Home

附属書

Contents

1. Fe
2. A9 1 7 1
3. A9 2 A9 2 1 w e EU GESAMP IMO
4. 3 E OS m
5. A9 7 5 4 2 Imm ME A9 7 5 4 8
6. A9 7 Si A9 1 16
7. 478 A9 3 2 ARORH E A9 3 2 1 XF A9 3 2 2 gt Ne EEE bD
8. b c 1ml 103 106 d 5C 25C e 28 A9 4 2 4 6 att
9. OECD 1995 2 8
10. a gt ALEUT LEC
11. 458 3 CHS UPC 8 460 A8 1 GHS E 8
12. A9 4 A9 1 13 A9 5 BCF QSAR A9 1 14 QSAR
13. pe Seats H kre WH ee a ah fi uy PE cay a re 3 ia Lu 3 H 3
14. ua A6 5 4 A6 5 5
15. LOL RR A9 3 A9 3 1
16. 4 3 aA 20 25C W 35C 0 100C 10 830 10 de Henau 1993
17. 487 A9 3 1 eet ued Large
18. 310 A3 2 1 1 2 3 4 5 P101 P102 P103 K A8 2 2
19. A9 5 3 2 2 EJE
20. 457 3 1 2 XXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXX XXXX XX XXXX XXXX XXXXXX 2 4
21. A9 1 6 1 To
22. a b c 418 d pH e f g h i Q k m n 0 n p r SDS SDS A4 3 10 10
23. 1 C lR ww 6 4 0 5m PEE 1 1 8 T 1 1 100 7
24. 4 4 pH pH pH 6 8 5 pH pH 5 6 Scow 1982 an Wh lt pH 5 8
25. A9 2 4 A A9 2 4 1 ET E 1 a b L E Cs0 c NOEC EC d A BCF g og Kow
26. i 1 E NE SDS EE E
27. European Commission 1996 3 PC 2 3 2 CLOGP Daylight Chemical Information Systems 1995 Hansch Leo Hansch Leo 1979 C HY N O P 8 log Kw log Kow
28. GHS 11 440 A6 3 6 H
29. 519 o lt
30. SDS A6 3 2 3 11 A6 3 3 3 4 6 7 8 9 SDS
31. yaya ME WR oe 438 A6 1
32. 1 2 3 4 5 P222 H 2 9 1 H 2 10 1 P223 2 12 1 2 P230 2 1 1 1 1 2 1 3 1 5 RE E PF IERT O E XR ZK RGPS PRIZE Y IEE RERIT GE P P231 2 12 1 2 3 P232 2 12 1 2 3 P233 2 6 1 2 3 3 1 1 2 3 mn PIERA GIL SUBESIEA 3 AUPBIELTEEE CHEGE 3 8 8 HHEH 3 8 P234
33. 4 oma BAK BROMA REE MAL DED a i SAL Me gt o PEERED SREMEM E BLUS AOMEN NAN a ee ee eee te ie awe
34. H HPV OR HED 1990 IUR
35. R q CE Fy 490 ISO 9509 f E 2 100mg 1 E OECD TISO 11348
36. E 5 SDS 5 A4 3 11 11 A4 3 11 1 A GHS a b c d e O g h G
37. 517 A9 7 1 YES L E Cs0 gt 100mg L _ L E Cs0 EE L E Cso A9 7 5 1 NOs ARN YES 24 e o a L R Cso ORLE RIC ODRIH 7 NO YES YES L EDCso
38. Beak HE GHS P101 een P102 P103 GHS A8 8 4 A8 8 4 1
39. 2 b 2 AG6 5 10 2 5 HRS SET AA CHS 2 A6 5 10 3 5 2 a A6 5 11
40. 430 a E IS nara gees tae A5 2 2 6 GHS 8 KERIB LS LEB ES
41. 7 8 SDS SDS SDS a SDS SDS
42. 3 7 4 OECD 1999a OECD 1999b 2 OECD 3 8 ERMYH
43. 2 3 3 1 BROZORE 8 1 1 2 100mg l1 10g g l OECD 1995 g 1 gt Scow 1982
44. 1 2 3 4 5 P380 2 1 2 1 1 1 1 2 1 3 1 4 1 5 2 8 A B 2 13 1 2 14 1 P381 2 2 1 2 P390 2 16 1 P391 4 1 1 4 1 1 2 oa 3 1 1 2 3 P310 3 10 1 2 oe
45. 1
46. TEM pH wm f B a 3 BODzCOD A9 4 1 2 fz 4 1 E 1 H nt EH A9 4 1 8 FF ORLA A9 II A9 4 2 2YEIEF 2 OER A9 4 2 1 lt URZMELE
47. 2 2
48. A9 8 A9 4 A9 5 A9 1 9 a
49. pH el 2 7OFE 1 Organisation for Economic Co operation and Development April 2001 551 OECD Environment Health and Safety Publications Series on Testing and Assessment No 29 Environment Directorate A10 2 2 A10 2 2 2 ROH BYL PHEO RZ Y TRE BPEL AD A10 2 2 1 RAVMESEVLADICRIL TIL
50. 104 108 HI RIB AKA GIL 103 106 2 7 2 AREA mgC L E OECD 1995 amp 1mg l
51. A4 3 16 16 SDS SDS SDS 1 15 a SDS SDS SDS b SDS c SDS MER SDS I XBEBLELOGE CH ERBOU SR SEERAUZ GOS ESRT D 1 Ey h YFIR ER KATH BIES NE TY OERET SMAICST EE h
52. BILEH E PTEE LOE 4 Tm BARA L BUS UC f AE ALO E RI OKEBIEFS 2 BL OBES 2 DHA oe PE AER EEES gt E Jd EDD E rice i KRE T
53. 1 E 4 1 g E HEO 3 eaten oo V9 IR
54. 3 A10 6 2 2 Img 28 A10 6 1 A10 6 2 rs EG AR A10 7 A10 5 2 1 a b c d e f g h i Q H pH A10 2 3 2
55. me OECD m HK E sete 1 477 d PHR e QSAR QSAR O BEY CaF 3 1 ee es a Spe
56. LC 1 E XE HF X L E Cs0 L E Cso 2 h ED RAID MA LOVY Cal 1 At E 3 E 3 4 516 NOEC A9 7 5 4 TE E RI A9 7 5 4 1 _
57. A9 4 3 4 REPRE E f HEL FOTO WE ee Oh a A 1 HA E J 495
58. 1 2 3 4 5 P501 2 1 1 1 1 2 1 3 1 4 1 5 2 6 H 1 2 3 4 2 8 A B C D E F 2 12 1 2 3 2 13 1 2 3 2 14 1 2 3 2 15 A B C D E F 3 1 1 2 3 4 3 1 1 2 3 4 3 1 1 2 3 3 2 1A 1B 1C 3 4 1 1A 1B 3 4 1 1A 1B 3 5 1A 1B 2 3 6 1A 1B 2 3 7 1A 1B 2 3 8 1 2 333
59. SDS A4 8 11 10 BIEDEBOEIE GIEBIEDHEE ZL A4 3 11 11 HAZEA A4 3 11 12 REOUL FHT 2BLUGS
60. A4 3 11 5 A4 3 11 1 iu oe a a s A4 2 2 3 E i gt wee Tea A4 3 11 7 THEOD D SIT lt BIERO FX
61. P264 P270 394 HEE lt E 3 8 B 3 H335 H336 P261 P304 P340 P403 P233 P501 DUANE AIS A RRRIAT VU ORARHE
62. 70 EME OD BY He E 16 MOTRA T E RRETA DIAK ASSE D A9 4 2 4 7
63. MERRE OECD log Kew 8 2 K OECD Guideline 1998 n LC log Kow 0 6 HP HPLC Log Kw USEPA 1985 Kow
64. E 34 w E BOL ICO CBU E L E Cso 1 HH FE E F
65. WSF 3 4 1 A9 3 5 5 H RT RRE E EN EDHI 1 E 1mgl
66. A4 3 12 3 A4 3 12 7 A4 3 12 2 A4 3 12 3 CNC PRE ORE
67. H 443 A6 5 6 Hk LOMAFE A6 5 6 1 _ A6 5 6 2 A6 5 6 3 A6 5 7 11 3 6 D FI RR PFE A6 5 8 KM A6 5 8 1 SDS rt IE WET AD
68. a b c 2 2 1
69. az 515 A9 7 5 3 2 2 BREE A9 7 5 3 3 RAFF lt L E Cs0 24 A9 7 5 3 3 1 L Cso a b c L E Cso 1mg l L E Cs0 1mg l 10mg l L E Cso AS
70. 3 lt Rp PE log Kow QSAR
71. 419 A4 3 10 3 RAF Leis TELE ERAEN BIZ Daes A4 3 10 4 BUSSES A4 3 10 5 ARFEIL Oe ms J FF X LN E HFA FA A4 3 10 6 FELDER 4 1 FAP E
72. 536 9 V 1 a EC guidelines Comission Regulation EC No 440 2008 of 30 May 2008 laying down test meshods pursuant to Regulation EC No 1907 2006 of the European Parliament and of the Council on the Registration Evaluation Authorisation and Restriction of Chemicals REACH b ISO guidelines ISO http www iso ch c OECD guidelines for the testing of chemicals OECD Paris 1993 http www oecd org env testguidelines d OPPTS guidelines US EPA http www epa gov opptsfrs home guidelin htm e ASTM ASTM http www astm org standards 2
73. A3 2 3 8 2 P280 A3 2 3 4 2 3 P241
74. Teri ee RO OSONAIL lt BIBL OS 1mgs 1 IT lt GIR EEO HERR es
75. 2 SN ZIR E FE OFFA AHL Ae H Weer L BAN Taw OECD H 1 SF
76. 4A9 3 3 2 2 cH Rh E log K 4 BCF lt 500 E EH va EE
77. Veith 1989 A9 6 3 5 LT NO CR a mitt QSAR 34 Mikike LTE E
78. 1 2 3 4 5 P310 3 1 1 2 3 BERRE 3 1 1 2 3 1 1 2 3 2 1A 1B 1C 3 8 1 3 10 1 2 P311 3 1 3 3 4 1 1A 1B 3 8 1 2 P312 3 1 4 3 1 5 3 1 3 4 5 3 1 4 3 1 5 3 8 3
79. CNS OR ANSI A8 3 2 A38 3 2 1 A3 8 2 2 ra f E E E H
80. EERE OE a b am iG 3 CHORE CC ABER A A9 3 5 7 2
81. A3 1 1 2 GHS A3 1 1 3 A3 1 2 A3 1 2 1 a SMS UH hazard Statement b 2 3 4 RRA EE c
82. DRE A9 4 4 HEXF A 1 1 1 H EIE E
83. A9 2 Do A9 1 8
84. GHS 4 3 1C 1 4 A8 2 1 1 EINECS EINECS IUPAC CAS No 999 99 9 EINECS No 222 222 2 1 2 2 SO 1 3 CxH 0 1 4 1 5 w w 1 6 1 7 TX Globalexyl UNoxy ILOate HE PILZ YP 461 A8 8 4 2 1 2 2 146 2 2 8 CO 45 24 CO 208 3 2 5 2 6
85. LAL KER 4 2 5 Scow 1982 26 AVL Scow 1982 E
86. BCF 502 E VLE E 2 E A9 5 3 2 8 BCE Kov DZ RODNE BCF A9 5 8 8 BAREO WAP L ORAWA 0 S
87. SDS 2 8 E A6 5 8 2 cH ED wy ABM EZ A6 5 8 8 et A6 5 8 4 BAIS S amp HT Ze
88. c log Kov L B Cso NOEC 2 A9 3 5 9 AREKOZLY A9 3 5 9 1 pH pH 1
89. A2 17 3 1 era 1 LD 5mg kg LDso lt 50mg kg LCso lt 100ppm EEE LCso lt 0 5 mg l GKE LCs 0 05mg l pee zii 2 LD 5 gt 50 mg kg LDso 50 gt 200 mg kg ER OEE LCso 100 gt 500 ppm LCso 0 5 gt 2 0 lt mg l GER g rears LCso 0 05 gt 0 5 mg l HF AE MEE Ab 3 5 LDso 50 gt 300 mg kg Gps LDso 200 gt 1000 Smg kg ba LCso 500 gt 2500 lt ppm pte ee 5 LCso 2 0 gt 10 0 Smg
90. A9 2 4 2 A9 1 10 A KOD R CH SBI AN SNS AED ERI ONS WEO RRE
91. a b c d ec g A10 5 2 2 OZ pH HORE A10 2 3 2 A10 5 1 6 pH IMAC ZAYED pH A10 5 2 3 A10 5 2 3 1 ae A 5 A10 5 2 3 2 ya IL Aas BEF 2 ORGY 3 2
92. 422 A4 3 12 4 FERHE E PREFE FIER A4 3 12 5 462A 4 Kow BCF A4 8 12 6 tBPOBHLE thal FOA K IRIE a4 E A4 3 12 7 MOA SEE HEE LA
93. A9 6 4 KERBASHEAH O QSAR DEHA A9 6 4 1 a b c d e LT E BCF A9 6 4 2 ay f He QSAR QSAR QSAR
94. GHS 1 2 3 4 H200 2 1 H201 2 1 1 1 H202 2 1 1 2 H203 2 1 1 8 H204 2 1 1 4 H205 2 1 FH 1 5 H220 2 2 1 H221 2 2 2 H222 238 1 H223 2 3 2 H224 2 6 1 H225 2 6 H 2 H226 2 6 3 H227 2 6 4 H228
95. P220 P221 EHA P280 pi S P283 P371 P380 P375 P370 P378 7 SKB RA EHKE LEGGE 361 2 13 B HEOK
96. A3 2 2 3 A3 2 1 A3 2 2 A3 2 3 A3 2 4 A3 2 5 A3 2 3 A3 2 3 1 5 1 2 3 GHS 309 4 5 A8 2 3 2 2
97. Dae CO ee ee a b c 28 16 gt 0 048 day I
98. QSAR QSAR CO KE FR n E E 3 2 To E Hipnick E
99. 1 AROW Z9 E 1
100. 3 Syracuse Research Corporation E BIOWIN E 0 5 OECD 1994 Pedersen 1995 2 8 67 Langenberg 1996 Q SAR H QSAR 6 N fo A9 4 2 4 15 EJE
101. P321 REPRAP FINALE EIT BRET SD P332 P313 P33884P318 BISNLLEMEBS E XILHPRLT BRY P362 P364 382 3 2 2 3 H316 P332 P313 P3334P3138 ZF NILE DB EX ILHMRLT X 383 3 3 _ vy Me 1 H318 P280
102. H RAE SONS MER lt TD ALC RIE STC i f Ea ia HE H GHS GHS ly A5 2 2 3 A5 2 2 5
103. E 100mg 24 24 A10 2 8 BYL BMFOREMAR ESAI L EG EERIELS A10 2 3 1 IZON 7 J 3 A10 2 3 2 pH pH 8 5 pH
104. 2 25C 4 gt a 5 De Bruijn 5 1989 ESL EEE T E nm log Kow 4 5 K Control Act Test Guidelines USEPA 1985 531 2 8 log Kow REDE MOOD QSAR Of 49 6 QSAR PHI BB D E 2 3 1 K QSAR
105. a A b BH zr LZ i UON c 2 EU USEPA
106. 1 WILL ae 7 336 A 2 A3 3 4 6
107. PE BIZIED BRE TCILY AZ wi E H 2 A Z yy
108. a b A9 4 2 4 8 492 OECD 3802 70
109. ym P305 P351 P338 o P310 384 3 3 SB 2A H319 e P264 P305 P351 P338 P280 ym S
110. Sk FAA 2 8 10 A6 2 6 8 11 1 4 1 9 De alert K A6 2 6 9
111. b 2 8 2 3 8 c 9 2 9a d 10 2 8 saat 9 o 11 ij e 11
112. ADI E lt RE 100 1 431 CPSC 10 11 12 ILO 1999 Current Sector Uses of Risk Communication IOMC ILO HC3 99 7 A Venema M Trommelen and S Akerboom 1997 Effectiveness of l
113. 2 a 2 3 2
114. To E L OECD 1998 E E 3 2 lt BREE OE ee ea eae aa gt a ae K HERR EE BLOM OX BEAR WS biomagnification European Commission 1996 E E
115. BCF a ae Zs Sa i EE gt o gt E Ce A9 5 2 8 8 2 Zs 3 Br A E AIA J Ay eM 1 BCF See E BCF BCF E
116. NAS 6 E RARR THA A9 2 3 4 4 1 4 1 2 11 3 A9 4 2 9 SAAMEM A9 4 2 2 1 OECD E f
117. SDS 421 A4 3 11 13 A A4 3 3 2 1 ce GHS 1 3 2 3 A4 8 11 14 BAOSRAGR A4 3 11 14 1 A4 8 11 14 2 a
118. A9 3 6 2 2 Pedersen 1995 US EPA AQUIRE Mensink 5 1995 Pedersen o eee Ho Fe Foe AL by BSFA Ritz A9 3 6 2 8 AG LL 2 OBR CT f GLP ERROME FIC Fe haf FAST Cx net A A a A9 4 A9 4 1 A9 4 1 1
119. Bruijn 1989 QSAR log log Kow Overton E DE FELDER L DERRE QSAR QSAR PINE A ee a RU Coe Oe
120. v 3 A9 6 4 4 EPA SIDS US EPA 1999 He Ti 1 1 I SHEE SVS HPV Cie Le
121. 1 4 10 5 2 d 1 4 10 5 2 a 1 4 10 5 2 b 1 4 10 5 2 c 1 4 10 5 2 e BFR IERIE LEME ORRUA LEERY OW ELE DIT SS LNA IEDZ ILAVIEIKOMAERIL WIEBE GHS ATA CHATS amp BCE SB 452 3 2 2 A p GHS AS 0 OO le 1 4 10 5 2 d 1 4 10 5 2 a 1 4 10 5 2 b 1 4 10 5 2 c 1 4 10 5 2 e EPL BRU GAC MEESTE o CILSERBAC GHS FNL EERIS EBDS 453 Bl 4 2
122. 486 WSF E WAF L E Cso LLso WSF WAF A9 3 5 10 2 E
123. Van Dem Berg 1995 Wofford 1981 3 ATEI ke log Kow BCF Spacie Hamelink 1982 Gobas 5 1989 Petersen Kristensen 1998 Connel 1990 BCF log BCF log Kow J i a
124. A4 3 11 8 QB FIIR A OE FIIR BRET SEK oe v A4 3 11 9 B L ORANE BCL OEE EBB O OBEN EE
125. FACIL ED OE 488 A9 3 6 A9 3 6 1 F 4 DADER Jot Be E LR A9 3 6 2 A9 3 6 2 1
126. ZO SN Rea aie TEREN Al Da Beng rata pepe ae ACRE SU 7 BE y KEE ee ee chronic aquatic toxicity A9 2 Ay BRM
127. 4 4 1 4 2 7 S Scow 1982 a
128. A9 7 1 5 A9 7 1 6 A9 7 4 EDZE A9 7 4 1 log Kowt A9 7 4 2 A9 7 4 8 BCF 4 BCF gt Kin BCF 4 pe An 1 2 Ee ay
129. DAM R Ca S E LCso HH 7 N wm NOEC 481 NOEC NOEC NOEC 4 H A9 3 3 2 4 Lemna a b c EEL tt D OR 1mg l Hv 3 A9 3 3 3 lt Bye
130. ao EE A6 4 1 2 1 2 A6 4 2 A6 4 2 1 2 11 EME Ej A6 2 A6 4 2 2 Do x F nT 2
131. P312 P321 AFD VEPRO 9 CRAE DURARE P361 P364 374 3 1 B 4 H312 e P280 P302 P352 P501
132. KIY KZ EHIK AH SEE 356 2 10 1 H250 1 P210 P335 P334 P422 DOR P222 P280 ym S P370 P378
133. P264 P270 P321 FR EADIE N ME BL ERG 393 HEE lt E 3 8 B 2 gee H371 lt lt gt gt lt gt lt gt ICI BL DPAPULI COREE ZS OMER EAS S lt lt gt gt Z MORD OIF S BEDRA CLAW 2 EBR EHC AE SHWSEGE HECE ERREI O P260 P308 P311 P405 P501 13 REEI ROMSRH OBS
134. A9 7 aa i AR OECD No 301 OECD 1992 E A9 4 2 2 2 OECD 209 TE a s
135. pE m BCF E E H Ti JE E f A9 7 5 BABEURRE BAT ERAZO A9 7 5 1 A9 7 5 1 1 amp 4 Be cea A9 7 5 1 2 es r E
136. P312 P321 AEN ORAAD E F LE AMEBLELEGE P362 P364 375 3 1 BL 5 H313 P312 376 3 1 B 1 H330
137. alae TECHS 6 N A9 5 3 5 2 A9 5 3 5 3 ee ga at E BCF BCF Kow
138. log Kow log Kow QSAR EYE A9 5 3 4 A v MP CSTEE 1999 CARD By REM A9 5 3 5 ZRIENE TERI A9 5 3 5 1 JH Ho ae European Commission 1996 E E
139. 522 3 7 tBRLUEE PODM 3 7 1 OECD 304A OPPTS 835 3300 3 7 2 a b c 3 7 3 OPPTS 835 8180
140. DERAF 9 pe HH A9 2 6 2 1 Be A9 3 6 2 3
141. 372 3 1 1 H310 2 H310 P262 P302 P352 P405 P501 AR RE ERICH RVC E P264 P270 P 280
142. A9 4 3 5 ZYV L 7RHRCOPET SIGE A9 4 3 5 1 1 a 3 1 E A9 4 3 5 2 a b c d e A9 4 3 5 3
143. A9 3 5 8 REE TICHET 3S COMDZEH a NN L E Cio NOEC JE b W NN ete ie Conn clas
144. fm BERN GHS 3 4 3 E BO
145. A9 7 1 3 y A9 7 1 4 yay ao Na l CORA TR Bet 2 ECLA HEAR IC
146. H E uh E 10 snti BODs
147. ee ee en A4 3 3 2 2 a b A4 3 3 2 3 teat EE EE HA 1 PCPI BD ORE FIALAD FRA E ERT D 413 A4 8 4 4 X CHS E lt RK ABORT SHARDS A DARE
148. 24 pH 1 A9 7 2 1 2 8 A9 7 2 2 4 pH pH 100mg 1 TEE 10 3 FY pH E TRH 10
149. 292 A2 28 a 4 1 Ue 32 SG L E Cs0 21mg l L 2Cso 96 LCso 48 ECso LCso 72 96 ErCso 2 4 1 3 4 3 Si aa BE a he lai Cisse eee I 1 1 x M 2 25 M 4 1 3 5 5 5 1 b SN is 4 1 8 5 2 4135 38 Mereside 1 LCso 1mgI c 4 1 3 5 2 4 1 3 5 5 8 1 1 x M 25 4 BERTO J b 1AL
150. lt oo TT RS wren La WOR a t e ON E 9 ELTE A9 7 1 8 1 3 A9 7 1 9 a MO
151. 1 hj E E gt 529 OECD 305 1996 ECETOC 1995 1 BOTF 7 gt k F ko EEr 7Zzz BCF As
152. 5 6
153. ese Io A9 6 4 8 4 PER EOE E OECD OECD 1995 eva er SES ECETOC QSAR LUBY SALA TET LCS QSAR l 7 ECETOC 1998 SHED Te fea F
154. 1 2 3 4 5 3 1 1 2 3 08 BERRA Ee SKE Boag exes 3 EA EW BIE LEHET 3 8 HEGRE 3 3 8 P403 2 6 1 2 3 4 po CSS 2 8 317 A B C D E F a Ht oko LL BAORV YA CREST SO 2 5 VETER Hi BE FLA P403 vat AO A EIGAR P 200 YEMR A A BoCW SERA RY Y VHP HRB AR WSF BIVZITHR LTH RU EE BV PREPIR FDEZ AT FRALHE BUT OSLO DIRE SRV BGAICIRS re 509C 2 3 1 2 3 P412 P411 0C 2 15 A B C D E F ermal Keer 332 A8 2 5
155. 2002 WSSD GHS GHS 4 GLOBALLY HARMONIZED SYSTEM OF CLASSIFICATION AND LABELLING OF CHEMICALS The Globally Harmonized System of Classification and Labelling of Chemicals GHS has been developed through cooperation between the International Labour Office ILO the Organization for Economic Co operation and Development OECD and the United Nations on the basis of a mandate given in Agenda 21 by the 1992 United Nations Conference on Environment and Development UNCED in Rio de Janeiro The GHS addresses classification of chemicals by types of hazard and proposes harmonized hazard communication elements inc
