CLUNIA® Clinical Zn-A gel CLUNIA® Maintenance Zn gel
Contents
1. Soukoulis S Hirsch R The effects of a tea tree oil containing gel on plaque and chronic gingivitis Aust Dent J 2004 Jun 49 2 78 83 Southern EN McCombs GB Tolle SL Marinak K The comparative effects of 0 12 chlorhexidine and herbal oral rinse on dental plaque induced gingivitis J Dent Hyg 2006 Winter 80 1 12 Sowinski J Petrone DM Wachs GN Chaknis P Kemp J Sprosta AA Devizio W Efficacy of three toothbrushes on established gingivitis and plaque Am J Dent 2008 Dec 21 6 339 45 Sreenivasan P Gaffar A Antiplaque biocides and bacterial resistance a review J Clin Periodontol 2002 Nov 29 11 965 74 Sreenivasan PK Furgang D Markowitz K McKiernan M Tischio Bereski D Devizio W Fine D Clinical anti micro bial efficacy of a new zinc citrate dentifrice Clin Oral Investig 2009 Jun 13 2 195 202 Stookey GK Warrick JM Miller LL et al Hexametaphosphate coated snack biscuits significantly reduce calculus formation in dogs J Vet Dent 1996 13 27 30 Stookey GK Warrick JM Miller LL Sodium hexametaphosphate reduces calculus formation in dogs Am J Vet Res 1995 56 913 8 Studer E Stapley RB The role of dry foods in maintaining healthy teeth and gums in the cat Vet Med Small Anim Clin 1973 Oct 68 10 1124 6 Suresh DK Vandana KL Mehta DS Intracrevicular application of 0 3 Flurbiprofen gel and 0 3 Triclosan gel as anti inflammatory agent A comparative clinical study Indian J Dent Res 2001 Apr Jun2. de Alta Eficacia y Seguridad en Perros Gatos Ex ticos y Caballos La enfermedad periodontal es posiblemente la patolog a m s com n en perros y gatos Lund EM y col 1999 Maretta SM 1994 Se ha reportado una incidencia del 60 en gatos dom sti cos de m s de 3 a os de edad y hasta el 85 en gatos mayores de 6 a os Maretta SM 1994 Tholen M y Hoyt RF 1990 en perros se han reportado cifras similares La enfermedad periodontal es una enfermedad cr nica e irrever sible que afecta al tejido de sost n de los dientes enc as hueso alveolar cemento radicular y ligamento periodontal La enferme dad periodontal a menudo se divide en dos condiciones la gingivitis y la periodontitis La gingivitis es la inflamaci n de la Pon enc a mientras que la periodontitis es la inflamaci n de los Siram aon tejidos no gingivales el ligamento periodontal y el hueso alveolar Harvey CE 2005 Composici n Clinical Zn A gel Maintenance Zn gel Gluconato de Zinc 2 2 cido asc rbico 1 6 Taurina 1 0 5 Excipientes csp csp Mecanismo de acci n e CLUNIA restaura el microambiente de la boca y enc as creando un entorno que favorece su curaci n natural Contiene un complejo formado por Gluconato de Zinc Vitamina C y Taurina que proporciona Zinc altamente biodisponible a las capas m s profundas de la mucosa oral El Zinc es un factor esencial en m s de 300 reacciones enzim ticas muchas de las cuales interviene
3. as y acorta el tiempo de la intervenci n Al igual que los antibi ticos aplicados profil cticamente tras una cirug a la acci n antis ptica de CLUNIAS Clinical Zn A gel ayuda a prevenir infecciones tras la limpieza dental VetNova T 34 918 440 273 vetnova vetnova net www vetnova net Gel Oral Mucoadhesivo de F cil Aplicaci n para una Higiene Buco Dental Caracter sticas Protecci n completa placa sarro gingivitis estomatitis y halitosis Reduce la formaci n de placa Acci n antis ptica frente a pat genos periodontales Favorece la resoluci n de la gingivitis Estimula la cicatrizaci n de enc as y mucosas lesionadas o ulceradas Neutraliza r pidamente 30 segundos el mal aliento Natural Zinc Vitamina C y Taurina y muy seguro Ideal para tratamientos prolongados en los que el animal ingiere el producto Sin sabor Alta aceptaci n F cil aplicaci n sin necesidad de cepillado Una f rmula avanzada para uso terap utico CLUNIA Clinical Zn A gel y otra de m xima aceptaci n por la mascota para uso profil ctico CLUNIA Maintenance Zn gel No mancha el esmalte dental VN PUB 0090ES Gel Oral Mucoadhesivo de Facil Aplicacion para una Higiene Buco Dental de Alta Eficacia y Seguridad en Perros Gatos Ex ticos y Caballos Y Problemas periodontales avanzados Y Post cirugia oral o maxilofacial v Heridas y laceraciones bucales Y lceras orales v Absces
