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1. SR2. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved
3. 2013 6 19
4. Novosom AG pH CD240 Calando Pharma Inc IT 101 Calando Cyclocert TM
5. DACHPt 1 1
6. SR Inc SR tnc 3 31 12 03 5834 8787 http www sharedresearch jp Email info sharedresearch jp Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved
7. 1967 Bristol Myers Squibb Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14
8. Medius Associates 2001 0 59 1 5 10 II 8 1596 III 10 2096 2096 sSh ared lesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 SW Strengths Weaknesses 30
9. 1978 FDA Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 DNA
10. Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 PEG
11. 2015 3 2015 3 12 389 400 1 1 284 499 989 600 494 989 600 4 Sh aredd Mesearch http www sharedresearch jpD Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 DDS siRNA
12. 2015 3 389 0 979 500 495 DDS siRNA 2013 5 Regulus Therapeutics Inc microRNA RNA RNA
13. 100nm EPR Enhanced Permeation and Retention Effect Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights
14. Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 2013 3 1 4403 63 579 30 79 43 303 20 9 37 436 18 0 23 250 11 2
15. 2 J 0 sh ared Kesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 94 92 457 1 SR Research Report 2015 5 14
16. 2 DNA DNA 1983 DNA 1
17. 2009250393 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 2013 10 2013 10 21 2013 10 7 1 268 900 1 268 900 1 268 900 1 257 460 2013 10 11 2013 10 7
18. 2014 5 DDS Sh ared Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457
19. NC 6004
20. 2014 4 2014 4 2 2014 3 sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 2014 3 471 466 1 126 1 174 1 104 1 176 1 122 1 198 1 30 67 32 75 NC 6004 NC 6300 pH Orient Europharma Co Ltd
21. I 1 b IT MD NC 4016 I MD Anderson NC 6300
22. QOL Quality of Life NC 6004 NC 6004 2006 5 1
23. NC 6004 NC 4016 ADCM siRNA 211 224
24. 1 II III IV T TI I I III TV
25. 2 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1
26. Orient Europharma CO Ltd OEP NC 6004 OEP 2012 11 OEP OEP NC 6004 OEP OEP OEP
27. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 NanoBiotix X NanoBiotix
28. MG VOYAGE GROUP SBS KLab
29. sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 1 110 1 118
30. 3 000nm 300nm 100nm 100nm
31. CEO 1996 6 1997 8 1 4403 2001 1 TLO 2002 6 1 4272 a Sh ared GYcsea ch http www sharedresearch jp Copyright C Shared Res
32. 2009 5 25 TLO siRNA siRNA NanoFect 2013 6 siRNA
33. 200980118842 4 2008 525801 2013 5 30 NC 4016 IND NC 4016 1 5 29 FDA Food and Drug Administration 1 MD Phase
34. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 2014 6 3 siRNA NanoFect
35. 2015 2 24 DDS siRNA siRNA active NanoFect siRNA
36. Hydration NC 6004 NC 6004 7 NC 6004 OEP 2014 2 2014 11
37. http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 1996 6 CEO iPS COO Chief Operating Officer 2008 6 2007 12 2008 5 MG
38. 1 nm 10 1 DDS Drug Delivery System 20 100
39. NC 6004 Orient Europharma Co Ltd 1 1 b MD
40. 2K 180nm 1800nm 4000nm 7300nm 8000nm a 20 100nm i TD rm Sh ared lesearch lp http Www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved ET 457 1 SR Research Report 2015 5 14 O
41. Bristol Myers Squibb EL Dach DNA DNA CHOP
42. 2013 12 5 2013 529476 Sh aredd Mesearch http www sharedresearch jpD Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 NanoFect 1 B B 30 50nm
43. NC 6004 I II OEP II 2013 6 NC 6004 I II TFDA Taiwan Food and Drug Administration 1 II Hydration
44. ADCM Antibody Drug Conjugated Micelle siRNA NanoFect 2013 6 2012 7 2013 10 2013 9
45. Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 2015 3 19
