ホローファイバーカートリッジ オペレーション ガイド
Contents
1. 1 100 ppm tes 10 ppm 30 60 2 3 bonc M E um P um 30 60 med eu J 3 05N 30 60 4 100 200 MERER 5 P 30 60 PEM mau des 1 5 10 ppm 10720 ppm 5 70 Re2. PO Der ID P psig 0 5 10 lt 001 0 002 0 005 0 012 0 013 0 028 1K 1 10 001 0 001 0 003 0 5 10 0 004 0 020 008 0 16 018 O40 0 37 0 95 17 10 17 37 3K 1 10 0 003 0 015 0 04 0 08 0 20 0 22 0 60 EE Em 37 0 5 10 0 009 0 045 0 135 0 35 0 8 0 9 23 3 4 2 0 3 4 7 4 5KK 1 10 0 000 0 02 O08 0 16 0 4 0 5 12 24 2 1 5 0 0 25 10 0 030 0 10 0 35 0 75 2 0 10K 0 5 10 0013 006 020 O45 0 50 iL 1 3 3 0 5 6 3 3 5 6 11 0 25 0 10 0 006 003 0 11 0 25 0 6 0 7 18 32 mE 32 7 6 0 5 10 0 020 009 O30 070 077 16 19 4 6 8 5 5 0 8 5 18 5 30K 10 0 010 0 04 0 16 0 32 0 8 0 9 2 4 4 2 4 2 9 7 0 5 10 0 050 O14 O45 105 116 24 2 9 6 9 12 8 7 5 128 280 50K 10 0015 006 024 O48 0 60 12 4 3 5 6 4 6 4 4 6 0 5 5 0017 007 028 O63 0 70 1 6 15 3 8 6 8 3 8 6 8 4 5 100K 5 0015
3. IX UL ELJ gt H CORE EOS
4. Flux Flux 4 000 8 000 sec1 2 000 4 000 sec
5. c H ULTRAFILTRATION MICROEIETRATION Feed Flow Rate vs AP Water 20 C Maximum 25 C Feed Pressure Maximum d 10 C 45 psig Nominal Nominal Pressure 10 25 C 40 psig TER Housing Size TubulelD FeedFlow Drop psio 25 50 C 35 psig AE mm liters min pP 50 80 C 25 psig Maximum 25 C 150 4 2 T 55 55R 2 300 H5 aximum value at any x point within the 2 150 95 lt 10 C 35 psig 250 8 7 Transmembrane Pressure Feed Pressure k 3 TT i 10 25 C 30 psig 500 30 Pressure minus Permeate 25 50 C 25 psi 0 1 u 25 psig Pressure If Permeate P 9 265 7 4 jJ A 50 80 C 20 psig 2 pressure is not 530 25 1 T measured assume it to 85 e be 0 psig 3 510 9 5 1020 32 5 T 600 8 T 154 2 see above up to 80 C 1000 19 Sanitization 5 to 50 ppm 5 to 50 ppm
6. 5 Flux p 9 Tr ansmembrane Pressure UP inlet Pouted 2 Pbermeate FITI FLUX FLUX 4 oH ALF T 15 25C 75 35 25C 125960730 AIEO IB EADE BELET
7. MF M L jare NL LL 4JI J F1 2 79 j T Valve Ye Pressure Clamp Gauge P Optional tei S S E E 8 E 2 8 BAK 8 E z eo
8. RABE lt EEk 3 A co AH 2 0 05 ppm 25 ppm
9. S US Cu MS queque 70 1 1 100 ppm pH10 11 2 0 1 0 5 N pH13 Page 13 GE UF BAA MP 1 9 UF
10. Flux GE
11. 20C 50C 60 1C
12. e LESTE 2 DE 265 llc u cOSbL ENVZCZI KEF e M E ELA SC 373 GU Ask ds A OD 3 3 7 E Steam in Place SlP amp psz 1 RU IC AKRE C daret Ves 8 3 885 CAIU 6 ca DOORS
13. og TET agr 10 000 NMWC UF 00000 10 000 NMWC 1 2 3psig 5 cun dm ed RUN A NA xU E psig US LA AKO 3 25 psig
14. AO pH 13 pH Sa FSS
15. E3 PexStgnd W 7 5 BE RUP U x68 5 5538 MF f amp TI CAR H J ENZ FLUX ee amp e i TIR ca ces
16. 3 TRAO ELTI 7 t 9 o Nominal Feed Stream Flow Rates Nominal Shear Rate Shear Rate Shear Rate Shear Rate Housing Lumen ID 2000 sec 1 4000 sec 1 8000 sec lt 16000 sec Size mm SEI lliters min lliters min lliters min 0 25 0 05 0 11 0 23 0 4 3 3M 0 5 0 06 0 12 0 25 0 5 3X2 3X2M 0 75 0 1 0 2 0 4 0 8 T 0 15 0 3 0 6 1 2 0 25 0 19 0 38 0 76 1 5 4 4M 0 5 0 3 0 6 1 2 2 4 4X2 4X2M 0 75 0 4 0 8 1 5 3 1 0 6 1 2 2 5 5 0 25 0 65 1 3 2 5 5 5 6 0 5 ta 2 1 4 3 8 6 0 75 1 4 2 8 5 6 11 2 1 2 4 8 16 0 25 1 6 3 2 6 4 12 8 8 9 0 5 ei 5 4 10 6 215 0 75 4 4 8 8 18 35 1 61 12 2 24 5 49 EE 0 25 4 5 9 18 36 SSR 55STM 0 5 6 6 13 2 26 55 55SMO 75 0 75 10 20 40 80 75R 1 1s 30 60 120 0 5 14 28 55 111 45 65 85 0 75 19 39 77 154 1 31 61 122 245 152M154M 0 5 30 60 120 240 1 70 140 280 560
