PRECELLYS® Evolution SAMPLE PREPARATION & CELL LYSIS
Contents
1. Precellys Evolution has been designed to operate at a maximum speed of 10 000 rpm rotations per minute Technical specifications A Precellys Evolution lysing protocol is composed of several successive Power supply 230 V 50 Hz EU standard cycles between which the lid must not be opened 110 V 60 Hz US standard Speed and other parameters can be adjusted via the control panel Consumption lt 1 kVA Fuse 5x20 T 1OA H 250 V Safety information Class A apparatus Protocol parameters Values Physical specifications Tube capacities 2mL 7 mL or 15 mL Width 380 mm Speed from 4 500 to 6 800 rpm and from 7 200 to 10 000 Length 520 mm rpm in increments of 100 rpm Height 400 mm 635mm with lid open Number of cycles from 1 to 10 Weight lt 30 kg l Operating temperature 15 30 C E o from 10 to 900 seconds in increments of 1 second Humidity 15 85 RH Waiting time between 2 cycles from 1 to 120 seconds in increments of 1 second Altitude lt 2000 m Operating specifications Programming of speeds between 6900rpm and 7100rpm is not permitted in order Speed range 4500 10 000 rpm to ensure good working order and maximum product life Number of cycles 1 l0 Cycle duration 10 900 seconds l l l l Waiting time between 2 cycles 1 120 seconds The operator is responsible for programming the unit For each speed a Precellys E2. 1 Remove the indented plate 2 Position the tubes in the tube 3 Put the indented plate back holder 2 7 ou 15mL in place 5 2 4 Closing the lid Lower the lid until the locking handle clicks into place 5 2 5 Lysing protocol procedure After confirming the launch of a lysing protocol by pressing the Start NB button the system creates a vacuum below the indented plate Time and speed settings cannot Once the tubes are correctly held in place i e sufficient vacuum the be changed while a protocol Is in protocol will begin and the green light will flash progress A timer counts down the remaining time in minutes and seconds until the end of the protocol Page 17 bertin TECHNOLOGIES PRECELLYS Evolution INSTRUCTIONS n Ensure that the system has stopped completely before opening the lid WARNING dk To prevent the equipment from overheating a rest period of 2 to 5 minutes between two lysing protocols is strongly recommended A WARNING N Use of lysing kits beyond their use by date may result in sudden damage to tubes bertin Page 18 TECHNOLOGIES USER MANUAL 5 2 6 End of a lysing protocol At the end of a lysing protocol the system returns to the Start menu The vacuum created beneath the indented plate will be released a few seconds after the system has shut down the indented plate cannot be removed during this short per
3. BP 284 78053 Saint Quentin en Yvelines Cedex France Tel 33 0 1 39 30 61 60 Mail info precellys com 1 5 Technical support In the event that you are unable to find a solution to any technical issues despite the information contained in this manual please contact your nearest distributor 2 Description of PRECELLYS Evolution 2 1 Product overview This warranty is limited to a period of one 1 year and does not apply to the following parts fuses toric joints containment seals indented plate and tube holder This warranty is valid from the date of the installed equipments online registration via the www precellys com web site J warranty is not applicable in the following circumstances The equipment has not been installed operated or maintained in compliance with the instructions described in this user manual e The equipment has been repaired or modified by unauthorized personnel e The equipment serial number has been damaged or removed Precellys Evolution has been designed for lysing and homogenising biological samples contained in glass tubes at variable speeds for the extraction of proteins nucleic acids drugs etc The equipment can simultaneously agitate at high speed tubes containing several millilitres of sample full range of tube sizes available at www precellys com Precellys Evolution offers the following key advantages e Easy tube loading an innovative system automatically
4. and signature www precellys com Phone 33 0 139 306 160 b t l info precellys com J Fax 33 0 139 306 185 g m mn TECHNOLOGIES u Page 25 bertin TECHNOLOGIES PRECELLYS Evolution USER MANUAL Notes bertin Page 26 Page 27 bertin Precellys The Science of Lysing www precellys com More than 1000 scientific protocols and data on the application center Join the Precellys community now m 7 COPYRIGHT BERTIN TECHNOLOGIES Tel 33 0 1 39 30 61 60 Design graphique www idsg fr