4. B Blake MI Plaque prevention suspension theory and ascorbic acid and urea J Pharm Sci 1978 May 67 5 IV Fedi PF Etiology of periodontal disease In The periodontic syllabus Philadelphia Lea amp Febiger 1985 p 13 8 e Flotra L Johansen JR Gjermo P he effect of Ascoxal T on experimental gingivitis and plaque formation J Periodontal Res 1969 4 2 171 Forcella BA A rationale for the use of antimicrobials in prevention and treatment of periodontal disease Bull Ninth Dist Dent Soc 1988 Mar 72 1 18 21 Freeman LM Michel KE Evaluation of raw food diets for dogs J Am Vet Med Assoc 2001 218 705 9 1716 Frentzen M Ploenes K Braun A Clinical and microbiological effects of local chlorhexidine applications Int Dent J 2002 Oct 52 5 325 9 Gad T Periodontal disease in dogs J Periodont Res 1968 3 268 72 Gaffar A Solis Gaffar MC Tavss E Marcussen HW Rustogi KN Long term antiplaque anticalculus and antigingi vitis effects of benzethonium polymer complex in beagle dogs J Dent Res 1981 Nov 60 11 1897 1903 Genco RJ Pathogenesis and host responses in periodontal disease In Genco RJ Goldman HM Cohen DW editors Contemporary periodontics St Louis MO CV Mosby 1990 p 184 93 e Gengler W A study to assess efficacy of a prophylactic dental product in dogs Proceedings of the 18th Veterinary Dental Forum 2004 152 Gengler WR Kunkle BN Romano D Larsen D Evaluation of a barrier dental sealant i
5. J Clin Periodontol 2003 Sep 30 9 773 7 Cleland WP Jr Opportunities and obstacles in veterinary dental drug delivery Adv Drug Deliv Rev 2001 Sep 1 50 3 261 75 Cohen DW editors Contemporary periodontics St Louis MO CV Mosby 1990 p 3 32 Cohen M A new era in halitosis and periodontal treatment Dent Today 1998 Aug 17 8 88 9 VetNova T 34 918 440 273 vetnova vetnova net www vetnova net a y FICHA TECNIGA VN PUB 0090ES Gel Oral Mucoadhesivo de Facil Aplicacion para una Higiene Buco Dental de Alta Eficacia y Seguridad en Perros Gatos Ex ticos y Caballos Colyer F Dental disease in animals Br Dent J 1947 82 31 5 e Colyer F Variation in number size and shape In Miles AEW Grigson C editors Variations and diseases of the teeth of animals New York Cambridge University Press 1990 p 62 4 Coria Avila GA Gonz lez Hern ndez JL Rosales Raya JB Aguirre Manzo ML Cibrian Llanderal T Herrera Cova rrubias D Espin Iturbe LT Manzo J Halitosis and weight loss in a cat Lab Anim NY 2010 Jun 39 6 169 70 172 3 Cronin MJ Dembling WZ Cugini M Thompson MC Warren PR A 30 day clinical comparison of a novel interdental cleaning device and dental floss in the reduction of plaque and gingivitis J Clin Dent 2005 16 2 33 7 e Cupp CJ Gerheart LA Pinnick DV et al Reduction of plaque and tartar accumulation in cats and its role in a feline dental health program In Friskies pro
6. SofScale Calculus Scaling Gel in dogs and cats J Vet Dent 1994 Mar 11 1 9 13 Williams CA Aller MS Gingivitis stomatitis in cats Vet Clin North Am Small Anim Pract 1992 Nov 22 6 1361 83 Wilson TG Jr How patient compliance to suggested oral hygiene and maintenance affect periodontal therapy Dent Clin North Am 1998 42 2 389 403 Winkel EG Roldan S Van Winkelhoff AJ Herrera D Sanz M Clinical effects of a new mouthrinse containing chlorhexidine cetylpyridinium chloride and zinc lactate on oral halitosis A dual center double blind placebo contro lled study J Clin Periodontol 2003 Apr 30 4 300 6 e Winston JL Bartizek RD McClanahan SF Mau MS Beiswanger BB A clinical methods study of the effects of triclosan dentifrices on gingivitis over six