複数のスパイク用遺伝子等 から調整したRNAを測
Contents
1. 10 20 30 50 9 JP WO2003 100422 1 2003 12 42. 10 20 30 50 JP WO2003 100422 Al 2003 12 4 72 10 20 30 50 LI LI LI 73 JP 2003 100422
3. 10 20 30 50 27 JP 2003 100422 A1 2003 12 4 10 20 30 50 28 JP WO2003 100422 Al 2003 12 4
4. 00000000 0000 DOO n E n n 5 5 se 5 000 00 DOO 000 0 DODO 000 00 DODO 000 00 IL 0000 000 n 10 20 30 50 39 WO2003 100422 1 2003 12 r1 r3 m m r3 r3 r3 n mon EXC E 5 PAP fux rz 5 n n
5. 10 20 30 50 37 JP WO2003 100422 Al 2003 12 4 L II UU IO UU L LI II LI LI II II II II II II II II II 10 20 30 50 38 JP 2003 100422 A1 2003 12
6. 10 20 30 50 20 2003 100422 1 2003 12 10 20 30 50 21 2003 100422 A1 2003 12 4
7. II LI ES LI LI E MEE RT 63 SA 3 FR PUMICE D 21 30 Afe tuu LOPES or L A PRESARING COCKTAIL OF SPIKES CORRESPONDING TO I IIGI L MEDIUM AND LEW EXPRESSION GROUPS WITH ARTIFICIAL RNAS AS EXTERNAL CONTROLS AND EFFECTING HYBRIDIZATION FIG 2 E UPLURAL SPOTS MAY BE FORMED FOR EACH SPIKE AND HOUSEKEEPING GENE 5 1 D SPIKE 2 E SPIKE 3 F CONIROL GENE IN SAM2LE iHOUSEKEEPCING GENE EIC 1 G CONTROL GENE IN SAMPLE FOLSEKEEPOING GENE ETC 2 CONTRO GFKF IN dOUSFK FPOING 13 L GENES FOR EXAMPLE ASSIGNING 3 SPOTS FOR
8. 11 JP WO2003 100422 Al 2003 12 4 10 20 30 50 12 JP 2003 100422 A1 2003 12 4 u u u n
9. LI LI LI II II II II II II LI LI II II II II II II II L L L LI LI LI II II II II II II II II 10 20 30 50 33 2003 100422 A1 2003 12 4 10 20 30 50 34 2003 100422 1 2003 12
10. E nnunnnnnnnnunnnnmn L LI LI O O 10 20 30 50 29 JP 2003 100422 A1 2003 12 10 20 30 50 30 JP 2003 100422 A1 2003 12
11. 46 JP WO2003 100422 Al 2003 12 4 K 2 pes pee pee pius 0237 637 6237 IGP3 0 IGP3 WE MRE MAE w alpha 1 antitrypsin Bes lus 5611 alpha 1 antitrypsin sl 4161 alpha 1 antitrypsin 6903 NADH dehydrogenase 4 gt 14972 dehydrogenase 4 18101 18883 banu dohyarogonase a testo be 10060 NADH dehydrogenase 4 es le 15184 13581 10 20 mitochondrial 165 mitochondrial 165 rRNA mitochondrial 47 JP WO2003 100422 1 2003 12 4 21078 E E 17500 20906 18145 21945 2 2539 1208 2003 059 1386 DI ER 5 1 pos DI r Da a B 10 20 30 48 JP WO2003 100422 1 2003 12 4 H Ir H Di c Q 8 H B m M Le H et c D tp ca ca nen bo DI o e o co O co 103715 t 2v o DI I e O R
12. 10 20 30 50 35 JP WO2003 100422 1 2003 12 4 10 20 30 50 36 JP WO2003 100422 1 2003 12 4
13. 10 20 30 50 WO2003 100422 10 20 30 50 23 JP 2003 100422 A1 2003 12 4
14. 10 20 30 50 15 2003 100422 A1 2003 12 4 10 20 30 50 16 JP WO2003 100422 Al 2003 12 4 10 20 30 50 17 JP 2003
15. 10 20 30 50 40 JP 2003 100422 A1 2003 12 4 n 10 20 30 50 41 JP WO2003 100422 Al 2003 12 4 0000000 3122 ve DECEM 2052 Lon
16. X Y 1 O P amp E 5 OF 10 09 ERMAN AROS TA iste ROSMA 2 27 9015 I SA JP 2 1000 8915 4263 03 3581 1101 3251 HKPCT ISA 210 2 199874 83 JP WO2003 100422 Al 2003 12 4 11011100 II II I
17. JP WO2003 100422 1 2003 12 4 3 10 20 30 HHHHHHHHHHHHHH 1000000000000000 50 LI LI LI I I LI LI n JP WO2003 100422 1 2003 12 4 4 10 20
18. xUx 4 10 20 30 50 31 JP 2003 100422 1 2003 12 4 10 20 30 50 32 JP WO2003 100422 1 2003 12 4
