Pre-Installation Instruction
Contents
1. Specified electrical supply and power outlets are installed Installation Site Power In the United States the power supply to the installation site must be 100 120V ac and 200 240 V ac In Europe the power supply to the site must be 200 240V ac The power supply must be stable free of fluctuations due to slow changes in the average voltage or to changes resulting from surges sags or transients A measured ground to neutral potential of greater than 3 volts ac or dc indicates grounding problems that may need correction before connecting an instrument module to the power source Evaluate any power source suspected of having noise problems evaluated with a recording type power line monitor before operating the system NOTE If concerned about the quality of the power install an uninterrupted power supply or a power conditioner or both Table 10 has more information Table 10 Power Consumption MS Configuration Maximum Power Consumption 500 MS without foreline pumps 1200VA 500 MS with foreline pumps 3200VA Vv Check the checklist box Specified electrical supply and power outlets are installed 395407500 Rev 6 9of 13 Pre installation Instructions Qualified Computer Equipment If the Varian MS Workstation software is to be installed on a computer not purchased from Varian the customer is responsible to ensure that the computer is adequately equipped and compatible with the operation of the data system and its communica2. When the LC MS Arrives cccccccecseseeceeeseeeeeeaeees 12 Inspecting the Shipping Cartons ccceeee 12 Unpacking and Installation cccceeeeeseeeeeeeees 13 Spare PANS aeie E 13 Preventive Maintenance ccccseeceseeeceeeeaeeeeeeeeaes 13 The Pre installation Instructions are a guide for each requirement of the checklist Follow these instructions to ensure that the installation requires no more than the usual three days Have the completed checklist available to schedule the installation After the Varian Representative completes the installation and it is accepted samples can be analyzed After meeting all of these requirements contact the Customer Service office in your region to schedule installation The LC MS operates reliably under carefully controlled environmental conditions You must provide suitable power sources operating environment materials and solvents Failures may occur if you use or maintain the system outside of the power and operating environment ranges and limits described in these instructions The Varian Warranty and Service contract specifically excludes the repair of failures due to such causes All phases of the installation site preparation must conform to caution Safety local safety electrical and building codes These codes take precedence over any recommendations in these instructions Compliance is the responsibility of the customer Safety
3. 5 F during instrument operation NOTE As the installation site temperature increases system reliability decreases due to heat generated by electronic components during operation This heat must dissipate to the surrounding air for reliable operation The turbomolecular pumps have a temperature cutoff control that protects the bearings and prolongs the pump lifetime If the temperature rises above 30 C 86 F the pump may shut down Operating the MS at optimal temperatures prolongs the turbo pump lifetime 395407500 Rev 6 6 of 13 Pre installation Instructions The airflow around the system must be adequate The air conditioning system must maintain a constant temperature within operational limits around the system Do not place the system near air ducts windows or heating and cooling systems The average steady state heat load for the MS alone is 5200 Btu hr with a possible short term heat dissipation of 8900 Btu hr during startup Vv Check the checklist box Temperature maintained between 16 and 30 C 61 86 F Humidity The relative humidity of the operating environment must be between 20 and 80 with no condensation Operating the LC MS at a very low humidity may result in the accumulation and discharge of static electricity shortening the life of electronic components Operating the system at high humidity may produce condensation and result in short circuits Varian recommends using a combination temperature and h
