Nevus Analyzer TiVi102 User Manual
Contents
1. ______ r Reference Photo Click on the Reference Spot red square in the Actual Photo 11 The reference spot largest spot is now indicated by a red square in the Reference Photo Click on the corresponding spot in the Actual photo to synchronize the two photos TiVi102 Nevus Analyzer 1 1 Sida 19 TiVi102 Nevus Analyzer Actual Photo Reference Photo Mask Remove small objects or click Show Plot Remove Small Objects em r CtsSsS Enumerate Show Plot 12 Print 100 in the Remove Small Objects edit box to remove small objects O x Reference Photo Controls Mask Remove Small Objects Click Show Plot EE Enumerate Show Plot 13 Click the Show Plot button to display the Plot 102 window The Diagram in the Plot102 window displays the relationship between spot sizes in the Reference Photo and the Actual Photo Observe that one spot has a substantially higher value in the Actual Photo than in the Reference Photo as indicated by the red dot in the Diagram TiVi102 Nevus Analyzer 1 1 Sida 20 TiVi102 Nevus Analyzer w D lt a 5 re O lt 1000 Reference Area Display Filename Actual act 0002 jpo Filename Reference ref 0001 jpo Number of Objects Actual 11 Number of Objects Reference 10 Actual Photo Reference Photo O Mixed Warning Limit 14 Click on the red dot with the highest2. Show Actual Photo C Show Ref Photo Load Photo Load Ref Photo Display Color Space Reset Image f Centre Nour Mode E High EA Low Select Colour Red ee es Green 0 45898 0 22588 Blue 0 17992 int Mode 0 1 Select Standard Colour By Mouse Pointer Expand Color Load Settings Save Settings 7 Click the Mask radio button to display the zoomed out part of the photo in black and white scale Photo Click Display Object button to open Object window Zoom In Select Photos Display Photo Actual Photo NC 0002 jpo Reference Photo Coordinates Display Objects x0 1476 xi 3428 Clear All vO 505 1 1807 Photo Size 1303 1954 Date O7 jul 2012 Time 10 44 09 Show Actual Photo Mask Show Ref Photo LoadPhoto Load Ref Photo Image gt olour Mode 0 45898 0 22588 Blue 0 17992 Int Mode 0 1 Close Select Standard Colour By Mouse Pointer Expand Color Save Settings Load Settings TiVi102 Nevus Analyzer 1 1 Sida 10 TiVi102 Nevus Analyzer 8 Click the Mixed radio button and then the Display Objects button to open the Objects window Objects Data Use remove sliders to remove too small and too large objects Filename NC 0002 jpg Actual Object Average Number Number 261 Area 77 52 Border 20 59 Colour 117 57 45 Diameter Diameter 4 93 Control Panel Display Remove Small
3. Data Filename NC 0002 jpg Actual Object Average Number 4 Number 9 Area 1839 Area 1492 66 Border 240 Border 255 38 Color 133 71 55 Colour 117 57 45 Diameter 48 Diameter 41 95 Control Panel Remove Small Objects Number of Objects 9 Remove Large Objects Size of Map 1303 x 1954 indicator Settings es Mode Colour 5 Small Size MediumSize Large Size RGB 133 69 60 7 2 i No Bins 10 D Short Distance Medium Distance Long Distance Histogram Type Area i Jbject Size 154 x 132 i Export Data 7 Set Object Size Show Histogram Display Map O E a 2 Scan Through Close TiVi102 Nevus Analyzer 1 1 Sida 13 TiVi102 Nevus Analyzer 13 Click the Scan Through button repeatedly to display the different objects and the associated parameters 14 Click the Export Data and select a name and folder to save the Excel file Open the Excel file to display the data File Name NC 0002 jp Red Green Blue 0 45898 0 225882 0 179922 Expand Mode Rem Smal Rem Large Coll Col2 0 1 Col Mode 501 5000 1476 3429 Number Avg Area Avg Borde Avg Colou Avg Diameter 9 1492 56 2533 38 253 38 41 95 Number Area Border 1 665 194 55 2 1057 267 90 3 2073 315 4 4 1839 240 1 3 2873 339 58 6 2413 285 7 1302 269 07 B 685 210 24 9 527 155 92 Diameter 29 09 36 68 51 37 48 38 60 48 55 42 40 71 29 53 25 9 15 This completes the GETTING STARTED section TiVi102 Nevus Analyzer 1 1
