ExiPrep™16 Dx
Contents
1. Innovation Value Discovery ExiPrep 16 Dx Fully Automated Nucleic Acid Extraction System ll Safety Warnings and Precautions The warnings and precautions stated below are for the correct and safe operation of the instrument Please heed all information for your safety Bioneer Corporation does not assume responsibility for non compliance with the safety warnings and precautions stated below 1 1 User and experimental precautions Make sure that the power supply 100 240V 50 60HZ is correctly connected to the power adapter and that the power adapter is correctly connected to the instrument Incorrect connection of the power adapter and power supply can result in instrument damage or failure to turn on This instrument is intended for nucleic acid extraction Please use as such The instrument may stop if the LCD panel is touched while connected to a PC via LAN cable If operating the instrument via PC software please allow for the instrument to finish its programmed movement before operating the LCD panel Do not turn the PC off or disconnect the LAN cable connecting the PC to the instrument Data communication error can result in instrument malfunction and can affect the results of your experiment Please install the instrument on a flat surface Do not operate the instrument with wet hands as this may result in shock or instrument malfunction Please touch the power adapter cord with dry hands If the instrumen2. doesn t move A4 210X297 ExiPrep 16 Dx Fully Automated Nucleic Acid Extraction System Check if there are any obstacles or residues that may interrupt moving the base plate Check if all the accessories are inserted correctly Request for After Service Check if base plate is located in the correct Check if the pair of magnet attached to the door is correctly attached Check if the switch installed at the end of the base plate slide rail is damaged when base plate is pulled out Request for After Service Check inside of the system if there are any obstacles or residues that may interrupt moving the base plate Check the front of the system if there are any obstacles or residues that may interrupt moving the base plate Request for After Service Check if all the accessories are located in the right position Check if there are any residues in each accessories and the rack Check if any accessories and the rack s lock pins are bent or damaged Request for After Service Check if the door is completely closed Check if the tip and the tip rack is inserted correctly While inserting the tips check if any residues or accessories are stuck Check if Stop or Pause button is pressed Check if the provided tips are inserted Check if the tip is bent or damaged Request for After Service Make sure the front door is closed When the block is being moved check if any residues or accessories ar
3. selection A popup prompting user input on the usage of the Buffer Cartridges will appear Inspect the Buffer Cartridges and mark the used wells by clicking on the corresponding locations Select OK to finish SE H Diagnosis Kit CNM QL ES Nucleic Acid Type Genomic DNA v Diagnosis Kit Nucleic Acid Ty Sample Source Type X Sample Source Strip 1 A4 210X297 19 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System VI ExiStation Manager Software continued 7 The program will automatically allocate the NTC and PC wells The default setting is one 1 each of NTC and PC The number of NTC and PC wells can be changed through the ExiStation Manager Software 8 Samples needing re examination will be displayed during this step Select the samples to re examine and the software will automatically assign them to the appropriate wells Re Prep List cel S Sample Mame Bioneere blood sample Bioneers blood sample Bioneerz3 blood sample Bianeered blood sample Bianeer2s blood sample Bioneer26 blood sample Bioneere blood sample DOSS 9 The locations of the non template control NTC and positive control PC will be automatically allocated The default settings are one each of NTC and PC To modify the default NTC and PC replicates go to the Config gt Settings menu of the ExiStation Manager Software window Sa
4. ExiPrep 16 Dx Setup 1 Main Menu R Once the initialization has completed successfully the LCD touchscreen will display the MENU as shown below m Please contact Bioneer Customer Service or your local sales representative if the initialization progress bar does not change for over 5 minutes during initialization or if the MENU screen does not appear after initialization MENU T EP fe Start UV lamp Setup Ej Sj S Main Menu ban Description O R Network Connection gt This icon allows you to determine if the ExiPrep 16 Dx is connected to the PC If the icon is present it means that the instrument is connected to the PC via network and is possible to use the ExiStation Manager Software to control the instrument RB Cooling Fan Operation gt The Cooling Fan icon allows you to determine the status of the cooling fan STORE OFF means that the cooling fan is not operating and STORE ON means that the cooling fan is currently running In order to keep the diagnostic kits refrigerated you must press this icon on the LCD touchscreen or click the STORE ON icon in the ExiStation Manager Software to turn the cooling fan on Contamination protection accessory installation gt This icon is to determine the status of the syringe block for setting the Tip Protector and the contamination shield gt This icon is to be pressed when power rebooting the instrument A4 210X297 24 BiONEER I
5. Innovation Value Discovery ExiPrep 16 Dx Fully Automated Nucleic Acid Extraction System VII ExiPrep 16 Dx Setup continued 3 Viewing Run History If the login option is enabled the user ID process type and run status of each run is saved Up to 99 most recent runs are saved in memory MENU Press the Setup button to access the SETUP menu m UV lamp setup STORE Wisc ls OFF SET 2 Press the History button to view the instrument run history a SP OS User Config History 3 The run history contains the following parameters gt No Recent runs have a lower number a ka gt User ID The 6 digit user ID wa gt Work An abbreviation of sample source and protocol type selected for that run gt Status Instrument report on whether nucleic acid extraction was successfully completed OK stopped during the run Abort or cancelled by the user Canceled A4 210X297 29 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System Vil ExiPrep 16 Dx Setup continued 4 Managing the Login Mode The instrument provides a login mode for restricting non registered use Without a user ID you would have limited access to instrument functions Do not forget your user ID Press the Setup button to access the SETUP menu MENU H E UV lamp Store Misc r OFF SET Pa L agi Press the Config butt
