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BioShake user manual

1. 1 BioShake iQ 2 Power supply 3 Power cord Operating manual no picture Fig 3 2 BioShake XP 1 with power supply 2 and power cord 3 8 Issue 06 2013 User manual BioShake series Installation 4 Installation Unpack and carefully check the instrument Report any damage or missing items to your local distributor If no damage is found place the device up on a stable horizontal surface Power supply On Off DC 24 V Fig 4 1 Connections at the rear side of device BioShake iQ and BioShake XP Before starting to work with the BioShake Remove the cover plate before installing an adapter plate Loose the 3 torx screws with the torx screwer at the adapter packaging and remove the cover plate If the adapter will not be removed before installing an adapter the adapter will not be recognized by the device Place an adapter on the shaker chapter 5 Changing of adapter plates Plug the external power supply 2 into the 24 V socket at the rear side of the BioShake iQ or BioShake XP Plug the power cable 3 into the power supply 2 and into the wall socket Turn On the instrument It is advisable to carry out a test run at maximum speed to ensure that the device does not move while mixing User manual BioShake series Issue 06 2013 9 Changing of adapter plates Changing of adapter plates To change the adapter plates please follow the subsequent steps Attention If the security cover plate or
2. 3 000 1 800 m NO e oO 3 000 BE Available adapters 848 1808 1061 848 1808 1062 848 1808 1063 848 1808 1065 848 1808 1066 848 1808 1067 848 1808 1071 848 1808 1072 848 1808 1121 848 1808 1131 848 1808 1041 848 1808 1064 848 1808 1021 848 1808 1031 848 1808 1093 848 1808 1094 Description A Without adapter heating function not available B All non classified adapters heating function not available Adapter for 24x 2 0 ml or 15x 0 5 ml tubes Adapter for 24x 1 5 ml or 15x 0 5 ml tubes Adapter for 40x 0 5 ml or 28x 0 2 ml tubes Adapter for 35x 2 0 ml or 24x 0 5 ml tubes Adapter for 35x 1 5 ml or 24x 0 5 tubes Adapter for 35x Lysis tubes 0 5 2 0 ml Adapter for 30x 2 0 ml glass vials Adapter for 20x 4 0 ml glass vials Deep well plate adapter 96 well 1 000 ul Eppendorf Deep well plate adapter 96 well 500 ul Eppendorf Microplate adapter 96 well standard PCR plate universal Adapter for 96x 0 2 ml tubes Microplate adapter flat bottom Microplate adapter universal 96 well round bottom Adapter Falcon tubes 4 x 50 ml or 2 x 15 ml Adapter Falcon tubes 12 x 15 ml Not available at the time 848 1808 1022 848 1808 1051 Customer specified Microplate adapter flat bottom high base Microplate adapter 384 well standard PCR plates Mixing speed classification of adapters Issue 06 2013 User manual BioShake series Operation All pending informa
3. 35x1 5 ml and 24x0 5 ml 35xlysis Tubes 0 5 2 0 ml Adapters for glass vials Customized Adapters OLEI UO 30x2 0ml 20x40ml For individual reaction vessels Fig 9 1 BioShake adapters User manual BioShake series Issue 06 2013 23 Maintenance and repair 10 Maintenance and repair 10 4 Cleaning and maintenance The device is maintenance free Before cleaning the BioShake disconnect the power cord and make sure that the temperature at the contact surface is below 40 C If contaminated the device may be cleaned using a mild soap solution and water or an alcohol based disinfectant Do not immerse the unit in liquid 10 2 Servicing Regular servicing is not necessary Should it become necessary to repair the equipment please contact our Service Department 10 3 Replacement of spare parts Only original spare parts mentioned in these operating instructions are allowed 10 4 Other accessories There are no accessory parts for this instruments 24 Issue 06 2013 User manual BioShake series Service 11 Service Should you have any problems with this unit please contact our service department or your local Analytik Jena Biometra distributor Analytik Jena AG Service Department Life Science Konrad Zuse StraBe 1 D 07745 Jena Tel 49 0 36 44 77 94 11 Fax 49 0 36 61 77 76 77 76 e mail lifescience analytik jena com Internet www bio analytik jena com 4 Attention If you would like
4. All adapters will be automatically detected while mounting on the instrument The allocation of the adapter to a particular category determines the properties Adapter category Cat 01 Cat 02 Cat 03 Cat 04 Cat 05 Cat 06 Cat 07 Cat 10 Fig 6 7 14 Max rpm 3 000 1 800 m NO e oO 3 000 BE Available adapters 848 1808 1061 848 1808 1062 848 1808 1063 848 1808 1065 848 1808 1066 848 1808 1067 848 1808 1071 848 1808 1072 848 1808 1121 848 1808 1131 848 1808 1041 848 1808 1064 848 1808 1021 848 1808 1031 848 1808 1093 848 1808 1094 Description A Without adapter heating function not available B All non classified adapters heating function not available Adapter for 24x 2 0 ml or 15x 0 5 ml tubes Adapter for 24x 1 5 ml or 15x 0 5 ml tubes Adapter for 40x 0 5 ml or 28x 0 2 ml tubes Adapter for 35x 2 0 ml or 24x 0 5 ml tubes Adapter for 35x 1 5 ml or 24x 0 5 tubes Adapter for 35x Lysis tubes 0 5 2 0 ml Adapter for 30x 2 0 ml glass vials Adapter for 20x 4 0 ml glass vials Deep well plate adapter 96 well 1 000 ul Eppendorf Deep well plate adapter 96 well 500 ul Eppendorf Microplate adapter 96 well standard PCR plate universal Adapter for 96x 0 2 ml tubes Microplate adapter flat bottom Microplate adapter universal 96 well round bottom Adapter Falcon tubes 4 x 50 ml or 2 x 15 ml Adapter Falcon tubes 12 x 15 ml Not avai
5. arcana EE eet cece AET TE RU Ec PDT RE acer 15 6 9 ROOM ARMING eer ee el 15 6 10 Set up the time counting and temperature control mode 16 6 11 Set up the buzzer and programming control mode sssse 17 7 Tips for shaker operation 18 8 Specificallonicztzim eSI 19 8 1 Adapter for microplates tubes and glass vials sseussssse 19 8 2 Technical specification S m TC 19 9 ordering information eaae case ccs a a 21 10 Maintenance and repair e nun nun nen 24 10 1 Cleaning and MAINTENANCE ccccccceeeececceeeeeeeeceeeeeeesueeeeeeseageeeeeseageeeeseas 24 10 2 SONE O aana eex ii MAR LR bue ee E AL esu Ee LAE E EN 24 10 3 Replacement Of spare parts eaten ei 24 10 4 OINERACCESSO IE Seton dott tete ee ee 24 User manual BioShake series Issue 06 2013 1 Content 11 11 1 12 13 14 15 16 SEMVICE eM 25 Instructions for return shIpmaerlt socis ee 25 Equipment Decontamination Certificate 26 Note for disposal of electric electronic waste 27 EC Declaration of Conformity 28 ii ATEN UY isse cct 29 Table oP IgUres een 31 Issue 06 2013 User manual BioShake series Introduction 1 Introduction 1 1 Field of application The BioShake Series is sp
6. viv V STEP 7 To End press P1 or P2 u e and hold for at least 2 sec least 2 sec to the next program step TO RUN THE PROGRAM Program P1 or P2 activated START STOP deactivate Short press P1 or P2 Short press Short press If you do not press Start Short press P1 or P2 Stop the program will stop when it is finished Bg START START STOP STOP Programming BioShake iQ or BioShake XP Fig 6 8 6 10 Set up the time counting and temperature control mode The time counting function enables temperature control and or mixing for a limited period of time There are two ways to measure the time of the temperature control processes Time control Temp control Time counting begins immediately when Start Stop is pressed The Temp control mode is the standard mode Time counting only starts when the nominal temperature value has been reached To terminate the process earlier press Start Stop again Switch the TCMo mode with the following steps 1 O Y A To start press Temp and P1 and hold for at least 3 seconds Display Line 1 TCMo BMo Display Line 2 Temp auto 2 TIME Temp mode or Time mode gt e a Fam e amp i A least 3 seconds Issue 06 2013 By pressing Time or Time the shaker will switch between To finish press P1 and Temp and hold for at User manual BioShake series Operation 6 11 Set up the buzzer and programming contro
7. If the filled plate has a weight of more than 80 g then the maximum rated shaking frequency F mo di of 3 000 rpm may not be attainable with a safety stand Select a lower shaking frequency in this case However there is no risk of v Angular frequency c orbital mixing damage to the BioShake even if the weight is radius and centripetal force F are too high then the shaking action Stops due to important values for efficient mixing excessive weight or excessive shaking frequencies As soon as you reduce the frequency the unit will stand firm Maximum shaker platform load 500 g filled well plate The shaker is driven by a maintenance free brushless motor which enables silent operation and constant shaking speed independent of the load IMPORTANT NOTES e Please start even with minimal mixing frequencies to avoid overloading e Only mix in sealed tubes and plates Sample material can be flung out of open inadequately sealed or unstable tubes and plates e When working with hazardous toxic and pathogenic samples always comply with the nationally specified safety environment e Pay particular attention to personal safety gear gloves clothing glasses etc the extraction hood and the safety class of the laboratory 18 Issue 06 2013 User manual BioShake series Specification 8 Specification 8 1 Adapter for microplates tubes and glass vials Analytik Jena Biometra offers high precision adapter plates
