iSCAN - CANBERRA Industries
Contents
1. A CANBERRA Features Performs Thin Layer Chro matography TLC using an appropriately shielded high resolution Nal detector Performs both chemical purity analysis through TLC scanning and radionuclide purity analysis by means of energy spectrum analysis also known as pulse height analysis PHA Allows automatic storing of PHA spectra together with the chromatogram spectrum scan Full hardware control both scanner and data acquisition system via software Scan can be performed under manual control as well Complete and comprehensive software package with Proto col driven measurements for best reproducibility and quality control All measurements and parameters are stored into a database A specialized data review program is included in the standard software package Windows 2000 and XP platforms supported The Scan is only for sale in Benelux and Denmark Phone contact information ISCAN An Intelligent TLC Radiochromatography Instrument Description The Scan is an intelligent radio chromatography instrument that uses Radioactive Thin Layer Chro matography TLC a well established analytical technique used to identify components in a mixture It is widely used in Nuclear Medicine laborato ries to control the compounding and dispensing of radio active pharmaceu ticals used in nuclear medicine procedures The technique is used as well by producers of radiopharmaceut2. Microsoft Corporation in the United States and or other countries Pentium is a registered trademark of Intel Corporation in the United States and other countries 2007 Canberra Industries Inc All rights reserved DETECTOR TYPE Nal scintillation detector DETECTABLE RADIATION Photons Gamma rays and X rays a DIMENSIONS Typically 2 in x 2 in standard crystal Other sizes can be ordered at an additional price a TYPICAL ENERGY RESOLUTION 8 7 5 at 662 keV COLLIMATORS Set of two collimators of 20 mm thick 0 8 i with apertures of 1 mm and 3 mm 0 04 and 0 12 in SPECTROMETER MCA TYPE CANBERRA s uniSPEC compact MCA as standard option Other CANBERRA acquisition systems are also supported ACQUISITION MODES PHA 1024 channels MCS 1024 channels DWELL TIMES From 0 1 s to 255 s software selectable DATA COMMUNICATION USB Computer Desktop PC compatible system with the following minimum requirements 100 MHz Pentium 16 MB RAM One Serial port RS 232 One free USB connection Windows 2000 or Windows XP Software Scan version 1 2 includes the following modules iScanDB iScan iScanReviewer Supplied in CD ROM together with User s Manual
3. ScanDB The Scan measurements are Protocol driven All the parameters that make up a Protocol the set of different Protocols and the results of all measurements are stored in a relational database Le iran Databacs tanagor Lic Par bard to ss x EEKE Cem a n OSL i toe M eee EMM Greet Aplin eter erator al p a Fea F ha He iScanDB is the program that manages and organizes the database iScan iScan is the main program used to perform the Chroma tography analysis based upon the Protocols previously created The program automatically controls the scanner and data acquisition performs the data visualization and analysis of Chromatogram spectra MCS and if selected the energy spectra PHA The storage and logging of the analysis results into the database is done in unattended mode iScanReviewer Provides the necessary tools for data extraction visual ization manipulation and reanalysis of all chromatogram scans files stored into the database and PC iScanReviewer can produced Quality Control QC charts also Known as trending charts for the mea sured chromatogram scans of a given Protocol or other database fields using several qualifiers Purity Rf Peak area continuum values etc Date constrains can be specified as well With this program stored chromatogram scans files can be re viewed re analyzed or reported i T me Statistical analysis of QC resul
4. icals where quality of the production must be monitored continuously Today a radiochemical purity control is absolutely essential to ensure the accuracy of the radiopharmaceutical based medical analysis At the same time the radionuclide purity of the radiopharmaceutical is a warranty of its efficiency and quality This instrument targets the control and measurement of both characteristics of the radiopharmaceuticals iScan COMPONENTS The Scan instrument is supplied with the following components Hardware Components The programmable scanner A Nal scintillation detector with suitable shielding and set of collimators A compact multichannel analyzer MCA The controlling PC optional Software Components The Scan software package contains three modules ScanDB a database manager Scan the main Chromatography software ScanReviewer for data review and analysis The iScan software package has been designed to automate the TLC analysis particularly Medical Chromatography Benelux Denmark Canberra nv sa Z 1 Research park 80 B 1731 ZELLIK BELGIUM e Tel 82 02 481 85 30 Fax 32 02 481 85 50 E mail info be canberra com For other international representative offices visit our web site http Awww canberra com or contact the CANBERRA U S A office C32799 7 07 Printed in U S A ISCAN An Intelligent TLC Radiochromatography Instrument HARDWARE DETAILS TLC Scanner The Scan scanner is a fu