6. 6 A4 210X297 1 Open the door and remove the Screw A from the rail 2 Remove the Holding plate B from the rail and the Syringe Block 3 Remove the Screw C from the locking block which immobilizes the belt 4 Separate the holding block D E from the belt and remove it 8 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System IV Installing the ExiPrep 16 Dx continued 5 Connect the power cable to the rear of the instrument 6 Turn on the instrument A power button will display on the LCD touch screen to indicate normal power on STARTING 7 Press the power button on the LCD screen to initialize the instrument A progress bar on the lower portion of the LCD L EYiPren 16 touchscreen will indicate initialization progress Ferrrrrrrrrerer 8 Open the door and remove the Sponge block F from the Base Plate after initialization gH HHHH HTS X PC connect mode 9 Connect the network hub power adapter to the network hub and plug the adapter into a wall outlet A4 210X297 9 BiONEER Innovation Value Discovery ExiPrep 16 Dx Fully Automated Nucleic Acid Extraction System IV Installing the ExiPrep 16 Dx continued 10 Connect the instrument to the network hub using a LAN cable 11 Connect a LAN cable between the network hub and the PC which has the ExiStation M
7. BIONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System IX DNA RNA Extraction Program Number List No Target Sampiesource No Target Sample source FH 01 Genomic NA Whole bio Ber Toeren Whole bood 02 Genomic DNA Animal issue 2 o2 Tol RNA aaae os Genomic DNA lere 2 o8 Tain eers 04 Genomic DNA laes B08 Tom RNA Pantissue 77 05 Tota RNA eet 05 GenomicONA Rie BOS toarna Re 07 Genomic NA Testa 2 o7 aane aa 08 Genome DNA Tenis 2 o8 Tol RNA Gram bacteria 08 Genomic DNA Gram bacteia 2 09 To RNA esse 10 Genomic DNA Yeast 2 10 toarna Yeast II m Genomic wA Fong 2 n toarna Fong 12 Genomic ONA Proma 2 12 toarna Pera Ta GenomicOna seum 2 13 TowlRNA serum 14 Genomic ona Tae 2 14 aine Butycomt 15 Genomio DNA spun 2 18 Tans Sputum 16 GenomicONA Jea 2 w toarna en 8 cenomeona swo 2 8 toarna swo 19 Geromieona urne 2 19 Toana urme 7 2 ceromeona se 2 toarna Stoo 21 Genome ONA leae 2 21 Tok RNA ears vody tuid 22 Genomic DNA lna 2 22 toarna Pewarna 2 Genomicona os 2 toarna es 24 ceromeona ers 2 2s toarna es 125 Genomic DNA Respraiory sample 2 25 Taa RNA Respirator sampe 26 Genomic DNA Annioictiis 2 28 Toara east 28 Genomic DNA Bonemanow 2 2B Tok RNA Bonemarow 2 G
8. ExiPrep 16 Dx Setup continued 7 Administrator continued Admin PW Change R Administrator ID change menu gt Enter a new 6 digit administrator ID using the keypad in the 9 EJ EJ 9 9 middle of LCD touchscreen and press Enter button to oe fee for ee S save ror Ya for ee for Si Admin PW Change Press the ok button to save new administrator ID after verifying the new administrator ID You may now use the new administrator ID to delete user 9 9 9 9 9 9 IDs or setup and configure the system Do not forget new administrator ID kd A4 210X297 34 BIONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System VIII Updating the ExiPrep 16 Dx R Updating software may improve instrument functionality and install up to date protocols for nucleic acid extraction m Please refer to the FAQ in our homepage or contact Bioneer Service Center if updating does not progress as described below or you have questions NOTE This program NOT included with the instrument If you want to the program you have to request to us 1 Connect ExiPreo 16 Dx to your computer using Cross type LAN cable 2 Start the installation of the downloaded program below gt The IP address and network hub LAN port settings may change depending on the installation site and PC ES ExiStation ExiPrep Pro Plus DX Protocol Update Software Bioneer C 1 Execute the program 2 Click the IP am
9. Mode 31 6 AONGEA wA AA WA ka WA NA ee i AA i 32 7 Administrator Mana Mi lees eM aie laden hoe ced 2 oad etchant a 33 VIII Updating the ExiPrep 16 DX 35 IX DNA RNA Extraction Program Number LUIS sss 38 Ae Trou DleShooUNg sr oie sea acess a tnt a ad eee a T 42 Ae UU AU MANN IA AAA learn eG esa aaa aw 46 Copyright 2011 by Bioneer Corporation All rights reserved EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System l Getting Started Thank you for purchasing this Bioneer product We will try our best to provide satisfactory results to our customers This manual contains practical guidelines and cautions to be taken regarding the instrument Please read this manual carefully and thoroughly before using the instrument Website Please visit us online at http www bioneer com to obtain more information about ExiPrep 16 Dx General information x ExiPreo 16 Dx is a trademark of Bioneer Corporation The information contained in this manual is under copyright protection It is unlawful to reproduce part or all of the contents of this manual without the expressed written consent of Bioneer Corporation Bioneer Corporation reserves the right to alter modify and otherwise make changes to the instrument and manuals without prior notice You must be used carefully UV Lamp Detail can be found in Safety warning and Precautions Reversion Cat Number A 5050 Rev 1 0 March 2011 A4 210X297 1 BiONEER
10. R The sterilization runs for 5 minutes The progress can be tracked through the progress bar displayed on the bottom portion of the LCD touchscreen To cancel the sterilization process press the UV lamp button again R You may also use the ExiStation Manager Software to toggle the UV sterilization function A4 210X297 26 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System VII ExiPrep 16 Dx Setup Continued 1 Main Menu continued 3 System setup menu SETUP MENU SETUP as S JI User Config History SELF TIP s OUT Fp TEST Up Setup Screen R User registration menu gt You may create new accounts through this menu Details on account creation can be found in page 28 gt Allows you to restrict non registered users from accessing features such as UV sterilization and system preferences Details on system configuration can be found in page 32 R History Enabled by selecting the user login option Allows you to audit up to 99 most recent runs by displaying information such as user ID operation record and the instrument status successful cancelled of a particular run Details can be found in page 29 Self Test gt This icon is for testing each motor initialization and heater block Temperature gt This icon is for removing the Disposable Tips from the instrument syringe Block Pressing this icon
11. cancel the stop and proceed with the extraction run KAINI You may select PAUSE to temporarily stop the run and RUN to resume A4 210X297 15 BiONEER Innovation Value Discovery ExiPrep 16 Dx Fully Automated Nucleic Acid Extraction System 3 RUN Not used PC Continued 13 After the extraction run is complete pull out the Base Plate and Work Completion remove the Elution tubes Buffer Cartridges and all racks from the Base Plate After removing all accessories push the Base Completely remove all the parts from ExiPrep and close the door Plate back in completely and close the door 1 Still remains same work You are given three options at this point 2 Do other work l i OK Finish Still remains same work Repeat the current protocol r Do other work Perform an extraction run using a different 1 2 ok j l h 1 protocol for another nucleic acid and sample source type Finish Finish and exit If the automatic UV sterilization option is enabled a popup prompt will appear warning you not to open the door as UV UV Sterilization sterilization is in progress Details can be found in page 31 16 Press the START button to initiate sterilization Warning gt Select SKIP if you wish to pass sterilization Do not open the door 17 The sterilization process takes 5 minutes Progress can be AALI checked through the progress bar 18 Remove the contamination pro