19. 10 20 30 50 24 JP 2003 100422 A1 2003 12 4 10 20 30 50 25 2003 100422 A1 2003 12 4 10 20 30 50 26 JP 2003 100422 A1 2003 12
20. L LI LI LI LI II LI II II II II II II II II II II II II II II II II II II II II II II II II II 51 JP WO2003 100422 1 2003 12 4 3 HAT FA 603297 Ti _ Ti Cy3 M Cy5 E 5334 1 180 0 635 0 2 4065 1 342 0 978 1 5668 1 180 1 0600 0 1 17814 T 1 456 211 IN 14270 11006 1 297 0 787 1 143 10 20 30 52 JP WO2003 100422 Al 2003 12 4 383740 T 0 033 368 gt 1 gt 1 1 093 0 760 i 0 930 289854 1 0231 1 180 0 644 0 509 342079 352692 0 970 0 459 0 437 L 53 WO2003 100422 1 2003 12 4 141 17749 20992 0 TTL 0 804 17784 22114 0 045 0 145 1 478 339266 388639 0 8731 1 177 1 187 0 AT 328093 362272 0 906 0 207 0 305 10 20 30 54 JP WO2003 100422 1 2003 12 4 111 317800 1 020 0 1 gt 274409 0 967 1 384 1 239 T 315013 0 905 0 734 0 221 0 407 336248 0 848 0 735 0 312 0 103715 0 932 0 281 0 708 0 748 105136 1036301 L 015 1 248 0 TY L35 91889 96876 949 1 153 0 010 se protein 10 20
21. Cy3 Cy5 17 x 5g 9 gt E o e 8 gt Fox n e 5 boss e e SAO 906 19 8 1 gt 9 n il N gt 8 5 a 2 5 8 gt o en Ss 4 e a 8000 6000 4000 VILLE TU 2000 20000 dele 18 1000000 Bu g qu 100 10000 1000000 Sample I LI LI LI 20 1000000 E 10000 100 El 100 10000 1000000 Sample Oy3 78 1RNA itt JP WO2003 100422 A1 2003 12 10000 19 10000 5 1 NR 000 100 E op 1 1 10 100 1000 10000 log Cy3 1000 21 1000000 100000 8 10000 A 5 1000 100 100 1000 10
22. I L LI LI I LI LI 100 LI 20 30 0000 50 10000 LI 100000 1000000 100 LI I LI LI II LI II II II II II II II II II II II II 0 1000000 LI I I LI LI 1000000 HHHHHHH LI 8 JP 2003 100422 A1 2003 12 4
23. 1000000 100000 1000000 I I II II II HHHHHH LI 30 I LI II II II 10000000 L II II LI II II I1 II II II 100000 100 10000000 1000000 1000000 1000000 0000000 0000000 50 JP WO2003 100422 1 2003 12 4 6
24. SF 7 11 13 1020 102 12 102b mete ET fremmes pe rammes pl JP WO2003 100422 Al 2003 12 4 77 MR CI 5 HS 22 14 8 At E E EDS F LO HE FLORAL atl za p et o EAS ss d 4 BOB FLOPLG LE 06 22 BCrAFLOR ARE AER shao 19 LENTE DROS Meh OS COR THOSE 9 5 PIANO TI EAE E MOTA BEC EE AFL IPS 1918 14 Cy3 Cy5
25. 60000060 00909009 90000000 00000006 00900908 20800600 00006000 62000000 00000008 20800080 00000600 00900000 00009000 80080000 0000600 09000090 circle SB 3 SB 4 x i Cy3 Cy5 JP WO2003 100422 1 2003 12 4 75 8
26. LI LI HHHHH L LI LI L LI LI LI LI LI LI II II II II II II II II II L L LI LI LI II II II II II II II II II II L II LI LI II II II II I LI II II II II II II LI II II II II II II O 10000000 L LI LI II II II II II II II II LI O LI LI II II II II I 10 20 30 50 JP WO2003 100422 1 2003 12 4 10 10 20 30 50 I LI II LI II 100000 nnnnnnnn