17. cs t TRIS Tcp EE Fd 10155 8 000 sect PA EO UBTELCTBS S S5 Page 20 UFZMFRIETEFIBR n E UAM VAS Feed Stream Flow Rate vs Cartridge Pressure Drop Feed Flow Rate vs AP Water 20 C Feed Flow Rate vs AP Water 20 C Nominal Nominal Pressure Nominal Nominal Pressure Housing Lumen ID Feed Flow Drop Housing Lumen ID Feed Flow Drop Size mm liters min psig Size mm liters min psig 05 0 25 3 3 025 18 3 5M T T 35 35A T 1 3 35ATM 0 5 z 1 2 4 1 355MO 37 535 5 9 3X2 5X2M 0 5 oos 2 1 So I 0 5 A 120 3 5 05 12 3 2 05 26 5 5 4 4M 2 9 6 6 535 10 6 1 2 5 2 0 55 55A 55R 075 40 4 0 5 4 0 55STM 55SMO 80 8 0 4X2 4X2M 0 5 ic 2l 1 eo 22 2 5 dd 120 omi 05 4 5 2 7 05 26 9 1 5 8 6 5 4 75 75R 53 18 3 1 8 1 6 1 60 5 2 16 3 4 120 16 0 5 J a 45 0 5 2 ud 8 6 10 7 TLI 6 6 6 0 75 5 6 4 0 05 55 5 2 112 8 0 65
18. w un TN as El 6 5 CI Page 10 U FAM FEEFEE Cleaning Procedures Alternate Cleaning Procedures Process Foulants in Order of Preference Mammalian Cell Cell Debris A 1 Flush with clean water buffer or saline at 50 C Cu
19. 2 5 NMWC 500 000 NMWC UF pH GE Selection Guide C UF MF Integrity Test Proced U
20. 3 N 3 P A EDIS BLR 3 d GE 8 BARRIA Nominal Molecular Weight Cut off NMWC 3 Rx d 1 000 750 000 NMWC B UP 1 GE J RINDE UP je CU sS LE RIDEN IB d 20328 VEU 3 D 583 Ei J
21. FLUX 200 ml min 02m X006 60 Imh Flux Page 6 U F M FEEFEE 7 25 10C 77 F 20 SF a DARRAITE a Temperature Corrected Flux FluxjT gt x 7
22. GEHHHHH HHHHHHH HHHHHLGEHHHHHHHHHHHHHHHHHHHH GEHHHHHHHHHHHHHHH imagination at work Page 1 lt 2 NAT 3 4 5 e a 7 SAPI VUNU ARIS seen 9 REESE EARS 10 WV eene nnn 14 DES 16 Steam in Place enne nennen 16 nas D a 17 quidein d cede E re PROP eb sie EORR nir eet er EI ep ed CARERE ee 18 dieere Iu D I 19 Page 2 19 OO RP need eto ge de de epa IRR MC 20 AP TEE 21 UF SA 22 Xamplerw TEE 23 ue 24 MaxCellw ProCellw 7J HUVZ7 m 25 2mm 3mm eo 26 27 UFLM F ZUIAZU A387 amp
23. 30 30 MF 1 3 i 7 barg FJR 5psig 0 3 Page 5 x z
24. gt bi Volumetric Concentration System Conversion Relationship Cv y Cv TET y 1 amp 1X Vp 0 096 2X 50 where 5X 80 Cv Volumetric Concentration Factor D Vo Original Feed Volume Vp Volume of Permeate Collected 50X 98 y System Conversion Page 8 UFLMF ETE IRE Mg x A Z3 a jJ L JLC DESMA Jy bl 35385 R fT 7e s 3838 znegm ox EB
25. 13 Micro is available from International Sodium Hydroxide Products Corp Phosphoric Acid PO Box 70 Burlington NJ Nitric Acid 609 386 8770 Citric Acid and Terg A Zyme manufactured by Alconox Inc NY NY 212 532 4040 is available from Lab Supply Houses Tween 80 Polyoxyethylene 20 Sorbitan monooleate are available from Lab and Chemical Supply Houses Sodium Hypochlorite 596 50 0000 ppm NaOCl is Household Bleach Other cleaners available from H B Fuller Company Monarch Division Minneapolis MN 612 781 8071 Page 12 U FAM FEEFEE Cleaning Procedures continued Operation Recommended Protocol Flush A Recirculate clean water or buffer in total recycle for 10 minutes at 8000 to 16000 sec shear rate with 5 psig 0 3 barg outlet pressure Typical solution consumption is 3 to 4 times the system hold up volume Drain solution Clean C Recirculate cleaning solution in total recycle at 4000 to 8000 sec shear rate or 30 to 60 minutes with 5 psig 0 3 barg outlet pressure Typical solution consumption is 3 to 4 times the system hold up volume D Drain solution Rinse E Recirculate clean water or buffer in total recycle for 5 minutes at 8000 to 16000 sec shear rate with 5 p
