ビスフェノールA について
Contents
1. a 1 80 240 BPA 3 5 A Bisphenol A update EFSA calls meeting and invites contributions from Member States 2 February 2010 EFSA http wwwr efsa europa eu en press news cef100202 htm2. H E robustness 1 E a hh E
3. CERHR BSC BSC NTP BPA Qc F 8 EF NTP BPA 2007 8 NTP CERHR 2
4. 4 FSC BPA MHLW 2008 FSC E FSC web BPA 1990 BPA BPA MHLW BPA
5. 31 FDA BPA BPA FDA BPA replicates
6. A CRPA 1999 64 a 64 c A Q amp A Questions and Answers for Action on Bisphenol A Under the Chemicals Management Plan http www chemicalsubstanceschimiques gc ca faq bisphenol a_qa qr_e html A A A
7. NOAEL 47 5 mg kg bw day LOAEL gt 475 mg kg bw day NOAEL 4 75 mg kg bw day LOAEL gt 47 5 mg kg bw day 5 3 A FDA A A A unlikely 31 44 LOD 0 9 ng m3 51 5 ng m3
8. robust BPA a BPA 2006 EFSA 3 2002 1 NOAEL 5 mg BPA kg NOAEL 5 mg kg 2 7
9. f A A j 100 g kg bw day 0 048 gp g kg A f 2 H A
10. A 1 Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults Lang 1A Galloway TS Scarlett A Henley WE Depledge M Wallace RB Melzer D JAMA 2008 Sep 17 300 11 1303 10 2 Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovarnectomized nonhuman primates Leranth C Hajszan T Szngeti Buck K Bober J MacLusky NJ Proc Natl Acad Sei USA 2008 Sep 16 105 37 14187 91 2 0 A Government of Canada Protects Families With Bisphenol A Regulations October 17 2008 http wwwr hc sc gc ca ahc asc media nr cp 2
11. 1 BPA BPA
12. E f E r 2 39 E E
13. ALARA WHO FAO BPA 2010 BPA E BPA 2010 10 50 E 1 EFSA 2006 No 3 2007 p 22 http wwwr nihs go p hse food mfo foodinfonews 2007 foodinfo200703 pdf 2 EFSA No 16 2008 p 17 http
14. A A
15. Bisphenol Ain Beruhigungssaugern Untersuchungsergebnisse des BfR Information Nr 039 2009 des BfR vom 03 November 2009 http www bfr bund de cm 216 bisphenol_a in_beruhigungssaugern untersuchumgserg ebnisse_des_bfr pdf 1 No 28 2009 p 24 http wwwr nmhs go p hse food info foodinfonews 2009 foodinfo200923 pdf 3 1 A BPA WHO EAO BISPHENOL A BPA Current state of knowledge and future actions by WHO and FAO INFOSAN Information Note No 5 2009 BisphenolA 27 November 2009 WHO http www who int foodsafety publhcations fs_management No_05 Bisphenol A_Nov09 en pdf Ao 22 009 A BPA
16. Butler FSANZ j HH 2010 9 x http www nihs go jp hse food info index html 62
17. 2 http www nhs go jp hse food info foodinfonews 20097foodinfo200906 pdf 2 No 12 2009 p 26 Q amp A http wwwr nmhs go p hse food info foodinfonews 2009 foodinfo200912 pdf 3 3 A 2010 1 Update on Bisphenol A for Use in Food Contact Applications January 2010 01 15 2010 FDA http www fda gov NewsEvents PublicHealthFocus ucm197739 htm No 09 7 A BPA 1960 standardized toxicity tests BPA subtle effects
18. NZFSA NZFSA NZFSA 2 10 A BPA Bisphenol A BPA FDA http www fda gov oc opacom hottopics bpa html No 11 008 FDA 2008 4 14 BPA FDA
19. BPA BPA BPA EE E AFC BPA E
20. A A A 3 A 170 2008 10 18 60 2009 21 A
