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1. How do you add reference beats Displaythe beat of interestin the 2D Editor view Right click on the chart and select Set as reference beat What is the consequence on reference beat numbering Reference beats identification numbers are updated according to the chronological order of their occurrence See Figure 31 Addition of a reference beat Removal of a reference beat 12 31 4 i 31 gt 7 ay 5 3 Lu Remove a reference beat When do you need to remove a reference beat This option may be useful when areference beat is identified on a beat where manual positioning of fiducial points is difficult or not possible several reference beats are detected in a noisy zone that is not really of interest to you How do you remove a reference beat In the 2D Editor view display the reference beat you want to remove Right click on the chart and select Remove reference beat What is the consequence on reference beat numbering Reference beats identification numbers are updated according to the chronological order of their occurrence See Figure 31 Find the origin of an interval instability The non synchronized continuous display shows calculated data such as interval durations It is useful to observe potential drug effects and monitor data quality Instability on QRS duration data is circled on Figure 32 Advanced Tutorials Calibration Published on October 27 2011 45 60 My NOTOCORD User Ma
2. Ctrl S Activates Scrolling function Ctrl F on graph Displays the selected graph on full screen Tiles graphs in the selected display Ctrl drag amp drop on graph Horizontal zoom in Shift drag amp drop on graph Vertical zoom in Ctrl Shift drag amp drop on graph Zoom in on a selected signal region Ctrl drag amp drop on X axis Expands Compress axis Ctrl Right arrow Expands X axis Ctrl Left arrow Compresses X axis Ctrl Up arrow Expands Y axis Ctrl Down arrow Ctrl Xon graph Ctrl Xon graph Compresses Y axis Changes X axis scale to show whole signal Changes Y axis scale to show whole signal Right arrow Navigates forward on X axis Left arrow Navigates backwards on X axis Up arrow on graph Y axis Navigates upward on Y axis Down arrow on graph Y axis Navigates downward on Y axis Shift Right arrow or Left arrow Navigates on X axis by as much as the scale range defined in the Graph properties window Shift Up arrow or Down arrow on graph Y Nadgates on Y axis by as much as the scale range defined in the Graph axs Shift F3 Shift F4 Shift F5 ECG51a properties window Adjusts graphs to window display size Tiles displays horizontally Tiles displays vertically Appendix gt Shortcuts in NOTOCORD hem Published on October 27 2011 56 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Shortcut Ctrl click on beat Ctrl double click on
3. Deep LEMOA RAT LICEHSE FOA NOTOCORCHAEH Ev LUTIDN TEST Oros nic PRODIT Ug al dg K FH Za METODO pan E pkuhn bor Boquieition necosdeg Bind ansiece of sigeakisedeo dara El Ml Deed Woms Life hel equation up In 4 decer Ej vHATDa Legs ikee A Anales E SAL Dohas sampling fe ASPs Aecinarnd ermal erpa abon ardeat E 075502 DiakaT ral cad Ean chanel acquisition sere E Etip Darsma preas slack oo um arabe install cenam bon fin 3 dnce adl cr om kom inpr rie 5 Lira adl koe Select the license to be uninstalled Click on Uninstall license Now these modules appear in the upper grid of Token Manager Case n 3 License Transfer When should you transfer your license e Installation of the license on another computer Changing computer Transfer procedure Uninstall your license following the chapter Case n 2 License Uninstallation instructions Reinstall your license following the chapter Case n 1 License Installation instructions Case n 4 License Modification When should you modify your license Purchase of a new module e Purchase of a new functionality Move to GLP Setup gt License Installation Published on October 27 2011 20 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Procedure Insert the floppy disk with your new module into the floppy drive Launch TokenManager program Click on Refresh 39 HOTOCORD akenldanager D natal licer dera Bie 90 rcr adi ic
4. Enter a Label to identify the event marker Select the event marker Type 0 to 99 the default type is 0 Click OK Urmovesbla Type Position sec 1 02 Injection A The event markers label and its order number with respect to the type and channel will now be displayed above the corresponding line in the example shown the event marker is of type 2 and F1 corresponds to channel 1 The other event markers for this channel are renumbered accordingly Switching from one event marker to another You can navigate directly from one event marker to another of the same channel There are three ways to do this Right click an event marker and choose the destination Double click an event marker select the target marker number and click Go to e Select an event marker and use one of the following keyboard shortcuts Ctrl M next marker of the same channel Shift Ctrl M previous marker of the same channel Moving an event marker The default settings do not allow you to move event markers once they have been positioned If necessary you can reposition a marker by unchecking the Unmovable boxin its Marker properties window Get Started Using event markers Published on October 27 2011 31 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Managing files Table of Contents 1 Saving the current configuration 2 Saving the data file under another name 3 Loading a configuration othe
5. To delete a module click it and press the Delete key Important You cannot set up a module during acquisition except for display modules which can be set up any time Linking two modules Set up a second module CTD60a module in this example to the right of the first module Click the sign on the display module once to obtain two display graphs each successive click adds a graph Note As soon as the display module is set up the corresponding display window shows up in the Main window Depending on the number of graphs selected the display window will be divided into an equivalent number of sections Click and drag the output of the NSR10a module towards the corresponding input of the CTD60a module When you see that the target input is covered by a yellow grid you can release the me gt mouse Module name modification Amodule s default name consists of its function followed by an order number CYC10a1 m pT CTD60a2 m Proper Get Started Configuring acquisition Published on October 27 2011 23 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Displaying signals Table of Contents 1 Starting the acquisition process 2 Zoomand scaling options 3 Additional display options Once you have configured your test you can display the acquired signals as well as the results of the various processing tasks applied to them Note The following example corresponds to the con
6. You can add your own marks with the associated keyboard shortcuts by clicking on the button at the bottom of the screen Calculated data tab Adefault listed is available gt You can add your own calculated data by clicking on the button at the bottom of the screen and by indicating the calculating formula Time1 corresponds to Mark1 and Time2 to Mark2 When you are finished with setting your configuration Click on OK to validate Right click on ECG51a Select Show to switch to the display screen Figure 7 Show Condensed Analyze signal Edit Properties ECG51a analysis The analysis is performed in 3 steps 1 Reference beats identification 2 Reference beats marking 3 Signal analysis Reference beats identification In the ECG51a display window click on Identify reference beats Figure 8 The number of reference beats appears in the horizontal bar above the 2D 3D chart menu In Figure 9 18 reference beats are identified by ECG51a with 41 being displayed Advanced Tutorials gt Calibration Published on October 27 2011 40 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems eco OA Reference beats marking The first reference beat is displayed in the 2D 3D chart Figure 10 Click on the chart to activate it e Use either keyboard shortcuts to mark the reference beat P Q R S T or right click on the chart to open the pop up menu and
7. 1 Baan J Van der Velde ET de Bruin HG Smeenk GJ Koops J van Dijk AD Temmerman D Senden J and Buis B Continuous measurement of left ventricular volume in animals and humans by conductance catheter Circulation 1984 70 812 823 2 Feldman MD Erikson JM Mao YI Korcarz CE Lang RM and Freeman GL Validation of a mouse conductance system to determine LV volume comparison to echocardiography and crystals American Journal of Physiology amp Heart Circulation Physiology 2000 279 H1698 H1707 Advanced Tutorials PV Loop Published on October 27 2011 51 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Appendix Error index Error messages encountered when using our modules and applications and related causes Table of Contents BUX10a EOG31p ECG51a EEG10a License Management MA10a PVL10I PV L10s QRS10a 10 TVS31a 11 VN10a 12 VVE10v 13 VSH10a b 14 XY D80a OMPNAARWBN gt Please find below error messages displayed when using NOTOCORD hem and modules message cause table This list is not exhaustive and wil be updated as new error messages or outputs are listed BUX10a Message No Buxo device detected Please check your Absence of any Buxco device or of an hardware setup and your license appropriate license The Buxco device is already in acquisition with different sampling frequencies Click here to apply the same sampling frequencies to this configuration This configurati
8. identify z CER Mon synchronized Reference beats lt ud continuous display chart Hide Show top ar right panels Purple arrow showing the active beat 2D 3D display chart Statistics table Modules configuration in NOTOCORD hem The ECG51a module has 3 inputs ECG red QRS green and Markers pink and 10 outputs as standard Figure 4 This number may vary as more outputs can be added The QRS trigger can be provided by any module able to detect a cycle or an R wave Use of the QRS output of the QRS10a module delivered with ECG51a is recommended since QRS10a has been specifically developed for this application Connect the ECG signal on the red input of both QRS10a and ECG51a modules Connectthe QRS output to the green ECG51a input QRS trigger generation with QRS10a module ECG51a analysis is triggered by QRS detections which can be generated by QRS10a There are 2 tabs in the QRS10a properties window Figure 5 ORS10a1 properties Age Dima gt Minimal RAR duration ms Maximal RA duration ms E000 E A wave duration mel 10 120 bd Apply a preset gt gt Conscious dag Anesthetized dog Choose a preset in the lis Non human primate values Pig Minipig Guinea pig Rabbit Rat Mouse The firsttab Algorithm allows selection of a preset for species and experimental setup e Setthe algorithm parameters or select a preset e Validate it by clicking on OK Recalculate the
9. Channel 2 is assigned to the ABP signal Switch to the Main window Start the acquisition and then press the F1 and F2 keys several times in any order Stop the acquisition Event markers are represented by long vertical lines of various colors each event marker has its own color Above each event marker line there is an order number a dot and a box containing the function key associated with the corresponding marker For example the number 3 above the F2 boxstands for the third event marker of channel 2 Get Started Using event markers Published on October 27 2011 30 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems FA F1 FA FA F1 F2 F2 F2 r2 Note You can have two identical numbers one after the other when they correspond to different event marker channels Ein scam F Click on the signal with the right side mouse button m In the context sentive menu choose nsert marker and select one of the two channels with the erii left side mouse button Send to dipboard Ade OR E 3 Amarker is inserted and is displayed on the graph l z ra z DEER pipas Specifying event marker labels and types Double click an event marker you can double click the corresponding line dot or box to display Pasua the Marker properties window for this marker The Number field indicates the order number for the marker you selected for example 2nd event marker of event marker channel 1
10. Data sub directory of Program Files simple users are limited to read only access as itis the default Windows configuration for this directory The installation process is longer when the workfile directory already contains many files The process is extended by the time needed to assign specific NTFS rights to these files f you select another directory you should then apply NTFS access restrictions i e set read only mode for simple users If you select custom directory for each user the installation program will not be able to automatically set the specific NTFS rights Once the workfile directory has been selected click on Next i NOTOCORD hem Evolution 4 2 0 2372 Setup Data Manager Account Select data manager account Select the Windows account that yal have access bo the workhle direcion Windows Account ame Based Confirmation Saar In parallel an NTFS secunty strategy has bo be applied to the workhile directory to control access from other accounts If no account e entered access lo the worklile directory vill be allowed lo al accounts Select User Select this object type User From this location Entire Directory Enter the object name to select examples Select just one account in the standard Windows dialogue boxto select the user Once selected this account appears in grey in the Account field Type the password corresponding to this account in the Passwo
11. IM el at e D UII 24 ZOOM and Scallng OPHOAS art ds TIT 24 Additionalkdisplay OPONE eee 26 Bine MIT iT TT TTD LT DTE PPP 30 ers hoy heal 9a 6 0 c TTE D DT UO Oc 30 CONMOUFAU op Rc etd HET AA ia 30 DNS NAY mw Tr E M e 30 Managing ESTNE TETTE T TETTE TET TT Tee 32 Saving the c rrenticonttaldlleblOT s a c edu Eod 30 Fe oa Fed cct ee docs ei Save soa eds e E Pi dsc 32 Saving the data file Under another namne sas ase a adnata Val nee aE Gua aor que a dcc ascende ed Init ductu d aou acqua D eosdem ei rA uas On aiat 32 Eoading a contguratuorr other than the current One iii A ret Vel cu Qa pd Re cU een aac rS VS ME ERE vane 32 opening d deke 168 ooi touc sva A ME uides ut A A rope vU ERA E A LA robs V ead NE du e a tute e duse AU 32 Creatitittiewdeta MIE oen ceosict tare A a D co dee Scu LI ps OS ed 32 Saving the cuLrent Connguration as a Memo casco Suede dad du et vet oe A dco n CO beu c e d eu ro de dea au v tees 33 Analy Zing With Migros Of Ex CCl TEE E TOO OO OU ic Um 34 E Xtra Culhig Tie Cala ii Tc 34 Placing datami tne s preads ect icu taras fert Pose Ad e de E cate CIN I PAD vin Aid 35 A atomiatcallv buldind grebplis sounds raras 35 Dis playing Une anal YSIS Rae NU uaa etcndl asi ete tin see wvicwta as 36 Advanced Ml Lae ato gee eibi dator A en ene eee DAMM eer ee ene iS 37 CAND all OF e cr adora
12. MAS Sle PEEL 54 Ub ea che ete TTC ES 54 VMELOV MM EE A AE M 55 O A DAE EA AA ut meiden ME O bd tes Md eli Er du fidus e 55 PND SO aes eh POR Seneca reco ET EAA red A NN 55 Shortcuts In WNOTOCORDSDeI di A di bata roa ea vr vc AAA natal E v e Co ea o Llc Labo D rd axe te V a eo 56 Main WAdOW MEM mortero 56 COMAGUPALION Setup WINDOW eave cron ti sria Dat AAA A laute reu v Ru PE DA AR EVE AAA AA aoe cu ut SUE PU dpa CUR VOUS 56 CMD GO IV A A ed e e ce 56 EGGS PAP E SE 0 ce I cA I CI ree dort a nv E ert ep e RI DI MD oe a e a aceite LOCI DE timate Te I oar ican edhe 56 DIDIE 027 qot rr A M PT NUR oe UR 57 VMETOE V CUNT ITUR TR TEMERE 57 Old MESS Eire eS acca hea So xe a esce s ata ta FG Sabon pd essc hoses on p Sec sev nantes UR E ELS Mot eder 58 E P P 58 AI cadi studet di d icu i LI DM DII MICI ede ILI das MI aches LIU RI foc IE aes EU Tee EE 59 Table Of Contents Published on October 27 2011 2 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems NOTOCORD Speeding up Research Empowering Science Published on My NOTOCORD http my notocord com on October 27 2011 Home gt User Manual User Manual Get started on NOTOCORD hem main functionalities and modules with our user guides and tutorials Overview amp Key Concepts Table of Contents 1 NOTOCORD hem detailed features 2 NOTOCORD hemstructure amp
