analyzer there is other device generating electromagnetic field with frequency be low 26 hz or over 1000 mhz 2 Technical data of the non invasive screening hemogram analyzer and characteristics of the system 2 1 Technical data of the analyzer PC mains voltage 230 V 10 96 50 60 Hz Analyzer mains voltage from USB port U 5 1VDC 1 95 Consumption 0 475 VA Dimensions WxDxH 160mm x 100mm x 45mm Weight 0 35 kg w cables amp sensors IP Class Protection of patient BF accordance with EN60601 1 2 2002 IP Class of Analyzer IP 20 Readiness time counted from switching on max 3 min Time of examination 730s Quantity of sensors connected to Analyzer 5 Range of temperature of reference points 24 42 C Margin of error of reference points max 0 75 C Length of cables for sensors min 1 5 m Connection of Analyze to PC PS bus Method of diagnostic Malykhin
44. echanics of the Circulation translated from English 1981 V P Parins s The Physiology of Circulation In assessing the bloodstream of inner organs it is necessary to analyze level of the myocardial and cerebral oxygen consumption 77 Acetylcholine As to Pokrovskiy s data there are more than 100 methods of chemical cholinicity deter mination in various blood activities Choline esterase activity is attributed to acetylcholine with pH environ ment value pH value has an impact on delivery of acetic acid and this reactions continues until environ ment pH achiebed defined level Choline esterase ac tivity varies widely Distinctive decrease of choline es terase is seen with hepatic diseases hypothyroidism bronchial asthma and rheumatoid arthritis 9 79 81 Cardiomechanics intervals Cardiac beat cycle begins in certain area in the right atrium wall called pacemaker Muscle cells in this area are spe cific they are able to polarize and re polarize from time to time Having begun in the pacemaker depo larization travels at a speed of 1 m s to neighboring walls of right and left atriums causing their contrac tions Then depolarization acts on muscle bundle His band which passes through fibrous tissue surround ing tricuspid valve to interventricular septum Depo larization wave is quickly propagated in this pathway at a speed 5 m s Ventricular depolarization potential on ECG QRS complex lasts less tha
45. ection Diaphragm ba Measuring range 50 760 rometer Hgmm Aspiration hu 2 midity measuring device Measuring range RH 20 90 16 40 C Precision digital Measuring range 0 100 C thermometer error lt 0 036 C Temperature range 0 60 C Measuring accuracy of ther mostat 0 15 C Ultra thermostat 4 with digital read out During periodic inspection of the device unpack the analyzer and keep in the room for inspection at least for 24 hours Execution of inspection provided by service 14 1 Connect patients cable to socket DB9 of ana lyzer and fix it by screws 14 2 Connect USB cable to analyzer and USB port of PC 14 3 Switch on the PC 14 4 Run the USPIH software clicking to icon 14 5 Place sensors into vessel filled by vaseline and place the vessel into thermostat Arrangement is shown at picture 20 Set the thermostat tempera ture 33 C Wait until the temperature of the vase line will be stabilized at level of set temperature Precision digital Ultrathermostat with thermometer thermometer Vaseline vessel Picture 20 Arrangement of periodical inspection of analyzer 14 6 Load the patients data to fields name sex age weight pulse rate breathing rate as it is shown on picture 21 H Noninvasive automatic blood test by Malykhin la Setup Parameters F2 Calculat
46. er The Device Manager lists all the hardware devices installed on your computer Use the Device Manager to change the properties of any device Windows Update Driver Settings Choose whether to check Windows Update for driver software Windows Update Driver Settings Check whether controllers were installed right File Action View Help ml amp q Computer g Disk drives Display adapters DVD CD ROM drives Floppy disk drives eli Floppy drive controllers Guardant dongles IDE ATA ATAPI controllers 2 Keyboards A Mice and other pointing devices E Monitors Other devices 22 Ports COM amp LPT Dll Processors lt gt Storage controllers 4A System devices Universal Serial Bus controllers mem M USB Universal Host Controller 2442 iversal Host Controller 2444 fF Be Be E fF Be Fe fF Fe Fe Be ffl _ USB Root Hub If they were installed wrong or ill worked please in stall them once more 25 2 Problem LED the front panel of the device is blinking Reason the cable with 5 microprocessors is dam aged Solution Let your provider know that and ask him to exchange damaged cable with 5 microprocessors for new one NOTES The exchange of cable with 5 microproces sors will be realized only in a complete with your de vice AMP and Gu
47. hemogram analyzer Name Mashir 3 1 Weight 98 PS 76 33 414 168 0160 746 6979 Vo Characteristic formula M 148 924 Hemoglobin HGB 2 1 120 175 Erythrocytes RBC E10x12 1 1mm3 456 4 619 19 37 17 122 Leukocytes WBC 10 91 43 11 3 7 298 Segmented neutrofiles 47 72 66 320 Lymphocytes Erythrocyte sedimentation rate ESR mm h 1 14 3 626 E 0558 2271 3 11 8 005 1 6 2 25 3 Magnesium Mg in plasma mmol 0 7 0 99 0 971 Potassium K in plasma mmol l 34853 37 1315 1546 141945 NT aera iment D G BG en e 85 English USA ansrt sro lt 1 Pagel 5 Default Press the button to export result to the Open Office Calc Leaving a panel A report of diagnostics gt The same functions be caused by means of the contextual menu Click the right button of a mouse on corresponding record and choose necessary applica tion zzz Print Alt P Alt W to OOffice Write H Export to OOffice Calc 22 8 End of working with program USPIH When you finish working with program USPIH choose in a menu Write F5 or press the following Write FS button If any patient s card has been filled wrong there will
48. holesterol oxidation to bile acids in the liver hepatocytes is main way of the metabolic elimina tion of this hydrophobic compound from organism and bile acids themselves can be considered as a final product of the cholesterol catabolism In addition great role is played by taurocholic and glycocholic acids which are involved in the pH regulation The enzymes of large intestine microflora affect formation of the ste rols not containing carboxylic groups 54 55 Lipoproteins Lipoproteins rich in triglyc erides chylomicrons CM and very low density lipo proteins VLDLP CM are formed in the process of ed ible fat absorption and serve to transport exogenous TG to the sites of utilization cardiac and skeletal mus cles mammary glands etc and depositing adipose tissue Apoproteins of all major groups are found in the CM protein part 56 VLDLP They represent a transport form of the endogenous TG The protein concentration in VLDLP is higher than in CM Lipid and protein compositions of VLDLP are subject to the significant quantitative changes more than in any other LP class Main pro teins of VLDLP are apo B 100 and apoproteins of C group Usually VLDLP lipids are isotropic liquids and they are adequately mobile which is identified by the constant lateral moving inside one particle and be tween particles Practically all TG in the nucleus of LP particle are liquid at 37 C VLDLP are formed in the liver in endopla