4. ER IN TRANSIT e Blue beads in the Tip N Tell arrow point MAKE NOTE ON BILL OF LADING AND CHECK i FOR DAMAGE ANY CLAIMS FOR TIPPING One Tip N Tell indicator label is on the exterior of DEPEND ON THIS NOTATION each shipping carton Read and follow the instructions on the label If the Tip N Tell arrow S TIPE point is blue the carton was on its side or tipped in i TELL transit and instrument damage may have occurred k a PATENT NO 3 926 144 PRINTED IN LULS A If no external damage is apparent sign the receiving documents Received but not inspected to indicate that the cartons were not opened If the customer receives obviously damaged materials without noting the damage on the receiving documents Varian will not accept the liability Do not open any cartons The Varian Representative opens them during installation Move the shipping containers to a warm dry and secure area near the installation site If a shipping carton shows evidence of damage do the following damaged shipping carton procedure 1 Report the conditions to the carrier when you receive the shipment 2 Note the damage on all copies of the shipping documents 3 Write a brief description of the damage 4 Ask the driver to sign next to your comments to signify agreement with the observations 5 Contact the appropriate Varian office to report the damage Systems are shipped either FOB Varian or FOB Destination The manne
5. NOTICE Varian Inc was acquired by Agilent Technologies in May 2010 This document is provided Varian 500 MS Series LC MS as a courtesy but is no longer kept current and thus will contain historical references to Varian For more lon Trap Mass Spectrometer information go to P P re i nstal latio n nstru ctions ee Agilent Technologies Checklist NOTE Do not unpack the shipping cartons Check off each checklist box after satisfying each requirement as described in the instructions All requirements must be met before requesting installation NOTE If the installation site is not ready for installation when the Varian Representative arrives Varian Inc reserves the right to invoice for the Representative s time REQUIREMENTS Installation site is in compliance with all relevant safety regulations User Representative will be available during the installation and Varian certification period Entrance to the installation site is at least 92 cm 36 in wide Bench space is sufficient Bench can support system weight Bench does not vibrate Exhaust system is suitable Temperature maintained between 16 and 30 C 61 86 F Relative humidity maintained between 20 and 80 Installation site is free of excessive particulate matter Specified electrical supply and power outlets are installed Nitrogen gas at least 99 pure regulator and gas lines are installed Air less than 0 1 ppm hydrocarbons regulator and gas l
6. ch is on the MS Workstation CD has a list of spare parts for routine operation Preventive Maintenance The customer is responsible for performing routine and preventive maintenance of the LC autosampler MS and data system If using a nitrogen generator perform the preventive maintenance to ensure that the nitrogen supply is clean and dry Any instrument problems resulting from a contaminated gas supply are billable and not included in the Varian Warranty Perform regular preventive maintenance to increase the life of the system to maximize system uptime and optimize system performance Refer to the 500 MS lon Trap Mass Spectrometer Hardware Operation Manual for details The Varian Representative will describe and demonstrate these procedures during the installation Trademark Acknowledgment Microsoft and Windows are registered trademarks of Microsoft Corporation Swagelok is a registered trademark of Swagelok Company Solon Ohio PEEK is a registered trademark of the Victrex PLC Company Lancashire England Other brand and product names are trademarks or registered trademarks of their respective holders 395407500 Rev 6 13 of 13 Pre installation Instructions
7. cropipette capable of dispensing 200 uL and tips Table 12 Solvents for ESI and APCI Solvents for ESI and APCI Quantity Solvent each 4 liter bottles LC MS grade water new and unopened 4 liter bottles LC MS grade methanol new and unopened 4 liter bottles LC MS grade acetonitrile new and unopened Additional tubing is required to complete the installation Most of this tubing is included in the accessory kits of the LC modules Additional tubing PEEK or stainless steel may be required for installation of special valves or modules For most analytical HPLC systems use 1 16 in tubing with an ID of 0 005 in Use 0 005 in ID or smaller tubing downstream of the sample injector and autosampler to prevent peak broadening Keep the tubing as short as possible to prevent peak broadening and to minimize run time Vv Check the checklist box Materials and solvents of specified grade are on site 395407500 Rev 6 11 of 13 Pre installation Instructions When the LC MS Arrives Inspecting the Shipping Cartons After the LC MS arrives carefully inspect the exterior of the shipping cartons for evidence of any damage that might have occurred during shipment KEEP Inspect the cartons for the following UPRIGHT e Water stains e Cuts punctures or deep indentations MONITORED SHIPMENT e Crushed corners or excessively abraded IF TIP N TELL ARROW POINT IS BLUE THIS edges PACKAGE HAS BEEN ON ITS SIDE OR TIPPED f f OV
