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Contents
1.2. 15 250 ml Y
3. g g N NI H 14 ICA0 IATA IMDG Hp 15
4. 57 1 30 57 2 18 2 4 4 MI 4 4 MDI 326 75 2 35 MDI 1 2 4 1 53 36 PRTR MDI 0333 8 10 2010 06 23 H 4 4 MDI 448
5. 9 9 q 7 ieser 4 2 2B 1 MDI 0333 2 10 2010 06 23 H 1
6. E 10 ZEN MDI 8 Shara ely ves E CERO H iit Ao 4 10 2010 06 A 23 90 95 5 10 0 2 2
7. ses i RE MILT OMAR HAGA a
8. LAL CO ORBIT AAC e OF A ARH CD Ott 2002 PRU Ott Diler and Jolly 2003 3 xY P Y E MDI E 4 Q TE Pauluhn 2000 Kilgour et al 2002 1 3 MDI 0333 7 10 201042 06 23 GHS UNECE 2003 3 9 1 6
9. IARC 1999 19 Ae MI 50 MDI CHER MSDI Weyel and Schaffer 1985 Pauluhn et al 1999 MDI MDI lite E 3 3 SM aR ee MDI f EC 2005 9
10. xy RY I EOTUERR G RA ORUN ZE 30C 10 8 Kin HEAR ay eS I alt TWA JIS T 8155 oe
11. MDI 11 MDI 50 MDI LD50 gt 5000mg kg Wazeter 1964a 2 MDI 50 MDI LD50 gt 5000mg kg Wazeter 1964b GHS
12. Y 38 30 2 3 37 17 AFUE 4 Be Fc RD A 1 15 16 Ore T O ONES a a je re 12 13 14 15 16 2005 2008 MDI 2009 MDI 1996 M H Litch Field Review of MDI Toxicity Studies III Ref 10844 7 1991 312 2 5 2009 TARC Monographs 2006 TLVs AND BEIs 2010 ACGIH
13. MDI 0333 3 10 2010 06 23 exe 3 44 MD 1 98 CREES 4 118 54 6 29 CAS No 101 68 8 4 26447 40 5 4 E MD I 4
14. 5 MD I MD I 6 TRO i USN m
15. Ae FEl 3 bc te aie Da
16. 4 2 MI BEU R36 2B EC 2005 Vandenplas et al 1993 EU et al 1993 EU R43 1 EC 2005 MDI Seel et al 1999 JETOC 1982 Pauluhn et al 2001 7 MDI
17. GHS 4 4 MDI 4 4 MDI 50 MDI 0 003ppm at 20 C Allport et al 2003 MDI LC 4 490mg m Appleman and de Jong 1982 23 TT Oy MDI 0333 2010 06 23 6 10 Te ATA CFBAE SAE ef SA BRS CBEST SH Lita RERO RREZE lt HEV EC 2005 9 EU MDI Harmful Directive 67 548 EEC 25th ATP Dir 98 8 EC 0 J 30 12 1998 BC2005 EU
18. GHS MDI 1 12 LC50 gt 1000 mg L NOEC gt 1640 mg L Blom and Oldersma 1994 13 MDI
19. MDI and TDI Safty Health and Environment edited by D S Gilbert etc 2003 Allport D C Gilbert D S and Outterside S M Eds 2003 MDI and TDI safety health and the environment A source book and practical guide Wiley Chichester ISBN 0 471 95812 3 Appelman L M and De Jong A W J 1982 Acute inhalation toxicity study of polymeric MDI in rats III Report No 10077 International Isocyanate Institute Manchester UK Bernstein D I Korbee L Stauder T Bernstein J A Scinto J Herd Z L and Bernstein I L 1993 The low prevalence of occupational asthma and antibody dependent sensitization to diphenylmethane diisocyanate in a plant engineered for minimal exposure to diisocyanates J Allergy Clin Immunol 92 3 387 96 Blom A J M and Oldersma H 1994 Effect of Desmodur 44 V20 PMDI on the growth of the green alga Scenedesmus subspicatus III Report No 11156 International Isocyanate Institute Manchester UK Available from British Library Document Supply Centre Boston Spa Wetherby West Yorks CEC 1998 Commission Directive 98 98 EC of 15 December 1998 adapting to technical progress for the 25 time Council Directive 67 548 EEC on the approximation of laws regulations and administrative provisions relating to the classification packaging and labelling of dangerous substances Off J Eur Comm 41 L355 30 Dec 386 9 EC 2005 Methylenediphenyl diisocyanate MDI CAS n
20. Kie FAKI MDI 0333 IK A REET 7 AW 8 E Eis H HH H tA AN MDI gg ao
21. TWA 0 05 mg m 2009 EI 0 005ppm 0 051 mg m3 2010 AAV AZ JIS T 8153 MDI 0333 5 10 2010 06 23 9 pH gt 300C 38 iC W 6 7X10 Pa 25 1 8 5 4 4 MDI 1 22 43 ITFA 4 7 5 0 mPa s 507 0
22. Re MDI Hoymann uzel et al 1990 MDI 1 R38 Rattray et al 1994 E R42 1 EF EC 2005 Thorne et al 1987 Bernstein E 1 17 et al 1995 MDI B APSR EIT IARC 3 MDI MDI REZ ARDA MAK Mak Values Vol 45 2008
23. 1 5 EJAVYIMDI 0333 1 10 1993 03 31 2010 06 23 MD I 1 Monomeric MDI 4 4 MDI FAX MSDS No 0333 GHS URI E kI
24. nd Med 50 3 213 28 Wazeter F X Keller J G Buller R H andGeil R G 1964a Toluene diisocyana TDI and polymethylene polyphenylisocyanate PAPI acute toxicity studies LD50 male albino rats Unpublished report by the International Research and Developme Corporation Wazeter F X Buller R H and Geil R G 1964b Toluene diisocyanate TDI a polymethylene polyphenylisocyanate PAPI acute dermal toxicity studies LD50 in the albino rabbit Unpublished report by the International Research and Developme Corporation Weyel D A and Schaffer R B 1985 Pulmonary and sensory irritation dipheny1methane 4 4 and dicyclohexylmethane 4 4 diisocyanate Toxicol Appl Pharmacol 77 427 33 A te in nt nd nt of Gesundheitsschadliche Arbeitsstoffe toxikologish arbeitsmedizinishe Begrundungen von Mak Werten Maximale Arbeitsplatzkonzentrationen H Greim ed Vol 45 2008