49. ies is formed In this relation CO2 generation rate must be lower than CO release rate and total venous blood CO must be higher than total arterial blood 62 generation rate is a biochemical process related to metabolism and oxygen consumption by or ganism CO generation rate is greatly influenced by pH environment and lactate indices 63 69 Internal organ bloodstream in ratio to gen eral bloodstream Whole bloodstream MCV taken for 10096 is distributed among organs Average data are taken from V P Osipov s monograph Principles of Cardiopulmonary Bypass 1976 V A Berezovskiy s Oxygen Tension in Human and Animal Tissues 1975 C Caro s The Mechanics of the Circulation translated from English 1981 V P Parins s The Physiology of Circulation Important indices are car diac and cerebral blood flow When cardiac blood flow decreases below 4 various variants of cardiac circu latory insufficiencies are observed When cerebral blood flow decreases below 13 various clinical vari ants of cerebral circulatory disorders can be seen 70 76 Internal organ bloodstream in ml min Bloodstream of inner organs in percentage terms was recalculated as to the general blood flow in ml min The data used were the same as taken from V P Osipov s monograph Principles of cardiopulmonary bypass 1976 V A Berezovskiy s Oxygen tension in human and animal tissues 1975 C Caro s The M
50. inting To make more detailed setup of a report open menu Setup gt Print setup Noninvasive automatic blood test by Malykhin A V Parameters F2 Calculate F4 Write F5 Start Print Fll About 7 gg Russian English Hemoglobin o Em 2 17 Lymphocyte 2 gt Leucocytes 7 Plasma Ca concentration 2 44 Plasma Na conc 146 1 R fs Report Setup Plasma conc 4 123 r There will be displayed a panel Print setup Tick off the results you want to print Your Essential Elements the name of a company telephones etc will be printed in a heading of report You can adjust the Essential Elements across using space bar Then press the button Exit and a panel Print se tup will be closed All changes will be saved and take effect only after leaving a panel Print setup Tick off a parametrto print it The wasting power of lfe support v Conc of Ca plasma The plasma density The acetylcholine B ipoproteid gr itre IV The acetylcholinesterase of erythr v Cone of Mg plasma v Volume of circ blood v B ipoproteid micromole itre 7 i 2 Cone of K plasma Minute circulat blood The concentration of urea FF The interval PO sec 7 Conc of Na plasma 7 Deficit of cire blood v Mo ue Begin of fibrilation The rate of 02 delivery to issue c C02 discharge 17 The interva
51. l ORS sec v End of fibilation v surface of gaseous exchange content of CO2 gas in arterial blood F7 Contr of mioc of the left vent of heart V Thrombocytes V capacity of lungs 7 The content of CO2 gas in venous blood 7 Too tens itna chemin a Haemelocile v The transpott of oxygen 7 The rate of CO2 production ml min 0 The resistance of lesser circulation v AST V 02 on 100 g7 The myocard current of blood c 2 The width of the 3d vent of cerebrum IV ALT V Cont of 02 in ait blood v The muscles current of blood J7 ASTE The cardiac ejection The cerebral current of 42 IV ie ae Fe tr dw ALTE Quantof assimiLO2 on kg The hepatic portal curent v Diac ALT AST The pul lation fe 2 ventilation riti x The nephilic curent The amylase vi Quant of ass 02 ml min 17 The skin current of blood 17 The cardiac work v Lowest density lipoproteins at of myocardial 02 consumption IV The other organs current of blood The spectral w lenath abs of CO2 in bk Low density lipoproteins 7 Thefibinogen v myocard curent of blood ml min V spectral w length abs of N20 in bt IV i High density ipoprot IV Plasma abumen 7 The muscles curent of blood ml min v The time of lesser circulation v Vital capac of lungs VC IV Concentt of creatinine 7 The cerebr
52. l of protein and lipids in cell membranes Taking into consideration that the AMP non invasive screening hemogram analyzer measures the tempera ture through optic sensors there is no any influence to the patients organism 1 3 Function of the AMP non invasive screening analyzer Principle of function of the AMP non invasive screen ing hemogram analyzer is based on measurement of temperature of biologically active reference point of the human body which data loaded to PC from key board is then processed there Device has five sensors which are to be placed onto so called biologically active points of patients body Bioactive or so called reference points used during examination are following e Bifurcation of the right and left neck artery two points e Right and left armpit two points e Umblical area one point Prior to examination the five sensors are to be placed onto patient and the personal data of him and breath rate pulse rate are to be loaded to PC from the keyboard Then the data collection and calculation software starts Non invasive screening hemogram analyzer proc esses signals coming from sensors placed on body of the patient converts these signals to digital form and passes them to the PC The PC makes processing of the measured data by means of appropriate software and after the neces sary running time makes the measured data visible on the display Result of examination can
53. lation processes reduces high energy phosphate bond formation and increases development of heat which dissipates in the environment Thus oxygen consumption changes to kg This dimension is attributed to the triiodothyronine activity We can arrange organs in descending order in respect of triiodothyronine influence on the oxygen consumption as follows heart gastric mucosa liver smooth muscles kidneys and diaphragm 103 Working level of oxygen consumption It is related to arterial blood oxygenation and hemoglobin ability to bind oxygen and oxygenate tissues To a great extent this process is affected by thyroxin Thy roxin splits oxidation and phosphorylation processes reduces high energy phosphate bond formation and increases development of heat which dissipates in the environment Thus oxygen consumption changes to kg This dimension is attributed to the triiodothyronine activity We can arrange organs in descending order in respect of triiodothyronine influence on the oxygen consumption as follows heart gastric mucosa liver smooth muscles kidneys and diaphragm i e with triiodothyronine activity increasing activity of the oxy gen consumption by heart and other inner organs in creases as well If oxygen consumption by heart in creases oxygen consumption by gastric mucosa liver and diaphragm changes decreases as well This re sults in the deficit of used power for life support 104 One time load time We
54. ls 360 intervals C 720 intervals Picture 13 List of patients and time sequence At left bottom side of the initial window of USPIH pro gram on picture 9 digital stopwatch is shown picture 14 which is to be used during measurement of pulse rate of patient Stopwatch starts by clicking to field 00 00 or pushing buttons Alt S 00 00 Picture 14 Stopwatch Preview is possible by clicking to button Print on top menu of USPIH program initial window picture 15 Picture 16 shows an example Li Noninvasive automatic blood test by Malykhin A V Setup Parameters F2 Calculate F4 Write F5 Start Print F11 About Picture 15 Initial window of USPIH program Print eala Picture 16 Print preview print window There are buttons at top menu of window picture 16 They allow to e Save a report to a file Print a report Update of software Clean the window Fonts Export to MS Word Export to Open Office Calc Export to Open Office Write Exit from the window 9 Non invasive screening hemogram analyzer function test Usually function test of analyzer shall be proceeded prior to each shift during initial switching on of the de vice as follows tests are carried out in atmosphere pressure 750 mm of mercury column Validity pe riod for tests is 1 year Tests must be done only by manufacturer or representati