46. OEP NC 6004 NC 6004 OP Nano OP Nano GMP Good Manufacturing Practice OP Nano OP Nano gt Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 NT 1 000 2016 12
47. I b I 1 I I NC 4016 I 1 I NC 6300 K 912
48. Active NanoFect siRNA sSh ared 1 ch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 SR NC 6004 NC 4016 NC 6004 NC 4016 II
49. J P Morgan Securities plc 2013 10 28 2013 10 30 8 400 Shared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 PE 1 7 700 700 J P Morgan Securities plc
50. Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 68 92 SR Research Report 4 6 Phase 2 Phase I NC 6300 i 27 NE105 26 1 30 Anti body Drug Conjugate Micelles ADCM
51. RNAi siRNA RNA RNAi PTGS SIRNA RNA RNA RNA RNA RNA siRNA 1999 Science RNA mRNA 1 RNA mRNA RNA mRNA RNA RNA RNAi RNA 20 RNA tRNA RNA rRNA Sh aredd Mesearch http
52. 1 2012 10 1 b IT Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 MD NC 4016 I 2013 12 MD NC 6300 I 2013 9
53. 2013 6 24 NC 6004 IND NC 6004 6 21 FDA Food and Drug Administration Sh aredd Mesearch http www sharedresearch jpD Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 MD II 2 2013 6 20 1 4063
54. 2011 9 NC 6300 2012 3 1 4523 2012 3 1 700 2 025
55. 0 FDA FDA 2006 0 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 IND Investigational New Drug PFS Progression Free Survival
56. ADCM Antibody Drug Conjugated Micelle 10
57. J GCA DIC TOKAT
58. 2013 10 8 651 11 418 9 069 24 270 727 Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 2013 3 2013 5 13 2013 3 Orient Europharma Co Ltd 373 7 99 526 2012 3 333 432
59. Active NanoFect gt Active NanoFect gt 30 gt 75 siRNA http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 2015 2 1 4519 siRNA active NanoFect siRNA
60. 16 2015 3 2015 3 330 2014 3 471 1 955 1 126 1 929 1 104 1 970 1 122 1 53 85 30 67 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 2014 3 2014 3
61. 1 10 1 1 1 000 000 000 1 100 Pt DNA q PEG
62. 2014 6 2 2 1 E 7974 I Sh ared lesearch http www sharedresearch jpD Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 SiRNA siRNA small interfering RNA RNA mRNA RNA RNA siRNA
63. ADCM 2015 1 2015 1 29 pH pH pH
64. 2012 3 2 4 1 2011 9 290 07 3 08 3 09 3 10 3 11 3 12 3 13 3 14 3 103 263 354 118 84 346 374 472 676 4 1 154 0 34 6 66 7 28 4 310 7 7 9 26 3 43 1 92 68 247 71 51 125 273 182 212 12 194 106 47 33 221 101 290 464 11 3 74 0 30 1 39 8 39 4 63 9 27 0 61 4 68 7 729 647 638 540 553 555 628
65. E7974 1 E7974 ADCM 10 E7974
66. 6 300 JP J P Morgan Securities plc 2013 11 22 2013 11 25 2013 9 30 364 352 33 600 397 952 6 300 404 252 JP
67. DDS GMP Good Manufacturing Practice International Conference on Harmonization ICH Abraxis Bioscience Inc DDS In Vitro Sh aredd Mesear
68. 1 4063 2013 10 7 33 600 5 600 28 000 2013 10 21 2013 10 23 0 90 1 00 P
69. 2014 3 2013 9 17 OEP OP Nano NC 6004 Orient Europharma Co Ltd OEP OEP OP Nano 1 NT 29 500 000 NC 6004 OEP 2012 11 OP Nano
70. NC 4016 1 II NC 6300 2011 9 2013 1 siRNA siRNA
71. siRNA AMD siRNA siRNA siRNA 2010 9
72. RNA RNA 20 Alnylam Pharmaceuticals Inc Isis Pharmaceuticals Inc C RNA RNA siRNA 1 RNA 20 25
73. siRNA NanoFect ADCM NanoFect DDS sm 2015 1 2015 3 2
74. Calando PEG Calando siRNA Access Pharmaceuticals Inc NC 4016 DACH Prolindac 2010 II HPMA Supratek Pharma Inc DDS SP1049C 2005 II
75. II 2007 11 II NK105 AUC NK105 I 2010 8 I 2012 7 III II II
76. NC 6004 300 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 3 2017 2018 3 2018 2019 3 OEP II IND I 2012 10 1 20 2014 2015 3
77. 2014 3 51 47 2011 3 2007 3 2011 3 2012 3 1 700 Pe 2014 3 540 2008 3 IPO 2014 3 9 069 2008
78. B 30 50nm siRNA ATP ATP Adenosine Triphosphate 3 ML AL C 10 20nm Active NanoFect Active NanoFect NanoFect ADCM siRNA Active NanoFect
79. 3 3 1 2 NK105