25. o 26447 40 5 EINECS No 247 714 0 European Union risk assessment report Volume 59 Report EUR 22104 EN European Chemical Bureau Ispra VA Italy Available from lt http ecb jrc 1t DOCUMENTS Existing Chemicals RISK_ASSESSMENT REPORT mdireport304 pdf gt Accessed 17 Oct 2006 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 MDI 0333 9 10 201042 06 23 Hoymann H G Buschmann J Heinrich U and Bartsch W 1995 Untersuchungen zur chronischen Toxizitat Kanzerogenitat von 4 Methylendiphenyl Diisocyanat MDI Band 1 3 Forschungsbericht 116 06 084 Fraunhofer Institut ftir Toxikologie und Aerosolforschung Fh ITA Hannover Germany IARC 1999 4 4 Methylenediphenyl diisocyanate and polymeric 4 4 methylenediphenyl diisocyanate In IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Vol 71 Part 3 Re evaluation of some organic chemicals hydrazine and hydrogen peroxide International Agency for Research on Cancer Lyon ISBN 92 832 1271 1 Pp 1049 58 JETOC 1982 Micronucleus test hexamethylenetetramine and 4 4 dipheny1methane diisocyanate Japan Chemical Industry Ecology Toxicology and Information Center Tokyo Japan Kilgour J D Rattray N J Foster J Soames A and Hext P M 2002 Pulmonary responses and reco
26. of exposure Toxicol 88 15 30 Reuzel P G J Arts J H E Kuypers M H M and Kuper C F 1990 Chronic toxicity carcinogenicity inhalation study of polymeric methylenediphenyl diisocyanate aerosol in rats 3 vols III Report No 10749 International Isocyanate Institute Manchester UK Seel K Walber U Herbold B and Kopp R 1999 Chemical behaviour of seven aromatic diisocyanates toluenediisocyanates and diphenylmethanediisocyanates under in vitro conditions in relationship to their results in the Salmonella microsome test Mutat Res 438 109 23 Thorne P S Hillebrand J A Lewis G R and Karol M H 1987 Contact sensitivity by diisocyanates potencies and cross reactivities Toxicol Appl Pharmacol 87 155 65 UNECE 2003 Health and environmental hazards In Globally harmonized system of classification and labelling of chemicals GHS Part 3 Health and environmental hazards UN Economic Commission for Europe ISBN 92 1 116927 5 Available from http www unece org trans danger publi ghs ghs_rev00 English GHS PART 3e pdf Accessed 2 Oct 2006 Vandenplas 0 Malo J L Saetta M Mapp C E and Fabbri L M 1993 Occupational asthma and extrinsic alveolitis due to isocyanates current status and 32 33 34 35 MDI 0333 10 10 2010 06 23 perspective Brit J I
27. very following single and repeated inhalation exposure of rats to polymeric methylene diphenyl diisocyanate aerosols J Appl Toxicol 22 371 85 Ott M G 2002 Occupational asthma lung function decrement and toluene diisocyanate TDI exposure a critical review of exposure response relationships Appl Occup Environ Hyg 17 12 Dec 891 901 Ott M G Diller W F and Jolly A T 2003 Respiratory effects of toluene diisocyanate in the workplace a discussion of exposure response relationships Crit Rev Toxicol 33 1 1 59 Pauluhn J Emura M Mohr U Popp A and Rosenbruch M 1999 Two week inhalation toxicity of polymeric diphenylmethane 4 4 diisocyanate PMDI in rats analysis of biochemical and morphological markers of early pulmonary response Inhal Toxicol 11 1143 63 Pauluhn J 2000 Acute inhalation toxicity of polymeric diphenyl methane 4 4 diisocyanate in rats time course of changes in bronchoalveolar lavage Arch Toxicol 74 257 69 Pauluhn J Gollapudi B Hammond T Linscombe A Thiel A and Zischka Kuhbier D 2001 Bone marrow micronucleus assay in Brown Norway rats exposed to dipheny1 methane 4 4 diisocyanate Arch Toxicol 75 234 42 Rattray N J Botham P A Hext P M Woodcock D R Fielding I Dearman R J and Kimber I 1994 Induction of respiratory hypersensitivity to diphenylmethane 4 4 diisocyanate MDI in guinea pigs Influence of route
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