156. 370 3 1 4 H302 P264 P301 P312 P501 P270 P330 371 3 1 BL 5 H303 P312
157. 4 f M E g if A TX a DPN FLAG Hd FID sep 3 AUS 1 4 FE sec Og H HL TWS DRY E E KE NOEC
158. PPE PPE ee A4 3 9 9 A4 3 9 1 A4 3 9 2 Fy E A A4 3 9 3
159. E A9 7 1 A9 7 3 2 a b
160. a b A4 3 5 3 HBLAORWLGS EF BBE A4 3 5 3 1 414 A4 3 6 868i TERA A4 8 6 1 An DFPMBE BDA BLGAMBE A4 8 6 1 1 RAFBEAOS LT
161. E 4 QSAR 1 E os ite a Oe E 96 LC50 n ah lt WHIT La k TER E E Me
162. 1989 Tolls Sijm 1993 OECD draft Guideline 1998 REHE 530 E QSAR tA E E De Bruijn OECD 2 2 2 FAX RRE 2 n 1og K 2 n 10 2 2 3 HPLC HPLC Wt GAO bef 6 2 2 4 MEFE 1og Kow 8 2 K SAN cae St raat eee GAN Ie tae t
163. 441 BES ROE ICHAEL TRO ETC DA E mee A6 4 2 3 A6 5 A6 5 1 GU CS OEIC 2 11
164. Bil 2 2 FA CHAK CHA SDS 1 DUKE
165. kek erue mn ADEE 11 ORAMO TSF ER 1 nin RRO wet ab i 1 1 65 11 1 1 2 rer ee A2 14 2 14 DO a or SPRINTS BI ane ER 8 2 4 1 E 1 1
166. ines ES FY EDEL MI ere Fa o A5 1 4 3 A5 1 5 eae ee o o GHS 1 w Tez ay 1 EF 1 EFA KAA HVS RE o AAE ARS
167. A3 1 2 GHS 1 2 3 4 H300 3 1 1 2 H301 3 1 3 H302 3 1 4 H303 3 1 5 H304 3 10 1 H305 3 10 2 H310 3 1 1 2 H311 8 1 3 H312 3 1 4 H313 3 1 5 H314 3 2 1A 1B 1C H315 3 2 2 H316
168. SDS 3 SDS MAIR ALE SIV TWH BENZA H A4 3 8 1 3 Kee j H SDS o A4 3 8 2 BWLIFHK FHL E ea ADA a A
169. a 28 DOC RER 70 3 b c VW d 3 2 10 14 16 4
170. we b REREN Reap EE 290 A2 26 3 9 di DAIL ORAT 2 Ob SBE 3 9 2 MS gt 3 9 1 E HAYIOT 2 BMF CE LUV GE RA II Coe ee DRE ORM BEA ANU BF DiBa ZERI ooo 1 i
171. 509 QSAR OECD 1995 BIODEG Hansch Leo 1995 Meylan Howard 1995 Hilal 5 1994 Howard 5 1992 Boethling 5 1994 Howard Meylan 1992 Loonen A9 6 4 12 QSAR SDAP L ORAS T B EK ALE
172. BCF 500 BCF log K 4 49 2 4 3 A9 2 4 5 ea Ree ES a age a acl Lal 4 BCF 500 BCF log Kow 24 4 A9 2 5 Pier F 2 OFS THEE lt
173. P310 7 P321 AFD VERANDO E J RRA DURARE P361 P364 373 3 1 B 3 H311 RIC HEARS SL Ae P280 P302 P352 P405 P501
174. a Tu ld El LAL ME ON TO CN ES I pH Gi A9 7 2 1 2 2 2 iS X EF IVD D WF yop Ft Y RIZDOVW COR AR lt Ae E BLM JOT A9 7 2 1 2 3 MTINTEQ Brown FOIZ CHESS Santore Driscoll 1995 pH DOC
175. P234 P280 ym S KRY AD EMK AUP EBGE P370 P380 P375 P411 C P420 353 2 8
176. LIMITED ABS HRT D ELIT MORD DIES BERETE OZ E BEHI HE HENTO OSHA A EIES BRB S R 6 LAMIE ABS HRT D HUD DS DI S BBH ETE VOZ E DAER HE HARWSEER F BLL S BEB E it x 4 LHAULIHBBO ABE RET B FIL HUD D DISS BBA CL WE E BR EHC AE BARWSEER F SLUTS BEB Se Ro x REKTAL ZE Melia L TEE ROOD iix BIT SME ETNA IRE ENTR 262 ENE S 1 2 8 gt 6 LHHISHE E 6 HNIT E BRIFTEL COM FZITELCOM HEL BTS HEL BTS CUDEBDRPS5OD MORD O IES BBAE TO ES BBE CH WOEBREMIC VZ E REKI BBARWSH ASUTOSH BR BERIS BRIE NABI BE Be we Be we EEE ROOD fix BIT BME CT ABIALCISBLIE SUTURE IE E 1 2 e BZZ
177. 1 GHS ZET 3 ERKI OO LADO E O Th B EIRA NEB ILO DEBRA EVE UB IEL YF 3 ERED 0 I FPR OV RKFOFRRHIF AI Lo CHB ENE 435 A6 2 5 SDS 4 A6 3 6 A6 3 1
178. 10 70 A9 4 2 4 4 A9 4 2 4 5 sk a gL
179. ve y 2 RT IO I E T A3 2 8 8 GHS P305 P851 P338
180. A3 3 4 2 BEDANI ArI E CHE SAAD MSIL EREBXOWMAOLOOERCHD IN A3 3 4 3 A3 3 4 4 JERSE A8 8 4 5 2 83
181. k gt 1n0 3 ln1 28 0 043 day ts lt In270 043 16 A9 4 2 4 3 A9 4 2 4 2 4 1 4 1 2 11 8 c 28 3 Q10 491 E 28 1 E
182. o P337 P313 385 3 3 ZL 2B H320 P264 2 P305 P351 P338 kK CRA o P337 P313 E 386 3 4 1
183. ORAZI H QSAR E 1 3 QSAR HARE gt ERA ZR rt JD H JER Mz i 2 489 o
184. BPE 1 471 ET OMA Sb HS OECD Environment Health and safety Publications Series on Testing and Assessment No 27 Environment directorate Organization for economic Co operation and Development April 2001
185. WW A4 8 2 1 F DE E RILEOORE A4 3 2 1 1 A4 8 2 1 2 GHS 2 8 4 TARET ERME OT Ee ES RN Az oe 1 1 1 Oe ASKU A4 3 2 2 ZEZE A GHS FS EBSF A4 3 2 2 1
186. 7 7 Ae We SH 248 1 Re ul Q K 5 1 YE BESS RDO Wre lz IF SME EPA ICES ORR 1 ee Wel 2 DRA DIKO E 249 1 2 3 4 ETER DR I BP
187. NZ LOGKOW log Kow Roberts Les PRS log Kow HE CO An a BCF 500 500 oe a Do BCF HE UT BCF A9 5 4 2 FFT S log Kow
188. f A5 2 2 4 37 Na t iB El NA Dik REO E BED I pana 3 1 GHS
189. E EE BONY BE BCF BCF E F T 1log Kow 6 BCF
190. HU TE F at A v s yH 1 L E Cs0 1 CO AK L E Cs0 L E 4
191. OT QSAR QSAR QSAR QSAR A9 6 A9 1 15 2
192. 557 15 7 20 Img l A10 5 4 BREF A10 5 4 1 20 23C 1 5C A10 5 4 2 A10 2 3 2 A10 5 1 6 pH pH pH 40 2 100mgl Ey pH 7 A10 5 4 8 8 5mg l 709
193. E 1 pH j FE 38 1 mgl 10 mg l 7 2 pH A9 7 2 3 KEBHES 2 E RIET 2 OL BE WFR RAAT AE DBP ORE 7A L E Cs0
194. 1 gt Tm zl A10 4 a b c d AEF RIR e E gcm3 552 E 9 ppm 28 H E 3
195. 2 log Kow 2 1 R E RHE 2 1 1 n og Kow log K log Kov K log Kw Niimi 1991 1 Henderson Tocher 1987 Kov WA log Kow 2 1 2
196. 100mm 140 C 25mm Z 140C 100mm 100C 275 A2 12 2 12 EZAR 1 1kg 10 ee ee
197. 4 1 B 2 TE Et lage L H401 3 PEE TAZE L H402 P273 P501 BEL MELIIAE 400 4 1 1 H410 2 TE lak a L H411 P273 P391 P501 LEE ZMELIIL 401
198. A9 5 2 3 9 4 BCF 1000 10 OT OECD 805 1996 BCF BCF 500 BCF BCF A9 5 2 4 KAEA Kow A9 5 2 4 1 K K
199. B E 3 EA BE LR 2 3 H 4 1 4 1 2 4 4 1 1 d gt 1 i o Sail 2
200. WO L Cs E 514 BBR E DEC BIT 3 DAME OBE A9 7 1 ZS 2 OF TEE mgA LE Cso L ROCso X NOEC A9 7 5 2 BOD BME A9 7 5 2 1 L E Cso 100m
201. 1 2 3 4 5 P334 2 9 1 CH Doe 5 2 10 1 2 12 1 2 P335 2 10 1 2 12 1 2 P336 2 5 P337 3 3 2A 2B P338 3 2 1A 1B 1C 3 3 1 3 3 2A 2B P340 3 1 1 2 3 4 3 2 1A 1B 1C 3 4 1 1A 1B eee HEE R 3 8 3 A ET 3 8 3 ee P342 3 4 1 1A 1B P351
202. 2 10 1 2 8 9 I ON faa A6 2 8 1 12 A6 2 4 A6 1
203. 4 E BCE E OR CR SA BCF F REL E 0 a 2 cI BCE
204. P270 P321 EE OMEGA ORGBLELBE P330 369 3 1 3 H301 P264 P301 P310 P405 P501 P270 P321 KEOGH ORG D BRR AR P330
205. D5 WAZ a 80
206. f gt A A9 2 3 3 A9 2 3 4 e KR a A gt E 1 ME 4
207. 1 1 5 i 2 10 Gai 2 3 2 10x 1 OFF 2 Dif J b 10 3 2 3 3 4 ge OF X w Hill 280 ORN VIKE A2 18 K GBRE FURIE GEL 38 2 BEE X ee 1 BAR URTZ DO BADHA 4 fe 3 2 OREO CYA 1 5 2 8 3 2 2 2 RYO 2BAFCALV GE O7FX ORE
208. A9 4 2 4 11 A9 4 2 4 12 Bl OECD 111 pH4 pH9 ts 16 NUM a ON g TEER 4 CRITZ OECD HERWEN Z o 72 AEE DAEBUZ OVT RRA FIENI BIT B EU OFFESEMLO fet LT OBB CAULKEWADEEBNE L 5 b SHOF 2 E TARE IMT
209. KIY KZ EHIK AH SEE 357 2 11 5 wy 1 H251 2 H252 a P235 P410 P407 P280 jm P413 kg C P420 358
210. OECD 1995 Nyholm Ingerslev 1997 2 3 a b c d y 525 2 4 3 az
211. ani amp aN BCF VT log Kow 9 498 ete IIT Kow 9 VD E Pt A9 5 2 EMRE Z DRR ae 1 A A9 5 2 2
212. 6 gt E EVE H E ISO 11 RTE DR BAY rai V eRe BEC MEER I OECD 301C 100mg l 301D BE bki ISO 9509 Ret AZ L CRM
213. 1 mm HOFA 1 mm A9 7 5 4 4 OECD 2001 Skeaff 2000 VI 5 RoT RESNE L E Cs0
214. A9 7 A9 7 1 A9 7 1 1 OECD 1998
215. A3 1 2 H300 H310 6 A3 1 2 4 1 4 10 5 3 3 2 A3 1 1
216. A8 3 4 7 1 4 4 1 amp 8 A3 3 5 A3 3 5 1 ZORIZ GHS A3 2 2 1 337 2 1 AR H200
217. A9 3 4 3 2 L E Cso NOEC A9 3 5 RNE A A9 3 5 1 23 4
218. H FE BLM Santore Di Toro 1999 OECD 2000 512 EA O TE 9 BOARS LOWE Allison 1987 E Al nl Ce oF T DEM
219. AY HH 9 A6 5 14 F4 BANY ZBL OE 446 JETP ME GHS 1 1 3 A6 5 15
220. E ub BX E HEREZA E E a 3 BCF lt 500 b wig 475 fel L E Cso 1mg l t YEZ E log Kow 24 L E Cs0 1mg l A9 2 3 5 F
221. 11 a 11 5cm 200rp m tk PVC 8mm K 350mm 40mm 15mm 2 b 1 0 3 01 100rp m kK A10 5 1 10 A10 5 1 9
222. a Ct Co kt mg l Co H t 0 mg C t mg l k mgl b KEF Ct A 1 e mg l Py mgl Ct t mg l k 1 c Ct A 1 e B 1 e mg l 558 x Ct a 1 b 1 C d t mgl AB mg l Ct a 1 e c n 1 be ne gt n b mg l N Q t mg l a mg l b ce d n cd S 7 8
223. pH E E pH pH L E Cso A9 7 3 RICP SAEI AT Z PE A9 7 3 1 SAL IDAHO CHS AKA
224. H Pedersen 1995 A9 4 2 5 PMF A BME CR LUGE A9 4 3 SERICDV CORK 22 A9 4 3 1 EHLYA 494
225. IA 1 4 Ln 4 1 1 1 3 7 1 2 277 A2 15 2 15 as EE RE BIT SHG PRI k OPEN A FEO RMERLY Y A A H wR 7 ESE RE TIT SOL PRT L OAE HA A H 2 15 2 15 4 1
226. a A H240 w ris P210 P411 P235 P501 BVA TEERAIRIEO DO OL I REAR DR P220 P284 P280 ym S 5C P410 P420 365
227. KBY AZ EHIK ALBEE P411 C P420 355 2 9 1 H250 P210 P302 P334 P422 BVA TERAIRIEO DOOL I REKHA DOR AM P222 P280 ym S MEOKECRT Z Lo P370 P378
228. SDS A6 8 4 GHS SDS SDS
229. VO SDS Do DAI Ni i m A6 5 9 HVFFOPRAE 0 1 0 8 A6 5 10 AX A6 5 10 1
230. EDEMA APs tu E ASH NE ns 4 A9 6 3 6 QSAR E QSAR A9 6 3 7 4 QSAR E Lipnick 1991b E
231. LE Cso gt 100mg 1 1msg l 4 1mg l 476 FE 9 2 4 3 1 4 1 4 1 1
232. PRAZA E ARR 1 Part 1 PEER 3 K A9 3 2 6 2 3 US EPA OPPTS 850 1350 1 BREE NED amp J VTE ALR gt A9 3 2 7 3 202 Part 2 He SE TAE J4 1 A9 3 2 7 1 1 3
233. 1 2 3 4 5 P501 E 3 fi fix E 3 3 B 3 9 1 2 8 10 1 2 4 1 1 2 3 E 4 1 1 2 3 4 P502 4 2 1 334 3 3 A3 8 1 X A3 3 1 1 GHS GHS a A3 3 1 2 GHS 1 3 2 2 1
234. NM See 2 AY BABES KHE 253 1 2 3 TEER ODI S Y S LIS 5 EFNA ANC KB CRRO ES Aa i 2 ER 5 1 1 2 8 EAB RO WIE es WIS 5G CFO AN E BEBROE ah gt 3 a Ee 5 1 254 A BAT B C D EEF G O BRBH4 CONT SG
235. eas em a gt 4 8nm BCF EE BCF 1H 1991 2 2 1 4HADKES Wy F V MEAS H
236. A4 2 5 2 A4 2 4 2 SDS 7 SDS A4 3 16 A4 2 6 ST 1 A4 3 SDS SDS GHS A4 3 1 1B A4
237. E 473 E A9 1 11 A9 3 A9 1 12
238. BAX III E H ED BCF BCF ASTM E 1022 94 1 gt as nee BCF SS A9 5 2 3 8 A9 5 2 3 8 1 BCF BCF
239. PPE SDS 5 Pac P nen PPE H E ME at ORE
240. OECD No 11 ra 0 1 5g 96 E 96 2 0 te Re OECD Jo A9 3 2 5 2 RAZ eh OECD E EPA 850 1500 3 7 yA 210 4 200 E H A9 3 2 6 A9 3 2 6 1
241. 0 PAE A9 3 4 2 GLP GLP GLP hH
242. 5g 31 2 E A5 2 2 7 NOAEL
243. 4 1 1 H401 4 1 2 H402 4 1 3 H410 1 4 1 H411 2 4 1 H412 3 4 1 H413 4 4 1 H420 4 2 1 307 308 3 2 A3 2 1 FRX A3 2 1 1 1 4 10 5 2 c
244. 483 b d e A9 3 5 O A9 3 1 A9 3 5 A9 3 5 6 t PARR CELER S eM c Et E 4 JZ E
245. E LESERONBEIZ LTT SE AB ISL OME ALE FS BORER VU I ANH 2 15 2 15 4 1 OF ESE AGRE TS PRI L OHE HAA BIROR Y R A H 2 15 2 15 4 1 PO ee ee ee J FL A H O RA FET 2 15 2 15 4 1 NNER EROPEILALU Jo A2 16 2 16 55C 1 6 25mm 278
246. 3 1 1 2 3 4 1 1A 1B DXB 16 Flt DLE AAFIL GT DIENT PROS RETNA OD Fe DIZ IBROZL A ZEAL T WEGNEAL TERY eee 2 12 1 2 3 P232 me 2 11 1 2 P410 318 K A3 2 3 1 2 3 4 5 P301 3 1 1 2 3 4 3 2 1A 1B 1C 3 10 1 2 P302 4 2 9 1 3 1 1 2 3 4
247. A6 5 11 1 A6 5 11 2 A6 8
248. DE QSAR n log Kow BR DS IK 507 A9 6 4 8 2 QSAR
249. LAS HIER LOC ORB DP DR BKEOG ity a 340 2 1 ZL 1 5 H205 P210 P370 P380 P401 P501 BKIK EOD DO ODE IRAK POR P230 PLES LEAR TE RIEL GA ELRE PEUZ LO IRISA RIEDR HT AG A he P240 RIED RA ETHIE ME TCO SO GE P250 pea ROEA AE E ISAT BT OSHRIE TT D ELAS P280
250. pH pH OECD 1 OPPTS 835 2110 OPPTS 835 2130 111 pH I 5 4 7 9 3 2 3 2 3 3 2 4 1 OPPTS83
251. 2S LH j 1 f ON NPD
252. BCF 3 Ape ray an A9 5 2 3 3 F A9 5 2 3 2 OECD OECD 305 1996 CHS BCF Kow A9 5 2 3 4 a RITE GLP DRAR TEDN A A9 5 2 3 5 DD A OUR OECD 30 1
253. 3 1 1 2 BE BETS 3 8 1 2 3 9 1 2 1A 1B 1C CAPS KE ERALA Bae bees es PSA hOMEDRBET ED BLALWGE P261 3 1 3 4 3 4 1 1A 1B 3 4 1 1A 1B 3 P260 BIC ER AHS 3 8 ANZ ILAE 3 8 3 ENALHURL THE P262 3 1 12 P263 PS 7 P264 3 1 1 2 3 4 ic a MSE be
254. 447 448 7 GHS 449 450 7 GHS GHS 1 2 GHS OO QOL 2 CQ UNXXXX 2 1 4 10 5 2 d BFR 1 4 10 5 2 a O 1 4 10 5 2 b 1 4 10 5 2 c 1 4 10 5 2 e LEP AEE AETERNA EJL OA BLE EER OWE YT SRE EPMA ZED BIKAWIKOMRAL MERR SHORTS GHS KERRIER CHATS LERTE S 451 2 1 2 GHS
255. Et eg E NT oH FARR CIR Koc fli a7 7 7 VI7K aS AUREL Kow 25 Fill CES FP E AFA BYDAOS 2BAF CE SEGAL A4 3 18 13 A4 3 13 1 ETE A4 3 18 1 1 tH ime lz EITI Eg SDS 8 ffi T S MMII L ORE A4 3 13 1 2 A4 3 13 1 3 A4 3 13 1 4 A4 3 13 1 5 BES ATA W Z ail iN ASAN E 1 Vq Li JA K E A4 3 12 6
256. ee ee RAE AQT 5 3 lt AO ABIS A8123 mo ae BITS 4 1 4 E E L ID E
257. 1A 1C H314 P260 P301 P330 P331 P405 P501 PEAY PICEA SH I BIEL Y PSR ORF AS BATE DE LIA BE P264 P280 P303 P361 P353 P363 Es P304 P340
258. Bibl 1 ADI AEI 1 1 A5 2 2 8 3 A5 2 2 9
259. EFEM E A9 3 5 6 2 a b c d A9 3 5 7 A9 3 5 7 1 HERM ee EUT ue 1 FE rere ig HOWE lt BRU COU Et E
260. P251 346 2 4 B HEOK 1 H270 P220 P370 P376 P403 P244 947 2 5 B wee H280 H280 ee H280 P410 P403
261. 2 A9 3 5 7 2 Os BLOBGWO KAT Baw ome E ASH BRE OWED
262. ETER D XIZ GF BMG ETIA AJTE SIV TU 1 FAT B HARADI RIT SMEG ETARA RARE 181 8 3 2 BH 5 2 1 3 2011 1 1 255 1 PEERY D R IZ BT BE ETILA fi He Fa SRE a HI 6 8 A 256 REO 1 2 3 4 5 Gs Gs
263. 2 15 B C H242 D H242 BATE H242 F H242 P210 P411 P235 P501 BUKERE EO b O OL I ARAM DIR C P220 P410 P420 P234 P280
264. E Z Bar BPTLLeBATS COFIIRDSE 2 a 444
265. FE QSAR Biodegradation Probability Program 1 v A9 7 A9 5 1 3 M RAH V 9 TV 9
266. 2 loome 0 OC HX EHD lt E A FIZ I fetal ee gs ei A9 4 3 3 28 BE DR A9 4 3 3 1 aie f MITI 1992 28 ie GE m
267. 4 80ppm 6 15 0 12 TR 0 48 mg l 21 41 amp 4 80ppm 6 18 0 12 0 24 0 48 mg l A8 5 1 Patty F Ed 1994 Industrial Hygiene and Toxicology 4th Ed pxxxx xx New York Wiley Interscience 2 Smyth H F Carpenter C P Weil C S and Pozzani U S 1954 Range finding toxicity data Arch Ind Hyg Occup Med 3 Fasey Headrick Silk and Sundquist 1987 Acute 9 day and 13 week vapour inhalation studies on Globalene Hazexyl Systemol Fundamental and Applied Toxicology 4 Wyeth Gregor Pratt and Obadia 1989 Evaluation of the developmental toxicity of Globalene Hazexyl Systemol in Fischer 344 rats and New Zealand White rabbits Fundamental and Applied Toxicology 5 Ete 466 9 468 9
268. N ee eure tee TOS E E eae P Hh JEEE e a J A PNAS BO AiO ica orn CAs nen bea nee 7 SDS SDS 437 K A6 1
269. TE 485 c L Cso LE Cs d mgA
270. ope nia H j HCAS 1 2 MEE j
271. ral a AG6 3 5 1 2 436 A6 1
272. E QSAR 3 1 5 Niemel 2000 A9 4 2 4 14 2 H E QSAR Syracuse Research Corporation QSAR 1 HYDROWIN 1 67 E EU QSAR
273. RID ADR 2 3 4 ATA
274. 1 5 1 5 1 SDS D9 y KATMER DRET r CA 3 2 SDS GHS SDS SDS GHS A4 2 2 ARHIFS amp
275. 5 5 HH 6 8 5 MM E f myg BET Ns g h G SDS A10 5 A10 5 1 ABBA LHE A10 5 1 1 KICRT AAS LOREAL PROFILES b OCHS a A10 5 1 2 b SO6341 A10 5 1 3 c A10 5 1 4 d PEPR
276. pH yy O MARHE LAEN TOSHA TILA LH 2 11 5 OFF in vitro a b as 7 4 3 2 1 2 ERYOF 2 BAF CELLU EGS ORE OR 3 2 3 2 3 DLE ORRY A ENEO GE H 5 1 3 2 3 3 4 1 ER DRET 2 ODS BADHA
277. 2 GLP ISO o pe A A E ASTM E GLP EDEA A 3H PHJ e CE t Pedersen NN a a A9 3 6 2 4 o E
278. DNM A 3 2 COMODEBAZORPTE 3 2 1 1000 3 2 2 TL gt fet BAE ly
279. E EDTA EDTA A9 3 3 5 QSAR OH QSAR A9 6 QSAR 1
280. 2 0 1 3 7 3 3 BLO 3 7 1 3 b 3 0 3 7 3 3 3 7 1 4 A2 24 b 3 7 tees 1 BAP L URAT Z OD SHAD 3 7 2 NE eee 2 BRWOF 2 BAF CELV GA ORE PP ZL 3 DLE OF WPA EH LY BP seen ee 1 ld arr 2 a 0 1 3 7 3 3 3 7 1 1 AR b 0 3 3 7 3 3 3 7 1 2 289 A2 25