26. 2 3 Z Microsolute Removal as a function of Diafiltration Volume UF 1 3 95 s
27. Membrane Ar Function of Housing amp Fiber ele tasse doc qu eig ELE Void Volume and Number of Fibers Internal Diameter Fiber 3 Cartridge Internal Nominal Cartridge Membrane Area Nominal Nominal Void Volume Cartridge Housing Diameter Fiber IF Number d Housing Identifier Code mm sq ft sq cm Fibers Lumen ml Shell ml Identifier B 0 25 0 40 370 180 3 Z 3 3M C 0 5 0 15 140 30 2 9 3 3M D 0 75 0 13 120 20 3 8 E Hi 0 12 110 15 8 5 C 0 5 0 31 290 30 5 14 3X2 3X2M D 0 75 0 28 260 20 6 14 3X2 3X2M E 1 0 24 225 15 6 12 B 0 25 1 29 1200 600 10 42 4 4M C 0 5 0 70 650 140 8 45 4 4M D 0 75 0 50 460 75 10 40 E Il 0 45 420 50 12 30 4X2 4X2M C 0 5 48 1 400 140 20 75 4X2 4X2M E il 0 9 850 50 30 50 E VirA Gard EL T VAGAIGUEEEBSVGI NL REA E ARBEN tT Lc CORB OL Cit Selection Guide CERE ESLT SELL Tubing Nipple 1 2 in A D d 1 4 in Tubing Nipple Sanitary Gasket P Sanitary Clamp 3 3X2 m 3M 3X2M CAL 3 8 in 1 Tubing Barb A D 1 2 in LJ Fa Sanitary SP Adaptor from Connector Cartridge End with Sanitary Connection Sanitary to Tubing Barb Connection 3 8 in 1 2 1 1 2
28. D GE UF MF Operating Guide Sipant air diffusion specifications assure cartridge integrity JISPIGSVAEROT S ESE JALE S USA REOT SE Ha EMOU C IPEA EESOD ARE PU Y RCM wPOSEMSMELm EPRE R
29. 887 Uv 7 JUR BSB EX ii 31858 H ERR FRECCE 25C A RAEE 25 E OD3E GO Reagent Acetic Acid lt 5 Acetic Acid gt 5
30. psig ue ZL lt 10 psig Opsig OCODE JE zk X2 FLUX FLUX I 22 H 0 E RISER ES Page 4 U FAM FEEFEE x z UF d ILI TUB MUSIC 2 CAES RMEKET DCU IBAD RA Sig d
31. gt 0 dan 0 020 40 60 80 90 95 98 99 Percent of Solute Removed E c Hose A Pressure Clamp z Gauge Optional 8 2 1 9 ER E E 2 z S 3 2 4 E S 5 Diafiltrate Reservoir
32. 1 d XC 2 0 1N ROS 3 3 100ppm 4 30 250 1 5 1 2 100 ppm NTE RE REBRE FALLT o d zz 3 33 30 60 30 50C
33. Concentration Cv gb ey ASME Z AS nu S Sa i ES EGG 8 0038 9 Flux c HG OB EX NS 30cm 3 4 5 35 45 Flux Flux ges eco Fu AURI 8000 sec 6
34. O 2 MaqxCell MaxCell 1 5 2 in Sanitary Connector 2 Adaptor Clamp o C Da Te t a o O ring O E 3 8 1 1 2 in Sanitary Connector MaxCell cartridges can easily retrofit competitive 5 inch diameter cartridges 2 in Sanitary ProCell Cartridge Connector 2 a v es deing with SS Housing V V Locking 152M 154M Nut 1 t 5 E 9 o ProCell 1 1 2 in E EA l Sanitary 6 JLO DIS Congector 300 ft 28 m 0 5 mm MaxCell Cartridge 45 65 85 Membrane Area as a Function of Housing amp Fiber Internal Diameter Void Volume and Number of Fibers Fiber
35. dj X3513871058 B9 57 10 a POS cimi 3 40 High flux lt E8738 E 1 IEL TRY 3 1 I
36. PB Bn GE 5 3 E SOP f E GMP GE
37. 5psig 10 1 50C NaOCl amp 100 ppm C 9H 9 uu NqOCl 1 NMWC UF 2 3 4 9 UZE 9 2 ELO ek LES NNMWCS30 000 ED J CHIPE d zc Ex VERI Flux 1655 CO Cesta ig EOM ET IE TE LAVSILCBIK I SB FEOOUIPELE So BEIAK LEDNI DIREIA lt jp4 QU LV LZ mm qnt ga 1 100 1