5. blocks the lysing tubes during operation e Easy decontamination zones which have to be decontaminated are easily accessible e Flexible and easy cycle programming cycle speed e No alteration of the biological samples and no cross contamination e _ Efficient and homogeneous lysis in all tubes whatever their capacity Page 7 bertin TECHNOLOGIES PRECELLYS Evolution USER MANUAL DESCRIPTION DESCRIPTION Precellys Evolution in pictures 2 2 Tube motion a Thanks to the equipment s design and symmetry every tube of the same size strictly follows the same motion to ensure the same level of lysis and homogenization for each sample The centre of gravity of the tubes follows a tri dimensional path on a sphere s surface While the mixture contained in the tubes moves in all directions it moves primarily in the vertical axis to allow for efficient homogenization The movement generated by Precellys Evolution is known as precession movement i e tubes are not rotated The tubes must be compatible with the holder and must be capable of withstanding 600 G of linear acceleration during 5 minutes without suffering any deformation see usage recommendations at 1 1 1 The precession movement during biological sample homogenization causes the temperature of the samples and the equipment to rise Lid Locking handle Programming and control panel Indented plate Tube
6. holder Metallic support ring Containment seal ovr amp N K i 8 Air intake vent 9 USB socket 10 Maintenance sockets 11 On Off button 12 Power supply socket 13 Fuse The USB connection allows only the connection of data storage media USB key bertin Pages Page 9 bertin TECHNOLOGIES TECHNOLOGIES PRECELLYS Evolution DESCRIPTION bertin Page 10 TECHNOLOGIES USER MANUAL 2 3 Control panel DESCRIPTION 2 4 MMI menus The screen immediately lights up when Precellys Evolution is switched on and displays the main menu after a few seconds once the system has booted up 0 Preceallys Evolution start stop a 000 A few seconds after switching on the equipment the main menu will be displayed enabling access to the different menus of the menu tree described below Main menu Sub menus or Description possible actions Start Choose a pre set Press the Left Right buttons to select from the sliding bar at protocol the bottom of the screen Adjust a protocol setting solely in Work mode 1 Navigate in the screen using the Up Down buttons 2 Select the setting to adjust by pressing the OK button 3 Adjust the value of the setting using the Up Down buttons 4 Validate the new value by pressing the OK button Launch
7. GZ lys The Science of Lysing USER MANUAL MANUEL UTILISATEUR PRECELLYS Evolution SUPER Homogenizer SAMPLE PREPARATION amp CELL LYSIS TECHNOLOGIES PRECELLYS Evolution USER MANUAL Produced by BERTIN TECHNOLOGIES Parc d activit s du Pas du Lac 10 bis avenue Amp re BP 284 78053 Saint Quentin en Yvelines Cedex France Phone 33 0 1 39 30 61 60 Email info precellys com Reference 002520 800 DU003 B bertin Page 2 TECHNOLOGIES SOMMAIRE 1 INTRODUCTION 1 1 Safety instructions and recommendations 1 2 Warranty 1 3 Equipment references 1 4 Manufacturer s address 1 5 Technical support 2 DESCRIPTION OF PRECELLYS EVOLUTION 2 1 Product overview 2 2 Tube motion 2 32 Control panel 2 4 MMI menus 2 5 Programming 2 6 Equipment specifications 2 TRANSPORT AND STORAGE 3 1 Transport 3 2 Storage INSTALLATION 4 1 Unpacking 4 2 Installation and connection to power supply 5 INSTRUCTIONS FOR USE 9 1 Preparing samples 5 2 Launching a lysing protocol Dg Lysing kit use by dates 6 ALARM MESSAGES A MAINTENANCE 7 1 Troubleshooting guide 72 Replacement of spare parts 8 CLEANING amp DECONTAMINATION 8 1 Recommendations 8 2 Example decontamination procedure 9 REPAIR AND DISPOSAL 9 1 Repair 9 2 Disposal L0 ANNEX 1 Page 3 bertin TECHNOLOGIES PRECELLYS Evolution INTRODUCTION This user manual includes all necessary informa