55. me vascular regions The combination of these effects exercises a mobilizing and regulatory influence on human organism vegetometabolically ensuring body adjustment to conations by changing the blood flow in inner organs and optimizing cerebral blood flow 108 Testosterone belongs to sex steroids which in fluence secondary sexual characters development pubescence and sexual function 109 Estrogen belongs to sex steroids which influ ence secondary sexual characters development Func tional activity of these hormones is realized through hypothalamic factors somatotropic hormone secretion in particular Its structure reminds of prolactin and pla cental hormone chorionic somatomammotrophin which defines closeness of the biological activity In this relation testosterone estrogens and thyroxin sti mulate somatotropic hormone secretion and with hypercorticonemia they suppress it 110 111 112 Water salt metabolism water distri bution in the body Water among other components of human body plays the most important role being solvent both for organic and nonorganic substances and represents a base for body internal environment Most part of water is included as a compound to intra cellular fluids Extracellular water in its turn is a part of intercellular and intravascular fluids As to Bland s data water distribution in a body in percentage from body weight and in absolute values makes up total body water in women 4
56. mean physical activity done by man taking into account kcal consumption and their recovery in a certain period of time It is con nected with energy storage efficiency due to the fatty acid oxidation and makes up 40 which is close to relevant glycolysis tricarboxylic acid cycle and oxida tive phosphorylation One of the fatty acid oxidation products is hydrogen peroxide with active electrons transported directly to oxygen This reaction is related to hemoglobin ability to bind oxygen and oxygenate tissues To a great extent this process is affected by thyroxin Thyroxin splits oxidation and phosphorylation processes reduces high energy phosphate bond for mation and increases development of heat which dis sipates in the environment Thus oxygen consumption changes per body weight unit Thus one time load time will depend on the splitting of fatty acids being of chain nature and connected with the blood circulation in inner organs 105 Respiratory coefficient is defined by the inter action between oxidative processes and processes involved in lipid peroxidation Great importance is at tached to the platelet activating factor which leads to the aggregation of these cells with serotonin being re leased The latter is a vasoconstrictive agent and a stimulator of unstriated muscle contractions In this connection platelet activating factor affects white blood cells thus stimulating chemotaxis degranulation and aggregati
57. monary residual volume and the worse is the functional state of lungs 44 Maximum air flow is an expiratory air speed The reduction in air flow speed is of fundamental im portance The lower is the speed the higher is pulmo nary residual volume i e there is decrease in the in terrelations between alveolar volume and circulatory blood volume Generally decrease of the air flow is an evidence of the following diseases bronchitis pneu monias lung neoplasms abscesses 45 Tiffeneau s test is a relation between time of the pulmonary circulation and time of the systemic circula tion Tiffeneau s test defines elasticity of the cardiores piratory system The less is Tiffeneau s test the higher is a resistance of the pulmonary circulation Decrease in the Tiffeneau s test is accompanied with increase in the minute pulmonary circulation and decrease in their alveolar surface 46 Fibrinogen It belongs to the acute phase plasma proteins and its level rises in all inflammatory and de structive processes It participates in the blood clotting system Its increase is supplemented with the increase of y globulins and hypoproteinemia 47 Creatinine concentration As to the nature of formation we distinguish between exogenous and en dogenous creatine Endogenous creatine is formed in the process of tissue synthesis Mainly creatine syn thesis occurs in the liver wherefrom it is transported to muscular tissue via bloodstream Here
58. n 0 1 s Depolariza tion and repolarization cycles generate weak electric potentials Atrial depolarization results in small devia tion called P wave 0 2 s delayed This wave is fol lowed by the sharper potential oscillation known as QRS complex It reflects the depolarization of both ventricles After that another component T wave ap pears Temporal relations between these total me chanic events are accompanied with the changes of pressure in left atrium left ventricle and aorta as well as blood flow in aorta during full cardiac cycle 82 Left ventricle contractions In ECG beginning of the left ventricle contraction is signalized by QRS complex At very short interval after depolarization muscle fibers ventricular walls begin developing active tension where contractile elements of myocardial cells known as myofibrils participate Myofibrils con sist of bundles of filaments which in turn form repeat ing chains sarcomeres Because of their contraction pressure in the left ventricle starts rising At this stage aortic valve is still closed since aortic pressure higher than pressure in the left ventricles and mitral valves come closer as the blood flow from atrium to ventricle decreases This status is of short duration since ven tricular pressure promptly exceeds atrial pressure This periods ends with mitral valve closure Ventricular wall tension starts growing very fast and continues growing until ventricular
59. n the myo cardial diseases Elevations in ALT activity is observed in viral hepatitis type A Besides elevation of ALT ac tivity is seen with acute myocardial infarction but this elevation is not so sharp as compared to AST activity Simultaneous determination of these two aminotrans ferases is a very valuable diagnostic test In health AST ALT activity ratio de Ritis coefficient equals to 1 33 0 42 This coefficient reduces in the patients with viral hepatitis and rises in the patients with acute myocardial infarction 23 Amylase is an enzyme that breaks carbohy drates starch etc down into glucose It facilitates glu cose uptake from the blood It is secreted with saliva into oral cavity where it begins to break starch down or with pancreatic juice into duodenum Acid gastric juice inactivates amylase The experiments have shown that after 80 g glucose was administered lase administration ensured that blood sugar indices remained normal 86 of patients with diabetes have a small amount of amylase in their intestinal secretion Being an enzyme produced by pancreas amylase level in the blood and urine rises sharply in the pro gress of pancreatitis 24 Bilirubin is a pigment formed as a result of he moglobin breakdown and to a lesser extent as a result of megaglobin breakdown The determination of total bilirubin and its fractions is very important for the dif ferential diagnostics of jaundice of various eti