months J Clin Dent 2002 13 6 240 8 Witt J Ramji N Gibb R Dunavent J Flood J Barnes J Antibacterial and antiplaque effects of a novel alcohol free oral rinse with cetylpyridinium chloride J Contemp Dent Pract 2005 Feb 15 6 1 1 9 VetNova T 34 918 440 273 vetnova vetnova net www vetnova net St VN PUB 0090ES CLUNIA Clinical Zn A gel CLUNIA Maintenance Zn gel Gel Oral Mucoadhesivo de F cil Aplicaci n para una Higiene Buco Dental de Alta Eficacia y Seguridad en Perros Gatos Ex ticos y Caballos Witzenberger T O Leary TJ Gillette WB Effect of a local germicide on the occurrence of bacteremia during subgingival scaling J Periodo
7. el color cambiar de verde a marr n amarillo Presentaci n e CLUNIA Clinical Zn A gel 118 ml CLUNIA Maintenance Zn gel 59 ml Bibliogr fia Adams SE Theobald AJ Jones NM Brading MG Cox TF Mendez A Chesters DM Gillam DG Hall C Holt J The effect of a toothpaste containing 2 zinc citrate and 0 3 Triclosan on bacterial viability and plaque growth in vivo compared to a toothpaste containing 0 3 Triclosan and 2 copolymer Int Dent J 2003 Dec 53 6 Suppl 1 398 403 Albert Kiszely A Pjetursson BE Salvi GE Witt J Hamilton A Persson GR Lang NP Comparison of the effects of cetylpyridinium chloride with an essential oil mouth rinse on dental plaque and gingivitis a six month randomized controlled clinical trial J Clin Periodontol 2007 Aug 34 8 658 67 American Animal Hospital Association The path to high quality care Lakewood CO American Animal Hospital Association 2003 Ammons WF Harrington GW The periodontic endodontic continuum In Newman MG Takei HH Carranza FA eds Clinical periodontology 9th ed Philadelphia WB Saunders 2002 840 850 Anonymous Guidance on the assessment of the efficacy of toothpastes FDI Commission Work Project 8 95 Int Dent J 1999 Dec 49 6 311 6 Asokan S Emmadi P Chamundeswari R Effect of oil pulling on plaque induced gingivitis a randomized controlled triple blind study Indian J Dent Res 2009 Jan Mar 20 1 47 51 Association of American Feed Co
8. n para una Higiene Buco Dental de Alta Eficacia y Seguridad en Perros Gatos Ex ticos y Caballos Sekino S Ramberg P Uzel NG Socransky S Lindhe J The effect of a chlorhexidine regimen on de novo plaque formation J Clin Periodontol 2004 Aug 31 8 609 14 Sgan Cohen HD Vered Y A clinical trial of the meridol toothbrush with conical filaments evaluation of clinical effectiveness and subjective satisfaction J Clin Dent 2005 16 4 109 13 Sgan Cohen HD Vered Y Plaque removal and oral health promotion potential for the elmex interX medium toothbrush clinical efficacy and safety evaluation J Clin Dent 2003 14 3 70 3 Shapira L Shapira M Tandlich M Gedalia Effect of amine fluoride stannous fluoride containing toothpaste Meridol on plaque and gingivitis in adults a six month clinical study J Int Acad Periodontol 1999 Oct 1 4 117 20 Sharma N Charles CH Lynch MC Qaqish J McGuire JA Galustians JG Kumar LD Adjunctive benefit of an essential oil containing mouthrinse in reducing plaque and gingivitis in patients who brush and floss regularly a six month study J Am Dent Assoc 2004 Apr 135 4 496 504 Sharma NC Galustians HJ Qaqish J Charles CH Vincent JW McGuire JA Antiplaque and antigingivitis effective ness of a hexetidine mouthwash J Clin Periodontol 2003 Jul 30 7 590 4 Shearer B Hall P Clarke P Marshall G Kinane DF Reducing variability and choosing ideal subjects for experimen tal gingiviti