4. 1492 66 Border Border 255 38 Colour Colour 117 57 45 Diameter Diameter 41 95 Control Panel Remove Small Objects es Number of Objects 9 Remove Large Objects Size of Ma p 1303 x 1954 indicator Settings _ is 8 Modeco C Small Size Medium Size Large Size No Bins 10 Short Distance Medium Distance C Long Distance Jbject Size 154 x 132 Enumerate 1 Export Data 3 z Set Object Size Show Hmiogam poe Sed ees 2 Sean Tout Histogram Type Area v 11 Click the Enumerate button to display the object number next to the object TiVi102 Nevus Analyzer 1 1 Sida 12 TiVi102 Nevus Analyzer Objects Data Filename NC 0002 jpg Actual Object Average Number Number 9 Area 1492 66 Border 255 38 Colour 117 57 45 Diameter Diameter 41 95 Control Panel Remove Small Objects 2 LU Number of Objects 9 Remove Large Objects Size of Map 1303 x 1954 indicator Settings ae Mode Colour Small Size Medium Size Large Size No Bins 10 Short Distance Medium Distance Long Distance Histogram Type Area Z Sbiect Size 154 x 132 No Numbers 1 Export Data z Set Object Size Show Histogram Display Object EE 2 Scan Through Close 12 Click the Mixed radio button in the Display panel Then click the Scan Through button to display the different objects one by one The parameters for the object displayed are shown in the Actual Object panel
5. Photo Select Standard Colour SS Coordinates Expand Color a 0025 S x0 2452 x1 2004 Photo Panel 1 Photo text a text string that guides the user to the next step in the image processing process 2 Zoom In slider with edit box to zoom in on a specific part of the photo The section displayed is outlined in the Image Panel photo 3 Clicking in the photo placing the mouse pointer somwhere in the photo pressing the left louse button and moving the mouse with the button pressed causes the zoomed in region to move over the original photo Clicking on a spot inside the photo without moving the mouse generates a new photo with the colours representing the actual point displayed against a gray scale background photo The colour space the colours displayed is composed of colours around the colour of the point clicked on The size of this colour space is determined by the setting of the Expand Color slider 4 Photo size displays the size of the zoomed in photo TiVi102 Nevus Analyzer 1 1 Sida 23 TiVi102 Nevus Analyzer gt Date and Time displays the date and time of photo capturing Select Photos Panel 1 9 Load Photo button to load a new photo from file Load Ref Photo button to load a new reference photo from file Show Actual Photo rb button to display the actual photo Show Ref Photo rb button to display the reference photo Display Panel Pho
6. ratio exceeds the warning limit as set by the Warning slider Spots along the y axes spots existing only in the actual photo are indicated by yellow dots while spots along the x axis spots existing only in the reference photo are indicated by green dots The remaining spots are indicated by blue dots TiVi102 Nevus Analyzer 1 1 Sida 31 TiVi102 Nevus Analyzer 2 Any dot in the Diagram clicked on by the mouse pointer automatiaclly identified the corrsponding spot in the reference photo by circumventing it by a red square in the photo Photo Panel 1 Displays the photo mixed photo or the spots white on black background A red sqaure is automatically drawn around the spot corresponding to the dot clicked on by the mouse in the Diagram Display Panel 1 Displays filename of the actual and reference photo displayed as well as the number of objects in the corresponding photos 2 Photo radio button to display the full colour photos 3 Mixed radio button to display the spots of selected colour space colours against a gray scale version of the photo 4 Mask radio button to display the spots in the actual or reference photo in white colour against a black background 5 Actual photo to display the Actual Photo 6 Reference photo to display the Reference Photo 7 Export Data to export data to an Excel spread sheet 8 Refresh to remove the red square circumventiung the selected spot from the
7. x0 415 x1 3733 a ae a pts ers Reset TiVi Pre Processor Manual About Image Point and move mouse with the muose button pressed to move ROI Photo Size Intensity Mode 2213x3319 Date 20 nov 2012 Time 16 40 33 Photo Mask act 0002 jpg Reference Photo Select Standard Colour ref 0001 jpg Compare Images By Mouse Pointer z EEE m Coordinates Display Objects x0 415 x1 3733 a 5 The Mixed photo is now displayed TiVi102 Nevus Analyzer 1 1 Sida 16 TiVi102 Nevus Analyzer Manual About Use slider to zoom out Zoom In Select Photos Display L Photo Mixed Actual Photo act 0002 jpc Reference Photo ref 0001 jpg Coordinates Display Objects _ x0 415 x1 3733 Clear All Si TiVi Pre Processor Manual About Click Display Object button to open Object window Zoom In Date Time 16 40 33 20 Select Photos Display Photo Mixed Mask Actual Photo act 0002 jpg Reference Photo ref 0001 jpg Coordinates xO 415 x1 3733 vO 277 vij 2459 Load Ref Photo Display Color Space Photo Size 2213x3319 Date 20 nov 2012 Time 16 40 33 Show Actual Photo Show Ref Photo Load Photo Reset Photo Size 2213x3319 20 nov 2012 Show Actual Photo Show Ref Photo Load Photo Load Ref Photo Display Color Space Reset Image intensity Mode S