80. NC 6004 Phase I Phase Ib II NC 4016 Phase I ADCM 2015 3 1 599 2014 6
81. 2013 9 24 NC 6004 NC 6004 Orient Europharma Co Ltd OEP Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 OEP 2
82. NC 6300 K912 Improved anti tumor activity of stabilized anthracycline polymeric micelle formulation NC 630 M Harada I Bobe H Saito N Shibata R Tanaka T Hayashi Y Kato Cancer Science 102 1 192 199 2011 NC 6300 2011 9 NC 6300 K912
83. 2014 6 23 1 4523 IE7974 IADCM Antibody Drug Conjugated Micelle E7974 ADCM 10 E7974
84. 2013 10 2014 11 2014 11 11 2015 3
85. 311 326 508 501 149 436 152 437 2 346 NC 6004 5 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 Orient Europharma Co Ltd
86. siRNA 3 2013 6 NanoFect 3 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 A 3 120 140nm
87. 2013 5 1 IND PMDA 1 4523 2012 3 2012 5 10 2012 3 346 310 7 334 2011 3 520 366 2011 3
88. E7974 ADCM siRNA NanoFect ADCM NanoFect DDS Active NanoFect
89. 2014 2 2014 2 12 2014 3 31 1 100 402 632 40 263 200 1 100 2014 1 2014 1 14 NC 6004 NC 6004 http Www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 NC 6004 1 09705599 0
90. NC 6004 2014 7 2014 7 16 pH pH pH 2013 9 1 NC 6300 K 912
91. NK105 380 2 2015 2016 3 NDA New Drug Application NK105 DDS 3 039 2009 1 593 2000 1 780 2018 EvaluatePharma 1 100 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 NC 6004 NC 6004
92. NC 6300 K912 24 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 1 2013 5 NC 6300 K912 IND 2013 9 20 2014 2015 3 2024 2025 3 NC 6300 K912
93. 2012 3 1 4502 2012 4 Sh ared Kesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 90 92 457 1 SR Research Report 2015 5 14 siRNA 2014
94. 2020 2021 3 I 2014 5 1 b T MD 80 2017 2018 3 2020 2021 3 NC 6004 2 272 2007 1 720 2008 905 2003 EvaluatePharma 1
95. NC 4016 NC 4016 NC 4016 2015 4 3 2015 3 2016 3 2015 3 2016 3 2015 3 675 673
96. 84 461 190 462 191 NC 6004 Orient Europharma Co Ltd 1
97. DDS 2015 3 1 2015 3 1 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 57 150 100 2 409 8 9 E 7974 234 7 8 382 277
98. siRNA active NanoFect siRNA 499 2015 3 3 359 444 922 785 40 633 37 635 2 346 3 2014 10 12 594 3 2014 4 12 940
99. 800 OEP OEP OEP OEP 2013 9 OP Nano OP Nano 29 5 2016 12 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 2012 8 31 TFDA Taiwan Food and Drug Administration IDB Industrial Development Bureau Ministry of Economic Affairs
100. AstraZeneca Teva EGFR Roche Genentech Roche HER2 neu Genentech Roche
101. NK105 2002 6 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14_ NK105 1 1 2004 5 2006 4 Drug Delivery System 24 1 2009 NK105 AUC 15 NK105 150mg sq m 210mg sq m 4 1
102. 1 4272 2012 7 ADCM Antibody Drug Conjugated Micelle siRNA ADCM 2014 6 E7974
103. NC 6004 IND Phase 1 Phase llb Ill Phase IIb Phasel Phase Ilb Phase Ilb Phase lI IND Phase EU 2008 3 2014 3 NC 6004 NC 4016 siRNA ADCM 2013 3 238 2014 3 926 2015 3 1 271 2013 10 Shared Gxcscarch http www sharedresearch jp Copyright C
104. 2009208481 2014 6 2014 6 26 NC 6004 3 NC 6004 NC 6004 NC 6004 Orient Europharma Co Ltd OEP Phase OEP OP Nano NC 6004 2016
105. 2014 3 2014 3 18 Antibody Drug Conjugated Micelles Antibody Drug Conjugated Micelles ADCM 2014 3 10
106. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 NC 6300 K 912 1 NC 6300 K 912 pH bpH DDS ADCM Antibody Drug conjugated Micelle 2014 12 2014 12 12 2015 1 1
107. http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 03 3548 0213 1996 6 14 HP httD www nanocarrieLCO D IR IR info nanocarrierCO D Sh ared KWeSGaT ch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved SR Research Report 2015 5 14 277 0882 5 4 19 047 169 6550 2008 3 5 3 IR httDp www nanocarrieLCcO D Ir index html IR 03 3548 0217 4571 SR Research Report SR