13. QRS10a module The second tab Discrimination contains optional user defined discrimination parameters for refining QRS detection Advanced Tutorials gt Calibration Published on October 27 2011 39 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Check Amplitude and Signal to Noise Ratio results on a CTD60a display Apply discrimination thresholds if necessary Then recalculate the module See examples of discrimination parameters use in chapter Improve your analysis For more detailed information on QRS10a capabilities please refer to the QRS10a reference document ECG51a module configuration The configuration window contains 3 tabs Algorithm Marks and Calculated data Figure 6 du CER properties l Algerihum Marks Calculated deta M asamuam number of relenence beat bo ideni ucc 1a properties Algorta Masks Calculated data ECGS 141 properties Algorithm Maki Calculsted date Nae Nares Operations Timel Time2 PR duistie Tiel Tira ORS duration Time Time RB duran Time Tired Heart Aste BD i Tasa Timac A Peak OAS Stat Mama AF durston R Peak E GAS Erd T Ered Min OT durat EO PR dason dU Typical eese durar Algorithm tab Applies a preset for your species Parameters are used to adapt the analysis to the signal to define the boundaries of the beat analysis window Marks tab The main marks are already listed gt
14. Started gt Displaying signals Published on October 27 2011 24 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Hold down the Ctrl key click one of the graphs and drag the mouse sideways the 3 numbers displayed indicate the width of the zoom region selected its starting Pe pa point on the xaxis and its end point on the xaxis din a graph When you release the mouse all the graphs in the display window will be zoomed accordingly nd el Hold down the Ctrl key click the xaxis the cursor turns into a closed hand and dioc dex drag the cursor towards the right time scale expansion or towards the left time r scale compression axis Notes 1 The left limit of the time scale remains fixed 2 You can also use the following keyboard shortcuts Ctrl expansion or Ctrl compression In this case potential signal scrolling is not interrupted Y axis scaling Button Shortcut Actions Illustration Y axis scaling button Ctrl Y Click the graph to be scaled two thick borders will appear then click the Y axis scaling button Note Important When a graph does not show up in the display window y axis scaling may be required the graph may simply be out of scale To scale all the graphs in the display window click the Y axis scaling button twice not a double click Vertical zoom Shortcut Actions Illustration pea a endl fia drop the graph p l Only the graph selected will
15. Started gt Displaying signals Published on October 27 2011 29 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Using event markers Table of Contents 1 Basic principle 2 Configuration 3 Display Basic principle Event markers are used to identify specific moments in the course of an experiment such as the injection of a compound at a given time Event markers can be set by pressing either a function key F1 F2 F3 F8 each key corresponding to an event marker channel Or after an acquisition by 1st navigating to desired area and then right click on the mouse and select Insert marker Each event marker has a type and a label associated with it Event marker types are used to distinguish between different types of events For example type 0 may correspond to events concerning the injection of a product and type 1 may correspond to events involving observations Note The default event marker type is 0 Event marker labels are used to specifically identify marked events Configuration Setting up the KBD30a module In order to specify and make use of event markers the KBD30a module must first be set up Set up the KBD30a module in the Configuration Setup window Note Important A Configuration Setup window cannot contain more than one KBD30a module Choosing the number of event marker channels J0 JOa praperciizr Data M ull i 251051 Sidor 1 kED Xm E abu dol XR Cod m det
16. The blue zone in the upper continuous display Figure 15 represents the portion of signal displayed in the 2D 3D chart This blue zone is synchronized with the 2D 3D chart For example if you increase the number of beats displayed in the 2D 3D chart then the size of the blue zone increases If you go through the signal using the 3D view the blue zone moves simultaneously O pe aw WM Here is a non exhaustive list of basic actions to perform using the different views gt To visualize marks on individual beats and navigate from one beat to another use the 2D Editor view Figure 16 and move from one beat to another with the left and right keyboard arrows A OO c E P a Display 171 tk gt Ting fet 41198 Reference beats Left 1 Right 2 k A ORS Stat 4000 R Peak uU z ORS End T on amp a 2D Editor 2400 J 1600 i ae V1 l um pomme 3D View 160 ms amp 0 me Os 80 ms 160 ms 240 gt To visualize and or edit reference beats use the 2D Editor view Figure 16 and move from one reference beat to another with Previous and Next reference beat buttons or by using the up and down keyboard arrows gt To measure PR or QT interval duration use the Topography view left click on the graph and move the mouse to make the dimensions appear See Figure 17 200 Beas 4 tt O Ooee iL s Pag i 17430 gt To geta whole signal overview use the Topography view right click
17. Will be installed on local hard drive Then click on the Install button rs HO TOCORD hem Evolution 4 2 0 737 Setup Updating System The leatures you selected ae currently beng installed i NOTOCORD hem Evolution 4 2 0 232 Setup NOTOCORD hem Evolution 4 2 0 232 has been successfully installed Click the Frish button to exit this installation Click on Finish to close the window To complete the final stage by installing the license go straight to the next part License installation Setup Software Installation Published on October 27 2011 15 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems License Installation Table of Contents 1 General principles 2 Hectronic license 3 Diskette license 4 Support Questions General principles NOTOCORD licenses installation is done through the TokenManager application TOM supplied with the software installation CD Rom TokenManager allows the software Rights of Use management for licenses installation uninstallation from a floppy disk or an electronic file There are 2 types of NOTOCORD licenses Electronic license NOTOCORD license supplied to the customer as a lic file and requiring an activation key to be installed on a workstation Diskette license NOTOCORD license supplied to the customer as a protected yellow floppy disk Please refer directly to the chapter concerned by your license type Electronic license What do yo
18. be zoomed Ctrl key drag and Hold down the Ctrl key click the y axis and drag the cursor upwards drop the y axis expansion or downwards compression Notes 1 The lower limit of the y axis remains fixed as far as possible 2 You can also use the following keyboard shortcuts Ctrl expansion or Ctrl compression Zoom region selection Shortcut Actions Illustration Ctrl Shift Hold down the Ctrl and Shift keys and use the mouse to select the region of the keys graph to be enlarged then release the mouse the numbers displayed indicate the I rectangle dimensions of the region selected and the coordinates of its top left corner Note The width of the region selected is applied to all the graphs in the display window Zoom command button Button Action Illustration A ay lu t Right click this button to select the type of zoom command to be applied Type of Zoom Illustration Get Started gt Displaying signals Published on October 27 2011 25 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Horizontal zoom applied to all graphs Vertical zoom applied to selected graph Rectangular zoom horizontal zoom applied to all graphs vertical Zoom applied to selected graph 2x zoom 200 zoom applied to both X axis and y axis of selected graph a al Ql Ei Select the type of zoom command to be applied your selection will be stored
19. from magnetic optic disk writable DVD or recent online archiving system SAN may be used Contact NOTOCORD customer support for more information Power supply Power supply failure during recording session could crash the PC and provoke loss of data Uninterruptible power supply devices are strongly recommended Setup gt System requirements Published on October 27 2011 8 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Software Installation Table of Contents 1 Requirements 2 Start the installation 1 Exit installation 2 Carry on with installation 3 Choose the destination directory 3 Select your type of installation 1 Standard installation 2 GLP Environment installation 3 Qustominstallation Requirements The requirements for installing NOTOCORD hem Evolution are Acomputer corresponding to the recommended material requirements for the intended type of experimentation and use Refer to the document System Requirements Foran acquisition station cards and drivers must be installed and functioning before NOTOCORD hem installation in accordance with the manufacturer s recommendations The NOTOCORD hem CD ROM The license used for the station either electronic license supplied as a lic file or diskette license supplied as two yellow floppy disks The user installing NOTOCORD hem must have all the administrative rights for the machine Microsoft NET Framework 2 0 software should be i
20. from one marker to the next one belonging to the same marker channel Ctrl Shift M Navigate from one marker to the previous one belonging to the same marker channel VME10e v Shortcut Action Inserts P Start mark at cursor position Inserts QRS Start mark at cursor position Inserts R Peak mark at cursor position Inserts QRS End mark at cursor position a0 Doo VU Inserts T End mark at cursor position Appendix gt Shortcuts in NOTOCORD hem Published on October 27 2011 57 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Old user manuals User manuals related to older NOTOCORD hem versions are available below 3 5 2003 version 4 2 2007 version 3 5 2003 version User manual of the NOTOCORD hem 3 5 version 2003 Old user manuals gt 3 5 2003 version Published on October 27 2011 58 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems 4 2 2007 version 4 2 2007 version Old user manuals gt 4 2 2007 version Published on October 27 2011 59 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Source URL retrieved on October 28 2011 htto mynotocord com node 2 Old user manuals 4 2 2007 version Published on October 27 2011 60 60
21. grade Entry level workstation workstation or workstation or Workstation Workstation CPU usage during Values when running the lt 50 lt 50 lt 50 software extracted from acquisition Task Manager program Values when running the Memory usage lt 50 max available lt 50 maxavailable 5096 maxavailable software extracted from Task Manager program Number of processors 1 1 1 When using external RAM 1024 Nb gt 2048 Mb 4096 Mb en technology 2GB is recommended See Data Acquisition PCI PCI Express USB Yes Yes Yes Hardware Supported below Hard Diskee nirller gt SATA II with RAID matrix gt SATA II with RAID gt SATA II with RAID 0 matrix 0 matrix O or SAS gt 200 GB gt 10000 Secondary local storage Disk capacity gt 200 GB gt 7200 rpm gt 300 GB 2 7200 rpm rpm with a secondary recommended for large storage with gt 400 GB files handling Only for legacy install uninstall using floppy disk protection before July 2008 Floppy disk See comment See comment See comment Setup gt System requirements Published on October 27 2011 6 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Network interface Graphic interface Graphic dedicated RAM Multi monitors CD ROM reader Uninterruptible power supply Surge protection Operating system Microsoft NET Framework Disk file system User privileges for installation User privilege for running Free space for
22. n 4 SEUD Aider neraties ive AT wnat ere renin dc vbt RI Cf ELLO ruta vec omar cere vp airs Eder Ac nrbt reta 6 System require Ments iu sderieroredeadts eiectus dan cou SUIT Dus laxa thats oU data qot tese crest sU es ecu Sue awe cupa Nb Ce ce Fea Ve reto Cu LSU meen ew Uere PORC rU euo aaa du du bCR Ue UM Ec Le aa 6 PIS CHANING IR at t cr 6 General CONSIderationS mca MP E DE t 6 Pe contdgurablofis tac Dessous Sebbene tuse db ce aduer cerva dm EL C Ep Rd nurs cue a aa alent asl a Aetas corset ode omm te bm oe 6 Data Acq isition Hardware Supported iiu io oir im unda ti er aE ASEPE act cus us oven deala a e Aa aaa E a Taada aeS Iu darias boe 7 PODS hE E va E A E EET TA ia 7 SONWANE a e ona E A a UEd 9 RequiFements scout dat anna lo ol o T a a o a e ooo a aaa aia 9 Start the INS tallatliON rss A O A EA A a A AR CO 9 Select vour type OluNS tall dto Naiara lacio 10 Heens e TOS Talan ne a dias 16 General PANCIDIES E E RE E 16 Electromia MOENS RN TIS DIL TED DID DOLLER 16 Diskette A A AE ADAE 19 SUPPO QUESTIONS 2 E E RER IM EI IS d II MIL EIL FK MINIMI LIII iU EEE 21 CIN MON We MEE TU CITUR 22 COnN ACAS ITON aaar AE A a a EL LR T 22 Display a d config ration WINGOWS isir ee a ae pd D Ea I LM aaa Aaa LANA M RM I EM E RE 22 Module Conng ura Mari T tm 22 Displaying signalS iia A AAA e aea bte i oe uu aL Toei 24 Starting the acquisition PECES tmb Saeed serous saves cot MIEL II LP A MAII II DEM due een M INE
23. nex signal analysis The number of beats to displayis too low to overview the whole signal The display will be setto 1 1000 ECG input frequency must be between 100 Hz and 5000 Hz No data on x input QT duration Mn parameter must be lower than QT duration Max parameter PR duration Mn parameter must be lower than PR duration Max parameter Typical R wave duration parameter must be lower than PR duration Mn parameter Duplicated shortcut The name of a mark is missing The name of a calculated data is missing Operation field of x output is empty Appendix Error index Cause Reference beats marks properties parameters ECG input or trigger input have changed since the last Signal analysis Output results may not be consistent with the current state of the module The message appears when clicking on Signal overview if the N Beats would implythe parameter Display 1 n to be higher than 1000 Then the parameter n is set at 1000 Identify reference beats Apply marking or Analyze signal were run with an input ECG signal outside of the supported acquisition frequency range Both the ECG and the QRS inputs must be connected since they are mandatory inputs QT duration parameters in the Algorithm tab of the properties window are invalid PR duration parameters in the A gorithm tab of the properties window are invalid Typical R wave duration parameter or PR duration Mn parameter is invalid Several marks have s
24. on the chart area and select Signal Overview It automatically adapts the Display 1 n parameter in order to spread the chosen number of displayed beats Beats over the whole signal Figure 17 and Figure 18 The Signal overview option in Topography view is convenient for setting the parameters in the ECG51a properties window before the analysis To exit signal overview decrease the Display 1 n parameter and select a beat of interest on the Continuous Display by choosing Show beat in the right click popup menu 100 Beats Ii p Display 17235 a gt To move the whole graph in the 2D 3D chart area right click and simultaneously move the mouse gt To select a particular beat on the graph use Ctrl click on the beat of interest This beatis highlighted as shown on Figure 19 This active beat is also designated in the Continuous Display by a purple arrow underneath see Figure 3 showing its position in the whole signal Advanced Tutorials Calibration Published on October 27 2011 42 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems e manc os Gee C o Gee 0 nz T Improve your analysis Improve QRS detection QRS10a detects QRS complexes and can be used to trigger ECG51a analysis Wrong QRS detections can be filtered out using the Discrimination tab of QRS10a properties Remove noise and artifacts detected as QRS complexes using QRS amplitude parameter OFS Sinem m ar e EN DNS