8. Actual Area value in the Diagram The corresponding spot is now identified in the photo by circumscribing it with a red rectangle JZ Actual Area 500 1000 Reference Area Display Filename Actual act 0002 jpa Filename Reference ref 0001jpo Number of Objects Actual 19 Number of Objects Reference 14 Actual Photo Reference Photo O Mixed Warning Limit TiVi102 Nevus Analyzer 1 1 Sida 21 TiVi102 Nevus Analyzer 15 Check the Mask radio button to display the corresponding black and white photo By Piot 102 e xa Diagram Photo Mixed Mask Actual Photo Reference Photo Warning Limit 2 Export Data Refresh Close 16 Check the Refresh button to hide the red rectangle circumscribing the actual spot Check the Actual Photo radio button and then the Reference Photo radio button to verify that the actual spot is indeed larger in the Actual photo than in the Reference photo 17 Click the Export Data button to export the results to an Excel file Open the Excel file to display the data set 18 This completes the COMPARISON OF NAEVI MAPS section TiVi102 Nevus Analyzer 1 1 Sida 22 TiVi102 Nevus Analyzer 5 DETAILED DESCRIPTION The TiVi102 Nevus Analyzer main window TiVi Pre Processor Manual About Image Point in photo to select colour of interest Intensity Mode Zoom In Date 20 nov 2012 Time 16 40 41 act 0002 jpq Reference
9. Objects 7 eae Photo es ee Remove Large Objects size of Map 1303 x 1954 indicator Settings nf 00 a Small Size Medium Size Large Size No Bins 10 Short Distance Medium Distance Long Distance Histogram Type Area m Show Histogram Display Object 9 This sub photo includes 261 objects To eliminate the smallest objects move the Remove Small slider to its rightmost position The smallest objects are now deleted and only 9 objects remain in the zoomed in window The average area border colour and diameter of these 9 objects are displayed in the Average panel TiVi102 Nevus Analyzer 1 1 Sida 11 TiVi102 Nevus Analyzer Objects Click the Scan Through button to scan through the objects Data Filename NC 0002 jpg Actual Object Number Area 1492 66 Colour 117 57 45 Control Panel Remove Small Objects i e of Objects 9 Remove Large Objects Size of Map 1303 x 1954 Indicator Settings EE es 8800 Mode Colour Small Size Medium Size Large Size No Bins 10 Short Distance Medium Distance Long Distance Histogram Type Area X Object Size 154 x 132 Enumerate 1 Export Data j Set Object Size Show Histogram Display Object 2 Scan Through Close a 10 Click the Mixed radio button to display the selected nevus lesion objects against a gray scale coloured skin background Data Actual Object Average Number Number 9 Area
10. Sida 14 TiVi102 Nevus Analyzer 4 COMPARISON OF NAEVI MAPS In the following example it is explained how the areas of different naevi in two different photos can be compared and how an enlarging spot can be automatically identified 1 Open the Nevus Analyzer toolbox from the Toolbox pull down menu in the TiVi700 Analyzer window 2 Click the Load Photo button navigate to the 71Vil02demonstration toolbox and double click on the Act O001 photo TiVi Pre Processor Manual About Image Point and move mouse with the muose button pressed to move ROI Photo Size Intensity Mode Zoom In 2213x3319 pa 20 Select Photos Select Colour Red Display ee FS Show Actual Photo Photo Mixed Green ae TE ee Show Ref Photo Actual Photo Reference Photo Select Standard Colour Load Ref Photo Compare Images By Mouse Pointer Coordinates z Expand Color Display Objects Display Color Space EA R G x0 415 x1 3733 om maa se 3 Click the Load Ref Photo and double click the Ref O00 photo TiVi102 Nevus Analyzer 1 1 Sida 15 TiVi102 Nevus Analyzer TiVi Pre Processor Manual About Image Point and move mouse with the muose button pressed to move ROI Photo Size Intensity Mode 2213x3319 Date 20 nov 2012 Time 16 40 33 Photo Mask act 0002 jpg Reference Photo ref 0001 jpg Compare Images By Mouse Pointer Coordinates Display Objects Display Color Space Ea