60. ncing the flow of liquids i e hydro static pressure occurring in lumen being subject to the heart force The balance between hydrostatic hydro dynamic and oncotic pressures defines the flow of liq uids from vessels to tissues and visa versa 3 Permeability of cell and vascular walls and other membranes It is connected with certain biochemical processes 4 Active biological mechanism of ion migration The systems of active transport maintain transport of sub stances against their concentration gradient with the consumption of macroergic phosphate energy 5 Active regulatory mechanisms which define the level of water and sodium loss in such nodes as the points of contacts between internal and external envi ronment of the organism First of all these are renal regulating mechanism pituitary antidiuretic hormone and aldosterone 89 Systemic circulation time is a time of a full and complete cycle of blood flow through the systemic cir cle vessels related to five factors of the regulation of blood circulation in inner organs These factors are in dissolubly related to the regulation of water electrolytic metabolism 91 Spectral wavelength of absorption in the blood This index characterizes hypocapnia and hy percapnia 92 Spectral wavelength of absorption This index characterizes nitrogen metabolism in the body When it is lowered the destructive processes can be often observed When assessing this index
61. ne person with used norms of all parameters in na ture These parameters were received many years ago in limited study population They are average sta tistical IT IS IMPORTANT Additional parameters help to es timate a patient state more exactly and make a prog nosis for a disease prescribe medicine You can close this panel use keys ALT F2 when you have studied all additional parameters 22 6 To prepare a report for printing please press key F11 When you press the key F11 there will be displayed a window of report editor There is a computer prompt ing of presumptive diagnosis for a doctor at the end of a report A doctor can agree or not with it add or de lete something from it or delete at all print a report without it for patient Print xs AP gt gt IT IS IMPORTANT Please remember only a doctor can diagnose a patient A computer gives a prompting from a list of diagnosis from its memory So a com puter doesn t know all nosology now 22 7 Saving results of diagnostics in file or print copy To save results of diagnostics in file please press the button and save it To print results please press the button Cleaning a report editor x 2 Selection of a font EM Press the button to export results to MS Word The program exports results of diagnostics to MS Word and will start it E Meshir 3 Mic
62. nergetic substrate Conditions for accumulation of some reserve carbohy drates are created due to its ability to deposit in the liver and muscles When energy consumption in creases glycogen usually decomposes Thus this process is accompanied with the increase of function of some endocrine glands thyroid adrenal medulla hypophysis secreting hormones which activate gly cogen decomposition Due to glucose formation glu cocorticoids prevent hepatic glycogen from being de stroyed Thyroid hormone thyroxin facilitates glucose absorption in the intestine Blood glycogen concentra tion increases in hepatolienal syndromes diabetes malignant growths Hereditary diseases with glycogen metabolism disorders hold a special position 102 Used power of life support Average power used for life support is 2300 kcal per 24 hours for man weighing 70 kg Used power of life support is en sured by the changes of free energy with complete combustion of 1 mole palmitic acid making up 2338 kcal High energy phosphate bond is characterized by value 7 6 kcal mole Thus with total oxidation of one palmitic acid molecule it makes up 130 ATP mole cules Being recalculated to kilogram this value changes from 1 to 20 kcal kg min and more It is re lated to arterial blood oxygenation and hemoglobin ability to bind oxygen and oxygenate tissues To a great extent this process is affected by thyroxin Thy roxin splits oxidation and phosphory
63. of lipoprotein complexes Also this value is related to the state of liver gastrointestinal tract and kidneys The oxygenation rate is affected significantly by the temporal relations of blood circulation in the systemic and pulmonary circulation 32 Surface of gaseous exchange It is a erythro cyte respiratory surface which averages 350000 cm 43000 Value of the surface of gaseous exchange varies with the corpuscular volume age weight and Sex 33 Vital lung capacity This is a value representing lung ability to receive blood circulation minute volume which defines alveolar surface area participating in respiration 34 Transportation of oxygen It is a value depend ing on the functional and morphological state of sys temic and pulmonary circulation and first of all on lungs heart liver and gastrointestinal tract 35 Quantity of consumed oxygen per 100 gram brain tissue is associated with a complex cause in volved in the redox processes lipid peroxidation reac tions and with a state of thyroid blood circulation regu lation Thyroid blood circulation determines the trans portation of oxygen and its consumption by inner or gans due to the activation of thyroid hormones T3 and T4 This index depends on the activation or inactiva tion of organ oxygen consumption This value aver ages 2 5 3 5 ml 100 g tissue for adults and 3 5 6 ml 100 g tissue for children 36 Arterial blood oxygenation is rela
64. ogram analyzer and its function 1 1 Purpose of the AMP non invasive screening analyzer The AMP non invasive screening hemogram ana lyzer is medical device which actually is able to define HGB HCT RBC WBC Lymphocytes LYM PLT K Ca total protein TP cholesterol CHOL upon measuring the temperature at certain biologically active points of human body surface using the non invasive method The system has continuously been developed Measuring techniques and the software development will allow further parame ters measurement with accuracy more than the re quired existing ones Results of the non invasive examination are pre liminary giving highlights to more accurate and detailed in vitro examinations results 1 2 Basic principle of AMP device function Function of the AMP analyzer is based on interrela tion of work of the blood circulation system of insides with heat of chemical reaction of Nitrogen Oxygen Hydrogen and Carbon Changes of temperature de termine the activity of chemical elements through inter relation of Nitrogen compounds and Hydrogen bound 9 ing furthermore through interrelation of Oxygen melt ing factor changes The goal of the examinations is determination of changes in composition of blood shaped elements and during the end of chemical reactions which have inter connects with Oxygen consumption and Carbon diox ide exhaust regulated by organism having influence to leve
65. ol l clinical picture of the dis ease is characterized by neuromuscular hyperexcita bility spasmophilia and asthenic feelings 12 Potassium is a cation being presented in the blood plasma in the concentration 4 14 4 56 mmol l Its primary functional purpose is to participate in the neuromuscular conductivity The gastrointestinal tract and kidney play a significant role in the regulation of potassium metabolism Hypokalemia threatens with severe consequences It may be observed in Conn s syndrome and can accompany occasional myoparaly sis combined with migraines epilepsy and progres sive muscular dystrophy Hypokalemia can appear as a result of potassium loss through the gastrointestinal tract and kidneys and due to the diabetic acidosis Hyperkalemia is associated with the cardiac and renal malfunctions 13 Sodium is a primary cation in the blood plasma Its normal value is 130 5 156 6 mmol l Changes in the concentration relate to the changes in plasma spe cific conductivity which normally makes up 0 72 1 Ohm cm Changes to the regulation of sodium in the organism are associated with kidney diseases gastro intestinal disturbances as well as with the impairment of contractility Rise in venous blood pressure causes hydrostatic pressure to increase When hydrostatic pressure is higher than oncotic pressure this can cause electrolytes out of intercellular space This phe nomenon leads to hypovolemia and activate