21. Hearings Plastic Additives in Consumer Products http commerce senate gov public Consumer Affairs Insurance and Automotive Safety May 14 2008 http commerce senate gov public index cfm FuseAction Hearings Hearing amp Hearing_ 1D d8894142 44e0 4a06 999c 05811a11938c Ao 77 0 2 A 2008 5 14 2 FDA CPSC American Chemistry Council 5 witness
22. EFSA JRC Joint Research Centre ECB 4 2008 RFSA 2006 EFSA VKM 2008 5 EFSA NOAEL 5 mg kg bw NOAEL
23. kNS A CEPA 1999 toxic 18 A A A
24. A A A BfR Q A A A TDI 0 05 mgykg 100 TDI A TDI
25. A A Y 44 BfR Q A A BfR
26. NTP 5 some concern FDA 8 9 16 A minimal concern BPA negligible concern lt ml No 18 2008 FDA
27. 7 A Bisphenol A BPA and food packaging 17 April 2008 FSANZ http wwwr foodstandards govau newsroom factsheets factsheets2008 bisphenolabpaan dfood3898 cfm No 9 0 FSANZ BPA A BPA BPA BPA
28. E 1H EFSA A No 04 010 54 EEFSA A BPA 4 EU 2010 5 CEF BPA EFSA 2007 1 1 2008 7 2 BPA EFSA 2009 10 BPA TDI
29. BPA A BPA BPA BPA BPA BPA 39 ami BPA
30. AFC TDI 0 05 mg kg 8 100 AFC TDI 2002 TDI 500 substantial 100 2 2 2 4 AFC Opinion of the Seientific Panel AFC related to 2 2 Bis 4 Hydroxyphenyl Propane 29 January 2007 http wwwr efsa europa eu en science afc afc_opnions bisphenol_a html AFC A BPA A 2 2 4
31. TDA Norris Alderson 21 Statement of Norrns Alderson Ph D Associate Commissioner For Science Before Subcommittee on Consumer Affairs Insurance and Automotive Safety Committee on Commerce Science amp Transportation United States Senate May 14 2008 http commerce senate gov public files AldersonFDA_51408BPATestimonyEFTNAL pdf A BPA FDA 4 17 Alderson NTP FDA BPA BPA FDA BPA 2007 2007
32. 80 90 FDA BPA 2 42 g kg bw 0 185g g kg bw FDA BPA NOAEL 2 5 mg kg bw NOAEL 2 000 27 000 NOAEL
33. BfR A 173 A BfR 2 BfR A ON OR A CN CO A Et RR A BfR 50 40C 5
34. A A 3 8 A high production volume chemical 2 12 A CERHR 1 A A 1
35. 6 FT 97 2008 10 31 FDA Science Board http www fda gov ohrms dockets ac 08 briefing 2008 4886b1 index html BPA http wwwr fda gov ohrms dockets ac 08 briefing72008 4386b1 05 pdf GLP
36. A AFC Toxicokinetics of Bisphenol A Scientific Opinion of the Panel on Food additives Flavourings Processing aids and Materials in Contact with Food AFC 23707 2008 http wwwr efsa eu int EFSA efsa locale 1178620753812_1211902017492 htm AFC BPA BPA BPA BPA 6 BPA 28 BPA 4 detoxication pathways
37. LL BPA 4 FDA BPA f E correlation BPA causation
38. 1 0 25xg 5 A 4 5kg 5 46 0 25ug A TDI 1 A 1 A 10ug 1 A
39. A NTP some concern NTP NTP 7 1 Es DI
40. 2 gt Ot 10 HH 0 001 mg kg bw 7day 0 0016 mg kg bw day 0 00037 0 00048 mg kg bw day bw day lt 0 002 pg 0 45 g kg bw day y 5 4 challenging A
41. AFC BPA NOAEL 5 mgykg 100 TDI 0 05 mg BPA kg conservative TDI 830 BPA BPA 2 3 A FAQ FAQ on Bisphenol A 29 January 2007 http www efsa europa eu en press_room questions_and_answers faq_on_bisphenol a h tml EU
42. BPA E 2 58 E BPA A AFSSA Bisphenol A AFSSA provides further informatnon on the critical exposure period 23 March 2010 http www afssa fr PM9100K610 htm AFSSA Ao 5 7 A BPA Gin BPA
