The First Single Use Bioreactor
Contents
1. aaa 056 0251208 UniSpense OmniSpense and WHEATON are registered trademarks of WHEATON Industries Inc Because it s my life s work and R2P are trademarks of WHEATON Industries Inc Microsoft Windows and Vista are either registered trademarks or trademarks of Microsoft Corporation in the United States and or other countries Pentium is a trademark of Intel Corporation in the U S and or other countries Modbus Protocol is a registered trademark of Schneider Electric S A or its subsidiaries in the U S and or certain other countries Copyright 2012 WHEATON Industries Inc Printed in USA WPDL_002A_rev1 01 20142. ATON systems or unsupported systems Maintenance free brushless DC motors for years of trouble free operation WHEATON has a long history of designing building and supporting cultivation equipment The R2P 2 0 and the WHEATON Standard Roller are the next logical steps WHEATON R2P 2 0 Roller Apparatus for Adherent Cell Culture Available in Top or Bottom Mounted Countrol Robust touch screen interface that is easy to view from a distance m Readily recognized icons for intuitive navigation a Digitally controlled maintenance free motor accurate to 0 01 RPM m Capable of remote control and monitoring through SCADA systems Multiple decking and capacity configurations available for process flexibility USB Downloadable System Event Log Specifications CCI AG AE E E E E E A EE E 5 88 Positions Bottle Speed 110mm Diameter Bottle other speeds available 0 25 8 1 RPM PC WA ee ccsecire te ecete bance A 0 01 RPM DAVE aaen petted E cas eae anrancceenbafotscanaanaticens Belt Driven Motor TYPE iarrann anann aa aaa AANER ten Brushless DC Rotation Direction ecn Clockwise Counter Clockwise and Rocking Belt Break Alah mesrinpnrnienei a e e ERE Included Modbus Protocol and WHEATON Protocol via Ethernet TCP IP and RS422 485 O aa N 80 up to 31 C PSPUAE TEMPE soene ee uoynoncantees 10 to 40 C INETI OERE AEAEE E T 100 240 VAC 50 60 Hz 35W Say Goodbye to Quick Start Cards and User Ma
3. E T Belt Driven LOC a 0 E E E E OE Brushless DC ROTATION DINGCTIONS oriai Clockwise and Counter Clockwise Qpt ONSi nn Belt Break Alarm and Battery Backup Remote COMMUN CAt ON ns Dry Contact Relay Alarm wia aie A E EEEE E E E E E E 80 up to 31 C Operating Temperature scccssssecesssscssssscrssessvsscrsvsssrsssssesessresersses 10 to 40 C ee ee ee 100 240 VAC 50 60 Hz 35W Complimentary WHEATON Products Peristaltic Pumps Silicone Tubing Incubators Vented Caps Roller Bottles e Bench Top Rollers Peristaltic Pumps UniSpense PRO OmniSpense ELITE Silicone Tubing Micro Cassette Platinum Cured Peroxide Cured r B E if 7 Incubators Vented Caps Standard amp CO s S Roller Bottles Bench Top Roller WHEATON 800 225 1437 U S amp Canada Only 856 825 1100 856 825 1368 F www wheaton com The First Single Use Bioreactor Monitoring Software CART2 Control Monitor and Recording Software CART Screen CART2 and View Log Software with the Network Interface Network Interface is a single line network adapter for up to 255 R2P units Cat No Plug Style Voltage Qty Case W348902 A North America 120 VAC 1 W348902 B Japan 100 VAC 1 W348902 C Continental Europe 230 VAC 1 W348902 D United Kingdom 230 VAC 1 W348902 F Australia China 240 VAC 1 W348902 G Italy Chile 230 VAC 1 W348902 J India 230 VAC 1 WHEATON 800 225 1437 U
4. S amp Canada Only Remotely monitors and controls up to 255 R2P and R2P 2 0 rollers Records all settings changes alarms and communication loss Password protected user levels maintain security Can be easily added to R2P and R2P 2 0 at any time Conforms to UL CSA and CE Laboratory Standards The WHEATON CART2 System precisely controls rotating speeds of up to 255 separate roller units Each unit is monitored for rotation speed deviation and communication This system provides the perfect solution for GMP or FDA requirements Computer Requirements d He 2 IBM Pentium PC or compatible 32 MB of RAM minimum Microsoft Windows 2000 XP Vista 7 One free serial port 10 MB of free hard drive space minimum 856 825 1100 856 825 1368 F www wheaton com The First Single Use Bioreactor Roller Options Information Belt Break peal ae sl R2P 2 0 The Belt Break 0 sensors to ensure that all main pulleys a are Pae on the unit This is included on all R2P 2 0 Roller Apparatus Deck Kit sala gead The B te in asport processing and power outages The unit e sit ae switches over to battery power to provide rotation for 12 24 hours Bottom mounted control systems house larger longer lasting batteries O l The deck kit is designed for modular systems with removable decks Temperature Monitoring Alarm Option Modular systems have 7 125 deck spacing for easy removal and R2P 2 0 Sa replacement of bottle