8. ines are installed Helium 99 999 pure regulator and gas lines are installed Materials and solvents of specified grade are on site Shipping cartons examined for damage If there was any damage the damaged shipping carton procedure was completed Requesting Installation After preparing your site contact the Customer Service office in your region to schedule installation 395407500 Rev 6 10f 13 Pre installation Instructions Contents HFUMFOCUGU ON anin E AN A SeN ornina a Before the Installation ccccccccsecesseeeecseeesseeeesaeees User Representative cccccccsccsseeceseeceeeeeeeeseees PLP A CO AAEE E cta te panera tenes A TEES Bench Space and Load ccceccceeceeeeseeeeaeeeseees MAD FAN Oae aa a eater tons a tata late Foreline S PUMPS ccccseseeccsseeecceeeeeeseeseessaees Exhaust Sy SOM sci ch shic batacc a Vemper ratura che nacscrtat an aera ce eect GIAL I S one eee ae Om mn ne snare E ee EA E E Ser Particulate Matter eiveses sence dad dvea inant a Introduction Power Requirement c ccsscccseecseeceeeeeeeeseeeeees T Installation Site POWeTf oannnannnannnennnnnnnnnnnnnnnnnnne 9 Qualified Computer Equipment c0cccceeees 10 Gas Requirements cccccceeeceeeeeceeeeseeeeesaeeeees 10 Materials and Solvents ccccccececseeeeeeeeeeeeseees 11 When the LC MS Arrives ccccsccecseeeeceeeeseeeeesaeees 12
9. is the most important consideration for instrument use Determine if the installation site complies with all relevant safety regulations Check the checklist box Installation site is in compliance with all relevant safety regulations 395407500 Rev 6 2 of 13 Pre installation Instructions Before the Installation User Representative Schedule the installation when the User Representative will be available One of the important duties of the Varian Representative is to familiarize the User Representative with the basic functions of the LC MS Check the checklist box User Representative will be available during the installation and Varian certification period Entrance Before arranging for delivery of the LC MS determine that there is sufficient clearance to move the shipping cartons to the installation site The largest shipping carton is 72 cm 28 in wide by 92 cm 36 in long If the cartons are to be moved with the pallet at least 92 cm 36 in clearance is needed Allow additional room for maneuvering the shipping containers around corners or through doors Vv Check the checklist box Entrance to the installation site is at least 92 cm 36 in The MS foreline pump s and LC are heavy To prevent Kc AUTION personal injury use appropriate moving and lifting techniques Bench Space and Load Use the following information to plan the layout of the modules of your LC MS system The Varian Representative will
10. oor below the LC MS not a on the bench with the LC MS Vv Check the checklist box Bench does not vibrate 395407500 Rev 6 5 of 13 Pre installation Instructions Foreline s Pumps The following table has general information about the foreline pump s Table 6 Foreline Pump Information Weight or Load for optional 72 kg or 160 Ib foreline pump bench Diameter of hole in wall if 2 each 5 8 cm 2 3 in needed Width 35 6 cm 14 in Depth 52 1 cm 20 5 in Height 48 3 cm 19 in Vacuum line length 2 each 1 8 m 6 ft Power cord length 2 0 m 6 ft and 7 in Dedicated circuits 1 for each pump Power 10A 200 240V ac Power cord plug CEE 7 7 or NEMA 6 15P Exhaust System Do not put the foreline pump s in an enclosed space Foreline pumps exhaust most compounds introduced into the MS and small amounts of oil vapor Serial cable length 2 7 m 9 ft Provide an adequate fume exhaust system for the outlet of each foreline vacuum pump Each foreline pump must be vented at least 2 L min The API spray chamber must be vented at least 12 L min to a separate vent line Ensure that the exhaust system does not pull a vacuum on the API chamber Consult local regulations for the proper method of exhausting the fumes Tl Check the checklist box Exhaust system is suitable Temperature The optimal operating range is between 16 and 30 C 61 86 F for best mass stability the temperature should not vary by more than 3 C