8. Is free of defects at the time of shipment bertin Page 6 TECHNOLOGIES Ne pas ouvrir le capot lors du fonctionnement Do not open the cover while running USER MANUAL 1 1 6 Safety warning symbol The symbol illustrated below may be found on different parts of the unit Users must comply with all instructions associated with this symbol This equipment may only be repaired by persons authorized to do so by the manufacturer or the distributor 1 1 7 Noise level When operating at maximum speed i e 10 000 rpm the noise level of the apparatus does not exceed 70 dBa 1 1 8 Electromagnetic interference WARNING This is a Class A apparatus This equipment may therefore cause radio electric interference in a residential environment In such cases users should take appropriate measures 1 1 9 Intensive use lf this device is used in an intensive manner high speed long cycle duration fully loaded with 24 tubes high number of cycles the temperature of the system will increase The increased temperature level may trigger the thermal security protection system In this case the electrical power input of the motor will cut off automatically to prevent the equipment from overheating 1 2 Warranty DESCRIPTION 1 3 Equipment references Serial number PRECELLYS EQ02520 300 RDO00 0 1 4 Manufacturer s address BERTIN TECHNOLOGIES Parc d activit s du Pas du Lac 10 bis avenue Amp re
9. a lysing protocol Press the Start button When the protocol has ended press the Stop button to go back to the previous menu System settings Choose language Change the language of the MMI by pressing the OK button Set date Adjust the date and time by pressing on the OK button and then using the Up Down and Left Right buttons Protocol Create Create a new protocol that will then be displayed in the management sliding program bar see Choose a pre set protocol Edit Modify a pre set protocol Delete Delete a pre set protocol see Choose a pre set protocol Move Change the position of programs in the sliding program bar see Choose a pre set protocol NB the position of the Work program cannot be changed Data Save all programs Transfer all protocols recorded in the Precellys Evolution management to USB unit to an external data storage source USB Load all programs Transfer all protocols from an external data storage source from USB to the Precellys Evolution unit WARNING this action will delete all protocols currently registered in the unit Save file history to USB Back up the equipment s file history protocols launched alerts date changes Update equipment from USB Upload a new version of the MMI software Page 11 Dbertin TECHNOLOGIES PRECELLYS Evolution USER MANUAL DESCRIPTION DESCRIPTION 2 5 Programming 2 6 Equipment specifications
10. containment seal is indeed a key element in ensuring the containment of all electrical parts of the equipment and protecting them against accidental liquid 4 1 Unpacking 1 Check the contents of the box in order to ensure that all of the following items are present 1 user manual French English 1 Precellys Evolution including one 2ml indented plate one 2ml tube holder one toric joint and one containment seal 1 power cable 1 spare toric joint 1 spare fuse 1 QC report 1 EC certificate of conformity 1 manufacturer s inspection certificate In the event that any of these items are missing please contact your local distributor immediately A plug adapter or compatible power cable not included will be required for countries other than the following Europe United Kingdom USA Switzerland and Australia 2 Carefully remove Precellys Evolution weight 27 2 kg from its box and place it on a clean flat and stable work surface the 4 feet are height adjustable to ensure optimum stability of the equipment 3 Inspect the equipment carefully and report any damage to the carrier immediately 4 Keep the box the protective foam and the documentation in a safe place all will be required in the event that the equipment needs to be returned SP MES J 2 Position the toric joint in place see 7 2 1 3 Check the coherence of the technical specifications provided in this user
11. e fuse can easily be replaced by the user with the aid of a flat blade screwdriver see 7 2 3 1 1 5 Biological risks Gloves must always be worn when handling samples and all safety instructions related to bio hazardous agents complied with in order to prevent any risk of contamination rn Although this equipment is fully insulated and earthed it is important for all users to be aware of the potential hazard of using liquid close to a power Supply If any liquids are spilled disconnect immediately the equipment from the main power supply remove the power cord from the AC power input on the rear panel and clean the equipment and the surrounding area Waste produced by the normal operation of this equipment must be placed in biological A sticker bearing the Biological risk symbol is aata Pon Si nere ard romoved Supplied with the equipment and must be placed on and disposed of by specialized the front side of the unit when used with samples of a KWE ia L N ae companies potentially infectious nature un Do not reconnect the equipment until it has been fully inspected Under no circumstances should the cover be withdrawn by the operator risk of electric shock bertin Page 4 Page 5 bertin TECHNOLOGIES TECHNOLOGIES PRECELLYS Evolution INTRODUCTION a an d WARNING gt Sk Bertin Technologies hereby certifies that this product