281. A9 4 3 5 4 Cs SE Ley E A Be E FJ EDE IE ID I rar ILS SM CVV ERED BK E LS BSAC Zev GED kk
282. es ATEI RIX EFI OAR P 200 Z LIEB O CWS ERI R Y UF ERRIN CV SEBANALAYRL TBR BO TDPRI Bi EP LIANG EATER UDGEE BE LV BMNENRS 5 348 2 5 ee PEEL HZ apg H281 AWLI R WEIR HOBeN ESE P282 P336 P403 P315 949 2 6 K 1 H224 2 H225 3 H226 P210 P303 P361 P353 P403 P235 P501 BU ATEEAIEIELO DDOL I RBA POR P233
283. ps 1 A BLORE Z Ob BWA 3 7 2 a b d _ 2 LEYQOF 2 BAF CERLUGE 2 1 ee 1A 3 7 3 2 1B 3 DLE ORM OBA INRE A JEG 1 NN 1 oo 1 b 0 3 3 7 3 3 3 7 1 2 1 BARLOMHRT 2OLDSEE 3 7 2 4 ERI iP 2 ERWIESHT SEELT 2BRLWG 8 7 3 2 2 8 DRE ORM ENLVGE Bett 2
284. Eg BCF I 6 1996 A9 5 2 3 6 BCF oS ABC HER L TA Ffi Kow BCF if A9 5 2 3 7 log K 6 log Kow 499 Al RE EYE DS iit BREF El 3
285. Rekker amp De Kort n 1054 r2 0 99 1979 n 20 r2 0 917 sd 0 53 me 0 40 Niemi 1992 MCI n 2039 r2 0 77 n 2039 r2 0 49 Klopman 1994 98 n 1663 r2 0 928 sd 0 3817 Suzuki amp Kudo 424 n 1686 me 0 35 1990 n 221 me 0 49 Ghose 1988 110 n 830 r2 0 93 sd 0 47 ATOMLOGP n 125 r2 0 87 sd 0 52 Bodor amp Huang n 302 r2 0 96 sd 0 31 me 0 24 1992 n 128 sd 0 38 Broto 5 1984 110 n 1868 me 0 4 ProLogP 533 534 sun 9 IV 1
286. 348 HI EV E A9 4 3 5 5 0 RR OECD 301D 1 DOC OECD 301A OEC
287. a t SDS 8 b c A4 8 6 1 2 KAFR AX LT PVC A4 3 6 2 RELOPFLBAE A4 3 6 3 EfUADERMOAFOT ER LVR A4 3 6 3 1 a 2 b A4 3 6 3 2 a b
288. 556 lL 209 E Ay 3 10 15ml TS A10 5 1 9 3 A10 5 1 10 HNOs1 2 pH 1 A10 5 2 3 4 A10 5 2 3 5 a MRT OED DA FORDS 5
289. Ly ay Si 1H GSLMs OECD 1 9 A9 7 AZAR OECD EU 5 11 A10 1 2
290. WAF 2 L E Cso 1mg l Img ao E 484 A9 3 5 6 BARELY A9 3 5 6 1
291. PEJA TULA ZNB VP DK h ORTF KAT EDD LNMAV GE P263 P264 2 P270 392 HEE lt E 3 8 B 1 H370 lt lt gt gt lt gt lt gt ICI BL DPAPULI R COPEE ZS S Wha EAS S lt lt gt gt CI MORD ODIS BEDA ETEO ED AEII AEA SHWSBGE HECE E METS P260 P308 P311 P405 P501 UAE AIS ARRAS E eRMALE 18l REEF ERORAS DARA
292. YE 4 1 3 5 2 4 1 3 5 5 3 3 1 x M x 100 2 x 10 3 gt 25 4 BRERDO IG 1 ERE EIO CHIN TREO ZV VED IOGE AFT AREA COL K x 294 A2 28 b 4 1 1 REET SYAOGE a NOEC lt 0 01 mg l b L E Cso lt 1 mg l BCF 500 log Kow 4 aia 2 EPHEL PEDRA a NOEC lt 0 1 mgl b L E Cs0 lt 1 mg l 3 BRYOF 2 BAF T R GE ORE DRAN 4 1 3 4 4 OR ORRIA SNAG NP CHAUTIBPE 1 1 x M Z 25 HERS M 4
293. BEERDA BIT SAE EF HATIR E SIV TVR 6 2 6 1 2 3 4 5 gt gt O ee ERDIZ AT SAE EF 6 2 FR A TF 6 1 2 3 4 5 SO SO SO eee TELE RO OGEZGF SME EF RJT IJ
294. 1 10 40C 20 5mm2s 1 YARBLURART 4 Ob BADRA 1 40 14 mmz2s 2 BAYOR 2BAFCELV GE 3 10 3 2 3 DLE ORFMABAASNAVGE RORA 2 a 2 10 40C 14mm2s az pe b 2 10 40C 14mm2 s
295. 1 10mgC l E oO TA ee E 749
296. 2 H221 P210 P377 P403 PUKEKO DOOL IREK HOR P381 Eo 343 2 2 EMIS PRL A TEMES LTE Gf kL H230 B TEMES LTE RR inf L H231 P202 AD ORIZ EFHWEPRRIELA AIC BIET SERGE DARL TS BUSEIL DS 3 ERE MOU TIZI AKT A DEAN CN ORE
297. KEE BIER GRIEF 8 EAE EHEIE P312 P260 BF CALE HH Af EBNALAHUER LT P271 s LEDGE P405 395 REIL lt Be 3 9 1 H372 lt lt gt gt lt gt lt gt ICI BL DPAPULI COREE ZS S Wha EFAS S lt lt gt gt ZI MORD DIES BEDRA ETRO 2 EBR EHC AE SHWSEGER HECE ERREI O P260 P314 P501 BU ANBIN AIS Z KREUAT V EBA Liz
298. 5 A2 10 2 10 mes pm s 5 25 mm 140 a 100mm 140 C 25mm 140 C CHEN HE 8m3 100mm 140 C 25mm 140C 100mm POT 120C TE 450
299. A6 3 7 AE FRACTAL TIL FHL 1 3 A6 3 8 BWG ORRWE PH ILHIAICEIT ZAF NIR A6 4 A6 4 1 XREN AG6 4 1 1 A6 2
300. ERED CWA A9 2 2 BHEABLU 2 cone EZS 1 GREHE E Ak AE eA A9 2 3 p A9 2 3 1 AAI AF AIS 4 f A9 2 3 2 tek H fE FEE NAN
301. mh 1999 1 Pederson 5 1995 Langenberg 5 1996 US EPA 1993 L ae NAD VEE IL OD log Ks E E QSAR
302. pH 7 6 8 5 pH 28 5 5 8 5 ECO pH A10 2 3 2 A10 5 1 7 pH8 1 COs pH 0 2pH 10 7 pH7 6 pH8 8 5 pH CO pH K A10 1 2 EFFI AWE TSE BERET h 2LOPER BAER L ORIEL LINCS DEEZ ON RM FZ EHRANSE LPL T I ORGBLELAWIEDF EGANL FET LREGAROKHBYKE ILE OECD202 208 D2 XV AR VEADI REMERA B EBEBAR EBSD LNB BIKIBI S CaCl 2H2
303. rts Pol oH b A9 7 2 A9 7 2 1 KEZET Z ODORI CO TI OR taney ee aay A9 3 A9 7 2 1 2 A9 7 2 1 2 1 Zeke Had v LE Cs lt
304. 2 15 K a B H241 lt gt R CEA P210 P411 P235 P501 KIERRE EO b O DL I LAK Di C P220 P410 P420 P234 P280 366
305. 3 LFER LFER log E BCF E TORD ARD ny an dg H log Kow LFER FE UV
306. 3 8 3 P313 3 2 2 3 3 3 BE 2A 2B 3 4 1 1A 1B 3 5 1A 1B 2 3 6 1A 1B 2 3 7 1A 1B 2 3 7 P314 3 9 12 P315 2 5 320 1 2 3 4 5 P320 3 1 1 2 KE OM BN OR FRL ELA P321
307. ONLINE US National Technical Information System EPA FIFRA 1982 The Federal Insecticide Fungicide and Rodenticide Act Pesticide Assessment Guidelines subdivision N chemistry Environmental fate and subdivision E J amp L Hazard Evaluation Office of Pesticide Programs US Environmental Protection Agency Washington D C 1982 ONLINE US National Technical Information System OECD Test Guideline 107 1995 OECD Guidelines for Testing of Chemicals Partition Coefficient n octanol water Shake Flask Method OECD Test Guideline 117 1989 OECD Guidelines for Testing of Chemicals Partition Coefficient n octanol water High Performance Liquid Chromatography HPLC Method OECD Test Guideline 305 1996 Bioconcentration Flow through Fish Test OECD Guidelines for Testing of Chemicals OECD Test Guideline 305 A E 1981 Bioaccumulation OECD Guidelines for Testing of Chemicals OECD draft Test Guideline 1998 Partition Coefficient n Octanol Water Pow Slow stirring method for highly hydrophobic chemicals Draft proposal for an OECD Guidelines for Testing of Chemicals 3 LF OY bIE2000 429 AHEILO BS OCHY LUD FILL ORAM bSIVLEOREOMMIGEC TC EB PNW EHT E
308. S a He A9 1 4 Exe i EN E 4 a A9 1 5 9 BE E
309. 4 E 4 E pay are E PACE Dear AES 4 pH SKOR 1 E ZN E E
310. 1 eo AS 4 6 BAN BEMMEL Ate A8 4 7 ERRUA PYRE Ames ZBITA in vitro yo in vitro Ames 0 3 15 mg F IVC CHO 0 1 0 8 mg ml S9 0 08 0 4 mg ml 89
311. 4 UN EFNIL TERENE E ORIIRE L E EF NAME VD 5 IMDG Code 014 KAT ANZ FE RG 6 ADR EIL KI ENR FE OE RGOF KREISKNMN BE 7 RIDEIX KAT ANK P L DEROO RIC BIT BRAIRE 8 ADN EB KAT ARK WERKIE DEROO AXI BIT 3 GIN GHEE V9 9 MARPOL 73 78 I 1978 LOMA E BEZO DA D DRRR BIT B 1978 OHBEBL V9 10 IBC Code E 2 ERIE Fin OIF 5 FERRIED O OMA OPER RR BIT B ERIE V9 424 A4 3 1 1 IBC Code17 18 IMO MEPC 2 Circular A4 3 15 15 SDS 3 A4 8 15 1 KB4RUNCBALZE RPL ORI RH T OH
312. SPARC log Koy gt 5 SPARC KOWWIN SPARC QSAR CLOGP KOWWIN CLOGP AUTOLOGP log Kow SPARC a Niemel log Koy M E HE EHRT 5 EAM RTT log Kow OAR OL 9 7 log Kwl oT FOP APAABIEMIC PWS 3 E Bila Le n 501 r 0 967 TemaNord 1995 581 b log Kow MEMEZ FRM LU CPB Ty hL 18058 BAIC CRA LE ES 4 Syracuse Research Corporation 1999 LOGKOW i log Kow 4 25 8 DHANI amp BLE GWUZ OV CHE CHS EFM SAT Do A9 5 3 BOF BEO Kow ICRI Ul TRIIR RO B
313. 1A penis error 2 BAWOF K BAF CERVBA orani 8 4 3 2 BLA ee gt j OSAD 5 ore omenmM sini EA Ranhota RARE TeX Pek 1A eo bee 1 MEROUREF F Ob 2 BOWOD 1B ngs a e 2 MIO ABAF CELI OHA REDRA 3 4 3 2 Ais NOES 5 ORE ORUE 1B 2 iyi sh 1 0
314. 3 2 1A 1B 1C 3 2 2 3 3 2A 2B 3 7 RERA tE HENE R 38 8 1 2 RERA tE KIE R 3 9 1 315 1 2 3 4 5 P270 3 1 1 2 3 4 3 1 1 2 3 7 3 8 1 2 3 9 1 P271 8 1 1 2 3 4 REE AY ised tE HENE E 3 3 8 3 3 8 P272 3 4 1 1A 1B P27
315. UL 524 QSAR US EPA EC 9 II 1 1 1 OECD 1 2 OECD OECD 1995 1 3
316. 4 E LIZ LIL AO faze E 4 1 fF OEE Comotto 1979 Wakabayashi 1987 Goodrich 1991 Toshima 1992 ADHERE LZ F FAC 500 Sa BCF Oks
317. EE Ronix BIT SG e ENAUT IRRE SUCRE 1 1A 1B FREER OD tpt BIT 3G e ETNICII E SITE 260 1A 1B 2 WOBK 5 OER D fH DIER D D D ILS BEHET IES BBHE CH IES BBHECE WOEBREME WIEBREKIZ BHA ASNWSH CHANT SG CHANTSF E BECIE BE e A ECIS BE A A EIES BE Be me Be me Be me EEE RODRMEIZIT SME ETNA IRE SVT 1A 1B 2 A DIER D gt D D IES BBA CL WE EBREHIUE MAAR WSF BO BERIE BE BBE ahh fl DIED D D IES BRA ETE WO E BRIERE MASH TOD E AERIS BE LEE whe 2 fl DIERE D gt 5 D IS BBA CL Wo E BRIERE MAAR WSF BN B ERIE BE LES whe ETERO MAIBRIT BE ET ARAL CITE S NUTI 261
318. t CLOGP US EPA 1999 LOGKOW US EPA SPARC US EPA 2000b SPARC 1 CLOGP E SPARC log Kow 3 K E Et log Kow la BUY Lipnick 1986 A9 6 4 10 AME BCF A9 6 4 10 1 BCF fi Vv rh E tx BLE Ht Kowz6
319. 417 EK MEZ P H b c A e f kid SDS 7 A4 3 8 3 AA ARBK PPE 2 EDA REHE I 1 A4 3 8 3 2 a b c d A4 3 8 3 3 FH
320. ASTM E 1022 94 OECD 305 996 OECD 305A E 1981 ORCD 305 1996 1022 94 log K z gt 3 1 2 2 OECD 305 ASTM HH a b c d e f 1 2 3 GMO BETOZ 2 ane rae CID YE A iBT M H HH BCF see TZ Kow o 1982 E E gt ae r
321. CREAMED A EIT ORRET D VETERI P362 P364 388 3 5 1 H340 lt gt 2 H341 lt gt lt gt MOKA OIF S BORE CLAW E BRAE MAAR CWSBHA HELE EAMETS P201 P308 P313 P405 P501 P202 P280 389
322. Date P201 P372 P401 P501 P202 P280 ym S P373 P380 338 2 1 11 H201 LZ 3 1 2 H202 a 1 3 H203 P210 P370
323. SDS SDS T A4 2 2 2 SDS 8SDS Sy 409 A4 2 2 3 SDS
324. 200 210 220 230 lt A A3 1 2 2 A3 1 1 A3 1 2 A3 1 8 1 2 MOBS DIE BRA ETE WO E DAEB EA AN TOSHA AFCE ERAT S CLARO LPU IT N COPBE ZT SWHEEAITS uy 3 GHS 4 301 A3 1 2 3
325. 3 6 PEL Sle eS A ciate See ie Rone ean nd
326. 3 2 1A 1B 1C 3 8 1 3 3 2A 2B P352 8 1 1 2 3 4 3 2 2 3 4 1 1A 1B 322 1 2 3 4 5 P353 2 6 H 1 2 3 3 2 1A 1B 1C P360 2 13 1 5 6 2 14 1 P361 2 6 H 1 2 3 3 1 1 2 3 3 2 1A 1B 1C P362 3 1
327. 1 3 1 1 1 2 1 8 247 1 2 A B A IIMB BEER D XIE TOE ETILA amp AEE FL BIA Ct ay 1 2 8 EERO HA IZ ey ee amp AIZBSE YU
328. 10 SY BEE DS eS OECD 301 10 H AEA HAY C7RV Ay RET ORCD 301D 10 E MTITT 1 OECD 301C 10 H 10 10
329. E 10 301C 25 104 108 520 ii 28 7mL MTTTI OECD g se 3 2 3 OECD 3 2 4 BODs 5 3 2 5 1 gt 709 3 8 AEMEDREE 3 3 1 1 of X kU ASTME 1625 94
330. E BCF BCF 4 1og K 4 4 og K H QSAR log K A9 5 4 8 BROAD BCF log
331. RR pages A9 2 6 F Z ORE A9 2 6 1 GLP i ne OA een
332. b gt o A9 1 10 OECD a 4 E
333. 2 3 SDS SDS SDS no N pe JN Se Whee 2X 5
334. 2 H272 8 H272 P210 P370 P378 P501 P220 KRY XPD EWKESUHBBE P221 Bye P280 362 2 14 B HEOK 1 H271
335. 3 8 1 2 T ERRETIRA EDF BAF CELUGE OREO TEM 3 8 3 3 OLE OFM AGA ARGU GES DED AE GEA WILK 2 a 196 10 3 8 3 4 3 8 2 3 b G 1 3 8 3 4 3 8 2 EF Gi 10 3 8 3 4 3 8 2 3 a
336. GHS x X GHS ORK 1 GHS v 5 10 A6 5 13 DAF 2 EE ise
337. 3 1 3 H331 P261 P304 P340 P403 P233 P501 ROERNE CEKER ESED IEEE HEDHA P311 P271 P405 Es P321 FR FEO FEN LILE EL BILGE 378 3 1
338. E E Fz FA 506 log Kow A9 6 3 4 QSAR o 8
339. OECD Test Guideline 201 1984 Alga Growth Inhibition Test OECD Test Guideline 202 1984 Daphnia sp Acute Immobihsation Test and Reproduction Test OECD Test Guideline 203 1992 Fish Acute Toxicity Test OECD Test Guideline 204 1984 Fish Prolonged Toxicity Test 14 Day Study OECD Test Guideline 210 1992 Fish Early Life Stage Toxicity Test OECD Test Guideline 211 1998 Daphnia magna Reproduction Test OECD Test Guideline 212 1998 Fish Short term Toxicity Test on Embryo and Sac Fry Stages OECD Test Guideline 215 2000 Fish Juvenile Growth Test OECD Test Guideline 221 Lemna sp Growth inhibition test EC C 1 Acute Toxicity for Fish 1992 EC C 2 Acute Toxicity for Daphnia 1992 EC C 3 Algal Inhibition Test 1992 EC C 14 Fish Juvenile Growth Test 2001 EC C 15 Fish Short term Toxicity Test on Embryo and Sac Fry Stages 2001 EC C 20 Daphnia Magna Reproduction Test 2001 OPPTS Testing Guidelines for Environmental Effects 850 Series Public Drafts 850 1000 Special consideration for conducting aquatic laboratory studies 850 1000 Special consideration for conducting aquatic laboratory studies 850 1010 Aquatic invertebrate acute toxicity test freshwater daphnids 850 1010 Aquatic invertebrate acute toxicity test freshwater daphnids 850 1020 Gammarid acute toxicity test 850 1020 Gammarid acute toxicity test 850 1035 Mys
340. A4 2 4 SDS A4 2 4 1 SDS 1 5 3 3 s5 A4 2 4 2 4 3 SDS 1 SDS A4 2 4 8 SDS A4 2 4 4 A4 2 5 A4 2 5 1 SDS A4 8
341. A9 7 1 7 Ny APE EE 2 2o 28 H E Ate 2 511
342. 4 H332 e P261 P304 P340 DUANE AIS A RAT USRA RHE P260 BAM ER SH B BEII LT P271 Es P312 379 3 1 BL 5 H333 P304 P312 380 3 2
343. A9 5 2 4 2 K Kow HPLC OECD 107 1995 OECD pK pK pH 117 1989 EEC A 8 1992 EPA OTS 1982 EPA FIFRA 1982 ASTM 1993 pH OECD log Koyw 2 4 n H
344. A9 3 A9 4 A9 5 A9 2 3 6 1mg l BCF500 BCF log Kow 24 4 E A9 2 8 7
345. AER CHO f ROE DAUR SCE CHO f goes A8 4 8 ASE A8 4 9 ARTE f v Bess 465 E 3 lt BE BA 21 41 amp
346. CO EMAL elas 304 AMICON EN SSN 2 MCL 162 MITI I 41 25 142 ee MTITI I 138 97 523 3 8 3 EU 115
347. E IOMC ZL SHRMNMS AFA GHS OFA SH SAH ZORE IFCSASG3 98 32B 429 A5 2 A5 2 1 GHS 1 S El ADY AA f D a b c A5 2 2 A5 2 2 1 A5 2 2 2 GHS Bo lt Be iF i Nia BRA
348. 1og Kov DHE TOR a M 1 log Kow Howard Meylan 1997 CLOGP Hansch amp Leo 1979 CLOGP Daylight 1995 n 8942 r2 0 917 sd 0 482 n 501 r2 0 967 n 7221 r2 0 89 sd 0 58 LOGKOW KOWWIN Meylan amp Howard 140 260 n 2430 r2 0 981 sd 0 219 me 0 161 n 8855 r2 0 95 sd 0 427 me 0 327 1995 SRC AUTOLOGP Rekker amp n 800 r2 0 96 sd 0 387 Devillers 1995 Manhold 1992 66 SPARC log K EPA
349. 4 1 aL 3 VEE Mla a L H412 4 TEE lage L H413 P273 P501 LEEZNE LIE 402 4 2 1 Wk Ae H420 J P502 403 404 3 4 A3 4 1 1992 6 24 92 58 EEC SABS 0265 1999 405 406 4 SDS 408 A4 1 FRX
350. 8 OREORE SI Leb BE a 0 1 0 1 1A E 1B 1 HAR ORAT Z Ob BEADRA a 1 0 EERO FTF 2BAFCERV EGE DRXOR J A 3 4 3 2 DLEOPG MOA RLV GE HABE OD TS HI 1B b 0 2 E IDES my
351. LEC OF E EDTA E 1H NOEC E 4
352. SDS ON NN 410 Ae SDS SDS SDS SDS wa vB EDERA EM SDS EZR LT AG 1 5 3 2 1 E 1 3
353. lt gt lt lt gt gt lt NE LAINSEBONARELERT Z lt lt gt gt Clk MORD DIES BEDRA FTO EBRENW SALAS PCW SAE ELIE EG MTS P201 P308 P313 P405 P501 P202 P280 os 991 3 7 B GEM TEE ERB L H362 P201 P308 P313 P260
354. 1 A4 3 4 1 LERRAREZ OR A4 3 4 1 1 E FI Yun A4 3 4 1 2 a b c d A4 3 4 2 E gt sa EY 9BBIS E PPE Ke BEE E FEO TEKS LS i
355. c A4 3 7 1 2 a b c A4 8 7 2 MERHAT ZAETRBRIE SDS 9 a G GD Gi Gv v vi b i ii iii iv 416 v vi
356. 2 A9 6 4 183 ABLUS V aI IIT BREME log Kov ay Oo
357. 3 10 B 1 H304 2 H305 P301 P310 P405 P501 P331 398 4 1 1 H400 P273 P391 P501 LEEZMELIIUE 399
358. REKTAL REKTAL TE teL TEE eL TEE eL TEER OOM EIZCST SAE EPIL HAJT IJAE ENTRO ETERA DHX CET SBME EF JRA CVE 1 2 FABRA CA IN EFIA F A 9 3077 3082 9 265 face Ba FREER OD tic GF SG e ETNICII SITY 266 2 268 2 PESER OWE TS HE MBBL OM ER OOO 1 Ye o EE RO WE MIT S Me RABE OM ERE OOO 1
359. TALE ONO BUS SEF OATH IF H THH log Kow 8 3 FF Kow gt 9 log Kw FAN E A9 6 4 9 2 E pKa HED AV log Kow 6 6 5
