化学物質のリスク評価のためのガイドブック＜実践編
Contents
1. 1 DE li 3 0000000000 120000000 00000000000 44 00000000000 45 00000000000000 5 6 0000000 0620 5 1 000000000 54 000000000 000000000 1000000 11000000 200000000 200000000 330000000 3 00000 0000 PNECIT SR 400000 Y 2 4 ll ll LL DO Li j jJ Ll Li ji j2. NPE1 5 48 O 0 11 mg L Hall etal 198911 O O O Z SER 000 ai 1 E Les UU U Selanarm m i ESE KOEL Ta pra Dora gt al 15323 EUR A gez iE AE si al 1959 k ir i ul 11 Preufakachneriella suhcap rara E 14 gt ET T 0 9 1 2 1 4 4800 0 11mg L NPE 5 96 D 0 NOEC 8mg L 000 __ mn 96 0 1 0mg L NPEo 10 oo 62 117122 0 8 8 GE 2 00000000000 2 j Ll Li Li Li LJ i Li Li LI J Li LI Li Li Li Li i NPEs 4800 0 1 00000 000000000 3 OFA 0000000000000 00 1140000002 00000000000 000000 DO ji Li J Li Li ji
3. NOAEL gag J 0 UD D 000000000000 00 1 20 0000 0000000000 080000 000 44000000 O 1900 0000000000 7000000000000000 NOAEL 13 00000000000 00000 101 1 001 Li Ll LJ LJ Li LJ J Li J 1 9 000 00 LI 00 LI Li Li Li 10 Median Lethal 1000000 100040000 _ 000000 1000000 900000001 Median Lethal Dose 100000 01000 00000001 Lowest Observed 0000000000000000 OAEL adverse ae U U U 1000000 0000 Observed 00000000000060000 90 NOAEL Aavere Gate 1111 j U No Observed Effect ARI i ll Bi Ji li li 4 12 0000000000 Tolerable Daily goog Intake 70600000 00000NOAELO 0 Ti
4. i i B N n 001 0 0 1 10100101 0 0 DEE TEN DN O DD 00 0 110101 R aii 1 000000000000000000000 EL B R N 2 RR REN BE NEB DEN BERR DOBa J 00 Li 0 00000 0000000000000 4 300000000 0 00000000000 01010101 0000000 0000 TD DUO 1 HAN HEN H BEH REB H B HAE METN 0000000000 10000 17100000000000000000000000000000 UU Pollutant Release and Transfer Register 0000000000000 00000 0 11 10000000 Ll Li Li Li i LI LI LI i LI Li LI LI Li Li LI i Li Li 00 0000000 5 90 1 0015 010101101010 5900 sekna men 0 2 0000000 590 0 150900000 DL
5. 0 0 0 0 04 10100110 0 1 OOO 1 4 0000000000000 20000000000 00000 e a e ey 00 0000000000000000000000000 15000000 ll j DE j 000 0009000009100 ll j j j j DO j j i i 0090000009100 Ll Li Li Li Li ji j
6. ll lJ j j J j j 0 0 ji LJ Ll J Li Li LJ Li j ji Cs mg L L 0000 90 Qs 00000 Mp 1 000 0000 0000000000000000000 60kgg0000000000000000000 of 0000000000000 9 90 U 000 31 536 000 10 g kg 60 kg 31 536 000 10 g kg 1 9 10 2 g 2 0000 95 00000000 16 16 al JOD O 0 sea _ fete 188 TI 4 00000000 65 3 Cs 0000000 0 00000 95 00000000000 Cs L 000000 05 1 9x 1073 9 0 7 03 2 7x 10 4 mg L 2 7x 10
7. DABA j j j J 00900000100 201 02001001 Ll Ll J j J j j Ll J LJ 0000000000600 00888 10000000 B 2 NA ENE 0000 0000 UUU 2000000000000000000 0000000 DABA j 00000 900000100 n ENE ll j J j DO DB OOOO Li i Ll Ll Li LJ LJ J J li Li DOBa LI Li i jJ ji ji j j DO j METI LIS O O O Ll Li Li LJ ji ji U J J J 1 0000000000 ll ll j j j j j j LL Li Li jJ ji 0000000000 0000000000000000000000000000
8. L WO 000000000 0000000000000000000000000000000000000 0 0 0000000000000000000000000000000 00000000000000000 0000000000000 5140 ll j 1 j j DO 101 1101 Li i ji jJ Li Li 000 CEUD 000000 9 0000000000 4 1 80 Ll Ll Ll LJ LI 1000000000000 LJ 0000000000000 0 140000 DABA pg j j O j Ll J 0 000100 DOBa J J J Do Li