108. NC 4016 1 MD Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 NC 6300 I NK105 1 4272 ADCM Antibody Drug Conjugated Micelle
109. E7974 ADCM NanoFect Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 2016 3 16 3 15 3 16 3 j 676 137 43 1 79 7 212 464 60 0 68 796 5 2 232 6 1 108 2 666 2 617 2 772
110. siRNA sm 2015 1 2014 6 1 E7974 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 E7974 ADCM E7974 2015 2
111. pH DDS ADCM Antibody Drug conjugated Micelles pH 2009 7007877 2014 7 14 NC 6004 NC 6004 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14
112. siRNA 3 1mg kg siRNA 3 NanoFect 2013 5 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 2013 5 31
113. C 60 DDS amp CJ Abraxis BioScience Nasdaq ABII DDS 2005 AstraZeneca 2009 3 1 500 2008 3 3 600 NK105 SR DDS
114. MediCelle Debiopharm 2011 3 2005 3 Debiopharm S A NC 4016 2009 3 Debiopharm 1 2011 3 Debiopharm 2012 3 Debiopharm NC 4016 48 28 8m
115. 2006 7 TLO 2007 2 TLO pH 2007 10 Debiopharm S A NC 4016 2007 11 NK105 II 2008 3 2008 4 TLO 2008 9 Orient Europharma Co Ltd NC 6004 Sharedd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved
116. a NK105 a a 10 oo 8 TLO 23 NC 6004 9 2 SM 8 ID TLO 24 6 NC 4016 Ya RT 3
117. lI 8 ee 11 TLO 8 i 11 TLO TLO 7 10 I
118. siRNA ATP 2013 11 2013 11 22 NC 6004 NC 6004 2010 517837 2013 11 18 NC 6004 NC 6004 098118350 2013 11 14
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120. 2 272 2007 EvaluatePharma 1 100 NC 6300 K 912 DNA DNA NC 6300 K912 pH pH
121. 2014 3 130 2013 9 Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 CMO CRO
122. Orient Europharma Co Ltd II Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 2013 2012 10 1 2013 NC 4016 I MD The University of Texas MD Anderson Cancer Center NC 6300
123. PMorgan Securities plc Sh aredd Mesearch http www sharedresearch jpD Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 11 216 8 916 2013 11 2018 10 2 300 2013 11 2018 10 NC 6004 NC 4016 siRNA
124. NC 6004 Orient Europharma Co Ltd 1 I b MD NC 4016 1 MD http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 201
125. ADCM Antibody Drug Conjugated Micelle 2013 9 2013 9 30 2012 7 2013 9 25
126. 2 MediCelle 3 NanoCoat http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 4571 SR Research Report 2015 5 14
127. 2014 3 9 069 2007 3 2014 3 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14
128. 1 2 3 3 1 3 2014 5 NC 6004 NC 4016 2 Sh ared Pb T ch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 38 92 457 1 SR Research Report 2015 5 14
129. 2013 12 2013 12 26 NC 6004 Orient Europharma Co Ltd OEP NC 6004 OEP 2014 1 IND Phase 2013 12 17
130. PCT SR Shared esearch lp http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 2014 3 2015 2012 7 INDA gt 2018 hf 0 2019 Ip mp lL lIPIb I 2020 2014 5 PI a 2020 2012 10 _ P 1 2024 2 PI 2024 NK105 NC 6004
131. ini EE a a a ET 4 CC 3 pH pH 17 TR 5 a 6 14
132. 1980 DDS 2012 3
133. I b HI 1 I IH NC 4016 1 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 1 I NC 6300 K 912 I 1 II E7974 ADCM
134. 1 114 484 NK105 1 4272 2012 7 NC 6004 Orient Europharma Co Ltd OEP
135. SR 137 79 7 2 666 1 108 2 617 171 2 772 207 2 202 109 0 NC 6004 OEP
136. 1 129 1 127 Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 189 285 227 322 1 118 1 120 17 2015 3 3 2014 4 12 939 4 2015 1 3 20 2015 3
137. NC 4016 NC 6300 4 siRNA ADCM NK105 NanoCap NK105 1 4272
138. 2015 3 Sh ared lesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 ADCM Antibody Drug Conjugated Micelle siRNA Active NanoFect NC 6004 Orient Europharma Co Ltd
139. 2015 2 2 Antibody Drug conjugated Micelle Antibody Drug conjugated Micelle ADCM ADCM ADCM ADCM ADC Antibody Drug Conjugate DDS ADCM ADC ADCM