360. 1 BILE o4 E lt FHI 20 A9 4 8 2 BAO A9 4 3 2 1 A9 4 3 2 2 HA
361. pe ty FEE ea ES LOSER A4 3 4 3 LBV CEPR R E BRE NDRIT A4 3 5 5 i A4 3 5 1 IKA ESO A4 3 5 2 MED DE C BEDERE
362. 1 E QSAR Jey he BETS h QSAR A9 6 4 9 nn KEG Kow A9 6 4 9 1 2000a LOGKOW log Kow K Hi log Kov Z Rri A9 6 4 9 3 log Kow E
363. 1 SDS A4 8 11 2 REN ea eR Oe S GHS 420 A4 3 11 3 SDS A4 3 11 4
364. H 2 8 A B C D E F 2 15 A B C D E F 2 16 1 313 1 2 3 4 5 P235 2 6 1 2 3 4 2 8 A B C D E F 2 11 1 2 2 15 A B C D E F P240 2 1 SBE OER ESCM Ca 1 1 1 2 1 3 1 4 1 5 EA 2 6 1 2 3 PEKEN BUR LDA amp IBA LETHE DERA EL UBE IEA AWSIE LTE CHEBGE 2 7 1 2 PP EKEN BUR LD EBA LET AE P241 2 6 1 2 3 2 7 1 2
365. LE C a LEC 1 1 np b PAHRICKU CARES TEED LDCs 2 2 c L E Cso 3
366. 1 Nt a 1 0 3 9 3 4 3 9 3 1 b 10 3 9 3 4 3 9 3 2 DAIL ORRAT 2 Ob SEE 3 9 2 Cte emg 3 9 2 EA tp 6 GE J E oe A OLE OAH SAUL fede oe a EORR DOIR EDSA E 1 1 10 Gabi D
367. BCF Crish Cwater D HEE L 1 2 4 BCF 1 2 5 log Ko 6 amp A H Ae HH 4 H 4 H log Kow log Kow 6 4 BCF FA AE LT Y E E
368. ce a 1 8 9 3 4 3 9 3 4 F E Gi 10 3 9 3 4 3 9 3 5 291 A2 27 3 10 pala 1 a b 40 C CHE 20 5 mm2s 2 BARBOR 2BAFCERLV GE 3 10 3 2 3 OR EORR HENRO RORA 1 a 1 10 40C F 20 5mm27s
369. pH pH4 7 9 Ht 10 E 3 pH 50 E E 5 2130 OECD 111 OPPTS 835 2110 2 4 JEZME OECD OECD 1997
370. 2 1 CEER 7 a a 1 4 H204 ZOE P210 P370 P380 P401 P501 AKERE DDOL IRAK POR P372 P240 RIED R ETHIE MEE TO GE P250 7 9 HREBLOC OMY 5 REKLAMA DBE P373 P374 BUT ASHES 5 kla P280
371. 7 b 2 BAYOT Z2 BAF CEL GA O7RE ORE 8 4 3 2 8 OR EORR IAH ZNR BEDEN IR a G 0 1 3 4 5 H i 1 0 b BA Gi 0 1 3 4 5 4 Gi 0 2 1A b 1 JAR ORAT 2 Ob B BADRA EEQOF 2 BAF CER GA D722 X ORE 3 4 3 2
372. 9 1 US EPA EC OECD 1994 Biodegradation Probability Program NN 3 8 4 EU TGD EC 1996 EC 1996 3 8 5 Biodegradation Probability Program VW QSAR QSAR YC QSAR Biodegradation Probability Program
373. Em Efe 4 A10 1 3 a b oS BRAM A10 2 A10 2 1 E a 9 A9 7 E gt
374. RN EC NR A92 NE A9 2 1 A9 2 2 A9 2 3 A9 2 4 A9 2 5 A9 2 6 A93 Ie Pet a g taken chet spabaeiatlec hain acon salience a E a EN A9 3 1 A9 3 2 A9 3 3 A9 3 4 A9 3 5 A9 3 6 20820800 2000022 Re A9 4 2 A9 4 3 A9 4 1 FR 4 A9 4 4 Ea L T i E E EE E E E A E EA A9 5 1 FE A9 5 2 A9 5 3 BCF K A9 5 4 A9 5 5 POG QSAR OH aan a a a e a GG sa bende Tuas Mea e A9 6 1 A9 6 2 A9 6 3 QSAR A9 6 4 QSAR A9 7 KA A9 7 1 FE A9 7 2 A9 7 3
375. 2 11 1 H252 2 11 2 H260 2 12 1 H261 2 12 2 3 H270 2 4 1 H271 2 13 1 2 14 H272 2 13 2 3 2 14 H280 2 5 H281 2 5 H290 2 16 1 303
376. ECOSAR US EPA 2000b SAR A9 6 4 7 ei ABR eM i SAR Pederson 1995 E QSAR E SAR 5 2 8 log Kow
377. 2 A3 2 3 5 5 A3 2 3 6 5 SA P241 aoa SUL ik WRAAA CL IBCAZRBEET SGA OAWAENS Sec A8 2 3 7 5 P284
378. 286 A2 22 3 5 E me T 1 EAB L URET 2 O b 5E 3 5 2 a b a ai 1 1A 2 BEA DF ZBAFTI LOA 1B 3 5 8 2 3 OR EORAIP AH ENR RE 1 0 1 1 1 WHRLUHBRS YLODDSEHOY 3 5 2 y Cs Maes ike A 2 RMGOF
379. A10 5 1 2 ACI 1 2 1 27 pH8 17 2 81 553 A10 5 1 8 1SO6341 2 O 2um pH8 NaHCOs 65 7mg 1 KCl 5 75mg l CaCls 2HsO 294mg71 MgS
380. FL Hansch E f E Lipnick 1989b 505 A9 6 2 ABHEOMNHFMLE TERE LORE A9 6 2 1 ade TEM E AR TT og Kow amp log C D QSAR Hipnick 1995 A9 6 2 2 4 E JE FY RB etm kere 3 E COLD RM QSA
381. NOEC POR HE H BDO ae LA B S cak ET NOEC E
382. 0 2 TROTE H E 50 E Be EDS 1ppm mg l 10 100ppm 10 100mg 1 100ppm 100mg l E lt A L CBORHI Cab BRIE Cw 50 ROU OS Lee aes EME 1 RT TA A dg oh ae RE EZ Las H 39 1 HEE k A E EEN EHE EPER E tA
383. A8 4 2 AGRI BRIE sane EE 7 6 3 alae 7 1 pA f EHDOR
384. AICHE D EGO WETS YG PRI L WERE 1 2 1 Sy N EERO WE TS 1 8 WE RRT L OAE 1 ate DE MIE LOWELM 14 EREE RD WET S DE PRBE OHEA 15 1 EUR lt LE BROWNE 2 Me RPL RA EL LG EOE A AICHE 9 o TRA FHERR L A2 2 2 2 sill 101 3 kPa 20
385. P372 P373 ka E S E 341 2 2 1 H220 P210 P377 P403 UKIERA EO DO ODL IS AEA POR P381 842 2 2 B
386. 14 E FAR RRA hea dg f TEE EHET 2 IL IEF COMPRIS ETZ b leh BULLEN TAF LES 4 D E o gt EDDY PARR FMA OHH b CLUE ERESZ NT Zev OECD EFA 210 GAO E EIER 202 Part2 FE EH 211 2 D aADEGAE BELO 201 RAER ME MD ESHER ERE Sf Cg OECD OECD 2006 A9 3 2 3 A9 3 2 4 ezti H FA 4 3 A9 3 2 5 A9 3 2 5 1 H BB CIR E DOH BEKO
387. P264 P270 396 3 9 2 H373 lt lt gt gt lt gt lt gt ICI BL DAPULI R COPEE ZS EMER EAS S lt lt gt gt CI MOKED ODIS BBE CAV EDEP AEA SHWSEGER HECKE ERREI O P260 P314 P501 397
388. PH 4 1 H Ay FE X E E pH MI 4 3 E 4 E Aas ekg Clie NN 0 s OP hh TAP E T
389. lt 6 LINITE EZI SETORA ERRET B MDE D DIES B BHECRW EBRE PICEA AN CWSHE H EIES BES i LHMMTHEEBEZITS BCOBBE LAT B fh DIERE D gt O DIES EAS BECRHWS EBREMIZ HHANTWSER FE RITS BEL eh EERO ORES SAE ETNII EENT 263 Pay TESTER ORE BIT BE ETNIE SATIR 264 2 3 TERA L WERE LL te Melia L te Belin L ELRETERO OWA GT SMG EFI BEAL CVS BATE S UTVR EEIE D CIT SBME EF ARPA CVE 1 ETILA F A 9 3077 3082 EFIA F A 9 RHH 2 8 4 Bult
390. 1 1 1 2 1 3 1 4 1 5 P402 2 12 1 2 3 P403 2 2 1 2 2 4 1 2 5 2 6 H 1 2 3 4 2 8 A B C D E F 8 1 1 2 3 H PEBRA FRKE 3 ED ILHE Ch OHA 3 8 2 3 3 8 P404 2 12 1 2 3 329 1 2 3 4 5 P405 3 1 1 2 3 3 1 1 2 3
391. 2 H330 P260 P304 P340 P403 P233 P501 YT DBIGIRA GER EIEL SHUD IEEE CHEE P310 P271 P405 P284 P320 A OM BA OR GF BELELGE 377
392. 2 3 2 8 4 1 E A 2 8 2 3 4 1 TERR 2 3 2 3 4 1 ie i p 2 B 2 2017 BH A2 4 2 4
393. 434 6 A6 1 RN SDS BH BHRE Se A6 2 A6 2 1 4 a 1 2 11 A6 2 SDS
394. HL A10 5 1 5 ec 0 2um A10 5 1 7 0 3 20 C 23 COPA C 1 5 C cf g h 0 2pH pH G G k 5 LOGQ
395. ZI TT a HED E EE OECD 1E MITI 301F OECD 10mg l OECD 209
396. 0 SDS Eee ht ah c eae ae m z a SDS CN 29 CT eee i SDS SDS 9 AN SDS DORR SDS Toan PPE
397. 2 12 B K wy 3 H261 1 P231 P232 P370 P378 P402 P404 P501 P280 KDB AP BK SU BBS 360 2 13 B HEOK 1 H271 jo aE P210 P306 P360 P501
398. 802B E 302C MITI 1 1 E EUC 5 4 PHASE OECD 306 OECD 806 DOC R 4 1 H CFE 60 CO2 4 5i E FE B 73 EPEC E DDL 9 DAR E
399. 3 2 1A 1B 1C P353 P304 3 1 5 one sn 3 1 1 2 3 4 p340 3 2 1A 1B 1C 3 4 1 1A 1B 3 8 8 3 3 8 PR 3 2 1A 1B 1C pasl 3 3 1 P338 x 3 3 2A 2B pee 2 13 1 pago 2 14
400. 472 L E Cs ry b c a TE AI RIEK d 1 e E a
401. EESNS b lt c A10 5 3 FAROE Hl CHL CHA BAD FEES A10 5 8 1 ERZ V gt D RRS EESE EEMO A10 5 3 1 1 80 A10 5 3 1 2 24 Aah 1 HNOs TE MAR EBRBL OCCA A10 5 3 2 pH 100mg l L 3 A10 5 3 2 1 A10 5 3 1 1 A10 5 8 2 2 7 28 7 28 2 6
402. ke E gt AS EDMI 4 1 ERTI BCF OECD 305 1996 3 K 1og BCF log Kov Q
403. 1 E DoE 1996 ECETOC 1996 US EPA 1996 OECD OECD 2000 A9 8 5 2
404. 3 3 2 BAR BDF BAF CE LW BES 3 3 3 2 a Hpt FO HO ZAR PX DLE OLRM DA ENR GE 2A 1 E E TEIARS 1 1 3 oe Gi H 10x b iii SIERO KAY SQA 3 2 2 2A 10 1 NR 3 3 3 3 4 PE 283 A2 19 AZT SBE LAG RUBE GEWLE 8 8 FEE tex pain y 1 BARUHRT Y Ob BADE a
405. A4 3 2 2 2 A4 3 2 8 MRE LCABANRWCOMODERA Blt 412 A4 8 8 3 PER ER WECBD FF OAD Retin FEE OHAN ESE SHE WA ENBAR BIT 3 BROGAN
406. 3 50 2 6 ZL 4 H227 P210 P370 P378 P403 P235 P501 P280 Ym S KBY RD ELIGKE LEGGE 351 2 7 B K 1 2 alle ie 1 P210 P370 P378
407. EN A CN 5 Bt A3 3 1 3 A8 8 1 4 TIPCS Z129 1 A5 1 1 Fe AN a BA AR A3 3 1 5 A3 3 1 6 BREW bat FT v 7 ERG 2004 sail GHS o E UCSC 1
408. 21 ILO OECD GHS GHS GHS GHS GHS 2002 12
409. A9 3 3 2 SRU fE L AROR a L Fe 3 H jen a b c 10 ARS HETE EK Plate A a Img C amp HA ba 3 wid 9 K 6 0 01mg I 1 0mg l UK NOEC ECx 4 DC ee hee 0 1mg7I 1 0mg 1
410. 2 1 3 n Kow EU Kow J ya A gt E n ELD E QSAR 2 2 RIZTLS Kow BAED Z ODRA E 2 2 1 K HPLC 2 OECD 107 1995 OECD 117 1983 EEC A 8 1992 EPA OTS 1982 EPA FIFRA 1982 ASTM 1993 HPLC
411. A4 3 14 14 7 A4 3 14 1 AES 4 4 A4 3 14 2 reas t GHS A4 3 14 3 HpRPFOSERIEZ FXR
412. CN M NOs M E o E A9 7 1 2 2 4 A RUELE T NRK FS IE PED 1ER ME 510
413. Kow QSAR QSAR log lt QSAR K n Kow EEC A 8 1992 OECD 117 1989
414. a b 1 100z g l 3 4 3 3 4 4 3 5 97 STP OECD
415. 2 10 442 K A6 2 2 6 amp 10 9 1 30 508 BB niri o 50 1 100 50 be saso Tiera ho 8 ARDY ee re a 4 EHPA Hi 7 j a a EREARO RMD AR N IZMERE APIID E 5 PD DEERE ZA IBERA CO BME BEA BRETTI Z LEERT D A6 5 8
416. 3 4 B 1 1A 1B H317 e P261 P302 P352 P501 P260 BAM ER SH BBEIR LT P333 P313 P272 P280 P321 FR
417. 4 1 3 5 2 4 1 3 5 5 3 2 1 M x10 2 25 4 PLERDO IG 1 EEL EIO CAIN THER ERDHEN AF T SPREE AVY COAL K x 293 A2 28 a KEREAMA IE GFHWIR 41 EB FEE 1 YARBLUART Y ODDS SEI OB ES 10 mg l lt L E Cso lt 100 mg l ages L E Cso 3 96 LCso 48 ECsyLCs 72 96 ErCso 4 1 3 4 3 a EN a a 4 3 5 5 3 1 x M x 100 2 x 10 2 25 M 4 1 3 5 5 5 4 1 3 5 2 4 1 3 5 8 3 10 mg l lt L Cso lt 100 mg l a
418. A4 3 10 1 ACUTE A4 3 10 1 1 A4 8 10 1 2 A4 8 10 2 FMR EH
419. EAU SDS pees B 439 K A6 1 10 3 9
420. Sd w os k BAL PHO eee 10 os 0 scl eet 12 PIR E g 464 A8 4 5 2 3 114 444 mg kg I l mg kg I lt Seay NOEL 0 44 222 amp 444 6 11 H 9
421. Sh ee Se Coe ee A4 2 2 4 Do A4 2 3 SDS OFF x0 A4 2 3 1 SDS 16 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 xa A4 2 3 2 SDS
422. gt A9 7 4 A9 7 5 IV V VI BCF Kew 469 470 A9 1 FR A9 1 1 a b A9 1 2 y A9 1 3 B
423. log Kow gt 5 European Commission 1996 2 3 5 SPARC SPARC EPA SPAROC L RT SPARC QSAR KOWWIN LOGP log Kow EPA CAS SPARC log Kow 5 KOWWIN CLOGP SPARC 532 1 log K
424. an H KAZ b gt OCHS 2 10 SORE E
425. 1 E Ff E ERR A6 2 j E A 10 5 5 6 10
426. 367 2 16 1 H290 P234 P390 P406 368 3 1 B 1 H300 2 H300 P264 P301 P310 P405 P501
427. E E 4 BRIR EE Z TE 4 E 521 E MITI II OECD Zahn Wellens OECD 3 4 3 4 1 ISO DS14592 Nyholm Torang 1999 ASTM E 1279 89 95 OPPTS 835 3170 3 4 2
428. G Ij Gi 0 5 Gi W 1 Gv A9 5 A9 5 1 AD i REA OWEMA BY EOAIKN DA WEEN ARIA SE CLR DS OWN 3 Dn A ATOI E H n aca ate thal Sad al Pinna ute 4 Ake ya A9 5 1 2 f
429. SENI R 3 8 RAE DEBE ORAS Y Ob BUBB 3 8 20 Ee 3 8 1 1 B el ae aie MDOT PBA CEG MED EIN PE Ob nee eee 8 8 3 3 a ar E LRT OR OMOEA ENEO BA oe oe AN LAUTEORECALNABA R 1 O a 1 0 3 8 3 4 3 8 2 1 b 10 3 8 3 4 3 8 2 2 WARLOMRT 2Y ODS HAD 3 8 20 7
430. EE BOD EE BOD5 ThOD COD A9 4 2 4 COMBED b 5P H HEL A9 4 2 4 1 4 E 4 E 4 1 4 1 2 11 3 a b E 4 HAE
431. APCAEBIETF B PREEZ DERE P242 2 6 1 2 3 P243 2 6 1 2 3 P244 2 4 1 ka P250 2 1 1 1 1 2 1 3 1 4 1 5 P251 2 3 1 2 3 314 1 2 3 4 5 P260
432. CASED HR amp Efe H E E ya 3 lt Ei A WAFS gt B h Q ARR D FEH pH
433. COD 5 50 ThOD A O EAS fE M H BA E eek E 209 1 RU C 9 C 12 4 20
434. 6g cm3 509 8 m A10 5 1 9 25mm 0 2 u m PES O8um 5 WW 555 A10 5 2 LAR A10 5 2 1 d
435. L E Cso 1mg 1 Jo ai WE oe DDS CILEMATC DH el SHED Te al TA ae a 1 ee E
436. 1 1kg 20 1 ite pte ease 1 2 a ee 7 A2 18 2 13 pestis 1 1 1 1 gt E 50 1 1 E E ETE i 1 1
437. Avame ouan REL TWEE ERT RATE 1 b 52 CV oRE CS c A4 3 11 15 ZCOMOFR GHS A4 3 12 12 A4 8 12 1
438. ae ae EE 2 5 A2 5 GER a 50 50C _ oy 50 2 a EIER 50 65C WER 65C b AS A 272 TE RAE
439. P420 354 2 8 C H242 D H242 Pr BATE eee H242 AAT F H242 P210 P370 P378 P403 P235 P501 BUATEMRAIRILO DDOL I REKA DOR P220 P284 P280 ym S
440. MW ayMWis A9 3 5 9 2 teal Ni A9 3 5 10 AWE A9 3 5 10 1
441. 1 2 3 4 5 P410 2 11 1 2 fi 2 15 A B C D E F P411 0C 2 8 A B C D E F 2 15 A B C D E F P412 509C LL LOWE LIS lt BLAVWTE 2 3 1 2 3 P413 ake C 2 11 1 2 P420 2 8 A B C D E F 2 11 1 2 2 15 A B C D E F P422 2 9 1 o 2 10 1 vee 2 12 1 2 3 P404 lt 331
442. 3 2 3 H317 3 4 1 1A 1B H318 BR7TRORG 1 3 3 H319 2A 3 3 H320 2B 3 3 H330 8 1 1 2 H331 8 1 3 H332 8 1 4 H333 8 1 5 H334 3 4 1 1A 1B H335 3 fe 3 8 H336 3 Be 3 8 H340 MOK DIS BS 3 5 1A 1B A ETC EBREHUIZHY Sf TW3BGF A PER ERRET O H341 MORO OIF 3 5 2 BBA CLAWS EBREHN HAAR TU A PEE E RRT 3S H350 MOD
443. 3 6 1 H350 lt gt 2 H351 lt gt lt gt CIL MORO DIES BEH ETRO EBRENW ISHEB APR CW BHA ECEE RRT SO P201 P308 P313 P405 P501 P202 P280 390 3 7 1 H360 lt gt lt lt gt gt 2 H361
444. 526 3 1 2 WED 4 DE Monod 50 E OECD 1995 4 OECD 1995 3 1 3 10 gM Ks So RETHA E 103 105 m1 2
445. Le B H241 Sf R P210 P370 P378 P403 P235 P501 BVA TERAI REO DOOL F REAR P220 P284 P280 pi S KEY RP EIGRKE LC SEBGE P370 P380 P375 P411 C
446. Lipnick 1991a SR Meyer Overton n QSAR 1972 Pde A E au HRC gt 8s He Zs 3 By JERAT BFR 5 pi bd RA ahah ee Shins OAS FE
447. fib 2 2 1 4 9 I E JEA Schwarzenbach 5 1993 E E 2 2
448. pH 4 5 KEHOE 528 9 BCF K s 1 BCF 1 1 i 1 2 BOF DEBRI E SMEDE ODITE 1 2 1 4
449. 0 1 1 WARLOART Z ODSEAY 3 6 2 d EEQOF 2 BAF T R 3 6 3 2 i Ee NE lt A gt EZA 2 3 WREN RE MDR 2 2 a 0 1 8 6 3 3 3 6 1 1 b 1 0 3 6 3 3 3 6 1 2 ok OWIE o TZEXARORFKMNLT YE EIT OPW L So 288 A2 24 a 3 7
450. 1 2 E OPPTS 885 8110 ISO 9408 9439 10707 OPPTS gt 9 E OECD OECD 301A F
451. 1 10 100mgl A10 5 2 3 1mg l OU pH 5 5 6 pH 28 A10 5 1 9 6 pH 7 gt EL 1 HNO 24 3 10 100mg 28
452. 3 2 3 2 3 3 DLE OSM OA ETA GE a 3 Gi 2 1 10 Gi 3 10 Gi 10x 1 H 2 1 10 10x 1 2 8 10 b Annet 1 3 8 8 3 2 8 8 4 281 A2 19 3 3 1 CEE NAR DB BEDRA a b 21 4
453. BAE a rl pyr H E IEF E FU EET B 4 Et S o E 423 Fa A E RY BELA ese
454. He 2 E x 2 0 1mg 1 E E1 0 1mg l 1 0mg71 2 4 E 3B 9 Y TE E 2 BHS A EC D AM Ey H al
455. 3 1 1 2 3 3 2 1A 1B 1C 3 5 BE 1A 1B 2 3 6 1A 1B 2 3 7 1A 1B 2 RE REM ied ete MENE ge 3 8 1 2 FERIRA E HENE R KERV 3 3 8 3 3 8 3 10 1 2 P406 2 16 1 P407 2 11 12 P410 2 3 1 2 3 EERO EET AAA O A 2 5 SEIS P 200 2 L RTE BAD ALY eB HR ANT WSBBNIILHRL TARY EV DEP BAF TEBE IP ERASE AITO MOFBER ELV GAICIRS 330
456. A3 2 1 2 GHS 5 GHS 3 A3 2 1 3 A3 2 2 A3 2 2 1 a X IP precautionary Statement b 1 2 3 4 5 c A3 2 2 2
457. A9 5 5 5 a BCF O BCF2500 ZOYAITLEDMRMO THEIL BS Gi BCF lt 500 2ZOMAIVLEMRMO THEIL b BCF E gt log K Gi log Kw 24 ZOMAITLSEDRMO THEE BS Gi log Kw lt 4 COYAIMLEDIRMO THEIL c BCF log Kow log Kow i ii A9 6 QSAR OF A9 6 1 E A9 6 1 1 E FE E 1986 Meyer Lipnick 1989a 3A H A m CAU TWA RH A9 6 1 2
458. DOR P240 AEC BUR LIE ERE AL BT BE P241 EPUABERET E HIED b BHE P280 pi 9 BY ZF EKSE HA 352 2 8 r2 A H240 P210 P370 P378 P403 P235 P501 BVA TERA O SO ODL I REAR DDR P220
459. RE ZR AAR BCF 4 1 14 RHENT McKim Goeden 1982 FF f E Opperhuizen Schrap 1987
460. 4 2 25 4 BRERDO IG 1 ERE EIO CHAN TRETIRA Zl BR DRE KECE AREA COAL K x BF p J 296 A2 29 4 2 Ne 1 BADHA Oo 1 iik He 2 BEDRA 0 1 97 3 300 3 1 ffi A8 1 1 FRX A3 1 1 1
461. 7 29 WMHBLOCORB D6 AAT BE KEI OBE P373 2 1 1 1 1 2 1 3 1 4 1 5 P374 2 1 1 4 1 49 HEB LOS ORPA RIKKOA P375 2 8 AAT AB 2 13 5 1 2 14 1 P376 2 4 1 P377 2 2 1 2 P378 2 6 1 2 3 4 2 7 1 2 H 2 8 KOY AZ EWKAHEGE A B C D E F 2 9 1 H 2 10 1 2 12 1 2 3 2 18 1 2 3 2 14 1 2 3 824
462. QSAR Saas HE 482 1 Fe ee a QSAR A9 3 4 MDB A9 3 4 1
