スリー・ディー・マトリックス（7777）
Contents
1. 1992 MM Zhang2. SR Inc
3. 2015 4 20 2015 4 2015 4 97 51 1 918 1 984 1 814 1 884
4. SR Weaknesses
5. 2014 6 4 TDM 621 3 D Matrix Asia Pte Ltd ITDM 621 2014 6 3 CE
6. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7
7. MIT Shuguang Zhang 2014 11 2014 11 27 ReproHepato PuraMatrix PuraMatrix iPS ReproHepato
8. TDM 621 4 Gerrmany France UK EU Italy Spain Switzerland Austria Hong Kong New Zealand Singapore Indonesia CE Korea tm Taiwan Australia Brazil Mexico Columbia CE Ja pa n http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7
9. pH TDM 621
10. Shared lesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 2014 10 FDA 510 k 2015 1 510 k 510k
11. 5 3
12. 2014 9 9 TDM 641 TDM 641 2014 9 9 PMDA TDM 641 3
13. SR
14. 2 sSh ared 1 ch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report
15. DDS Sh ared 1 ch lp http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7
16. pH bFGF PDGF PuraMatrix R A D 16 RADA16 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7
17. Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 582 675 266 316 409
18. TDM 511 2014 4 2014 2 2014 2 13 3
19. 3 III 1 I 2 II 3 1 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved sSh ared lesearch p http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 Lo i ERE ro
20. Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7
21. PuraStat Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 CE PuraStat 3 D Matrix Asia Pte Ltd 2014 6
22. TDM 621 2014 1 CE CE TDM 621 CE TDM 621 3 D Matrix Asia Pte Ltd 2014 6 2014 9 3
23. lesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 99799 sSh ared 7777 SR Research Report 2015 7 DDS Drug Delivery System
24. Shared Gxcscarch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 TDM 621 TR A TDM 621 TDM 621 TDM 621 3 2 TDM 621
25. C TDM 641 2012 2 20 Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 2014 9 3 PuraStat
26. CRO PII II 1 2 3
27. CE 2015 3 FDA 2016 4 2014 12 7 2 1 50 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7
28. 2 3 2014 1 2014 1 31 3 D Matrix Inc MIT B Bridge International B Bridge 3 D Matr
29. http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 201577 7 Massachusetts Institute of Technology MIT Shuguang Zhang 2004 5 1992 MIT Shuguang Zhang MIT MIT 2001 5 3 D Matrix Inc
30. MBA http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 1999 ASDAQ 7774 2002 2370 COO 2003 10 2005 2007 1998
31. Exploit Technologies Pte Ltd A STAR 2014 5 DDS 2014 12 2014 12 22 PuraStat 2014 1 14 PuraStat CE 2014 12 27 2014 12 22 Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Researc
32. MITT MIT 2014
33. 2009 4 1 8001 Daewoong Pharmaceutical Co LTD Excelsior Medical Co Ltd PT Teguhsindo Lestaritama TDM 641 Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7
34. RPN 2 A6K siRNA DDS NEDO NEDO 2010 2015 4 3
35. 2015 4 2017 4 Sh ared lesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 2015 3 9 PuraStat
36. 2017 4 TDM 621 2017 4 CE lo EU RM 3 976
37. 2013 5 3 D Matrix Asia Pte Ltd PT Tegushindo Lestaritama TDM 711 15 FDA Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 TDM 641 PMDA RPN 2 2011 Phase I
38. 2014 7 TDM 621 2014 6 PMDA FDA TDM 711 FDA TDM 641 2014 9 PMDA 2015 3 2 3