9. 12 2 105 12 Svanberg G Lindhe J Hugoson A et al Effect of nutritional hyperparathyroidism on experimental periodontitis in the dog Scand J Dent Res 1973 81 155 62 Talbot E Interstitial gingivitis or so called pyorrhoea alveolaris Philadelphia SS White Tannock GW Webster JR Dobbinson SS Feline gingivitis N Z Vet J 1988 Jun 36 2 93 4 VetNova T 34 918 440 273 vetnova vetnova net www vetnova net VN PUB 0090ES Gel Oral Mucoadhesivo de F cil Aplicaci n para una Higiene Buco Dental de Alta Eficacia y Seguridad en Perros Gatos Ex ticos y Caballos Tepe JH Leonard GJ Singer RE et al The long term effect of chlorhexidine on plaque gingivitis sulcul depth gingival recession and loss of attachment in beagle dogs J Peridontal Res 1983 18 452 8 Terranova VP Goldman HM Listgarten MA The periodontal attachment apparatus In Genco RJ Goldman HM Cohen DW editors Contemporary periodontics St Louis MO CV Mosby 1990 p 33 54 Theyse LFH Drieling HE Dijkshoorn NA et al A comparative study of 4 dental home care regiments in client owned cats In Debraekeleer J Meyer H editors Proceedings of the Hill s European Symposium on Oral Care Watford UK 2003 p 60 3 Tholen M Hoyt RF Oral pathology In Bojrab MJ Tholen M eds Small animal oral medicine and surgery Philadel phia Lea amp Febiger 1990 42 Tipton DA Flynn JC Stein SH et al Cyclooxygenase 2 inhibitors decrease
10. 13 Summer 30 2 84 7 Rassameemasmaung S Sirikulsathean A Amornchat C Hirunrat K Rojanapanthu P Gritsanapan W Effects of herbal mouthwash containing the pericarp extract of Garcinia mangostana L on halitosis plaque and papillary bleeding index J Int Acad Periodontol 2007 Jan 9 1 19 25 e Rathe F Auschill TM Sculean A Gaudszuhn Ch Arweiler NB The plaque and gingivitis reducing effect of a chlorhexidine and aluminium lactate containing dentifrice Lacalut aktiv over a period of 6 months J Clin Periodon tol 2007 Aug 34 8 646 51 e Rawlings JM Gorrel C Markwell PJ Effect on canine oral health of adding chlorhexidine to a dental hygiene chew J Vet Dent 1998 15 3 129 34 e Rawlings JM Gorrel C Markwell PJ Effect of two dietary regimens on gingivitis in the dog J Small Anim Pract 1997 Apr 38 4 147 51 e Reichart PA Durr UM Triadan H et al Periodontal disease in the domestic cat J Periodont Res 1984 19 67 75 Reiter AM Brady CA Harvey CE Local and systemic complications in a cat after poorlyperformed dental extractions J Vet Dent 2004 21 215 221 Ribeiro DG Pavarina AC Giampaolo ET Machado AL Jorge JH Garcia PP Ribeiro DG Pavarina AC Giampaolo ET Machado AL Jorge JH Garcia PP Effect of oral hygiene education and motivation on removable partial denture wearers longitudinal study Gerodontology 2009 Jun 26 2 150 6 Ritchey TW Lamster IB Mann PH Alfano MC The effect of zinc chloride on the dev
11. 4 e Hennet P Effectiveness of an enzymatic rawhide dental chew to reduce plaque in beagle dogs J Vet Dent 2001 Jun 18 2 61 4 Hennet P Review of studies assessing plaque accumulation and gingival inflammation in dogs J Vet Dent 1999 Mar 16 1 23 9 Hennet PR Delille B Davot JL Oral malodor measurements on a tooth surface of dogs with gingivitis Am J Vet Res 1998 Mar 59 3 255 7 e Henrikson PA Periodontal disease and calcium deficiency An experimental study in the dog Acta Odontol Scand 1968 26 Suppl 50 1 132 Hernandez Cott PL Elias Boneta A Stewart B DeVizio W Proskin HM Clinical investigation of the efficacy of a commercial mouthrinse containing 0 05 cetylpyridinium chloride in reducing dental plaque J Clin Dent VetNova T 34 918 440 273 vetnova vetnova net www vetnova net VN PUB 0090ES Gel Oral Mucoadhesivo de F cil Aplicaci n para una Higiene Buco Dental de Alta Eficacia y Seguridad en Perros Gatos Ex ticos y Caballos 2009 20 2 39 44 Hoffman TH Gaengler P Epidemiology of periodontal disease in poodles J Small Anim Pract 1996 37 309 16 Holmstrom SE Bellows J Juriga S Knutson K Niemiec BA Perrone J 2013 AAHA Dental Care Guidelines for Dogs and Cats JAAHA 2013 Mar Apr Holmstrom SE Frost P Eisner ER Periodontal therapy and surgery In Holmstrom SE Frost P Eisner ER eds Veterinary dental techniques 3rd ed Philadelphia WB Saunders 2004 233 290 Howell TH Fiorellini