463. 1 b 1 1 1 3 3 3 3 4 KEUIBES 282 A2 19 ARCHIT 3 BBC RUE GENNLF 3 3 AEE BEE ete 2A A ER ORAT Z Ob BEE ED 21 a a b ROH c 1 tt IDES d in vitro noite 1 xh e 8 RO K 3 2 1 2
464. 1 2 3 4 5 P201 2 1 3 5 1A 1B 2 3 6 1A 1B 2 3 7 1A 1B 2 3 7 P202 2 1 Ea 3 5 1A 1B 2 3 6 1A 1B 2 3 7 1A 1B 2 A B 2 2 311 1 2 3 4 5 P210 2 1 TR az ox 1 1
465. 244 1 246 GHS SE Et 1 X ERA RIEZ F 2E EUWE EKADI AERA BIT ZE EFA CRE SNCWSBGAIL GHS 1 1 1 2 1 3 1 4 1 6 BHRRELL 1 6 Ee Ra ae ieee TERA BILE argos eg BE FUL AU CILIBRR EEG ROOMS SME gt CT ARAREER 1 1 1 1 2 1 8 1 1 1 2 1 3 1 2 1 4 1 5 1 6
466. 456 7 GHS a GHS 200 1 b c d GHS GHS ii e
467. 2 7 1 2 H229 2 3 1 2 3 H230 A 2 2 H231 B 2 2 H240 2 8 HATA 2 15 H241 2 8 B 2 15 H242 2 8 2 15 C D E F 302 GHS 1 2 3 4 H250 2 9 1 2 10 H251
468. 28 pH A10 2 3 8 ne Bett H a x 1 10 100mg 1 100mg 1 OH png EI Ceo SJ Img Imm A10 3
469. 6 0mg A10 5 4 4 A10 6 A10 6 1 R Y IRUR 24 A10 6 2 AMAR LIBRO ECWET 5 A10 6 2 1 AZAR 8 7
470. DH A9 6 4 10 2 A9 6 4 11 BCF fi log Kow 5 5 Bruijn 1989 KY IAAL Jd ARS VY fe log Kow E 1log K QSAR E f 1
471. c e g tFlbund 14 22 ELALNA FERED OMNEA AFO TII SREO EMEA TEBE G E EIEE DIEE Jo LFBRDG BAUE AMO RM EFF ONE BIMA XZ EMS SE CHS 8 WE ATGBEAE WAIL ARE LMM E IL 415 O A4 3 6 3 8 A4 3 7 7 A4 8 7 1 ZELRRORODPLBE A4 8 7 1 1 a b
472. o V A6 5 2 A6 3 HRT OO L a 2 3 8 10 b 2 4 10 c 2 5 6 7 10 da 2 11 e 9 2 10 H TV 3 4 5 7 8 A oa
473. 3 1 1 2 3 RE OMAN OR FBL ELA Ee ME RERZ 3 1 1 2 3 4 ERA DEPRI E EMRET GE 3 1 3 KADEN GLE DEL EGGS 3 2 1A 1B 1C 3 2 2 REPERE FALE EIT BS 3 4 1 1A 1B WET B REPA b 3H a 3 8 1 BAOMEBLELGE P330 3 1 1 2 3 4 3 2 1A 1B 1C P331 3 2 1A 1B 1C SPER aa SHE 3 10 3 1 2 P332 3 2 2 3 P333 3 4 1 1A 1B 821
474. 3 2 3 3 2 4 TRE ars R N 527 E LKR 2 Hope ly
475. 411 A4 3 1 8 Fin OFFA E EA LOMB PT AX CHA A4 3 1 4 PRA OFS A4 8 1 5 KABB F Wee SDS my uy SDS 8 6 24 A4 3 2 2
476. MC a d 2 11 5 pH e ash in vitro v G 1 Gi 3 2 3 1 5 3 3 1 SIROTA LEGQYIDF 2 BAF CERLV GE ORE OFA ZA 3 3 3 2 38 DLE ORM OH SNR OREN a e ae 3
477. a 13 b FADS 12 1 101 3 kPa 20 C Eee iol a ce lal 101 3kPa 20 sf B 101 8kPa 20 C _ 73 EF 270 A2 3 2 3 EZAR alae
478. 3 2 2 3 4 1 1A 1B P303 2 6 1 2 3 BARE 3 2 1A 1B 1C P304 3 1 1 2 3 4 5 3 2 1A 1B 1C 3 4 1 1A 1B 3 8 3 3 8 3 P305 3 2 1A 1B 1C 3 3 1 3 3 2A 2B P306 2 18 1 2 14 1 P308 3 5 1A 1B 2 3 6 1A 1B 2 3 7 1A 1B 2 3 7 3 8 1 2 319
479. 0 1 1 4FHAOKES S HD Tit E pH Opperhuizen 1985 Anliker 1988 Opperhuizen 1986 Clit AHH Gobas 1986 1 8 WAL MecCarthy Jimenez Shrap Opperhuizen 1990
480. 2 7 1 2 2 8 AB C D E F KPI X7EHKEUSHS JIRE KHERI 2 9 1 5 2 10 1 2 12 1 2 3 2 13 1 2 3 2 14 1 2 3 P370 2 1 ech LA 1S AAs P370 2 8 BAT AB pago P375 P371 2 13 1 pag 2 14 1 es P375 328 A3 2 4 1 2 3 4 5 P401 2 1
481. 363 2 14 B HEOK 2 H272 3 Whe He H272 P210 P370 P378 P501 P220 KDBY XD EKE USES P221 Bye P280 364 2 15
482. 4 1 2 A9 2 4 4 ADEs lone A eee Ol ee log K oo log K 24 laeka Se OS E OS ee Oe BCF BCF BCF 2500
483. Corwin Hansch Overton 1901 C 4 5 1 Konemann 1981 4 K nemann Dy E 1 H log Ko B 137 QSAR Kay COLT ASF ef SAUTE QSAR gt log Ko 4 COMAINLEYEMO THEVtD b S log Ko 4 COMQIMLADRMO THEIL Overton Lipnick oye Studien ber die Narkose HR
484. OECD 1999 EPA 1996 ASTM 1999 ISO EU E 1 al E FE RA E E AR eee Vy ro GAR fC THOME FT PILZITAN DNS gt AIGRHUZSIT AR N CW SAR b EMH CE LI NOEC FLO OECD F Ter 96 E 479
485. QSAR log Kow BCF eae AA De 504 Kow E log K HI QSAR K QSAR Kov A9 5 5 4
486. 4 SDS 4 1 1 GHS SDS 1 5 GHS SDS CA GHS 4 1 2 SDS GHS 4 1 3 GHS A4 2 SDS A4 2 1 BGA e ie SDS GHS
487. ER 4 3 OPPTS 835 5270 OECD 1995 JAN Gree a al SENO D 3 2 BEDE 3 2 1 EU C 4 3 2 2 SALAS HEY a b c d e f 2 100meg 1 4 ZE OPPTS 835 2210 1 A OPPTS 835 5270 1
488. 1 BEET OPADA a 0 1 lt NOEC lt 1 mgl b 10 mg l lt L E Cs0 lt 100 mg l BCF 500 log Kow 4 2 BME LLU PADRE 10 mg l lt L E Cs0 2 100 mg l 3 HAYIOFT 2 BAF CE LV GE VRE ORAZ 4 1 3 4 4 DLREORM OBA SNL BA 3 M 1 x M x100 2 x 10 3 25 M 4 1 3 5 5 5 5 RERDO IS 1 FEL EIZ Ol CAIN THER Zl PRODRE AFT ARE AVY COL K x 1 YARLOUMBRT A Ob BCDE a VY Aro b BCF 500 og Kow 2 4 NOECs gt lmg L By gpI YS 2 EWOP ZPAF CELV GE DIRE OA ii A 3 DRE OFM OG ENR OREA UE CHIPS 4 1 2 3
489. 2 10 1 ae 4 WRITS LAO RAM CHI CE 2 12 1 2 oe 3 3 2A 2B gt 3 4 1 1A 1B P311 re 3 1 7 1 2 3 p364 ne 3 1 4 P364 3 2 2 3 4 2 1 1A 1B P370 2 4 1 a Moo ees 327 1 2 3 4 5 P370 2 6 1 2 3 4 ies pare
490. 2 14 1 2 3 2 15 A B C D E F 3 1 1 2 3 4 bRIEFLIRBRKEVET D E 3 2 1A 1B 1C REF ILSRLLO REE EPET 3 2 2 REFR oe 8 4 ND ee 3 3 1 aes 7 HETS N Bil it lt tare E T 8 3 BE 2A eee pel a 317 1 2 3 4 5 P280 3 5 1A 1B 2 HEX 3 6 1A 1B 2 3 7 1A 1B 2 P282 2 5 P283 2 13 1 2 14 1 P284
491. 8 8 2 a b c 70 DOC 3 nue ThOD E gt 60 1 OECD 302A C OF 3 3 3 E OECD 3 3 4 4 3 3 5 OECD OECD 4 301C 3
492. E 10 10 s5 A9 7 1 5 DAER k UER log Kw b EK BH ABT CAD KIEA E PED IR WIZ Ji Be A9 7 1 6 E ZAHBSD 3
493. E en DFADKE QA ean ee eae wy net 700 MR 1 PAYA La 1 aC Oa Gatien E 20 NN a TS S
494. HF EAU D EMERE a Amie 503 HF J Pj pet A dk R CC Kow Tolls 1998 Tolls 1998 1 log Kov 1989 log Kow Tolls 1998 A9 5 4 FET SEFT 2LBLUF SOKA A9 5 4 1 FSS BCF
495. PaCO 7 2 7 glem3 0 887 0 890 2 8 1 5 04 2 9 IRIE mg kg C 2 10 mg kg C 0 99 w w 2 11 Jog Pow 2 12 CC 81 7 90 6 v v 1 2 8 4 CC 2 18 2 14 2 15 A8 4 A8 4 1 AIEE A8 4 1 1 0 GHS 4 300 2000 mg kg LD mg kg 7 1480 2 1500 HE 8 FT meee LD EGHE 0 89 g cm ml kg 740 WE A8 4 1 2 KA 0 5mgL LCs mg ew 83 ppm FEL
496. E wz A E 1 1 2 2 WHEE A AYO LE Cs 10mg 100mg l E LE RUA 3 FI FNL h OVER ACRA B E 3 HE 4 JB D L E Cs0 25 100 mg l 7 a b c A9 7 5 3 3 3 28
497. EZK 28 log ke 1 69 0 53log Kow Gobas 5 1989 d Im 1 0 95 kz BCF E OECD OECD 305 1996 ASTM M ASTM E E Sed BL SAUCY DS RRR SoG H DIAM Peia e I lt etk 2 log ke 1 47 0 41 log Kow Spacie 95
498. HAOR BEA ALIA DF HH A9 3 3 4 EDTA HH 4 4 NESE ORM HH 4 FO ECx Img E
499. OECD 305 1996 MPN BCF 500 4 1 1 A9 5 2 3 9 pee t Pedersen 5 BCF RHH BCF j BCF NN es OECD 305 ae k Sa
500. i Es is UEN GHS OFF GHS 100 G RM iii iv EL Ff f IO 1 E 3
501. 2 4 2 K 2 3 3 1 835 2210 2 50cm
502. 2 800 HPV A9 6 4 5 SIDS Rd AS 1 Ge Ga Ade Hie SO A9 6 4 6 St ee ok
503. 305 GHS 1 2 3 4 H301 3 1 3 8 1 H331 H311 3 1 3 8 1 H331 H301 3 1 3 3 1 H311 3 1 H331 H302 3 1 4 8 1 H312 H302 8 1 4 3 1 H332 H312 3 1 4
504. 37 44 um 10 l Ale A10 5 2 3 3 pH 3 E 1 30 pH CO gt 1 WEES Ze ETF gt SB AA 11 20 28C 1 5C H 100mg 5 24
505. Sijm 5 1993 E k Sijm Linde 1995 Opperhuizen Sijm 1990 1 2 E z Sijm Linde 1995 E ECETOC 1995 1985 E i BROKE HDB Black 5 535
506. b c 9 1 PERORRT 2 ODSLER MIOES a 4 in vitro 7 4 2 3 4 3 2 K TIFE CHIEDI K 3 2 2 3 2 3 2 G 17 2 HEYQOR 2 BAF CELLU GE ORE OMA AT 3 DRE ORANG ENR GE a 2
507. 2 20 2 K A6 3 60 120 30 45 45 75 75 105 20 30 20 30 20 30 45 75 30 30 45 120 180 gt lo a on Alo mle ji 445 A6 5 12 A6 5 12 1 KI Dif Ml E 2 FIE A6 5 12 2 a b c d A6 5 12 3 Fi FAL FF
508. 3 A9 7 5 2 4 2 28 A9 7 5 2 4 1 1 4 2 3 4 28 NOEC A9 7 5 8 PEDIA A9 7 5 3 1 L E Cso 100mg A9 7 5 3 2 gt L E Cso A9 7 5 3 2 1 24 LEC
509. 3 pm RE 4 QS ppm DRR CRM CaS EMEC 6 85 ppm 8 oe 8 85 ppm lt 462 A8 4 1 3 EK GHS 3 200 1000 mg kg LD5 mg kg 790 2 720 HE 24 3560 mg kg 2 8 830 HE SA 14 Adee 7
510. Ay TR RO EHS MORNE A F E 1 IZ JER E E I lt RIRI ZS E eee SDS SDS E FAA a CAG 1H Bae SDS 8 ATH N VED ABE ICID CEED H MES NSB
511. C lt 16 28 28 70 lt 16 E 60 70 E 70 28 e BODs COD BODs COD 0 5 7 28 3 DS ala ABIL HEREOF BRW CME E I DUEVHEERIT 3 AE BRORLGRG ER L TORS TILEY 497 PZZ OFAI BER CW BW REEF
512. P310 P321 FR SEGA FINALE EIT BRET SY LUT PAN P305 P351 P338 381 3 2 2 H315 P264 P302 P352 P280 4
513. QSAR Kw A9 5 2 4 8 QSAR log Kow Kow Kov QSAR CLOGP LOGKOW AUTOLOGP SPARC SPARC 4 PC CLOGP LOGKOW KOWWIN AUTOLOGP SPARC log Kow CLOGP HH E QSAR US EPA EC
514. a LS aes VY Bie OM rE Neca Lupe HH Wate DEYO BCF BH A BCE BA F 1995 EDY BCF aa A9 5 2 3 9 2 BCF BCF 4 A9 5 2 3 9 3
515. b 7 K 3 3 2 2 3 3 3 2 2B 3 OR EORAIP RH SHAVES 2 a nest 2B i 1 1 3 A GD 2 10 Gi 10x 1 2 10 b 2B ena atte 2 3 3 3 3 4 284 A2 20 3 4 1 ER ORAT Z OD 5 BEDRA a
516. hte Lt a eae He ya I 4 48 96 US EPA OPPTS 850 1035 21 E 1 211 E SEAN AA E MERE OECD 210 FOl US E E ESN EARTE
517. oe Fa ww 0 005 ml es 1 3 2 8 8 100 BAI ic ee 24 48 72 0 5 7 60 1 5 1 5 A8 4 4 ABE EMS L WR AE ELE A8 4 5 A8 4 5 1 HINES BIC L SBI FYE EIIE BEL SFE ASAE
518. 4 3 2 2 3 4 1 1A 1B P363 3 2 1A 1B 1C P364 3 1 1 2 3 4 3 2 2 3 4 1 1A 1B P370 2 1 1 1 1 2 1 3 1 4 1 5 2 4 1 2 6 H 1 2 3 4 2 7 1 2 2 8 A B C D E F 2 9 1 2 10 1 2 12 1 2 3 2 13 1 2 3 2 14 1 2 3 323 1 2 3 4 5 P371 2 18 1 2 14 1 P372 2 1
519. 8 1 H332 H302 KAANE V RICHER LE OMATSZ LSS 3 1 4 3 1 H312 3 1 H332 H303 3 1 5 3 1 H313 H303 3 1 5 8 1 H333 H313 3 1 5 8 1 H333 H303 KAANE V RICHER LK OMATSZ LSS 3 1 5 3 1 H313 3 1 H333 H315 3 2 2 ORICA TS 4 HBS 72 REER 2A R H320 3 3 306 A3 1 3 GHS 1 2 4 H400
520. A4 2 2 1 SDS SDS NO Ve a SDS SDS MNO a GHS er ae SDS
521. E f 1 E PAnR RI ED GHS ER D5 BREA ALL CHEO RE FILA RUC R CLE RE RES E AAU DS ET 4 ZLo THROTLE E
522. HF X pH LN TI FA EA L E Cs0 a H 4 FE 10 L E Cso
523. Schwarzenbach 5 1993 7 TCS OME 2 3 DKA 2 8 1 HzO OH OH 2 3 2 111 pH pH j 2 OECD
524. log Kow 0 9 D log Kow TemaNord 1995 581 CLOGP LOGKOW 2 2 3 4 AUTOLOGP Devillers 1995 800 C H N O P 8S og K 1og K log Kw log Kw He FACE OD pH AUTOLOGP AUTOLOGP
525. 1 HE log Kow FAY o WB hh AN E E E PEO IE A9 6 3 2 n E HE ER A9 6 3 3 QSAR 1
526. 4 1 2 ZS HE 1 3 qe 2 lt BBE 7 1 7 6 EH 3 7 6 LEH 4 5 24 100 2 463 A8 4 8 AUZIT SEB LRG F Te THGURE a 3 GHS 1
527. A3 3 3 A3 3 3 1 if H 8 Ha RE A3 3 3 2 3 A3 3 3 8 A3 8 3 4 GHS E
528. c i ii d i ii iii iv See Hie X 1 8 A4 3 8 8 REF f H EF HH A4 3 8 1 A4 3 8 1 1 E SIZ ER E 3 Ei MAK s A4 8 8 1 2
529. log Kow pH European Commission 1996 part III log Kay 0 5 Niemela 1993 log Kos 1 1og Kw 0 9 log Kow n 501 r2 0 967 7000 CLOGP PC version 3 32 EPA version 1 2 r2 0 89 s d 0 58 n 7221 CLOGP log Kw OF E
530. 1 oe IE BEKILIZ lt BOMSRS OBA RERE FENE oR 1 2 P311 3 8 326 1 2 3 4 5 es 3 5 1A 1B 2 P313 3 6 1A 1B 2 3 7 1A 1B 2 3 7 P332 3 2 2 3 P383 P318 BISNVHZHS EXIT p3ig IRL TH HL a 3 4 1 1A 1B pg13 P335
531. 3 3 K Ale 7 4 1 E 251 1 ERETEIR DO A TEMG ECFA R fe AS F a te A 4 1 EEE BRE D R IZ TF EE EFI HAN K DRRR O R Pa ae at AN 4 252 1 2 EEE ROO RMEIZ IF SAE EFN FEO 4 1 2 8 ETER D I BIT SMG ETIA Al
532. 303A Coupled Unit ISO 117383 EU C 10 eae 1996 3 6 SEMI DAPIE 3 6 1 ISO 11734 1995 E ASTM E 1196 92 OPPTS 835 3400 3 6 2 8 a b c 35C d COz CH4 3 6 8
533. A9 7 5 3 3 2 A3 OA 28 4 A9 7 5 3 3 2 7 gt 1 TaT L E Cso 2 ae hat FAH 3 28 2 7
534. Do VET VARRILE AR Cm 0 AER LOE Lemna 221 US EPA 850 4400 kA E ECso PH 14 4 OECD E Lemna 480 ES a Lemna gibba Lemna minor E H EVE BER A9 3 3 2 QSAR TKA ALE OBES 4 E Rand 1996 A9 3 3 1 A9 3 3 1
535. OILS BERAE 3 6 1A 1B CRW EBREHICHA SH TOSHA A BOIS BET Z 304 GHS 1 2 3 4 H351 MORD OLS E 3 6 2 BAET EBRENIZHA A CWS A AECE RET D H360 5 3 7 1A 1B DAWL TS COREE ZT EIERE ANTS HA DREE D OILS BRAG CHWS E BREN CHE APU CW BEE BERE ERRET B H361 3 7 Bt 2 UDOWILT NTO ERII IMB ZE IFZ MOLERO OIF BSH ETRO E DENEA EN CWSEE HECE RRT B H362 3 7 H370 LODAITITR COLBEEZ IS 1 BIRETE MORD O OIF S BAA 3 8 ETRU EDAEN AEA SN TUBE HECE ERRATZ H371
536. P210 P306 P360 P501 P220 P221 EA P280 pi S P283 P371 P380 P375 P370 P378 kR Y AZRPIIK ARPA
537. o BIE BTE 1 TE A9 3 3 1 Se v EDA 4 E MO ITA KAM ERE BAK WOH 1 E ae a a E 2 ar hl na 4 Pe eee ME ae gt A9 3 3 2 A9 3 3 2 A9 3 3 2 3 2 PEE TELE 1
538. 2 12 1 H260 2 H261 P223 P335 P334 P402 P404 P501 P231 P232 P370 P378 P280 IKEY KD BHBK AU BGE 359
539. 501 EGE A IUTVYS US EPA EC 1993 Pedersen 1995 CLOGP LOGKOW A9 5 1 K A9 5 1 K QSAR log Kow CLOGP log Kw lt 0 C H N O P 8 log Kow gt 92 1og Kow LOGKOW 4 lt log Kw C H N 0 Si P Se Li Na K KOWWIN lt sb Hg 1og Kow AUTOLOGP log Kow gt 5 C H N 0O P 8 log Kw AUTOLOGP
540. AER ee 1 NO YES 1 e 5 L E Cso z j 2 28 AOR Amick SABER j NO A NOEC 2 L E Cso De 1 2 28 H 28 NOEC NOEC 3 4 NO 518 1 4 5 DARE Z M
541. ARAE CER BA BEBE i 2 3 5 3 2 H DLE ORAID AH ENERE 2 1 0 2 287 A2 23 3 6 ea 1 BAP LURET Z OD SUES 3 6 2 a ay y b a QA 2 BOWOF PAF CHR 1B 3 6 3 2 OLE OFA OA SRL GE 1
542. CLOGP OECD 1993 LAS Roberts 1989 2 3 8 LOGKOW KOWWIN Syracuse Research Corporation 4 5 CLOGP C H N 0 Si P Se Li Na KE Hg log Kow log Ko pH Tolls 1998 LOGKOW Pedersen 1995
543. H FUN fi I RA EP A3 3 2 3 GHS 1 4 6 3 CE EEN GHS Call Fa RTR N 1 2 1 4 335 E MEDED L lt LPR EA
544. LCso 0 5 gt 1 0 Smg l fale a Bric Hehe LES AY WATS LAEE ZR DE TAF 4 LDs 300 gt 2000 lt me ke tke EN LDso 1000 gt 2000 mg kg ER LCso 2500 gt 20000 ppm LCso 10 0 gt 20 0 mg l iy LCso 1 0 gt 5 0 mg Ab F ae i lt ad LDso a He LCso LDso 2000 gt lt RE ee TEREE mm EN IA O 4 1 a A RR c 4 sa BBE ae 279 A2 18 3 2 a c d e 1
545. LPAAMILTIR CON REEERE KEN lt 2 HER LNT SMa EATS MORD O OIF 8 8 SBRBAE CRW EBREHNC A ANT EGE HECE LETS H372 HEM MAE KEIT R 1 DAWITTR CORBLEZIT SMBH 8 9 FAITE MORD DIES BRAECE OT EDEBE AN TOSA FEE IEE 2 LRT B H373 2 6 LODRLI SCOPBEZ 3 9 VT SWAS EATS MOED DISS BA PETRO EBREMIZH SN TOB A AECE ERRET S H300 3 1 1 2 3 1 H310 H300 3 1 1 2 3 1 H330 H310 3 1 1 2 3 1 H330 H300 3 1 1 2 8 1 H310 3 1 H330 H301 RAUNT RICHER 4 LA 3 1 3 3 1 H311
546. a Sh m A2 6 2 6 EZAR lt 23 By eR LU lt 23 HHA gt 35C Z230 gt 60C 93C ee a b lt 45 gt 2 2 mm lt 5 9 ain a 4 b lt a gt 2 2mm gt 5 y 10 273 A2 8 2 8 DMEM OWEIAIT E
547. 1 4 7 2 10 15ml A10 5 1 10 pH L ERE A10 5 1 10 J 28 7 E 1 2 2 2 A10 5 1 6 A10 5 1 8 10 15ml H 7 pH 5 L ER a 2 3
548. 1 ca et ul a SP 2S d 1 285 A2 21 3 4 Io 1 DAR URAT Z D EEDA a b VN SS 3 4 3 2 3 OEDFA SNA A ESM POD a 0 1 7 K 3 4 5 b 1 0 BAR NRT 2 Ob 5 CADRE E P CREED ONSBLOVE EM en
549. 1A 1B H334 P261 P304 P340 P501 P260 BINS Hd AH SAANZILAUR LT P342 P311 P284 OXF Fits OLE UAZLYT B LU ERRE ZEBTMNESA OF ONZA DS CBF J Mixi DEA FEB LCWSBBNE AL TERI 387
550. 2 BCF oe K AHH eee 0SP SN i MS E BCF BCF 1 H BCF BCF 59
551. 200 1 4 10 5 2 d BFR 2 a 1 4 10 5 2 b 1 4 10 5 2 c 1 4 10 5 2 e a GHS LE EGR AOMEIKET SME A ICED B IIKRO MUB L ORRIRA PURINA CEPT 3 EBCE S 454 5 1 2 1 4 10 5 2 a 1 4 10 5 2 1 4 10 5 2 c 1 4 10 5 2 e ea GHS BEERDA BT SIE CF ARA IZED B FIKK FEXLBLORFRILMAR DURA CHRIS CE EBCEZ Ss 455 6 2 2 A onl 1 4 10 5 2 d 1 4 10 5 2 a 1 4 10 5 2 1 4 10 5 2 c BFR 1 4 10 5 2 e