8. maximum mixing speeds seseeeeeeeeeee 14 Mixing speed classification of adapters cccceeeccceceeeeeeeeeeeeeeeeeseeeeeeeeesaeees 14 Programming BioShake iQ or BioShake XP cccccseeeeseseesseseeesseeeeeeeeeees 16 Bloshake adaplelS uie esa ae I E EM ELLE UEM LEE 23 Issue 06 2013 31 Content Content 1 lntodu ucuon esee E IMEEM 3 1 1 giiziefei lee euo men S 3 1 2 Information on the use of this manual ussusn0s00snennonnnnnnnnnnnnnnnnnnnnennennan en 4 2 Sale INSIFUCHIONS LESSE ERITREA 5 2 1 Warning and safety symbols on the BioShake 4444444444mnnnnnnnnnnnn 5 2 2 Safety and caution information cccccceceeeeececeeeeeeeeseeeeeeseeeueeeseeeeeeeeesaaaeeeeess 5 2 9 GSS eal IVE OAL accurante an htop E E EA 7 3 Delivery Pants oor EE 8 3 1 BO SNAKE I esse nee Dee 8 3 2 BIOSHaKERP cher deme octo ee ee ee 8 4 InstallaHonss scere ei LITE e 9 5 Changing of adapter plates 10 6 operation nune e PEE EN 11 6 1 Control panel of BioShake XP seeesesssssssseseeeeeneeennnnnnnn nennen 11 6 2 Gontrol panel or Bio Sake Ocene eite aote re ated ene an Load etes co ettam ite 12 6 3 standard MUNGOMS mec Pd m 12 6 4 SOEDUD HITIO ee dm crece eee eee ere eee 13 6 5 DEL WO MINING SHEE E E 13 6 6 Set up temperalure 3 2 E een 15 6 7 SHOH IN een 15 6 8 AMO
9. the Start Stop will cause a continuous operation of the shaker A v 65 Setup mixing speed It is possible to control mixing speeds from 200 rpm up to 3 000 rpm To set the mixing speeds use the mix buttons MIX B Required mixing speeds rpm for different tubes depending on filling volume for diluted fluids Filling volume 0 2 ml tubes 0 5 ml tubes 1 5 ml tubes 2 0 ml tubes 25 96 1400 1800 1200 1600 1000 1300 1000 1300 50 1200 1500 1100 1300 1000 1200 900 1200 75 1000 1300 1000 1200 900 1100 900 1100 Fig 6 4 Required mixing speeds depending on filling volume of tubes Required mixing speeds rpm for microplates depending on filling volume well 96 for diluted fluids Filling volume 96 well 384 well 384 well 1536 well standard standard small vol standard 10 96 1800 2200 2200 2600 2800 3000 2800 3000 25 96 1600 2000 2000 2400 2400 3000 2600 3000 50 1400 1800 1800 2200 2200 2600 2400 2600 75 96 1200 1600 1600 2000 2000 2400 2200 2600 Fig 6 5 Required mixing speeds depending on filling volume of microplates User manual BioShake series Issue 06 2013 13 Operation Maximal mixing speeds rpm for microplates depending on the weight g Type Weight 1 400 2 000 2 500 3 000 Microplate 0 80g X Deep well plate 0 120g x Deep well plate 0 150 g x Deep well plate 150 300 g x Fig 6 6 Recommended maximum mixing speeds Adapter categories
10. to allow a perfect fit for all kinds of tubes vials microplates and other different disposables The adapter plates are optimized for an excellent heat transfer to the disposables and enhance the uniformity over all wells and the heat up or cool down time The exchange of adapter plates can be performed very easily within one minute If you need an adapter plate for specially shaped micro plates tubes or vials so please send us additional specific information about your used sample container manufacturer description article number You will receive your special formed adapter plate 8 2 Technical specifications BioShake XP BioShake iQ BioShake XP BioShake iQ Adapter plates Microplates 96 384 and 1536 well microplates deep well v well square well and u well shape Tubes 0 2 0 5 1 5 and 2 0 ml tubes Lysis Tubes 0 5 2 0 ml 15 ml and 50 ml Falcon tubes Glass vials 2 0 and 4 0 ml glass vials Temperature Regulation range RT to 99 C 0 1 C increment adjustable from 0 C to 99 C 0 1 C 0 5 C at 45 C 0 7 C at 75 C 1 0 C at 95 C 10 min from RT to 95 C approx 7 C min Temperature setting Regulation accuracy Temperature accuracy Heat up time Active Cool down time Mixing Mixing frequency 200 to 3 000 rpm microplates 200 to 1 800 rpm tubes glass vials Mixing orbit Constant 2 mm Speed setting resolution 50 rpm increments Mixing regulation accuracy 25 rom Timer Timer se
11. to send the unit back to us please read the following instructions 11 1 Instructions for return shipment e Return only defective devices For technical problems which are not definitively recognisable as device faults please contact the technical service department at Analytik Jena Life Science Tel 49 0 36 41 77 94 11 Fax 49 0 36 61 77 76 77 76 e mail lifescience analytik jena com e Please contact our service department for providing a return material authorization number RMA This number has to be applied clearly visible to the outer box Returns without the RMA will be not be accepted 4 Important Carefully clean all parts of the instrument from residues and of biologically dangerous chemical or radioactive contaminants If an instrument is contaminated Analytik Jena Biometra will be forced to refuse to accept the device The sender of the repair order will be held liable for possible damages and losses resulting from insufficient decontamination of the device e Please prepare written confirmation use the Equipment Decontamination Declaration following on the next page that the device is free of biologically dangerous chemical or radioactive contaminants This confirmation must be attached to the outside of the packaging e Use the original packing or a similarly robust packing when returning the device If not available contact Analytik Jena Biometra or your local distributor e Label the outsid
12. waste 27 EC Declaration of Conformity 28 ii ATEN UY isse cct 29 Table oP IgUres een 31 Issue 06 2013 User manual BioShake series Introduction 1 Introduction 1 1 Field of application The BioShake Series is special designed for precise control of speed and temperature in an apparatus with a footprint not bigger than 2 microplates side by side The apparatus offer an ultra efficient 3 dimensional shaking axis to mix samples in tubes glass vials or microplates up to 1536 wells without the need of spinning down the samples after mixing Even high density plates or low samples volumes are not a problem for the Shaker BioShake mixers have an orbit diameter of 2 0 mm and a high maximum shaking frequency of 3 000 rpm allowing any model to easily mix standard and low volume samples in tubes glass vials and 96 well 384 well or 1536 well microplates The apparatus are working very quiet due to a special patent pending dampening system which relies upon ingenious counter weight symmetry They shake tubes to mix their content but do not put vibrations on the entire work bench or robotic deck Reduced mass sample blocks provide for quick heating and accurate temperature control across the whole block Minimal frequencies rpm for starting mixing effects for different micro plates 9000 depending on a Orbital diameter 5 filling volume well for diluted fluids a
13. 4 Issue 06 2013 User manual BioShake series Safety instructions 2 Safety instructions Read through this chapter carefully prior to commissioning the BioShake Series for your own safety and for trouble free operation Follow all the safety instructions explained in the manual as well as all messages and information displayed on the screen by the internal microcomputer 2 1 Warning and safety symbols on the BioShake The following warning and safety symbols are affixed on the BioShake AN Caution Hot surface Contact with the surface can cause burns This symbol is affixed on the basis unit next to the heating surface of the block only BioShake iQ Disconnect mains plug This symbol is affixed on the rear of the device next to the mains input 2 2 Safety and caution information AA AAA 1 Do not operate the device in rooms where work is being carried out with explosive substances 2 Do not use this device to process any explosive radioactive or highly reactive substances 3 Do not use this device to process any substances which could create an explosive atmosphere 4 Danger Electric shock from damage to device power cable Danger Lethal voltages inside the device 5 Warning General hazard point 6 Warning Injury from rapidly rotating holder Injury from rapidly rotating imbalance compensation Injury from flying tubes and plates 7 Warning Injury from sample material being flung out Injury from
14. 536 well micro plate minimal working volume i c 1536 well micro plate 50 working volume co i 3 2004 Ww m c E X 384 well micro plate small volume minimal working volume 9000 Be NN 384 well micro plate small volume 50 working volume D 2 1500 1000 500 0 0 5 1 ia 20 ud gaa o4 SS 9 Go amp ba T5 G Bo 8 Bx 10 Orbit diameter mm Fig 1 1 Correlation between mixing frequencies and mixing effects in dependence on the filling level User manual BioShake series Issue 06 2013 3 Information 1 2 Information on the use of this manual The following warning and information symbols are used in this manual Danger Dangerous touch voltage Caution Warning messages alert you to a specific procedure or practice which if not followed correctly could cause personal injury Caution Hot surface Contact with the surface can cause burns Attention gt e D Caution messages refer you to procedures which if not observed could result in damage to the equipment Disconnect mains plug Note qe This information must be observed to ensure correct function of the device The following systematic approach is introduced in the manual The chapters and figures are numbered consecutively Each image has its own caption A cross reference is indicated with an arrow e g Information on the use of this manual pg 4 Working steps are numbered