12. 6 Sep 11 Nachnani S The effects of oral rinses on halitosis J Calif Dent Assoc 1997 Feb 25 2 145 50 Navia JM Experimental oral calculus In Animal models in dental research Tuscaloosa AL University of Alabama Press 1977 p 298 311 Neiva RF Steigenga J Al Shammari KF et al Effects of specific nutrients on periodontal disease onset progression and treatment J Clin Peridontol 2003 30 579 89 Newman MG Takei HH Carranza FA Clinical periodontology 9th ed Philadelphia WB Saunders 2002 354 370 Norris JM Love DN In vitro antimicrobial susceptibilities of three Porphyromonas spp and in vivo responses in the oral cavity of cats to selected antimicrobial agents Aust Vet J 2000 78 533 537 Nossek H Chemoprevention of gingivitis Stomatol DDR 1984 Oct 34 10 660 4 Ogaard B Alm AA Larsson E Adolfsson U A prospective randomized clinical study on the effects of an amine fluoride stannous fluoride toothpaste mouthrinse on plaque gingivitis and initial caries lesion development in orthodontic patients Eur J Orthod 2006 Feb 28 1 8 12 Ozaki F Pannuti CM Imbronito AV Pessotti W Saraiva L de Freitas NM Ferrari G Cabral VN Efficacy of a herbal toothpaste on patients with established gingivitis a randomized controlled trial Braz Oral Res 2006 Apr Jun 20 2 172 7 Page RC The role of inflammatory mediators in the pathogenesis of periodontal disease J Periodontal Res 1991 26 230 242 Page R
13. C Schroeder HE Spontaneous chronic periodontitis in adult dogs J Periodontol 1979 52 60 73 Paquette DW Simpson DM Friden P Braman V Williams RC Safety and clinical effects of topical histatin gels in humans with experimental gingivitis J Clin Periodontol 2002 Dec 29 12 1051 8 e Pedersen NC Inflammatory oral cavity diseases of the cat Vet Clin North Am Small Anim Pract 1992 Nov 22 6 1323 45 Perry DA Plaque control for the periodontal patient In Newman MG Takei HH Carranza FA eds Clinical periodontology 9th ed Philadelphia WB Saunders 2002 651 674 e Peter S Nayak DG Philip P Bijlani NS Antiplaque and antigingivitis efficacy of toothpastes containing Triclosan and fluoride Int Dent J 2004 54 5 Suppl 1 299 303 VetNova T 34 918 440 273 vetnova vetnova net www vetnova net Ficha T cnica VN PUB 0090ES Gel Oral Mucoadhesivo de F cil Aplicaci n para una Higiene Buco Dental de Alta Eficacia y Seguridad en Perros Gatos Ex ticos y Caballos e Petrova E Nachev Ch Aleksiev N Zinc aspartate treatment of pneumoconiosis Med Tr Prom Ekol 1997 10 33 6 Putt MS Milleman JL Davidson KR Kleber CJ Cugini M A split mouth comparison of a three dimensional action electric toothbrush and a high frequency electric toothbrush for reducing plaque and gingivitis J Int Acad Periodon tol 2001 Oct 3 4 95 103 Quest BW Oral health benefits of a daily dental chew in dogs J Vet Dent 20
14. C y Taurina y generalmente reconocidos como el enfoque m s seguro para el cuidado oral especialmente en animales que a diferencia de las personas ingieren todo el producto No tienen contraindicaciones por tanto pueden ser administrados a largo plazo o de por vida La vitamina C estimula la salivaci n por lo que algunos gatos pueden presentar sialorrea tras la adminis traci n de CLUNIA Clinical Zn A gel CLUNIA Maintenance Zn gel al carecer de vitamina C puede ser una mejor opci n para esos gatos Advertencias Guarde el envase bien cerrado en un lugar fresco seco protegido de la luz solar y fuera del alcance de los ni os y los animales Despu s de mezclar la vitamina C CLUNIA Clinical Zn A gel tiene una vida til de aproximadamente 6 meses en un armario fresco y oscuro o 1 a o en el refrigerador El color de la soluci n indica el grado de frescura y eficacia del producto util celo mientras se mantenga azul o verde un color marr n o amarillo denota que el producto aunque seguro ya no es fresco y eficaz Qu causa el cambio de color La vitamina C es inestable en soluciones acuosas como el gel de metilcelulosa en la f rmula de CLUNIA Una vez que se mezcla la vitamina C cido asc rbico cambia muy lentamente a dehidro asc rbico que es de color amarillo cuando el amarillo se mezcla con el azul de gel de CLUNIA se proyecta un color verde cuando la concentraci n de cido dehidro asc rbico es muy alta