552. 3 1 4 pay ee 3 2 1A 1B 1C P330 4 P331 P302 2 9 1 Pag4 BACH e 325 SR 1 2 3 4 5 ve 3 1 1 2 3 4 Gace oes 3 2 2 3 4 1 1A 1B oe 2 6 1 2 3 Ps61
553. A8 4 5 2 A8 4 5 2 1 EA A8 4 5 2 2 0 43mgl 72ppm 13 RITS BOL SAE 1 ED GHS GHS NOEL mg F344 0 12 6 13 3 20 0 24 JO UE SATE
554. BLO FILS ORM bSVVLECORFOMGI Ss CC EM HUZ EBT ELED DS 538 ISO 10707 1994 Water quality Evaluation in an aqueous medium of the ultimate biodegradability of organic compounds Method by analysis of biochemical oxygen demand closed bottle test ISO 11348 1997 Water quality Determination of the inhibitory effect of water samples on the light emission of Vibrio fischeri Luminescent bacteria test ISO 11733 1994 Water quality Evaluation of the elimination and biodegradability of organic compounds in an aqueous medium Activated sludge simulation test ISO 11734 1995 Water quality Evaluation of the ultimate anaerobic biodegradability of organic compounds in digested sludge Method by measurement of the biogas production ISO DIS 14592 1999 Water quality Evaluation of the aerobic biodegradability of organic compounds at low concentrations in water Part 1 Shake flask batch test with surface water or surface water sediment suspensions 22 11 1999 OECD Test Guideline 111 1981 Hydrolysis as a function of pH OECD guidelines for testing of chemicals OECD Test Guideline 209 1984 Activated sludge respiration inhibition test OECD guidelines for testing of chemicals OECD Test Guideline 301 1992 Ready biodegradability OECD guidelines for testing of chemicals OECD Test Guideline 302A 1981 Inherent biodegradability Modified SCAS OECD guidelines for testing of chemicals OECD
555. 1 2 1 3 1 4 1 5 Se 2 2 1 2 2 3 1 2 3 2 6 1 2 3 2 7 1 2 2 8 A B C D E F 2 9 1 q 2 10 1 2 15 A B C D E F 2 6 4 IPAO b D264 SIF S Z E ATT EE 2 13 1 2 3 P T E se 2 14 3 1 2 3 vias A P211 2 3 1 2 P220 2 4 1 a 2 8 ERIM eB 4 Ly HA 4a A TE H A B C D E F FFD 2 13 2 3 2 14 2 8 2 15 A B C D E F 2 13 1 LRP Ri DRETZ HAR eS 2 14 2 1 EN I EE P221 2 13 1 2 3 GR a E LATE E 2 14 1 2 3 312
556. 1 3 5 5 5 5 BLERAO J b 1 FERAL LIZ OU CHA PIRETRO Lev CADRA KE CE SIAR AVY CORAL x 1 REMET OPADIE a 0 01 lt NOEC lt 1 mg l b 1 mgl lt L R Cso lt 10 mg l BCF 2 500 14 log Kow 2 4 2 REPEL PADRE a 0 1 lt NOEC lt 1 mgl b 1 mgl lt L E Cso lt 10 mg l 5 3 BEYOF 2 BAF T R GE OFF EF DRAN 4 1 3 4 4 DREORMD GT SPU BA 2 1 x M x 10 2 25 M 4 1 3 5 5 5 i 5 ALERAO J 1AL EIO CA TREN IR x 3 T OREIKES 295 A2 28 b 2XKERGBIER BIE GRWP 41 BLE EX
557. 1988 Physical chemical properties of chlorinated dibenzo p dioxins Environ Sci Technol 22 pages 651 658 Sym D T H M van der Linde A 1995 Size dependent bioconcentration kinetics of hydrophobic organic chemicals in fish based on diffusive mass transfer and allometric relationships Environ Sci Technol 29 2769 2777 Sym D T H M Part P Opperhuizen A 1993 The influence of temperature on the uptake rate constants of hydrophobic compounds determined by the isolated perfused gill of rainbow trout Oncorhynchus mykiss Aquat Toxicol 25 1 14 Spacie A Hamelink J L 1982 Alternative models for describing the bioconcentration of organics in fish Environ Toxicol Chem 1 309 320 Suzuki T Kudo Y J 1990 J Computer Aided Molecular Design 4 155 198 Syracuse Research Corporation 1999 Tas J W Seinen W Opperhuizen A 1991 Lethal body burden of triphenyltin chloride in fish Preliminary results Comp Biochem Physiol 100C 1 2 59 60 Tolls J amp Sijm D T H M 1993 Bioconcentration of surfactants RITOX the Netherlands 9 Nov 1993 Procter and Gamble Report ed M Stalmans Tolls J 1998 Bioconcentration of surfactants Ph D Thesis Utrecht University Utrecht The Netherlands Toshima S Moriya T Yoshimura K 1992 Effects of polyoxyethylene 20 sorbitan monooleate on the acute toxicity of linear alkylbenzenesulfonate Ci2 LAS to fish Ecotoxicol Environ Safety 24 26 36 USEPA 1985 U
558. 5 Degradation biochemical oxygen demand Directive 67 548 EEC Annex V 1992 EC C 7 Degradation abiotic degradation hydrolysis as a function of pH Directive 67 548 EEC Annex V 1992 EC C 9 Biodegradation Zahn Wellens test Directive 67 548 EEC Annex V 1988 EC C 10 Biodegradation Activated sludge simulation tests Directive 67 548 EEC Annex V 1998 EC C 11 Biodegradation Activated sludge respiration inhibition test Directive 67 548 EEC Annex V 1988 EC C 12 Biodegradation Modified SCAS test Directive 67 548 EEC Annex V 1998 ISO 9408 1991 Water quality Evaluation in an aqueous medium of the ultimate biodegradability of organic compounds Method by determining the oxygen demand in a closed respirometer ISO 9439 1990 Water quality Evaluation in an aqueous medium of the ultimate biodegradability of organic compounds Method by analysis of released carbon dioxide ISO 9509 1996 Water quality Method for assessing the inhibition of nutrification of activated sludge micro organisms by chemicals and wastewaters ISO 9887 1992 Water quality Evaluation of the aerobic biodegradability of organic compounds in an aqueous medium Semicontinuous activated sludge method SCAS ISO 9888 1991 Water quality Evaluation of the aerobic biodegradability of organic compounds in an aqueous medium Static test Zahn Wellens method 2 LLFOY X bl 2000 9 AVERDODBDCHY
559. A10 5 1 6 A10 5 1 8 A10 4 PR de SIRE ATEN pH 559 k 1 m n o p 560 10 11 10 Draft Report of the OECD Workshop on Aquatic Toxicity Testing of Sparmgly Soluble Metals Inorganic Metal Compounds and Minerals Sept 5 8 1995 Ottawa OECD Metals Working Group Meeting Pari
560. HEIL E Pi E ice HRD EE f 4 E E E GHS F VATAR OECD 1998 4 C AY ABA 1 FE CO 96 HR LCs0 fh OECD 208 EEIE HUT 7 RECO 48 ISR EC ff OECD BIL 202 I IIRA 7 FE CO 72 FREZI 96 FFR ECso ff OECD 201 FKALAEO DD ICLVOKRESHS IDLKEWPILT S COKELEMHONK CHE EARRESHSB PRLE ZKR b OTOMI BRAHSZH Lemna
561. Kow b log Kov A9 5 5 HEXF A A9 5 5 1 log Kow Kow A9 5 5 2 BCF BCF BCE BCF A9 5 5 8
562. LIZ OU CHA REI FR ECDL AFT OPREAVWY CHL K x 1 RR ae SECDHA E 1mgl lt L E Cso lt 10 mg l ee L BOCso 96 LCso 48 pe craze ECsyLCso 72 96 EMA ErCso LAYOFF 2 BAF CAAV GE ORE ORE AM 2 4 1 3 4 3 LE ORD ELL GE a AES idea tale chee 4 1 3 5 5 2 1 x M x10 2 25 M 4 1 3 5 5 5 b 4 1 3 5 2 4 1 3 5 3 2 1 mg l lt LE Cso lt 10 mg l lt c
563. LTTE ZRNI TTILE EV DEAE CHBEDEIPREWIZE CHS EE IEE ERBRICIL Zahn Wellen HR OECD TG 302 B amp MITI II RW OECD TG 302 BHS fE FAEPELEL POE BY BRITS BLE UE LE BABEAV TILES ZU b CHEROMBIZBI CT HUEFFENLIR 5S FLEE Ch HROPVTAEIL THN ABLN ERZAN LVEF SVFFHLCH CHE FOL I CHS MITI 77 AHEL NIL gt 60 14 HELA Gi Zahn Wellen RW gt 70 7 AL 493 4 A9 4 2 4 18 F BOR k OECD 1997 tue lt 2 3 H 4 WE EE E A9 4 2 4 14 i A9 4 2 4 14 1
564. P380 P401 P501 PUKK DO DL IREK POR P372 P230 RE E TERT AE RIT LEELLGB EPRE EHR E OREFERIEDBIST EAE A he P240 RIED DS RA EANET OBAE P250 P280 P373 339
565. SHAD TJ Cs dy AR VEE A9 4 2 2 3 gt eS 28 H OECD 4 SN 28 H PRL 1 A9 4 2 3 BODsCOD 5 2 14
566. SME EFL HARES vy See ETER DR I TF SbMG EJIL HATIRA ES VT 1 2 ESE OO Wh lZ AF TIRE gt EFNA MITE 2 7 NO oa 250 BATA B C D EEF G BROBELLU i canes as YT SME ETB 0 1 B ERO OMEICT SME ET AANCHES lt RAE 181 2
567. Test Guideline 302B 1992 Zahn Wellens EMPA test OECD guidelines for testing of chemicals OECD Test Guideline 302C 1981 Inherent Biodegradability Modified MITI test II OECD guidelines for testing of chemicals OECD Test Guideline 303A 1981 Simulation test aerobic sewage treatment Coupled units test OECD guidelines for testing of chemicals 1999 OECD Test Guideline 304A 1981 Inherent biodegradability in soil OECD guidelines for testing of chemicals OECD Test Guideline 306 1992 Biodegradability in seawater OECD guidelines for testing of chemicals OECD 1998 Aerobic and anaerobic transformation in aquatic sediment systems 1999 12 OECD 1999 Aerobic and anaerobic transformation in soil 1999 10 OECD 2000 Simulation test Aerobic Transformation in Surface Water 2000 5 OPPTS 835 2110 Hydrolysis as a function of pH OPPTS 835 2130 Hydrolysis as a function of pH and temperature OPPTS 835 2210 Direct photolysis rate in water by sunlight OPPTS 835 3110 Ready biodegradability OPPTS 835 3170 Shake flask die away test OPPTS 835 3180 Sediment water microcosm biodegradability test OPPTS 835 3200 Zahn Wellens EMPA test OPPTS 835 3210 Modified SCAS test OPPTS 835
568. ce ee Dat A9 3 A9 2 6 3 MC ZN H 4 B L B 4 E E
569. g AME 24 ELW OMS FOE E E OECD 202 3 28 IIE lt T D OECD A E E GAT OECD 201 EA 3 4 A9 3 2 7 2 4 FX
570. 0 KC MgSO 7H20 DIREZ ISO6341 OBIKO 5 BO WEF CRITFUL FRAN REWIENLE M ARRELIRINT AUF BIZ OZC 2 7 DA A EMRAN BOTHH CHS 554 A10 1 NaHCOs 6 5 mg l 12 6mg l 64 75mg l 194 25mg l KCl 0 58mg l 2 32mg 1 5 75mg 5 74mg CaCls 2HzO 29 4mg l 117 6mg l 294mg 29 4mg l MgSO4 7HzO 12 3mg 49 2mg1 123 25mg l 123 25mg l CORE 0 50 0 10 0 038 K 0 038 pH 6 09 7 07 7 98 8 5 Yt 1 pH 4 FACT Facility for the Analysis of Chemical Thermodynamics http www erct polymtl ca tactfact htm A THALE bO CHS te 2 pH Hf 6 0 8 0 22 COR G HED GB AA COW SDS AKII pH5 5 H45 DEMS DOTIAU pH8 5 OHAKIL BB F CILAN ATH AF TU 220 A10 5 1 8 pH A10 5 1 9
571. 2 SEBRATIC FE ty Fil kd KE B E n Ko E K y HH HH Ko WE Stic Kow 3 QSAR Ko A9 5 2 8 AMR TAL BCP A9 5 2 3 1 BCF
572. 3 4 1 1 2 3 LEE LMELIIM LE 4 1 1 2 3 4 aie 316 1 2 3 4 5 P280 2 1 PRM ETET D E 1 1 1 2 1 3 1 4 1 5 2 6 1 2 3 4 EIL TE T een ie 2 7 1 2 a 2 8 AA A B C D E F 2 9 1 2 10 1 2 11 1 2 2 12 1 2 3 2 13 1 2 3
573. 3300 Soil biodegradation OPPTS 835 3400 Anaerobic biodegradability of organic chemicals OPPTS 835 5270 Indirect photolysis screening test Sunlight photolysis in waters containing dissolved humic substances 539 4 ASTM 1993 ASTM Standards on Aquatic Toxicology and Hazard Evaluation Sponsored by ASTM Committee E 47 on Biological Effects and Environmental Fate American Society for Testing and Materials 1916 Race Street Philadelphia PA 19103 ASTM PCN 03 547093 16 ISBN 0 8032 1778 7 ASTM E 1022 94 1997 Standard Guide for Conducting Bioconcentration Tests with Fishes and Saltwater Bivalve Molluscs American Society for Testing and Materials EC 1992 EC A 8 Partition coefficient Annex V Directive 67 548 EEC Methods for determination of physico chemical properties toxicity and ecotoxicity EC 1998 EC C 13 Bioconcentration Flow through Fish Test EPA OTS 1982 Guidelines and support documents for environmental effects testing Chemical fate test guidelines and support documents United States Environmental Protection Agency Office of Pesticides and Toxic Substances Washington D C 20960 EPA 560 6 82 002 1982 8 Code of Federal Regulations Protection of the Environment Part 790 1998 7 1
574. 8 1 1 GHS 0 EL Ti GHS SDS SDS SDS A4 3 1 2 fEDFFEFR SA 7 4TH E12 69 BRAIT LNI EPOS EII SDS
575. A4 8 14 4 ATORE BSR N A4 3 14 5 REH EHE IMDG code ADR RID ADN A4 8 14 6 AFOXOORW TBE x A4 3 14 7 MARPOL73 78 II9 TIBC Code iZ IMO MARPOL73 78 II TIBC Code
576. BHO K E 844 2 3 KR 1 H222 H229 2 H228 H229 P210 P410 P412 BWATEIEUAIIEO bO OL 5 READE DY OK 50 C LL LOWRIE lt BUR P211 P251 945 2 3 BL 3 H229 P210 P410 P412 BVATELAIRIEO DO DL I REAR DDR 50 C
577. CWE EBERT EE A4 3 3 1 FBA A4 3 3 1 1 LF GAEOL FHES GHS DERE MIR ERE I LEECT MEFCASLEE RIUPACS TEV A4 3 3 1 2 A4 8 3 1 8 147 A4 3 3 1 4 ZUAR EF VA OWA ENA E Fy D CAS REE ZOWMODOREE CAS RC Ae Do BEA TE REDO PFOA OFU AT O FMD E PREBERI A4 3 3 2 HAH A4 3 3 2 1 GHS
578. Cs H HPLC H en FF Kov 2 AME F 225 ro log Kw ras AL os a log ae 4 5 Doucette Andren 1987 1988 Shiu 5 1988 Toxic Substances gt lt ae a IESCA H OECD 107 1995
579. D OECD 301E ee OECD 301 496 A9 4 3 5 6 ORCD 301D MITI I OECD 3010 OECD 301F A9 4 3 6 RRF A TBII ABS 1 i E
580. EE BRIE L OF ag aC HERE 2 8 2 8 4 1 eS REER DIMZ BIT SHE PARRE O HEZE 2 8 2 8 4 1 EE GO WE TIT SHE PRISLO HEZ 2 8 2 8 4 1 ETE RA OMELET SHE PRISLO HEZ TT 2 8 2 8 4 1 LESTER OW ET SHG PARLO DEBRA FHKE HEZE RECE ILI RAEREF OH 2 8 2 8 4 1 EVIL ZL VY ft Fa T 274 A2 9 2 9 eile 52 2
581. EEDO LIE 3 8 1 Syracuse Research Corporation Biodegradability Probability Program BIOWIN OECD 1993 peas 1996 Biodegradability Probability Program BIOWIN Bo E m pi US EPA EC SAR OECD 1994 Pedersen 5 1995 3 8 2 MITI 1992
582. ERF FA A9 5 3 1 BCF log Kow A9 5 8 2 ARABELBA A9 5 3 2 1 DoE 1996 ECETOC 1996 US EPA 1996 OECD OECD 2000 OECD
583. Et MO RL HE L E
584. F PS EE Peterson Keenen nies kg 22 AGH SDL 2 3 fH 2 3 1
585. I THN BELE I 2 12 R hyD HRVARRIL REEERE TRA AIC BITER h y DPHRVARWEW J 13 PyFARABKL JEF OJR E LSTEDRELYAR L ORAN OU COBMODONWRIZTED S ED FRE ICBIT SE E y FUF ARNE 2 425 426 5 428 A5 1 FF A5 1 1 ARS 1998 RE D4 ao a 1 8 Son 1 5 E Ay REDI Et EDAR OR NN Abbt Fm E BRAT PUL COMPOXRERETS EDS WHE A5 1 2 ae ULSD GHS
586. INNS De WHAM Tipping 1994 fi A9 7 2 2 REET OME A9 7 2 2 1 YRRREICRB LCA FANE F FICOWCHEBT AGF ZOI A9 7 2 2 2 3 A pH EK BS E CAM A9 7 2 2 8
587. LLER DB 540 9 VI 1 APHA 1992 Standard Methods for the Examination of Water and Wastewater 18th edition American Public Health Association Washington DC ASTM 1999 Annual Book of ASTM standards Vol 11 04 American Society for Testing and Materials Philadelphia PA DoE 1996 Guidance on the Aquatic Toxicity Testing of Difficult Substances United Kingdom Department of the Environment London ECETOC 1996 Aquatic Toxicity Testing of Sparingly Soluble Volatile and Unstable Substances ECETOC Monograph No 26 ECETOC Brussels Lewis M A 1995 Algae and vascular plant tests In Rand G M ed 1995 Fundamentals of Aquatic Toxicology Second Edition Taylor amp Francis Washington DC pp 135 169 Mensink B J W G M Montforts L Wijkhuizen Maslankiewicz H Tibosch and J B H J Linders 1995 Manual for Summarising and Evaluating the Environmental Aspects of Pesticides Report No 679101022 RIVM Bilthoven The Netherlands OECD 1998 Harmonized Integrated Hazard Classification System for Human Health and Environmental Effects of Chemical Substances OECD Paris Document ENV JM MONO 2001 6 OECD 1999 Guidelines for Testing of Chemicals Organisation for Economic Co operation and Development Paris OECD 2000 Revised Draft Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures OECD Paris OECD 2006 Current approaches in