66. ology The elevation of unconjugated bilirubin level in the blood and tissues is determined with hemolytic jaun dice In hepatocellular jaundice hepatocytes are being destructed conjugated bilirubin excretion into the bile capillaries is impaired and it leaks into blood where its level elevates significantly Moreover ability of the hepatocytes to synthesize bilirubin glucuronides re duces Consequently unconjugated bilirubin level ele vates In obstructive jaundice the biliary excretion is impaired which leads to steep elevation of conjugated bilirubin level 27 The concentration of plasma protein Plasma proteins are divided into three groups albumins globulins and fibrinogen Being colloids proteins bind and hold water preventing its outflow from the blood stream Some plasma proteins fibrinogen in particular are basic components of blood clotting Blood plasma proteins are one of the most important circulatory buff ers which support level of blood cations by forming nondialyzable compounds with them The clinical prac tice has evidenced conditions defined by the change of total plasma proteins Hyperproteinemia is a in crease of total protein concentration in the plasma It is seen with diarrhea vomiting obstruction of the upper small intestine and water loss Hypoproteinemia i e a decrease in the total protein concentration is seen in the patients with neurotic syndrome In addition it oc curs with hepa
67. on and Extract Files Files will be extracted to this folder IC Users a Desktop biolika5 V Show extracted files when complete A folder with program update will open Ow biolikas Organize Favorite Links Name Date modified IE Documents biolika5 10 30 2017 8 27 PM More Folders Start updating There is the detailed description of this process in the part Install the software 23 2 To receive the user manual for the device AMP click on the same icon and save the manual like it is described in part 24 1 3 Load to your computer updating file biolika5 zip Save it to the f RPC BioPromin LTD and start updating 61038 Ukraine Ferte sir sir 4 The updating will be done automatically Start program USPIH 38 097 377 97 87 button Record to index your base data Now you can work as u 40 740 252 112 20 100 595 100 86 139 109 902 62 Arabik Language 375 296 765 494 38 067 44 12345 International centr of information and innovation technologis 12 40 bioluch yahoo com Contact form Update for the program USPIH USER MANUAL for the device AMP VISTA Support Download update Download USER MANUAL VISTA 24 Update GUARDANT key You can update your GUARDANT key yourself You should do the following Open C Program Files USPIH start the GSREMOTE EXE application
68. on of polymorphonuclear leukocytes with them producing superactive radicals Platelet activating factor represents a phospholipid bioregulator and is associated with lipoproteins and high density lipoproteins Thus respiratory coefficient is determined by a combination of biochemical processes set forth in clauses 102 103 above 106 Tyrosine Thyroid hormones thyroxin and triio dothyronine are iodated tyrosine derivatives Tyrosine is present in food and in the body in high volume Due to the influence of pituitary thyrotrophic hormone on thyroid proteolytic enzyme are activated which re lease thyroxin and triiodothyronine form the bond with thyreoglobulin molecules The primary points of thy roxin application in tissues are cytomembranes nuclei and enzymes of the biological oxidation system Thy roxin increases generation of heat which dissipates in the environment Triiodothyronine increases oxygen consumption by the tissues heart in particular Con currently there is a change in heat generation degree which is defined by catecholamine deficiency 107 Cerebral blood flow Regulation of the cerebral blood flow per 100 g tissue is determined by the inte raction of extra and intracranial factors Among extra cranial factors are atmospheric pressure gas composition of air partial gas pressure in the atmos phere wavelength of Xe86 These factors affect chemoreceptors baroreceptors photoreceptors pres sure receptors
69. pressure exceeds aortal pres sure Once ventricular pressure is higher than aortal one a system of forces occurs which opens aortal valve Blood percentage driven out of the heart during blood expulsion is characterized by the left ventricle contraction capacity Cardiac output is a part of minute volume of blood being pumped by heart as a result of heartbeat The cardiac output value is influenced by the intensity of myocardial contractions pressure in the pulmonary circulation de Ritis coefficient aspar tate transaminase activity and triiodothyronine and tetraiodothyronine activity 83 84 Arterial pressure Speaking of blood pres sure we always mean pressure measured relative to the atmospheric pressure Usually it is taken that pressure in the body tissues directly near outer arterial walls is equal to the atmospheric pressure so blood pressure is considered as transmural pressure trans mural pressure represents difference between inner ip and outer op pressures where ip is a pressure inside artery and op is an outer pressure equal to the atmospheric pressure Arterial pressure generation is controlled by rennin angiotensin system and kinins bradykinin hormones of adrenal zona glomerulosa layer participating in the regulation of sodium and po tassium electrolyte metabolism The main hormone regulating mineral sodium and potassium metabolism is aldosterone In addition arterial pressure generation is influen
70. ress the button Browse and specify a path to file if Guardant dongles remote programming _ Select the format of software vendor s answer file or hexadecimal number Enter the data into corresponding field and press Next gt Press the button Next Select the format of software vendor s answer file or hexadecimal number Enter the data into corresponding field and press Next gt You have received an answer file enter the file path into the field or press Browse to select the file C Users a Desktop vemote Browse You have received a hexadecimal number answer enter the number into the field If you see the following window your GUARDANT key is successfully updated Press the button Finish Ea Guardant dongles remote programming x Dongle memory contents have been successfully updated Press Finish to exit the program Dongle memory contents have been successfully up dated You can buy a version of the device without examina tion accounting 25 Possible problems and troubles 25 1 Problem After installation the program USPIH program doesn t work Solution a Please check whether key Guardant Stealth II connect with computer through USB port b There should be light inside your key there is a LED inside If there is no light you didn t install the driver for Guardan