15. 6 well round bottom universal Microplate adapter 96 well standard PCR plate universal Microplate adapter 384 well standard PCR plate universal ADAPTER for DEEP WELL PLATES Adapter Eppendorf deep well plate 96 1000 ul Adapter Eppendorf Deep well Plate 96 500 ul ADAPTER for TUBES Adapter 24 x 2 0 ml or 15 x 0 5 ml tubes Adapter 24 x 1 5 ml or 15 x 0 5 ml tubes Adapter 40 x 0 5 ml or 28 x 0 2 ml tubes Adapter 96 x 0 2 ml tubes Adapter 35 x 2 0 ml or 24 x 0 5 ml tubes Adapter 35 x 1 5 ml or 24 x 0 5 ml tubes Adapter 35 x Lysis tubes 0 5 2 0 ml ADAPTER for FALCON TUBES Adapter Falcon tubes 4 x 50 ml or 2 x 15 ml Adapter Falcon tubes 12 x 15 ml ADAPTER for GLASS VIALS Adapter 30 x 2 0 ml glass vials Adapter 20 x 4 0 ml glass vials CUSTOMIZED ADAPTERS Customized adapters for specifically shaped microplates tubes or vials on request All Adapters are delivered incl 3 fixation screws and screwdriver Issue 06 2013 848 1808 0505 848 1808 0555 848 1808 0565 848 1808 0506 848 1808 0556 848 1808 0566 848 1808 1021 848 1808 1022 848 1808 1031 848 1808 1041 848 1808 1051 848 1808 1121 848 1808 1131 848 1808 1061 848 1808 1062 848 1808 1063 848 1808 1064 848 1808 1065 848 1808 1066 848 1808 1067 848 1808 1093 848 1808 1094 848 1808 1071 848 1808 1072 848 1808 1000 21 Ordering information Product Order No Spare Parts P
16. Danger Lethal voltages inside the device 5 Warning General hazard point 6 Warning Injury from rapidly rotating holder Injury from rapidly rotating imbalance compensation Injury from flying tubes and plates 7 Warning Injury from sample material being flung out Injury from incorrect vortexing 8 Warning Damage due to incorrect power supply User manual BioShake series Issue 06 2013 5 Safety instructions 10 11 12 13 14 15 16 Caution Damage to the display from mechanical pressure Severe vibration Caution Damage to electronic components caused by spilled liquids Damage to electronic components from condensation Caution Poor safety due to missing operating manual Caution when using aggressive chemicals Please start even with minimal mixing frequencies to avoid overloading Only mix in sealed tubes and plates Sample material can be flung out of open inadequately sealed or unstable tubes and plates When working with hazardous toxic and pathogenic samples always comply with the nationally specified safety environment Please use the original power supply delivered by Analytik Jena Biometra Please use the original accessories recommended by Analytik Jena Biometra Pay particular attention to personal safety gear gloves clothing glasses etc the extraction hood and the safety class of the laboratory Read this section carefully and follow the instructions befo
17. EPS STEP 6 To Start press Pl Delete program Short press P1 Change values with the Short press P1 Repeat STEP 4 5 or P2 Yes No or P2 cursors as for progr stepl or P2 for program O A on k Om step Il and o Ja Change o o step Ill amm values We TE EN EI viv V STEP 7 To End press P1 or P2 u e and hold for at least 2 sec least 2 sec to the next program step TO RUN THE PROGRAM Program P1 or P2 activated START STOP deactivate Short press P1 or P2 Short press Short press If you do not press Start Short press P1 or P2 Stop the program will stop when it is finished Bg START START STOP STOP Programming BioShake iQ or BioShake XP Fig 6 8 6 10 Set up the time counting and temperature control mode The time counting function enables temperature control and or mixing for a limited period of time There are two ways to measure the time of the temperature control processes Time control Temp control Time counting begins immediately when Start Stop is pressed The Temp control mode is the standard mode Time counting only starts when the nominal temperature value has been reached To terminate the process earlier press Start Stop again Switch the TCMo mode with the following steps 1 O Y A To start press Temp and P1 and hold for at least 3 seconds Display Line 1 TCMo BMo Display Line 2 Temp auto 2 TIME Temp mode or T
18. ER for TUBES Adapter 24 x 2 0 ml or 15 x 0 5 ml tubes Adapter 24 x 1 5 ml or 15 x 0 5 ml tubes Adapter 40 x 0 5 ml or 28 x 0 2 ml tubes Adapter 96 x 0 2 ml tubes Adapter 35 x 2 0 ml or 24 x 0 5 ml tubes Adapter 35 x 1 5 ml or 24 x 0 5 ml tubes Adapter 35 x Lysis tubes 0 5 2 0 ml ADAPTER for FALCON TUBES Adapter Falcon tubes 4 x 50 ml or 2 x 15 ml Adapter Falcon tubes 12 x 15 ml ADAPTER for GLASS VIALS Adapter 30 x 2 0 ml glass vials Adapter 20 x 4 0 ml glass vials CUSTOMIZED ADAPTERS Customized adapters for specifically shaped microplates tubes or vials on request All Adapters are delivered incl 3 fixation screws and screwdriver Issue 06 2013 848 1808 0505 848 1808 0555 848 1808 0565 848 1808 0506 848 1808 0556 848 1808 0566 848 1808 1021 848 1808 1022 848 1808 1031 848 1808 1041 848 1808 1051 848 1808 1121 848 1808 1131 848 1808 1061 848 1808 1062 848 1808 1063 848 1808 1064 848 1808 1065 848 1808 1066 848 1808 1067 848 1808 1093 848 1808 1094 848 1808 1071 848 1808 1072 848 1808 1000 21 Ordering information Product Order No Spare Parts Power supply for BioShake XP 100 240 v AC 50 60 Hz 24 V DC 60 W 848 1808 9010 Power supply for BioShake iQ 100 240 V AC 50 60 Hz 24 V DC 108 W 848 1808 901 1 Power cord Europe 848 1808 9101 Power cord USA 848 1808 9110 Power cord Japan 848 1808 91 11 Fixation screws f
19. G Niederspannungsrichtlinie 2006 95 EG und der EC low voltage directive 2006 95 EC and the EG Richtlinie ber die elektromagnetische Vertr glichkeit 2004 108 EG entsprechen EC directive about the electromagnetic compatibility 2004 108 EC Quality Manager Issue 06 2013 User manual BioShake series Warranty 15 Warranty This laboratory instrument is produced with the highest practical standards of materials workmanship and design The design and manufacture of parts have been conceived with one purpose to produce units which will give satisfactory service Analytik Jena Biometra guarantees this unit to be free from defects in materials or workmanship under normal use or service for 24 month from date of shipment If during this time this unit proves defective in materials or workmanship Analytik Jena Biometra will repair or replace it free of charge if returned to us prepaid This guarantee does not cover damage in transit damage caused by carelessness misuse or neglect or unsatisfactory performance as a result of conditions beyond our control or consequential losses as a result of failure of our product Analytik Jena AG Life Science Biometra Service Department Konrad Zuse StraBe 1 Rudolf Wissell Str 14 16 D 07745 Jena D 37079 G ttingen Tel 49 0 36 41 77 94 00 Tel 49 0 5 51 50 68 6 10 or 12 Fax 49 0 36 61 77 76 77 76 Fax 49 0 5 51 5068 6 11 e mail lifescience analytik jena com e mail serv
20. M ELLE UEM LEE 23 Issue 06 2013 31
21. P2 Program capacity 3 steps internal memory Display Display 2 x 16 digits LCD display with backlight black Target values actual values Time mixing frequency temperature Electrical Operating voltages 24 V DC input 100 Watt Power supply External power supply unit 100 240 V AC 50 60 Hz Properties Housing material Aluminum anodized silver Operating range 5 C to 45 C 80 96 max relative humidity Dimensions WxDxH mm 142 x 170 x 80 Weight kl 27 Technical specifications are subject to change 20 Issue 06 2013 User manual BioShake series Ordering information 9 Ordering information Order No User manual BioShake series Product BioShake XP 100 240V EU plug without adapter plate BioShake XP 100 240 V US plug without adapter plate BioShake XP 100 240 V Japan plug without adapter plate BioShake iQ 100 240V EU plug without adapter plate BioShake iQ 100 240 V US plug without adapter plate BioShake iQ 100 240 V Japan plug without adapter plate ADAPTER for MICROPLATES Microplate adapter Flat bottom Microplate adapter flat bottom high base universal Microplate adapter 96 well round bottom universal Microplate adapter 96 well standard PCR plate universal Microplate adapter 384 well standard PCR plate universal ADAPTER for DEEP WELL PLATES Adapter Eppendorf deep well plate 96 1000 ul Adapter Eppendorf Deep well Plate 96 500 ul ADAPT