9. UUDUUUUUUD eda a E J BARA BIRA B B B BR 69 ooo 9 0 00000 00 140 30 13000000000000 000 00000 http www prtr nite go jp prtr calc html 2002 0000 00000000000000 2010 0 OU 160 10 0 30 0 http www prtr info jp prtr index html 0 40 00000 0 10 O 40 0000 2002 0000 00 0 0 0 0 000 0 0 0 0 0 0 0 0 0 0000000 00 180 1997 00000 0 0 000 00 0 0 0 0 0 00 0 0 0 000 0 000000 2005 55000 140 00000000 11111111 DD 2006 I U DI OO U 2006 2007 Journal of Occupational Health 48 290 306 0 400000 0000000000 NEDO40 000 0000000 CERDO 07 0000000000 NITE 2007 p000000000 0 0 0 00 ver 2 http www safe
10. OECD 000000000 000 200300 0 B B N B B BEEN H H HUB B HERR B iti J T B B BIR 2 76201 0000060 ed B B BAN HUR BEN Ha H E 168202 0000 000000 E I H B R HIN 00000000000 00000 00000000000 000000000000 16203 16210000000 m 000000050 PROA B H li MEN BA DK HUB B B N B R BI U ET I ORG E NE B R H N h H E B m HD DH BD 00000 0 00000000 SEF li BE ji
11. 00000000 00000000000 ll Ll Ll Ll DI j LJ LJ Ll J i Li j ji 00 00000000000000000000000000000 00000610000 j J J Ll LJ i ji ji li 1 100 0 00000000 00000000000 00000 000000 000 0000000000 000000000000000000000000000000000 000000000000 010100 0000000000000000060 0000 0000000000 00000 ll j j j 0 UB D D 00 200000000000 00 DDD Li Li Ll Li LJ J i i J 01000100010010101101
12. 2003 17 Li Li 000 3 6m ll j 1 E U j j J J J J i J J jJ Li 00000000000000000000000000 2006 56 1 3 5 000 0 0 00 00 00 00 0 0000 501 000 0 10101000 0000000 1 2000 000000 000000 3650010 800 900 170 00 00000 000000 20030000000000000000 TERR E THAN HERE FS 240 iN GE CAF HA HHA EN 1 7 00000 00000000 Y 2 110010 Li J J i Ll Ll LJ Li Li 00 5 0 0 0 0 m s 0 0 3 2m s 00 200001m s o00000 0 1 1 3 Li Ll 0100 0 J 000000000 0000100 2003 5 3 0 00000 00 0000 140000000 11 4 4 000000000000000 0 15 000000 4 000000000 58 0000000000 ki 00004 2000000000001 00000000 30000000000000
13. UDDOD0D000000000000000000 00000000000 00000 0000000000 0000000000000000000000000000000000000 0 1 4 30 B H R NA N D D B D Dn L 000000 000000 gooo U 0000 B N PRA H B H H BAR B BAB H N TN R HER VE PE OR RER 4 HEN 41 4 000000 0000 000 E E bi 0 0 0 0000 00000 4 DOBODO DO DD ODO 0 0 0 00 0 0 0 0 0 0000000000000 0000 NA N PE NER 0000 n NEB N B N HUB NR li B L B
14. 3 000000000000000000000000000000000 PNEC Predicted No Effect Concentration 0000000 UFs PNEC NOEC UFs 4 0000 000 3 PNEC 02010 101 00 0000 PNEC mg L 2900000 NOEG L 000000000 6 P TL B TITLE P li PURA B N E NE H 4
15. e HEB BVE E 42 00 HIHI LH H Ll i J J j J J LJ j J Li HI Li HH Li 0 0 DABA j j j j j 1111 j 0 00000010000 E EO 0 00 84 J HAD DZ EL 01 D