12. er set the unit at an angle Precellys Evolution must always be Power cut For safety purposes the indented plate is used when evenly balanced on its 4 feet Failure to comply with this held down by vacuum pressure instruction may result in damage to the internal components or in Reconnect the power supply in order to remove the indented plate bertin Page 20 TECHNOLOGIES PER of the plastic casing J Page 21 bertin TECHNOLOGIES PRECELLYS Evolution USER MANUAL MAINTENANCE MAINTENANCE CLEANING 7 2 1 Replacing the toric joint 7 2 3 Replacing the fuse The toric joint located on the metallic support ring can show signs of wear A flat blade screwdriver is required for changing the fuse over time It is strongly recommended to replace the toric joint whenever the Pressure Alarm message Is displayed permanently As an additional precaution the joint should be changed at least every six months A WARNING Switch off the equipment and Flat blade screwdriver disconnect from the mains power supply before performing this operation Fuse 7 2 2 Replacing the containment seal The containment seal should be replaced at least once a year This procedure does not require the dismantling of the metallic support ring 1 Place the interior part of the containment seal against the i ER metallic ring 8 Cleaning amp Decontamination 2 Place the exterior part of the containme
13. iod 5 2 7 Interruption of lysing cycle by the operator Operators can interrupt a lysing protocol at any moment by pressing the Stop button When a protocol is interrupted by the operator the time remaining is displayed Pushing the button Stop or Start allows the system to go back to the Start menu The vacuum created beneath the indented plate will be released a few seconds after the system has shut down the indented plate cannot be removed during this short period 5 3 Lysing kit use by dates ALARM 6 Alarm messages Lysing kits provided by Bertin Technologies must be used before the use by date indicated at www precellys com Use of lysing kits beyond their use by date may result in sudden damage to tubes WARNING Never open the lid while the metallic support ring is in motion Alarm message Possible cause Action Pressure error Tubes recommended by Bertin Technologies are not correctly positioned in the holder 1 Reposition the lysing tubes in the holder 2 Press on the centre of the indented plate during the vacuum phase lid open The indented plate or tube holder are not positioned correctly Reposition the indented plate on the metallic support ring and ensure that it is positioned correctly using the positioning guide The toric joint is not positioned correctly Reposition the toric joint on the metallic support ring and ensure that it is correctly ad
14. justed to fit on the metallic support ring The indented plate is damaged Replace the indented plate The toric joint is damaged The vacuum circuit is not working correctly Replace the toric joint see 7 2 1 Switch off the unit Contact Bertin Technologies technical support team Lid error Motor error The lid is not closed properly Check that nothing is preventing the lid from closing The detection system is faulty The motor temperature has reached its maximum safety limit Switch off the unit Contact Bertin Technologies technical support team Leave the unit switched on to allow the ventilation system to keep running 2 Ensure that the air intake and extraction vents are unobstructed 3 If after 30 continuous ventilation the alarm message is still displayed contact Bertin Technologies technical support team l 2 1 2 Press the lid and ensure that the handle is locked properly 1 2 l The power supply is not compatible with the equipment Check the coherence of the voltage specified on the rear of the equipment and the voltage delivered by your local electric power supply The speed regulation or detection system is faulty 1 Switch off the unit 2 Contact Bertin Technologies technical support team Page 19 bertin TECHNOLOGIES USER MANUAL PRECELLYS Evolution MAINTENANCE MAINTENANCE 7 dV WARNING 7 Main