43. 1 No 8 2007 p 22 http wwwr nihs go jp hse food info foodinfonews 2007 foodinfo200703 pdf 2 No 16 2008 p 27 http wwwr nhs go p hse food info foodinfonews 2008 foodinfo200816 pdf 3 6 EU A European Union Risk Assessment Report 4 4 Tsopropyhdenediphenol Bisphenol A February 2010 Final Approved Versnon awaitng Publication JRC http ecb jrc ec europa eu documents Existing Chemicals RISK_ASSESSMENT ADDE NDUM bisphenola_add_ 325 pdf No 04 7 A 2003 EU 2008 PDF 695 6 6Mb 37
44. FDA FDA FDA TFDA FDA FDA
45. ye ee FDA A FDA A IE FDA BPA FDA A 18 BPA
46. BfR A A BfR BfR A Bisphenol A in Beruhigungssaugern http wwwr bfr bund de cm 216 bisphenol_a in_beruhigungssaugern pdf 3 0 A BfR Bisphenol A in dummies BfR study results 3 November 2009 BfR http www bfr bund de cm 230 bisphenol_a_in_dummies_bfr study_results pdf No 24 0 BfR 18 A BPA BfR
47. FDA 1 38 23 A 13 November 2008 AFSSA http www afssa fr PM9100C310 htm No 24 008 EFSA 2006 A TDI 0 05 mg kg EFSA A 1L 50ug APSSA
48. FDA RFSA AFC BPA FDA BPA BPA 1 1
49. AFSSA 56 3 8 NZFSA Chief Rxecutive s column http wwwr nzfsa govt nz publicatioms ce column NZFSA NZFSA web NZFSA No 04 7 BPA CE s column The risk of BPA decisions made by public opinion February 2010 http wwwr nzfsa govt nz pubhcations ce column ce web column bpa htm A BPA FDA BPA do an about face FDA BPA
50. NOEL 5 mg kg bw day BPA 1 FDA 7000 7000 FDA 22 reasonable certainty of no harm under the intended conditions of use BPA FDA 2007 11 26 NTP CERHR BPA minimal concern 2008 4 14 NTP Draft Brief CERHR some concern
51. 709 1 100mL 50mL BPA BPA HPLC 2 MS 1 BPA0 05g BPA 0 0157g 0 8z g L 1 g L 18 17 BPA 1
52. 2006 APC TDI 36 Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults Lang TA et al JAMA 2008 Sep 17 300 11 1303 10 Epub 2008 Sep 16 2 2 A BPA FDA FDA Statement on Release of Bisphenol A BPA Subcommittee Report October 28 2008 FDA http wwwr fda gov bbs topics NEWS 2008 NEW01908 html Ao 29 008 FDA 2008 8 BPA FDA Science Board subcommittee Subcommittee report 10 31
53. A A 2009 78 H A EN i 137 ng g 534 ng g 61 4 4 A Government announces BPA baby bottle phase out 80 June 2010 http www foodstandards govau scienceandeducation newsroom mediareleases mediar eleases2010 7government
54. FSANZ 2 5 A BPA Bisphenol A BPA and food packaging May 2009 FSANZ http wwwr foodstandards govaunewsroom factsheets factsheets2009 bisphenolabpaan dfood4218 cfm No 12 009 3 2 4 BPA EFSA BPA BPA 1 safe limit EFSA
55. 1 18 A 41 Canada Gazette Part 1 75 1 No 22 2008 p 80 http wwwr nmhs go p hse food info foodinfonews 2008 foodinfo200822 pdf 27 A Ao 72 009 1 A Survey of Bisphenol A in Baby Food Products Prepackaged in Glass Jars with Metal Lids July 2009 http www hc sc gc ca fn an securit packag emball bpa bpa_survey summ enquete eng php
56. EESA 2007 1 A EESA TDI 0 05 mg kg bw ADI A EFSA EFSA 2008 7 1 3 FDA A FDAs Chief Scientist Asks Science Board Subcommittee to Review Research on Bisphenol A June 6 2008 FDA http wwwr fda gov bbs topics NEWS 2008 NEW01847 html Ap 79 008 2008 4 FDA