16. 16 Li Ll J MSDS 0000 7 UUUUUUUUUUU Ll Ll LJ J Li Li ji j 8 UUUUUUD Ll Ll LJ J Li Li ji j 9 Li Li li 10 00000050 Ll Li li Li UUUUUUD 11 UUUUUUD 12 000000 00000000000000000000000 5 0 0000000000000 GHSU ID http www meti go jp policy chemical management law msds msds62 html 21 11000000 LDso 3 500mg kg 27 29 08mg L 4 4 350mg kg gt 0000 LDso 4 300mg kg 39 00 5 LDso LDso UUUUUUUUUUD IHH N NH l 000000000000000000 moderate 00000000 gt 0 00 24 2 I LI DJ DI ACGIH gt 0 A40IARC 000 30000000000000000 O OL ee E 7 DH 00 o o g n ri H ay HE zul 05 n H Ou a EZE ee a O Qu oO O DD Os m ao Ou r F l Coa gg Ogum DH j i JI DI D DII DI DI A DH ad E a ad ELE DI DD D I DI DI
17. HQ 0000000 0 00000 00000 00 0 15 3 0 08 mg m 1 9 00000 190010000000 M000000000000 00000 ll i Li J J DO LJ Li jJ jJ li ll l1 j jJ j 30000000000000000000000 2000000000 Ll j Ll j 1 i 20111110 j 0 06mgm D Ii 0000000000000000 00 750 1000000 500000000000 20000000000000000 ll j 0 j j j J J 0 Li ll j J j j 0 Li J J Li Li ji ji ji 59 00000060 1040000 00000 000000000000000 lt
18. 00000000000 m 00000000000000000000 000 NPEs 6 100 0000 NPEs 0000 3 2x 107 250 0000 0000 00 000 0 00 00 000 00000 Ll Li Li li TH 00010 61 00002 1 00000000 1700 18 23 24 000000000000000000000000 0000000000000000000000000 0000000 0 00000000000000 510 DU 2000912000000 00000000 0000000000 00 2 2 09 1 2 9 1 2 91 00003 00000000000000 000 Dom et al 19990 000000000 00000000000 et al 1989 etal 1979 D000 7 00 0 48 LCs
19. LOL 6 511 le rsa 000000 Im 150 mE 24 0 0 1 71 0 i gvary et al 1980 00 x 900 x LO04A000 x 0000 UUUD 10 x x 2111 10 1 5 500 MEN LI S 00 _ 1 1 5 m 60 ES Hi DID E DI END 000 00001 000000 0000000000 000000000 0 0000000000000 0000000000000000000000000 X 001000 00000000000 000 LI L1 Li ji ji OU A 60kg 0O Li Li j li UUUUUUUD
20. e DOBO DO DL Ll Ll Li Li ji e e 1 11101 e 1 Li 01 Li ji ji li 41 ll j j DO j J 0000 20000000000 0000 000000000000 000000000 0 0 00 0 0 ll j j 1 0 OOO ODO 0 Li i ji j YU l aaa aa 410000 0000000000000000000 000000000000000000000 DO OO j j j 1 00 J Ll J 00 J Ll Ll 11000 UU0000000 2 2 HE
21. 0101000101001 0 00 0 00 0 000 100000000 00 0000000000000 2400000000000 ji 01 LJ J i LJ Li Li J LJ LJ LJ LJ Li 000000 mg m 0 000 0 mg m5xg 000 24 00 x0000 7 0 0 1080000 000000000000000000000 188 mgm 000000 2007 000000 000000 0 188 x 8 24 5 7 0 44 8 28 10 lI Il lI Il Ll LI LI LI LI LI LI LI LI LI LI L Li Li Li DODODO 11110101 28000000 1 0 1 1 101011 1 1 28 3 0000 ga a a la rc a O 1 ES UUUUUUUDUD Maximiza Test Buehler 00 29 H N i H HH DT EEE KEL ji zu DD J DD DD Di OG Ey ET ETTI ET EDE ENE EES a UI HH aad a a J RD 1 30 2 ll J Ll Ll J 0000000000000 NOAEL LOAEL
22. 000000000000000000000000000000 900000000 000 0000000000000 0000000000000000000000000 11100101 0000 000000000 S UZ 11 1 HL HL LI oO i i J Li 0000000000 1 1 aa 2 0 000000000000000000000 2 0000 UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU 1 HHHH BB BL BD BL LL 000000000 0000000000000 ll j j j j j J j Ll i Ll 0090000009100 ll j j j j 100 0 Li J Li ji ji j e e 11 DD DO 0 Li Ll Li Li i ji Li e e 00000090 2