38. Cleaning shortterm 20 gt up to 300 ppm up to 300 ppm d 30 minutes 50 C VA a Eas Neb ur cum 100 ppm 100 ppm T 20 C pH Range 2 to 13 2 to 13 Membrane Area as a Function of Housing amp Tubule Internal Diameter Void Volume and Number of Tubules Tubule A Cartridge Internal Nominal Cartridge Membrane Area Nominal Nominal Void Volume Cartridge Housing Diameter Tubule ID Number of Housing Identifier Code mm sq ft sq ml Tubules Lumen ml Shell ml Identifier AX2TC H 2 0 6 0 05 15 35 70 4X2TC K 5 0 4 0 04 8 40 65 6 H 2 2 4 0 22 65 125 140 6 K 3 1 8 0 17 33 145 120 9 H 2 5 0 46 150 325 500 9 K 5 4 7 0 43 90 415 360 10 H 2 10 2 0 95 150 600 785 10 K 3 9 1 0 85 90 700 625 55 55R H 2 14 1 3 390 900 1 050 55 55R K 5 10 6 1 205 1 020 850 75 75R H 2 27 2 5 390 1 465 1 810 75 75R K 3 2 2 205 1 670 1 510 85 H 2 60 5 6 760 3 300 4 500 85 K 5 45 4 2 400 3 400 3 600 154M H 2 112 10 4 1 500 5 950 7 350 154M Page 26 U F M FEEFEE GE
39. AR Ts 850 EUN JEX su IPTE 5 RERET TE HINRSC orem TERCEROS n DECOR TAAT A Cretentote IURE a E AEEIPICT EU as ERUR BONTERBLERD PARIY aeS p zu ZUR Ten 2 UF
40. e Y FLUX LM AUOD REAE T VE DIII OU T IB ERU SSECUD OM J BDZI WILL CED CI Recommended Autoclave Procedure Steps as Depicted in Graphs on Page 15 Starting Pressure 14 7 psia Starting Temperature Ambient Room Temperature Cumulative End of Step End of Step Step Time Pressure Temperature Comments minutes psia C Slow Warm up il 0 0 7 2 6 2 7 3 9 1 2 4 14 5 4 7 5 15 5 2 7 6 21 5 10 5 7 22 5 4 7 8 28 5 14 7 9 31 10 5 10 37 25 11 45 14 7 Residual Air Reduction and Temperature Equalization T2 50 33 7 13 58 14 7 14 65 33 7 15 72 14 7 Ramp up and Dwell at Autoclave Temperature 16 79 33 7 17 119 33 7 Gradual Cool down 18 132 14 7 19 150 5 7 20 s 00 Pull vacuum over 6 min in 5 in Hg increments ntroduce steam over several minutes Pull vacuum over 3 minutes ntroduce steam over 5 5 minutes Pull vacuum over
41. Flux Imz 1 L Imh 1 ftz 1 o chi ENE ND sio Tis d 5 C ERIRE NC R 50 Imh psi gfd 1m2 1psig 1 50 L 25 Imh psi Permeate Flow ml min Flux Imh x 0 06 Cartridge Area m Er b S4 J GC c 8 ON D SUM 8 UFP 10 c sA 0 2 mO 200 mL min Flux 60 Imh
42. MA BM g J 32 0838 XR 6E FR ba 2 9 o p d S ENDJE 40 7 450 11 12 1 50
43. IRIB UP etu ua EU T WF uu ulus n e d lt f 30 JST IRA Vv VS pet 4 30 GE MF 5 NMWC500 000 UF 5psigbA P CR UELEU 38383 24 cst ec
44. 1
45. Feed ON Permeate Reservoir Page 9 o 5b z j pups vcr RES qa Jed 9 m kx J GE t 73 873 02 E BS ODISSE ER COUPER DIC V NIB 87i IASAD EE NS GE ARR IRIS
46. Cartridge Internal Nominal Cartridge Membrane Area Nominal Nominal Void Volume Cartridge Housing Diameter Fiber IF Number of Housing Identifier Code mm sq ft sq cm Fibers Lumen ml Shell ml Identifier C 0 5 37 3 5 6 700 620 1 250 45 D 0 75 28 5 2 65 3 700 645 1 400 45 E A 2 2 5 2 600 800 675 45MSM E 1 25 25 2 400 750 500 45MSM 65 C 0 5 66 6 1 6 700 1 000 2 200 65 E T 47 4 4 2 600 1 280 1 170 65MSM C 0 5 60 5 6 6 000 950 2 000 65MSM E 1 45 4 2 2 400 1 200 875 85 C 0 5 140 13 6 700 1 900 4 550 85 E il 9 9 2 600 2 470 2 440 152M C 0 5 140 13 14 600 2 200 3 300 152M E 1 102 9 5 5 825 2 900 950 C 0 5 300 28 14 600 4 200 7 000 154M 154M E 1l 215 20 5 825 5 500 2 000 Page 25 n 2mm 3mm GE 2mm 3mm UF NMWC 30000 100 000 500 000 3 0 1um MF 2 mm