57. FDA BPA pdf 105 1 No 11 2008 http www nihs go jp hse food info foodinfonews 2008 foodinfo200811 pdf 2 No 13 2008 http www nihs go jp hse food info foodinfonews 2008 foodinfo200813 pdf 8 No 25 200 http wwwr nhs go p hse food info foodinfonews 2007 foodinfo200725 pdf 4 21 CFRS170 3G Safe or safety means that there is reasonable certainty in the minds of competent sclentists that the substance is not harmful under the intended conditions of use 5 No 9 2008 http wwwr nmhs go p hse food mfo foodinfonews 2008 foodinfo200809 pdf 1 8 NTP A NTP Finalizes Report on Bisphenol A 3 September 2008 NTP National Toxicology Program
58. 60 A NTP some concern some concern some concern minimal concern one step high concern 2 NZFSA NZFSA
59. A 10 A EFSA 2006 EFSA k 24 A BPA Bisphenol A BPA and food packaging 11 March 2009 FSANZ http wwwr foodstandards govau newsroom factsheets factsheets2009 bisphenolabpaan dfood4218 cfm Ao 6 009 FSANZ
60. NTP PO HP BPA NTP EN re et FDA CERHR 2008 4 NTP FDA BPA FDA BPA BPA
61. characterization FEDA Dr Andrew von Eschenbach The FDA this Week Andy s Take http www fda gov oc vonEschenbach andys_take default html A October 31 2008 FDA A BPA TFDA FDA FDA FDA
62. FSANZ Consumer Commission ACCC BPA BPA No 02 7 Ee i ul FSANZ Q amp A 1 No 6 2009 1 p 28 Q amp A 51 BPA EU TFSANZ
63. 2009 5 12 Environmenta Health Perspectives EHP A A 77 A BPA 1 FSANZ BPA BPA BPA
64. AESSA 1 29 Opinion of the French Food Safety Agency on the critical analysis of the results of a study of the toxicity of bisphenol A on the development of the nervous system together with other recently published data on its toxic effects http www afssa fr Documents MCDA2009sa0270EN pdf TDI TDI BPA
65. A A 3 NTP A A E negligible concern 2 A i A
66. EFSA No 3 00 1 EFSA A TDI EFSA re evaluates safety of bhsphenol A and sets Tolerable Daily Intake 29 January 2007 http wwwr efsa europa_ eu en press_room press_release pr_bpa html 1 29 BPA EFSA AFC 3 BPA 5 2002 1 EFSA A BPA BPA TDI full TDI TDI BPA TDI
67. NZFSA FDA BPA BPA BPA BPA BPA
68. 45 A Q A A A NN Ausgewahlte Fragen und Antworten zu Bisphenol A in Babyflaschchen und saugern Aktualhisierte FAQ vom 2 Oktober 2009 http www bfr bund de cm 276 ausgewaehlte_fragen_und_antworten_zu_bisphenol_a_i n_baybflaeschchen_ und_saugern pdf 2 9 A Bisphenol Ain dummies 26 October 2009 BfR http www bfr bund de cm 230 bisphenol_a in_dummies pdf Ao 29 0 9 A BfR A
69. FDA 1 2 4A 5 Bisphenol A EFSA http wwwr efsa europa eu EFSA KeyTopics efsa_locale 1178620753812_BisphenolA ht Im Ao 72 008 EFSA NTP A A ue 23 A
70. unlikely BPA EFSA BPA BPA 1 safe imit EESA BPA 10 20 5 FDA BPA FSANZ BPA EFSA FDA BPA FSANZ BPA
71. 1 5 A Draft BPA Report Gets Public Comment and Board Review NIEHS Environmental Factor 2008 7 NIEHS 25 http www nmiehs nih gov newsnewsletter critique cfm No 15 0 2008 4 NTP NIRHS A BPA MM brief NTP BSC Board of Seientific Counselors 6 11 12 BPA NTP E CERHR NTP Mike Shelby CERHR regulatory documents NTP
72. k 17g kg 128 g kg 1 g kg EFSA 50 g kg 1 50 1 100 EFSA AFSSA EFSA AI imits 5