12. dry Wet or moist hands may cause electric shock 4 Avoid placing objects in the front and rear of the instrument 5 Avoid installing the instrument in a dusty environment Excessive dust may cause malfunction or damage to the instrument 6 Avoid installation near heat sources This can cause fire 7 Avoid installation near sources of water or damp locations This can cause electrical shock fire or instrument malfunction 8 Do not install near sources of flammable or corrosive gas If there is a gas leak do not touch the power plug but open a window to circulate fresh air Sparks from the power plug can cause fire and explosions 9 Do not disassemble or modify the instrument in any way This can result in fire electrical shock or malfunction and also voids your warranty 3 Precautions and warnings regarding instrument installation 1 This is a precision instrument Do not install in a location exposed to direct sunlight 2 Install the instrument on a flat solid surface that is flat and does not move 3 When installing the instrument make sure at least 15 cm separate the instrument from the nearest wall 4 Take caution not to damage the cooling fan mesh located on the front bottom while installing 5 When connecting the PC network hub and ExiPrep 16 Dx do so with all involved components powered off Connecting components while the power is on may cause damage to the instrument 6 Verify the network cable integrity w
13. is ON 4 Verify the PC network settings 5 Make sure the instrument control software is installed in the correct folder 6 Request service from your dealer Actual instrument operation is 1 Check to see if the Start button was pressed more than twice different from the expected 2 Check to see if the software is executed twice 3 Restart the instrument and software 4 Request service from your dealer No buttons or pictures are 1 Erase and re install the software displayed within the software A4 210X297 45 BiONEER Innovation Value Discovery ExiPrep 16 Dx Fully Automated Nucleic Acid Extraction System KI Warranty This instrument is warranted by Bioneer against manufacturing defects in materials and workmanship for a limited warranty period of one 1 year from the date you received your product Bioneer will either 1 repair the product at no charge if a hardware defect is found or 2 exchange the product if the same hardware defect arises more than three times during the limited warranty period Any other accessories other than the instrument itself are considered as consumables and warranted for three months Spare parts for the instrument will be available for five years from the initial instrument release date If a defect arises after the limited warranty period shipping and handling charges may apply to any repairs or exchanges of the product undertaken by Bioneer Exclusions and limit
14. ExiPrep Pro Plus DX Protocol Update Software Bioneer C x 100 BiONEER IP amp Select Mem oryChecklError Count 07 138240 1 Upda Update ead memory matches i O N E E R IP amp Select Finish 7 10 11 12 13 14 15 16 If the connection fails the connect fail prompt will be displayed In this case reboot the instrument and network hub and verify that the network cable is connected correctly Also verify the PC network settings including the IP address After the connection is completed click the Update button on the right side Wait until the progress bar is full gt If the connection stops progressing restart the update process from step 1 Once the connection process is done Memory Check starts window will pop up Click OK gt Ifthe connection stops progressing restart the update process from step 1 Once Memory Check starts the progress status bar will be displayed When the Memory Check finishes the progress Write and Read memory check results to matches window will pop up Press OK button If you get the Finish message on the progress bar all the update process Disconnect the LAN cable from the computer and the instrument Reboot the instrument and reconnect the LAN cable Xx The IP address may change depending on the installation site and PC A4 210X297 36 BiONEER Invov
15. Press the UV lamp button again to disable the mode A popup prompt UV Mode OFF appears and the UV Lamp System Setup icon will turn white UV lamp Config A4 210X297 31 BIONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System Vil ExiPrep 16 Dx Setup continued 6 Configuring the System Only the single user with a registered administrator ID is able to configure the system Do not forget the administrator ID iq h System Setup Press the Config Button from the System Setup menu to access the System Config menu System Config Ej z ma a E S R R Screen Bnghi Admin Factory Calibrates the Adjusts the Manages user Accessible screen position screen IDs as well as only by brightness administrator authorized ID engineers Cali a Screen Screen Calibrates the screen position gt Calibrate the screen position relative to touching gt Press and hold the circle at the upper left corner with a C4 i TM i ExiPrep 16 blunt tool for 2 seconds gt Press and hold the circle at the bottom right corner with a blunt tool for 2 seconds 3 Nr R Bright Screen brightness adjustment Bright gt Adjust the brightness of the LCD touchscreen using the and buttons LAA Press the ok button to save the adjusted brightness level The previous menu will be displayed when the new brightness setting is successfully applied To r
16. User Manual Ver 1 0 ExiPrep 16 Dx Fully Automated Nucleic Acid Extraction System BiONEER Innovation gt Value Discovery Contents k Geng Started Ia 1 ll Safety Warnings and Precautions sese eee eee e e e e e 2 1 User ana Sperimentali sie AA AAA AAA AAA WAA WAA AA 2 2 Precautions regarding the operation environment sees 2 3 Precautions and warnings regarding instrument installation wws wwswmsommsemmsemeso ms mwewa sms 3 4 Precautions and warnings regarding instrument Operation esse 3 5 Precautions and warnings regarding product usage ANd MAINTENANCE 2 0 esse 4 Ce ULIM aanerer a E E E EE E 5 lll System Components and Specifications 6 1 SIE COMPONENTS nirre A 6 Di SN anaa Sw Te eR eg SR Ee I PT Sein eee rn ore 7 S ET 19 9 WA AA eT O 7 IVe INSTAIING Me ExiPrep I6 DA aa 8 Ne DNA RNA ii ia 11 1 Contamination Protection Accessory Installation sese 11 2 Sample Prepa atio isre ea E a a adele ee cede 12 3 RUN Not sed PC Aa 14 VI ExiStation Manager Software cce eee e e e e e e e e e dees aie nidaceniaewbhakenteubaeee ee pane oman ass 18 VII EviPrep 16 Dx Setup 24 1 Malm C AAA AA AA AAA WA AA AAA E 24 2 REGINA 28 ie MABWAWA RIS O AA eee ee AA AA eee 29 A Managing the Login lele onssas sbaseeceestasencanutdeh czar age a oan aero 30 5 Managing the Automatic UV SteriliZation