27. nnnnnnnnnnnnnNnNnNn du Se Cone arie e de ge s 10 LI I IIIIIIIIIII II L L LI LI L le SR M 21521455005 gt DD ES 20 0000000 x gt 322 Es O00000000000000000000000000000000000000 E a r1 GET ESTE GER TT FP r1 TN 30 me antitrypsin alpha 1 antitrypsin 40 alpha 1 antitrypsin 1 1 antitrypsin SERE ADH dehydrogenase 4 wed md ies com sm ies 2159 1000 ADH dehydrogenase 4 ADH dehydrogenase 4 50 168 rRNA mitochondrial 165 rRNA mitochondrial mitochondrial ribosomal protein ribosomal protein 141 ribosomal protein 141 ADH dehydrogenase NADH dehydrogenase NADH dehydrogenase NADH dehydrogenase Apolipoprotein E Apolipoprotein Apolipoprotein E Apolipoprotein ferritin light chain ferritin light chain 42279 43473 41526 41948 33543 40455 31935 37689 1743 2477 1357 1843 1 DI 1 120 37379 36148 DI 2 T 41610 38726 39046 25184 28095 26766 1441 2007 1041 42 65535 65535 65535 JP WO2003 100422 1 2003 12 4 65535 65535 65535 65535 65535 65535 65535 65535 65535 65535 25580 65535 65535 6553
28. 52 Int d 37 00 1000 15 00 72 79000 OG 0 72
29. LI 100 LI LI 10 20 30 50 L LI LI L II II LI II II II II II II II II II II II II II II II II II II II II II II II II JP WO2003 100422 1 2003 12 4 7 LI LI LI LI 1000 I I LI LI LI LI LI LI 10
30. 69 JP WO2003 100422 Al 2003 12 4 207958 211853 0 955 sa 3931 2261 1 784 102 2583 1 747 657 1976 1 922 283 10 4512 sos 2207 amen 1976 one 24905 25899 0 962 25996 28195 000000 100 II II II II II II II II II II II II II II II II II II II II II II II II II II LI LI LI II LI II II II II I I II II II I II I II II II II II II I II II II II II II II I I II II II II II 1000000000 100000000000000 BB B 100 HHH HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH 000000 IL I LI LI LI I LI II II II II II II II II II II II II II II II II II II II II II II II II II II II II II II II II II LI LI LI II II II II II II II II II II II II II II II II II II II II II II II II II II II II II II II II II 100000 100 100 100000 10000 IL I LI L 1000000 II II II II II II II II II II II II II II II II II II II II II II II II II II II II II II II II II 10 20 30 50 71 JP WO2003 100422 Al 2003 12 4
31. I I LI LI I LI LI I LI LI I LI II II II II II II LI 000000000000000000000000000000 30 LI I L LI LI 100 100 100 100 0010 1000000 L LI LI L II II II II II II II II 50 JP WO2003 100422 Al 2003 12 4 5 10 20
32. Ela grax fit Y 4 EL ZIEH TH LGG PA BS is ag I 9601 HEKSA lt ey HEL 27 2901 00 zop 900 BY TL E AMIELHY BETY soU f 97406 y 2 VNG 1 00 mar vip 98 EE RA sus EE EH i ge V lt lt XC6 lt 4 X 00L ES VALUGLAVNA 2 BEA Y RISI TLY ABS J AYNA x G 99 52 A By sau su SNP SE VLYALZIAEZLYLANLOGHLAVNO 1 8 76 JP WO2003 100422 1 2003 12 4 9 10 SE 1 n 1 SF 2 Y pucr cB n ai BAIN FEST i y 5554 n 1 Lses SF 6 SF 4 n
33. 1922 1996 1994 2003 1996 2003 2001 41892 A 1 51 2001 02 16 5 1116949 A INCYTE GENOMICS INC 1 51 12 amp JP 2003 516166 A WO 01 0425 2001 06 14 A ISIS INNOVATION LIMITED led WO 017040 3 amp JP 2003 515328 A 30 2001 06 07 C O T 5E
34. ZB A BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG V MX MZ NO OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ YU ZA ZM ZW 5 1 54 DN A DN A D NA 1 A RNA FO EET BRIT ENIT CEL 52 er 58607128 y FAI APT ni j1F 2 244 92 PACS AA ARE FAFS oN BE EU