5. lly 2 x 2 in This detector provides excellent energy resolution and counting efficiency Other sizes can be arranged upon request The detector is mounted inside a shielding housing made of lead that is 10 mm 0 4 in thick on its thinner part The front area of the detector is collimated using a standard 1 mm 0 04 in aperture Collimators of different apertures can be easily mounted in the scanner Another collimator of 3 mm 0 2 in opening is delivered with the instrument MCA The data acquisition system makes use of CANBERRA s compact Multi Channel Analyzer uniSPEC This MCA can operate in two different data acquisition modes Pulse Height Analysis PHA and Multi Chan nel Scaling MCS The first mode is used by Scan to acquire the energy spectrum of the radiopharmaceutical or sample being scanned while the second is used to generate the actual chromatogram during the scan The MCA is built inside the 14 pin socket that is con nected to the Nal detector providing a compact and light assembly The MCA communicates with the controlling PC via any available USB port The MCA can be set up to acquire a maximum of 1024 channels The Dwell times may range from a few ms to minutes The MCA acquisition parameters for both PHA and MCS modes can be set via the software from the controlling PC ISCAN An Intelligent TLC Radiochromatography Instrument SOFTWARE DETAILS The software consists of the following modules i
6. lly programmable instrument Its main function is to sweep the detector across the chromatogram strip The scanner s programmable motor allows several scan ning speeds including user defined ones Parking of the detector advancing to the startup position and returning to the home position are done automati cally under software control A Reset button in the front panel is provided so the user can manually abort the scanning operation at any time The place that holds the strip is engraved in the base of the scanner plate and is 5 mm deep 50 mm wide and 210 mm long 0 2 x 2 0 x 8 3 in There is a convenient ruler placed along the scanning length The communication with the PC is done via a RS 485 interface a RS 485 to RS 232 converter is provided using a standard 9 pin connector located in the back of the device The power supply socket is also located in the back the scanner works directly from 100 240 V ac mains The On Off switch is located at the top right corner of the front panel of the scanner a built in LED signals the power on status There is also a Manual scan button It allows executing a complete scan operation using a single speed fixed at the factory without the need of the controlling PC For additional details see the Specifications section in this document Nal Detector The iScan is offered with a high resolution Nal scintilla tion detector having standard option a crystal of typi ca
7. ts can be performed among many other data operations Data can easily be exported to ASCII CVS XML files or directly into Microsoft Excel ISCAN An Intelligent TLC Radiochromatography Instrument Specifications TLC SCANNER MODEL iScan TLC101 DIMENSIONS 37 x 22 x 25 cm 14 6 x 8 7 x 9 8 in WxHxD WEIGHT 16 5 kg 36 4 Ib without detector and MCA POWER SUPPLY 100 240 V 50 60 Hz m FUSES 250 V T2A soldered fuse a SCAN AREA Strips max 50 x 210 mm 2 0 x 8 3 in m SCAN SPEED Automatic 0 1 to 2 cm s 0 04 to 0 8 in Software Selectable Fixed to 0 5 cm s 0 2 in when using Manual scan mode a SCANNER CONTROL via RS 485 RS 232 protocol a STRIP CARRIER One provided 50 x 200 mm 2 0 x 7 9 in engraved in plastic Extra pieces can be provided upon request and at extra cost Metallic ruler 0 240 mm 0 9 4 in mounted along the scanning path FRONT SWITCHES BUTTONS AND LEDs On Off switch with LED power on indicator Manual scan push button Scanner reset push button Blue LED signaling Busy state BACK CONNECTORS 3 contact standard 100 240 V mains socket 9 pin RS 485 RS 232 connector a SHIELDING 10 mm minimum of lead Pb around the detector EXTRAS EU 220 V power cord RS 232 RS 485 data cable RS 485 to RS 232 adaptor optional Microsoft and Windows are registered trademarks of
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