17. anager Software installed 12 Installation of the instrument is complete aa k Da k if Com puter A4 210X297 10 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System V DNA RNA Extraction 1 Contamination Protection Accessory Installation From the Menu screen click MISC SET gt Pull out the Syringe block all the way front outside Contamination Shield and Tip Protector NOTE Load button of ExiStation S W perform the same function with MISC SET button m m ay CAUTION OFF SET H UV lamp In order to use protection accessory this must be installed on the Base plate accessory Place the Tip Protector on top of the Syringe block and insert it into two holding shafts gt Make sure front and rear are properly inserted gt Do NOT FORCE to insert the Tip Protector It may damage 3 Place the Contamination Shield on the lower right side of the Syringe block gt Contamination Shield has a magnet which means if you place on the upside down right it will stick to the holding bar From the Menu screen click MISC SET gt The base plate moves back to the initialization position inside the instrument UV lamp NOTE ca MISC j Load button of ExiStation S W perform the same function OFF SET with MISC SET button A4 210X297 11 BiONEER Invovetion Va
18. ations This warranty does not apply a to cosmetic damage including but not limited to scratches dents and broken plastic on ports b to damage caused by accident abuse misuse flood fire earthquake or other external causes c to a product or part that has been modified in any way without explicit written consent of Bioneer or d to damage cause by any services performed by unauthorized engineers or service providers Obtaining Warranty Service Please review this User Manual and access the online support referred to in the manual accompanying this product before requesting warranty service If the product is still not functioning properly contact Bioneer Customer Service at Bioneer Corporation Headquarters 49 3 Munpyeong dong Daedeok gu Daejeon 306 220 South Korea Phone 82 42 930 8777 Fax 82 42 930 8666 Email sales bioneer com Web site www bioneer com Bioneer Inc 1000 Atlantic Avenue Alameda CA 94501 Phone 1 877 264 4300 Fax 1 510 865 0350 Email order usa bioneer com WebSite us bioneer com Bioneer China 403 Room Building 88 number 887 Zuchongzhi Road Zhangjiang High Technology Park PuDong new District Shanghai 201203 China Tel 86 21 5080 0969 Fax 86 21 5080 1620 E mail ascn bioneer com Web site http china bioneer com A4 210X297 46 BiONEER Innovation Value Discovery
19. ction System VI ExiStation Manager Software 1 Press the instrument power button located on the upper right side to turn the instrument on Initialize the instrument by pressing the power icon initially displayed on the LCD touch screen 2 Execute the ExiStation Manager Software on the computer Bioneer Sra qPCR Allocation Queue T HBV QN ES 9 T IFB QL ES 16 T MTB QL ES 11 qPCR Run Queue 3 Clicking on the ExiPreo image will execute the ExiPreo 16 Dx control software module The software module is pictured below Bioneer ExistationPrep ius ms s S yy Diagnosis Kit Diagnosis Kit Diagnosis Kit Nucleic Acid Type i Nucleic Acid Type Nucleic Acid Type Sample Source Type Sample Source Type Sample Source Type A4 210X297 18 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System VI ExiStation Manager Software continued 4 Click the pull down arrow for Diagnosis Kit A popup will appear Zaa career YA Diagnosis Kit Hucleic Acid Type l Sample Source Type Fixed Nede Z mn 7 E zu ExiPrep 2 ExiPrep 3 HBV QN ES MTB OL ES Do not use CMV QN ES CNM QL ES CPN QL ES ExiPrep 2 ExiPrep 3 E Se L HIV ON FS 6 Select and verify the Sample Source Type
20. e stuck Check if the cartridge is inserted correctly Check if Stop or Pause button is pressed Request for After Service 43 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System It stops while operating 1 Check if the power supplied into the system 2 Check if the Power switch has been pressed 3 In the lower part of LCD screen check if there is a delay in the blue progress bar 4 Check if you have pressed Pause by mistake 5 Request for After Service The System is running but there 1 Check if wrong protocol has been used is an error 2 Check if there is an error in the motor while operating during the movement of syringe block due to residues or accessories being stuck Check if it is operating after rerunning the same program Request for After Service The system is working but it does 1 Check if Elution rack and tubes are inserted appropriately not do the elution Check if the tips are inserted completely Check if the end of the tip is clogged Check if sample is inserted into the cartridge Check if there is any leakage in the syringe block Request for After Service There is a leakage in the syringe 1 Stop using the well that were being used and request of after block service The liquid is dripping in the 1 Check ifthe rack and the waste tray and other accessories are bottom of the system inserted in the right
21. enomicONA eons 2 toarna eoe 20 Genome DNA laea 2 20 Tol RNA Drewbood spot 1 o1 Genomicona s T 2a moara fsa 2 GenomicONA nar 2 2 toarna rar 9 Genome DNA Cen supemaiani 2 28 Tol RNA raire A4 210X297 38 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System no Target Sample source No Target grasse ov mRNA Wole bloo MOF wr DNA Whee boos 02 mena amare A 02 vralONA amaes 0a mena eas A 03 verona ees oa mena Rate a oa varoma Rate o mea Plntseed a o5 vralONA panet 05 ma Re fe waona Re aor mema cuac a o7 waona Cotwedcal 08 mRNA oram toeea R vrerona Gram 6 bacteria w mRNA eanes a 09 vrerona Gram aciera w ma Yeas feo vona Yeast n ma fan van mea Plasma Jan vona Peme am mema enn a 49 waona sem a ma eyo a4 vona Rea ma aan fais waona aa w ma e fe weona fee oO w ma svo faw waona Swed w mema ome a waona ome w ma Soo i waona so a mRNA _ Ceitesbowytuid a 21 vralONA Cottee boy id 2 mRNA Remain a 22 vralONA Raah a ma o jee waon o a ma fes faa waona es a2 mema aeaaaee a 28 wr DNA Respratory sample 2 mRNA amoina a 28 vralONA aaaea mRNA Bonemarow a 28 vralONA Rener 2 ma eoe fe veon ome o mRNA meea a 20 vrarona Dred ood spot an mma soi a at waona fsa
