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User`s Manual - Gray Matter Research
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1. Step 19 Loosen the set screw holding the guide rods in place then remove the guide rods Gray Matter Research Inc www graymatter research com Step 20 Remove the set screws that are used for holding the guide rods in place 23 Mounting microdrive insert assembly onto the recording chamber Figures 15 27 Figure 27 Step 21 Cover the assembly with the protective cap Gray Matter Research Inc www graymatter research com 24
2. Slowly advance the microdrive using the coarse manipulator Gray Matter Research Inc www graymatter research com 19 Mounting microdrive insert assembly onto the recording chamber Figures 15 27 Figure 23 eo ri LA A r NN vw Saa R ie vTT Tt vv aes Maas MALLS ERPS a ROE WU aaa rrit trrrey PON ENNEN h i N r lt lt lt Sn a OebERbRaneaas OY OO PAA Step 13 Mount the cap screws into the plungerblock that are used to Step 14 Tighten the cap screws into the plungerblock fasten the plungerblock to the chamber 20 Gray Matter Research Inc www graymatter research com Mounting microdrive insert assembly onto the recording chamber Figures 15 27 Figure 24 l lt 2 lt lt lt L a 5 o gt gt 5 gt Step 15 Loosen the holder on the coarse manipulator and begin to Step 16 Retract the coarse manipulator retract the coarse manipulator Gray Matter Research Inc www graymatter research com 21 Mounting microdrive insert assembly onto the recording chamber Figures 15 27 Figure 25 Step 17 Retract the coarse manipulator Step 18 Remove the coarse manipulator Gray Matter Research Inc www graymatter research com 22 Mounting microdrive insert assembly onto the recording chamber Figures 15 27 Figure 26 Be
3. Step 1 Once all electrode shuttle assemblies are loaded into Step 2 Mount the PCB onto the top surface of the the microdrive reorient the full assembly to a vertical plungerblock using the two 0 16 x 1 2 unm machine screws position Gray Matter Research Inc www graymatter research com Completion of microdrive assembly prior to mounting into chamber Figures 10 13 Figure 11 lead screw eweeeee sss reiri Ar t Peri theory TYI Step 3 Advance each lead screw through one of the holes in Step 4 Rotate the lead screw manually until it catches the the PCB until the screw rests on the shuttle threads of the shuttle Rotate the screw approximately 50 turns to raise the shuttle up the shaft of the lead screw Advance the lead screw into the microdrive Gray Matter Research Inc www graymatter research com 10 Completion of microdrive assembly prior to mounting into chamber Figures 10 13 Figure 12 compression spring gussesSseseecess Step 5 Advance lead screw until it seats flush against the Step 6 Mount a compression spring over the shaft of the top surface of the plungerblock lead screw Repeat steps 3 6 until all 32 screws and springs are loaded Gray Matter Research Inc www graymatter research com 1 Completion of microdrive assembly prior to mounting into chamber Figures 10 13 Figure 13 COLI gwessee sesei J Ag Step 7 Mount the screw guide over t
4. Mounting microdrive insert assembly onto the recording chamber Figures 15 27 Figure 19 Step 5 Tighten all of the cap screws onto the chamber using the Step 6 Mount the coarse manipulator onto the chamber round head hex wrench Gray Matter Research Inc www graymatter research com 16 Mounting microdrive insert assembly onto the recording chamber Figures 15 27 Figure 20 Step 7 Tighten the fastening ring onto the chamber and position the holder black over the microdrive Gray Matter Research Inc www graymatter research com Step 8 Advance the coarse manipulator until the holder makes flush contact with the top of the microdrive Then tighten the holder 17 Mounting microdrive insert assembly onto the recording chamber Figures 15 27 Figure 21 Step 9 Loosen the set screws at the top of the guide rods Step 10 Slowly advance the microdrive using the coarse manipulator Gray Matter Research Inc www graymatter research com 18 Mounting microdrive insert assembly onto the recording chamber Figures 15 27 Figure 22 AN Aen r SOR sy La 2 lt lt lt Er bc gt i lt a os banaan aa nue COP aE CECO AAAA r e s NENENN MALES 6a a D a A AN N S N lt lt lt E gt Eas Step 11 Slowly advance the microdrive using the coarse manipulator Step 12
5. The design drawing shown in figure 4 illustrates the arrangements between the actuator components and the body of the microdrive When assembled the lead screw passes through the PCB and the lower unthreaded portion of the screw fits into a blind hole in the bottom component of the actuator block This configuration stabilizes the vertical alignment of the screw The flange on the lead screw makes contact with the l Electrode top conductive surface on the PCB and the compression spring applies a constant downward pressure on the flange to insure that stable contact between the screw and the PCB 1S maintained when the screw guide is mounted pi gure 4 Cross sectional view of the design Electrical connection is mediated by contact from the electrode to the shuttle drawing of the microdrive actuator illustrating the to the lead screw to the PCB to the PCB connector relationships among the components Actuator Block Top AUS e ALALILA IL LADULLA ALLEELE Actuator Block Bottom Figure 5 Correct use of the precision screwdriver The screwdriver used to the control the actuator is very delicate and must be used with care and proper alignment A B These design drawings depict the correct alignment between the screwdriver blade and the lead screw C When the two parts are misaligned the screwdriver blade will rest on the top surface of the lead screw In this position a small gap will be apparent between the screwdriver and the to