25. rate e Sum of sampling rate for each data flow For example 8 x 1000 Hz channels 8 filter modules will produce about 8x1000 8x1000 16000 Samples s e An approximate coefficient of 1 6 bytes can be applied To know the number of bytes per second the former value must be multiplied by 1 6 For example 16 000 1 6 25 6 KB s e 92 MB hour Value 1 6 depends on signals form compression algorithm 1 6 is an average value With video recording enabled file size is a function of number of video channels number of images s image format real time compression quality color or black and white images sound simultaneously recorded and activity of subjects during recording As a ruff estimate size can be 33Mb hour for 1 video channel no sound 25 frames s 320x200 frame size CIF low quality compression Medium quality and High quality are respectively 80 Mb hour and 180 Mb hour For more details please refer to the specification document for video data acquisition server Setup gt System requirements Published on October 27 2011 7 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Local disk capacity We advise you to have a local disk capacity that allows keeping all online experimentations included in the study For maintenance reasons the capacity must be multiplied by 2 Data backup Different strategies may be used depending on the volume of experimental data GLP 21CFRPart 11 compliancy Media
26. temp storage Spreadsheet Antivirus and other background applications Yes 2 100Mbits s External to CPU Chipset PCI Express PCI Express 2 256 VB dedicated RAM 2 1280x1024 resolution per screen 32 bits color coding 96 dpi font size display 21 Recommended XP Professional SP3 gt v2 0 NTFS Administrator Simple user 2 2 GB Microsoft EXCEL 2003 XP and 2007 No Yes 2 1Gbits s External to CPU Chipset PCI Express PCI Express 2 256 MB dedicated RAM gt 1280x1024 resolution per screen 32 bits color coding 96 dpi font size display 22 Yes XP Professional SP3 2 V2 0 NTFS Administrator Simple user 2 2 GB Microsoft EXCEL TM 2003 XP and 2007 No Yes 2 1Gbits s External to CPU Chipset PCI Express PCI Express 2 256 MB dedicated RAM 2 1280x1024 resolution per screen 32 bits color coding 96 dpi font size display 22 Yes XP Professional SP3 2 V2 0 NTFS Administrator Simple user 22GB Microsoft EXCEL 2003 XP and 2007 No Table 2 Recommended PC configuration Data Acquisition Hardware Supported For GLP 21 CFR part 11 environment and 2 1Gbits s for high volume transfer Multi monitors function is useful for great number of channels DO NOT USE INTEGRATED GRAPHIC CONTROLER WITH CPU CHIPSET see Appendix note For software release installation Networked drive is compatible For access rights file permissi
27. the LifeShirt name gt LifeShirt that is not available No LifeShirt defined on this computer Unable to perform Calibration of another LifeShirt is in progress Appendix Error index Cause When inserting the module in the configuration window with no TMS device currently connected Offset exceeds limit values defined bythe signal type and range Cause LifeShirt device defined in the configuration of the module is not available Calibrate and OK buttons are grayed This message disappears when an available device is selected in the combo box No LifeShirt device has been configured on this machine Another calibration is in progress and has to be completed before the launch of the calibration process for another Lifeshirt For the selected LifeShirt the configuration of the channel in the Published on October 27 2011 54 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems LifeShirt is in acquisition with a different calibration Click here to get the calibration from the acquisition VME10v Message The reference marker was not found The Markers input not connected The beginning of the zone does not belong to an acquisition period The beginning and the end of the zone do not belong to the same acquisition period Not enough R peaks detected to define zone Zone duration not defined No input signal detected Input not connected or no acquisition period The zo
28. the Zone X Appears when accepting zones definition Cycle definition is based on end diastole detection Zone X does not have a minimum of two end diastole data points necessary to proceed with the loop analysis Appears when accepting zones definition A leasttwo analysis zones are overlapping Appears when accepting zones definition Analysis zone contains too many samples Appears when accepting zones definition Inappropriate sampling rate Appears when accepting zones definition Parallel conductance volume computation is uses the linear regression fitting the Ved Ves or Vmin Vmaxrelationship Two complete cycles are therefore necessary to obtain the linear regression User does not have sufficient permission on the destination folder or there is not enough disk space available Appears when saving the current analysis zone as a control one pv User does not have sufficient permission on the source folder Appears when loading a control file pM in the nss file Error code Exclusion origin 0 Events excluded by algorithm 1 QRS amplitude Lowthreshold has not been reached 2 QRS amplitude High threshold has been crossed 3 Signal to Noise Ratio Low threshold has not been reached 4 Signal to Noise Ratio High threshold has been crossed TMS31a Message Cannot launch TMS server Check acquisition hardware and software setup The offset must be within mV VIV10a Message This configuration requires
29. use the Add mark option Figure 11 Click on the Next button to move to the next reference beat T NC ear LL M Oli m m A oe A em IT T ai nnus amp 7 Ei Rs Fig gel terna Dar ul a re z a Ea vu Pp xm ate al Tapore End Perra crinem bee E D ves um D A o Sat Sed yt bona ny EI n 3 bd sor Daria tr um rid n rii LEE pif apa stame a Ld T or Ld gt Apply marking option for facilitated marking e Use the Apply marking button to mark the active reference beat Figure 12 This function compiles all existing reference beats marks in order to automatically mark the current active reference beat Add any missing mark and or adjust the marks e 1 18 ec Marking mode When you press ctrl click on the Apply marking button the button remains in an active state providing a pre marking for each visualized reference beat There is no need to click on the button for each beat Tips gt If you hesitate on how to position marks correctly T End for example here are some ways to help you out You may check the QT duration value of the current reference beat in the statistics table You may check the neighboring beats by clicking on the 2D 3D chart to activate it and then by navigating between beats with the left and right keyboard amows gt Ifa dash appears in front of the number of reference beats e g 18 then the active beatis not a reference beat Move t
30. where they wil be installed Recommended for advanced users In order to limit access to files produced by NOTOCORD hem held in the workfile directory the two following steps must be taken Aspecific Windows user account will be assigned to secure NOTOCORD hem data access You will be asked to enter this account when filling up the Data Manager Account window Figure 10 Specific NTFS rights will be applied to the workfile directory to allow the NOTOCORD hem to work with this directory The installation program will do it automatically Setup gt Software Installation Published on October 27 2011 11 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems ie NOTOCORD hem Evolution 4 2 0 232 Setup Whorkfile Directory cli Selecta workhle drector where data wll be stored Files created by NOTOCORD hem Evolution 4 200 222 vell be wither in Gis directory Workile Director 5 Shared by all users C Program FlesiMotocordi Data O Mp Documents custom directory hor each user The GLP Environment installation starts by selecting the default workfile directory where data files produced by NOTOCORD hem will be written When working in a GLP environment we recommend to choose the Shared by all users option for workfile directory The directory proposed by default is C Program Files Notocord Data Comments By selecting the default workfile directory shared by all users Notocord
31. 1 5 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Setup System requirements Recommended PC configuration for using NOTOCORD hem Evolution version 4 x Table of Contents 1 Disclaimer 2 General considerations 3 PC configurations 4 Data Acquisition Hardware Supported 5 Appendix This document aims to provide a NOTOCORD hem user with a list of characteristics and recommendations for the configuration of the computer on which the software will be used The user s requirements will then guide the choice for a standard or an advanced configuration Video data acquisition requires a dedicated computer configuration including more advanced hard disk and graphic card features Recommendations will be given in a dedicated paragraph Disclaimer Due to constant technological progress the information in this document cannot be considered as part of any agreement between NOTOCORD and users Information hereafter may be modified by NOTOCORD without notice As software errors may exist in drivers firmware as hardware manufacturers may change without notice some specifications of their products itis almost impossible for NOTOCORD to predict the final absolute performance for a complete system integrating a computer hardware and our software General considerations The choice of a particular configuration is highly dependent on a user s specific requirements The following factors should thus be considered carefu
32. 11 NOTOCORD Systems Get Started Configuring acquisition Focus on NOTOCORD hem configuration Table of Contents 1 Display and configuration windows 2 Module configuration Display and configuration windows NOTOCORD hem starts with the Main window displayed full screen NOTOCORD hem display two windows The Main window displays your signals raw signals and calculated data during the experiment The Configuration window is used to set up your protocol You can switch from one to the other by clicking the corresponding top left icon or by pressing simultaneously Ctrl key and space bar Switch ho Llosa configuration window HOTTCK ORD hem f John Seth ren A E eb Switch te main Hide configuration window Lonlgurati Setup _ E E s dia exci DODi1D CEOs bids i i 1 DTT its Note You can resize and arrange the two windows so as to view them together and easily switch from one to the other Module configuration Introduction Default modules NOTOCORD hem comes with four default modules NSR10a Acquisition module employing data previously saved as a NSS file Note that NOTOCORD hem generated data files are identified by the nss file extension It allows you to simulate a previously performed acquisition In order to help you learn to use the software the NSR10a acquisition module has been preconfigured to read a simulation file loaded at startup containing ECG and ABP signals CTD60a D
33. 25 Recalculate the module Advanced Tutorials gt Calibration Published on October 27 2011 43 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems 051041 properties Aligonthm Discrimination QAS amplitude LI Low thread 7 High threshold 5 DRAS Signal Ea Hoise Ratio SHR CTI KOE 7 High threshold ag zi Enable a criterion and adui the uses threshold to detechons produced on he OFS output Lox Cima Check the results on Figure 26 New QRS output is displayed green Rejected QRS complexes are stored in the Abnormal detections output of QRS10a and removed from the QRS output used to trigger ECG51a analysis Limit analysis to a specific zone of interest On Figure 27 ECG signal and detected QRS complexes are displayed on the upper graph QRS Amplitude and QRS Signal to Noise Ratio outputs are displayed on the lower graphs ie HOTDCORD Hem PIE DUDAS TAL TION PURPOSE 0 Pie F r aton Took ro Hep 2 HUX epa ms 13000 4 Ifyour ECG51a analysis should be performed on a specific zone of interest you can recalculate the QRS10a module on this zone alone e Click on nsert a vertical zone and place the analysis zone Right click on the zone Select the Properties option and set the zone width and onset Select Recalculate parameters to recalculate QRS10a module on the zone alone Warning calculations outside this zone will be lost except for calculations
34. BT3 6 acquisition up to 7 14 devices DSI60a b c d DSI OpenART 4 8 12 16 sources acquisition server DTS60a b DataTranslation card 16 32 analog channels acquisition server INS30a GW Instruments Instrunet acquisition server MPI10a Matlab Link for NOTOCORD hem OHA10a Ohaus Adventurer balance server PRT30a Continuous thermal printer AR200 driver TMS31a TMS acquisition server VIV10a Mvometrics LifeShirt acquisition VSH10a b 4 8 channels video acquisition server Custom Tools Customized Notocord tools Legacy Tools Tools from older NOTOCORD hem versions LMG10a System ensuring security of video data streams MON10a Remote monitoring of video data streams Third Party Tools Non Notocord developed softwares Do not hesitate to ask yur NOTOCORD contact person for confirmation of the features you need to install in regards of your license To select a software feature i NOTOCORD hem Evolution 4 2 0 232 Setup Select Features e ES Please select which features you would like to install Je NOTOCORD hem Corcience BT 2 6 acquisition up to 7 14 devices Wil be installed on local hard drive EMI Entre feature wil be installed on local hard drive Entire Feature wil be unavailable Cimes Setup gt Software Installation Published on October 27 2011 14 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Right click on the feature to install Click on
35. NOTOCORD Speeding up Research Empowering Science User Manual NOTOCORD NOTOCORD hem Evolution 4 2 0 297 NOTOCORD Systems SAS My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Table Of Contents TS OT Cs OS ES Sesser LUI UNLLMUTUUT P 1 User diii RR T E tsb nh ae ee cee ceca tena PM 3 Overview Key CODCSDLS iaeiei iat cede denk a paid auod E E A Suche damen dad qe Lime UA Coda ps Ao dU Ud pedo dou eid addu bs olco ad 3 NOTOCORDsShem etalled fedes ms etn AAA e abc code Dod uie D dug tal ra A zi OL HONO muna eid asd E Er vi cuo E DOE E eaten 3 ACOSO Mem nn c 3 Data anablysis Ce he VN Wore med editi ttu Ups e VERE EUER A A eae adea rut denned nee ere on cO ut ee eee eee 3 DIS play cert iine EM M MIU IM aU II TRA 3 RGDOFE 22090 iret ste cae tek icse cetus une me etos sou teme Lem M Cd o SUAE a a D DM DS IM Ie I DI Nt LII DULL DID pU SO ope os coto ta OL a c I Den DOE co En a 3 NOTOCORDshenrstructutre amp Operating Mode 65 1c daa ls aeta a des Pura a wA CUR LUPO P du HE HOUR DU NE ean 3 Components ce P UC CT RT bats a intestate eae cee 3 EOS ie Sats te ETE taa T 4 UsingNOTOCORDADIGIT esses ide ii ded 4 Main steps for configuration and data analysis with NOTO CO RD hem scessseseeneen nennen nne nese esses anes sneak suas aas k usns saa sau saa su sna sau saeua sna na sun
36. OTOCORD hem Evolution AccessManager LabManager TokenManager Ses Modules Excel Wizard add in x3 Microsoft Excel Data Manager Hardware N55 Files e Active Directory Domain Controller Operating System Infrastructure Services User Authentication User Right Management Environment NOTOCORD hem is compatible with various acquisition devices It interacts with hardware and acquisition cards to retrieve the information to analyze Each generated file contains data and the configuration NOTOCORD hem operates in the Microsoft environment including Windows XP and Active Directory Using NOTOCORD hem The application consists of two main windows The configuration window showing the links between selected modules and the various parameters specified The main display window showing various data display and analysis tasks performed by display modules 7 000 CA ames da a ara rupem Hemden A Lega led auda 4e dE 4a 48 A8 2 A rM gU m ia Xd COG LC de rd Ge o GNIYR o i Maldad palas e irs learre rain ur Main steps for configuration and data analysis with NOTOCORD hem Configuration Acquisition server Selecting channels of interest and assigning an acquisition frequency to each one of them Processing analysis modules Selecting processing analysis module of interest setting up parameters for each module and linking complementary modules to creat