47. 8 Page 27 MidGee 9 00 17 30 TEL 03 5331 9336 GE aws T 169 0073 uli GE imagination at work 3 25 1 lritertek pU TEL 03 5331 9336 FAX 03 5331 9370 Bie e mail Tech JP ge com
48. BJ Olpu 35 2 4 24 1 6 O25 18 1 2 12 0 8 0 45p 12 0 8 8 0 5 065p SU dd Page 22 U F M FEEFEE Xqmpler GE Xampler
49. Tubing Nipple 4 4X2 4M 4X2M Page 23 dep oue Umen Shu Membrane Area as a Function of Housing amp Fiber s Void Volume and Number of Fibers Internal Diameter Fiber Cartridge Internal Nominal Cartridge Membrane Area Nominal Nominal Void Voume Cartridge Housing Diameter Fiber IF Number of Housing Identifier Code mm sq ft sq cm Fibers Lumen ml Shell ml Identifier B 0 25 4 3 750 2 000 35 100 5 C 05 2 1 2 000 520 35 100 5 D 0 75 I7 1 600 300 40 85 E H 1 3 1 200 170 40 65 C 0 5 5 2 4 800 520 75 210 6 D 0 75 4 3 700 270 75 200 6 E 1 3 2 800 170 85 140 B 0 25 9 7 9 000 5 000 110 320 8 G 0 5 5 7 5 300 1 300 120
50. Validated Autoclave Cycles Housing MF UF _ MES oh Size 9A GE Size 35A 5 5 3t 521 F 2L 7 3 amp 4 GEO CRESU IC ES SO UR SIEHE C 9 REO UT Snc GE Size 45A 3 10 Sze65A Page 15 Steam in Place GE INA TITVACIa Z Steam in gp Place 3 3 SAME RIDA 182253187 Uv 276 z Steam in Place C M BUERT o
51. F MF R EE ure Guide UF MF Cartridge Validation Information U Midje F MF UM F F As Guides QuixStand exStand V T73 Fr sembly amp Operating SV ZEN S GE ZO AMAHUAATMAXUNNUXIICBILAERE EE BAS UE Seen MEI S SEX CERIS Do FET SIO STLOBSIEUEGEOINUI LN RE NTI AS 5081 RIED E CODEC 9 REA DAIS EDET L SLUT IUE L CBIES SCEA TC EN Emof seos CA Ces Page 16 G EFM rr U FM
52. Flux d Pressure Page 7 JU d EZAR inia ve PEERS SCIL C BOURBTGEISURIOS FLUX 2 8 77277 RBODTERDEE SUE T S 20 FLUX
53. Reservoir gt WE 2 Permeate Reservoir 10L LX FOUE QuixStand W ACH 1 200u R Bro US BEJT 5 3 4 28 GE 7 A CEL SHNIAET USP24 KELI LT S PEED EIEL 6 OE SEC REIMAA CI GE VL TAA UH LAXE Integrity Test Procedure Guide K ELE JIB amp c Validation Information Bookl et La Gik 2 ELEDARE SERE h amp f72C Page 3
54. UF Pi P21
55. Acetic Anhydride Acetone Acetonitrile lt 10 Aliphatic Esters Amines Ammonium Chloride 1 Polysulfone Membrane Cartridge Chemical Compatibility Usage Acceptable Short Term Only Not Recommended Not Recommended Short Term Only Not Recommended Not Recommended Acceptable Reagent Hydrogen Peroxide lt 1 Usage Short Term Only Isopropyl Acetate Not Recommended Isopropyl Alcohol lt 10 Acceptable Kerosene Lactic Acid lt 5 Acceptable Mercaptoethanol lt 0 1M Acceptable Methyl Alcohol lt 10 Acceptable Methylene Chloride Ammonium Hydroxide lt 5 Benzene Butanol lt 1 Butyl Acetone Butyl Cellosolve Calcium Chloride Chloroform Citric Acid lt 1 Cyclohexanone Dichlorobenzene Diethanolamine lt 5 Dimethyl Acetamide Dimethylformamide Dimethyl Sulfoxide Acceptable Not Recommended Acceptable Not Recommended Not Recommended Acceptable Not Recommended Acceptable Not Recommended Not Recommended Acceptable Not Recommended Not Recommended Not Recommended Methyl Ethyl Ketone N Methyl Pyrolidone Nitric Acid lt 1 Nitrobenzene Oleic Acid lt 5 Oxalic Acid x 196 Not Recommended Not Recommended Not Recommended Short Term Only Not Recommended Short Term Only Acceptable Phenols lt 196 Acceptable Phosphoric Acid lt 0 1N Short Te
56. MF A CFP 2 E 3A UFP 100 E 55A a UF 5 TD 5ESSU FROUTAUCK ICSU b c d