23. F 000000000000000000000000000000 11100000000 0 LOAEL NOAEL 1 00000000000000000 Ver 2 0 NEDOD NITE 2007 GF 10101101 DO BBB J J Ll LJ J Ll Li LJ LJ J Ll Li Li Li 3000000 10000UUUUUUUUD 000000 NEDO 2005 1 11000000000000000000000000000000000000 0000000 UFs 00000 000000 UFs 000 x 2000 x SLOAEL 0 III x 80000 00000 Uncertainty Factor Hl LJ LJ LI 1 J J J 1 LJ J J J J II LJ 11101 1 LI U HII L Assessment Factor O O U O Safety Factor 00000000 1000000000000 31 Ll Ll J LJ 00 Li LOAEL Ll LJ i J Ll J Ll ji ji Li 00000 10 x 10 x 10 x 5 5000 3
24. 1 5000000000000000 Y 1 12 010 LI 01010 Il Il LI Li LI Ll LI LI Li Li Li ll 166 10000000 5000000000 Median Lethal Concentration 0oO00000 000000 ECso 10000000 5000000000 Median Effective Concentration 00000000 000000000 10 0 000 100000060 1080 000000 10 Effective Concenitration 00000000 LOEC 1 010 001 0 01010100001001 Observed Concentration 0000 00000 NOEC 100 0000 Observed Effect Concentration O0 1 13 10100000 LI LI LI Li LI L LI LI Li i Ll LI LI Li Li Li Li 00 00 72 960 HUU l 72 960 0000 ECso 2 NOEC LCso 210000000 96000 NOECO LCso 00000 00060 000 0000000000010 Ver 2 0 NEDO 2007 33 JEN H N WD N N i Hal 15 2 020100 00 000 000 010001010101001010101010101 mm BO DO DO 0 010103 N hill EE tH B 0000000000
25. H IFE a MAL IT DEET DIHAT PTE bi j rz CARA Kbps SHH d 7 EA R T1 EPT e a n RA A PA TT m A _ 8 j EHT H FR MA EPA ATA i ET EE TE U EH Sis N T EE Bi EEN rc EE UE HER ARANDA pb a 5 IN J ty MN r 27 ER Fij nm er Eyn PI BT TE AN PRO uri Ea rr ie SER Die i Ed A E EHR KE L Erih m4 HEW D z a k Eu 111 11 E 0 0 tia i PAL 14 CES 1154 T L kall Ea m ve Er gt Thaae 148 3 ba et i TA Ren L TEL CH it Pl E atra Ir pr TITI 2 11 i d E1 ger 0000000 janan mm BIB
26. NOAEL 000000000000000000000000000000 40000000000 NOAEL 0000 00 00 0000 000 00 000 0 0 0 0 Ll J j Ll 0 HI Li jJ ji 000000 1900001000 00000 m m Ll BL J 0000000 27 00000 14 00100 00 00 L LI 0 LI LI LI LI LI LI LI L L Li i LI LI L LI Li 24 0 0 J J Ll jJ Ll Li 00000000000
27. 90000 14000000 400400000410 2 4 HM H HOER N 01 28 U L BE B Ni E H N Oo Ho 00000 e DOBODOD L LL j U e DOBO 1 01 4 1 p 8 AQODOD DO DO OD J J 0 000 100 001000 ll j 0 100 j j 0 00 Li Ll i ji jJ ji ji Li 1 0 020 00 0 000 0 00 0 0 0 0 0 0 00001 moon 000 000 e000 rem 00 0 0 0000000000000 o L L m n u OTS A e 2700009000000 00000000000000000000000000000000 1 00000 ll j ll j HI
28. SC 0 0 He m u n gt ZAR _ Dav y so E gt AMORE 0 0 E E O dik Bi 2001 59 DPasquill Gifford Gifford 1961 UDDODD000000000000000000 0000 0000000000000 Ll Ll Li Li Li j 09 Normal 0 000000 41 2 0000 090000000000 MET LIS jpg90900000000000000000000000000000000000 000000000000000000 00000000000 METI 0850 1 00000000000000000000060060000000000 0000000000000000000000000006000000000000 0000000000000000000000000000000000000000 00000000000000000000000000006000000000000 0000000000000000000000000000000000000000 METI LIS 0 2603 01 000 00 0 0 1 00 0 0 0 0 0 0 0 5 0 0 0 000 00001011 METILISU L 2 N http www jemai or jp GAGHE tech details detailobj1816 cfm D00000000000000 METI LIST J TI J J UU U 0 METI LIS ver