37. Oct 11 NOTOCORD Systems B peak timai T eri L min Time 13405523 122 754 1341 058 151 150 134152 134 3060 12114 1542 1180 Lely 528 192812 7640 1343 008 1543 2120 13421433 15233 8300 13 E24 1523 2500 1344 2 13214140 Ln nag aWu 1344 SL LUI 1345 228 ma Corral neler Free 135533 N A 135 533 LOS cms N T aral detection for hase beats Diac elon annd sez after peak time Durssen after lee A 116278 N A Lus sr Te 3120 1345 973 1347 8 E20 1347 34 LT 1347 654 LLLI 13545 054 ana Range of LHE 133 WA redare ca imas 1 LME 782 1383 3700 144 12 1243 3100 145 493 my 1354558 LOT 1150 14 112 1880 IEEE 10 7850 1350 554 1351 8620 Advanced Tutorials PV Loop Published on October 27 2011 48 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems PV Loop Guidelines on volume signal management and Baan s equation application Table of Contents 1 Introduction 2 Volume signals connection to PVL10I module 3 Baan s equation application 4 References Introduction This tutorial provides guidelines on volume signals management and Baan s equation application As a general rule for any module recalculation must be done after each step in order to analyze the right volume signal Volume signals connection to PVL10I module Connection of n volume signals to the PVL10 volume input is achieved using n 7 OPR10a modules simple arithmetic operation between 2 si
38. Operating mode 3 Using NOTOCORD hem NOTOCORD hem is recognized as the most advanced software able to acquire analyze amp visualize life sciences signals and report quickly and efficiently into Mcrosoft Excel Our validated solutions are fit for all Safety Pharmacology Toxicology R amp D Universities and Clinical research with proven analysis capabilities for cardiovascular pulmonary electrophysiology in vivo amp in vitro signals NOTOCORD hem offers a powerful software platform hosting over 120 modules and applications ranging from acquisition to signal processing analysis and display Main Key Features Acquisition and analysis with modular data flows Over 1000 measurement channels Simultaneous acquisition from different sources and systems Interactive review while acquiring Online analysis display and data review Interactive and advanced display capabilities Data storage in one single file up to terrabytes Unique streamlined reporting process into Microsoft Excel Designed to meet GLP amp 21 CFR Part 11 rules NOTOCORD hem detailed features Acquisition Compatibility with main hardware on the market Buxco Corscience Data Translation PCI and USB AID cards DSI Hugo Sachs Electronics Millar Instruments TMS International WPI devices Fast set up for data capture and analysis Flexible parameters adjustment Easy insertion of comments and markers while recording Generation of a single file including al
39. Segal to Mona Ham bow itai O tg rca E rabia an and adiit the Prado veras desertor peace rs e AE ll CA Coen j In Figure 20 ECG signal and detetected QRS complexes green are displayed on the upper graph QRS Amplitude output is displayed on the lower graph Noisy beats can be rejected from QRS output by using the QRS amplitude parameters of QRS10a Discrimination tab Apply a Low threshold equal to 200 in this example for the amplitude Figure 22 Recalculate the QRS10a module Check the results Figure 21 New QRS output is displayed green Rejected QRS complexes are stored in the Abnormal detections output of QRS10a and removed from the QRS output used to trigger ECG51a Remove noise and artifact detected as QRS complexes using Signal to Noise Ratio SNR parameters On Figure 24 ECG signal and detected QRS complexes are displayed on the upper graph QRS Signal to Noise Ratio output is displayed on the lower graph Noisy QRS can be rejected from the QRS output using the SNR parameters of QRS10a Discrimination tab Tip To check the threshold is appropriate for the whole signal add a horizontal line on the display by double clicking on the Y axis Figure 23 E HOTOCCORD Hem FOR DEMONSTRATION PURPOSE ONLY LLLMECG mese ms gt le OIX O Fe dk Acgusbon Took Widow Heb FX 0O Graph properties da m CA BE E e Applya Lowthreshold equal to 4 in this example for the SNR Figure
40. Tutorials Calibration I s Published on October 27 2011 46 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Excel Time matched extraction wizard How to use the Time matched extraction wizard in Microsoft Excel Table of Contents 1 Overview 2 Exact matching mode 3 Time matching window mode The time matched extraction wizard function has been added to NOTOCORD hem in March 2009 and is available with version 4 2 0 230 onwards e Pe Home Invert Page Layout armmular Data Ege EIL laredo per Overview The time matched extraction wizard allows the extraction of data related to a range of reference time points Time is always the reference and the data can be of the following types values durations and counts There are two possible extraction modes Exact matching the software retrieves the data at the exact time defined by the reference time point Application example Beat to beat analysis Eg The range of reference time points is defined by the R peaks and the selected data is QT duration The extraction wizard retrieves the QT interval value related to each R peak If there is a detection issue eg no T end detected then cell data for the QT interval shows N A Time matching window the software retrieves the data in a time window specified by the user in second before and after the reference time point There are 4 options for result displ
41. a 7 KED Wi Even misce Double click the KBD30a module to display the KBD30a properties window Enter the number of event marker channels required in the Number of channels field Note that onlythe first eight channels are connected with F1 F2 F8 Several different combinations of event marker channels types can be used depending on the way you like to work and the nature of the tests to be carried out For example you can assign one event marker channel per animal and specify the operations carried out using event marker types You can also assign an event marker channel for each type of operation and use event marker types as an additional means to distinguish between various operations KBD30a module outputs After you have clicked OK in the KBD30a properties window the amount of KBD30a module inputs and outputs will correspond to the number of channels assigned The inputs remain on standby They are used in association with event marker channels activated by either a pushbutton or a function key Outputs can be connected to display modules so as to View the corresponding event markers Note An event marker can be viewed in any graph independently of the signal it is assigned to i e an event marker channel associated with a given signal can be displayed in a graph corresponding to another signal Display Set up the following configuration Event marker channel 1 is assigned to the ECG signal of the NSR10a module
42. an bo linpp nix i Unial cerco Click on Install license from floppy disk Select in the TokenManager upper grid the tokens you want to install Click on nstall The new installed modules are now vsible in the TokenManager lower grid window Close the window the update is effective Remove the floppy disk from the floppy drive Keep it for further uninstallation of the license on this computer Support Questions What can you do in case of Computer crash mother board hard disk system with an electronic license was installed on it Contact NOTOCORD Customer Support to desactivate your license Then you can reinstall it on another computer Computer crash mother board hard disk system with a diskette license was installed on it Use your Backup floppy disk Then contact NOTOCORD Customer Support to have a new Backup floppy disk Loss of your lic license file Contact NOTOCORD Customer Support your lic file will be sent again No reception of the e mail containing the Jic file Contact NOTOCORD Customer Support to check the validity of your e mail address No reception of the e mail containing the activation key Contact NOTOCORD Customer Support to check the validity of your e mail address Regarding the origin of error messages please refer to the Licensing reference document Setup License Installation Published on October 27 2011 21 60 My NOTOCORD User Manual Printed on 28 Oct
43. and click on Next i NOTOCORD hem Evolution 4 2 0 232 Setup Whorkfile Directory od Me oe Select workhle drechor where data wall be stored Files created by NOTODORD hem Evolution 4 20232 vall be winlben in his directory okie Director Shared by al users C Program FilezWotocondLD ata My Documerts custom directory for each user Sub drectonyr Motocard The Custom installation starts by selecting the default directory where files produced by NOTOCORD hem will be written Choose individual user directories so that each user can save his her data in his her personal directory The default directory used by NOTOCORD hem corresponds to a sub directory called Notocord in the My documents directory of the user who opens the Windows session You can type the name of the sub directory of your choice in the Sub directory box Choose one shared directory for all users to allow the files produced by NOTOCORD hem to be easily shared regardless of which user opens the Windows session The workfile directory proposed by default is C Program Files Notocord Data Setthe GLP mode When working in a GLP environment we recommend to choose the Shared by all users option for workfile directory Click on Next The installation program displays the screen for selecting the Windows account assigned to secure NOTOCORD hem data access and to set the relevant NTFS rights for the workfile directory Setup Software Installat
44. ast OPR10a module used to sum up all segment volumes and the PVL10 module Figure 3 Advanced Tutorials gt PV Loop Published on October 27 2011 49 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems LV Pressure LV Segment 1 aL Segment 2 OPR10a1 LV SEgment 3 Operation Qui LV Segment 4 LV Segment 5 OPR1084 laa Lv Volume a Event markers 1 aEvent markers 2 Addition av br2 C2 Multiplication a Y2 CO Division arer Output domain Output domain limitation Upper Limit Lower Limit Held correction factor application As the electrical field for measuring conductance is not uniform 1 a field correction factor a must be applied to extract the true ventricular volume following Baan s equation V 1 a x pL G measured G parallel Vis the ventricular volume ais the field correction factor pis the blood resistivity Lis the length between the sensing electrodes Gis the conductance If a is commonly assumed around 1 for a one segment catheter and therefore for small animals a multi segments catheter actually requires to estimate this correction factor The a field correction factor is assessed during a ventricular steady state as the ratio between the Stroke Volume SV estimated with the multi segment catheter and therefore PVL101 module and the SV estimated with another measurement technique i e blood flowmeter thermod
45. available are Default Loads the saved configuration as the default configuration refer to the next paragraph Memo 1 Memo 2 Loads the configuration assigned to the Memo 1 Memo 2 button see below for a description on how to assign a configuration to one of these buttons Current Retains the current configuration Empty The configuration window is clear of all modules More Loads the selected configuration Saving the current configuration as a Memo You can save the current configuration as a base for working on other experiments The first method described above includes saving the configuration under an explicitly entered name and calling it back up during other experiments The second useful method is to record a configuration as a Memo which remains available and specific for each user To assign the current configuration to a Memo button hold left mouse button pressed on one of the toolbar M buttons until the color becomes red After releasing the mouse button the Memo button number turns from white to red This indicates a configuration has been assigned to this particular Memo button Once the current configuration has been stored in a Memo it can be called back in any application by simply clicking on the corresponding button Note To assign a name to a M emo click with the right mouse button on the corresponding e n t E button and select the M emo editing box The name entered will be displa
46. ay First value provides the first value in the specified time window Last value provides the last value in the specified time window Closest value provides the closest value to the reference time given Mean of value provides the mean of all value available in the specified time window Exact matching mode The wizard function uses the same principle as the standard extraction 1 Extract your range of reference time points 2 Select the file and data you want to extract 3 To define the reference time points select in the Excel table the time range for which related data will be extracted ensure the whole range is selected 4 Choose the output type value duration or count M piah terri Tira riche nin ar Hp x D HL DES gt Hil a m 343 134 prim In H1 po LER 113 E24 D Imn di 24 1444 51 mayra 1315 328 mua Mo Tn detection icr 1H5 M PI E ihesebeats Pee wa 1328 TM CALE zm 144 571 IM i347 hi ai IH 8 IHA HIIDH ii 133 15d Par bi Tig e 198 12 1 Ranged TUE reterenrce Times iii EHE maya Time matching window mode 1 Unselect the Exact matching option and fill in the Parameters of time matching wndow 2 Define the search window by giving the duration before and after the reference time 3 Select the computation method First value by default Advanced Tutorials gt Excel Time matched extraction wizard Published on October 27 2011 47 60 My NOTOCORD User Manual Printed on 28
47. beat A 0 D O TU Ctrl M Ctrl click on Apply marking button Ctrl Z Action Selects beat of interest on graph Selects beat of interest and brings it to front Inserts P Start mark at cursor position Inserts QRS Start mark at cursor position Inserts R Peak mark at cursor position Inserts QRS End mark at cursor position Inserts T End mark at cursor position Applies marking to active reference beat from all marked reference beats Activates Marking mode Marks are applied to reference beats as they become active General undo for mark editing and X Y zoom Ctrl Del Deletes all marks on all reference beats Right arrow Goes N beats forward N number of beats displayed in 3D Mew of 2D 3D chart Left arrow Goes N beats backwards N number of beats displayed in 3D Mew of 2D 3D chart Up arrow Goes to previous reference beat Down arrow Goes to next reference beat Page up Goes n xN beats forward n value of display 1 n parameter and N number of beats displayed in 3D Mew of 2D 3D chart Page down Goes n xN beats backwards n value of display 1 n parameter and N number of beats displayed in 3D Mew of 2D 3D chart Begin Goes to first QRS trigger of the signal End Goes to last QRS trigger of the signal 3D zoom in centered on cursor position 3D zoom out centered on cursor position KBD30a Shortcut Action F1 to F8 Inserts marker on related marker channel F9 Inserts non specific marker Ctrl M Navigate
48. cense Uninstallation Case n 3 License Transfer Case n 4 License Modification For further information please refer to the Licensing reference document Case n 1 License Installation I Check tha krami tec serial ye conquis aer rick on reis uten E E Fila HOT OCAT han Esalution kr acqueahon soci and anan of grads aden dala Ej vite Wedesines Life s hal agusto up lo d devis Beate ibe Grat nda bs Mette rra brezo E 5PE1A Sila dpi El ASPAS Herinn arial nes pa leon anuos E 01360 Dabam card 1 anadeg channel scquiahon cerca E ECEE Corocin pert idircinic andopi ani drive el Click on Install license from floppy disk Tick the boxcorresponding to the license you want to install on this computer and then click on Install The license is installed on this computer To check that your license is installed it should appear in the TokenManager lower grid Remove the floppy disk from the floppy drive Keep the floppy disk for further uninstalllation of the license on this computer Case n 2 License Uninstallation When should you uninstall your license e License transfer on another workstation Software uninstallation on this workstation License modification Uninstallation Procedure Insert your yellow floppy disk in the floppy drive Launch TokenManager Click on Refresh The TokenManager lower Zy HOTOCORD Tokendanapes B grid shows all modules currently installed on this computer T Cl ee eee ee aN