39. 2016 4 PT Teguhsindo Lestaritama PT Teguhsindo Lestaritama 50 2015 4 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved sSh ared lesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 2015 4 15
40. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 170 TDM 621
41. 2004 5 2004 10 3 DMatrix Inc LICENSE AND SUPPLY AGREEMENT 3 D Matrix Inc MIT MIT Scientific Founders 2007 10 3 D Matrix Inc 1992 MIT Shuguang Zhang 2001 5 MIT 3 D Matrix Inc 2003 4 3 D Matrix Inc MIT Exclusive Patent License Agreement 2004 5
42. 2004 10 3 D Matrix Inc LICENSE AND SUPPLY AGREEMENT 3 D Matrix Inc PuraMatrix 2007 10 3 D Matrix Inc 2008 2 Becton Dickinson and Company SUPPLY AGREEMENT PuraMatrix RADA16 2008 3 Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved sSh ared esearch 7777 2008 10 2009 4 2009 7 2009 8 2010 1 2010 8 2010 9 2011 5 2011 7 2012 2 2012 3 2012 4 2012
43. CE TDM 621 2011 5 1 4538 10 Daewoong Pharmaceutical Co LTD Excelsior Medical Co Ltd
44. NEDO 2010 2013 4 2013 6 13 2013 4 32 977 978 2013 4 19 TDM 621 PMDA
45. 2 4 2015 4 100 107
46. 2018 4 751 TDM 621 2014 1 14 CE 2015 4 o 2016 4 2015 3 2014 9 2015 4 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved
47. 2 800 2014 8 2018 4 200 2014 11 2016 4 800 2015 4 A 1 600 000 2014 6 24 2014 6 26 0 90 1 00 Mizuho International Plc 2014 7 9 2014 6 20
48. TDM 511 3 D Matrix Inc 2014 10 22 FDA 510 k 1 510 K 510 K PMA 90 FDA 510 K FDA 90 FDA
49. DDS MTA O
50. PP ee se TDM 641 Japan TDM 631 US TDM 511 2015 6 TDM 621 0 WI RADA16 TDM 621 TDM 621 TDM 621 pH
51. q B PuraMatrix B 2014 4 2014 4 1 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7
52. FDA Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 TDM 711 FDA TDM 641 2014 12 TDM 511 2014 10 FDA 510 k 2015 2 510 k 2015 4 2 2015 4 2
53. TDM 621 2009 2015 4 5 RADA16 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7
54. 2014 11 6 PuraStat 2014 1 14 PuraStat CE 2014 10 30 Pamela Youde Nethersole Eastern Hospital PYNEH 11 6 Chung Ngai TANG M D Chief of Service Department of Surgery and Director of Minimal Access Surgery Training Centre of PYNEH PYNE 5 000 2014 11 4
55. TDM 621 TDM 711 TDM 641 TDM 631 TDM 511 TDM 621 RADA16 TDM 621 97 7777 SR Research Report 2015 7 PuraMatrix Corning Incorporated
56. 3 497 70 309 751 2018 4 CE EU
57. SR Inc SR Inc http www sharedresearch D Email info sharedresearch p 3 31 12 03 5834 8787 Sh aredd KMesearch http Wwww sharedresearch jp Copyright C Shared Research Inc All Rights Reserved
58. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 2 3 2014 5 12
59. 2014 8 8 2015 4 1 160 2015 4 2016 4
60. 783 2 877 100 1 996 24 1 903 2 004 16 1 795 2 005 11 1 995 582 675 176 2 175 25 316 409 266 5
61. PP Sn 2 2014 9 2014 9 10 Sh aredd Mes
62. MIT TDM 641 TDM 641 2014 9 9 IPMDA PMDA Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 2014 12 11 EMR ESD 7 PMDA
63. SR Inc Shared Researcn SR Inc SR Inc SR Inc SR Inc
64. MG VOYAGE GROUP SBS KLab J
65. 2015 4 75 2015 4 777 11 2015 4 187 3 D Matrix Inc 70 2019 4 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 a 5
66. R Arg ADME ADME Absorption Distribution Metabolism Excretion ADME Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 SIRNA 21 23 RNA siRNA RNA RNAi RNA mRNA siRNA MTA Material
67. 3 D Matrix AsialPte Ltd SG 3 D Matrix Da America Fe Representacao Comercial Ltda http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 MIT