15. mage to the internal components or in breakage of the casing e WARNING D To remove the equipment from box do not lift it by holding onto the lid Use either the specially designed extraction handles or the notches located on both sides of the lower casing of the unit For greater convenience notches are also present in the protective foam Given its weight it is advisable that two operators move the unit a E bertin Page 14 TECHNOLOGIES USER MANUAL 3 Transport and storage 3 1 Transport Before transporting the equipment it is essential to 1 Reposition the protective foam to retain the tube holder in place 2 Close the lid 3 Use the original packing components 3 2 Storage The unit must be stored in a dry area at a temperature ranging from 0 C to 50 C 4 Installation INSTALLATION 4 2 Installation and connection to power supply 1 Remove the protective foam located around the metallic support ring and reposition the containment seal see 7 2 2 a WARNING Keep this protective foam in a safe place as it must be put back in place before shipping the unit lf the unit is returned to the distributor or manufacturer without this protection in place the warranty will be cancelled The containment seal must be positioned in compliance with the instructions provided in this user manual in order to ensure optimum operator protection The
16. manual with the voltage delivered by your local electric power supply see 2 1 4 Ensure that the air intake vents and the base of the casing are unobstructed the air extraction vent is located beneath the unit foot air outlet 5 Connect Precellys Evolution to the mains power supply using a compatible power cable A WARNING N l the voltage supplied is not the same as that indicated on the equipment the electronic components of the latter may be ey damaged J dL WARNING Allow a space of at least 10 cm around the air intake and extraction vents A dL WARNING This equipment must be powered from a mains supply equipped with a protective earth ground terminal N J bertin TECHNOLOGIES Page 15 PRECELLYS Evolution INSTRUCTIONS WARNING N Gloves should be worn and all necessary precautions taken with regard to infection related risks when using this equipment and when handling samples N A WARNING N Never open the lid while the metallic support ring Is in motion If the lid is opened while a lysing protocol is in progress the protocol will stop automatically U bertin Page 16 TECHNOLOGIES USER MANUAL 5 Instructions for use 5 1 Preparing samples Samples must be prepared in Precellys Lysing kits recommended by Bertin Technologies a list of which can be found at www precellys c
17. nt seal against the casing For safety purposes and to prevent any damage to the equipment the recommendations listed below should be strictly complied with e Do not spray water or cleaning products directly onto the unit especially the air vents and fan intake e Always disconnect the equipment from the mains before cleaning e Do not use caustic soda or acetone e Do not use an aerial decontamination process 8 1 Recommendations The exterior casing of the unit can be cleaned with a sponge or a damp cloth moistened with water or alcohol bertin Page 22 Page 23 bertin TECHNOLOGIES TECHNOLOGIES PRECELLYS Evolution USER MANUAL CLEANING DECONTAMINATION bertin Page 24 TECHNOLOGIES 8 2 Example decontamination procedure In the event that a tube breaks during a lysing cycle decontaminate parts that may have been contaminated with an appropriate disinfectant The choice of decontamination procedure is the sole responsibility of the user Parts that may have been contaminated can be cleaned with a sponge or a damp cloth moistened with bleach diluted at 6 Cl lf another decontamination procedure Is to be used please first contact our technical support team to ensure that the chosen procedure is compatible with the equipment 9 Repair and Disposal 10 Annex 1 9 1 Repair The equipment must be cleaned and decontaminated in accordance with the procedure described in 8 2 bef
18. om see 1 1 1 Only recommended Bertin Technologies lysing kits should be used Other accessories may impair the protection of the unit 5 2 Launching a lysing protocol 5 2 1 Switching on the equipment Once connected to the power supply the equipment is switched on using the On Off switch on the rear close to the AC power input A few seconds after being switched on the main menu will appear on the control panel screen The operator must then select the desired lysing protocol from the Start menu 5 2 2 Opening the lid To open the lid release the locking handle and raise the lid until it will go no further 5 2 3 Loading lysing tubes Lysing tubes containing samples are positioned in the tube holder and then held in place by the indented plate which must be removed for the loading and unloading of the tube holder The tube holder is removable and is designed in such a way as to allow it to stand on its legs even when fully loaded with tubes It is also possible to operate the equipment when the tube holder is only partially loaded A vacuum system holds the indented plate onto the metallic support ring The prongs of the indented plate retain the tubes in place while the unit is running and the tubes are released when the vacuum pressure is released a few seconds after the end of a lysing cycle INSTRUCTIONS Example of 2mL indented plate and 2 mL tube holder neps N