35. thymosin beta 10 thymosin beta 10 22920 44 65535 65585 65535 JP WO2003 100422 1 2003 12 4 65535 65535 65535 65535 65535 5 65535 65535 o 69 e 65535 65535 553 65535 65535 Co 65535 65530 6553 65535 65535 2276 5813 2713 6218 35997 RL ATI RNA 26235 to j 10 1 4 O lu I G1 CI 2098 5390 65535 65535 65535 65535 65535 65535 65535 css 65535 65535 650 esso ess 65533 65535 65535 65535 65535 65535 65538 6553 65535 GP CAT RNA 36279 37969 4774 50220 1951 29396 29223 39148 38537 GP AT RNA AT RNA 2911 GP CAT RNA 3077 2349 28986 30726 39314 3262 2142 1981 3205 28664 41841 4559 2937 41807 39764 56294 26241 26069 27466 36118 37177 30238 38064 39632 40521 37472 53478 10 20 30 45 JP WO2003 100422 Al 2003 12 4 LP RNA 1692 25269 28592 33954 1619 2000 2510 soon 3290 20800 xor 2583 1849 25597 27405 34621 LP RNA 3085 2000 29429 29516 41849
36. GENE J EFFECTING RORMALIZATION EASED ON SIGNAL INTENSITIES OF SPIKES CF EACH MEASUREMENT DATA FIG 31 K EXTRACTING OPTIMUM SIGNAL NTENSITY FROM MEASUREMENT USING ONE OF THE SPOTS 17030 GENE VIA DATA MERGE PROCESS NG I IC 4 L ANALYZ NG ON SIGNAL INTENSITY EXTRACTED FOR GENE DATA MINING C USIEHING EIG JP WO2003 100422 1 2003 12 4 2 10 20 30 00000 100000000000000 10000000 100 1000 n 100000 50 L LI LI L LI II LI II II II II II II II II II II II II I II II II II II II II II II II II II II L LI LI L II II II II II II II II
37. 100422 A1 2003 12 4 10 20 30 50 18 JP WO2003 100422 Al 2003 12 4 10 20 30 50 19 JP 2003 100422 A1 2003 12 4
38. 30 55 JP WO2003 100422 Al 2003 12 4 protein L35 1 99277 82909 1 197 0 186 434 329645 4451411 0 7411 0 444 0 029 HE 3504111 494950 0 708 1 081 1 219 1 274424 365659 0 750 1 248 0 466 306137 402541 0 761 0 276 0 440 0 E 1485 1 825 1 345 0 639 1 388 1452 2 267 0 4 1 068 0 88 244109 317853 0 768 1 438 1 1311 0 779 E al 2 c ce I GAPDH 222898 285042 0 403 0 445 0 683 ES GAPDH 17638 243884 0 892 0 860 0 415 0 om GAPDH 225521 208129 1 084 0 178 1 162 1 xe 10 20 30 56 JP WO2003 100422 Al 2003 12 4 thymosin 188698 236196 0 799 0 366 1 139 beta 10 XII 208757 247356 0 844 1 220 0 AU 2080301 224231 0 928 0 4771 0 549 0 642 207958 2178531 0 955 0 470 1 037 1 013 NE 3931 2267 1 734 0 165 0 270 0 al 4512 2583 1 747 1 455 1 295 0 804 EI 0 537 3797 1976 1 92 0 674 3720 1908 1 949 0 753 0 892 u 0 0 719 0 778 0 078 un a 714 0 0 704 1 933 0 945 0 410 0 740 0 RNA 388896 427814 0 909 2 056 0 706 omx 0 670 E H RL 10 20 30 57 JP WO2003 100422 Al 2003 12 4 jal GP 34019 1 112 0 465 RNA cp nei fica
39. sa RNA 24905 RNA GP AL 25996 28195 0 si a ll RNA 27716 dai a i o 0 RNA 29840 ne 0 RNA RNA RNA RNA RNA LP I RNA P A RNA mw 28475 27096 1 051 1 842 0 966 0 901 A RNA 10 20 30 50 58 JP WO2003 100422 Al 2003 12 4 LI LI SEE LI II II II II II II II II II II II II 15685 11006 3262 395 Cy5 10 20 14746 13403 30 40 59 WO2003 100422 1 2003 12 4 dehydrogenase 383740 504978 380459 509923 376901 510288 380736 514505 IAN TA PA A A 165 rRNA mitochondrial 165 rRNA mitochondrial mitochondrial ribosomal protein L41 ribosomal protein 141 dehydrogenase 10 20 30 Apolipoprotein E Apolipoprotein E Apolipoprotein Apolipoprotein 60 2447 1222 JP WO2003 100422 Al 2003 12 4 B 326232 339266 388639 328093 362272 311338 343969 211365 369579 265248 284998 285007 96700 278154 323812 101407 10 20 30 61 306137 222898 285042 217638 243884 225521 208129 JP WO2003 100422 1 2003 12 4 315154 222019