29. ELENA B hipa ll j j j j J j j i Li ll U DO BO BB OOO U Ll Li ji J Li Li Li ll j j j j U D l l Ll J i Li TI H R BARE B R HER B H B Pl E 0 HHH HEE NR H N N B RR B B B N B N 0000000 2 00000000000 2 1 000000 Ll Ll Li J J J J J Li Li J jJ ji 0 000000 000 1 15000000 Li TN KI BERR B B B B R N R R B RR HEB B B RAN SUR BE 000000 B NR N HK PPS IDH Ll Li
30. UP 0000000000 15 UF L LI LI Li 0000 200000000000 2100000000 00000 Taman 0 0 10 On nn DO J Li LJ IJ O UUUDUUUUUD 02 5 CIE Hi OC Us 00000000 000 00000 O 10000 00 00 00 00000 000000 UFs O 000000 10 00000000 100 x 0 1 100 63 4 PNEC L 0 2 000000000 NOEC 8300000000000 UESO 0 PNEC 000000 O 00000 UFs 0 11 mg L 100 0 0011 mg L 5 0000 000 4 0000 0000000 0000 0 0000000 PNEC 0 0 0011 mg L 64 00003 0000
31. 000000 UFs 39 5 mg m 500 0 08 mg m 5 00 000 00 00000000 00000 000000 mg m 0 08 mg m 55 0000000000 5 0003 100000000 0000 0000000000000 000000000 UDUUUUUD 6000000000 1 1 10 10 j ji ji li T 3DAR E 5 FE ROHA TE T 1 i PATATA ET 1 1 4000000 50m 0000 0 123000000000 0000000000000000015m 000 Ll Ll LJ J J J J i 2003 LJ jJ 0 LJ Li ji ji ji ji 30 0000 0 00 0 00 0 00 0 00000 100000 00000000000
32. 7 1400000000000000000 53 000 0000000000 2 00000000000 00000000000000000000000000 NOAEL 00000000 000000000000000000000000000000000000000 0000000000000000000000000000000000000000 0000 000000000000000000000000000000000000000 NOAEL 221mg mMJ 00000000000 150mg m 000000000 NOAEL 150mo m 000000000000000000000000000000000000000 0000000000000000000000000000000000 000 28 14 000000000000000000000000000000000 NOAEL 1000000000 221 000000000000000000000 6 0 050 NOAEL 0000000 mg m O 0000 NOAEL 01000 24 00 0000 7 0 221 mg m 6 24 5 7 0 39 5 mg m NOAEL 0000 150 00000000000000000000000000 1000 000 8 4 0000000 0 0000 67 0000 600 70 1400 2201000 7140000002400 mg m O 0000 NOAEL
33. __0 sogon 100900 __ 0 Saa aaa aa 2 BES B B BER N 1 14 H NAR H H R LP Y T D 481051 MSDS 00000000000000000000000000000000 000 00 2 01 00 0 000 100000000000000000000000000000000000000 000 0 0 0 00 0 0 00 0 0 0 0 00 0 0000000000 UMSDS 00000000 0000 000000000000000000000000000 100000000000000000000000 30000000000 1 200 0000000000000 OU LI LI LI LI J HI Li LI j j jl Li Material Safety Data Sheet 2 GHS Globally Harmonized System of Classification and Labelling of Chemicals LJ Ll LJ J jJ J j 2003 000000 gt GHSUD0UUUUDO UI 1500000000 GKS L 000 000000 U htto www safe nite go jp ghs ghsi html 20
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35. 00000000 180 30 0000000000000000000000000 1200 0000000000000000 0000 00000000 j J 00 000 3 1 00 0 0 0 0 0 0 0 0 0 00 0 00 0 0 0 0 0 0 0 0000 1300000 0 0 0 0 01 11010101 0000010 000000000000000000 2 ll lJ OB j j BBB 0 00 i 1 J 00 0 h H B N REBER DAR B E ME a B D DOABO ED N DO hBi HH HL R PRIRODDO 9 0000000000 2 E B B BNI ee B N HERR PRTRODOD
36. 000000000000 39 00000 0000 9100000000000 ll j 10010 001 0 J Ll 00009100 0000000000 201 1 000000 001 2003 ll Ll j J 00 0 Li ji ji U 40 00000 0000 1 0000000 1 90000000000000 2 2 e 0 d 2 Ho e 0 Ea ppm mg