68. 3 D Matrix Europe SAS5 PuraStat CE 2015 3 6 2014 1 14 PuraStat CE CE CE EU 28 3 D Matrix Da America Latina Representacao Comercial Ltda 2015 2 2015 2 16 TDM 511 510 k
69. Sh ared CCT ch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 1 lt gt TDM 621 TDM 6 1 TDM 621 C IE 1987 C 1 200B 1
70. 50 300 SEE PRE 7 000 6 058 coon SE 5 914 5 931 180 176 4 o 169 2 168 6 171 0 171 3 170 7 5 000 160 4 000 2 000 pe 120 1 000 100 07 0O8 0O9 10 11 12 13 14 2009 2006 2007 2008 Shared Gxcscarch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7
71. 2015 2 2016 4 3 2015 6 1st Pilot Study 15 2nd Pilot Study FDA 2016 4 2014 10 FDA 510 k 2015 2 510 k 2015 6
72. Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 68 93 7777 SR Research Report 2015 7 Scaffold GLP Good Laboratory Practice pH
73. 3 DMatrix Asia Pte Ltd PuraStat 2014 9 3 2014 1 14 PuraStat CE CE CE EU 28 2014 6 3 CE Health Sciences Authority 3 D Matrix Asia Pte Ltd
74. TDM 641 TDM 641 Sh ared GYcsea ch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 TDM 641 IITTITITDL TUUTITTT TDM 641 TDM 621 RADA16 TDM 621 TDM 641
75. shared esearch lp http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 201577 7 2016 4 PMDA 2016 4 2016 4 EU
76. C 2016 4 3 2015 6 DDS 582 675 176 2 175 CE
77. MIT MIT MIT 2001 5 3 D Matrix Inc esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 3 D Matrix Inc 100 3 D Matrix Europe SAS 1009 3 DMatrix EMEA 100 3 D Matrix Asia Pte Ltd 100 3 D Matrix Da America Latina Representacao Comercial Ltda 1009 100
78. 5558104 3 D Matrix Inc 2014 6 17 3 D Matrix Da America Latina Representacao Comercial Ltda 600 000 27 2014 6 13 99 3 D Matrix Europe SAS 19 2014 6 5
79. 6 2016 1 344 iDATA Research 2016 1 078 millennium 30 509 2016 1 344M ipATA 1 600 M 1 400 1 200 1 000 800 600 400 200 CY06 CYO7 CY08 CY09 CY10E CY11E CY12E CY13E CY14E CY15E CY16E SEALANTS mHEMOSTATS 2016 1 078M 1200 M 2010 2016 1 000 800 600 400 200 CY10 CY11 CY12 CY13 CY14 CY15 CY16 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7
80. CE PuraStat 2015 1 27 MIT 3 D Matrix Asia Pte Ltd A DDS
81. CE PuraStat 2014 9 1 2014 8 21 D Matrix Asia Pte Ltd 1009 20 100 2014 8 2014 8 28 PuraStat
82. TDM 641 2014 12 11 EMR ESD 2015 2 17 PMDA 2015 4
83. 2016 4 3 2016 4 2 877 2 094 1 024 208 25 5 CE Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7
84. 544 589 1 758 2 033 2 641 5 137 52 33 39 25 261 789 777 17 39 718 190 163 290 594 666 2 501 2 484 3 593 6 204 7 6 88 107 103 94 19 22 30 47 86 118 537 467 397 327 257 187 42 38 40 46 56 136 578 505 437 383 339 393 604 533 554 536 528 605 1 198 1 199 3 055 3 020 4 121 6 809 12 16 22 48 92 139 4 24 30 43 37 33 15 9 59 821 829 238 31 49 112 913 958 409 0 55 42 29 18 0 55 42 29 18 31 49 167 955 988 428 1 109 1 359 2 070 2 139 3 339 5 930 1 099 1 349 2 060 2 129 3 329 5 920 1 063 1 596 1 288 2 266 3 792 5 787 11 19 34 228 341 1 167 1 150 2 888 2 066 3 133 6 382 21 22 3 213 697 690 544 589 1 758 2 033 2 641 5 137 SR
85. MIT MIT PuraMatrix PuraMatrix 7 1 7 A A 1 NGO uo NG uo Pu uo NG 9 E F Ac R A D A R A D A R A D A R A D A CONH R A D 1 2 3 4
86. 3 D Matrix Asia Pte Ltd 3DMA A STAR Exploit Technologies PTE LTD ETPL A STR Institute of Bioengineering and Nanotechnology IBN Dr Charlotte Hauser ETPL 3DMA 6
87. 2014 4 19 3 D Matrix Inc 2004 3 D Matrix Inc 2000 4