40. 19 JP 17 9 29 2005 9 29 JP WO2003 100422 1 2003 12 4 A1 11 102003 100422 43 15 12 4 2003 12 51 Int C1 L I GO1N 33 53 GO1N 33 53 M C12M 1 00 C12M 1 00 C12N 15 09 C12Q 1 68 120 1 6 GO1N 33 566 GO1N 33 566 GOIN 37 0 102 A 83 2004 507828 P2004 507828 71 HERA 501029744 21 PCT JP2003 006677 22 15 5 28 2003 5 28 2002 154773 P2002 154773 14 5 28 2002 5 28 33 QP 81 AP GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW EA AM AZ BY KG KZ MD RU TJ TM EP AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU LE IT LU MC NL PT RO SE SI SK TR OA BF CF CG CI GA 5 1 14 100089118 74 100113103 Fer 5 72 ZE E 5 1 GN GQ GW ML MR NE SN TD TG AE AG AL AM AT AU AZ B 72
41. 5 E D D Ca D fo D c wo o C w E kei c Cn bo DI QI gt E y 53 m 9 le O E 15 E 3 En eO CO de D CO 4 82909 ribosomal protein 1 35 99277 ribosomal protein 58 329645 446141 ibosomal protein 56 274424 365659 ibosomal protein SG 306137 402541 Q a o 8 e E o 4 ct co E Ha tel 3295 orse 1520 1496 3412 1693 2630 1449 3702 1528 3170 1525 3384 1379 Garon 2228 bessoa _ bem qure fused u ES 209129 bwmoein bete 10 aseos bete 10 fost mosin beta 10 208009 mein porse 3738 laa 2133 EE 2543 3803 1966 4374 2623 52 3792 1985 10 20 30 49 JP WO2003 100422 1 2003 12 4 sors 303468 416943 281849 392157 303841 1425732 294882 278926 326722 345696 388895 83973 34642 34500 35588 33585 35505 26340 25708 27954 27301 27539 27245 GP RNA 26421 28225 24791 28342 26777 RNA 27928 30963 27565 28709 27656 28648 41379 38701 39757 37271 30601 37808 28001 26354 27986 27665 29
42. A1 2003 12 4 5 E m 3 10 20 30 74 JP WO2003 100422 1 2003 12 4 ts lt e 1 DT ie d xem ls E Us 5 PES lt EN RNA g 14 4 E EIE Y UE 812 ERES ER k EE EE eS iS ES M 2 E L 1 3 1 UNS AX E BIST 909098 3
43. 000 100000 1000000 10000 22 1000000 100000 RE 10000 K 3 M 7 1000 100 100 1000 10000 100000 1000000 2RNA 4 1000 24 1000000 100000 L3 5 lt amp 10000 K A N E 7 1000 100 100 1000 10000 100000 1000000 2RNA 79 JP WO2003 100422 2003 RNA 5 8 amp 100000 10000 1000 100 23 100 1000 10000 100000 1000000 1RNA 25 CCCCNNCNNN 12 80 JP WO2003 100422 1 2003 12 4 81 00000000 INTERNATIONAL SEARCH REPORT International application No 2 03 06677 CLASSIFICATION OF SUBJECT MATTER Int Cl GO1N33 53 C12N15 09 C12M1 00 C1201 68 According to International Patent Classification IPC or to both national classification and IPC B FIELDS SEARCHED Minimum documentation searched classification system followed by classification symbols Int C1 G01N33 53 C12N15 09 12 1 00 1201 68 Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched Jitsuyo Shinan Koho 1922 1996 Toroku Jitsuyo Shinan 1994 2003 Kokai Jitsuyo Shinan Koh