22. Shaker Herewith we declare that the following Shakers Typ type BioShake XP BioShake iQ Best Nr Order No 848 1808 0505 848 1808 0555 848 1808 0565 848 1808 0506 848 1808 0556 848 1808 0566 den grundlegenden Anforderungen der corresponds to the basic requirements of EG Niederspannungsrichtlinie 2006 95 EG und der EC low voltage directive 2006 95 EC and the EG Richtlinie ber die elektromagnetische Vertr glichkeit 2004 108 EG entsprechen EC directive about the electromagnetic compatibility 2004 108 EC Quality Manager Issue 06 2013 User manual BioShake series Warranty 15 Warranty This laboratory instrument is produced with the highest practical standards of materials workmanship and design The design and manufacture of parts have been conceived with one purpose to produce units which will give satisfactory service Analytik Jena Biometra guarantees this unit to be free from defects in materials or workmanship under normal use or service for 24 month from date of shipment If during this time this unit proves defective in materials or workmanship Analytik Jena Biometra will repair or replace it free of charge if returned to us prepaid This guarantee does not cover damage in transit damage caused by carelessness misuse or neglect or unsatisfactory performance as a result of conditions beyond our control or consequential losses as a result of failure of our product Analytik Jena AG Life Sc
23. XP The following picture shows the control panel of the BioShake XP Display 1 line Target Values TIME MIXING SPEED Display 2 line Actual Values min sec rom Short Mix Button min sec BioShake XP life science unlimited Time Mix Program Start Stop Cursor Cursor Buttons Button Fig 6 1 Control panel of BioShake XP User manual BioShake series Issue 06 2013 11 Operation 6 2 Control panel of BioShake iQ Display 1 line Target Values TIME MIXING SPEED TEMPERATURE Display 2 line Actual Values min sec rom PC Short Mix Button min sec BioShake IQ life science unlimited Time Mix Temperature Program Start Stop Cursor Cursor Cursor Buttons Button Fig 6 2 Control panel of BioShake iQ 6 3 Standard functions STANDARD FUNCTIONS E A gt Feature Change value Time Mixing speed Temperature aS Fig 6 3 Standard functions only for BioShake iQ and BioShake XP Issue 06 2013 User manual BioShake series Operation 6 4 Setup time Use time cursors to set the required operation time If the timer is not selected pressing the Start Stop will cause a continuous operation of the shaker A v 65 Setup mixing speed It is possible to control mixing speeds from 200 rpm up to 3 000 rpm To set the mixing speeds use the mix buttons MIX B Required mixing speeds rpm for different tubes depend
24. an adapter plate already be mounted please remove it 5 first 1 2 3 4 Turn off the instrument Remove all sample carriers B 3 tubes vials microplates etc Loosen the 3 torx screws A 1 A 2 and A 3 by using the supplied screwdriver Torx size 8 rotate left Take off the cover clate or adapter plate B 2 straight up and put it on a clean soft surface Mounting of the new adapter plate 1 Please take care to a clean dirt free and particle free operation 2 Insert the new adapter plate straight into the impression of the plate holder B 1 3 Check the fixed position 4 Fixall torx screws A 1 A 2 und A 3 using clockwise rotation Please take care to uniform controlled tightening of screws to ensure a good fit 5 Please take care to good and tight fit of sample carriers B 3 tubes vials microplates etc 6 Turnon the instrument BioShake will recognize the different block types All pending information and indications are shown in the display N Fig 5 1 Mounting of adapter plates A Attention Heavier blocks may limit the shaking speed see Fig 6 6 Recommended maximum mixing speeds Issue 06 2013 User manual BioShake series Operation 6 Operation The BioShake is designed for shaking BioShake iQ and BioShake XP and temperature control BioShake iQ of liquids in tissue culture plates microplates tubes and glass vials Microplates or tubes have to be placed on the shaker platfor
25. analytikjena BioShake Series Shaker and thermal mixer analytikjena Analytik Jena Lifescience Konrad Zuse Str 1 07745 Jena Phone Hotline 49 3641 77 94 00 Fax 49 3641 77 76 77 76 e mail lifescience analytik jena de General information about Analytik Jena AG on the internet http www bio analytik jena de Edition June 2013 Technical documentation made by Analytik Jena This documentation describes the state of this product at the time of publishing It need not necessarily agree with future versions of the product oubject to change Copyright 2013 Analytik Jena Content Content 1 lntodu ucuon esee E IMEEM 3 1 1 giiziefei lee euo men S 3 1 2 Information on the use of this manual ussusn0s00snennonnnnnnnnnnnnnnnnnnnnennennan en 4 2 Sale INSIFUCHIONS LESSE ERITREA 5 2 1 Warning and safety symbols on the BioShake 4444444444mnnnnnnnnnnnn 5 2 2 Safety and caution information cccccceceeeeececeeeeeeeeseeeeeeseeeueeeseeeeeeeeesaaaeeeeess 5 2 9 GSS eal IVE OAL accurante an htop E E EA 7 3 Delivery Pants oor EE 8 3 1 BO SNAKE I esse nee Dee 8 3 2 BIOSHaKERP cher deme octo ee ee ee 8 4 InstallaHonss scere ei LITE e 9 5 Changing of adapter plates 10 6 operation nune e PEE EN 11 6 1 Control panel of BioShake XP seeesesssssssseseeeeeneeen
26. e of the box with CAUTION SENSITIVE INSTRUMENT and the RAN number sticker Attach the Decontamination Declaration e Please enclose a note which contains the following a Sender s name and address b Name of a contact person for further inquiries with telephone number c Precise description of the fault which also reveals during which procedures the fault occurred if possible User manual BioShake series Issue 06 2013 25 Equipment Decontamination Certificate 26 12 Equipment Decontamination Certificate To enable us to comply with german law i e 71 StrlSchV 17 GefStoffV and 819 ChemG and to avoid exposure to hazardous materials during handling or repair please complete this form prior to the equipment leaving your laboratory COMPANY INSTITUTE ADRESS PHONE NO FAXNO E MAIL EQUIPMENT MODEL SERIAL NO If on loan evaluation Start date Finish date Hazardous material used with this equipment Method of cleaning decontamination The equipment has been cleaned and decontaminated HEAD OF DIV DEP INSTITUTE COMPANY SIGNED DATE PLEASE RETURN THIS FORM TO ANALYTIK JENA BIOMETRA OR YOUR LOCAL ANLYTIK JENA BIOMETRA DISTRIBUTOR TOGETHER WITH THE EQUIPMENT PLEASE ATTACH THIS CERTIFICATE OUTSIDE THE PACKAGING INSTRUMENTS WITHOUT THIS CERTIFICATE ATTACHED WILL BE RETURNED TO SENDER General Information for Decontamination Please contact your responsible health amp safe
27. e or missing items to your local distributor If no damage is found place the device up on a stable horizontal surface Power supply On Off DC 24 V Fig 4 1 Connections at the rear side of device BioShake iQ and BioShake XP Before starting to work with the BioShake Remove the cover plate before installing an adapter plate Loose the 3 torx screws with the torx screwer at the adapter packaging and remove the cover plate If the adapter will not be removed before installing an adapter the adapter will not be recognized by the device Place an adapter on the shaker chapter 5 Changing of adapter plates Plug the external power supply 2 into the 24 V socket at the rear side of the BioShake iQ or BioShake XP Plug the power cable 3 into the power supply 2 and into the wall socket Turn On the instrument It is advisable to carry out a test run at maximum speed to ensure that the device does not move while mixing User manual BioShake series Issue 06 2013 9 Changing of adapter plates Changing of adapter plates To change the adapter plates please follow the subsequent steps Attention If the security cover plate or an adapter plate already be mounted please remove it 5 first 1 2 3 4 Turn off the instrument Remove all sample carriers B 3 tubes vials microplates etc Loosen the 3 torx screws A 1 A 2 and A 3 by using the supplied screwdriver Torx size 8 rotate left Take off
28. ecial designed for precise control of speed and temperature in an apparatus with a footprint not bigger than 2 microplates side by side The apparatus offer an ultra efficient 3 dimensional shaking axis to mix samples in tubes glass vials or microplates up to 1536 wells without the need of spinning down the samples after mixing Even high density plates or low samples volumes are not a problem for the Shaker BioShake mixers have an orbit diameter of 2 0 mm and a high maximum shaking frequency of 3 000 rpm allowing any model to easily mix standard and low volume samples in tubes glass vials and 96 well 384 well or 1536 well microplates The apparatus are working very quiet due to a special patent pending dampening system which relies upon ingenious counter weight symmetry They shake tubes to mix their content but do not put vibrations on the entire work bench or robotic deck Reduced mass sample blocks provide for quick heating and accurate temperature control across the whole block Minimal frequencies rpm for starting mixing effects for different micro plates 9000 depending on a Orbital diameter 5 filling volume well for diluted fluids at 20 C 4500 96 well micro plate minimal working volume BE RE 96 well micro plate 50 working volume 3500 384 well micro plate minimal working volume B X X BioShake iQ XP 384 well micro plate 50 working volume e 3000 X Prien e 1