6. The Deep Vertical Microdrive SC32 1DV assembly and loading instructions Coarse manipulator Headpost Connecting Rod gt LL j danaa a ag a ea Microdrive Insert assembly Headpost Adadi JL Cranial rapid prototype Figure 1 The Deep Vertical Microdrive SC32 1DV mounted onto a vertical recording chamber and rapid prototype of a monkey s skull Gray Matter Research Inc www graymatter research com The Deep Vertical Microdrive SC32 1DV enables the implantation and independent manipulation of 32 microelectrodes at depths greater than 20 mm To accomplish this the microdrive is coupled to a coarse manipulator system that allows all of the electrodes to be slowly advanced into the brain in one step This procedure places the tips of the electrodes at the starting position lying above the intended target structure Once this is completed the coarse manipulator is removed and the microdrive is fixed in place Following this procedure the electrodes can be advanced independently at the user s discretion using the precision control provided by the microdrive The electrodes are intended to remain in the brain for prolonged periods and small changes in electrode position can be used to record new activity When not in use the system is covered by a protective Titanium cap The following pages illustrate the sequence of steps for assembly of the system and the loading of the electrodes The adjacent photo
7. e sealant Figure 15 Sealing the bottom surface of the microdrive insert with silicone sealant Gray Matter Research Inc www graymatter research com Mounting of vertical chamber to rapid prototype of skull Figure 16 This figure illustrates the mounting of the vertical chamber onto a plastic model rapid prototype of a monkey s skull Step 1 Perform craniotomy and mount bone Step 2 Position chamber and insert within Step 3 Fix chamber to skull using acrylic bone screws around perimeter craniotomy cement Gray Matter Research Inc www graymatter research com 13 Mounting microdrive insert assembly onto the recording chamber Figures 17 27 Figure 17 Step 1 Position skull model so that the chamber is vertically oriented Gray Matter Research Inc www graymatter research com Step 2 Mount O ring red within the groove on the top surface of the chamber 14 Mounting microdrive insert assembly onto the recording chamber Figures 15 27 Figure 18 Step 3 Mount the plungerblock insert assembly onto the chamber using the pin on the top of the chamber as a guide Gray Matter Research Inc www graymatter research com Step 4 Mount the cap screws into the holes on the top surface of the insert Use care during this step to avoid dropping the screws into the insert If this occurs it may be necessary to remove the assembly from the chamber to retrieve the screw s 15
8. es in the plungerblock and chamber insert Be sure that the bottom surface of the guide rod does not extend beyond the bottom surface of the insert flange Gently tighten 2 56 set screw 4 Step 4 Retract plungerblock to top position of the guide rods then gently tighten set screws Be sure that the top surface of the guide rods are flush with the top surface of the plungerblock Figure 3 Steps for assembling the microdrive onto the chamber insert and guide rods Gray Matter Research Inc www graymatter research com Assembly and loading of the SC32 microdrive The SC32 1 utilizes a screw driven mechanism to bi directionally control electrode position along a single axis Fig 4 Each actuator consists of a lead screw an eccentric brass shuttle and a compression spring The uninsulated i Lead Screw end of each electrode is bonded to a shuttle using a conductive epoxy and the Screw Guide electrode shuttle assembly is loaded into the microdrive using a multistep Compression i sequence Fig 6 next page Spring When the device is assembled electrode position is controlled by rotation of the lead screw Fig 5 which causes the shuttle and the electrode to which it is bonded to translate Counter clockwise rotation of the lead screw causes the electrode to advance and clockwise rotation causes the electrode to retract Eccentric The movement resolution is 8 turns mm or 125 um for each full 360 rotation Shuttle of the screw