140. ADCM ADCM siRNA Active NanoFect 1 1 2014 5 ADCM Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 Active Targeting 3 WW E7974 2014 6 1 4523 TE7974
141. DNA RNA 1o 5 Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14
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144. siRNA 3 NanoFect NanoFect A 201080038549 X 3 amp sSh ared 1 ch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 15 3 150 176 119 28 57 254 47 317 100 1 675 1430 2 96 4 16 796 83 996 62 096 44 796 60 196 1040 8 42 996 98 125 53 14 27 177 9 251 209 9 14 9 51 1 72 4 41 296 82 996 1747 196 65 2 71 4 44 896 48 996 47 49 69 6 19 2 79 1 375 349 336 352 409 303 423 437 151 8 172 296 114 69 81 9 8 9 13 396 25 8 24 2
145. W 2012 7 2013 10 2013 10 2014 3 37
146. 366 484 398 Orient Europharma Co Ltd 242 NC 6004 1 1 035 237 2012 11 Orient Europharma Co Ltd NC 6004 12 00
147. 919 33 33 2015 3 2016 3 2016 3 2016 3 2 666 92 22 2015 3 1 129 2016 3 2016 3
148. I NK105 1 4272 ADCM Antibody Drug Conjugated Micelle siRNA NanoFect
149. Sh aredd Mesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 NC 6004 NC 4016 NC 6004 III
150. NK105 101 38 2009 3 Debiopharm 229 65 Orient Europharma 119 33 6 2010 3 2010 3 26 2010 3 2010 3 Debiopharm 55 47 14 119 28 2 sSh ared 1 ch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved sSh ared ESEaTCI 4571 SR Research Report 2015 5 14 07 3 08 3 09 3 10 3 11 3 12 3 13 3 14 3
151. 2015 3 1 84 2015 3 2 431 2015 3 2 346 2014 8 2014 8 20 NC 6004 sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 NC 6004 NC 6004 NC 6004
152. 6 300 840 5 460 JP P Morgan Securities plc P 840 P Morgan Securities plc P 5 460
153. DNA pH pH7 pH pH7 pH7 pH7 35 pH RNA DNA DNA 2 RNA 1 RNA mRNA RNA DNA RNA RNA RNAi
154. 20 100nm NanoCap NK105 siRNA ee Medicell NC 6004 2 NC 4016 NC 6300 AA ow N Re NanoCoat I Active Targeting 2014 3 31 http www sharedresearch D Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 i i 21 a 12
155. I 1 I 1 4523 E7974 ADCM Active NanoFect siRNA 2016 3 137
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158. 2012 10 1 b TT MD NC 4016 1 2013 12 MD Anderson NC 6300 I 2013 9 Sh ared hesearch http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 NK105
159. 2010 2003 DDS 1990 DDS DDS DDS QOL http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 DDS
160. SR Research Report 2015 5714 4571 sr_inquiriesQ sharedresearch jp 0 457 1 SR Research Report 2015 5 14 eo 4 4 8 eo 19 Eo 19 oe 24 Mt 32 RE 38 oo 41 0 45 2 2 46 51 RR 53 mE 55
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162. 457 1 SR Research Report 2015 5 14_ 2014 3 2014 5 13 2014 3 OEP 195 103 100 233 130 472 26 3 0 688 926 1 123 2013 3 527 225 211 1 095 432
163. siRNA NanoFect 3 A NanoFect NanoFect 2014 5 2014 5 19
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169. 8 900m lt Huwei Yunlin OP Nano 2015 3 NC 6004 2013 6 2013 6 2013 6 25 NC 6004 NC 6004 Orient Europharma Co Ltd OEP NC 6004 1 II OEP 6 24 TFDA Taiwan Food and Drug Administration
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173. 2014 3 402 652 5 08 http www sharedresearch jp Copyright C Shared Research Inc All Rights Reserved 457 1 SR Research Report 2015 5 14 07 3 08 3 09 3 10 3 11 3 12 3 13 3 14 3 e CF A 663 588 457 452 578 293 635 1 098 1 121 CF B 62 19 4 8 5 1 721 121 7 059 2 562 FCF A B 25 607 461 460 582 2 015 57 8 158 3 683 CF 1 143 643 75 97 1 449 1 924 2 327 9 581 505 A 8 15 16 16 16 18 7 5 19 B 11 14 3 2 4 19 20 27 166 C 6 78 1 29 48 30 41 54 81 FCF A B C 727 571 440 452 590 429 538 1 189 436 SR 2014
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176. 3 2006 3 2013 3 2012 3 2014 3 2007 3 2008 3 3 IPO 2011 3 2012 3 2013 3
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