29. ecise description of the fault which also reveals during which procedures the fault occurred if possible User manual BioShake series Issue 06 2013 25 Equipment Decontamination Certificate 26 12 Equipment Decontamination Certificate To enable us to comply with german law i e 71 StrlSchV 17 GefStoffV and 819 ChemG and to avoid exposure to hazardous materials during handling or repair please complete this form prior to the equipment leaving your laboratory COMPANY INSTITUTE ADRESS PHONE NO FAXNO E MAIL EQUIPMENT MODEL SERIAL NO If on loan evaluation Start date Finish date Hazardous material used with this equipment Method of cleaning decontamination The equipment has been cleaned and decontaminated HEAD OF DIV DEP INSTITUTE COMPANY SIGNED DATE PLEASE RETURN THIS FORM TO ANALYTIK JENA BIOMETRA OR YOUR LOCAL ANLYTIK JENA BIOMETRA DISTRIBUTOR TOGETHER WITH THE EQUIPMENT PLEASE ATTACH THIS CERTIFICATE OUTSIDE THE PACKAGING INSTRUMENTS WITHOUT THIS CERTIFICATE ATTACHED WILL BE RETURNED TO SENDER General Information for Decontamination Please contact your responsible health amp safety officer for details Use of radioactive substances Please contact your responsible person for details Use of genetically change organism or parts of those Please contact your responsible person for details Issue 06 2013 User manual BioShake series Note for disposal of elec
30. enance and repair 10 4 Cleaning and maintenance The device is maintenance free Before cleaning the BioShake disconnect the power cord and make sure that the temperature at the contact surface is below 40 C If contaminated the device may be cleaned using a mild soap solution and water or an alcohol based disinfectant Do not immerse the unit in liquid 10 2 Servicing Regular servicing is not necessary Should it become necessary to repair the equipment please contact our Service Department 10 3 Replacement of spare parts Only original spare parts mentioned in these operating instructions are allowed 10 4 Other accessories There are no accessory parts for this instruments 24 Issue 06 2013 User manual BioShake series Service 11 Service Should you have any problems with this unit please contact our service department or your local Analytik Jena Biometra distributor Analytik Jena AG Service Department Life Science Konrad Zuse StraBe 1 D 07745 Jena Tel 49 0 36 44 77 94 11 Fax 49 0 36 61 77 76 77 76 e mail lifescience analytik jena com Internet www bio analytik jena com 4 Attention If you would like to send the unit back to us please read the following instructions 11 1 Instructions for return shipment e Return only defective devices For technical problems which are not definitively recognisable as device faults please contact the technical service department at Analytik Jena Li
31. er supply the power cord and different blocks Do not make any mechanical or electrical modifications to the equipment Never do anything else with BioShake as intended in this manual Noncompliance of the safety instructions may lead to device damage loss of warranty and may cause serious personal injury as well as death General information User manual BioShake series Warning Injury from sample material being flung out Sample material can be flung out of open inadequately sealed or unstable wells plates and tubes e Only mix in sealed tubes and plates e When working with hazardous toxic and pathogenic samples always comply with nationally specified safety environment Pay particular attention to personal safety gear gloves clothing glasses etc the extraction hood and the safety class of the laboratory When setting mixing frequency adhere to the rules outlined in Fig 6 4 to 6 7 Issue 06 2013 7 Delivery parts 3 Delivery parts 3 1 BioShake iQ 1 BioShake iQ mM 2 Power supply 3 Power cord Operating manual no picture Fig 3 1 BioShake iQ 1 with power supply 2 and power cord 3 3 2 BioShake XP 1 BioShake iQ 2 Power supply 3 Power cord Operating manual no picture Fig 3 2 BioShake XP 1 with power supply 2 and power cord 3 8 Issue 06 2013 User manual BioShake series Installation 4 Installation Unpack and carefully check the instrument Report any damag
32. es can be performed very easily within one minute If you need an adapter plate for specially shaped micro plates tubes or vials so please send us additional specific information about your used sample container manufacturer description article number You will receive your special formed adapter plate 8 2 Technical specifications BioShake XP BioShake iQ BioShake XP BioShake iQ Adapter plates Microplates 96 384 and 1536 well microplates deep well v well square well and u well shape Tubes 0 2 0 5 1 5 and 2 0 ml tubes Lysis Tubes 0 5 2 0 ml 15 ml and 50 ml Falcon tubes Glass vials 2 0 and 4 0 ml glass vials Temperature Regulation range RT to 99 C 0 1 C increment adjustable from 0 C to 99 C 0 1 C 0 5 C at 45 C 0 7 C at 75 C 1 0 C at 95 C 10 min from RT to 95 C approx 7 C min Temperature setting Regulation accuracy Temperature accuracy Heat up time Active Cool down time Mixing Mixing frequency 200 to 3 000 rpm microplates 200 to 1 800 rpm tubes glass vials Mixing orbit Constant 2 mm Speed setting resolution 50 rpm increments Mixing regulation accuracy 25 rom Timer Timer setting 1 min 99 h with automatic switch to stand by Working Alarm Continuous working audible alarm User manual BioShake series Issue 06 2013 19 Specification BioShake XP BioShake iQ Programming Operation control Micro controller Programs 2 programs definable buttons P1 and
33. fe Science Tel 49 0 36 41 77 94 11 Fax 49 0 36 61 77 76 77 76 e mail lifescience analytik jena com e Please contact our service department for providing a return material authorization number RMA This number has to be applied clearly visible to the outer box Returns without the RMA will be not be accepted 4 Important Carefully clean all parts of the instrument from residues and of biologically dangerous chemical or radioactive contaminants If an instrument is contaminated Analytik Jena Biometra will be forced to refuse to accept the device The sender of the repair order will be held liable for possible damages and losses resulting from insufficient decontamination of the device e Please prepare written confirmation use the Equipment Decontamination Declaration following on the next page that the device is free of biologically dangerous chemical or radioactive contaminants This confirmation must be attached to the outside of the packaging e Use the original packing or a similarly robust packing when returning the device If not available contact Analytik Jena Biometra or your local distributor e Label the outside of the box with CAUTION SENSITIVE INSTRUMENT and the RAN number sticker Attach the Decontamination Declaration e Please enclose a note which contains the following a Sender s name and address b Name of a contact person for further inquiries with telephone number c Pr
34. ice biometra com Internet www bio analytik jena com Internet www bio analytik jena com User manual BioShake series Issue 06 2013 29 16 Fig Fig Fig Fig Fig Fig Fig Fig Fig Fig Fig Fig Fig Fig User manual BioShake series E 3 1 3 2 4 1 5 1 6 1 6 2 6 3 6 4 6 5 6 6 6 7 6 8 9 1 Table of figures Table of figures Correlation between mixing frequencies and mixing effects in dependence Oden OVE iki a ee a ee EE 3 BioShake iQ 1 with power supply 2 and power cord 3 8 BioShake XP 1 with power supply 2 and power cord 3 8 Connections at the rear side of device BioShake iQ and BioShake XP 9 Mounting of adapter plates cccccccccccsseeeeeceeseeeeeeseeeeeeeeseaeeeeeeseaeeeessaeanes 10 Control panel of BioShake XP riere e nennen nnns 11 Gontrol panel or BloShake1 Reel 12 Standard functions only for BioShake iQ and BioShake XP 12 Required mixing speeds depending on filling volume of tubes 13 Required mixing speeds depending on filling volume of microplates 13 Recommended maximum mixing speeds seseeeeeeeeeee 14 Mixing speed classification of adapters cccceeeccceceeeeeeeeeeeeeeeeeseeeeeeeeesaeees 14 Programming BioShake iQ or BioShake XP cccccseeeeseseesseseeesseeeeeeeeeees 16 Bloshake adaplelS uie esa ae I E E
35. ience Biometra Service Department Konrad Zuse StraBe 1 Rudolf Wissell Str 14 16 D 07745 Jena D 37079 G ttingen Tel 49 0 36 41 77 94 00 Tel 49 0 5 51 50 68 6 10 or 12 Fax 49 0 36 61 77 76 77 76 Fax 49 0 5 51 5068 6 11 e mail lifescience analytik jena com e mail service biometra com Internet www bio analytik jena com Internet www bio analytik jena com User manual BioShake series Issue 06 2013 29 16 Fig Fig Fig Fig Fig Fig Fig Fig Fig Fig Fig Fig Fig Fig User manual BioShake series E 3 1 3 2 4 1 5 1 6 1 6 2 6 3 6 4 6 5 6 6 6 7 6 8 9 1 Table of figures Table of figures Correlation between mixing frequencies and mixing effects in dependence Oden OVE iki a ee a ee EE 3 BioShake iQ 1 with power supply 2 and power cord 3 8 BioShake XP 1 with power supply 2 and power cord 3 8 Connections at the rear side of device BioShake iQ and BioShake XP 9 Mounting of adapter plates cccccccccccsseeeeeceeseeeeeeseeeeeeeeseaeeeeeeseaeeeessaeanes 10 Control panel of BioShake XP riere e nennen nnns 11 Gontrol panel or BloShake1 Reel 12 Standard functions only for BioShake iQ and BioShake XP 12 Required mixing speeds depending on filling volume of tubes 13 Required mixing speeds depending on filling volume of microplates 13 Recommended