22. etion Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System x If the PC fails to connect to the instrument try the following steps A Name 1 Select Local Area Connection from the control panel LAN or High Speed Internet SEE 2 Right click the connection and select Properties Bridge Connectors reste Shorbout PNI F 3 Select Internet Protocol TCP IP General Authenbesbon Advanced Connect using ND Brosdeom Netreme 572 Gigab Ce Congue This Coret fa 6 ues the fols tens Z E Cert for Mactomolt Networks kai Fie and Printer Shaarg lor Microsol Nelventks DoS Packet Schedles Tal S 5 x 4 Select Use the following IP address ternet Protocol TOAIP Properties ali Genel Alemate Configuration Tou can get IF peling az25 ned aulomabcaly 9 pour Nabwa suppects this capabili Qihemase you need bo aik pour nebo achraratirabor bee the ape r t e IP selaras CO Oban an IP address automatically T Use the kodowang 1P address Peete specs Pai at 5 Enter the IP address subnet mask Default gateway rae T ES and DNS server address information below BET ee IP address 10 10 104 38 SHL AA Subnet mask 255 255 192 0 PETA Default gateway 10 10 100 1 Preferred DNS server 10 10 111 3 Alternate DNS server 10 10 111 4 LER 6 Click the OK button commit the network changes A4 210X297 37
23. eturn to the previous menu without saving the adjustments press the up button x Factory A S menu Only authorized service engineers may access this menu to service the instrument A4 210X297 32 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System Vil ExiPrep 16 Dx Setup continued 7 Administrator Management Press the Admin button from the System Config menu to System Config yr i Screen Bright Admin Factory access the Admin Access menu Admin Access Enter the 6 digit administrator ID using the keypad on the LCD touchscreen 0 0 0 o KA Press the Enter button oe H for ee iS or wa For EJI TO Delete Clear Enter J Admin Menu 4 The Admin Menu screen includes an option to delete user IDs or change the administrator ID Aaa lar mode gt Select User list delete 1 to delete unused IDs 1 User list delete 2 Administrator password change gt Select Administrator password change 2 to change the factory default administrator ID E User list delete menu User List Registered User Displays the number of registered users Registered User 3 I Select the user ID you wish to delete and press ok to confirm deletion Use the back or next buttons to navigate the pages A4 210X297 33 BiONEER EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System Vil
24. g from this type of exposure may be irreparable 7 Disassembly and or modification of the instrument voids the warranty and may be refused service 8 Do not unplug the power adapter from the instrument while the instrument is in use This may cause the instrument to break 9 If a burning smell is detected or the instrument seems to be excessively hot during operation immediately stop using the instrument and call your service representative 10 Do not drop or impact the instrument This is a direct cause of instrument damage and may void the warranty 11 Always verify that the Heating Block is in normal position before pulling out the Base Plate If the Base Plate is pulled out while the Heating Block is not in its normal initialized position the interference in movement can cause Heating Block and other internal component damage and lead to instrument malfunction Since installed Buffer Cartridges obscure the view re initialize the instrument or take out the Buffer Cartridges and visually inspect the position of the Heating Block before pulling out the Base Plate 12 N Take caution not to damage the cooling fan mesh located on the front bottom of the instrument If the mesh is damaged and the Cooling Fan does not work the Cooling Fan motor and cooling element may overheat and cause fire A4 210X297 4 BiONEER Invovetion Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System 13 The inst
25. g the punch tool in the same pattern as Buffer Cartridge Place back the punched Cartridge on the Setup Tray Insert the sample tube on to the rack according to the number of samples L E 2 gu mai Insert the sample into the sample tube Place the sample tube rack from step 11 onto the Setup Tray 13 Place the Waste Tray on the Setup Tray between the tube rack and the Buffer Cartridge A4 210X297 13 BiONEER EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System 3 RUN Not used PC 1 Connect the power cable to the rear of the instrument and separate the LAN cable of the instrument Press the Store Of button to turn the Cooling Block and cooling fan on The Cooling Block maintains the Elution Tube Rack at a low temperature to keep the eluted nucleic acids and UV lamp nucleic acid diagnostic kit mix refrigerated T YA STORE MISC OFF SET Press the START button to access the PREP SETUP screen T F g Start UV lamp Selup si Refer to the code list within this Manual or purchased Kit Manual PREP Salk T ajoja Prep Type H Sample SRC Whole blood Verify the Prep Type and Sample SRC of the three digit code oe eee for ee S to select the three digit code 38 page applicable to your desired nucleic acid and sample source type you have entered dhi 8 KA 0 Press the Enter button to access the elution volume Clea
26. hen connecting between the PC network hub and ExiPrep 16 Dx Unstable network connections may result in invalid experimental data from data communication errors 4 Precautions and warnings regarding instrument operation 1 Dust off the power plug and insert the plug so that the connection is firm and does not wiggle Incomplete electrical contacts may cause fire 2 Operate the instrument in an ambient temperature range of 15 C 30 C Excessive exposure to heat may affect the instrument and yield inexact results 3 Operate the instrument within the recommended humidity range 20 80 no condensation Humid conditions may cause corrosion or malfunction 4 Donot place any objects next to or behind the instrument The instrument may malfunction 5 This instrument contains precision machined parts Do not drop or severely agitate the instrument This can break the instrument and compromise the safety of the product 6 When not using the instrument for a long period of time turn the instrument off and unplug from the wall outlet Overheating and fire may occur 7 Take caution not to damage the cooling fan mesh located on the front bottom of the instrument If A4 210X297 3 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System the mesh is damaged and the Cooling Fan does not work the Cooling Fan motor and cooling element may overheat and cause fire 8 Set your PC s Power Opt
27. hether the system is initiating 7 Request for After Service LCD Screen is not on 1 It may be interior problem of the system call for the After Service The system does not operate 1 Check if the bracket lock is removed even RUN button is pressed 2 Check if the system is initiating normally when the power is on 3 Check if there are any residues or obstacles in the system that may interrupt operating 4 Check if all the accessories are inserted correctly 5 Check if other buttons in the LCD are working 6 Request for After Service The system is running but does 1 Check if the base plate is placed correctly not operate correctly 2 Check if there is remaining residues or any obstacles that may interrupt operating the system Check if all the accessories are inserted correctly 3 4 Reguest for After Service The front door does not close 1 Check if the base plate is placed correctly 2 After holding the door to open and when releasing the door to be closed check if the door is closed automatically by the spring 3 Request for After Service A4 210X297 42 BiONEER Innovation Value Discovery completely The system is not working even if the door is closed The base plate does not slide out completely The accessories are not being able insert During the operation the syringe block does not pin down the tips Syringe Block is correctly eguipped with the tips but it