73. NOAEL 5 mg kg bw NOAEL 2 000 27 000 83 NOAEL FDA FDA BPA f 2 5 ppm 1993 TDI 0 05 mg kg BPA
74. EFSA CEF AMU Statement of EFSA on a study assoclating bisphenol A with medical disorders Prepared by the Unit on food contact materials enzymes flavourings and processing aids CEE and the Unit on Assessment Methodology AMU 24 1072008 EFSA http wwwr efsa europa eu EEFSA efsa_locale 1178620758812 1211902145465 htm Ao 29 008 EFSA 9 29 JAMA A BPA Lang JAMA 2008 9 16 EFSA AFC 2006 BPA BPA TDI 0 05 mg kg EFSA BPA
75. subtle 4 E warning signs AFSSA EFSA AFSSA A BPA BPA AFSSA
76. A A A A Phenol 4 4 1 methylethylidene bis Bisphenol A http www ec gc ca substances ese eng challenge batch2 batch2_80 05 7_en pdf
77. CERHR BPA f 3 5 E BPA dismiss Michael Shelby if
78. 3 A i A quality quantity strength i A 1 2007 CERHR CERHR NTP A 1 1
79. Updated European Risk Assessment Report 4 4 Isopropylidenephenol Bisphenol A CAS Number 80 05 7 EINECS Number 201 245 8 Hinal Approved versnon awaiting for publication Environmental Addendum of February 2008 06 28 to be read in conjunction with published EU RAR of BPA 2003 for full details ECB http ecb rc 1t documents Existing Chemicals RISK_ASSESSMENT ADDENDUM bis phenola_add 325 pdf No 14 2 008 A 2003 RAR TT 2003 RAR http ecb jrc it es1s pgm esis_reponse php LANG en amp FROM LISTE EINECS amp ENTR EE 201 245 8 CAS 80 05 7 A Final RAR 2003 Addendum 2008
80. NTP National Toxicology Program FDA BPA TFDA NTP BPA FDA BPA reasonable steps BPA feeding cups BPA BPA FDA BFA obust FDA BPA
81. 4 2 A GLP A 1 A robust 1 pe E
82. 14 code of practicee A CRPA Canadian Environmental Protection Act 1 A A A A Mimnister s Remarks on Bisphenol A http wwwr hc sc gc ca ahc asc minist speeches
83. minimal 11 positive A sexual dimorphism some concern
84. 16 21 54 HDPE PRTRE 51 BPA 0 5z gL 17 13 BPA 0 50 8 82gm gL 1 5 g L BTFA TDI 25z g kg OE 60kg TDI i OCS PE 1 5L BPA 0 18 g kg 0 22
85. 2008 CMP BPA BPA 2009 H BPA 2009 2008 8 1 BPA E BPA Ph
86. AFSSA BPA 2010 3 2 BPFA 3 4 0 REPA A EPA to Scrutinize Environmental Impact of Bisphenol A 03 29 2010 http yosemite epa gov opa admpress nsf dOcf6618525a9efb85257359003fb69d 7811004 8d7f696d1852576f50054241a OpenDocument EPA No 08 7 EPA A BPA FDA Bisphenol A BPA Action Plan Summary EPA http wwwr epa gov oppt existingchemicals pubs actionplans bpa html
87. 2 A A Q A A A BfR A BfR RETFSA FDA A 0 6 mg kg 60kg A 0 6 mg kg 1 kg A TDI 60kg 8 mg
88. Opinion of the Scientific Panel on food additives flavourimngs processing alds and materials in contact with food AFO related to 2 2 BIS 4 HYDROXYPHENYL PROPANE Adopted date 29 11 2006 http wwwr efsa europa eu EFSA efsa_locale 1178620753812_1178620772817 htm No 3 2007 2 NTP Draft NTP Brief on BisphenolA April 14 2008 Peer Review Date June 11 2008 http cerhr niehs nih gov chemcals bisphenol BPADraftBriefVF 04 14 08 pdf No 9 2008 29 8 Draft Screening Assessment for Phenol 4 4 1 methylethylidene bis Bisphenol A 80 05 7 April 2008 http wwwr ec gc ca substances ese eng challenge batch2 batch2_80 05 7_en pdf No 9 2008 4 ECB Updated European Risk Assessment Report 4 4 Tsopropylidenephenol Bisphenol A Final Approved versnon awaiting for publication http ecb jrc it documents Existing Chemicals RISK_ASSESSMENT ADDENDUM bis phenola_add_325 pdf No 14 2008 5 Assessment of four studies on developmental neurotoxicity of bisphenol A http www vkm no eway defa