36. ime mode gt e a Fam e amp i A least 3 seconds Issue 06 2013 By pressing Time or Time the shaker will switch between To finish press P1 and Temp and hold for at User manual BioShake series Operation 6 11 Set up the buzzer and programming control mode The programming control mode enables buzzer and temperature control at the end of automatic programs There are two ways to set up the buzzer and temperature control process auto mode At the end of automatic e 3x short buzzer signals programs e Mixing is stopped e Temperature control is stopped and switch off User mode At the end of automatic e Short buzzer signal every 10 seconds programs e Mixing is stopped e Temperature control is enabled and keep target temperature constant Switch the BMo mode with the following steps To start press Temp and P1 and hold for at least 3 seconds Display Line 1 TCMo BMo Display Line 2 Temp auto By pressing Mix or Mix the shaker will switch between auto mode or user mode To finish press P1 and Temp and hold for at least 3 seconds User manual BioShake series Issue 06 2013 17 Tips for shaker operation 7 Tips for shaker operation A wide variety of well plates are commercially available Sir Isaac Newton anno 1687 To ensure that the plates are positioned securely in the plate holder they must E gt correspond with the ANIS SBS Standard for OZ mf Microplates
37. incorrect vortexing 8 Warning Damage due to incorrect power supply User manual BioShake series Issue 06 2013 5 Safety instructions 10 11 12 13 14 15 16 Caution Damage to the display from mechanical pressure Severe vibration Caution Damage to electronic components caused by spilled liquids Damage to electronic components from condensation Caution Poor safety due to missing operating manual Caution when using aggressive chemicals Please start even with minimal mixing frequencies to avoid overloading Only mix in sealed tubes and plates Sample material can be flung out of open inadequately sealed or unstable tubes and plates When working with hazardous toxic and pathogenic samples always comply with the nationally specified safety environment Please use the original power supply delivered by Analytik Jena Biometra Please use the original accessories recommended by Analytik Jena Biometra Pay particular attention to personal safety gear gloves clothing glasses etc the extraction hood and the safety class of the laboratory Read this section carefully and follow the instructions before beginning installation and any procedure The unit must be placed on a horizontal solid work space The device must be saving from shocks and falling The unit must be placed in sufficient distance to heat registers or radiators to ensure ambient temperature conditions in accordance
38. ing on filling volume for diluted fluids Filling volume 0 2 ml tubes 0 5 ml tubes 1 5 ml tubes 2 0 ml tubes 25 96 1400 1800 1200 1600 1000 1300 1000 1300 50 1200 1500 1100 1300 1000 1200 900 1200 75 1000 1300 1000 1200 900 1100 900 1100 Fig 6 4 Required mixing speeds depending on filling volume of tubes Required mixing speeds rpm for microplates depending on filling volume well 96 for diluted fluids Filling volume 96 well 384 well 384 well 1536 well standard standard small vol standard 10 96 1800 2200 2200 2600 2800 3000 2800 3000 25 96 1600 2000 2000 2400 2400 3000 2600 3000 50 1400 1800 1800 2200 2200 2600 2400 2600 75 96 1200 1600 1600 2000 2000 2400 2200 2600 Fig 6 5 Required mixing speeds depending on filling volume of microplates User manual BioShake series Issue 06 2013 13 Operation Maximal mixing speeds rpm for microplates depending on the weight g Type Weight 1 400 2 000 2 500 3 000 Microplate 0 80g X Deep well plate 0 120g x Deep well plate 0 150 g x Deep well plate 150 300 g x Fig 6 6 Recommended maximum mixing speeds Adapter categories All adapters will be automatically detected while mounting on the instrument The allocation of the adapter to a particular category determines the properties Adapter category Cat 01 Cat 02 Cat 03 Cat 04 Cat 05 Cat 06 Cat 07 Cat 10 Fig 6 7 14 Max rpm
39. l mode The programming control mode enables buzzer and temperature control at the end of automatic programs There are two ways to set up the buzzer and temperature control process auto mode At the end of automatic e 3x short buzzer signals programs e Mixing is stopped e Temperature control is stopped and switch off User mode At the end of automatic e Short buzzer signal every 10 seconds programs e Mixing is stopped e Temperature control is enabled and keep target temperature constant Switch the BMo mode with the following steps To start press Temp and P1 and hold for at least 3 seconds Display Line 1 TCMo BMo Display Line 2 Temp auto By pressing Mix or Mix the shaker will switch between auto mode or user mode To finish press P1 and Temp and hold for at least 3 seconds User manual BioShake series Issue 06 2013 17 Tips for shaker operation 7 Tips for shaker operation A wide variety of well plates are commercially available Sir Isaac Newton anno 1687 To ensure that the plates are positioned securely in the plate holder they must E gt correspond with the ANIS SBS Standard for OZ mf Microplates If the filled plate has a weight of more than 80 g then the maximum rated shaking frequency F mo di of 3 000 rpm may not be attainable with a safety stand Select a lower shaking frequency in this case However there is no risk of v Angular frequency c orbital mixing damage
40. lable at the time 848 1808 1022 848 1808 1051 Customer specified Microplate adapter flat bottom high base Microplate adapter 384 well standard PCR plates Mixing speed classification of adapters Issue 06 2013 User manual BioShake series Operation All pending information and indications are shown in the display Display Line 1 Adapter Cat 01 Display Line 2 Max Speed 3000 6 6 Setup temperature It is possible to control temperature from room temperature up to 99 C To set the temperature use the Temp Buttons TEMP A v A Attention Microplates melt at extremely high temperatures Only heat microplates made of polystyrene to a maximum of 70 C 6 7 Short mix O By pressing Short Mix the shaker will start up with the set ED parameters Releasing the Short Mix button will stop the shaker 6 8 Start Stop i By pressing Start Stop the shaker will start up with the set START parameters STOP If you press Start Stop again the shaker will stop 6 9 Programming With the BioShake iQ and BioShake XP it is possible to have 2 automatic programs Both programs can have 3 different steps with different time speed and temperature settings for each step User manual BioShake series Issue 06 2013 15 Operation Program the BioShake iQ or BioShake XP with the following steps PROGRAMMING P1 and P2 and hold forat mm to go forward cursors STEP 1 STEP 2 SIEP 3 SIEPZ ST
41. llowing systematic approach is introduced in the manual The chapters and figures are numbered consecutively Each image has its own caption A cross reference is indicated with an arrow e g Information on the use of this manual pg 4 Working steps are numbered 4 Issue 06 2013 User manual BioShake series Safety instructions 2 Safety instructions Read through this chapter carefully prior to commissioning the BioShake Series for your own safety and for trouble free operation Follow all the safety instructions explained in the manual as well as all messages and information displayed on the screen by the internal microcomputer 2 1 Warning and safety symbols on the BioShake The following warning and safety symbols are affixed on the BioShake AN Caution Hot surface Contact with the surface can cause burns This symbol is affixed on the basis unit next to the heating surface of the block only BioShake iQ Disconnect mains plug This symbol is affixed on the rear of the device next to the mains input 2 2 Safety and caution information AA AAA 1 Do not operate the device in rooms where work is being carried out with explosive substances 2 Do not use this device to process any explosive radioactive or highly reactive substances 3 Do not use this device to process any substances which could create an explosive atmosphere 4 Danger Electric shock from damage to device power cable
42. m of the BioShake The liquid to be shaken is introduced into the wells or tubes The automatic start up function of the unit ensures a gradual start of the shaking process without sample splashing The drive is absolutely wear free and maintenance free 6 1 Control panel of BioShake XP The following picture shows the control panel of the BioShake XP Display 1 line Target Values TIME MIXING SPEED Display 2 line Actual Values min sec rom Short Mix Button min sec BioShake XP life science unlimited Time Mix Program Start Stop Cursor Cursor Buttons Button Fig 6 1 Control panel of BioShake XP User manual BioShake series Issue 06 2013 11 Operation 6 2 Control panel of BioShake iQ Display 1 line Target Values TIME MIXING SPEED TEMPERATURE Display 2 line Actual Values min sec rom PC Short Mix Button min sec BioShake IQ life science unlimited Time Mix Temperature Program Start Stop Cursor Cursor Cursor Buttons Button Fig 6 2 Control panel of BioShake iQ 6 3 Standard functions STANDARD FUNCTIONS E A gt Feature Change value Time Mixing speed Temperature aS Fig 6 3 Standard functions only for BioShake iQ and BioShake XP Issue 06 2013 User manual BioShake series Operation 6 4 Setup time Use time cursors to set the required operation time If the timer is not selected pressing