44. 208248 427073 10 20 30 62 JP WO2003 100422 Al 2003 12 4 208030 224231 207958 217853 3931 2267 3816 2050 3797 1976 3720 1908 303468 416943 98281 381027 281849 392157 RL RNA 303841 425132 RL 294882 Em RL 273926 E RL 326722 RL BNC EE C a_i GP 30000 30000 A GP et GP A TRNA 25996 28105 GP A TRNA mes GP RNA 29840 26487 GP CATRNA 40246 37926 40246 37926 LP CA RNA 23499 26666 LP A TRNA 21181 23396 LP CA 18898 16579 LP A 19904 21535 24047 _ 25662 28475 27096 63 22405 24099 JP WO2003 100422 Al 2003 12 4 5 5 GP3 IGP3 Cy3 Cy 5 REE 10 20 6
45. 4 JP WO2003 100422 Al 2003 12 4 dl 1023 14746 13403 4550 1 65 JP WO2003 100422 Al 2003 12 4 16S rRNA 383740 504978 0 760 mitochondr ial 168 rRNA 394577 548290 0 720 376901 510288 0 739 E 380736 514505 0 740 5974 a 304449 331847 0 917 332066 367180 370198 0 992 289854 311660 0 fi 342079 3526921 0 970 17749 20992 0 846 ni 19692 mitochondr ial 168 rRNA mitochondr 22647 26804 0 845 13626 15970 17784 22114 1221 e co 1312 172 339266 388639 31974 328093 362272 3 9411 ferritin 311338 343969 17058 light 10 20 30 324108 1 020 369579 0 750 45773 274409 0 967 51062 315013 905 11147 336248 TT 103715 8 103630 91889 96876 99277 82909 1 197 iseiz s o 101407 e 10 20 30 329645 445141 350411 494950 10 274424 365659 306137 402541 I 3353 1594 2 104 _ 113 3441 1551 gt I 1601 220 asal 2 267 sl GAPDH 244109 317853 0 768 5660513 222019 1245685 GAPDH 222898 285042 0 782 21815 217638 243884 0 892 22177 30 GAPDH 225521 208129 1 084 55635 188698 236196 0 799 15424 208757 247356 0 844 16835 40 208030 s r de
46. 439 27269 TETTE loas la 31213 RL RNA RL RNA 10 RL RNA RL RNA Fo O O GP 20 S 14 2 HB 818 30 LI LI II II II II II II II II II II II II II II II II II II II II II II II II II I L LL I I I II II II II II I II II CL LI LI I LI MI II II II II II 1 II II II II II I II II II II II II II II II II II II II II II II II II II II II II LI LI II LI MI II II II 1 II 1 II II II II II I II I II II II II II II II II II II II II II II II II II II II II CL LI LI II LI MI II II II II II II II II II II II I II II II II II II II II II II II II II II II II II II II II II II LI LI 9 LI II II II II II II II II II II II II II II I 1000000 LI LI LI II LI II LI II II II II II I II II II II II II II II II II II II II II II II I II II I CL LI LI II LI II II II II II II 1 II II II II II I II I II II II II II II II II II II II II II II II II II II II II 50 JP WO2003 100422 Al 2003 12 4 50
47. 5 65535 65535 18507 23122 14375 e e E 1545 lt gt 29494 ID b gt Q 2 fe w CO n2 Ha lt DI 6553 27493 65535 65535 22304 25444 29814 28221 17126 23413 1346 1284 1322 1215 65535 65535 83374 19305 26214 3441 3347 3660 4235 65535 65535 38920 22473 31518 1670 1755 1960 1616 65535 65535 10 20 30 43 JP WO2003 100422 Al 2003 12 4 Ferritin light chain 34302 26104 65538 65535 65535 65535 ferritin light chain 35709 24118 65535 65535 65535 65535 30559 28048 65535 65535 29224 20825 65535 65535 65535 65535 Ius Pisto ribosomal protein ribosomal protein 81400 23901 65535 65535 65535 65535 31401 25518 65535 65535 65535 65535 ribosomal protein ribosomal protein c 10654 7871 65535 65535 655 5585 65535 11584 7865 65635 ll ui 10124 7352 eee 38607 37562 65535 65638 65538 _ 65636 ss ens sud 2294 ribosomal protein L35 ribosomal protein 56 ribosomal protein 56 30235 27750 ribosomal protein 56 33729 30549 13 kininogen kininogen 138 kininogen 101 kininogen 109 19 90 N C2 tr LN 10 20 30 GAPDH GAPDH GAPDH GAPDH thymosin beta 10 thymosin 10 26895 24558 23979 20790