15. J Weber HP Williams RC Effect of the NSAID piroxicam topically administered on the development of gingivitis in beagle dogs J Periodontal Res 1991 May 26 3 Pt 1 180 3 Howell TH Reddy MS Weber HP Li KL Alfano MC Vogel R Tanner AC Williams RC Sulfadiazines prevent plaque formation and gingivitis in beagles J Periodontal Res 1990 Jul 25 4 197 200 Hu D Zhang YP DeVizio W Proskin HM A clinical investigation of the efficacy of two dentifrices for controlling oral malodor and plaque microflora overnight J Clin Dent 2008 19 3 106 10 Hugoson A Lundgren D Asklow B Borgklint G Effect of three different dental health preventive programmes on young adult individuals a randomized blinded parallel group controlled evaluation of oral hygiene behaviour on plaque and gingivitis J Clin Periodontol 2007 May 34 5 407 15 Hull PS Davis RM The effect of a chlorhexidine gel on tooth deposits in beagle dogs J Small Anim Pract 1972 13 207 12 gi M Mihailovi D Kesi L Apostolovi M Kostadinovi L Janji OT Milasin J Efficacy of hyaluronic acid in the treatment of chronic gingivitis in children Vojnosanit Pregl 2011 Dec 68 12 1021 5 ngham K Effect of a dental chew on dental substrates and gingivitis in cats J Vet Dent 2003 Sep 20 3 136 ngham KE Gorrel C Bierer TL Effect of a dental chew on dental substrates and gingivitis in cats J Vet Dent 2002 Dec 19 4 201 4 Erratum in J Vet Dent 2003 Sep 20 3 136 ng
16. Long term effects of chlorhexidine on developing gingivitis in the beagle dog J Peridont Res 1973 8 63 70 Hamp SV Lindberg R Histopathology of spontaneous periodontitis in dogs J Periodont Res 1971 6 266 77 Hamp SV Viklands P Farso Madsen K et al Prevalence of periodontal disease in dogs J Dent Res 1975 SIA 19 e Harvey CE Management of periodontal disease understanding the options Vet Clin North Am Small Anim Pract 2005 35 4 819 36 e Harvey CE Shofer FS Laster L Correlation of diet other chewing activities and periodontal disease in North American client owned dogs J Vet Dent 1996 3 101 5 e Harvey CE Thornsberry C Miller BR Subgingival bacteria comparison of culture results in dogs and cats with gingivitis J Vet Dent 1995 Dec 12 4 147 50 e Harvey CE Establishment of a veterinary oral health center proposed to AVMA J Vet Dent 1995 12 115 7 e Harvey CE Emily PP Periodontal disease In Ladig D editor Small animal dentistry St Louis MO Mosby Year Book 1993 p 89 144 e Harvey CE Function and formation of the oral cavity In Veterinary dentistry Philadelphia WB Saunders 1985 p 5 22 Hefferren JJ Schiff TG Smith MR Assessment methods and clinical outcomes chemical and microbial composi tion formation and maturation dynamics of pellicle plaque and calculus J Vet Dent 1994 Aug 11 2 75 9 Hennet P Effectiveness of a dental gel to reduce plaque in beagle dogs J Vet Dent 2002 19 11
17. al findings on whole saliva and plaque Acta Odontol Scand 1975 33 129 71 Mallonee DH Harvey CE Venner M et al Bacteriology of periodontal disease in the cat ArchOral Biol 1988 33 677 683 VetNova T 34 918 440 273 vetnova vetnova net www vetnova net VN PUB 0090ES Gel Oral Mucoadhesivo de F cil Aplicaci n para una Higiene Buco Dental de Alta Eficacia y Seguridad en Perros Gatos Ex ticos y Caballos Manfra Marretta S Recognition of feline oral lesions Proceedings of the Atlantic Coast Veterinary Conference 2001 e Mankodi S Bauroth K Witt JJ Bsoul S He T Gibb R Dunavent J Hamilton A A 6 month clinical trial to study the effects of a cetylpyridinium chloride mouthrinse on gingivitis and plaque Am J Dent 2005 Jul 18 Spec No 9A 14A Mankodi S Lopez M Smith Petrone DM Petrone ME Chaknis P Proskin HM Comparison of two dentifrices with respect to efficacy for the control of plaque and gingivitis and with respect to extrinsic tooth staining a six month clinical study on adults J Clin Dent 2002 13 6 228 33 Maretta SM Current concepts in canine and feline dentistry In Kirk RW Bonagura JD eds Current veterinary therapy XII Philadelphia WB Saunders 1994 685 691 Mateu FA Boneta AE DeVizio W Stewart B Proskin HM A clinical investigation of the efficacy of two dentifrices for controlling established supragingival plaque and gingivitis J Clin Dent 2008 19 3 85 94 McClanaha