5. WHEATON Roller Apparatus R2P 2 0 and the WHEATON Standard Roller for Adherent Cell Culture The First Single Use Bioreactor www wheaton com WHEATON Roller Apparatus R2P 2 0 and the WHEATON Standard Roller LEUT TUZ Tig ie i va wl ToD Pena TIM for Adherent Cell Culture The First Single Use Bioreactor We have updated and enhanced our process control systems for our production scale roller apparatus We understand the importance of our culture systems to the vaccine and biologics industries therefore customer input was a key driver governing the upgrades The systems utilize current technology to facilitate implementation into new production installations with networked equipment The systems also maintain backwards compatibility for existing operations This effort will also enable better control and monitoring for research or pilot roller culture installations The new roller apparatus feature A color touch screen or digital display s An icon driven interface with intuitive menus m The surface mount gold plated electrical connections for better reliability in high temperature environments m Updated industry standard networking commun ications protocols and connections m Lower power consumption for longer battery run time and a safer design a Backwards compatibility for continuing support of existing installations a Retrofit kits available to update older WHE
6. cement areas per deck allows for use with an upright incubator Positions Per Deck 8 5 Eight place is used for large scale production type installations 8 01 11 Number of Decks No of Decks Modular spaced units have a maximum of 9 decks production spaced 01 11 units have a maximum of 11 decks Options 0 No Options Included Options Mount for 0 wae Belt Guard L Options Included WHEATON Standard Roller options include belt break alarm and battery backup R2P 2 0 options include temperature monitoring and alarms 2 probes and battery backup Belt break alarm included in base offering Roller Belts N Main Belt Drive WHEATON 800 225 1437 U S amp Canada Only 856 825 1100 856 825 1368 F www wheaton com The First Single Use Bioreactor WHEATON Standard Roller Apparatus Product Specifications Standard Roller Smooth ramping digitally controlled rotation accurate to 0 1 RPM Maintenance free precision brushless motor Bright digital display for easy operation Multiple decking and capacity configurations available for process flexibility Specifications NOE AAO A EE E 5 88 Positions Bottle Speed 110mm Diameter Bottle other speeds available 0 25 8 1 RPM Pote DAMCI encis N er E E 108 121mm Bottle Length csscecriea sahaceneah sist th titre nedteeccunehteccnsnenrteadementtiaec iis Up to 550mm PG AAC Y me A besecrsenndadad acicl 0 1 RPM Ve PEE A EE EEEE trans E E T E A EE
7. dation Reduction of Loss Potential Width in cm Depth in cm Height in cm Weight TA Control System of Bottle Positions Part Number Positions Decks Bottom Drive Production Spacing WRBPR5010 A 5 1 31 79 25 603 14 35 92 24 5 R2P 2 0 WRBPR5030 A 5 3 31 79 25 63 26 65 85 39 15 R2P 2 0 WRBPF5110 A 5 11 31 79 25 63 74 187 217 99 55 R2P 2 0 WRBPF8110 A 8 11 47 120 25 63 74 187 360 167 88 R2P 2 0 Bottom Drive Modular Spacing WRBMR5010 A 5 1 30 76 20 63 14 34 70 32 5 R2P 2 0 WSBMR501 0 A 5 1 30 76 25 63 14 34 70 32 5 Standard WRBMR5030 A 5 3 30 76 25 63 29 74 112 51 15 R2P 2 0 WSBMR5030 A 5 3 30 76 25 63 29 74 112 51 15 Standard WRBMR5070 A 5 7 30 76 25 63 57 145 196 89 35 R2P 2 0 WSBMR5070 A 5 7 30 76 25 63 57 145 196 89 35 Standard WRBMR5090 A 5 9 30 76 25 63 71 179 238 108 45 R2P 2 0 WSBMR5090 A 5 9 30 76 25 63 71 179 238 108 45 Standard Top Drive Production Spacing WRTPF5110 A 5 11 31 79 25 63 75 190 250 113 52 R2P 2 0 WSTPF5110 A 5 11 31 79 25 63 75 190 250 113 52 Standard WRTPF8110 A 8 11 47 120 25 63 75 190 350 159 85 R2P 2 0 WSTPF8110 A 8 11 47 120 25 63 75 190 350 159 85 Standard The First Single Use Bioreactor Configuration Matrix for Easy Ordering Ordering Information WHEATON specializes in standard and customized roller apparatus units The part numbering system below allows for the configuration