28. iStation Manager Software continued Diagnosis Kit CNM GQL ES Diagnosis Kit HBY QN ES Diagnosis Kit Nucleic Acid Type Genomic DNA Nucleic Acid Type Viral DNA Nucleic Acid Type Sample Source Type Gram Bacteria Sample Source Type Serum Sample Source Type Strip 1 Strip 2 13 Click the RUN gt T button to initiate nucleic acid extraction 14 After the extraction is complete remove the samples Diagnostic Kit tubes containing eluted material and immediately run real time PCR 15 Pull out the Base Plate and remove all accessories including Elution tubes Buffer Cartridges and Tips After all accessories are removed push the Base Plate back completely and close the door 16 Press the UV On button to initiate UV sterilization of the instrument chamber A4 210X297 22 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System VI ExiStation Manager Software continued 17 The UV sterilization process will take 5 minutes Progress can be verified through the progress bar displayed on the instrument LCD touchscreen panel 18 After click on the Load button removes the tip protector and the contamination shield A4 210X297 23 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System Vil
29. ions for Turn off the display Turn off the hard disk Standby mode and Sleep mode to Never Because the instrument continuously transmits and receives data from the PC hard disk power down may cause malfunctions 9 The instrument automatically turns off the UV lamp and its operation when the instrument s door is open However just in case it does NOT turns off when the door is open please make sure the UV light does not directly expose to your eyes and skin 5 Precautions and warnings regarding product usage and maintenance 1 This product must only be used for nucleic acid extraction and automatic aliquot Do not use the instrument for any use other than explicitly stated in the User Manual 2 Donot modify or delete instrument related information installed within the instrument 3 Operate the LCD touchscreen using a non sharp object Nails and other sharp objects may damage the product 4 The instrument UV lamp will only operate if the door is completely shut Make sure the door sensor is free of foreign materials or obstructions 5 Do not use powerful detergents or solvents to clean the outside of the instrument as this may cause discoloration If such chemicals are spilled on the instrument immediately clean with a soft cloth 6 Do not keep the instrument in an environment with high humidity Damage from storage in these conditions is classified as water damage and is not covered by warranty Also damage arisin
30. lue Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System 2 Sample Preparation 1 Place Setup tray A on a flat surfaced desk 2 On the Setup tray put on the Buffer Cartridge BY Disposable tip rack C gt Setup Tray and Tip Rack are supplied with ExiPrep 16 Dx gt Buffer Cartridge Disposable Tip and Elution Tube are supplied in the DNA RNA Extraction Kit Place the Disposable tip D for the elution on to the Disposable tip rack Check DNA RNA extraction Kit for the samples and the nucleic types to be extracted Place the number of sample tube from the diagnostic kit and the diagnosis kit tube to be extracted on the Elution tube rack You may cut the strips if necessary to match the number tubes to samples Make sure front and rear sides of the Elution tube rack before placing tubes 6 Check the position of the diagnosis kit tubes in the rack Place the Protection Cap F on to the rack until it clicks into place gt DO NOT press too hard on the Protection Cap A4 210X297 12 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System 2 Sample Preparation Continued Punch holes in the sealing film of Buffer Cartridge corresponding to the relative location and number of tubes and tips using the punch tool Punch holes in sealing the film of Buffer Cartridge usin
31. mple ID Sample ID AZ B2 C2 D2 E F2 Lad H2 AZ Be C2 D2 E F2 G2 H2 M B CO DI EL Fi G1 HI A Bi DI E1 Fi Gi Hi A4 210X297 20 BiONEER Innovation Value Discovery ExiPrep 16 Dx Fully Automated Nucleic Acid Extraction System VI ExiStation Manager Software continued 10 Click the Sample ID box and use a optional barcode reader or keyboard to enter sample information Strip 1 Strip 2 Strip 1 Strip 2 Well Type Sample ID well Ty Fi Al NTC NTC a E _ PA i BI nt EE Ch ms SAMPLE 1 ee e gt 2 kas DI mmm SAMPLE 2 WEL El mm SAMPLE 3 i mE Fi SAMPLE 4 2 Fi a ua Gi prys b Algerian 0 BU TT Save Cancel 11 If you need to change sample ID information click on the well number to summon a popup window You may rename or delete the sample information and move the well to a different location For example to move the sample to a different well select Move from the first drop down menu and select the desired well coordinate from the second drop down menu Edit Well Information _ 7 ename _ Delete Edit Well Information hove 12 Press OK after the desired changes have been made If you need to modify information of other wells repeat steps 10 11 for all relevant wells A4 210X297 21 BiONEER Innovation Value Discovery ExiPrep 16 Dx Fully Automated Nucleic Acid Extraction System VI Ex
32. nnovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System Vil ExiPrep 16 Dx Setup Continued 1 Main Menu continued 1 PREP SETUP MENU T R UV lamp Setup PREP SETUP 1ijoji Prep Type Genomic DNA sample SRC Whole blood me an for H fo Kep m m m Clear Zs L Stare MISC OFF SET 9 MENU Screen PREP SETUP Screen R Selecting Start from the Main Menu will bring up the PREP SETUP screen where you can enter the three digit code for the extraction and sample source type R Refer to the code list within this Manual to select the three digit code 38 page applicable to your desired nucleic acid and sample source type R Do not use this menu when operating the instrument through the ExiStation Manager Software A4 210X297 25 BiONEER Innovation Value Discovery Vil ExiPrep 16 Dx Setup Continued 1 Main Menu continued 2 UV sterilization UV lamp k MENU UV lamp p r STORE MISC 9 OFF SET H le MENU Screen ExiPrep 16 Dx Fully Automated Nucleic Acid Extraction System MENU Start UV lamp Selup FERFEREEEREREEREEERER Store Misc 6 OFF SET d UV Sterilization Screen Use the built in UV lamp to sterilize the internal cavity of the instrument Press the UV lamp icon to initiate the UV sterilization process The icon will turn yellow as UV sterilization proceeds