57. amp c Fa GE JUAZ P DERE i a 8 UF MF d FIRE e rt ent D VADAK
58. 250 8 D 0 75 4 4 4 100 750 120 270 E i 3 9 3 600 520 145 140 C 0 5 12 5 11 500 1 300 225 550 9 D 0 75 10 9 300 750 225 590 9 E d 9 8 400 520 275 15 B 0 25 29 27 000 14 000 350 620 35 35A 35 35A 35STM C 0 5 14 5 13 500 3300 350 480 35STM 35SMO D 0 75 10 8 10 000 925 375 525 35SMO E 1 9 9 9 200 1250 285 385 55 55A C 0 5 35 32 500 3300 600 1150 55 55A SR B 0 75 27 25 000 1925 600 1230 SR 55STM 55STM 55SMO E 1 23 21 000 1250 730 660 55SMO 75 75R C 0 5 65 60 000 3300 935 2325 75 75R E 1 40 37 000 1250 1170 1165 1 1 2 in Sanitary Connector 1 1 2 in R Endfitting Sanitary 1 2 in Connector Connector Tubing Nipple 5 6 1 1 2 in Sanitary 1 1 2 in 1 1 2 in Connector Sanitary Sanitary Connector Connector eL 55R 75R 35 55 75 Tubing Nipple 8 9 Page 24 U F M FEEFEE MaxCellrm ProCellW MaxCellw ProCellw 0 5 mm MaxCell 140ft 13 m2 MaxCell
59. 5 to 50 ppm 5 to 50 ppm Cleaning shortterm 30 minutes 50 C up to 100 ppm up to 300 ppm Maximum Continuous 20 C 100 ppm 100 ppm pH Range 2 to 13 2 to 13 Autoclavable Versions See notes on accompanying pages for condition and number of cycles Models with A as a suffix Models with A as a suffix 3s COE RASENE GE N 100 ppm Tt 9 Fil Clorox973 7 3 596 50 000 ppm NaOCl NaOCI ppm 250 1 psig x 0 06895 barg Page 19 n E UAM VAS iid JLA T ERI E9 Tu Jo RAE L
60. 65MSM dE 10 5 1 8 1 1 122 3 0 6 6 5 245 9 0 05 10 6 5 0 05 55 10 21 10 85 db 20 9 075 18 3 7 1 122 5 7 55 7 6 245 17 1 24 5 2 9 05 120 5 7 49 6 0 152M 240 UES 1 280 3 560 9 05 120 11 AP iun i 240 22 1 280 5 7 AP 560 17 20C Page 21 ZZ MLZKCES E RORII SP ZK E EPFL ES ESKCOD EL XI C 9 TAAGZKIC ER S SRL ADS DR 05 5 fei 10 000 NMWC UF UF
61. hour 5 Flush with clean water Substitute 0 296 Terg A ZymeO at 50 XC pH 9 10 for NaOH Dairy Protein insoluble A 1 Flush with clean water Calcium Complexes 2 Circulate HsPO at 50 C pH 3 5 4 for 20 minutes 3 Flush with clean water 4 Circulate 0 5N NaOH at 50 C for 20 minutes 5 Flush with clean water 6 Circulate NaOCI at 50 C pH 10 11 for 1 hour Monitor and maintain chlorine level 7 Flush with clean water Water Treatment Iron Complexes A 1 Flush with clean water 2 Circulate Citric Acid at 50 C pH 2 2 5 for 1 hour 3 Flush with clean water Optional if low water flux 4 Circulate a low foaming alkaline cleaner for 20 min 5 Flush with clean water Mineral Scale A 1 Flush with clean water 2 Circulate HNO at 50 C pH 4 for 1 hour 3 Flush with clean water Optional 4 Repeat Step 2 and leave a soaking overnight 5 Flush with clean water Substitute HsPO4 50 pH 4 for HNOs Edible Oils Oil Grease Colloids A 1 Flush with clean water 2 Circulate 0 296 Micro at 50 C pH 9 10 for 1 hour 3 Flush with clean water Optional 4 If iron fouling is suspected wash with Citric Acid pH 2 2 5 as noted above B Substitute alternate detergent cleaners for Micro Increase detergent concentration NgOC 19 NaOCl
62. 004 O14 0 28 0 36 07 0 8 zI 3 7 ss 3 7 8 5 0 5 5 0 020 010 037 079 O87 2 0 i7 4 7 8 4 4 7 8 4 7 6 300K 5 0 010 005 O21 O42 0 54 10 2 3 0 5 5 5 5 28 0 5 5 oaz oi oz I oi 1 0 2 2 23 6 1 11 4 6 6 11 6 247 500K 5 0 020 008 022 053 0 68 16 7 4 0 7 0 m 8 3 7 0 18 0 38 0 750K 1 5 0 023 008 025 0 59 075 y 19 44 78 9 2 8 9 Transmembrane P P 2 1 25C 9 oaa CERI 2 3 1 5 GE 1 Minimum MF Bubble Point psig barg 50 50 10096 i EtOH H20 IPA