49. cense number is already installed on this computer The selected file is not compatible with license installation from file The selected license is invalid The selected license has expired since 96s MPI10a indicated for each data in the Calculated data tab of the properties window Cause For one of the activated rhythms the minimum frequency is above the maximum frequency For one of the activated sub rhythms the minimum or the maxmum frequencyis out of the defined domain of the corresponding rhythm Cause Clicking on ns all with floppy disk as a source but tokens from a lic file electronic license are also activated on this computer Clicking on Install with lic file as a source but floppy disk tokens are also activated on this computer Uninstalling key could not be achieved when clicking on Uninstall Clicking on Activate but the keyis invalid Clicking on Get key via Internet but a key cannot be generated by NOTOCORD Web Service license already activated or non existent license number Clicking on Get key via Internet but the NOTOCORD Web Service connection fails Sending uninstall information but the uninstall keyis not validated by Notocord Web Service non existent license wrong key number Clicking on ns all but a license with the same number is already installed on the computer Selecting a token file from a floppy disk during an electronic license installation Selecting a token fi
50. ck the kcaras ho rail ae computer sed click on nisl button Case n 2 License Uninstallation When should you uninstall your license License transfer on another workstation Software uninstallation on this workstation License modification Uninstallation procedure Launch TokenManager Zr HOTOCORD lokenManaper Luise milabed vs topili Chh thet Beers le uniia aed cick on Urii bution __ REMORSE TRA TOM LICENSE FOR NO TOCORDHSEH EVOLUTION TEST DAL H PROCNL nirai HDTDCDREO han E cmlubeen pour Pacqucition artapriiral el acaleca de ignea el darra i Aci ke odo GLP St 21 DFA Past 13 de NO TDDURDH ens naktas de polentel dachin cardiaque aec parada FiA Fila inmpubsora parate Filing pese irdsapcdedc bras Aches de hpa cope rece 5 instal licere boon files iina icena bore floppy cii 55 Urini al nta Click on Uninstall license and select the license to be uninstalled Click on Uninstall Setup gt License Installation Published on October 27 2011 18 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems 43 Uninstall Your NOTOCORD hem license was successfully uninstalled In order to finakze and validate this process you may choose to send the information below ether now using the Internet ar later by copying pastimg the information in an email to your Sales Representative This wall allow you to reactivate this license when needed Uniretall Information L
51. da daa arder 37 ECGGbTa JJ ORSLOSTUEtONSI di a E e A AS A P EVA TE Ede AA A in 37 I TIEPOGUC LOIN rca A as ln 38 Modules confiqtiration NOTO CO RD e aiii A AAN dea 39 ORS trigger generation With ORS 10 a module stat AA DA AA A Fun dv du O 39 S CIONES Mod le contigua Maia da A A DA AS VDD A A A AAA A A 40 ECO o e e e ls A 40 Improve yo uranalySiS e celia gu tel o Lo id seu sn D LLL MM t MM 43 Excel TimesmatehedextractomwWLIZaEG cionado eein eii e Ae a ao oi cane Teide dus ditdn tte 47 OVERVIEW mcs 47 Ea Ulla be iMAC MOC ERE DIT UU MI Tu UII TEES EE 47 Time matching WIN dOWIMOJe ses atte S Ie Lee 47 PV LEO coc 48 lWsursejolUrexute neo rep Pee RP dr eR MUR 49 Volume signals COnneetion to Py L TOL Mod issued teo xU a update a cu tt sud uxo saa damus ner tp aL cUEE E dr ud Mns Occ EE cR cud UE Eder E DEEP ELE 49 Baa s equation aPDIGaLlOMN Sl E m Em 49 PSTN OMG CS ita loa ia il aia 51 ADDENGDE its Na AS A AA peu a dc 52 EN o dd 52 ON 52 ECGS Pu AAA A A AA ES teeta a ad 52 ECOS a in TU INT TII T 52 EEG a e RE EET ELI T I NN IM IM 53 license Management anna AA A Duce ua EAS AIN A aa ade IN a I VEM De LA A AA AA RUM A ia aa 53 IY PL AO hh oec P E T aaa 53 Table Of Contents Published on October 27 2011 1 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems A I iA A D A tL nA CA n A nt E E MA A Ac E DEA anne 53 PAS O 54 CRS lt ied RC r 54
52. e Click on Load a configuration in the Configuration Setup window or use the File gt Load a configuration command e ooo 4 JM z Load configuration ECG30d FFT 30a GADD Opening a data file Be EX iiie Jods ike Hop Y data file by clicki in the Main wind by using the File gt En AE ou can open a data file by clicking on Open in the Main window or by using the File gt Open cam PO Mdb p ceres File selection window opens When a nss file is selected in the list its preview is displayed by clicking on the ad hoc menu s tab Preview corresponds to the display of the main screen as it was by closing the file XP red ERO Suerk d 1 Call CER Tarea Pack 2 Fie Qa Epia roi m Fin diya Hoscoid Filas f ne Creating a new data file Get Started Managing files Published on October 27 2011 32 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems To create a new file you can click on New in the Main window or run the File gt New command Ctra Ele Edit Acquistion Tools Wir Those D 3 a a or Print Ctrl P 53 Load configuration Save configuration Configuration Report Ext Bk F4 The opening window enables you to set the file s location and name and required configuration Save jr Ej Motocord iy E xpenmentii nes hy Recent Documents 2 My Computer Fle name Experiment nl Save as hep Molocord Files ras Canligurarsce Emgly The options
53. e Internet Click on Copy to Clipboard in order to automatically copy the activation information contained in the dialogue window You must send NOTOCORD these 4 IDs by e mail faxor telephone For that purpose contact your Sales Representative or your Customer Support Engineer You will receive the activation key at the email address given in the license order Copy and paste the activation key into the Activation Key field Setup gt License Installation Published on October 27 2011 17 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Z3 Install In order to install your license you must enter an activation key that can be obtained either now using the Internet or later by copymg pasting the information in an emal to your Sales Representative Activation Informati License number Compute name Hardware ID Install ID Please enter your actrvabon key below F708A77E 0D 36E 7D4 The button Activate becomes active Click on Activate If the action is successful a confirmation message appears The license is then activated on this workstation It is now impossible to install it elsewhere If the action fails an error message appears Please refer to the Licensing reference document to understand the cause of the error You can check that your license is installed in the lower grid of TokenManager as shown in the figure below 4S HOTOCCRI TakenWanager n E 5 Aeadatin bornaes Che
54. e a coherent system Display windows selecting information to be visualized arranging displayed data separate curves overlapping curves or numerical values selecting display mode lines crosses histograms and color for all curves setting size and position of each display window The configuration may be set up after acquisition Acquiring experimental data Acquisition can lastfrom a few seconds to a few days Asession may include several acquisition periods Accessing data from a previous zone is possible at any time without interrupting data acquisition and processing Storage of acquired and calculated data is performed during the acquisition process Analyang graphical and or digital data Data can be visualized with various display modules or specific analysis modules Continuous digital 2 D and 3 D displays User Manual Using NOTOCORD hem Published on October 27 2011 4 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Lim s uns vs 6606 ea Our Excel wizard allows fast and efficient data extraction into Mcrosoft Excel During NOTOCORD hem installation a specific toolbar is added to your Excel application interface This unique reporting system is designed to drastically reduce time needed to generate your report Its flexibility and traceability characteristics make it an efficient powerful and time saving tool nf GS Oe E User Manual Using NOTOCORD hem Published on October 27 201
55. e wizards file information data markers has a corresponding formula such as Ns Function gt File 7 parameters separated by semi colons gt Placing data in the spreadsheet Experiment data is extracted as follows Select the cell where you wish to place the data Click on the Formula wizard It calls up the following screen Click on the Select working file button Click in the field and then on the cell that contains the filename The field is then framed bya dotted blinking line The field contains the cell s absolute address Note You can also select the file using the Browse button Then click on the Select data button The Browse button calls up the window that displays the data for the selected file Select the em miti 1 required data and validate twice Simulation 2 Specify the data that you wish to extract values average minimum maximum number of points etc Specify the analysis zone duration e g a 20 second window starting 1 minute after the start of the file Ta Durston seconds 20 Out Marker O grt fe Validate the formula definition window The active cell or those that follow will then contain mn iii de the required information Note Important The cell may display the NA or ZZone error message Click on the edit wizard to see if you have incorrectly set up the formula wizard or if there is no data in the section you are trying to extract A
56. ecutive values all of the cells are changed along with the graph that may be assigned to them Note The Evaluate button displays the result of the formula applied to the zone without changing the active Excel cell Get Started Analyzing with Microsoft Excel Published on October 27 2011 36 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Advanced Tutorials Calibration Calibration tutorial Advanced Tutorials gt Calibration Published on October 27 2011 37 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems ECG51a QRS10a tutorial How to start with ECG51a and QRS10a PEE Table of Contents 1 Introduction 2 Modules configuration in NOTOCORD hem 3 QRS trigger generation with QRS10a module 4 EOG51a module configuration 5 E0G51a analysis 6 Improve your analysis Introduction This user guide is designed to help you get started with ECG51a and QRS10a modules A ECG51a demo video and reference documents for ECG51a and QRS10a are also available Basic principles of ECG51a analysis Athree step process ECG51a module is an offline beat to beat analyzer based on propagation of user defined marks typically PQRST in 3 main steps Automated Manual marking Marks propagation reference beats of to other beats identification reference beats over the signal The reference beats are file specific and automatically identified by the module step 1 To do so the algor
57. essure and Volume input signals are not sampled at the same rate in zone X Analysis zone X must include a full cycle You may recalculate the module and then check that the analysis zones are properly defined Overlapping of analysis zones is not allowed Analysis zone Xmust not contain more than Ysamples Sampling rate must be within 500 Hz to 10 kHz The zone defined for parallel conductance volume computation must include atleast two complete cycles You may recalculate the module and then check that the zone is properly defined and validated Error writing file X Check your rights on this folder and available disk space Error reading file X Check your rights on this file QRS10a Error codes for Abnormal detections output Zone Xdoes not have a minimum of two end diastole data points At least two analysis zones are overlapping Analysis zone contains too many samples Inappropriate sampling rate Two complete cycles are mandatory for calculating parallel conductance volume User does not have sufficient permission on the destination folder or disk space available is not sufficient User does not have sufficient permission on the source folder Cause One of the mandatory inputs is not connected Appears when accepting zones definition Zone Xis not entirely included in a single acquisition period Appears when accepting zones definition Pressure and volume signals do not have the same sampling rate on
58. gnals For example 4 OPR10a modules are needed to connect all volume signals from a 5 segments catheter Figure 1 By default OPR10a is suitable for summing up all segment volumes without causing any change in the properties window LV Pressure mPes LV Segment 1 Tm Ped LW Segment 2 fa dP dt max Tau Weiss fe Tau Webs m Accepted Loops Event markers 1 ones Event markers 2 Before using all segments to estimate the ventricular volume we suggest verifying that 1 all segments provide a real volume measurement and 2 segment volumes are synchronized If these two requirements are not met the catheter might have to be moved and or the segment excluded from the ventricular volume calculation Baan s equation application Parallel volume removal Two methods exist to remove parallel volume from signal volume One for one segment catheters only One for one segment and multi segment catheters One segment volume catheter After computation the parallel volume is directly entered as an offset in the calibration window Zone 1 and 2 standard measures are modified by subtracting parallel volume from current standard measures Figure 2 ES Calibra Zenoni one prm Socio roda S Sena Ere ru iei anm 11 64 One or multi segments catheter The parallel volume cannot be applied as an offset in the calibration window for multi segments catheters An additional OPR10a module has to be inserted between the l
59. he following directory Destination Directoy C Program FileskHatacord To proceed wath the instalation in diferent directory click on the Browse bulton and The Installation wizard suggests an installation directory where all NOTOCORD hem installation files will be stored By default the recommended destination directory is C Program FilesWotocorda Click on Next Select your type of installation i NOTOCORD hem Evolution 4 2 0 232 Setup Usage situation vol Select in which case do you use NOTOCORD hem Evolution 4 2 0 232 The mast common application feature val be installed This option is Standard recommended for most users Additonal MOTOCORD hem Evolution 4 2 0 292 funetionallies vall be installed for GLP ermonment O GLP Environment Use this option bo choose which application features pou want installed and where they wil be installed Recommended for advanced users The above screen allows you to choose the type of installation Standard GLP Environment or Custom a Standard installation Context of use You are not working following the Good Laboratory Practices rules and you don t have the AccessManager license AMG50a token You are using only one or several of the following acquisition devices DataTranslation board DSI board or Video board Go to the chapter Standard installation b GLP Environment installation Context of use You are working following the Good Laborator