18. ca en las enc as superiores la acci n de limpieza natural de la boca distribuir el gel a sus reas m s remotas 3 Repita la aplicaci n cada d a para una m xima eficacia 4 La mayor a de los perros de razas medianas y grandes aceptar n la aplicaci n directa de la punta del aplicador incorporado en gatos y perros de razas peque as para maximizar la aceptaci n deposite una gota en el dedo ndice bastoncillo o cepillo dental y apliquela en las enc as CLUNIA Maintenance Zn gel siga los pasos 2 a 4 arriba descritos Seguridad Muchos productos dentales de uso dom stico contienen clorhexidina Investigaciones publicadas han demostrado que el uso regular de clorhexidina en odontolog a veterinaria puede aumentar la tasa de mineralizaci n de la placa formaci n de c lculos manchar el esmalte dental marr n y disminuir el sentido del gusto del paciente Hale FA 2002 Adem s por su acci n antimicrobiana al ser ingerido destruye parcialmente la flora digestiva VetNova T 34 918 440 273 vetnova vetnova net www vetnova net No mancha superficies del hogar y tejidos Bajo coste diario Disponible exclusivamente a trav s de veterinarios VN Fub 0090ES Gel Oral Mucoadhesivo de F cil Aplicaci n para una Higiene Buco Dental de Alta Eficacia y Seguridad en Perros Gatos Ex ticos y Caballos CLUNIA Clinical Zn A gel y CLUNIA Maintenance Zn gel son productos naturales Zinc Vitamina
19. ckson JF editors Modern nutrition Boca Raton FL CRC Press 1995 p 119 26 Beck JD Arbes Jr SJ Epidemiology of gingival and periodontal diseases In Newman MG Takei HH Carranza FA eds Clinical periodontology 9th ed Philadelphia WB Saunders 2002 74 94 e Beck JD Offenbacher S The association between periodontal diseases and cardiovascular diseases a state of the science review Ann Periodontol 2001 6 1 9 15 Becks H Wainwright WW Morgan AF Comparative study of oral changes in dogs due to deficiencies of pantothenic acid nicotinic acid and an unknown of the B vitamin complex Am J Orthodontol Oral Surg 1943 29 183 207 Becks H Weber M The influence of diet on the bone system with special reference to the alveolar process and labyrinthine capsule J Am Dent Assoc 1931 18 197 264 Bell AF Dental disease in the dog J Small Anim Pract 1965 6 421 8 Bellows J Carithers DS Gross SJ Efficacy of a barrier gel for reducing the development of plaque calculus and gingivitis in cats J Vet Dent 2012 Summer 29 2 89 94 Erratum in J Vet Dent 2012 Autumn 29 3 196 Bellows J Small animal dental equipment materials and techniques 1st ed Ames IA Blackwell 2004 Bellows J Interpreting dental radiographs for periodontal disease DVM News magazine July 1 2001 Biesbrock AR Bartizek RD Gerlach RW Ter zhalmy GT Oral hygiene regimens plaque control and gingival health a two month clinical trial with a