11. TiVi Pre Processor Manual About Glosli Bridge Photo Point in photo to select colour of interest Zoomin Objects Click the Photo Mixed or Mask radio_button to display different views Select Photos Display Photo O Maxed Actual Photo NC 0002 jpg Reference Photo Control Panel Remove Smal Objects a ee Remove Large Objects s000 Smal Size Medum Size Large Size No Bins 10 Short Distance Medum Distance Long Distance Area X Nevus Analyzer TiVi102 User Manual User Manual 1 1 Version 1 1 December 2012 PIONEERS IN TISSUE VIABILITY IMAGING TiVi102 Nevus Analyzer Dear Valued Customer Welcome to the WheelsBridge TiVil02 Nevus Analyzer toolbox intended for automatic analysis of naevi moles and skin spots of different colours The TiVil02 Nevus Analyzer was designed for observer independent analysis of skin spots in association with evaluation of skin care products and for medical research applications The WheelsBridge TiVi 102 Nevus Analyzer utilizes a highly sensitive digital camera equipped with polarization filters making it possible to suppress surface reflections from the skin The versatile system software based on the MATLAB high performance language for technical computing allows for rapid and easy capturing and analysis of images Among the many useful features of the TiVi 102 Nevus Analyzer software the following are of particular interest e Automatic captur
12. elect Colour Red Green Blue Select Standard Colour By Mouse Pointer Expand Color Load Settings Save Settings Image Intensity Mode Select Standard Colour iene oi ero By Mouse Pointer v Expand Color 0 33882 0 14196 0 064 _Col Mode 0 05 ie 0 33882 0 14196 0 064 Col Mode 0 05 Save Settings Load Settings cose 7 Drag the Expand Color slider somewhat to the right to expand the colour space and include more spots TiVi102 Nevus Analyzer 1 1 Sida 17 TiVi102 Nevus Analyzer TiVi Pre Processor Manual About CU denle rite Photo Click Display Object button to open Object window Zoom In Photo Size 2213x3319 Date 20 nov 2012 Time 16 40 33 0 Mixed Mask Actual Photo act 0002 jpo Reference Photo ref 0001 jpa Display Objects Clear All TiVi Pre Processor Manual About OC dene ridge Photo Click Display Object button to open Object window Zoom In Date Time 16 40 41 20 Select Photos Mask Photo Mixed Actual Photo act 0002 jpg Reference Photo ref 0001 jpg Display Objects Clear All 9 Select Synch Actual to Ref in the Select Standard Colour pull down menu Show Actual Photo Show Ref Photo Load Photo Load Ref Photo Display Color Space Reset Photo Size 2213x3319 20 nov 2012 Show Actual Photo Sh
13. en limit of the Colour Space 5 Blue Low Limit displays the low blue limit of the Colour Space 6 Blue High Limit displays the high blue limit of the Colour Space Select Colour Space Panel 1 ROI rb button displays the results in the RGB Colour Space 2 HSV rb button displays the results in the HSV Colour Space 3 Close button closes the Colour Space window 4 Diagram rotation to rotate the diagram by pointing on it with the mouse pointer and pressing the left mouse button while moving the mouse TiVi102 Nevus Analyzer 1 1 Sida 26 TiVi102 Nevus Analyzer The Object window Control Panel Remove Small Objects Remove Large Objects _ Ss 5000 No Bins 10 Histogram Type Area Show Histogram Display Object Object Panel 1 Number of Objects 109 Size of Map 980 x 1470 Mode Colour Data Filename NC 0002 jpg Actual Object Number Border Diameter Display Photo Indicator Settings Small Size Short Distance Enumerate Set Object Size nt 2 Border 22 03 Colour 118 58 41 Diameter 5 17 Mask Medium Size Large Size Medium Distance Long Distance 1 Export Data Scan Through Close Photo text a text string that guides the user to the next step in the image processing process Photo displays the zoomed in photo imported from the TiVi 02 Nevus Analyzer ma
14. es and colour in experimental and research applications It is not yet approved for the diagnosis and treatment of disease TiVi102 Nevus Analyzer 1 1 Sida 3 TiVi102 Nevus Analyzer 2 OPERATING PRINCIPLE The basic operating principle of the TiViJ02 Nevus Analyzer is probably best explained by a flow chart Fig 1 After having captured a high resolution photo typically 18 Mpixels of the central part of the skin of the back this photo is uploaded to the 7iVi 02 Nevus Analyzer Upload the photo Zoom in ona Nevus Click to set colour space Display objects within Eliminate too small and selected colour space too large objects Export data to Excel Inspect the objects one by one Fig 1 Basic operating principle Flow Chart 1 Upload the photo to the 77Vil02 Nevus Analyzer 2 Zoom in and move the zoomed in window over the photo until a representative nevus becomes visible 3 Click on the nevus in the photo to display its colours against gray scale background the colour space around the centre colour can be selected by the user Alternatively the intensity of the nevus can be used for colour space discrimination 4 Zoom out until the target size of the sub photo is attained All nevus lesions within the selected colour space become visible TiVi102 Nevus Analyzer 1 1 Sida 4 TiVi102 Nevus Analyzer 5 The individual nevus lesions are converted to individual objects Their location can be d