588. O4 7HzO 123mg l pH pH A10 5 1 7 A10 5 1 4 _ 2 0mg l A10 5 1 5 v NaF 8mg 1 SrCls 6 H20 20mg l HsBO3 30mg KBr 100mg l KCl 700mg CaCls 2 H20 1 47g l NasSO4 4 0g l MgCls 6 H20 10 78g l NaCl 23 5 1 NasSi0s 9 H20 20mg 1 NaHCOs 200mg 1 34 0 5gykg pH 8 0 0 2 ASTM E 729 96 A10 5 1 6 pH
589. P C Opperhuizen A Hutzinger O 1986 Bioconcentration of hydrophobic chemicals in fish Relationship with membrane permeation Environ Toxicol Chem 5 637 646 543 Gobas FA P C Clark K E Shiu W Y Mackay D 1989 Bioconcentration of polybrominated benzenes and biphenyls and related superhydrophobic chemicals in fish Role of bioavailability and elimination into feces Environ Toxicol Chem 8 231 245 Goodrich M S Melancon M J Davis R A Lech J J 1991 The toxicity bioaccumulation metabolism and elimination of dioctyl sodium sulfosuccinate DSS in rainbow trout Oncorhynchus mykiss Water Res 25 119 124 Hansch C Leo A 1979 Substituent constants for correlation analysis in chemistry and biology Wiley New York NY 1979 Henderson R J Tocher D R 1987 The lipid composition and biochemistry of freshwater fish Prog Lipid Res 26 281 347 Howard P H and Meyland W M 1997 Prediction of physical properties transport and degradation for environmental fate and exposure assessments QSAR in environmental science VII Eds Chen F and Schuurmann G pp 185 205 Kimerle R A Swisher R D Schroeder Comotto R M 1975 Surfactant structure and aquatic toxicity Symposium on Structure Activity correlations in Studies on Toxicity and Bioconcentration with Aquatic Organisms Burlington Ontario Canada pp 22 35 Klopman G Li J Y Wang S Dimayuga M 1994 Computer automated log P calculations
590. P240 PERMA EAL IT GE BEB DER ECKE IEF SUD IEE TESHA P241 P242 P243 P280 BRE P370 P378 KIY KZ EHIK AH SEE BAD
591. R E E F PS g X log 1990 1b ORE FE TEH K A9 6 8 QSAR EFN ORUE A9 6 3 1 HE amp ZS One 1 QSAR E 1 ASIC eA FA E
592. R JE S IVT VFR 6 2 6 258 1A 1B 1C 2 3 ENREDO TEER OD BB IT SMEG EP AUTAR S NTAN N T p a pe gt 8 ta RSA P 1 2A 2B ERRORE FETE RO DWMIEIZ BIT DE ETNA ITRE SIV TVR 259 1 1A 1B
593. S Environmental Protection Agency Office of Toxic Substances Toxic Substances Control Act Test Guidelines 50 FR 39252 US EPA EC 1993 US EPA EC Joint Project on the Evaluation of Quantitative Structure Activity Relationships 545 US EPA 1996 Ecological effects test guidelines OPPTS 850 1000 Special considerations for conducting aquatic laboratory studies Public Draft EPA712 C 96 113 United States Environmental Protection Agency http www epa gov opptsfrs home testmeth htm Van Den Berg M Van De Meet D Peijnenburg W J G M Sijm D T H M Struijs J Tas J W 1995 Transport accumulation and transformation processes In Risk Assessment of Chemicals An Introduction van Leeuwen C J Hermens J L M eds Dordrecht NL Kluwer Academic Publishers 37 102 Wakabayashi M Kikuchi M Sato A Yoshida T 1987 Bioconcentration of alcohol ethoxylates in carp Cyprinus carpio Ecotoxicol Environ Safety 13 148 163 Wofford H W C D Wilsey G S Neff C S Giam amp J M Neff 1981 Bioaccumulation and metabolism of phthalate esters by oysters brown shrimp and sheepshead minnows Ecotox Environ Safety 5 202 210 1981 4 QSAR Boethling R S Howard P H Meylan W M Stiteler W M Beauman J A and Tirado N 1994 Group contribution method for predicting probability and rate of aerobic biodegradation Envir Sci Technol 28 459 465 De Bruijn J Busser F Se
594. Sijm D T H M 1990 Bioaccumulation and biotransformation of polychlorinated dibenzo p dioxins and dibenzofurans in fish Environ Toxicol Chem 9 175 186 Pedersen F Tyle H Niemel J R Guttmann B Lander L and Wedebrand A 1995 Environmental Hazard Classification data collection and interpretation guide 2nd edition TemaNord 1995 581 Petersen G I Kristensen P 1998 Bioaccumulation of lipophilic substances in fish early life stages Environ Toxicol Chem 17 7 1385 1395 Rekker R F de Kort H M 1979 The hydrophobic fragmental constant An extension to a 1000 data point set Eur J Med Chem Chim Ther 14 479 488 Roberts D W 1989 Aquatic toxicity of linear alkyl benzene sulphonates LAS a QSAR analysis Communicaciones Presentadas a las Jornadas del Comite Espanol de la Detergencia 20 1989 35 43 Also in J E Turner M W England T W Schultz and N J Kwaak eds QSAR 88 Proc Third International Workshop on Qualitative Structure Activity Relationships in Environmental Toxicology 22 26 May 1988 Knoxville Tennessee pp 91 98 Available from the National Technical Information Service US Dept of Commerce Springfield VA Schrap S M Opperhuizen A 1990 Relationship between bioavailability and hydrophobicity reduction of the uptake of organic chemicals by fish due to the sorption of particles Environ Toxicol Chem 9 715 724 Shiu WY Doucette W Gobas FAPC Andren A Mackay D
595. Toxicol Chem 11 893 900 Niimi A J 1991 Solubility of organic chemicals in octanol triolin and cod liver oil and relationships between solubility and partition coefficients Wat Res 25 1515 1521 OECD 1993 Application of structure activity relationships to the estimation of properties important in exposure assessment OECD Environment Directorate Environment Monograph No 67 OECD 1998 Harmonized integrated hazard classification system for human health and environmental effects of chemical substances As endorsed by the 28 joint meeting of the chemicals committee and the working party on chemicals in November 1998 OECD 2000 Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures OECD Paris Opperhuizen A Van der Velde E W Gobas F A P C Liem A K D Van der Steen J M D Hutzinger O 1985 Relationship between bioconcentration in fish and steric factors of hydrophobic chemicals Chemosphere 14 1871 1896 544 Opperhuizen A 1986 Bioconcentration of hydrophobic chemicals in fish In Poston T M Purdy R eds Aquatic Toxicology and Environmental Fate Ninth Volume ASTM STP 921 American Society for Testing and Materials Philadelphia PA 304 315 Opperhuizen A Schrap S M 1987 Relationship between aqueous oxygen concentration and uptake and elimination rates during bioconcentration of hydrophobic chemicals in fish Environ Toxicol Chemosphere 6 335 342 Opperhuizen A
596. abelling of household chemicals Consumer Safety Institute Amsterdam Leen Petre 1994 Safety information on dangerous products consumer assessment COFACE Brussels Belgium European Commission 1999 DGIII Study on Comprehensibility of labels based on Directive 88 8797 EEC on Dangerous Preparations Magat W A W K Viscusi and J Huber 1988 Consumer processing of hazard warning information Journal of Risk and Uncertainty 1 201 232 Abt Associates Inc 1999 Consumer Labelling Initiative Phase II Report Cambridge Massachusetts Prepared for US EPA Viscusi W K 1991 Toward a proper role for hazard warnings in products lability cases Journal of Products Liability 13 189 1638 US Consumer Product safety Commission 2001 Code of Federal Regulations Subchapter C Federal Hazardous Substances Act Regulations 16 Part 1500 Saouter E G Van Hoof C Pittinger and T Feijtel 2000 A retrospective analysis of the environmental protile of laundry detergents submitted to International Journal of life cycle analysis October 2000 IPCS 2001 Principles for evaluating health risks to reproduction associated with exposure to chemicals Environmental Health Criteria No 225 IPCS 2000 Human exposure assessment Environmental Health Criteria No 214 IPCS 1999 Principles for assessment of risks to human health from exposure to chemicals Environmental Health Criteria No 210 432 6
597. based on an extended group contribution approach J Chem Inf Comput Sci 34 752 781 Knezovich J P Lawton M P Inoue L S 1989 Bioaccumulation and tissue distribution of a quaternary ammonium surfactant in three aquatic species Bull Environ Contam Toxicol 42 87 93 Knezovich J P Inoue L S 1993 The influence of sediment and colloidal material on the bioavailability of a quaternary ammonium surfactant Ecotoxicol Environ Safety 26 253 264 Kristensen P 1991 Bioconcentration in fish Comparison of BCFs derived from OECD and ASTM testing methods influence of particulate matter to the bioavailability of chemicals Danish Water Quality Institute Mackay D 1982 Correlation of bioconcentration factors Environ Sci Technol 16 274 278 McCarthy J F Jimenez B D 1985 Reduction in bioavailability to bluegills of polycyclic aromatic hydrocarbons bound to dissolved humic material Environ Toxicol Chem 4 511 521 McKim J M Goeden H M 1982 A direct measure of the uptake efficiency of a xenobiotic chemical across the gill of brook trout Sa velinus fontinalis under normoxic and hypoxic conditions Comp Biochem Physiol 72C 65 74 Meylan W M and Howard PH 1995 Atom Fragment Contribution Methods for Estimating Octanol Water Partition Coefficients J Pharm Sci 84 83 Niemela J R 1993 QTOXIN program ver 2 0 Danish Environmental Protection Agency Niemi G J Basak S C Veith G D Grunwald G Environ
598. dance Document for Aquatic Effects Assessment OECD Paris F Pedersen H Tyle J R Niemel B Guttmann L Lander and A Wedebrand 1995 Environmental Hazard Classification Data Collection and Interpretation Guide for Substances to be Evaluated for Classification as Dangerous for the Environment 2nd Edition TemaNord 1995 581 Nordic Council of Ministers Copenhagen January US EPA 1999 Development of Chemical Categories in the HPV Challenge Program http www epa gov HPV pubs general categuid htm US EPA 2000a The Use of Structure Activity Relationships SAR in the High Production Volume Chemicals Challenge Program http www epa gov hpv pubs general sarfinll htm US EPA 2000b ECOSAR http www epa gov oppt newchems tools 21lecosar htm US EPA EC 1993 US EPA Joint Project on the Evaluation of Quantitative Structure Activity Relationships Commission of European Communities Final Report July G D Veith R L Lipnick and C L Russom 1989 The toxicity of acetylenic alcohols to the fathead minnow Pimephales promelas Narcosis and proelectrophile activation Xenobiotica 19 5 555 565 5 Brown D S and Allison J D 1987 MINTEQA1 Equilibrium Metal Speciation Model A user s manual Athens Georgia USEPA Environmental Research Laboratory Office of Research and Development OECD 1998 Harmonized Integrated Hazard Classification System for Human Health and Env
599. ee i n HPLC Kov HOF ae REMUS M ee ee HPLC log K 0 OECD 117 1989 E 4 20 Cis Pil
600. elas BODs COD20 5 28 10 1 E a TRAY EY 5 iy 50 LAD HEM E b 0 1 day 7 A9 4 3 3 2 28 OAI
601. g A9 7 5 2 2 L E Cs0 100mg l 10 A9 7 5 2 3 4 A9 7 5 2 4 A9 7 5 2 4 1 7 7
602. ge on respiration and toxicant uptake by rainbow trout Salmo gairdneri Richardson Physiol Zool 64 145 168 Bodor N Huang M J 1992 J Pharm Sci 81 272 281 Broto P Moreau G Vandycke C 1984 Eur J Med Chem 19 71 78 Chiou T 1985 Partition coefficients of organic compounds in lipid water systems and correlations with fish bioconcentration factors Environ Sci Technol 19 57 62 CLOGP 1995 Daylight Chemical Information Systems Inf Sys Inc Irvine Ca CSTEE 1999 DG XXIV Scientific Committee for Toxicity and Ecotoxicity and the Environment Opinion on revised proposal for a list of Priority substances in the context of the water framework directive COMMs Procedure prepared by the Frauenhofer Institute Germany Final report opinion adopted at the 11 CSTEE plenary meeting on 28 of September 1999 Comotto R M Kimerle R A Swisher R D 1979 Bioconcentration and metabolism of linear alkylbenzenesulfonate by Daphnids and Fathead minnows L L Marking R A Kimerle Eds Aquatic Toxicology ASTM 1979 vol ASTM STP 667 Connell D W Hawker D W 1988 Use of polynomial expressions to describe the bioconcentration of hydrophobic chemicals by fish Ecotoxicol Environ Saf 16 242 257 Connell D W 1990 Bioaccumulation of xenobiotic compounds Florida CRC Press Inc pp 1 213 De Bruijn J Busser F Seinen W amp Hermens J 1989 Determination of octanol water partition coefficients with the slow st
603. id acute toxicity test 850 1035 Mysid acute toxicity test 850 1045 Penaeid acute toxicity test LEFOY E2000 E9 AVEO EOCH YO BLU GT BIL ORM amp SVVLEOABOHBNIE CC EHKI LEFT ELER b BS 537 850 1045 Penaeid acute toxicity test 850 1075 Fish acute toxicity test freshwater and marine 850 1075 Fish acute toxicity test freshwater and marine 850 1300 Daphnid chronic toxicity test 850 1300 Daphnid chronic toxicity test 850 1350 Mysid chronic toxicity test 850 1350 Mysid chronic toxicity test 850 1400 Fish early life stage toxicity test 850 1400 Fish early life stage toxicity test 850 1500 Fish life cycle toxicity 850 1500 Fish life cycle toxicity 850 1730 Fish BCF 850 1730 Fish BCF 850 4400 Aquatic plant toxicity test using Lemna spp Tiers I and II 850 4400 Aquatic plant toxicity test using Lemna spp Tiers I and II 850 4450 Aquatic plants field study Tier III 850 4450 Aquatic plants field study Tier III 850 5400 Algal toxicity Tiers I and II 850 5400 Algal toxicity Tiers I and II 3 ASTM E 1196 92 ASTM E 1279 89 95 Standard test method for biodegradation by a shake flask die away method ASTM E 1625 94 Standard test method for determining biodegradability of organic chemicals in semi continuous activated sludge SCAS EC C 4 A to F Determination of ready degradability Directive 67 548 EEC Annex V 1992 EC C
604. inen W and Hermens J 1989 Determination of octanol water partition coefficients for hydrophobic organic chemicals with the slow stirring method Environ Toxicol Chem 8 499 512 ECETOC 1998 QSARs in the Assessment of the Environmental Fate and Effects of Chemicals Technical report No 74 Hansch C and A Leo 1995 Exploring QSAR American Chemical Society Hilal S H L A Carreira and S W Karickhoff 1994 Quantitative Treatments of Solute solvent Interactions Theoretical and Computational Chemistry Vol 1 291 353 Elsevier Science Howard P H Boethling R S Stiteler W M Meylan W M Hueber A E Beaumen J A and Larosche M E 1992 Predictive model for aerobic biodegradation developed from a file of evaluated biodegradation data Envir Toxicol Chem 11 593 603 Howard P And Meylan W M 1992 Biodegradation Probability Program Version 3 Syracuse Research Corp NY Langenberg J H Peijnenburg W J G M and Rorije E 1996 On the usefulness and reliability of existing QSARs for risk assessment and priority setting SAR QSAR Environ Res 5 1 16 R L Lipnick 1986 Charles Ernest Overton Narcosis studies and a contribution to general pharmacology Trends Pharmacol Sci 7 161 164 R L Lipnick 1989a Hans Horst Meyer and the lipoid theory of narcosis Trends Pharmacol Sci 10 7 July 265 269 Erratum 11 1 Jan 1990 p 44 R L Lipnick 1989b Narcosis electrophile and