63. 1 minute ntroduce steam over 6 minutes Pull vacuum over 1 minute Be certain that autoclave temperature does not drift above 124 C ntroduce steam over 6 minutes Pull vacuum over 2 5 minutes ntroduce steam over 6 minutes Pull vacuum over 6 minutes ntroduce steam over 7 minutes Pull vacuum over 8 minutes ntroduce steam over 7 minutes Pull vacuum over 7 minutes ntroduce steam over 7 minutes Dwell for up to 40 minutes op steam introduction open bleed valve Slow cool down with vacuum Cool cartridge completely before integrity testing at least 3 hours preferably overnight Page 14 UFAMFETIERFIBE vate preme Temperature C 0 20 40 60 80 100 120 140 160 Time minutes Temperature as a Function of Time for GE Healthcare Biosciences Recommended Autoclave Cycle See step by step description in table on page 14 Pressure psia O0 20 40 60 80 100 120 140 160 Time minutes Pressure as a Function of Time for GE Healthcare Biosciences Recommended Autoclave Cycle
64. 5 where T1 Reference temperature e g 77 F T2 Actual temperature F 18 C 64 4 F 40 JU TARI Imh ml o TSF 40 Imh x 644F 47 8 Imh ESRB 7 E OSEE C Flux Temperature TMP TMP TMP TMP JU COS 0 Tis x53 DMA Flux Flux
65. 50 C pH 5 8 1 hr 3 Flush with clean water Blood amp Serum Proteins A 1 Flush with clean water buffer or saline at 50 C Products Enzymes Lipoproteins Lipids 2 Circulate 0 5N NaOH at 50 C 1 hr Vaccines Protein 3 Flush with clean water Products Optional 4 Circulate NaOCI at 50 C pH 10 11 1 hr 5 Flush with clean water B 1 Flush with clean water buffer or saline at 50 C 2 Circulate 0 196 Tween 800 at 50 C pH 5 8 1 hr 3 Flush with clean water C 1 Flush with clean water buffer or saline at 50 C 2 Circulate 0 296 Terg A ZymeO at 50 C pH 9 10 1 hr 3 Flush with clean water NqOC 19 NaOCI SipgR arce Is 13 Page 11 Cleaning Procedures continued Process Foulants Alternate Cleaning Procedures Juice and Beverage Proteins Pectin A 1 Flush with clean water Clarification Colloids Tannins 2 Circulate 0 5N NaOH at 50 C for 1 hour Polyphenolics 3 Flush with clean water Optional 4 Circulate NaOCI at 50 C pH 10 11 for 1
66. F f jo Ad uexXp e1oq nd S1U3UJUJO zW D9JV 9UDJdUUSN 9ZIS 9J0d TCPE x gs Por er 7M10 Ce amp PIDE TS COSE amp amp xOSOne 2 cx ICL W Mu uw 0 J 91DeulJad Www J919UJDI U9UUT lapo 95DpJ1JD 133HS 901 VIVO 1531 1VIN MId d d ren uay 9UJTIOA 9UJTIOA uonplDId 129 9Jn1DJgduJa1 sis O SCORE EU OCC S HH peu euin oA pag UJDaJ1S peeJ Page 17 GE 7 C3 FrEr fx Dac GE DE eJ 1
67. OT Sc l YLIN TAOX EEDD ASIA PU CREE NCIDES Page 18 UFZMFfIETEFIBR n I ODF BIGU SIE Ice 2 C3 PAUA Jo FRATI pH PRERA Maximum ULTRAFILTRATION MICROFILTRATION Maximum 25 C 0 1 u 30 psig 0 2 u 25 psig 0 45 u 15 psig 0 65 u 15 psig Maximum value at any point within the cartridge Maximum Transmembrane Pressure Feed Pressure minus Permeate Pressure If permeate pressure is not measured assume it to be 0 psig 10 C 75 psig 10 25 C 65 psig 25 50 C 50 psig 50 80 C 50 psig 1K 30K 10 C 60 psi 10 25 C 50 psi 25 50 C 45 psi 50 80 C 35 psi Q Q Q Q 100K 750K lt 10 C 50 psig 10 25 C 45 psig 25 50 C 35 psig 50 80 C 25 psig Maximum 25 C 0 1 u 20 psig 0 2 u 15 psig 0 45 u 10 psig 0 65 u 10 psig 0 1 u up to 80 C 0 2 u up to 80 C emperature see above 0 45 p up to 50 C 0 65 u up to 50 C orine Sanitization