37. 42 2 l R B li 1 m HD HDH BD HL L j 0000 000 0 000 00 0 0 0 0 0 0 0 0 0 ANO 34 2 000000000000000000000000000000000000000 0000000000000000000000000000000000000000 0000000000000000000000000000000000000000 PA 0000000000000 1 140 5050000 90000000000000000000 UP 00000000000 000000000000300000000000 300000000000000 00000000000000000000300000000000 30000000 00000000000000000000000000 0000000000000 000000000 1130000000000 00000000000000000000000000000 U 0000000 0000000000000000000000000000000000000000 000000000000000000 Y 1 14 0000000000000 UF UF 00 10 5 DODOD Ver 2 0 NITE 2007 514 0000000 UFs UFs y 90000 0 0 20000800000 10000 0000000 35 UDUUUUUUUUUD 0 00 0 NOEC
38. LOAEL NOEL NOAEL 10 I 250 1000 1500 my og ER 7 0000000000000000 0000 26 L LI Li LI LI LI LI LI LI LI Ll L Li LI LI LI LI LI LI Li Li Li Ll B D H LD B U j 0000 NOAELII 0101001001000 01000 NOAEL 000000000000 m HL DH D 0 0101 01001010 010110 NOAEL ll Ll J j 2 01111100 J 0000000 NOAEL DO J BOO j BB j j j j j j Li 0000 j Ll BB 0 Ll Li Ll
39. 0000000000 66 00004 00000 OOOO 200000000000 0000000000 30000000000000 HQ 000000 0 000000 0000 mg L 2 7x 10 4 mg L 0 0011 mg L 0 25 HQ O 0 250 10000 00 0 0000 00 0 0 0 00000 00000 6090 000000000 6 Ll iJ Ll Li j Li Li LH N Li f 00000 000000000000 RD U KK 0 0 10 ESO 00000 9601 Ba 8 Dorn et d 1993 000000 j 00000000 m saa 11101 88111 1989 WL ESO LOQ WL HENA H B N HEB N LG lt 50 LGA 0 er 1979 o mae 1 410007 _ Ooms 00000000000 60 1 9 03 7 03 UU AJ Dia EN a TTT Dn DH HPH Z21 2 2 5 El 0 5 SS NEO y NAS NI Nr N Q
40. 500000000000 Ll Ll Li Li Li j 0000 000000100 ll J i J 010 Li ji ji U DO do IJ J i l1 li Il 00000 800Pa 20 0 2 DUDU qu CT 02000000 700 900Pal 0 0 00 IPCS 2002 50 00002 UUUUUUUUUUUUUU 1 1700 18 23 24 00 0 0 0000 0000000000 5000 000 00 00 0 00 0 0 00 0000 UU U 0 011010101010 11 0 00 000 0000 0000 1 1 www safe nite go jp risk nedotop html O O U O O mite saaa 21 r R hesin E YEW BER ETN ETT TE Eran hitit e Bes A CERS FT iF Turi ege bes i samasaa ml Fe m mesma H m Ge azan AA EFT dili i TF IE SEL EF U 4 Tu
41. BA BAN 1 8 E hr 2 RE ER EB 22 OCH O0 100000000 38 00000 2 00000000 1 8 0 DABA j j j 10 0 j Ll J LJ j ji ji ji ll j j j j 1 j j DO ODO i Ll 0090000009100 I1 ll Ll IJ Ll LJ J L I1 i J j l1 UU Mackay 2001 0000000000000 ll Ll Li J j j O0 4811 001 00 00001050 0010100100010010100100 1 L Ll Li Li li 000 St SHANEL 008000 A ST RAVIH PRZM 000000 000000000 NEDO CRM 2006 8 000000000 J J 000 1 0 000 000000000
42. 1986 0 0 0000005 0100000 00000000000001000000000000000 180 00000 UUUUUU 500 0 Ll LL 70 14 NOAEL 150 mg m 000 Ungvary etal 1980b 000001 0000 000 00000 110 000000000000000000000000000000610 15 00000 Ll Ll LD DO DO DO DO DO J i J J J J LJ LJ LJ J LJ J LJ NOAEL 1 030mg kg 000 0 Marks etal 198200000 000000000000 NOAEL 000000000000000000000000000000000000 OOO DO DO DO DO O OB ODO J LJ LJ J 2 DS ET H H Dr H DEL TH 0 0 000 0000000000 00 0000000000000000000000000000000000000 J J Ll Li LJ J Li 9 2 2 1 1000000000 KH NOAEL 50ppm 221 mg m