60. hen only contain the remaining graphs A Each graph in the configuration has Graph 1 hidden a box assaciated with it Modifying the height of a graph To modifythe height of a graph click one of the horizontal lines delimiting the graph selected and drag the mouse upwards or downwards The y axis scales for the graph selected and for adjacent graphs concerned bythe modification will be automatically expanded or compressed accordingly Reassigning an equal height to all graphs displayed i e not hidden Click on the tile button Changing the name of a graph Double click on title and type new title in the displayed properties dialog box Note You can also click the name box and drag it to any location in the display window or even delete the name Get Started Displaying signals Published on October 27 2011 27 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Using multiple display windows Instead of adding additional display graphs into the same window thus making it harder to read the various signals displayed itis sometimes more convenient to open a new display window and arrange the various windows as you like Hiding a display window Clicking the icon in the top right hand corner of a display window does not close the window but just hides it To restore the window select it from the Window menu in the Main window Hide Ctrl F4 Adjust Shift F3 Tile horizonta
61. icense number Send via Internet Copy to clipboard Uninstallation has been done An uninstall ID is generated This code must be sent to NOTOCORD in order to confirm that the uninstallation took place update your license allow you to reinstall it later Send the Uninstall ID viathe Send via Internet button if your computer is connected to the Internet byemail fax or telephone to your Sales Representative or NOTOCORD Customer Support after having copied the 2 IDs by clicking on Copy to clipboard Aconfirmation or error message appears to inform you about the outcome Case n 3 License Transfer When should you transfer your license Installation of the license on another computer Changing computer Transfer procedure Uninstall your license following the chapter Case n 2 License Uninstallation instructions Reinstall your license following the chapter Case n 1 License Installation instructions Case n 4 License Modification When should you modify your license Purchase of a new module Purchase of a new functionality Move to GLP Procedure Following the purchase of new module s or functionalities s you receive at the email address supplied to NOTOCORD in the license order a new lic file containing the electronic license and your new rights cf prerequisites Uninstall your license following the chapter Case n 2 License Uninstallation in
62. ilution 2 SV values in PVL10I module are displayed in the table at the bottom right corner after validation of the steady state zone Figure 5 E Miri i IN BRUN TT e t REI oni p adea gt i J a n nm n oe bd ior sz e 2 Hee eH A CE A EA Gum Se le For other measurement techniques SVis either computed directly or estimated by dividing the cardiac output by the heart rate on the same ventricular steady state zone Following Baan s equation the ratio 1 a must be computed and then applied using OPR10a Figure 6 Advanced Tutorials gt PV Loop Published on October 27 2011 Pes Ped dP dt max Tau Weiss r2 Tau Weiss Accepted Loops zones 50 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems oon Parallel volume OPRI083 bau Operation O E T imm Vin im EF WH OPR1084 Leal V Volume Accepted Loops Zones Event markers 2 This ratio can be computed directly using the following equation 1 a SV other SV PVL10I SVother is the stroke volume obtained using the other measurement technique SVPVL10I is the SV computed by PVL10I module Then 1 a must be inserted in the OPR10a module properties window as coefficient a Figure 7 Alpha properties Addition av br2 9 Multiplication a Y2 O Division fave v1 Output domain Output domain limitation Upper Limit 5000 Lower Limit 500 References
63. imilar shortcut in the Marks tab of the properties window Aname must be defined for each mark in the Calculated data tab ofthe properties window Aname must be defined for each calculated data in the Calculated data tab of the properties window The type of operation must be set for each data in the operation field of the Calculated data tab in the properties window Each data is defined using two marks and both marks must be Published on October 27 2011 52 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Mark x field of y output is empty EEG10a Message Maximum frequency must be greater than minimum frequency for Band Name band SubBand Name subband frequency must be defined within the frequency range of Band Name band License Management Message License installation from floppy disk is not compatible with the existing license on your computer License installation from file is not compatible with the existing license on your computer Uninstallation failed Please contact Notocord support Invalid activation key Please enter it again An activation key could not be generated for this license Please contact Notocord support An error has occurred during the connection to Notocord server Please try again later The uninstall information could not be sent to your Notocord Sales Representative Please contact Notocord support and send the uninstall information The same li
64. in memory then click the Zoom command button and select the region of the graph to be enlarged Release the mouse to apply the zoom command if you chose the 2xzoom command just click the graph to be enlarged Horizontal and vertical displacement To move the display portion along the xaxis click the x axis and drag the mouse sideways Release the mouse to display a new portion of the graph You can also use the and keys to displace the graph in regular increments The vertical displacement procedure is exactly the same Click the y axis and drag the cursor or use the 1 and keys Additional display options Coordinates of a point or portion of a curve Click any point on a graph to displayits coordinates If coordinates are not displayed immediately tt slightly drag mouse while pressing the left button To displaythe coordinates for a region select the region using the mouse Displaying an entire test Button Shortcut Actions Illustration Xaxis scaling button 14h L en Ma Q a hh Click the X axis scaling button to display all signals throughout the ml l duration of the test including periods during which acquisition was T sc a EE stopped k Ctrl X Note You can use this command at the start of the acquisition process to immediately obtain an enlarged view Scrolling mode selection During acquisition NOTOCORD hem allows you to view signals in three scrolling modes Window scrolling Replacement
65. ion Published on October 27 2011 13 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems i NOTOCORD hem Evolution 4 2 0 232 Setup Data Manager Account Select data manager account Select the Windows account that vall hase access bo the warkhle directany Windows Account Accom Passwo0d Conhimation In parallel an NTFS secunty strabegy has bo be applied to the worklile directory to control access irom othe accounts f no account e entered access lo the worklile directory vill be allowed to al accounts To select the Windows account which will be used to administer NOTOCORD hem data click on the Browse button Select just one account in the standard Windows dialogue box to select the user Once selected this account appears in grey in the Account field Type the password corresponding to this account in the Password field and re type it in the Confirmatior field Click on Next Install the software features i NOTOCORD hem Evolution 4 2 0 237 Setup Select Features wu i Be de Please select which l esbures you woud like bo install e HOTOCORD hem ll Faatura ratita AMG SOs BLA Main program Cowl Oa Select the feature s you want to install from the following list in accordance with your NOTOCORD license AMG50a Activates GLP and 21 CFR Part 11 mode of NOTOCORD hem BUX10a Buxco MAX II MAX 1500 Acquisition server CSW10a b Corscience
66. isplay module used to view signals in a continuous manner The Continuous display window can contain one or more graphs Each graph can show one or more signals Get Started Configuring acquisition Published on October 27 2011 22 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems CID 6041 CYC10a Processing module used to determine the cycle of a generally repetitive signal and calculate its characteristic points maximum minimum highest slope KBD30a Tools module used to set markers indicating key moments during a test for example the injection of a given product at a given time Note The various modules available in the Configuration window are normally sorted by S xe A tabs You can also display the modules without sorting them To do this right click the modules toolbar and deselect Arrange modules in tabs Setting up a module Aconfiguration is created by setting up the various modules required and connecting them together in the Configuration window for some modules certain parameters must also be specified To setup a module proceed as follows Sr qn rs lis apes a impe a Click the corresponding module type NSR10a acquisition module in this example Esa zm T t8 tH Was ae qoa berare de he ET n Point and click where you wish to set up the module Notes To position a module in the Configuration window click the module and drag it to the required location
67. ithm browses through the file and retains the most representative morphologies Each reference beat is manually marked by the user step 2 These user defined marks are then applied over all the beats identified on the QRS input step 3 The positions of the applied marks are determined by comparing the morphology of a given beat to the previous and to the next reference beats see Figure 1 Previous Next reference beat Current beat reference beat ul ECG51a1 Propagation of marks Propagation of marks d i e __ _ __ Triggering ECG51a with a QRS detector ECG51a requires triggering by another module QRS10a for instance which performs beat detection Detected beat triggers must be located on the QRS complexes and connected to the QRS input of ECG51a An analysis window around each QRS trigger is set to define the zone considered for the analysis of each beat QRS triggers are also used to align multiple beats in the different 3D views offered by ECG51a Figure 2 a i Besh ii Ap SAG AR pF For more detailed information on ECG51a capabilities please refer to the ECG51a reference document Overview of ECG51a display window Figure 3 gives an overview of ECG51a display window after signal analysis Advanced Tutorials Calibration Published on October 27 2011 38 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Synchronized continous display chart zum A A
68. l data Highly compressed data e g 400 Mo for a typical 24h telemetry study with 6 dogs High capacity storage 100GB file with fast access to any period of the signal Possibilityto schedule acquisition time periods Advanced time synchronization between different data acquisition systems eg DSI implants amp video cameras without specific hardware links Data analysis amp review Online and offline analysis Possible data review during acquisition without inducing interruptions Post acquisition file reviewable instantly No time consuming replay needed for recorded signals review Opening of large data files in a few seconds Extensive library of analysis modules and signal processors Possible implementation of external modules onto NOTOCORD hem software platform Processing and analysis of NOCOTORD hem and Matlab data streams in both environments using unique library of functions Display Online display Raw data and calculated trends easily accessible for display Graphical superposition for data curves and tendencies comparison Advanced display capabilities with continuous waveforms trends and numbers Channels overlay within same display for flexible visualization of waveforms No limitations in the number of displays and up to 20 individual graphs on each display Report Exclusive reporting system based on Mcrosoft Excel Direct data transfer from file to final report Excel template creation for time saving reporting T
69. l settings are disabled This channel is being recorded with different settings Click here to apply recording settings The number of channels exceeds the license permission only for VSH10a The OK button is disabled Cause User does not have sufficient permission on the destination folder or there is not enough disk space available Appears when saving the current analysis zone as a control one xyd User does not have sufficient permission on the source folder Appears when loading a control file xyd in the nss file Published on October 27 2011 55 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Shortcuts in NOTOCORD hem List of shortcuts 1 Main window Table of Contents 2 Configuration Setup window 3 CID60a v 4 ECG51a 6 VIME10e v Main window Shortcut Action Ctrl Space bar Ctrl A Ctrl R At F At E At A At T At W Alt H Ctrl N Ctrl 0 Ctrl P Esc Alt F4 Switches from Main window to Configuration Setup window and vice versa Starts Stops acquisition Recalculates Opens File menu Opens Edit menu Opens Acquisition menu Opens Tools menu Opens Windows menu Opens Help menu Creates new file Opens file browser Prints Closes window e g Properties window Recalculate window etc Closes NOTOCORD hem Configuration Setup window Shortcut Action Del CTD60a v Deletes selected module s Shortcut Action
70. le with an invalid license not expired Selecting a token file with an expired license Error management messages are generated in Matlab in order to alert the user of unexpected conditions detected when running a function The syntax of the messages is compliant with standard Matlab error messages syntaxfor functions Message MP110a license not found GLP file modification not allowed filename file not found Unable to open file filename No Modulename streamname stream in filename file Stream type not accepted NOTOCORD hem stream overwriting not allowed Stream type change not allowed Invalid number of input arguments Invalid number of output arguments Invalid input parameter Internal error PVL10I Message Please check that pressure and volume input signals are properly connected Analysis zone Xis not included in a single acquisition period Pressure and Volume input signals are not sampled at the same rate in zone X Appendix gt Error index Cause MPI10a token is not present or activated Attempt to write in a GLP file The specified NOTOCORD hem filename does not exist Ns GetDatalnfo NsGetData source filename does not exist NsSetData destination filename is open and needs to be close in order to write data in it The name of the specified data stream is not correct The stream type specified in input is not supported Itis not possible to add or overwrite data streams be
71. lly Shift F4 Tile vertically Shift F5 Cascade Windows w Toolbar w Status Bar CID60a1 Display window configuration You can specify the style crosses points vertical lines etc color and thickness for each curve in a display window Button Action dis A a lu To configure a display window click the top left button in its toolbar The Display D Wh configuration dialog box appears TEEM a The left part of this dialog boxlists all available data S SAI Hl The right part lists the data connected to the display module inputs the tree ES me structure showing the names of graphs and display modules is initially closed K Illustration To change the display of a data select itin the right part of the dialog box a small red ball appears and choose the style color and thickness required a 0 C L G1 iD NSA10a1 Simulation 1 B 2 NSRITUAT Simulation_2 M la X soon Ll mA EH lt NOAA P S CEA AA EES Hal BSCOBSSEO Beoooesrc BEEBE EE ES BEEBE EEE nm Autres couleur Get Started Displaying signals Published on October 27 2011 28 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Note The left part of the dialog box lists all data for the current configuration including data corresponding to display modules which have been deleted We recommend that you experiment with different tyoes of configurations so as to become familiar with the various possibilities Get