15. iVi102 Nevus Analyzer 5 Click on the nevus lesion in the zoomed in photo without moving the mouse The selected nevus lesion will now be displayed against the surrounding skin displayed in gray colour scale TiVi Pre Processor Manual About Image 3 Photo Size a Use slider to zoom out 435 652 Colour Mode Zoom In Date 07 jul 2012 Time 10 44 09 Show Actual Photo Show Ref Photo Actual Photo J Blue NC 0002p3 EO O ee AE Reference Photo Select Standard Colour Load Ref Photo By Mouse Pointer Int Mode 2 Coordinates Expand Color Display Objects Display Color Space i a x0 1526 xi 2177 7 a 6 Move the Zoom In slider downwards to zoom out the photo to a size suitable for further analysis The zoomed out window can be moved over the original photo by placing the mouse pointer on the photo pressing the left mouse button and dragging the mouse pointer to a new position The site of the zoomed out window is outlined in the original photo displayed in the Image panel TiVi102 Nevus Analyzer 1 1 Sida 9 Ani TiVi Pre Processor Manual About inl Ciridige Photo Point in photo to select colour of interest Zoom In Select Photos Display Photo Mixed Actual Photo NC 0002 jpo Reference Photo Coordinates Display Objects x0 1476 xi 3429 Clear All vO 505 y1 1807 TiVi102 Nevus Analyzer Photo Size 1303 1954 Date O7 jul 2012 Time 10 44 09
16. in window Panel File Name displays the filename Actual Object Panel displays number area border colour and diameter of the object nevus lesion selected Average Panel displays number of nevus lesions and average area border colour and diameter of the nevus lesions in the zoomed in photo TiVi102 Nevus Analyzer 1 1 Sida 27 TiVi102 Nevus Analyzer Control Panel 1 Remove Small Object slider amp edit box removes small objects from the zoomed in photo 2 Remove Large Object slider amp edit box removes large objects from the zoomed in photo 3 No Bin edit box to set the number of bins in the histogram 4 Histogram Type pull down menu to select the type of histogram to be displayed area border or diameter 5 Show Histogram button toggles between Show histogram Show Image to display histogram or image 6 Display Object button toggles between Display Object Display Map to display individual objects single nevus lesions or image map 7 Number of Objects text displays the number of objects in the zoomed in photo 8 Size of Map text size of map diplayed 9 Mode text indicates mode of operation Intensity Mode or Colour Mode 10 Display Panel Photo Mixed amp Mask displays the zoomed in photo as pure colour photo coloured nevus lesions against gray background skin or black and white object mask 11 Indicator Settings Panel to se
17. indow Reference Photo Click on the Reference Spot red square in the Actual Photo Actual Photo Panel 1 Displays File Name and Number of Objects in Actual Photo Reference Photo Panel 1 Displays File Name and Number of Objects in Reference Photo Controls Panel 1 Remove Small Objects slider to remove small objects from the photos 2 Remove Small Objects edit to remove small objects from the photos 3 Enumerate to display number of the objects in the reference photo 4 Show Plot to open the Plot 02 window 5 Close to close the Compare 102 window TiVi102 Nevus Analyzer 1 1 Sida 30 TiVi102 Nevus Analyzer Display Panel 1 Photo radio button to display the full colour photos 2 Mixed radio button to display the spots in colour space colours superimposed on the full photo displayed in gray scale colour 3 Mask radio button to display the spots in white colour on black background The Plot 102 window 1000 f Actual Area 1000 Reference Area Display Filename Actual act 0002 jpg Filename Reference ref 0001 jpg Number of Objects Actual 11 Number of Objects Reference 10 Actual Photo Reference Photo Diagram Panel 1 Displays areas of spots in the actual photo versus the corresponding areas of the spots in the reference photo Actual photo spot sizes are displayed as red dots if the corresponding actual spot reference spot areas