88. 03 3511 3440 2004 5 19 HP http www 3d matrix CO p index html IR http www sharedresearch jD 2015 7 102 0083 3 2 4 HF 7 2011 10 24 4 TIR httDp www 3d matrix CO p ir index html Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 SR
89. 4 3 4 gt i FY lI A A A A mC E gt YS 10 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 201577 7 SW Strengths Weaknesses Strengths MIT
90. DN NN TDM 511 2015 3 3 amp
91. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 OTC Over The Counter I 2015 4 TDM 641
92. PMDA 2015 3 PMDA 2016 4 2014 1 CE CE 2014 8 4
93. 2 100 MTA MIT MIT 3 D Matrix Inc 2003 4 MIT Exclusive Patent License Agreement MIT 2004 10 3 D Matrix Inc
94. MIT Sh ared 5 HLT ch lp http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 CSL amp 1 4502 2009 Medmarket Diligence 1 4503 1 3401
95. TDM 641 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 10 4 11 4 12 4 13 4 14 4 15 4 402 158 1 107 32 107 100 60 696 599 596 97 196 234 796 6 9 2 8 7 0 6 3 400 150 1 100 32 101 96 1 2 3 0 3 2 467 641 753 1 031 1 626 2 003 111 233 251 395 599 816 355 406 499 636 1 024 1 185 65 482 354 999 1 518 1 903 32 0 11 0 3 38 32 153 0 0 0 0 1 3 1 34 27 141 2 2 4 4 5 27 48 17 38 45 0 8 12 8 6 6 6 4 2 2 14 1 16 32 60 510 310 978 1 524 1 795 28 0 3 1 21 1 1 2 5 61 534 309 978 1 525 1 995 27 9
96. ISO13485 TDM 621 FDA IDE Investigational Device Exemption CE EU EU CE TDM 711 2012 2 15 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 FDA
97. 1 2005 2007 2012 7 INSEAD MBA 1996 2006 CSBA 2007 CSBA 2008 JASDAQ 2008 2012 7 2014 4 35 19 38 9 3 4 Sh ared Kesearch http www sharedrese
98. Health Sciences Authority 3 D Matrix Asia Pte Ltd CE TDM 621 2014 5 2014 5 30 3 2014 2
99. KOL Key Opinion Leader Sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 201577 7 2014 4 2014 6 12 2014 4 TDM 621 107 234 7 1 626 57 6 599 51 5 1 024 61 0 1 518 999 1 523 97
100. 9 9 PuraStat 2014 6 10 2011 5 31 PMDA 2015 3 13 2015 3 2016 4
101. 510 k 2015 2 510 k 510 k http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 201577 7 Massachusetts Institute of Technology MIT MIT MIT
102. CSL 1 4559 AH 1 4543 1 4471 sSh ared 1 ch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7
103. OD TDM 621 CE 3 D Matrix Inc 2007 10 3 D Matrix Inc 2009 4 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 201577 7 amp 2015 3 2015 3 13 TDM 621 TDM 621 3 2011 5 31 P
104. 1st Pilot Study 2012 6 15 2014 5 FDA 2015 2nd Pilot Study TDM 511 TDM 511 TDM 511 1 2
105. 2 Phase 1 2011 5 RPN2 A6K DDS siRNA siRNA 2015 4 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 RPN2siRNA A6GK RPN2siRNA DDS A6K DDS 2012 3
106. TDM 511 FDA 510 k Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 2014 8 8 160 1 2014 7 9 1 2 526 sSh ared
107. TDM 621 2014 1 CE CE 2014 KOL key opinion leader TDM 621 2015 3 60 PuraStat CE PuraStat 3 D Matrix Asia Pte Ltd 2014 6 7
108. 2013 7 5 SMBC Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 10 8 07 5 27 BBH For Oppenheimer Global Opportunities Fund 4 53 4 35 3 75 3 22 2 01 1 96 CBHK Korea Securities Depository Daishin 1 61 Pershing Div of DLJ Secs Corp 1 54 SR 2014 4 30 24 69 9 1
109. 8 9 4 589 9 468 19 876 21 438 EPS 7 871 58 896 74 105 78 95 EPS 69 DPS BPS 137 634 2 120 159 5 625 1 107 3 146 2 281 8 13 568 15 168 18 355 18 936 19 876 21 438 EPS 4 35 18 53 78 95 EPS 17 DPS BPS 86 0 75 1 156 3 53 7 146 2 281 8 SR 2011 7 1 2011 8 1 2012 9 1 2 2013 6 1 100 948 4 1 3 792 2 9 222 18 936 2014 4 1 064 2014 4