11. or and gas lines are installed Air A compressed air gas supply capable of providing up to 2 L min of gas regulated to 80 psi with a two stage regulator is required as a nebulizing gas for negative ESI The customer is responsible to conform to all regulations for the installation and operation of the gas system The air must be clean and dry with less than 0 1 ppm total hydrocarbons including methane and have a 40 C dew point The air supply uses in connectors Check the checklist box Air less than 0 1 ppm hydrocarbons regulator and gas lines are installed Helium Use helium as the ion trap damping gas with a flow rate of 1 mL min Helium must be at least 99 999 pure and regulated to 40 psi 2750 bar The minimum requirement is one 257 ft tank with an Alltech regulator AL8111 or equivalent tank and regulator If you are concerned about the cleanliness of the helium use a Gas Clean filter Varian Part Number CP17973 Vv Check the checklist box Helium at least 99 999 pure regulator and gas lines are installed 395407500 Rev 6 10 of 13 Pre installation Instructions Materials and Solvents The Varian Representative prepares solutions to tune and evaluate the LC MS Please supply the materials on Table 11 and the solvents on Table 12 Table 11 Materials Quantity each 100 mL clean and new volumetric flasks 10 mL clean and new volumetric flasks Micropipette capable of dispensing 1 0 mL and tips Mi
12. plugs Computer 1 each 110V US 1 each NEMA 5 15P 1 each 220V US 1 each NEMA 6 16P EU 1 each CEE 7 7 plugs LC modules 110V or 220V see appropriate user manual Use a separate dedicated power source for the HPLC modules additional instruments and equipment Never plug the mass spectrometer and the chromatograph into the same power source or the power source may overload Never use the free outlet on any of the power sources for equipment that draws more than 2A Table 8 has the power requirements for the modules of the LC MS Table 8 LC MS Power Requirements Max Current Draw Amps 200 240V ac System Foreline Pump 5 per pump Power Cables Table 9 has information about the power cords and plugs Figure 2 shows the plug types Table 9 MS and Foreline Pump s Power Cords 1 each 2 5 m 8 ft 2 each 2 0 m 6 ft 7 in Power Plug 1 each CEE 7 7 plugs 2 each CEE 7 7 plugs The power cables for the CPU monitor and printer are approximately 2 13 m 7 ft long They have NEMA 5 15P plugs Replacing or substituting power cords or plugs must be done with strict compliance with all regulations including CAUTION electrical codes power cord color coding and appropriate regulatory agency certification marks 395407500 Rev 6 8 of 13 Pre installation Instructions Outlets Plugs f Y o j CEE 7 7 NEMA 6 15P d NEMA 5 15P Figure 2 CEE 7 7 NEMA 6 15P NEMA 5 15P Outlets and Power Plugs Vv Check the checklist box
13. r of shipment determines who is responsible for filing a claim against the carrier if the system was damaged in transit Most systems are shipped FOB Varian so the purchaser and the carrier are responsible for any damages incurred during shipping Contact the Varian office for assistance with filing claims and billing repairs If the system is shipped FOB Destination contact the Varian office and that office files a claim against the carrier Check the checklist box Shipping cartons examined for damage If there was any damage the damaged shipping carton procedure was completed 395407500 Rev 6 12 of 13 Pre installation Instructions Unpacking and Installation The Varian Representative will review the Pre installation Checklist with the customer to ensure that the site requirements were met The Varian Representative will unpack and install the instrument and demonstrate the fundamental operation and maintenance procedures The User Representative must be present during the installation The Varian Representative will demonstrate that the system meets the performance specifications which are on the data sheet and any additional criteria explicitly written into the sales contract Plan to analyze samples only after the installation is complete and the conditions of delivery are accepted The process requires at least three days Spare Parts The 500 MS lon Trap Mass Spectrometer Hardware Operation Manual part number 395407600 whi
14. r to the Varian LC Systems Pre installation Instructions part number 391483100 for information about LC modules Plan to put the monitor and keyboard on the same bench as the LC MS If the plan is to use a separate bench position them within 3 m 10 ft of the rear of the LC MS The CPU can go on or under the bench 395407500 Rev 6 4of 13 Pre installation Instructions Table 3 Additional Bench Space Requirements Provide space for air circulation gas lines and electrical 15 to 30 cm 6 to 12 in behind the system connections Dissipate room heat and allow for At least 76 cm 30 in above the above the routine maintenance system Analytical Systems only Provide space for solvent bottles At least 30 cm 12 in to the side of the LC Decide how to arrange the modules Use Table 4 and Table 5 to determine the width of the bench and the load the bench must support Regardless of modules the bench must be at least 84 cm 33 in deep to accommodate the MS Table 4 Bench Width Worksheet Bench LC Auto Other Modules CPU Monitor and Total Length sampler Keyboard x es ene fen Monitor CPU and Vv Check the checklist box Bench space is sufficient Vv Check the checklist box Bench can support system weight Vibration Ensure that the benches are free from vibrations especially those caused by equipment in adjoining locations Because the foreline pump s vibrates during operation it belongs on the fl