18. ing of photos e Automatic tracking of skin objects by colour or intensity discrimination e Removal of large and small objects from the nevus lesions map e Individual display of objects nevus lesions by a scanning through procedure e Individual determination of object area border colour and diameter e Comparison of two naevi maps lesion by lesion e Small objects removal from plot possible e Automatic identification of spots with growing areas e All data can be exported to ASCII format spread sheets We are convinced that the TiVil02 Nevus Analyzer will be a productive tool in the assessment and follow up of human skin treatment with skin care products and in medical research Thank you for choosing the WheelsBridge TiVil02 nevus Analyzer WheelsBridge AB TiVi102 Nevus Analyzer 1 1 Sida 1 TiVi102 Nevus Analyzer Information in this document is subject to change without notice and does not represent a commitment on the part of WheelsBridge AB No part of this manual may be reproduced or transmitted in any form or by any means electronically or mechanically including photocopying and recording for any purpose without the written permission of WheelsBridge AB Any use of application of WheelsBridge products must be performed by properly trained and qualified personnel WheelsBridge AB takes no responsibility for action taken on the basis of information derived from the use of the product described in this manual or fr
19. isplayed as a black and white map 6 Too small and too large objects can be eliminated the user sets the size elimination threshold 7 The remaining individual objects nevus lesions can be displayed one by one Their area border colour and diameter are calculated and displayed 8 All calculated data can be exported to an Excel spreadsheet 3 PHOTO CAPTURING When capturing photos for the 7iVi 02 Nevus Analyzer use the highest camera resolution and place the camera about m away from the object This will give a field of view of about 430 mm x 290 mm and a resolution better than 0 1 mm per pixel Set the filters to cross polarized mode Set the AutoFocus switch to AF and the Stabilizer to ON Use the zoom in feature to attain a field of view that captures a photo of the central part of the back Fig 2 in order to avoid shadows from the periphery and to get the highest resolution allowing also small skin objects to be included and analyzed Fig 2 Place the camera one meter away from the object and use the zoom in feature to attain a field of view that includes the central part of the skin of the back Open the TiVi70 Camera window and set the Size Reduction to Minor under the Size Reduction pull down menu the Select Photo Size to Large Fine and the No of Photos to 1 in accordance with Fig 3 TiVi102 Nevus Analyzer 1 1 Sida 5 TiVi102 Nevus Analyzer Size Reduction Cameras Supported Registe
20. ntre point are set to 0 25 0 15 0 1 and the Expand Color slider value to 0 1 Synchronize the Colors Space of the photo in focus is synchronized made equal to that of with the hidden photo After having clicked on a nevus to define a colour space two more items are added to the pull down menu if both the actual and the reference photo are uploaded Synch Act to Ref synchronizes the colour space of the actual photo to that of the reference photo while Synch Ref to Act synchronizes the colour space of the reference photo to that of the actual photo After synchronizing the colour spaces of the two photos the Compare Images button is enabled 6 Compare Images button to open the Compare 102 window 7 Int Mode button this toggle button sets the system to operate in Colour Mode or Intensity Mode 8 Load Settings loads saved parameter settings from file 9 Save Settings saves parameters to file 10 Close closes the 7iVil02 Nevus Analyzer Toolbox TiVi102 Nevus Analyzer 1 1 Sida 25 TiVi102 Nevus Analyzer The Colour Space window Limits RedLowLim 93 RedUpLim 144 GreenLowLim 33 GreenUpLim 84 BlueLowLim 16 BlueUpLim 67 Limits Panel 1 Red Low Limit displays the low red limit of the Colour Space 2 Red High Limit displays the high red limit of the Colour Space 3 Green Low Limit displays the low green limit of the Colour Space 4 Green High Limit displays the high gre