9. graph Fig 1 shows a fully assembled system mounted onto a plastic model of a monkey s skull rapid prototype reconstructed from an MRI scan that is held in place with a head holder system This illustrates the system as it would appear just prior to lowering all of the electrodes into the brain using the coarse manipulator Microdrive and Coarse Manipulator Parts i haaasddt E EE EEEE EE EEE beghes Figure 2 Components of the SC32 1DV microdrive system Actuator components are not shown Gray Matter Research Inc www graymatter research com 1 1 16 x 2 56 set screw 2 Guide Rod 3 1 4 x 1 2 unm machine screw 4 0 16 x 1 2 unm machine screw 5 0 12 x 0 8 unm machine screw 6 Printed Circuit Board 7 Plungerblock Bottom 8 Chamber Insert 9 Plungerblock Top 10 Screw Guide 11 Coarse Actuator 12 Coarse Clamp 13 Thumb Wheel 14 Fastening Ring Assembly of plungerblock chamber insert and guide rods plungerblock insert Step 1 Mount plungerblock assembly i e top and bottom plungerblock components into the chamber insert Be sure that the actuator holes in the plungerblock assembly are aligned with those in the chamber insert 3 Step 3 Repeat step 2 until all 4 guide rods are mounted and the set screws are tight Mount remaining 4 set screws into the plungerblock but do not tighten these screws 2 56 set screw guide rod Step 2 Mount each guide rod through the alignment hol
10. he lead screws and Step 8 Fasten the screw guide tight against the PCB by compression springs Be sure that all screws and holes are incrementally tightening each screw in succession to avoid aligned any tilting of the screw guide Gray Matter Research Inc www graymatter research com 12 Sealing the microdrive to prevent fluid backflow Step 2 Place a small amount of silicone grease onto the bottom surface of the insert Step 1 Once electrode loading and assembly is complete rotate the holder so that the microdrive is upside down Step 4 Gently wipe off the excess silicone grease from the bottom surface of the insert Be sure to remove all grease from the sides of the insert as well Step 3 Gently press the silicone grease into the holes using a spatula Repeat this step multiple times until the majority of the grease has been pressed into the holes Figure 14 Filling of the guide holes in the insert with silicone grease Gray Matter Research Inc www graymatter research com 3 Sealing the microdrive to prevent fluid backflow Step 6 Apply a small amount of the silicone sealant to the bottom surface of the insert Step 5 Carefully remove all excess silicone grease from the bottom surface of the chamber insert Step 8 Allow the sealant to cure for 24 hours Step 7 Gently move the sealant around the bottom surface of the insert until the entire surface is covered with a uniform layer of th
11. ion an additional 0 5 mm This keeps the electrode tips retracted within the drive and protected Gray Matter Research Inc www graymatter research com Loading microelectrodes into the plungerblock insert assembly Figures 7 9 Step1 Mount plungerblock insert assembly into holder tighten holder then rotate to a horizontal plungerblock orientation 2 56 set screw insert guide rod Step 2 Backload PI tubing through each hole in the insert PI tube Figure 7 Gray Matter Research Inc www graymatter research com Loading microelectrodes into the plungerblock insert assembly Figures 7 9 Figure 8 Gray Matter Research Inc www graymatter research com Step 3 Thread PI tubing into corresponding hole in the plungerblock Step 4 Front load the electrode shuttle assembly into the PI tube electrode shuttle assembly Loading microelectrodes into the plungerblock insert assembly Figures 7 9 Step 5 Advance electrode shuttle assembly through PI tube until the top surface of the shuttle is flush with the top surface of the plungerblock not shown Step 6 Remove PI tubing from below the bottom of the chamber insert leaving electrode shuttle assembly in place Figure 9 Gray Matter Research Inc www graymatter research com Completion of microdrive assembly prior to mounting into chamber Figures 10 13 Figure 10 plungerblock shuttle 2 56 set screw insert
12. p surface of the screw guide Gray Matter Research Inc www graymatter research com Assembly and loading of the SC32 microdrive Figure 6 Design drawings of a mock actuator illustrating the sequence of steps for assembly and loading of the microdrive prior to implantation Operations 2 11 should be performed while the plungerblock is firmly mounted in the holder Step 1 Assemble the bottom and top components of the plungerblock Step 2 Insert the polyimide tubes from below into each hole of the plungerblock bottom until they are visible from the top surface Step 3 Front load each electrode into the polyimide tubes Step 4 Advance each shuttle into the plungerblock until it is flush with the top surface of the plungerblock Step 5 Mount the PCB on the plungerblock Step 6 Advance the lead screw through the PCB and catch the threads on the shuttle Rotate the lead screw to retract the shuttle onto the shaft of the screw Step 7 Advance the lead screw into the microdrive until the flange on the screw sits flush against the top surface of the PCB Step 8 Mount the compression spring onto the shank of the lead screw Step 9 Mount the screw guide over the exposed screws springs and tighten down to the PCB Step 10 Remove the polyimide tubes from the bottom of the drive Step 11 Retract each electrode by clockwise rotation of the lead screw Once the tip of the electrode is no longer visible continue retract
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