43. nnnnnnn nennen 11 6 2 Gontrol panel or Bio Sake Ocene eite aote re ated ene an Load etes co ettam ite 12 6 3 standard MUNGOMS mec Pd m 12 6 4 SOEDUD HITIO ee dm crece eee eee ere eee 13 6 5 DEL WO MINING SHEE E E 13 6 6 Set up temperalure 3 2 E een 15 6 7 SHOH IN een 15 6 8 AMO arcana EE eet cece AET TE RU Ec PDT RE acer 15 6 9 ROOM ARMING eer ee el 15 6 10 Set up the time counting and temperature control mode 16 6 11 Set up the buzzer and programming control mode sssse 17 7 Tips for shaker operation 18 8 Specificallonicztzim eSI 19 8 1 Adapter for microplates tubes and glass vials sseussssse 19 8 2 Technical specification S m TC 19 9 ordering information eaae case ccs a a 21 10 Maintenance and repair e nun nun nen 24 10 1 Cleaning and MAINTENANCE ccccccceeeececceeeeeeeeceeeeeeesueeeeeeseageeeeeseageeeeseas 24 10 2 SONE O aana eex ii MAR LR bue ee E AL esu Ee LAE E EN 24 10 3 Replacement Of spare parts eaten ei 24 10 4 OINERACCESSO IE Seton dott tete ee ee 24 User manual BioShake series Issue 06 2013 1 Content 11 11 1 12 13 14 15 16 SEMVICE eM 25 Instructions for return shIpmaerlt socis ee 25 Equipment Decontamination Certificate 26 Note for disposal of electric electronic
44. or Security Cover Plate or Adapter 3 pcs 848 1808 9006 Fixation springs for BioShake XP iQ 8 pcs 848 1808 9007 Security Cover Plate incl 3 fixation screws and tool 848 1808 9008 Please use the original accessories recommended by Analytik Jena Biometra Using spare parts or disposables which we have not recommended can reduce the precision accuracy and life of the BioShake We do not honour any warranty or accept any responsibility for damage resulting from such action 22 Issue 06 2013 User manual BioShake series Ordering information Adapters for microplates MTP N iL E i Ths FR lm Vom Ve Vos Faia T ms Tem ER al SSS JUJuUUUUVUL JUUM Flat bottom high base Flat bottom high base 96 well round bottom universal 96 well standard PCR plate Adapters for deep well plates DH AU UN 384 well standard PCR plate 96 well 1 000 ul Eppendorf 96 well 500 ul Eppendorf Adapters for tubes z221i Biniainiaia EEE IL IL e HT 24x2 0 ml and 15x0 5 ml 24x 1 5 ml and 15x0 5 ml 40x0 5 ml and 28x0 2 ml 96x02 ml f n i l UU UU r 35x2 0 ml and 24 x 0 5 ml 35x1 5 ml and 24x0 5 ml 35xlysis Tubes 0 5 2 0 ml Adapters for glass vials Customized Adapters OLEI UO 30x2 0ml 20x40ml For individual reaction vessels Fig 9 1 BioShake adapters User manual BioShake series Issue 06 2013 23 Maintenance and repair 10 Maint
45. ower supply for BioShake XP 100 240 v AC 50 60 Hz 24 V DC 60 W 848 1808 9010 Power supply for BioShake iQ 100 240 V AC 50 60 Hz 24 V DC 108 W 848 1808 901 1 Power cord Europe 848 1808 9101 Power cord USA 848 1808 9110 Power cord Japan 848 1808 91 11 Fixation screws for Security Cover Plate or Adapter 3 pcs 848 1808 9006 Fixation springs for BioShake XP iQ 8 pcs 848 1808 9007 Security Cover Plate incl 3 fixation screws and tool 848 1808 9008 Please use the original accessories recommended by Analytik Jena Biometra Using spare parts or disposables which we have not recommended can reduce the precision accuracy and life of the BioShake We do not honour any warranty or accept any responsibility for damage resulting from such action 22 Issue 06 2013 User manual BioShake series Ordering information Adapters for microplates MTP N iL E i Ths FR lm Vom Ve Vos Faia T ms Tem ER al SSS JUJuUUUUVUL JUUM Flat bottom high base Flat bottom high base 96 well round bottom universal 96 well standard PCR plate Adapters for deep well plates DH AU UN 384 well standard PCR plate 96 well 1 000 ul Eppendorf 96 well 500 ul Eppendorf Adapters for tubes z221i Biniainiaia EEE IL IL e HT 24x2 0 ml and 15x0 5 ml 24x 1 5 ml and 15x0 5 ml 40x0 5 ml and 28x0 2 ml 96x02 ml f n i l UU UU r 35x2 0 ml and 24 x 0 5 ml
46. re beginning installation and any procedure The unit must be placed on a horizontal solid work space The device must be saving from shocks and falling The unit must be placed in sufficient distance to heat registers or radiators to ensure ambient temperature conditions in accordance with the technical specifications section 8 2 Use the normal care and precaution one would use with any electrical appliance Be sure to use a power cord with the same rating and of the same type three wire with neutral conductor as the one supplied with the instrument Ensure that voltage and frequency of your power source match the input voltage and frequency inscribed on the electrical rating label of the power supply AC DC adaptor and that the output voltage matches the rating of the equipment The AC DC adaptor is designed to work with a single phase power system having a grounded neutral conductor If you are not sure what type of power is supplied to your building contact your facilities manager As BioShake is an electrical device do not spill large quantities of liquid onto the device Do not use it in an explosive atmosphere As parts of the device may generate electric magnetic or electromagnetic fields keep parts away that may be affected e g data storage units Issue 06 2013 User manual BioShake series Safety instructions BioShake is capable of heating the plate surface up to 100 C This temperature is high enough to ca
47. t 20 C 4500 96 well micro plate minimal working volume BE RE 96 well micro plate 50 working volume 3500 384 well micro plate minimal working volume B X X BioShake iQ XP 384 well micro plate 50 working volume e 3000 X Prien e 1536 well micro plate minimal working volume i c 1536 well micro plate 50 working volume co i 3 2004 Ww m c E X 384 well micro plate small volume minimal working volume 9000 Be NN 384 well micro plate small volume 50 working volume D 2 1500 1000 500 0 0 5 1 ia 20 ud gaa o4 SS 9 Go amp ba T5 G Bo 8 Bx 10 Orbit diameter mm Fig 1 1 Correlation between mixing frequencies and mixing effects in dependence on the filling level User manual BioShake series Issue 06 2013 3 Information 1 2 Information on the use of this manual The following warning and information symbols are used in this manual Danger Dangerous touch voltage Caution Warning messages alert you to a specific procedure or practice which if not followed correctly could cause personal injury Caution Hot surface Contact with the surface can cause burns Attention gt e D Caution messages refer you to procedures which if not observed could result in damage to the equipment Disconnect mains plug Note qe This information must be observed to ensure correct function of the device The fo
48. the cover clate or adapter plate B 2 straight up and put it on a clean soft surface Mounting of the new adapter plate 1 Please take care to a clean dirt free and particle free operation 2 Insert the new adapter plate straight into the impression of the plate holder B 1 3 Check the fixed position 4 Fixall torx screws A 1 A 2 und A 3 using clockwise rotation Please take care to uniform controlled tightening of screws to ensure a good fit 5 Please take care to good and tight fit of sample carriers B 3 tubes vials microplates etc 6 Turnon the instrument BioShake will recognize the different block types All pending information and indications are shown in the display N Fig 5 1 Mounting of adapter plates A Attention Heavier blocks may limit the shaking speed see Fig 6 6 Recommended maximum mixing speeds Issue 06 2013 User manual BioShake series Operation 6 Operation The BioShake is designed for shaking BioShake iQ and BioShake XP and temperature control BioShake iQ of liquids in tissue culture plates microplates tubes and glass vials Microplates or tubes have to be placed on the shaker platform of the BioShake The liquid to be shaken is introduced into the wells or tubes The automatic start up function of the unit ensures a gradual start of the shaking process without sample splashing The drive is absolutely wear free and maintenance free 6 1 Control panel of BioShake
