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1. 2 1 2 HIV HBV HCV
2. a ng 3 1 2 3 1 2 121 C 20
3. 90 7 8 9 10 11 12 E TOSOH II CE A E TOSOH II CEA E TOSOH II SUB II E TOSOH II E TOSOH II CEA HAMA Human Anti mouse Antibody
4. 4 5 2 2 1 BIA IEMA CEA CEA B F 4
5. CEA 002 Calibrator Lnt 2000105702080D00 Rate 60 50 oT 1 1 2 3 2 BE TOSOH II CEA CEA 230 30 CEA 2SD 5 8 ng mL 1 2 SI CEA ng mL SI gL ugCEA L ng CEA mL x 1 0
6. 4 CEA 2 8 C 20 C 15 25 C 2 3 B TOSOH II CE A 4 390 mg dL 17 mg dL 18 mg dL 1 600 mg dL 2 5 g dL 20 mg dL
7. 1 E TOSOH II CE A CEA CEA 2 B TOSOH II CE A E TOSOH II CEA 1 E TOSOH II CEA 2 3 B TOSOH IE CE A 4 E TOSOH TII SUB II 1 E TOSOH II 4 2 B TOSOH II 5 E TOSOH II 6 BEB TOSOH I CBA 1 10 2 CEA 1 REIA IEMA 3 CEA CEA
8. 37 C 10 3 B TF 4 363 nm 447 nm 5 CEA 90 6 100 ng mL 1 5 AIA 1800
9. CEA Carcinoembryonic Antigen 1965 Gold P Freedman S O0 50 70 18 20 7 3 700 1 4 6 6 S S CEA CEA 1 1 2 2 E TOSOH II CEA 1 PU Rate 8 mmo L s E TOSOH II CBA 1 BE TOSOH II CEA 2 FU
10. CEA 100 NCA 0 01 AFP 0 01 6 y EIA x y 0 967 x 0 059 r 1 000 n 50 y x Y 1 005x 0 049 r 0 983 n 99 1 1 2 3 5 6 90
11. 72 15 25 C 1 8 2 8 C 9 2 8 C 90 3 E TOSOH II CEA 1 2 2 8 C 1 E TOSOH II CEA WHO CEA WHO 1st IRP 73 601 E TOSOH II 1 E TOSOH II 1 100 mL 15 25 C 3 2 8 C 30 5
12. 2 8 C 12 TOSOH TI CEA 100 0025254 I 0015354 E TOSOH II CE A 1 2 1 0 mL x2 E TOSOH II CEA 0015968 0015955 E 0015956 E TOSOH E TOSOH II E TOSOH II E TOSOH II TOSOH I 100mL x2 100 mL x2 Gold P and Freedman S O Demonstration of tumor specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques J Exp Med 121 439 462 1965 Gold P and Freedman S O Specific carcinoembryonic antigens of the human digestive system J Exp Med 121 467 481 1965 Banjo C Shuster J and Gold P Intermolecular heterogeneity of the carcinoembryonic antigen Cancer Res 34 2114 2121 19724 Oikawa S Nakazato H and Kosaki G Primary structure of human carcinoernbryonic antigen CEA deduced from cDNA sequerce Biochem Biophys Res Commun 142 511 518 1987 Paxton R
13. CEA FU 0 5 5 0 nmol L s ng mL FU FU A B C A 2 FU B 1 FU C 2 CEA nmol L s nmol L 5 ng mL CEA 2 80 ng mL 100 20 CEA E TOSOH II CEA 3 CEA 2 80 ng mL 2 10 15 4 0 5 100 ng mL 0 5 ng mL 1 2 1 FU y 2 x SD 10 20 000 ng mL 5
14. 100 U mL 5 EDTA 6 2 8 15 25 C 2 4 1 E TOSOH II CE A 15 25 C 240 1 15 25 C 8 2 lt 8C 16 30 2 8C 30 E TOSOH IT CEA 15 25 C
15. 1 1 1000671001 101D 2011 10 4 2009 6 3 20100EFZZ00112000 1 E TOSOH I CEA EIA CEA 1 2 3 4 HBs HIV HCV 5
16. BE TOSOH II 1 2 5 L 15 25 C 30 6 E TOSOH I 1 5L 15 25 C 30 2 1 2 3 1 E TOSOH II CEA 2 50 L 100
17. Mooser G Pande H Lee T D and Shively J E Seduence analysis of carcinoembryonic antgen Tdentification of glycosylation sites and homology with the immunogloblin supergene family Proc Natl Acad Sci USA 84 920 924 1987 Zimmermann W Ortieb B Friedrich R and von Kleist S Isolation and characterization of cDNA clones encoding the human carcimoembryonic antigen reveal a highly conserved repeating structure Proc Natl Acad Sci USA 84 2960 2964 1987 Carcinoembryonic antigen 60 637 643 1987 Yamashita K fotani K Kuroki M Matsuoka Y Ueda lI and Kobata A Structural studies of the carbohydrate moieties of carcinoembryonic antigens Cancer Res 47 3451 3459 1987 252 1123 2743 1 O120 17 1200 TEL 0467 76 5384 FAX 0467 79 2550 TosoH 3 8 2 TEL 03 5427 5181 FAX 03 5427 5220 TosoH 2
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