71. rosoft Word be 3g 81 215 8 319 ai tree B Program USPIH Mashir 3 6 20 2009 1 32 15 PM Noninvasive hemogram analyzer AMP Name Mashir 3 Sex 1 Age 67 Weight 98 PS 76 BF 18 33 414 33 530 6979 33 720 168 0160 746 33 232 No Characteristic Nom Value Blood formula Hemoglobin HGB g1 120 175 148 924 Erythrocytes RBC 10 121 1mm3 4 5 6 4 619 Lymphocytes 96 1937 17 122 Leukocytes WBC El0xpi 43 113 7 298 Segmented neutrofiles 47 72 66 320 Erythrocyte sedimentation rate ESR mm h 1 14 3 626 Eosinophils 0 5 5 8 2 277 Monocytes 3 11 8 005 Stab neutrofiles 1 6 6 276 Calcium Ca in plasma mmol 2253 2 443 Magnesium Mg in plasma mmol 07 099 0971 Potassium in plasma mmol 34853 3 798 Sodium Na in plasma mmol 1 1305 1566 141 842 3 5 12 Kon 20 Press the button to export results to the Open Office Writer The program exports results of diagnos tics to the Open Office Writer and will start it 3 odt OpenOffice org Writer File Edit View Insert Format Table Tools Window 2 862 02 6 9 t fd Header m TimesNewRoman e 2 Program USPIH Mashir 3 6 20 2009 1 32 15 Noninvasive
72. s TG 85 of which being split in the gastrointestinal tract 5 TG splitting in the stomach leads to the formation of free fatty acids which are released to the intestine where under the influence of steapsin fatty acids TG split to monoglycerides This process is regulated by entero statin gastrointestinal hormone initiating a sensa tion of fullness during food intake and digestion Fatty acid oxidation 53 Cholesterol Conditionally we can distinguish three cholesterol pools in a human organism pool A rapidly exchanging 30 g FC free cholesterol pool B slowly exchanging ca 500 g FC and very slowly exchanging ca 50 g FC Experimental data showed that 6 mg cholesterol accounts for 1 g body weight Major portion of nonestherificated cholesterol NEFC occurs in cell membranes and myelin sheathes containing phospholipids In plasma mem brane molar correlation of NEFC with phospholipids is equal to 1 Cholesterol synthesis occurs in almost all cells and tissues however it is produced considerably in the liver 80 and in the small intestine walls 5 As a first approximation cholesterol biosynthesis can be divided into three stages 1 Mevalonic acid biosynthesis 2 Squalen formation from mevalonic acid 3 Squalen cyclization and cholesterol formation The main source of mevalonic acid formation in the liver is acetyl coenzyme A and in the muscular tissue it is lycine C
73. s cleaning of analyzer dail chapter 12 para 1 2 y periodic inspection _ by manufacturer repair Warranty and other repair is provided by ONKOCET Ltd Sreznevskeho 17 831 03 Bratislava SLOVAKIA Tel Fax 421 2 44640977 e mail onkocet gmail com www onkocet eu Warranty repair of PC is provided by dealer 13 Search of fault and elimination of faults Analyzer is an accurate measuring device repair of that is to be provided by manufacturer or its local rep resentative Chart 4 contains possible faults requiring presence of manufacturer or its representative Chart 4 Search of faults and elimination of faults Possible rea Elimination of Fault ne piaced not Check up place There is a dis properly on ment of sensors as turbing signal on one or more sensor body it tight enough 2 Disruption of one or more ca bles Contact represen tative of manufac turer No data col lection during examination Disruption of analyzer usb cable or con nection fault of socket Check up usb ca ble and sockets 14 Periodic inspection of non invasive screening analyser Periodic inspection of the non invasive screening hemogram analyzer is to be made annually after its use or storage Manufacturer provides inspection de scribed below during manufacturing and annually and after repair Chart 5 Devices used during periodic annual in sp
74. s juxtag lomerular apparatus of kidneys This results in stimula tion of the adrenal cortex and increase in aldosterone secretion In a whole these factor combinations give rise to the organotrophic disorder All these factors bring on changes in the diurnal diuresis The system of blood fibrillation 14 15 16 17 The most important factors of this sys tem are plasma kinins Practically they form kinin sys tem which supports regulation of the local and general blood circulation as well as vascular permeability The main mechanisms are interactions between plasma kallikreins and tissue kallekreins of pancreas salivary glands kidneys and intestinal wall As the final result this interaction leads to the beginning and to the end of blood fibrillation It is observed that there should be an interval exceeding 30 seconds between the begin ning and the end of blood fibrillation The platelets containing arachidonic acid play an important role in the formation of this time interval Haematocrite is of considerable importance in the formation of interval between the beginning and the end of blood fibrillation The fermentative system 18 19 20 21 22 AST and ALT are enzymes catalyz ing intermolecular amino group transfer between amino acids and keto acids As a result of the interac tion between these transferases oxaloacetic pyruvic and glutamic acids Elevations of aminotransferase activity especially of AST are observed i
75. smic reticulum ribosomes of hepa tocytes Latest data showed that VLDLP assembly is greatly influenced by microsomal TG carrying protein 57 In bloodstream CM and VLDLP make contact with the lipid components of membranes of red cells weight cells endotheliocytes and other cells These contacts are exposed to the lipolytic enzymes This exposure leads to the delipidization and partial depro teinization It is illustratory that after being formed remnant particles of CM and VLDLP continue enrich ing itself in apo E through its transition from VLDLP 58 Rich in cholesterol VLDLP Protein component is presented by apoproteins B C E Approximately of total protein of these LP accounts for apo B In a cer tain manner molecular and immunochemical hetero geneity of VLDLP is connected with atherogenesis and can serve as a additional criterion of its evaluation Carbon dioxide transportation and consumption 59 CO release is indissolubly related to the oxygen consumption and CO generation in organism is generated in organism as a result of biochemical transformations of glucose amino acids fats in the liv er and blood under the influence of enzymes Since glucose is one of the main oxygen source for a cell its level is connected with generation and release in organism Under the influence of glucose oxydase glucose is oxidized by air oxygen to gluconic acid and hydrogen peroxide in equimolecular quantit
76. ssing is completed examination data ap pear automatically on the screen picture 6 Hemoglobin 138 98 Erythrocytes 4 17 Lymphocyte 25 09 LeucocytesT 32 Plasma Ca concentration 2 44 Plasma Na Plasma conc Thrombocytes 264 t Haematocrit Plasma albumen Cholesterol Picture 6 Examination results window Examination data calculated by PC are saved auto matically 6 9 Remove sensors from the patients body 6 10 Results of examination can be printed out by Print menu pictures 7 and 8 Setup Parameters F2 Calculate F4 Write F5 Start Print Fll About Picture 7 Printing the examination data after preview of results on picture 8 gt Diagnostic abiities of multifunctional complex jomatic noninvasive method of determination of blood Malykhin Pulavskyi teeeeeeeseeseessee 17 06 2007 16 29 19 zzz TEST Sex 1 Age 77 Weight77 Breath req 18 Pulse 77 750 33 46 3 3 Blood formula 1 Hemoglobin HGB 138 96 gl 2 Erythrocytes RBC 447 1mm3 3 Lymphocytes 2309 4 Leukocytes WBC 9 4310 9 4 Leukocytes WBC 9 4310E3 mkL 5 Segmented neutrofies 5772 6 Erythrocyte sedimentation rate ESR 4 26 mm h 7 Eosinophiis 079 8 Monocytes 968 9 Stab neutrofies 81 Electrolyte metabolism 10 Calcium Ca in plasma norm 2 25 3 0 2 44