15. tion interfaces Please check the current list of requirements available at the following web site http www varianinc com cgi bin nav products chrom qcms msws computer req Varian does not guarantee the function of the Varian MS Workstation software on computer hardware or operating systems that do not meet the specified requirements NOTE Contact your Sales Representative for a list of qualified equipment or for more information Gas Requirements Nitrogen A nitrogen gas supply that can provide up to a maximum of 12 L min of gas regulated at 80 psi is sufficient for ESI or APCI operation for one LC MS If there is more than one LC MS use a nitrogen supply that can deliver a maximum of 18 L min The nitrogen must be at least 99 pure with less than 0 1 ppm hydrocarbons and less than 1 oxygen It must be clean and dry with a 40 C dew point Use a nitrogen generator or a liquid nitrogen boil off to supply the nitrogen gas All nitrogen generators require regular maintenance The customer is responsible for setting up the preventive maintenance procedures and schedules contact the nitrogen generator manufacturer Any MS problems caused by poor gas quality are not covered by the Varian Warranty It is the responsibility of the customer to conform to all regulations regarding the installation and operation of the gas system The nitrogen supply uses 1 4 in connectors Check the checklist box Nitrogen gas at least 99 pure regulat
16. umidity monitor in your installation site Vv Check the checklist box Relative humidity maintained between 20 and 80 Particulate Matter The installation site must not have excessive dust smoke or other particulate matter Particulate matter may block airflow vents and cause the electronics to overheat Vv Check the checklist box Installation site is free of excessive particulate matter Power Requirements 212 LC Power Input 85 264V ac 47 63 Hz 60 Watts 100VA 216 LC 115V ac 15 20 50 60 Hz 250VA 230V ac 15 20 50 60 Hz 250VA For UPS assume 250W For 115V ac one 5 0 AT fuse 5 x 20 mm IEC 127 For 230V ac one 2 5 AT fuse All fuses supplied with the 216 LC instrument are UL listed and CSA certified The 216 LC must be used with appliances and power sources that have the proper protective grounding 500 MS The 500 MS requires a separate circuit and the outlet must have adequate amperage capacity and a reliable ground The power source must be clean and provide 220 240V ac 50 60 Hz 3 Hz 1 0 kW 3200 VA steady state 395407500 Rev 6 7 of 13 Pre installation Instructions 500 MS LC MS The 500 MS LC MS has the circuits power plug and outlet types listed onTable 7 Table 7 500 MS LC MS Circuit Power Plug and Outlet Types Component Power Plug and Outlet type MS 1 each 220V US 1 each NEMA 6 15P EU 1 each CEE 7 7 plugs Foreline Pump 2 each 220V US 1 each NEMA 6 15P EU 1 each CEE 7 7
17. unpack the cartons and puts the modules on the bench shows a suggested layout for the LC MS 395407500 Rev 6 3 of 13 Pre installation Instructions 500 MS with 212 LC and ProStar 430 Figure 1 shows a possible layout for the LC MS with the 212 LC pumps and the ProStar 430 AutoSampler Modify this layout if you have the ProStar 220 pumps The autosampler belongs on the side of the 212 LC pumps not on top The bench must be strong enough to support the weight of all modules wide enough for all modules and at least 84 cm 33 in deep for the MS NOTE Do not stack an autosampler on top of the 212 LC pumps Pl il o Figure 1 Typical Layout Table 1and Table 2 list the dimensions and weights of the modules in Figure 1 ProSta 26 e mam Table 1 Bench Space ProStar 430 212 LC Total Determining Space and Load The system requires a clean flat bench The bench must have enough space for modules the mouse solvent bottles and such see Table 3 The bench must be strong enough to support the weight of the modules If the bench is against a wall drill a hole large enough for the vacuum tubing of your pump s through the rear of the bench The area under the bench must be large enough for the height of the foreline pump s see Table 6 If the bench is higher than 92 cm 36 in place a vibration isolation bench under the pump s The vibration isolation bench must be capable of supporting the pump s Refe
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