72. lly in order to choose the appropriate computer configuration e Data types video or physiological signals Signals properties shape amplitude which can affect the calculation time of some modules e g those requiring form identification such as ECG analyzers Total sampling rate of all outputs from modules present in the software configuration window Number of display modules graphs displayed curves Number and complexity of analysis modules calculations and output connection status Number of signal processing modules connected to active outputs Afirst step for choosing a configuration would be to add up sampling rates for each acquisition or calculated channel Some examples are given in Table 1 below Description PC configuration Acquisition of 8 x 1 kHz channel 8 digital filters 8k 8k 16kHz Entry Acquisition of 2 x 50 kHz channels 1 low pass filter on 1 channel 100k 50k 150kHz Standard Acquisition of 8 x 1000Hz ECG channels 8 ECG related analysis modules Standard Acquisition of 32 x 1000 Hz channels Standard Acquisition of 8 video channels Advanced Reviewing of video data with any other signals Standard Table 1 Examples of experimental setups and corresponding recommended PC configurations PC configurations We recommend that the user carries out performance test under conditions similar to those of the experiments Characteristics Entry Standard Advanced Comments Entry level Entry level Computer
73. longing to NOTOCORD hem native modules Stream type cannot be modified Not enough or too many input arguments Not enough or too many output arguments One of the input arguments does not have the correct type A message identifying the cause follows Not related to any of the above or to any Matlab errors An entry in the Notocord log file is generated Cause One of the mandatory inputs is not connected Zone Xis not entirely included in a single acquisition period Pressure and volume signals do not have the same sampling rate on Zone X Published on October 27 2011 53 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Analysis zone X must include a full cycle You may recalculate the module and then check that the analysis zones are properly defined Overlapping of analysis zones is not allowed Analysis zone Xmust not contain more than Ysamples Sampling rate must be within 500 Hzto 10 kHz The zone defined for parallel conductance volume computation must include at least two complete cycles You may recalculate the module and then check that the zone is properly defined and validated Error writing file X Check your rights on this folder and available disk space Error reading file X Check your rights on this file PVL10s Message Please check that pressure and volume input signals are properly connected Analysis zone Xis not included in a single acquisition period Pr
74. ls use itis advised to qui all Windows applications belor running the wizard Ta close the instalation wizard click on Cancel To continue wath the metallaton clock an Hest Warning This sofbusre is protected be the law on copynght and intematonal treaties NOTOCORD Check that the displayed version number 4 x x xxx is the right version and click on Next Exit installation The cancellation button found on each installation program screen allows you to interrupt the installation process at anytime during installation without any modification being made on your system Click on Cancel calls up the confirmation request box shown on Figure below ig NOTOCORD hem Evolution 4 2 0 232 Setup Installation is nat complete Ifyou quit the setup program now the application will not be installed rau can run Ehe setup program at a later time to complete the installation To continue installing click Resume To quit the setup program click Exit Setup Click on Exit Setup to interrupt the installation process or click on Resume to continue the installation Carry on with installation Setup gt Software Installation Published on October 27 2011 9 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems i NOTOCORD hem Evolution 4 2 0 237 Setup General Terms and Conditions All users of the Solbvare ans required to agree bo the folowing General Tems and Conditions az a condition bo la
75. ne is invalidated VSH10a b Message No VSH card detected Check license and hardware setup This channel is being recorded with different settings Click here to apply recording settings VSH08a card and VSH10b license are required for this configuration XYD30a Message Writing to file F failed Check your rights and available disk space on this folder Reading file F failed Check your rights on this file Next module Appendix gt Error index current NOTOCORD hem session is different from the configuration of the same channel currently in acquisition in another NOTOCORD hem session Cause The number of the marker does not exist The Event Marker signal is not connected in input Reference time or position of marker and Offset are outside or not in the same acquisition period The zone must belong to the same acquisition period Reference time or position of marker Offset and computed end time are outside or not in the same acquisition period The zone must belong to the same acquisition period The number of R peaks between the boundaries of the zone is not greater than the number of beats requested 2 The duration of the requested zone is 0 or the start time is equal to end time No signal is connected to the first input of the module or no acquisition has yet been made The position or duration of a validated zone has been modified Cause No video card or appropriate license is detected A
76. nstalled on the computer If it is not the installation program will automatically offer you to do so Microsoft Office Excel 2003 or 2007 should be installed on the computer For an update any previous NOTOCORD hem version installed on this computer must be uninstalled from Control panel gt Add or Remove Programs menu If your license was prevously installed you don t need to uninstall itto perform NOTOCORD hem software installation For an installation in a GLP environment in order to limit access to files produced by NOTOCORD hem e Aspecific Windows user account has to be assigned to secure NOTOCORD hem data access The associated password should be known by the person undertaking the installation Specific NTFS rights have to be applied to the workfile directory to allow NOTOCORD hem to work with this directory Start the installation Open a Windows session using an account with all the administrative rights for the computer Insert the NOTOCORD hem CD ROMinto the CD drive If the installation program does not start automatically start the Setup exe program from the root directory on the NOTOCORD hem CD ROM The installation wizard starts with the screen below i NOTOCORD hem Evolution 4 2 0 2372 Setup Welcome to NOTOCORD hem Evolution 4 2 0 232 installation wizard Thanks for choosing NOTOCORD hem Evolution 4 2 0 232 The weard wil install NOTOCORD hem Evolution 4 2 1 232 and all the necessary components hor i
77. nual Printed on 28 Oct 11 NOTOCORD Systems 3 Lar 15 a age Os 4000 8000 s mim 16000 12000 s Check if this instability comes from an incorrect reference beat marking Right click on the area of interest Select Showleft reference beat or Showright reference beat Identification numbers of the left and right reference beats are indicated in brackets Check reference beats marking on the 2D Editor chart e DAA c T Display 1 1 e tor Panis Time Offset 154102079 ud fu ae ORS Stan ad H T End QRS wu 3150 i Show beat 4410 5053583 asar Show left reference best 4 A a 2450 Auto scale Display Apply ba all b i insert graph 1750 Delete graph iig f Send to clipboard is PM ms PLC M er Nt Display configuration 5 4284 me 7 269 me uen ns bom 160 ms ms Os B ms 1850 ms 240 ms In the example above Figure 33 QRS duration interval instability is explained by QRS End incorrect manual marking on reference beat 7 Mowe the QRS End mark to the correct position towards the right end side Run the signal analysis again See the results on Figure 34 100 Beat 4k E Qr gt ou oS Time Olfeet 1h 0207S F Stat GAS Stat 350 R Peak T End 3150 2450 1750 n f mae j y ae y pA T Jj tuu teur T IA ur B ra rtm 1050 200 me 100me Ds 100 ma 00 m 300 mi Advanced
78. o the previous or next reference beat Signal analysis When marking is finished Applyitto the rest of the signal with the Analyze signal button Figure 13 Once the signal analysis process is complete Marks are visible in the upper display chart The Global statistics panel on the bottom right corner Figure 3 indicates the coverage percentage Figure 14 For each mark the coverage is calculated as number of marks number of input QRS triggers over the whole signal The non synchronized continuous display chart above the Global Statistics panel shows an overview of PR QT QRS intervals and Heart Rate Coverage P Stait 87 33 QRS Start 39 73 R Peak 99 73 ORS End 99 74 T End 95 19 This chart is useful to observe potential drug effects and monitor data quality Indeed if you notice any interval instability in a particular area on this chart right click on it to see the identification numbers of the corresponding reference beats and access them to check the marks See an example of interval instability at the end of this guide in the chapter Improve your analysis Views The 2D 3D chart of ECG51a offers 4 visualization modes 2D Editor Waterfall Topography and 3D View Except for the 2D Editor each view shows multiple beats aligned on their QRS trigger Advanced Tutorials gt Calibration Published on October 27 2011 41 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems
79. of earlier zones New QRS output is displayed green and can be used to trigger ECG51a Tips Several zones can be calculated successively with an automated module such as QRS10a See example on Figure 29 When recalculating a new zone two cases mayarise If the recalculation zone overlaps an existing calculation zone then previous data are deleted and replaced lf calculation zones do not overlap then the existing data located before the new zone are saved while the existing data located after the new zone are deleted Advanced Tutorials gt Calibration Published on October 27 2011 44 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems gt If you need to run the analysis from the Baseline marker you can recalculate the QRS10a module from the time of the Baseline marker For instance on Figure 30 QRS10a recalculation starts 2700 seconds after the beginning of file QRS1 GRS Abnormal detections Acquisition ECG Recalculate from 2700 to 290204 Add remove a reference beat Add a reference beat When do you add a reference beat When you notice thata zone of interest was not analyzed or not correctly analyzed Warning Adding a reference beat may increase coverage locally but may decrease coverage in other areas in which the previous set of reference beats was more appropriate Therefore adding a reference beat is not recommended for improving global coverage
80. on E DEMONSTRATION LICENSE FOR MOTOCORD HEN EVOLUTION TEST ONLY NG PRODL BEA TEN HOTDCORO hen Eseolubon pour ecquitition eniepiienses el sedens de cignasus el ar Aia scirem la mode GLP at Fi CFFE Pat 13 de HO TODO PD hem E ara Aval de polen facie cai desque dean parara PT E DEG la Vies impulsora pestes E TP Fia par napason rara El 3cPtn Afhches de h scope amp retraces Emm Lice Te The TokenManager window contains 2 parts he upper grid shows the license to be installed and its contents The lower grid shows the list of licenses and their contents installed on your computer Tick the box corresponding to the license you wish to install on this computer Alicense must be installed entirely The installation of a single module of the license is forbidden Click on Install p Z3 Install In order to install your license you must enter an activation key that can be obtained elhet new using the Internet or later by copymg pasting the information in an emal to your Sales Representative Hardware ID Install 1D Get key via Intemet f Copy to clipboard Please enter your actrvabon key below e There are 2 cases The end user computer is connected to the Internet Click on Get key via Internet An information or error message appears with the action outcome If the action succeeds you receive your activation key directly by email The end user computer is not connected to th
81. on requires a Buxco device not The serial number of the device in the detected on this computer Click here to change loaded configuration does not match the the configuration number of the device currently connected ECG31p n the presence of a QRS Detection Error marker the RR interval duration between the two valid QRS complexes before and after the marker will not be computed In addition no P Start and T End points will be positioned between the second R peaks preceding and following the QRS Detection Error marker n the presence of an Abnormal Beat marker the RR interval duration between the current and the preceding R Peak points will not be computed In addition no P Start and T End points will be positioned the second R peaks preceding and following the QRS Detection Error marker n the presence of a T P Overlap marker on the current R Peak no P Start and T End points will be positioned between this R Peak and the preceding The Buxco device is already used by another acquisition server with different sampling frequencies Cause Observations All settings are disabled The OK button applies the sampling rates of the server already in acquisition to the selected acquisition server The OK button opens the properties window one The QT interval of the preceding beat and PR interval of the current beat will not computed ECG51a Message Changes are being made They will become effective after the
82. ons security In a GLP environment usage can be restricted to only an authorized user or group Can trouble access to files during data processing acquisition or recalculation m Type of Manufacturer Model Description terrace DT301 DataTranslation 16 analog channels 12 bits 150 kHz max PCI DT302 DataTranslation DT3010 32 analog channels 12 bits 1 25 MHz max PCI DataTranslation DT980x 16 channels 12 to 16 bits 100 kHz 500V isolation between PC and device USB 1 1 Digital Interface from DSI s telemetry hardware to NOTOCORD hem software DataSciences EE Note PCI Express interface card designed since summer 2008 is highly a d International se 3 44 recommended by DSI Legacy PCI card may have some trouble with recent nd PISO motherboard OHAUS AR5120 OHAUS balance server RS232 VSH10a b DS 40xx 4 8 Mdeo channels PCI Instrunet 1200 Instrunet acquisition server PCI TMS PORTI 7 Up to 40 channels 22 bits 2000 Hz sampling rate USB REFA8 CorSciences BT3 6 Up to 3 leads 500 Hz per channel 18 bits 500 Hz sampling rate DC coupling Bluetooth Appendix Graphic controller Table 3 Supported hardware Graphic Controllers integrated in the CPU Chipset MUST NOT BE USED as 815E 845GL 865G 915G 915GV 910GL 945G etc http download intel com products graphics intel graphics qguide paf Estimated data file size Files size is mainly determined bythe number of continuous signal channels red outputs and their sampling
83. ord Edit To quickly draw a graph that represents the extracted data Custom Toolbars Excel gt Notocord Chart To ensure extracted data match appropriate events eg extracted data really correspond to a fully detected heartbeat This Time matched extraction wizard is only available with an activation key Custom Toobar Excel Hotocord Tne meiched Extraction wizard Extracting file data A 6 MN From the Excel spreadsheet select the cell where you wish to place information on the data 1 2 fles 3 El a ap eie Custom Toolbar Excel lt gt Notocord File info wizard Click on the File information wizard Get Started Analyzing with Microsoft Excel Published on October 27 2011 34 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems File Info Wizard The window that is displayed lets you select the file to analyze along with the information that you wish to place in the cell Select the file that you wish to analyze using the Browse button Select the information that you wish to place in the cell and validate it The cell contains the selected information tate perimen nes Note When you select a cell containing data generated by one of the wizard the formula bar displays exactly how the data was extracted into Excel Ns File A Data ExpenmentO nss As a general rule each cell or group of cells that contains information generated by one of the thre