77. t 2007 06 20 Budapest 2008 11 07 ORKI A4163 Eg szs g gyi Min s gfejleszt si s K rh ztechnikai Int zet Institute for Medical Quality Improvement and Hospital Engineering El z n v Orvos s K rh ztechnikai Int zet Tel 36 1 356 1522 ORKI Institute for Medical and hospital Engineering Fax 36 1 375 7253 Di s rok 3 H 1125 Budapest Internet www orki hu
78. t Stealth Il Please install it You should check whether the driver for Guardant Stealth II was installed right Open the Control Panel Connect To Default Programs All Programs Help and Support Run the System Name Category Adobe Gamma Wb Backup and Restore Center BitLocker Drive Encryption 5 Date and Time d Device Manager E Folder Options 9 Game Controllers indexing Options iSCSI Initiator Mouse B Offline Files Pen and Input Devices Wi Performance Information and Tools E Printers A Programs and Features Scanners and Cameras Sound Sync Center EP ne cll AutoPlay Administrator Ei Color Management Default Programs Ease of Access Center Fonts Guardant drivers Internet Options Keyboard 55 Network and Sharing Center amp Parental Controls People Near Personalization 9 Power Options 1 Problem Reports and Solutions 9 Regional and Language Options Security Center Select Advanced system settings 82 Control Panel System Tasks View basic information about yol Device Manager Windows edition Remote settings Windows Vista Ultimate Copyright 2006 Microsoft Corporatic 9 System protection y Advanced system settings Select Hardware and Device Manager Device Manag
79. ted to hemo globin ability to bind oxygen and oxygenate tissues To a great extent this process is affected by thyroxin Thyroxin splits oxidation and phosphorylation proc esses reduces high energy phosphate bond formation and increases development of heat which dissipates in the environment Oxygenation curve is connected with atmospheric pressure blood pressure and active site temperature 37 Cardiac output is a part of minute volume of blood being pumped by heart as a result of heartbeat The cardiac output value is influenced by the intensity of myocardial contractions pressure in the pulmonary circulation de Ritis coefficient aspartate transaminase activity and regulation state of the creatinine kinin sys tem 38 Oxygen consumption per kilogram weight This dimension is attributed to the triiodothyronine ac tivity We can arrange organs in descending order in respect of triiodothyronine influence on the oxygen consumption per kilogram body weight as follows heart 10 11 gastric mucosa liver smooth mus cles 4 5 kidneys 1 diaphragm 4 39 Pulmonary ventilation is a correlation between entering air volume and exiting air volume per minute The pulmonary ventilation average depends on sex age and weight and makes up 8 10 l min for a person weighing 70 kg 40 O2 consumption per minute is related with the state of pulmonary circulation systemic circulation liver kidneys and gastrointestinal tract
80. th Windows Vista XP 2000 2003 or equal or higher level software 6 Examination of non invasive screening blood test and metabolite test and indication of calcula tion results Blood test and metabolite parameters definition are to be made in following sequence 6 1 Connect patients cable to socket of analyzer and fix it by screws analyzer gets mains power from PC therefore it is out of voltage 6 2 Connect USB cable supplied with PC to analyzer and USB port of PC 6 3 Switch on the PC 6 4 Clicking to icon on the screen run the USPIH soft ware 6 5 Place sensors onto patient 6 6 Load demographic and physiologic data of patient by means of keyboard of PC in sequence shown below hospital class is not obligatory Name Surname Sex Weight Pulse rate Breath rate as it shown on picture 3 TEST Sex ho Age wo Weight Puls rs Breath Freq s Picture 3 Data entry of patient 6 7 Click to calculation time sequence picture 4 C 180 intervals 360 intervals C 720 intervals Picture 4 Calculation time sequence entry 6 8 Click by mouse at upper menu to Start or run the processing program by F9 picture 5 Li Noninvasive automatic blood test by Malykhin A V Setup Parameters F2 Calculate FJ Write F5 Start Print F11 About Picture 5 start of the data processing program When proce
81. the previous session Otherwise select Create number question to start new update session Process number answer received from software vendor Press the button Copy and send a number question to e mail which you find http www analizator amp com ua en or send it to ICQ 259 030 294 in following example the number question is 5693DD68C040B89EEA88D73ECB5FCA 4F7B165FC73FFA81FDFF9064032C9E138E Press the button Next You have now generated the number question that is to be forwarded to vendor of your protected software You can use the phone e mail or other communication medium for this purpose 5693DD68C040B83EEA88D 73ECB5FCA4F 7B 165FC73F 81 064032 9 138 After you have memorized the number question you may exit the program and continue the update session upon receiving the number answer from the software vendor Press Finish if you wish to exit the program If you are sure to receive the answer immediately press Next gt to continue update session now Press the button Next Please consult the software vendor as to the mode of updating dongle s memory contents in whole or in part pdate whole memory contents of the dongle you Update a part of memory contents of the dongle you have received the answer file or hexadecimal number answer You will receive by e mail an updated file re mote upd You should p
82. the cell Blood is a part of body internal environment with well defined concentration of the transported substances Hydrogen ion concentration is a very important constant defining full value of the metabolic transformation in cell which determines body need in working systems aimed at supporting constant hydrogen ion concentration by the excretion of redundant hydrogen ions or their retention in case of deficit This mechanism is supported by buffer sys tems The most powerful blood buffer is proteins he moglobin in particular Hydrogen ion concentration is regulated by bicarbonate buffer consisting of carbon dioxide and sodium bicarbonate Another buffer is a phosphate one Mono substituted phosphate serves as an acid and twice substituted phosphate serves as a salt Phosphate buffer is closely related to bicarbon ate and protein buffer systems with kidneys support ing decrease or increase of bicarbonate level when pH changes The main mechanism of supporting concen tration of hydrogen ions represented in renal tubule cells is a process of sodium reabsorption and hydro gen ion secretion 97 Glutamic acid is an amino acid which regulates metabolic processes and affects ion concentration sodium potassium etc Required sodium ion con centration in the body is supported by formation of ammonia in the kidneys and its use for neutralizing ac id equivalents and their renal excretion Resulting free ammonia easily penetr
83. tinine phos phate to ADP Creatinine phosphokinase acts in a dual manner in the muscular tissue in sarcoplasm enzyme transports phosphoryl group from ATP to creatine re sulting creatinine phosphate is used for phos phorylirazing ADP which is combined with myosin in myofibrils This system along with sodium and potas sium and stimulated ATPase participates in energy supply to the active ion transportation through cell membranes 100 Creatinine kinase in heart is divided in three types 1 Isoenzyme 1 BB characterized by high mobility attributed to the temperature changes mainly in the abdominal region 2 Isoenzyme 111 MM moves at a lower speed 3 Isoenzyme 11 MB in between position as to mo bility Heart contains mainly MM and MB forms It is as sumed that energy of the transport from mitochondrion to cytoplasm of myocardial cell is transferred through the internal mitochondrial membrane In intermembra nous space Mg2 occurrence a balance is being es tablished between ATP Mg2 and Mg2 complex at the outer side of internal membrane A considerable increase of CFK is seen with muscu loskeletal disorder and in acute myocardial infarction Thus CFK activity increases earlier than activity of other enzymes High CFK activity is observed in vari ous central nervous system diseases schizophrenia manic depressive psychosis syndromes induced by psychotropic agents 101 Glycogen is a reserve e