48. BEF BIX PERBERE 00099000 Cy5 ni 2 f Y 8 3 SA 2 m N 2 Q 3 lt 3 2 5 5 Eom SA 3 RESSE 18 1 3 lek rere K 4 A e Nk E k BWR TE OU CMS RES Z REC CC 5 gt RR ER ox dg 2 1000 3 4 _ 5B 1 1 1 _ 1 2 3
49. e application but cited to understand the principle theory underlying the invention document of particular relevance the claimcd invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone document of paiticular relevance the claimed invention cannot be considered to involve an inventive step when the document is combined with one or mare other such documents such combination being obvious to a person skilled in the art document member of the same patent family Date of the actual completion of the international search 19 September 2003 19 09 03 Name and mailing address of the ISA Japanese Patent Office Facsimile No Form PCT ISA 210 second sheet July 1998 Date of mailing of the international search report 07 October 2003 07 10 03 Authorized officer Telephone No 82 WO2003 100422 1 2003 12 4 AR 3 06677 A I P C Int Cl G01N33 53 C12N15 09 C12M1 00 C12Q1 68 HETE gt KAT Int Cl G01N33 53 C12N15 09 C12M1 00 C12Q1 68
50. o 1971 2003 Jitsuyo Shinan Toroku Koho 1996 2003 Electronic data base consulted during the international search name of data base and where practicable search terms used C DOCUMENTS CONSIDERED TO BE RELEVANT Relevant to claim No 1 51 Citation of document with indication where appropriate of the relevant passages Category JP 2001 41892 Co Ltd 16 February 2001 16 02 01 Hitachi Software Engineering JP WO2003 100422 Al 2003 12 4 amp EP 1116949 A WO 01 042512 A 14 June 2001 14 06 01 amp JP 2003 516166 A WO 01 040303 A 07 June 2001 07 06 01 amp JP 2003 515328 Further documenis are listed in the continuation of Special categories of cited documents document defining the general state of the art which is not considered to be of particular relevance earlier document but published on or after the international filing date document which may throw doubts on priority claim s or which is cited to establish the publication date of another citation or other special reason as specified document referring to an oral disclosure use exhibition or other means document published prior to the international filing date but later than the priority date claimed INCYTE GENOMICS INC ISIS INNOVATION LTD See patent family annex later document published after the international filing date or priority date and not in conflict with th
51. u n n nmm r1 r1 r1 r1 10 20 30 50 13 JP 2003 100422 A1 2003 12 4 10 20 30 50 14 2003 100422 A1 2003 12 4
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