21. olours in the mask 2 Centre edit box displays the centre colour of the Colour Space 3 High edit box displays the brightest colour included in the Colour Space TiVi102 Nevus Analyzer 1 1 Sida 24 TiVi102 Nevus Analyzer 4 Low edit box displays the darkest colour included in the Colour Space 5 Size displays the size of the photo in pixels Select Colour Panel 1 Red slider amp edit box sets the red centre colour automatically updated when a pixel is pointed on in the photo in the Photo Panel 2 Green slider amp edit box sets the green centre colour automatically updated when a pixel is pointed on in the photo in the Photo Panel 3 Blue slider amp edit box sets the blue centre colour automatically updated when a pixel is pointed on in the photo in the Photo Panel 4 Expand Colour slider amp edit box sets the extension of the Colour Space around the centre colour Colour Mode or intensity threshold level above the centre intensity Intensity Mode 5 Select standard Colour pull down menu sets predetermined centre colours and width of Colour Space and updates the sliders and edit boxes accordingly By Mouse Pointer the Color Space is set by pointing at a point in the photo and clicking the left mouse button Light Nevus The RBG values of the centre point are set to 0 5 0 3 0 2 and the Expand Color slider value to 0 1 Dark Nevus The RBG values of the ce
22. om consequential damages in connection with furnishing performance or use of this manual Licensee s limited rights are governed by the license agreement between WheelsBridge AB and MathWorks Licensee may not modify or remove any license agreement file MarthWorks or third party that is included with the MCR Libraries MCR Library License Licensee of this Application accepts the terms of the MCR Library License WheelsBridge is a registered trade mark TiVi102 Nevus Analyzer 1 1 Sida 2 TiVi102 Nevus Analyzer 1 INTRODUCTION Nevus moles birthmarks brown spots is the medical term for well defined and benign lesions of the skin Skin cancer especially malignant melanoma however may arise from pre existing nevus lesions It is therefore of interest to closely follow the development of nevus spots with respect to changes in colour area border and diameter over time and pay special attention to protecting sensitive skin from UV radiation and other skin damaging factors The TiVil02 Nevus Analyzer makes it possible to automatically track important nevus parameters such as area border colour and diameter and quantify how these parameters vary over time and over the skin surface It is further possible to compare the change of individual naevi areas in two different photos and automatically detect spots with enlarged areas The intended use of the 7iVil02 Nevus Analyzer is to analyse skin spots of different shap
23. ow Ref Photo Load Photo Load Ref Photo Display Color Space Reset ima ge intensity Mode Select Colour Red _ hE eee Green Blue Select Standard Colour Centre High Low 0 33882 0 14196 0 064 Col Mode By Mouse Pointer Y Expand Color 0 097656 Save Settings Load Settings Image intensity Mode Select Colour Red EEEE Eas Green Blue Select Standard Colour Centre a High E Low By Mouse Pointer Y Col Mode Expand Color Save Settings Load Settings TiVi102 Nevus Analyzer 1 1 Sida 18 TiVi102 Nevus Analyzer TiVi Pre Processor Manual About Hanti Brnie Photo Image Click Display Object button to open Object window Photo Size Intensity Mode Zoom In 2213x3319 Date 20 nov 2012 Time 16 40 41 Select Photos Select Colour Red Dispis EE e ee A ai Show Actual Photo Mixed Mask Green ssa aka a 141E Actual Photo i Blue mainis Load Photo a 0 064 Reference Photo Select Standard Colour ref 0001 jpg Load Ref Photo Compare Images Synch Actualto Col Mode f Coordinates Expand Color Display Objects _ Display Color Space es 80975 xO 415 x1 3733 Clear All TES ache Reset 10 Click the Compare Images button Actual Photo me _
24. photo 9 Close to close the Plot 102 window TiVi102 Nevus Analyzer 1 1 Sida 32
25. r Language Manuals About Demo Assistant Registration Size Reduction Minor Photo Large Fine g Pause 1 No of Photos 5 Delay sec Please switch off ambient light and use blue or green colour background Controls Fig 3 Setting Camera parameters in the TiVi70 Camera window Power the Illuminator and switch off the ambient light in the room Capture a photo and store it in the selected folder under the selected name in the computer 3 GETTING STARTED The basic features of the 7iVi 02 Nevus Analyzer are probably best explained by way of an example In the following example it is assumed that the photo nevus O001 jpg has been captured by a Canon EOSS50D 650D TiVi camera system and stored in the 77Vi 02 demonstration folder This photo displays the central part of a back with a number of nevus lesions of different sizes and colours 1 Open the Nevus Analyzer toolbox from the Toolbox pull down menu in the 77Vi700 Analyzer window TiVi102 Nevus Analyzer 1 1 Sida 6 TiVi102 Nevus Analyzer TiVi Pre Processor Manual About Image Photo Size Point in photo to select colour of interest Colour Mode Zoom In Select Photos Select Colour Displa Red a E EEE vay Show Actual Photo i Photo Mixed reen Show Ref Photo cen Actual Photo NC 0002 jpg Blue Reference Photo Select Standard Colour Load Ref Photo By Mouse Pointer aE x we Coordinates F 7 A Expand Color Display Objec