33. o a mRNA rar fee ON far aa mena consuman S vrarona paeent A4 210X297 39 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System No Target Semple source No Target Sampie source Bor wara hie boos JB o vralONA RNA welewa 02 vraiRWA Anmelissue 6 02 vralDNA RNA Animal issue os warna Teres 6 o8 vrei DNA RNA FFPE tue 77 oa warna Tass o4 whalDNA RNA Pantsu 77 o warna Tana o8 anp reet o warsa re eo aonana Ree 5 o7 warna cuureacoi 6 o7 vralONAIRNA Conwredooh o vraiRWA Tenia 6 08 vralDNA RNA Gram ee o vraiRNA Gram bacteria 00 vrai DNAIRNA Gram bacteria 0 warna ve e 1 wralDNARNA yest m wara rm e n vonar w aa 2 warna peona 6 12 verona Pasma 519 wara seum 6 1 vralONAIRNA seum 4 warna euyo SR vrei nawa Buyon 15 warna spum 18 vrouw RNa Spm 15 warwa Jen e1 anp e m warna swo 6 1 vonar Sad 519 wara ume 6 1 waonwena Une 2 warna so 6 2 anp se 7 a wanna T eaea 6 21 vrei DNARNA Celes body tud 22 warna Pewarta 6 22 via nawa sean 2 wara os e z wralDNARNA cs za warna Jes e 24 vouara es 5 25 warna Respirator sampe 6 25 vra DNA RNA Respirator sample 26 warna Tech 6 28 vrei DNA RNA eaea 2 warna Bonemamow 6 28 vrei DNAIRNA Bonemarow 2 warna Bone e vona
34. on Cab Separation Tool Option Adapter Part Name ExiPrep 16 Dx User s Manual Waste Tray Sample Tube Rack Elution Tube Rack Setup Tray ee E mam WA Aa KA amai Protection Cab Separaton ha OO Optone PCR Preparation Pite for egaa OO PCR preparation plate It is used for ExiStation system instead of Setup tray A4 210X297 6 BiONEER Innovation Value Discovery ExiPrep 16 Dx Fully Automated Nucleic Acid Extraction System 2 Specifications 320 W x 500 H x 525 0 Weight 27 kg Operating temperature 15 30 C Operating humidity 20 80 no condensation Operating system Standalone or PC Electrical Voltage Frequency 100 240 VAC 50 60 Hz Network support TCP IP protocol 320 x 240 touch screen TFT LCD 18 bit color 3 System Views TFT LCD Touch Screen Main Power Butten Door Network Connector Power Jack Cooling Fan Sample Tube Rack Waste Tray Faa an en mT 50 AAA aa Heating Block Buffer Cartridge 2 Buffer Cartridge 1 Elution Tube Rack Dsiposable Tip Rack A4 210X297 7 BIONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System IV Installing the ExiPrep 16 Dx Clear and clean the area where the instrument will be installed Open the instrument door and remove the holding accessories Make sure that all components are included Refer to the list of components on page
35. on to access the System Setup menu SETUP S z SP OD User Config History System Setup 3 Press the User button to enable login mode gt Ifthe login mode is enabled a popup prompt User Mode oe TY ON appears and the user icon will turn blue User UV lamp Config gt Press the User button again to disable user login mode A popup prompt User Mode OFF appears and the user icon will turn white S System Setup User UV lamp Config X Entering an invalid user ID three consecutive times with user login mode enabled will shut down the system Press the Power icon on the LCD touchscreen to restart A4 210X297 30 BiONEER EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System Vil ExiPrep 16 Dx Setup continued 5 Managing the Automatic UV Sterilization Mode The instrument provides an automatic UV Sterilization mode to sterilize the instrument after every DNA RNA extraction run MERIT Press the Setup button to access the SETUP menu WA E UV lamp Store Misc 5 OFF SET Pa he SETUP 2 Press the Config button to access the System Setup menu as oo SO User Config History System Setup 3 Press the UV lamp button to enable automatic UV Sterilization t oe TY gt If automatic UV sterilization is enabled a popup prompt User UV lamp Config UV Mode ON appears and the UV lamp icon will turn yellow gt
36. p Select button on the lower left CIP amp Select Update corner BiONEER r Existation IP amp Machine Select jeer Gi x IP 10 10 104 88 Cancel 3 Anew window IP amp Machine Select will appear with two boxes IP and ID IP amp Select YR amp Machine Select 4 There are two ways of connecting to the 1 o Eee 1 l Cancel 1 and select the instrument ID 2 For example if the IP address is 10 10 104 88 select ID 1 and click OK instrument network gt Directly enter the IP address into the IP box 2 IP amp Machine Select sll 9 Clicking on the small down arrow blue arrow will enable you to select several instrument IDs 10 Me with corresponding IP addresses Click OK to finish connecting to the instrument 1 E 6 If the connection succeeds the Connect BIONEER Succeeded prompt will be displayed Update A4 210X297 35 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System VIII Updating the ExiPrep 16 Dx Continued PI ExiStation ExiPrep Pro Plus DX Protocol Update Software Bioneer C Li mi 239 BiONEER IP amp Select Connect Succeeded R r ExiStation ExiPrep Pro Plus DX Protocol Update Software Bioneer CORPORATION x am Ai g m Memory Check starts IP amp Select The Connection ae ETA BiONEER BS ExiStation
37. position 2 Check if there is a leakage in the syringe block 3 Request for After Service The heater is not working 1 Check if the rack and the waste tray and other accessories are inserted in the right position 2 Check if any solution is dripped in the base plate during the usage 3 Request for After Service There is a burning smell in the 1 Disconnect the power and unplug the power connector system immediately 2 Request for After Service UV Lamp does not work 1 Check if the door is closed completely 2 Request for After Service A4 210X297 44 BIONEER Innovation Value Discovery ExiPrep 16 Dx Fully Automated Nucleic Acid Extraction System The Sample Block does not 1 Inspect the power supply maintain a cold temperature Verify the Sample Block status through the LCD screen or PC software Request service from your dealer The cooling fan does not function 1 Inspect the power supply Verify the Sample Block status through the LCD screen or PC software Request service from your dealer Protocol dose not update Check if the computer and the instrument are connected with LAN cable Restart the computer and instrument Update protocol Re update protocol The PC software does not 1 Inspect the network cables connecting the PC and network hub operate the instrument Inspect the network cables connecting the instruments and network hub 3 Verify that the network hub power
38. r Boe o vraiRWA Taman 6 30 vrelDNA RNA Dried biod spot Sa wara sa e an waonwena Soh o2 warna na e 32 wa NA RNA ar 2a vrai NA Censupemaan 6 38 vralDNA RNA A4 210X297 A0 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System No Target Samplesource No Target Sample source 7 01 Plasmid DNA endA strain 90o Protein HisTag 02 Plasmid DNA endA strain No Target Sample source EE Fragment DNA Gel slice 220 Fragment DNA PCR product 823 Fragment DNA Enzymatic reaction A4 210X297 41 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System X Troubleshooting The Power is not on Make sure the power connector is connected 2 Check if the system is connected to the adaptor 3 Check if the system power is pushed 4 If everything above has been followed but the power is not on contact After Service The Power is on but the system 1 Press the power button to block the power cannot initiate 2 Check if the power was turned off abnormally 3 When the system power was shut off abnormally check if there are any residues in tips and or accessories in the system 4 Remove any residues that may distract operating the system 5 Manually move the syringe block of the interior desktop in the center 6 Turn the power on and check w