605. ironmental Effects of Chemical Substances Document ENV JM MONO 2001 6 OECD 2000 Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures OECD 2001 Guidance Document on Transformation Dissolution of Metals and Metals Compounds in Aqueous Media Santore R C and Driscoll C T 1995 The CHESS Model for Calculating Chemical Equilibria in Soils and Solutions Chemical Equilibrium and Reaction Models The Soil Society of America American Society of Agronomy Santore R C and Di Toro D M et al 1999 A biotic ligand model of the acute toxicity of metals II Application to fish and daphnia exposure to copper Environ Tox Chem Submitted Skeaff J Delbeke K Van Assche F and Conard B 2000 A critical surface are concept for acute hazard classification of relatively insoluble metal containing powders in aquatic environments Environ Tox Chem 19 1681 1691 Tipping E 1994 WHAM A computer equilibrium model and computer code for waters sediments and soils incorporating discrete site electrostatic model of ion binding by humic substances Computers and Geoscience 20 6 073 1023 547 548 10 550 A10 1 FRX A10 1 1 10
606. irring method Environ Toxicol Chem 8 499 512 Devillers J Bintein S Domine D 1996 Comparison of BCF models based on log P Chemosphere 33 6 1047 1065 DoE 1996 Guidance on the aquatic toxicity testing of difficult substance Unites Kingdom Department of the Environment London Doucette W J Andren A W 1987 Correlation of octanol water partition coefficients and total molecular surface area for highly hydrophobic aromatic compounds Environ Sci Technol 21 pages 821 824 Doucette W J Andren A W 1988 Estimation of octanol water partition coefficients evaluation of six methods for highly hydrophobic aromatic compounds Chemosphere 17 pages 345 359 Driscoll S K McElroy A E 1996 Bioaccumulation and metabolism of benzo a pyrene in three species of polychaete worms Environ Toxicol Chem 15 8 1401 1410 ECETOC 1995 The role of bioaccumulation in environmental risk assessment The aquatic environment and related food webs Brussels Belgium ECEOOC 1996 Aquatic toxicity testing of sparingly soluble volatile and unstable substances ECETOC Monograph No 26 ECETOC Brussels European Commission 1996 Technical Guidance Document in support of Commission Directive 93 96 EEC on Risk Assessment for new notified substances and Commission Regulation EC No 1488 94 on Risk Assessment for Existing Substances Brussels Ghose A K Prottchet A Crippen G M 1988 J Computational Chem 9 80 90 Gobas F A
607. ke flask test with surface water and short term rate measurement in activated sludge In Hales S G ed Biodegradation Kinetics Generation and use of data for regulatory decision making From the SETAC Europe Workshop Port Sunlight September 1996 pp 101 115 SETAC Europe Brussels Nyholm N amp L Torang 1999 Report of 1998 1999 Ring test Shalke flask batch test with surface water or surface water sediment suspensions ISO CD 14592 1 Water Quality Evaluation of the aerobic biodegradability of organic compounds at low concentrations ISO TC 147 SC5 WG4 Biodegradability OECD 1993 Structure Activity Relationships for Biodegradation OECD Environment Monographs No 68 Paris 1998 OECD 1994 US EPA EC Joint Project on the Evaluation of Quantitative Structure Activity Relationships OECD Environment Monograph No 88 Paris OECD 1995 Detailed Review Paper on Biodegradability Testing OECD Environmental Monograph No 98 Paris OECD 1997 Guidance document on direct phototransformation of chemical in water OECD GD 97 21 Paris OECD 1998 Harmonized integrated hazard classification system for human health and environmental effects of chemical substances Paris Document ENV JM MONO 2001 6 Pedersen F H Tyle J R Niemela B Guttmann L Lander amp A Wedebrand 1995 Environmental Hazard Classification data collection and interpretation guide for substances to be evaluated for classification as danger
608. luding labels and safety data sheets It aims at ensuring that information on physical hazards and toxicity from chemicals be available in order to enhance the protection of human health and the environment during the handling transport and use of these chemicals The GHS also provides a basis for harmonization of rules and regulations on chemicals at national regional and worldwide level an important factor also for trade facilitation While governments regional institutions and international organizations are the primary audiences for the GHS it also contains sufficient context and guidance for those in industry who will ultimately be implementing the requirements which have been adopted Adopted in December 2002 by the Committee of Experts on the Transport of Dangerous Goods and the Globally Harmonized System of Classification and Labelling of Chemicals the GHS is regularly updated revised and improved as experience is gained in its implementation The Plan of Implementation of the World Summit on Sustainable Development WSSD adopted in Johannesburg in 2002 encourages countries to implement the GHS as soon as possible This fourth revised edition of the GHS contains various new and revised provisions concerning inter alia new hazard categories for chemically unstable gases and non flammable aerosols further rationalization of precautionary statements and further clarification of some of the criteria to avoid differences in their interpre
609. ous for the environment Nordic Council of Ministers 2nd edition TemaNord 1995 581 166 pp Schwarzenbach R P P M Gschwend amp D M Imboden 1993 Environmental organic chemistry 1st ed John Wiley amp Sons Inc New York Scow K M 1982 Rate of biodegradation In Lyman WJ W F Reehl amp D H Rosenblatt 1982 Handbook of Chemical Property Estimation Methods Environmental Behaviour of Organic Compounds American Chemical Society Washington DC ISBN 0 8412 1761 0 Chapter 9 Struijs J amp R van den Berg 1995 Standardized biodegradability tests Extrapolation to aerobic environments Wat Res 29 1 255 262 Syracuse Research Corporation Biodegradation Probability Program BIOWIN Syracuse N Y http esc syrres com esc1 biodeg htm Westermann P B K Ahring amp R A Mah 1989 Temperature compensation in Methanosarcina barkeri by modulation of hydrogen and acetate affinity Applied and Environmental Microbiology 55 5 1262 1266 542 3 Anliker R Moser P Poppinger D 1988 Bioaccumulation of dyestuffs and organic pigments in fish Relationships to hydrophobicity and steric factors Chem 17 8 1631 1644 Bintein S Devillers J and Karcher W 1993 Nonlinear dependence of fish bioconcentration on 7 octanol water partition coefficient SAR and QSAR in Environmental Research Vol 1 pp 29 39 Black M C Millsap D S McCarthy J F 1991 Effects of acute temperature chan
610. proelectrophile toxicity mechanisms Application of SAR and QSAR Environ Toxicol Chem 8 1 12 R L Lipnick 1990 Narcosis Fundamental and Baseline Toxicity Mechanism for Nonelectrolyte Organic Chemicals In W Karcher and J Devillers eds Practical Applications of Quantitative Structure Activity Relationships QSAR in Environmental Chemistry and Toxicology Kluwer Academic Publishers Dordrecht The Netherlands pp 129 144 R L Lipnick ed 1991a Charles Ernest Overton Studies of Narcosis and a Contribution to General Pharmacology Chapman and Hall London and Wood Library Museum of Anesthesiology R L Lipnick 1991b Outliers their origin and use in the classification of molecular mechanisms of toxicity Sez Tot Environ 109 110 131 153 R L Lipnick 1995 Structure Activity Relationships In Fundamentals of Aquatic Toxicology 2nd edition G R Rand ed Taylor amp Francis London 609 655 546 Loonen H Lindgren F Hansen B Karcher W Niemela J Hiromatsu K Takatsuki M Peijnenburg W Rorije E and Struijs J 1999 Prediction of biodegradability from chemical structure modeling of ready biodegradation test data Environ Toxicol Chem 18 1763 1768 Meylan W M and P H Howard 1995 J Pharm Sci 84 83 92 OECD 1993 Structure Activity Relationships for Biodegradation OECD Environment Monograph No 68 OECD Paris France OECD 1995 Environment Monographs No 92 Gui
611. ry 1997 LISEC Staff Final report transformation dissolution of metals and sparingly soluble metal compounds in aqueous media cadmium LISEC no WE 14 002 January 1998 LISEC Staff Final report transformation dissolution of metals and sparingly soluble metal compounds in aqueous media cadmium oxide LISEC no WE 14 002 January 1998 OECD Guideline for testing of chemicals Paris 1984 Guideline 201 Alga Growth Inhibition test OECD Guideline for testing of chemicals Paris 1984 Guideline 202 Daphnia sp Acute immobilisation test and Reproduction Test OECD Guideline for testing of chemicals Paris 1992 Guideline 203 Fish Acute Toxicity Test OECD Guideline for testing of chemicals Paris 1992 Guideline 204 Fish Prolonged Toxicity Test 14 Day study OECD Guideline for testing of chemicals Paris 1992 Guideline 210 Fish Early Life Stage Toxicity Test International standard ISO 6341 1989 E Determination of the inhibition of the mobility of Daphnia magna Straus Cladocera Crustacea LISEC Craenevenne 140 3600 Genk Belgium CANMET Natural Resources Canada 555 Booth St Ottawa Canada K1A0G1 561 562 GHS 1992
612. s June 18 19 1996 European Chemicals Bureau Meeting on Testing Methods for Metals and Metal Compounds Ispra February 17 18 1997 OECD Metals Working Group Meeting Paris October 14 15 1997 LISEC Staff Final report transformation dissolution of metals and sparingly soluble metal compounds in aqueous media zinc LISEC no BO 015 1997 J M Skeaff and D Paktunc Development of a Protocol for Measuring the Rate and Extent of Transformations of Metals and Sparingly Soluble Metal Compounds in Aqueous Media Phase I Task 1 Study of Agitation Method Final Report January 1997 Mining and Mineral Sciences Laboratories Division Report 97 004 CR Contract No 51545 Jim Skeaff and Pierrette King Development of a Protocol For Measuring the Rate and Extent of Transformations of Metals and Sparingly Soluble Metal Compounds in Aqueous Media Phase I Tasks 3 and 4 Study of pH and of Particle Size Surface Area Final Report December 1997 Mining and Mineral Sciences Laboratories Division Report 97 071 CR Contract No 51590 Jim Skeaff and Pierrette King Development of Data on the Reaction Kinetics of Nickel Metal and Nickel Oxide in Aqueous Media for Hazard Identification Final Report January 1998 Mining and Mineral Sciences Laboratories Division Report 97 089 CR Contract No 51605 LISEC Staff Final report transformation dissolution of metals and sparingly soluble metal compounds in aqueous media zinc oxide LISEC no BO 016 Janua
613. sessment for new notified substances and the Commission Regulation EC No 1488 94 on risk assessment for existing substances European Commission Ispra 541 ECETOC 1998 QSARs in the Assessment of the Environmental Fate and Effects of Chemicals Technical report No 74 Brussels June 1998 Federle T W S D Gasior amp B A Nuck 1997 Extrapolating mineralisation rates from the ready CO2 screening test to activated sludge river water and soil Environmental Toxicology and Chemistry 16 127 134 Langenberg J H W J G M Peijnenburg amp E Rorije 1996 On the usefulness and reliability of existing QSBRs for risk assessment and priority setting SAR and QSAR in Environmental Research 5 1 16 Loonen H F Lindgren B Hansen amp W Karcher 1996 Prediction of biodegradability from chemical structure In Peijnenburg W J G M amp J Damborsky eds Biodegradability Prediction Kluwer Academic Publishers MITI 1992 Biodegradation and bioaccumulation data on existing data based on the CSCL Japan Japan chemical industry Ecology toxicology amp information center ISBN 4 89074 101 1 Niemela J 2000 Personal communication to OECD Environment Directorate 20 March 2000 Nyholm N U T Berg amp F Ingerslev 1996 Activated sludge biodegradability simulation test Danish EPA Environmental Report No 337 Nyholm N amp F Ingerslev 1997 Kinetic biodegradation tests with low test substance concentrations Sha
614. tation
615. the statistical analysis of ecotoxicity data A guidance to application OECD Environmental Health and Safety Publications Series Testing and Assessment N 54 Pedersen F H Tyle J R Niemeldi B Guttmann L Lander and A Wedebrand 1995 Environmental Hazard Classification data collection and interpretation guide TemaNord 1995 581 US EPA 1996 Ecological Effects Test Guidelines OPPTS 850 1000 Special Considerations for Conducting Aquatic Laboratory Studies Public Draft EPA 712 C 96 113 United States Environmental Protection Agency http www epa gov opptsfrs home testmeth htm OECD Monograph 11 Detailed Review Paper on Aquatic Toxicity Testing for Industrial Chemicals and Pesticides Rand Gary M Fundamentals of Aquatic toxicology Effects Environmental Fate and Risk Assessment 2 Boesten J J T I amp AM A van der Linden 1991 Modeling the influence of sorption and transformation on pesticide leaching and persistence J Environ Qual 20 425 435 Boethling R S PH Howard J A Beauman amp M E Larosche 1995 Factors for intermedia extrapolation in biodegradability assessment Chemosphere 30 4 741 752 de Henau H 1993 Biodegradation In P Calow Handbook of Ecotoxicology vol I Blackwell Scientific Publications London Chapter 18 pp 355 377 EC 1996 Technical guidance documents in support of the Commission Directive 93 67 EEC on risk as
616. v 4 A9 4 2 4 9 STP OECD 303 STP A9 4 2 4 10 pea oe

Download Pdf Manuals

Related Search

Related Contents

KZS-P KZS-PG  Samsung NP370R5V Felhasználói kézikönyv (ingyenes DOS)  Swingline Standard Staples 1/4"  LevelOne KVM-0290 KVM switch  Presentation User Manual  listado de equipos requeridos lic pub #001_2015  

Copyright © All rights reserved. Failed to retrieve file