68. U d DE oj CI RDK 380387 ges Exp UF MF BS CDI 13 GRI UF ZA IE jus s 10 000 TMP 1 000 NMWC 3 000 NMWC 15 psig 5 0007 30 000 NMWC 10 psig
69. lture 2 Circulate NqOC at 50 C pH 10 11 1 hr 3 Flush with clean water B 1 Flush with clean water buffer or saline at 50 C 2 Circulate 0 5N NaOH at 50 C 1 hr 3 Flush with clean water C 1 Flush with clean water buffer or saline at 50 C 2 Circulate 0 296 Terg A ZymeO at 50 C pH 9 10 1 hr 3 Flush with clean water Bacterial Cell Whole Proteins Cell Debris A 1 Flush with clean water buffer or saline at 50 C Broths Polysaccharides 2 Circulate 0 5N NaOH at 50 C 1 hr Lipids Antifoams 3 Flush with clean water Optional 4 Circulate NaOCI at 50 C pH 10 11 1 hr 5 Flush with clean water B 1 Flush with clean water buffer or saline at 50 C 2 Circulate 0 296 Terg A ZymeO at 50 C pH 9 10 1 hr 3 Flush with clean water C 1 Flush with clean water buffer or saline at 50 C 2 Circulate 0 596 Henkel P3 11 at 50 C pH 7 8 1 hr 3 Flush with clean water Bacterial Cell Proteins Cell Debris A 1 Flush with clean water buffer or saline at 50 C Lysates 2 Circulate 0 5N NaOH at 50 C 1 hr 3 Flush with clean water Optional 4 Circulate H3PO at 50 C pH 4 1 hr 5 Flush with clean water B 1 Flush with clean water buffer or saline at 50 C 2 Circulate NaOCI at 50 C pH 10 11 1 hr 3 Flush with clean water Optional 4 Circulate HsPO at 50 C pH 4 1 hr 5 Flush with clean water C 1 Flush with clean water buffer or saline at 50 C 2 Circulate 0 196 Tween 800 at
70. rm Only Sodium Azide x 196 Acceptable Sodium Chloride Acceptable Sodium Dodecy Sulfate lt 0 196 Acceptable Sodium Hydroxide x 1N Acceptable Sodium Hypochlorite lt 300 ppm Acceptable Sodium Hypochlorite gt 300 ppm Short Term Only re GA Disodium Salt of EDTA x 1096 Acceptable Sodium Nitrate 196 Acceptable Ethanol x 1096 Acceptable Sulfuric Acid x 196 Acceptable Ethyl Acetate Terg A Zyme x 196 Acceptable Formaldehyde lt 196 Acceptable Toluene Not Recommended Formic Acid lt 1 Acceptable Tris Buffer pH 8 2 1M Acceptable Furfura Triton X 100 lt 200 ppm Acceptable Glutaldehyde x 0 596 Acceptable Urea x 4M Acceptable Glycerine lt 2 Acceptable Xylene NotRecommended Recommended Guanidine HCI 6M Acceptable Chemical noted as Short Term Only are typically Hydrochloric Acid 0 01N Acceptable acceptable for membrane cleaning EAM EIC Cla dU EVER OO 7 V 3 WC A 1 T DU S 100 MidGeew JO Operating Guide H
71. sig 0 5 barg outlet pressure Typical solution consumption is 2 times the system hold up volume F Drain solution G Repeat rinse water recirculation drain steps E amp F two more times H Rinse both retentate and permeate sides with clean water buffer controlling the permeate rate at 0 1 liters minute sq ft of membrane area The retentate flow rate should be nominally 5 1096 of the permeate flow rate l tis preferred that the cartridge be oriented vertically and permeate be removed from the upper permeate port J Continue to rinse for 60 minutes Note 60 minutes is a nominal time frame To conserve woter buffer time may be reduced to 30 minutes 20 2
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