43. O DD ODO LH HH OOO 0O HL TH T N L gag J BO DO Li 20010000 J i Ll Li Li jJ Li Li LI LI LI LI Li Li U l B 1 00 000100 0 0000 01001000 http www1 river go e 0 11600 DABA J j 0 L J Ll 9000000090000 2 Li Li ji ji ji 900000 0000000100010 U 010 0 20101 0 01010010 Ll Li Ll J 00 LJ J J jJ 9500000000000 0011 01865 i Ll LJ ji jJ ji Li Li DOBa LJ j Ll 250 ji Ll Li i jJ Li Li Li DOBa LJ J J 0535 00 1100 D00000000000 00000000000 000 NEDO 00000000 1 DO J J LI DI LI J LI 0000000000000 000 00001010000 Ver 2 0 CERIN NITE 2007 140000000000 44 00000 0000 II LJ jJ j
44. U THE i DU A geng D Ta Dax 1 hi 7 ii 11 1 SEITZ B CAL a 51 ll j J 10000 Et E HEB B Ver 1 1 Ea 1 43 CAS L n Set Wiz d NIE ii EN ihm 200922 000000000 000000000 0000000 0 52 N E EE ILI LI LI J LI LI L L LI L D LI L L 09 22 9 2 2 0 000 000000 00000 0 NOAEL 50 ppm 221 mg m Korsak et al 1994 6 5 0000000000000000001000000000000000 29 00000 2344 0000 103 000000000000000 NOAEL 250 mg kg 5
45. x 01000 24 00 0000 7 0 150 mg m 24 24 7 7 150 mg m 39 5 mg m 150 0 0000000000000 D0000000000000000000000 39 5 mg m 000000 54 EE 3 2 NOAEL 0000000000 ll j j 0 j j DD J J LJ ji J jJ Ll i NOAEL 0000000000 000 00000 00 0 00 000 0 0 0 0 2 01 0 00 00 0 0 1 11 20 0 00000000 UF 0000 DUO Ll dB BE BB 00 0 J Y 2 11 0010 LI Li Li Li Li 000000 I0000000uF 0000000000 00000000 0 2 0000 1 2 000 En ____ ____ 0000000 00000 3000 ___ O UFs 0 00 10 x 000 10x 1 x 5 500 4 0 00000000 NOAEL 3 0000000000 UFs Ll ll LJ 0 0 DO 01 10 01 0 ji ji 000000 mg m 0 000000000000000 NOAEL
46. HI Ll i j LI 90000009100 19 000000 ll ll li lI J j j TIL 17 100 00000000 Ll Li Ll LJ i LI J J 45 7 00000 2 j j J 2 00000 00000000000000000 Hazard Quotient Ll Li Li Li Li j 000000000 1000001000000000000000 DOBa j LJ j J Ll Li ji ji 71 _0000000000000000000_ 0000 200000000000 00 000000 0000000000000 000000000000000000000000000000000000000 0000000 00000 000 1000000000000000000000000000 D0000000000 0 00000 00 HQ 0 HQ e 372 2091 T 1 1 46 EE D000 200000000000 0000 000000 300000000000 00000000000000000000000000000 HQ 0000000 00000 000 1000000000000000000000000000 0000000000000 HQ 0 00000 mg 00000 0000 mg L E ze RS
47. 0000000 Do0000000 0000000000 0000 000 ll 0000000000000000000 0000000000000 0000000 maa La i i Hi N li 000000000000 51000000000 0000000 D HAE Y O HERE 0000 gt Y Y Y Dm i ji N TINE 0000 00000 15 210000 010 001 01 0 05 1 6 190 30000000000 2005 WHO air quality guidelines for Europe 20081 11111111 1 U http www euro who int air activities 20050222 2 0 0000000000000 180 120 DODBO J LJ J LJ DO ODO B LJ T LJ J J J J LJ UU Ll TI LL LL LD EEL H N BS u n hi u L L LI i i D h H EE EUR EH EE EECH EEE DEEL 1 MSDS 2 3
48. 1100000000 B H HE FE I 0 500 950 I 7 Hi ji U HIEL HH HOER H 10 6UUUUUUO 00 000 11111111 000000000000000006 9000000000000 90000000000 ll J j 11 Ll Ll Ll LJ LJ J jJ LJ j ji ji Li 000000000000000000000 OGLP Good Laboratory Practice 000000 0 B EB D B R N a 10 20 HUB 1 505 50000000 00000 16000000000000000 0 11 000000000000 16