84. tocytic lesions and with the disorder of renal filter lipoid nephrosis Generally we may relate hyperproteinemia to hyperglobulinemia and hypopro teinemia to hypoalbuminemia Oxygen consumption and transportation 28 Plasma density The plasma density is defined by total amount of plasma cations and anions 1048 1055 g cm3 is a norm Changes in the plasma density are attributed to the disorders of water metabolism These processes are greatly effected by antidiuretic hormone It can be seen with Conn s syndrome which is associated with the changes in aldosterone level When plasma density is lower 1056 this results in blood pressure instability hypodynamia sometimes convulsions 29 Circulatory blood volume The volume of circu latory blood is a genetic value and makes up 68 70 ml kg for men and 65 69 ml kg for women The changes of these values are attributed to water and electrolyte imbalance as well as to the diseases of in testinal tract and kidneys 30 The minute volume of circulatory blood This is a value resulting from the functional state of organ ism and is connected with respiratory rate and heart rate The average values calculated for a person weighing 70 kg are 4 4 5 ml min 31 Oxygenation rate It is a rate of oxidative proc esses taking place in erythrocyte and in the cells This value is formed under the influence of lipid peroxida tion which defines permeability of cell membranes composed
85. uscular activity Rise of the lactic acid concentration can be seen with hypoxia cardiac pulmonary insufficiency anaemias neo plasms acute hepatitis terminal hepatocirrhosis toxi coses Thus increase in the lactic acid concentration in blood is attributed to increase of its production in the muscles and to the decreased ability of liver to trans form it to glucose and glycogen 50 Urea All parts of residual nitrogen represent final products of protein metabolism Concurrently the main final product of protein metabolism is a urea Ammonia is the primary source of urea formation Urea level shifts depend on the process of urea formation and its excretion These processes are interconnected with metabolism of amino acids arginine and glutamine The level of blood urea is decreased in hepatocirrho ses acute yellow atrophy phosphorous arsenical and other poisoning affecting liver In general increase of the urea concentration is accompanied with increase of creatinine and filtration reduction 51 Glucose is the most important blood component Its concentration reflects status of carbohydrate me tabolism Glucose is distributed almost equally be tween plasma and formed elements of blood Blood sugar concentration changes with age Sugar concen tration in newborns is the same as sugar concentration in their mothers After birth sugar concentration is de creased rapidly and makes up 65 4 30 mg By the age of 5 6 days
86. ve company 9 1 Connect patients cable to socket DB9 of analyzer and fix it by screws 9 2 Connect USB cable to analyzer and to PC 9 3 Switch on the PC 9 4 Run USPIH software by clicking to its icon 9 5 Place sensors into vessel with glycerin at 33 C as it shown at picture 17 Check the temperature of the glycerin by common gauge Picture 17 Placement of the sensors during function test of analyzer 9 6 Fill in the data fields of patient name sex age weight pulse rate breathing rate as it shown at picture 18 L Noninvasive automatic blood test by Malykhin A V o E Setup Peremeters F2 Calculate F4 Write F5 Stert FB Print About N Hemoglobin Remark Erythrocytes 4 Name zzz TEST Lymphocyte Sex 1 Leucocytes Plasma Na conc Plasma K conc Puls 77 Thrombocytes Ith Fre 18 Haematocrit Plasma albumen Cholesterol wm IND 3 agnose ver 6 52 LPV eo _ gt 00 00 Sus 50 50 Picture 18 Data sheet of patient 9 7 Click on Start menu at upper tool menu of USPIH program Label of the button will change to Stop In field of program running progress under upper menu growing numbers will appear 0 100 and in accordance with examination sequence 180 sec 360 sec 720 sec red green or blue bends will appear filling up from left to right When the time se
87. ygen become hy drogen bonded At a phase transition temperature phospholipids pass from a solid gel to a liquidcrystal state Molecular nature of phase transition is attributed to the changes of average speed of oxygen supply depending in the temperature In special literature when assessing cholesterol role the membrane structure and function it is considered that cholesterol facilitates decrease in mobility of fatty acid chains at high temperatures and increase in mobility at low tem peratures 116 Oddi s sphincter basal pressure determines hemodynamic effect ensuring resynthesis of the intes tinal wall lipids According to the present day ideas triglyceride resynthesis occurs in the epithelial cells of small intestine villi Triglycerides are the most high calorie substances At their complete oxidation energy output makes up 9 5 kcal Quantity of energy stored in 1 g such free of liquid fat as triglycerides is six times as large as quantity of energy stored in 1 g glycogen In other words if calories were deposited in human body in the form of glycogens than in order to accu mulate 128000 kcal one may rather need 13 5 g triglycerides than 80 kg glycogens It is Oddi s sphinc ter basal pressure that provides daily caloric require ment of man through switching and regulation of fat and carbohydrate metabolism 117 Prothrombin index is connected with platelet activating factor The latter belongs to the lipi
88. ystem Function of the system is provided by program of the central processing unit of analyzer and software loaded to PC in time sequences set by operator 180 s 360 s or 720 s Connection of the analyzer to PC in working condition is indicated by LED on the front panel Software installed on PC provides indication of fol lowing modes e Calculation time sequence e Connection of non invasive screening hemo gram analyzer to PC via virtual serial port e Proceeding of calculation process time se quence readiness e Indication of errors in software and analyzer on windows on screen with information about cause and way of elimination e Printing out the results of examination e Saving the data to database recall and print out when necessary 5 Software packet USPIH installation software is supplied on CD with the equipment Prior to use the analyze it is necessary to install the software to PC During installation new directory appears on hard drive containing following files C Program Files USPIH biolika5 exe real time control program biopromin doc licence agreement for software USPIH EN chm help pacient db pacient px database files confdbe ini database configuration file qtinf dll function file FTDI directories PC interface drivers files Other files necessary for operation of interface drive USPIH software can be used with PC II and higher running wi

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