84. r than the current one 4 Opening a data file 5 Creating a new data file 6 Saving the current configuration as a Merro Saving the current configuration Once the configuration has been generated it can be saved under a user specified explicit name so that it can be reused by other applications Note A configuration mainly includes The configuration diagram module layout and parameter settings links between modules The display layout size and parameter settings type of signals color line thickness The size and layout of the Main window and the Configuration Setup window To save the current configuration click on the Save configuration button in the configuration screen or on the item with this name in the File menu and specifythe name of the configuration file and where to save it EJ eese pok cmd Hew CHi N Open Cie SOS i sane is 234 E ps Save configuration Pty Load configuration Di amp i a Dii DOCi RV Illa Configuration Raport Ext AFA Saving the data file under another name You can save your data files under a different name than the one assigned when they were opened or created New Ctri M Open Cirio Close To do this use the File Save as command from the main screen and specifythe name of the Baa sl m vin r data file and where to save it Save configuration Configuration Report Exit A F4 Loading a configuration other than the current on
85. raceability of exracted data NOTOCORD hem structure amp Operating mode Components The kernel KRN is the heart of the system It contains all the functions used to control data acquisition processing analysis and display It comes with 4 default modules o NSR10ais an acquisition module that allows the simulation of a previously performed acquisition o CTD60a is a continuous display module used to visualize signals o CYC10ais a processing module provided to determine the cycle of a repetitive signal and calculate its characteristic points o KBD30a is used to insert markers on key moments during a test The acquisition servers ensure compatibility between NOTOCORD hem and acquisition hardware With more than 120 modules to choose from for acquisition signal processing analysis display and other signal treatment you can build your User Manual NOTO CORD hem detailed features Published on October 27 2011 3 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems personalized analysis The Excel Wizard provides fast and efficient data extraction into Microsoft Excel The highly secure and compliant applications Access Manager Lab Manager audit trail user access management etc allow you to be compliant with Good Laboratory Practice requirements and 21 CFR Part 11 e Data storage access system is managed by an independent system named FOG Data files are identified bythe nss file extension Ds N
86. rd field and re type itin the Confirmation field Click on Next Setup Software Installation Published on October 27 2011 12 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems ie NOTOCORD hem Evolution 4 2 0 232 Setup Acquisition Server Select acquinhan sever Acquetion Servers 4 VSH Dab 4 B channels video acquisition server DTSB a b D ataTranslation cand 16 32 analog channels acquisition server e D SIB a bv c d DSI OpenAAT 4 8 12 16 sources acquisition server Select the acquisition server s you have in your license byticking the relevant box and then click on Install Installation is undertaken automatically and a progress bar informs you on how operations are progressing Click on Finish to close the window To complete the final stage by installing the license go straight to the next part License installation Custom installation i NOTOCORD hem Evolution 4 2 0 237 setup Usage situation Jc Select in which case do you use MOTOCORD hem Evolution 4 2 0 232 The mast common appkcation features val be installed This option is recommended for most urart Additonal NOTOCURD hem Evolution 4 2 0 232 functionalties vall be GLP Environmeri installed for GLP envmuorment S Use this option to choose which application features pou want installed Custom and where thes wil be installed Recommended for advanced users Select Custom
87. rsonal directory The default directory used by NOTOCORD hem corresponds to a sub directory called Notocord in the My documents directory of the user who opens the Windows session You can type the name of the sub directory of your choice in the Sub directory box Once the workfile directory has been selected click on Next ie NOTOCORD hem Evolution 4 2 0 237 Setup Acquisition Server Select acquinhon server Acquetion Servers 4 VSH Uab 4 B channels video acquisition server DTSB a b DataTranslation cand 16 32 analog channels acquisition server e D SI amp a bv c d DSI OpenAAT 4 8 12 16 sources acquisition server Select the acquisition server s you have in your license byticking the relevant box and then click on Install Installation is automatically undertaken and a progress bar informs you on how operations are progressing Click on Finish to close the window To complete the final stage by installing the license go straight to the next part License installation GLP Environment installation i NOTOCORD hem Evolution 4 2 0 232 Setup Usage situation Select in which case do you use MOTOCORD hem Evolution 4 2 0 232 The mast common application features val be installed This option is recommended for most urart Additional MOTOCURD hem Evolution 4 2 0 232 funcetionallies vall be mstalled for GLP ermironment Use this option to choose which application features pou want installed and
88. scrolling and Continuous scrolling Button Actions A Scroll button Illustration Select the scrolling mode required and click the Scroll button the mode selected is stored in memory Scrolling mode Description ie When the curves displayed reach the end of the display window a new signal image is displayed Replacement Instead of being displayed in a new window the new signal image replaces the previous one The scrolling current point is indicated by a vertical line moving from left to right Continuous scrolling Displaying a graph full screen Get Started gt Displaying signals The signal image scrolls continuously new values are displayed at the right end of the window Published on October 27 2011 To select the scrolling mode right click the Scroll button UO Au EA Illustration 2 E el 26 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Button Shortcut Actions Illustration Full screen graph button A i y i i A M Select a graph and click the aur Full screen graph button to displaythe graph full screen AU Click this button again to redisplay all of the graphs or Ctrl F Hiding a graph The graphs shown in a display window are identified by numbered boxes under the toolbar in the right hand section of the window To hide a graph click the box with the corresponding number the box will then look closed The display window will t
89. structions Reinstall your new license following the chapter Case n 1 License Installation instructions Diskette license Take the yellow floppy disk containing your license If you are installing NOTOCORD hem software and the floppy disk is already inserted in the floppy drive then the TokenManager application will open automatically Otherwise insert your yellow floppy disk into the floppy drive Then launch TokenWVanager program accessible via the menu Start gt Al Programs gt NOTOCORD hem Evolution gt TokenManager 9 HOTOLCORD Tokendanage Digital espias HOTOCOFO han Esplendor acqueation mosidrg and anale of apak aeo date Weti Life s hl apurar ug tod deve L Grat india ere Petro naxgrapisg brakis Earle cariche Peningi inns neo pa phon ndo Datel ogee cand Gain channel squiahon persa Cera parade Gertie adopt iras gi intel pero iore fin E rect icara kore floppy ceri Cr raa crc The window of TokenManager consists of 2 parts The upper grid shows the list of licenses to be installed and their contents The lower grid shows the list of licenses and their contents already installed on your computer Click on the Refresh button to post your floppy disk licenses in the upper grid Setup License Installation Published on October 27 2011 19 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems What do you want to do Case n 1 License Installation Case n 2 Li
90. tinuous display of two ECG and ABP default signals provided by the NSR10a module We recommand that you set up the same configuration ECG Signal are ABP Signal Starting the acquisition process There are several ways to start the acquisition process The typical wayis to click the START button in the Main window Note Important In the main window s toolbar the NOTOCORD logo in the upper right hand corner shows a sine wave when acquisition is in progress In addition the various module outputs will flash at regular intervals and the traffic light icon on each module will light up normally green to indicate that acquisition is in progress You can also start the acquisition process in one of the following manners From the Acquisition menu select Start e Ctrl Ashortcut Zoom and scaling options Once the acquisition has started the signals displayed are not always immediately readable as shown in the example below curves overly compressed or exceeding the default y axis scale CTD60a1 J JOT LETT IET t So 8 amp 1 00 g 50 20 0 Important During acquisition mouse manipulations on time scale i e dragging expansion or compression will stop signal scrolling To resume scrolling click the Scroll button or use the corresponding keyboard shortcut Ctrl S NOTOCORD hem provides several zoom and scaling options Horizontal zoom Shortcut Action Illustration Get
91. u want to do Case n 1 License Installation Case n 2 License Uninstallation Case n 3 License Transfer Case n 4 License Modification For further information please refer to the Licensing reference document Prerequisites 1 You must have access to the e mailboxto which will be sent the lic license file containing your rights and the modules the activation key the confirmation messages This e mail address is the one given bythe customer to the NOTOCORD Sales Representative in the license order 2 You must beforehand have uninstalled any diskette license present on this workstation Indeed electronic and diskette licenses cannot be installed on the same computer Case n 1 License Installation Save the lic license file you received by e mail in a folder on the end user workstation Launch the TokenManager program accessible via the menu Start gt All Programs gt NOTOCORD hem Evolution gt TokenManager 4 HOTOCOAD Token anager E inal icerum ore le Cni cr rm kom lips cin 2 brad cerco Click on Install license from file Then click on Browse and select the lic file File name NOTOCORD_8768 001278 lic Files af type Hotocord Token Files Setup gt License Installation Published on October 27 2011 16 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems 29 HOTOCORD Tokendanaper Available knees __ Check the boerae to rob on computer and click on nitas butt
92. utomatically building graphs You can quickly obtain a graph that illustrates the data calculated by the Formula wizard First select the values zone that you wish to display then click on the Graph button Get Started Analyzing with Microsoft Excel Published on October 27 2011 35 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems You can then perform all of the actions supported by Excel on the graph The NE ile 1 Ji Is it m BLUE A numbers of the points Note Once the graph has been generated any change to the data configuration will impact the graph Displaying the analysis zone You can display the analysis zone of a cell or column with the Edit wizard This allows you to perform a visual inspection of the data It also allows you to change the starting point and duration of your analysis zone Click on a cell where the contents are calculated by a wizard In the example below the cell displays the maximum value of the signal The analysis zone created bythe formula wizard starts 60 seconds after the beginning of the file and has a 20 second duration Then click on the Formula editor button apo The zone corresponds to the one configured using the Formula wizard 1 minute after the start of file duration 20 seconds You can then move the zone and or change its width When you validate it the cell is automatically recalculated according to the new parameters For cons
93. wful use Each order of Saftware or Products is subject bo and Licenses is deemed to have accepted these General Terme and Conditions unless otherwise agreed in writing by Notocord NOTOCORD 1 DELIVERY The delivery schedule For the Software is only estimated Actual delivery can occur on time early or labe without penalty and without being considered a breach of these terms and conditions The shipped goods including Products MOTOCORD software and material are st the Licensee s own risk and charge Licensee shall be responsible for verifying the completeness and accuracy of the goods at the arrival 2 PAYMENT The Full payment is due 30 days after delivery IF payment of the price or any part thereof is not made by due date NOTOCORD shal be entitled to charge interest on the outstanding amount at the rate of 1 5 per full or v accept the General Terms and Conditions Remind me later Accept the general terms and conditions and click on Next If you choose the Remind me later option this window will appear again after 48 hours when opening NOTOCORD hem The user is required to agree to the General Terms and Conditions to be able to use the software Choose the destination directory i NOTOCORD hem Evolution 4 2 0 237 Setup Destination Directory NO Selecta dreckory wher NOTOCORO hem Evaluban 4 2 0 232 wall be installed The Installation Wizard wil install the files for NOTOCORO hem Evolution 4 2 0 232 in t
94. y Practices rules and you have the Access Manager license AMG50a token You are using only one or several of the following acquisition devices DataTranslation board DSI board or Video board Go to the chapter GLP Environment installation c Custom installation Setup gt Software Installation Published on October 27 2011 10 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Context of use other cases than the ones listed in a and b Go to the chapter Custom installation Choose your type of installation click on Next and go to the corresponding chapter Standard installation i NOTOCORD hem Evolution 4 2 0 232 setup Workiile Directory i Selecta workhle drechon where data wll be stored Files created by NOTOCORD hem Evolution 3 2 0 2 32 will be ventber in Uis directory Whorkhle Direction Shared by al users C Program FilezMotocondL ata My Documents custom directory for each user Sub directone IN ctocond The standard installation starts with selection of the default directory where the data file produced by NOTOCORD hem will be written Choose one shared directory for all users to allow the files produced by NOTOCORD hem to be easily shared regardless of which user opens the Windows session The workfile directory proposed by default is C Program Files Notocord Data e Choose individual user directories so that each user can save his her data in his her pe
95. yed in the bubble Store Memo conhigurstion displayed for the Memo button Get Started gt Managing files Published on October 27 2011 33 60 My NOTOCORD User Manual Printed on 28 Oct 11 NOTOCORD Systems Analyzing with Microsoft Excel Table of Contents 1 Extracting file data 2 Hacing data in the spreadsheet 3 Automatically building graphs 4 Displaying the analysis zone Notes This section assumes that you are familiar with the use of Microsoft Excel It briefly describes the analysis features provided by Microsoft Excel These features are described in detail in the chapter on data analysis During the NOTOCORD hem installation a function is added to the system createing a link between Mcrosoft Excel and NOTOCORD hem Upon opening Mcrosoft Excel you will find five buttons added to your Mcrosoft Excel toolbar These buttons or wizards help for data extraction and analysis Code uw ha L To extract various information from a data file filename acquisition duration acquisition start time etc To extract experiment information values average number of points maximum etc Custom Toolbars Excel Motocord Formula wizard To extract information on markers number type assigned keys name etc Custom Toolbars Excel lt gt Notocord Event Markers wizard To visually redefine the data analysis field Custom Toolbars Excel Notoc

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