110. 1009 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 3 D Matrix EMEA 300 000 2015 4 22
111. 2 009 2 080 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 2015 4 16 PuraStat PT Teguhsindo Lestaritama 50 PuraStat 3 13 2015 3 13 2016 4
112. 510 k DDS DDS DbFGF PDGF A6K siRNA Phase I
113. 7777 SR Research Report 2015 7 14 4 15 4 15 4 P46 cte pe cte 48 1 51 0 0 0 100 102 9 97 58 4 96 8 146 136 145 171 141 281 181 214 59 7 50 0 61 69 39 1 3 7 106 1 24 796 24 8 222 221 232 349 297 286 328 274 65 9 62 696 40 7 73 296 33 696 29 3 41 7 21 59 321 356 372 470 438 567 509 389 1 918 341 361 357 466 471 514 438 372 1 814 341 361 357 467 635 514 439 407 2 009 SR 2015 4 2015 4 100 107 1 903 1 518 1 795 1 524 1 995
114. Arista AH MedMArket Deligence TDM 641 TDM 641
115. GCA DIC TOKAI
116. TDM 511 3 D Matrix Inc 2014 10 23 FDA 510 k 2015 2 13 TDM 511 510 k Rx Prescription
117. TDM 641 2014 12 3 MIT 8901084 Massachusetts Institute of Technology 2010 7713923 7713923
118. 3 2015 3 13 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7
119. 7 9 9 PuraStat 2014 6 10 PMDA FDA TDM 711 FDA TDM 641 2014 9 PMDA
120. PuraStat CE 2014 7 1 St John of God Hospital St John of God Hospital Department of Surgery Bernhard DAUSER M D 4 000 2014 6 2014 6 25 1 270 000 1 600 000 PPP 21 184 800 21 514 800 5 016 6 283 4 84
121. SU 1 2 3 3 gm http www sharedresearch jp Copyright C Shared Research Inc
122. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 2014 1 14 PuraStat CE 2014 8 26 Heart and Diabetes Center NRW Clinic for Thoracic and Cardiovascular Surgery Michiel Morshuis MD 5 000 J 2014 8 8
123. 2016 4 3 100 2015 6 2016 4 i
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125. 2014 9 PMDA 2014 12 EMR ESD 260 2015 3 2012 2 Sh ared GYcsea ch http www sharedresearch jp Copyright C Shared Research Inc All Rights Re
126. 2015 3 TDM 621 2016 4 Sh ared 1 ch lp http Www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved ET 7777 SR Research Report 2015 7 7 2010 9 17 Daewoong Pharmaceutical Co LTD PARTNERSHIP AGREEMENT Excelsior Medical Co Ltd LICENSE AGREEMENT 2013 5 29 3 D Matrix Asia Pte Ltd PT Teguhsindo Lestaritama 2015 1 2014 7 CE
127. 7777 SR Research Report 2015 7 300 2011 4 158 2010 4 402 150 2010 4 400 641 2010 4 174 50 TDM 621 122 482 2010 4 65 510 60 534 61 sSh ared 1 ch lp http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 10 4 11 4 12 4 13 4 14 4 15 4
128. 7777 SR Research Report 2015 7 2015 1 2015 6 2015 3 2016 4 TDM 641 2014 12 201 5 3 TDM 631 2016 4 2017 4 2018 4 TDM 711 2012 2 2017 4 2018 4 TDM 511 2014 10 FDA
129. 2014 1 15 ITDM 621 CE 3 D Matrix Europe SAS TDM 621 CE 2014 1 14 EU TDM 621 1 000 ASEAN 2014 3 2013 6 13 2013 7 2013 7 31
130. 9 2 1 oe 20 SB 23 2 0 23 or 24 Eo EE NT 41 LMM 42 Ea GG 45 EE EE 5 eo 46 SW Strengths Weaknesses 49 50 TP 54 1 55 L ANLiLiirnnanasrtetensatttetatesbetetetete 55 oo 58 60 EE 62 ES 64 PH 64 A CE TR pp 66 7 85 ESETTTTTTTTTSSES TRI 85 a 85 86 CC 87 87 92 Sh ared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 201577 7 Massachusetts Institute of Technology MIT 1 4 1 MIT MIT
131. TDM 621 TDM 621 TDM 621 PMDA TDM 621 PMDA 3 D Matrix Inc TDM 711 FDA IDE TDM 641 TDM 711 TDM 621 3 D Matrix Europe SAS 3 D Matrix Asia Pte Ltd TDM 621 FDA IDE ISO13485 PT Teguhsindo Lestaritama TDM 621