26. t the size of numbers and their distance to the objects in the black and white image 12 Enumerate button toggles between Enumerate No Numbers to display or hide object numbers in the black and white image 13 Export Data button to export data to Excel file 14 Set Object Size slider and edit box to set the size of the individual object photo With the slider set to zero the boundaries of the largest object fills the entire photo 15 Scan Through button and edit box scans through and displays the individual objects while updating the Actual Object panel parameters accordingly 16 Close button to close the Object window TiVi102 Nevus Analyzer 1 1 Sida 28 TiVi102 Nevus Analyzer Objects Data Click the Photo Mixed or Mask radio_button to display different views Filename NC 0002 jpg Actual Object Number S Area 4703 Area 1317 83 Border 440 Color 126 68 50 Colour 118 58 41 Diameter 36 2 Control Panel Remove Small Objects Number of Objects 6 Remove Large Objects Size of Map 980 x 1470 Indicator Settings os 5000 oie Colour Small Size Medium Size Large Size No Bins 10 Short Distance Medium Distance Long Distance Histogram Type Area X z F Set Object Size Per ee Stee Sepa zany Mee i Object window with a single object nevus lesion displayed TiVi102 Nevus Analyzer 1 1 Sida 29 TiVi102 Nevus Analyzer The Compare 102 w
27. to Mixed amp Mask check the Photo radio button to display the entire photo in colour Check the Mixed radio button to display the coloured nevus lesions against gray scale background skin Check the Mask radio button to display the photos as black and white images Actual Photo edit box displays the name of the actual photo Reference Photo edit box displays the name of the reference photo Display Objects button opens the Object window and transfers image information to this window Clear All button deletes photos and resets the system to start mode 10 Display Colour Space button opens the Colour Space window 11 Reset button resets the settings but keeps the photos uploaded and displayed 12 Coordinates Panel displays the coordinates of the zoomed in photo Image Panel 1 Image text displays the selected mode Coulour Mode indicates that the Colour Space is selected with the centre colour widened by the settings of the Expand Colour slider In this mode a dark nevus lesion can contain a core area outside the selected Colour Space Intensity Mode default indicates that the Intensity is selected with the centre intensity increased by the setting of the Expand Color slider In this mode all pixels of an intensity lower than the centre intensity increased by the Expand Color slider setting are included in the nevus lesions identified i e a dark nevus lesion will include its centre darker c
28. ts Display Color Space x0 843 x1 2243 Clear All I ae Reset Load Settings Save Settings 2 Click the Load Photo button and navigate to the 71Vi 02 demonstration folder and select the nevus O001 jpg TiVi Pre Processor Manual About Image Colour Mode Date 07 jul 2012 NC 0002 jpq Reference Photo Select Standard Colour By Mouse Pointer 3 Move the Zoom In slider upwards to about 90 of its maximum value The part of the photo displayed in the Photo panel is outlined in the Image panel photo TiVi102 Nevus Analyzer 1 1 Sida 7 TiVi102 Nevus Analyzer x TiVi Pre Processor Manual About Image Photo Size Point and move mouse with the muose button pressed to move ROI 435 652 Colour Mode Actual Photo NC 0002 jpg Reference Photo Select Standard Colour By Mouse Pointer Coordinates Expand Color O O x0 1745 x1 2399 anaa i Save Settings 4 Place the mouse pointer on the photo displayed in the Photo panel Press the left mouse button and drag the mouse over the photo Release the mouse button Repeat the procedure until a representative nevus lesion appears in the zoomed in photo TiVi Pre Processor Manual About Image Colour Mode Date 07 jul 2012 NC 0002 jpg Reference Photo Coordinates x0 1526 x1 2177 vO 2004 vi 2438 TiVi102 Nevus Analyzer 1 1 Sida 8 T
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