49. 00 1 1 DO Ll L Li ji 2 Li 0 0 MSDS U ll user anzen kag kag main01 html 0900000000 http www jaish gr j 6 22 H N BS 2 aa B Phi E BE 01101010101010110101110101110 0 000000 0000000000 0000000000 0 000000000 00000000000 000 0000000000000 000000000000000 000 0 000000000 0000000 000 0000000000000000 300000000 000000000000000000000000000000000000 1009000000 1 7 http www safe nite go jp data sougou pk list html t able http www safe nite go jp risk riskhykdl01 html 0000000000000 http unit aist go jp crm mainmenu 1 html 115 http www env go jp ch
50. 1 1 47 48 00 Ll Ll Ll i j J J Jl Ll Li ji Ji 2 J J II J i J Ll Ll LI LI LI LJ Li J i J ll HI j 11000 J J 0000 0000000000 00000 49 00001 000000 o ll J J j DO Li ji ji j 0000 DOBa j 0 LJ Li ji ji 0U000000000000060
51. 2 BEN 4 L B E EH E HU http unit aist go jp crm mainmenu METI LIS note novO5 pdf 5 0000000000 1 4 9 000000000000 000 2005 1 190000000 1 19000000000 ll j 140 0 00 0 0000 0 0 0 0 0 0 EEE 1 4 9 00000000000 7900 10m 2201 00000000006 J 00009000 150101 J J J LJ 50 N H HE 000000000000000000000000000 M L L L H O B D E Ministry of Economy Trade and Industry Low rise Industrial Source dispersion MODEL 42 Ll Li li li l AM Sal Wm I 1010110015 005 01 01 05 7 n 2005 110 1 4 9 1 0 000000000000000 6100000 43 ll j j j j ODO j j j j 11 0000100 ll J j j O J 0000010000
52. J Ll J Li Li jJ ji e 0000000000000000 ll j j j j j DO j j j J j Ll 0000100 Ll Li Li J 0 11000 ji ji ji e e 00000000000000 e 0000000 0 2 0000 00000000000 000000000000 ll j j j j DD Li e UUUDDUDUUUDDDUI e 11 1 0 L Li i Li ji ji U e Ll i i J j J 0 0 jJ J J LJ jJ ji ji 0000000000600 200000 4 10 8 11 0 000 0 0 1 4000
53. nite go jp risk riskhykdl01 html 0 400000 0000000000 NEDO40 000 0000000 CERDO 0 0000000000 2005 1 00 No 62 0 400000 0000000000 0000000000 CERDO 2005 Ver 1 0 0 0 00 0 0 00 OD 00000000060 0 NEDOL 1 0000000 000000 1 2006 0 900 0 http unit aist go jp crm mainmenu 1 0 1 html 2006 GHS 000000000000 00 18 02 15 000 000000 http www safe nite go jp ghs list html 70 00 182410 0000 0000 000 0000 0000 2005 00000000000 2 1400000 0 000000000 00000000000 2002 00000000000 2003 _ 00000000000000 00000000 0000000 001 0 010010 997 tiap 2003 00000 000000 00000000000 0000000 0001000000 2003 000 0000000000000 IPCS International Programme Chemical Safety 2002 International Chemical Safety Cards Geneva Gifford F A 1962 Use of Routine Meteorological Observations for Estimating Atomospheric Dispersion Nuclear Safety Vo
54. 0 ABAD O DO O O DO DO LI HI LI LI LI LI LI LI 1 LJ LI LJ LI LI LI j 1 000000000 NOAEL 2 00000000000 UFs 0 00000000000 97 000000 4 00 000 00 00000000 EE OD UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUN 2000000 UUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUOUUUUU 0000000000 1 000000 0 1 12000000000000000000000000000000000 0000 1 13 ll j j J j j j j i Li 0010 0 01000101 NOEC
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