132. 3 TDM 711 Py N el 4 amp 4 SN hitp wirw sanramonoralsurgery com bonegrafting htm 1 1 TDM 711 TDM
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134. 1 525 3 51 816 36 3 1 185 15 8 141 1 3 5 2 54 8 3 72 7 4 10 0 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7
135. 2015 1 2015 1 29 PuraStat Daewoong Pharmaceutical Co Ltd PuraStat Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 2015 1 29 CE 2014 1 14 PuraStat CE CE CE EU 28
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137. 10 30 PMDA TDM 511 2014 10 FDA 510 k 2015 4 1 2014 9 12 2015 4 1 2015 4 1 0 48 438 321 471 341 635 341 Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 1 2015 3 TDM 621
138. 2014 7 2014 7 18 ITDM 621 3 D Matrix Asia Pte Ltd PT Teguhsindo Lestaritama 2014 7 18 TDM 621 2014 6 3 2 CE Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 Ministry of Health 2015 4 2014 7 14 PuraStat 2014 1 14
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142. 2015 4 CE 2014 7 2015 3 20 53 CE 2014 6 9 2014 7 2015 4 2015 1 2015 6
143. RNA DDS DDS siRNA http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 CPC Scientific Inc 3 3 TDM 621 2011 5
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147. SR 2012 4 SR Research Report 2015 7 1 107 1 TDM 621 2 TDM 641 3 753 354 3 14 26 48 310 309 2012 4 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved
148. 2015 4 16 PuraStat 3 D Matrix Asia Pte Ltd PT Teguhsindo Lestaritama 2015 4 16 Ministry of Health PuraStat 2014 1 14 PuraStat CE CE CE EU 28 2014 7 18 CE
149. PuraStat 2014 1 14 PuraStat5 CE 2014 10 30 Hospital San Borja Arriaran Clinica Las Condes Hospital San Borja Arriaran Cristian Baeza M D Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 2014 10 2014 10 23 TDM 511 510 k
150. PT Teguhsindo Lestaritama Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 Daewoong Pharmaceutical Co LTD Excelsior Medical Co Ltd 2015 6 2016 4 3 000 CE CE M 3 500 USD3 000M 3 000 CE 2 500 286
151. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 3 PuraMatrix ReproHepato 2014 PuraMatrix ReproHepato PuraMatrix 3 ReproHepato PuraMatrix
152. License and Supply Agreement 3 D Matrix Inc 2007 10 3 D Matrix Inc 3 D Matrix Inc MIT Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 28 NN US 6548630 MIT 2003 4
153. R A D 3 RADA 16 pH ADME 30 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 DDS
154. 11 345 4 377 4 361 3 000 2016 4 2015 4 2016 4 2017 4
155. 2 000 1 078 1 085 185 94 1 3 1 500 J 86 80 1000 1 14 000 1cc SR 1 078 millennium Fibrin Sealant Gelatin Bioglue 8 PuraStat http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7
156. 2010 1 97 2011 4 TDM 621 5x7 2011 5 PMDA TDM 621 PMDA
157. m E 9 i P cro pa i a Mh 3 9 2 5 U 5a 6 se ij 1 2 3 4 PMDA FDA 5 PMDA FDA 6 2 3 7
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160. 30 e00B 1 14 6 1 2009 11 30 2010 1 2007 12 160 2008 1 2009 3 TDM 621
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162. TDM 621 TDM 621 2014 12 22 TDM 621 2015 2 2014 6 12 2014 12 11 TDM 641
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166. 55 CE CE PMDA Shared esearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 7777 SR Research Report 2015 7 7 CRO 2 3 2017 4
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