39. r Enter tl selection menu A4 210X297 14 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System 3 RUN Not used PC Continued 7 Select the elution volume from the LCD touchscreen PREP SETUP complete PREP SETUP ine ee ea a 8 After selecting the desired elution volume press ok to a Open the instrument door and pull out the Base Plate CHECK LIST Place the Buffer Cartridge 2 Place the Buffer Cartridge 1 on the Base Plate according to the CHECK LIST 17 page on Place the Sample Tube Rack Place the Waste Tray Place the Elution Tube Rack 3 Place the Disposable Tip Rack Place all racks and Buffer Cartridges in their respective locations the LCD touchscreen Verify the name of the target nucleic acid type and sample Running Mode source type on the Running Mode screen and press the RUN GD WB F KTR button gt Progress of the extraction run can be checked through the RUN STOP PAUSE progress bar on the lower portion of the LCD touchscreen FEFPFFEFFFFFFFFFF 12 You may press the STOP button during the run to terminate the Running Mode extraction GD WB gt If you press STOP during an extraction run a popup Are vou sure prompt asking you whether you are sure Are you sure Yeo Ne will appear Select Yes to terminate the run or No to
40. rument automatically turns off the UV lamp and its operation when the instrument s door is open However just in case it does NOT turns off when the door is open please make sure the UV light does not directly expose to your eyes and skin 14 When there is liquid in the Waste Tray in the equipment take extra caution to push in or pull out the base plate so the liquid does NOT overflow to the instrument inside If the liquid overflows inside the instrument it may damage the instrument or cause the electrocution 6 UV Lamp 1 UV lamp operation may create Ozone molecules For the safety issue the instrument is pre programmed the UV lamp operation for 5 minutes only Please do NOT extensively use UV lamp operations 2 The Ultraviolet UV ray can seriously damage your eyes and skin when exposed directly even through indirectly When you deal with UV lamp make sure you are wearing proper protective equipment A4 210X297 m BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System lll System Components and Specifications 1 System Components ExiPrep 16 Dx Users Manual ExiPrep 16 Dx ie eT Disposable Tip Rack Elution Tube Rack Sample Tube Rack ig k 0 ExiPrep 16 Dx Accessory N N Multi Punch Option 6 Hole Punch Waste Tray Contamination Shield Protection Cab PCR Preparation Plate Elution Tube Rack Type for ExiStation Option Protecti
41. t is stopped either from operator error including improper accessory insertion or manually halting the instrument during normal operation you must re initialize the instrument before pulling out the Base Plate Pulling out the Base Plate without prior initialization can lead to instrument damage from movement interferences including a raised Heating Block or other accessories stopped in motion If Buffer Cartridges are inserted into the Base Plate please reinitialize the instrument or pull out the Buffer Cartridges to make sure the Heating Block is not in the way of normal Base Plate movement Avoid placing objects in the front and rear of the instrument as fan blockage may cause lowered efficiency of the Cooling Block Be careful not to have any obstructions or foreign materials introduced into the front lower side Cooling Fan mesh Foreign objects can hinder normal Cooling Fan operation and may lead to overheating of parts or cause a fire 2 Precautions regarding the operation environment If the power plug is loose do not use the instrument Plug overheating may result in shock or fire 2 Do not operate multiple instruments out of a single wall outlet The load may cause overheating and may lead to fire 3 When plugging or unplugging the power adapter cord from a wall outlet make sure your hands are A4 210X297 sp BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System completely
42. tection accessory Tip protector Contamination shield Detail can be found in page 11 Press the Store On button to turn the Cooling Block and cooling fan off A4 210X297 16 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System Xx Setup process according to the CHECK LIST Place the Buffer Cartridge on the heating block of the base plate gt If Buffer Cartridge is not properly placed on the heating block it may cause an experiment failure or an instrument malfunction 2 Place the Buffer Cartridge on the base plate gt Place the Buffer Cartridge by putting the cartridge to the left side of the base plate and press right hand side of the Cartridge to press the Cartridge to secure 3 Place the Sample tube rack on the base plate gt Be careful that the Sample tube rack s front and rear sides are properly placed 4 Place the Waste tray in between the Sample tube rack and the Buffer Cartridge Place the Elution tube rack on the base plate Check the Protection Cap is properly secured on the elution tube rack WARNING Be careful with the Aluminum sheet of the Protection Cap Place the Disposable tip rack on the base plate Push the Base plate all the way inside the instrument and close the door A4 210X297 17 BiONEER Innovation Value Discovery ExiPrep 16 Dx Fully Automated Nucleic Acid Extra
43. will release the tips immediately A4 210X297 27 BiONEER Innovation Value Discovery EviPrep 16 Dx Fully Automated Nucleic Acid Extraction System Vil ExiPrep 16 Dx Setup Continued 2 Registering a New User ExiPrep 16 Dx provides a user login option restricting the use of the instrument to registered users only Enabling the user login option will limit non user access to the instrument Do not forget your user ID if you have enabled the user login option MERIT Press the Setup button to access the SETUP menu UV lamp Store misc 5 OFF SET 9 ha SETUP 2 Press the User button to access the User Registration menu a oc OS User Config History User Registration l 1 screen and press Enter to save the ID fi i m id fall E gt Delete Delete last number entered T 7 GN a 5 gt Clear Delete all numbers entered 6 FI 9 9 FC gt Enter Save the numbers entered 3 Enter a 6 digit user ID using the keypad on the LCD touch O P m Delete Clear Enter K li ell Net User Registrati on 4 Verify the user ID and press ok to complete the registration gt Ifthe login option is enabled non registered use will have limited access to the instrument bH NH EA ST EH R gt Do not forget your user ID L X Up to 50 users can be registered You can manage non used user IDs using the administrator menu page 33 A4 210X297 28 BIONEER
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