19. ore shipment for repair The equipment must be sent with a return form see annex 1 indicating Clearly at the very least the procedure used the persons involved and the date on which cleaning and or decontamination was performed lf the return form is missing from the consignment Bertin Technologies after sales team reserves the right to refuse to perform repairs 9 2 Disposal The cleaning and contamination procedure must be performed prior to disposing of the equipment so as to ensure total human and environmental protection The equipment its spare parts and consumables are the object of separate waste collection procedures in accordance with the EU directive pertaining to waste electrical and electronic equipment WEEE 2002 96 EC Bertin Technologies is under no circumstances whatsoever legally bound to take back this equipment Wii Orecenvs com NEW GENERATION Tissue homogenizer SAMPLE PREPARATION amp CELL LYSIS Precellys The Science of Lysing Equipment for Life Sciences return form Reference 17 DIXI DVI Equaymen decontmmnation est Gl the equiped deconbemaon has been executed ani thal the equipment 5 clean and can be red mhi any risk Lin secondance wth the equipment user manual LU Speci decontamination proia Peme delal hi spect poid Meade at ac ted ku be tty awar ht ar y Bl de laratik n mill epo m r b CPR ari raw whese my xupyarmikility xan ld be pariy to a xil F Date
20. stall any unauthorized cards components or Wiring colour codes are as follows accessories as this may impair the safety of the unit and will International US 1 1 1 Use of lysing kits render the warranty void Live code code e Ensure that the voltage indicated on the rear panel of the unit phase Brown Black Depending on the parameters of the Precellys Evolution speed number matches that of the local power supply Neutral Blue White of cycles cycle duration waiting time between two cycles excessive e Ensure that the cable connections are correctly wired Earth Yellow amp G Read the leaflet carefully overheating of the lysing tubes may lead to their sudden degradation Ground Green ie In order to ensure the good working order of this Precellys Evoution equipment users are strongly recommended to use the Lysing Kits produced by Bertin Technologies and to comply with the use by dates specified for each lysing kit These use by dates specify the maximum parameter levels e g speed number of cycles cycle duration waiting time between two cycles etc that must not be exceeded for the good preparation of biological samples Use by dates for our lysing kits are available on our web site www precellys com 1 1 2 Risk of electric shock 1 1 4 Fuse The equipment contains one replaceable external fuse located on the rear panel If the fuse needs to be replaced please use the following fuse 5x20 T 10 A H 250 V Th
21. tenance Prior to any maintenance operation the equipment must be cleaned and decontaminated according to the infection risk associated with the samples being treated and using suitable 7 2 Replacement of spare parts This paragraph specifies the maintenance actions that users must perform on a regular basis in order to ensure the continuous good working order 7 1 Troubleshooting guide of Precellys Evolution The list of the main issues encountered during normal operation and the actions to take are listed in the table below personal protection equipment Upon completion of service and maintenance ensure that the ee is In a safe condition J Wearing part Reference Frequency of replacement Why 2 mL indented plate SP02520 810 NC001 0 1 year or when Essential for maintaining tubes in place Issue Possible cause Action aaa during homogenization encountered 2 mL tube holder SP02520 820 NC001 0 1 year or when Essential for maintaining tubes in place damaged during homogenization The fan is not No power supply to 1 Check the mains voltage i working mains plug 2 Ensure that the voltage of the unit 7 mL indented plate SP02520 810 NC002 0 ce when Fecal for ae tubes in place matches that delivered by the mains power i ee supply 7i m hol SP02520 820 NC002 0 year or when Essential for maintaining tubes in place 3 Ensure