49. tion and indications are shown in the display Display Line 1 Adapter Cat 01 Display Line 2 Max Speed 3000 6 6 Setup temperature It is possible to control temperature from room temperature up to 99 C To set the temperature use the Temp Buttons TEMP A v A Attention Microplates melt at extremely high temperatures Only heat microplates made of polystyrene to a maximum of 70 C 6 7 Short mix O By pressing Short Mix the shaker will start up with the set ED parameters Releasing the Short Mix button will stop the shaker 6 8 Start Stop i By pressing Start Stop the shaker will start up with the set START parameters STOP If you press Start Stop again the shaker will stop 6 9 Programming With the BioShake iQ and BioShake XP it is possible to have 2 automatic programs Both programs can have 3 different steps with different time speed and temperature settings for each step User manual BioShake series Issue 06 2013 15 Operation Program the BioShake iQ or BioShake XP with the following steps PROGRAMMING P1 and P2 and hold forat mm to go forward cursors STEP 1 STEP 2 SIEP 3 SIEPZ STEPS STEP 6 To Start press Pl Delete program Short press P1 Change values with the Short press P1 Repeat STEP 4 5 or P2 Yes No or P2 cursors as for progr stepl or P2 for program O A on k Om step Il and o Ja Change o o step Ill amm values We TE EN EI
50. to the BioShake even if the weight is radius and centripetal force F are too high then the shaking action Stops due to important values for efficient mixing excessive weight or excessive shaking frequencies As soon as you reduce the frequency the unit will stand firm Maximum shaker platform load 500 g filled well plate The shaker is driven by a maintenance free brushless motor which enables silent operation and constant shaking speed independent of the load IMPORTANT NOTES e Please start even with minimal mixing frequencies to avoid overloading e Only mix in sealed tubes and plates Sample material can be flung out of open inadequately sealed or unstable tubes and plates e When working with hazardous toxic and pathogenic samples always comply with the nationally specified safety environment e Pay particular attention to personal safety gear gloves clothing glasses etc the extraction hood and the safety class of the laboratory 18 Issue 06 2013 User manual BioShake series Specification 8 Specification 8 1 Adapter for microplates tubes and glass vials Analytik Jena Biometra offers high precision adapter plates to allow a perfect fit for all kinds of tubes vials microplates and other different disposables The adapter plates are optimized for an excellent heat transfer to the disposables and enhance the uniformity over all wells and the heat up or cool down time The exchange of adapter plat
51. tric electronic waste 13 Note for disposal of electric electronic waste This symbol the crossed out wheelie bin means that this product should be brought to the return systems and or separate systems available to end users according to yours country regulations when this product has reached the end of its lifetime For details please contact your local distributor This symbol applies only to the countries within the EEA EEA European Economics Area comprising all EU members plus Norway Iceland and Liechtenstein User manual BioShake series Issue 06 2013 27 EC Declaration of Conformity EU Konformitatserklarung 28 14 EC Declaration of Conformity EU Konformitatserklarung May 2011 im Sinne der EG Richtlinie ber elektrische Betriebsmittel zur Verwendung innerhalb bestimmter Spannungsgrenzen 2006 95 EG following the EC directive about electrical equipment for use within certain limits of voltage 2006 95 EC und and im Sinne der EG Richtlinie f r die elektromagnetische Vertraglichkeit 2004 108 EG following the EC directive about the electromagnetic compatibility 2004 108 EC Hiermit erkl ren wir dass folgende Shaker Herewith we declare that the following Shakers Typ type BioShake XP BioShake iQ Best Nr Order No 848 1808 0505 848 1808 0555 848 1808 0565 848 1808 0506 848 1808 0556 848 1808 0566 den grundlegenden Anforderungen der corresponds to the basic requirements of E
52. tting 1 min 99 h with automatic switch to stand by Working Alarm Continuous working audible alarm User manual BioShake series Issue 06 2013 19 Specification BioShake XP BioShake iQ Programming Operation control Micro controller Programs 2 programs definable buttons P1 and P2 Program capacity 3 steps internal memory Display Display 2 x 16 digits LCD display with backlight black Target values actual values Time mixing frequency temperature Electrical Operating voltages 24 V DC input 100 Watt Power supply External power supply unit 100 240 V AC 50 60 Hz Properties Housing material Aluminum anodized silver Operating range 5 C to 45 C 80 96 max relative humidity Dimensions WxDxH mm 142 x 170 x 80 Weight kl 27 Technical specifications are subject to change 20 Issue 06 2013 User manual BioShake series Ordering information 9 Ordering information Order No User manual BioShake series Product BioShake XP 100 240V EU plug without adapter plate BioShake XP 100 240 V US plug without adapter plate BioShake XP 100 240 V Japan plug without adapter plate BioShake iQ 100 240V EU plug without adapter plate BioShake iQ 100 240 V US plug without adapter plate BioShake iQ 100 240 V Japan plug without adapter plate ADAPTER for MICROPLATES Microplate adapter Flat bottom Microplate adapter flat bottom high base universal Microplate adapter 9
53. ty officer for details Use of radioactive substances Please contact your responsible person for details Use of genetically change organism or parts of those Please contact your responsible person for details Issue 06 2013 User manual BioShake series Note for disposal of electric electronic waste 13 Note for disposal of electric electronic waste This symbol the crossed out wheelie bin means that this product should be brought to the return systems and or separate systems available to end users according to yours country regulations when this product has reached the end of its lifetime For details please contact your local distributor This symbol applies only to the countries within the EEA EEA European Economics Area comprising all EU members plus Norway Iceland and Liechtenstein User manual BioShake series Issue 06 2013 27 EC Declaration of Conformity EU Konformitatserklarung 28 14 EC Declaration of Conformity EU Konformitatserklarung May 2011 im Sinne der EG Richtlinie ber elektrische Betriebsmittel zur Verwendung innerhalb bestimmter Spannungsgrenzen 2006 95 EG following the EC directive about electrical equipment for use within certain limits of voltage 2006 95 EC und and im Sinne der EG Richtlinie f r die elektromagnetische Vertraglichkeit 2004 108 EG following the EC directive about the electromagnetic compatibility 2004 108 EC Hiermit erkl ren wir dass folgende
54. use serious burns if touched Use extreme caution at all times Never leave your unit accessible to others when it is hot Never touch the plate surface unless you are sure it is cold Use oven gloves if necessary Do not unscrew any part of BioShake except for the interchangeable power supply the power cord and different blocks Do not make any mechanical or electrical modifications to the equipment Never do anything else with BioShake as intended in this manual Noncompliance of the safety instructions may lead to device damage loss of warranty and may cause serious personal injury as well as death General information User manual BioShake series Warning Injury from sample material being flung out Sample material can be flung out of open inadequately sealed or unstable wells plates and tubes e Only mix in sealed tubes and plates e When working with hazardous toxic and pathogenic samples always comply with nationally specified safety environment Pay particular attention to personal safety gear gloves clothing glasses etc the extraction hood and the safety class of the laboratory When setting mixing frequency adhere to the rules outlined in Fig 6 4 to 6 7 Issue 06 2013 7 Delivery parts 3 Delivery parts 3 1 BioShake iQ 1 BioShake iQ mM 2 Power supply 3 Power cord Operating manual no picture Fig 3 1 BioShake iQ 1 with power supply 2 and power cord 3 3 2 BioShake XP
55. with the technical specifications section 8 2 Use the normal care and precaution one would use with any electrical appliance Be sure to use a power cord with the same rating and of the same type three wire with neutral conductor as the one supplied with the instrument Ensure that voltage and frequency of your power source match the input voltage and frequency inscribed on the electrical rating label of the power supply AC DC adaptor and that the output voltage matches the rating of the equipment The AC DC adaptor is designed to work with a single phase power system having a grounded neutral conductor If you are not sure what type of power is supplied to your building contact your facilities manager As BioShake is an electrical device do not spill large quantities of liquid onto the device Do not use it in an explosive atmosphere As parts of the device may generate electric magnetic or electromagnetic fields keep parts away that may be affected e g data storage units Issue 06 2013 User manual BioShake series Safety instructions BioShake is capable of heating the plate surface up to 100 C This temperature is high enough to cause serious burns if touched Use extreme caution at all times Never leave your unit accessible to others when it is hot Never touch the plate surface unless you are sure it is cold Use oven gloves if necessary Do not unscrew any part of BioShake except for the interchangeable pow

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