20. ctiveness of feeding large kibbles with mechanical cleaning properties in cats with gingivitis Tijdschr Diergeneeskd 2005 Mar 1 130 5 136 40 Dutch e Wara aswapati N Krongnawakul D Jiraviboon D Adulyanon S Karimbux N Pitiphat W The effect of a new toothpaste containing potassium nitrate and triclosan on gingival health plaque formation and dentine hypersensiti vity J Clin Periodontol 2005 Jan 32 1 53 8 Warrick JM Stookey GK Overview of clinical trials using sodium hexametaphosphate for the prevention of dental calculus Proceedings of the 18th Veterinary Dental Forum 2004 272 276 Warrick JM Stookey GK Inskeep GA et al Reducing calculus accumulation in dogs using an innovative rawhide treat system coated with hexametaphosphate In Proceedings of the 15th Veterinary Dental Forum 2001 p 379 82 e Warrick JM Inskeep GA Yonkers TD Stookey GK Ewing TH Effect of clindamycin hydrochloride on oral malodor plaque calculus and gingivitis in dogs with periodontitis Vet Ther 2000 Winter 1 1 5 16 Watson ADJ Diet and periodontal disease in dogs and cats Aust Vet J 1994 71 313 8 e White DJ Gerlach RW Anticalculus effects of a novel dual phase polyphosphate dentifrice chemical basis mechanism and clinical response J Contemp Dent Pract 2000 1 1 19 Wiggs RB Lobprise HB Veterinary dentistry principles amp practice Philadelphia LippincottRaven 1997 Wiggs RB Lobprise HB Tholen MA Clinical evaluation of
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28. n en la regeneraci n de la matriz extra celular los procesos de cicatrizaci n la reparaci n del tejido conectivo la inflamaci n y el crecimiento celular En la cavidad oral el Zinc debido a su papel en la producci n de col geno permite la recuperaci n del tejido gingival de una forma eficaz disminuyendo la inflamaci n e La Taurina tiene acci n quelante sobre compuestos de azufre que producen el mal aliento y oxida los cidos grasos vol tiles en la boca reduciendo r pidamente a partir de 30 segundos la halitosis e La Vitamina C cido asc rbico es importante para la producci n de col geno que es la principal prote na estructural en la enc a Estimula la reparaci n del tejido gingival y acelera su reparaci n Adem s el ascorbato de zinc estimula las gl ndulas salivales proporcionando una acci n de lavado en toda la cavidad oral que facilita la difusi n del gel por todos los rincones de la boca La Carboximetilcelulosa es muco adhesiva y proporciona un mayor tiempo de contacto del producto con las superficies de la cavidad oral Gurny R Meyer JM Peppas NA 2015 Indicaciones Perros y gatos CLUNIA Clinical Zn A gel Uso Terap utico Y Antes y despu s de una revisi n y o higiene bucodental e Aplicado a diario durante los 7 10 d as previos a una limpieza dental particularmente en animales con gingivitis CLUNIA Clinical Zn A gel reduce significativamente la hemorragia al mejorar la salud de las enc
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37. os Y Mantiene en ptimas condiciones al estimular la salivaci n la cavidad oral en pacien tes intubados sedados y post quir rgicos CLUNIA Maintenance Zn gel Uso Profil ctico y o de Mantenimiento Y Aplicado a diario ayuda a mantener una salud oral ptima asegurando la capacidad de la masco ta de seguir una correcta alimentaci n durante toda la vida previniendo problemas m s graves como la endocarditis bacteriana y contribuyendo a mejorar el bienestar del animal Y Para limpiar y refrescar la cavidad oral y los dientes con o sin cepillar Y Control de halitosis Ex ticos Conejos Problemas dentales asociados a sobrecrecimiento y maloclusi n dental lceras abscesos Hurones Enfermedad periodontal Reptiles Estomatitis Aves Sinusitis leves o intermedias Caballos Heridas producidas por el bocado Heridas cicatrizes post extracci n dental Lesiones orales Abscesos Irritaciones post limado dental Periodontitis Estomatitis Modo de Empleo e CLUNIA Clinical Zn A gel 1 Desenrosque el tap n aplicador vierta el contenido del vial adjunto vitamina C en la botella y permita que la vitamina C se deposite en el fondo de la botella Coloque el tap n y agite hasta que se disuelva 2 Aplique 1 gota del tama o de un guisante aproximadamente 0 5 ml para mascotas de hasta 10 kg aumente la dosis para perros medianos grandes y caballos de gel en cada lado de la bo
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