8. nuals The R2P 2 0 touch screen was designed for use directly out of the box There are four types of screens for system navigation The Main Screen displays all of the most important process conditions including bottle speed bottle direction alarms unit identification number power status and the network status From the main screen the user can access the general Setup Screen a e e e e e e e e e m Profile The user can configure system parameters that are frequently accessed from the Setup Screen including speed ramp time and the event log All parameters are changed in Configuration Screens that feature large numeric keypads and intuitive operation The Setup Screen also allows access to the Factory Screen for system parameters that are established during factory assembly and testing All screens can access an onboard user guide that details the function of each Icon Don t worry we will still include the user manual you may just never need it WHEATON R2P 2 0 Main Screen WHEATON R 2P 2 0 Bottle Speed Factory Setup WHEATON 800 225 1437 U S amp Canada Only 856 825 1100 856 825 1368 F www wheaton com WHEATON R2P 2 0 Roller Apparatus and the Standard Roller Select the Control System Low Consumable Cost Configure the Decks Easily Scalable Process Automation Capabilities DACRE Capacity Low Capital Select the Investment Options Easy to Operate Reduced Cleaning Vali
9. of a standard system The main components that make up a unit include the control system the size and type of roller bottle decks and system options There is also a table listing the most commonly manufactured roller apparatus If you have any questions about custom bottle sizes rotation speeds or standard systems please contact your WHEATON Representative Example W R T P F 5 11 1 A Control System R2P 2 0 Advanced touch screen with Control System Type remote communications and alarms R R2P 20 STANDARD S Standard Digitial display Top Mounted Ideal design for rigorous cleaning Control System Location and ceiling mounted mounted connections T Top Mounted Bottom Mounted B Bottom Mounted Ideal design for easy access and floor mounted connections Decks Production 6 152mm Smaller spacing between decks to Spacing allow for more bottles per area P Production Modular 7 125 181mm M Modular Larger spacing between decks to allow easier removal and replacement of bottles Plug Style A North America 120 VAC B Japan 100 VAC C Continental Europe 230 VAC D United Kingdom 230 VAC F Australia China 240 VAC G Italy Chile 230 VAC J India 230 VAC Fixed Fixed size with single piece uprights used for Deck Type production and lighter weight due to less hardware F Fixed Removable R Removable Removable decks for flexible design Back of Unit Capacity 5 Five pla
10. s These are kits designed for customer installation This option includes tw cis emperature probes for real time temperature monitoring an sevigiion alarms The temperature is displayed in the temperature calibration screen or on the screen saver for quick confirmation of optimal operating conditions The deck kit is designed for production systems with removable decks Production systems have 6 deck spacing to maximize system capacity These are kits designed for customer installation Cat No Description W348890V2 WHEATON Standard Roller Top Drive System Options with Belt Break Alarm and Battery Backup W348891V2 WHEATON Standard Roller Bottom Drive System Options with Belt Break Alarm and Battery Backup W348892V2 R2P 2 0 Roller Top Drive System Options with Battery Backup and Temperature Sensors Belt Break Alarm is already included with unit W348893V2 R2P 2 0 Roller Bottom Drive System Options with Battery Backup and Temperature Sensors Belt Break Alarm is already included with unit W348887 Deck Installation Kit for Modular 7 125 Spaced System Units have a maximum capacity of 9 decks W348889 Deck Installation Kit for Production 6 Spaced System Units have a maximum capacity of 11 decks gt WHEATON m L m 1501 North 10th Street Millville New Jersey 08332 2038 USA i www wheaton com USA 2 Canada ae 800 225 1437 m miematono Or aa een an eee 236 8291100 Wondwide Farse ea a
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