22. that the unit is plugged in properly La ku aa damaged during homogenization Faulty fuse Replace the fuse see 7 2 3 BD NNN SPOZ2S20810 NC003 0 o me ae i ee eg TE Faulty cooling system 1 Switch off the unit aera 2 Contact Bertin Technologies technical 15 mL tube holder P02520 820 NC003 0 year oF when ie support team TESK F SIO 6 months or when Essential for maintaining tubes in place Me display on ee supply to 1 Check the mains voltage Toric joint Sano BN Oy damaged during ance e ioi i e screen mains plug 2 Ensure that the voltage of the unit matches that delivered by the mains power Containment seal SP02520 810 NC004 0 a a eee UL sa Supply 3 Ensure that the unit is plugged in properly Fuse SP02520 810 NC006 0 When blown Faulty fuse Replace the fuse see 7 2 3 Anti rotation kit SP02520 810 NC007 0 ear or when u a a Faulty display system 1 Switch off the unit 2 Contact Bertin Technologies technical support team One or more The cap has not been eS are not properly screwed on or A WARNING tight h is faulty lally ists insi Dedine ye tan bi lt iAA he Potentially dangerous voltage exists inside the instrument In order to oe mance Is not a proper decontamination procedure see ensure user safety in particular during cleaning and or decontamination y 8 procedures the containment seal must not be damaged in any way The limits of use have perforation tear etc not been met Nev
23. tion regarding the unpacking operation and maintenance of the Precellys Evolution homogenizer The technical specifications of this product and all the information contained in this manual are liable to alteration without prior notice USER MANUAL 1 Introduction 1 1 Safety instructions and recommendations This user manual must be read carefully by all users prior to operating the Precellys Evolution lyser homogenizer If the instrument is used in a manner not specified in this manual the insurance provided for the equipment may be impaired If there is any doubt or concern about the safety of the equipment please contact your local distributor Bertin Technologies shall not be liable for any damage or injury that may occur as a result of operating the instrument in a different way to that stated in this document INTRODUCTION 1 1 3 Abnormal operation Operating this equipment in any other way than that described in this user manual may impair the protection of the unit e Never set the unit at an angle Precellys Evolution must always be used when evenly balanced on its 4 feet Failure to comply with this instruction may result in damage to the internal components or in breakage of the plastic casing e High voltage warning do not handle or operate the unit if the casing is wholly or partially removed or is damaged e Do not use or handle the unit when the protective earth is disconnected e Do not in
24. volution is range the manufacturer recommends an operating range to prevent User interface equipped with removable abnormal temperature rise see paragraphs 1 1 1 and 5 3 for further TOET tube holders that offer details __ pad eT ae reater flexibility interms Display features 1 LCD colour screen 16 bit 3 5 amp HEXIOMY For high speed operation users are advised to reduce the duration of each 1 indicator light green and red of handling different t be cycle and to allow the unit to cool down between 2 cycles for at least 2 Capacity types The full list of sample minutes A security device disables the unit to prevent overheating p tubes that can be used with Precellys Evolution is Number of tubes 24 12 6 available at Single tube volume 0 5mL 2 mL 7 mL 15 mL _www precellys com J bertim Page 12 Page 13 bertin TECHNOLOGIES TECHNOLOGIES PRECELLYS Evolution TRANSPORT AND STORAGE dk WARNING Avoid violent shocks that may damage the equipment A WARNING N In case of a large difference of temperature between the storage area and the laboratory let the unit cool to room temperature in order dil the risk of a A WARNING N Do not connect the unit to the power supply until the installation process is complete Never set the unit at an angle Precellys Evolution must always be used when evenly balanced on its 4 feet Failure to comply with this instruction may result in da
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