89. specific migration AFSSA BPA 4 3 A Survey of Bisphenol A in Canned Food Products from Canadnan Markets June 2010 http wwwr hc sc gc ca fn an pubs securit bpa_survey enquete can con eng php Health Canada No 13 7 A Canadian Environmental Protection Act CEPA H Domestic Substance List DSL 23 000 1 2008 10 18 A
90. E FSANZ BPA NE 5kg BPA ON Gdn lah mL 15 20 FSANZ 0 gt j RE H
91. 10 A Tm NO OO SGSK2O0 RTS 22 1 1 12 A 5 NTP A 2008 4 14 Draft NTP Brief on Bisphenol A April 14 2008 Peer Review Date June 11 2008 NTP CERHR F http cerhr niehs nih gov chemicals bisphenol BPADraftBriefVF 04 14 08 pdf No 9 008
92. BPA 2002 727EC 2002 8 6 BPA BPA BPA BPA 1980 BPA EFSA BPA EC SCF 2002 BPA 200
93. BfR FDA NN 1 TDI Ne A A BfR EFSA E A 2 EFSA A
94. BfR http www bfr bund de cm 279 selected questions_and answers on bisphenol a in fee ding_bottles_and_dummnes_for babies pdf No 22 009 A BRR A FAQ 2009 10 2 Q A A 2 2 4 Q A A Q A A A
95. 2 2 4 NN A Q A A A Q A A A A BfR
96. 7 38 SCF Im DU BPA SCF BPA Ms I BPA BPA BPA BPA BPA 4
97. 4 E AFC 2002 NOAEL 5 mg kg BPA robust BPA BPA a BPA robust 2 5 mg kg
98. BPA 10 20 5 FDA BPA FSANZ BPA EFSA FDA 40 BPA FSANZ BPA FSANZ
99. some concern 6 NTP BSC minimal concern EFSA No 16 2008 FDA No 18 2008 BPA 19 A Neue Studien zu Bisphenol A stellen die bisherige Risikobewertung nicht in Frage 19 09 2008 BfR http www bfr bund de cm 216 neue_studnen_zu_bisphenol_a stellen die_bisherige_ris 1kobewertung_nicht in frage pdf No 20 008 A BPA
100. 1 Q A A A TDI 0 01 mg kg A 3 A H Q A A A BfR
101. 2002 500 TDI 0 01 mg kg 2006 TDI 0 05 mg 5 100 kg 1 2 FDA 2008 1 NTP CERHR BPA FDA BPA 2 42 g kg 49 0 185r g kg f BPA NOAEL 2
102. BPA PK Gobust CERHR NTP A 5 FDA CERHR NTP hazard identifications note FDA GLP quality assurance statements FDA EFSA BPA
103. http cerhr niehs nih gov chemicals bisphenol MEETING SUMMARY _ BPA pdf 4 A Bisphenol A Evaluation NTP CERHR http cerhr niehs nih gov chemcals bisphenol bisphenol eval html No 25 09 A 2007 11 A A NTP CERHR Expert Panel Report on the Reproductive and Developmental Toxicity of Bisphenol A November 26 2007 http cerhr niehs nih gov chemicals bisphenol BPAHinalEPVF112607 pdf 1 2 8 4 5
104. http www nehs nih gov news releases 2008 bisphenol a cfm Ao 79 008 9 3 NTP A BPA BPA 32 BPA some concern NTP BPA NTP Associate Director John Bucher
105. A 2008 5 23 6 A Grovernment of Canada Takes Action on Another Chemical of Concern BisphenolA April 18 2008 http www hc sc gc ca ahc asc media nr cp 2008 2008_59 e html No 9 008 Clement Baird 4 18 A stakeholder A
106. A B some concern minimal concern minimal concern negligible concern A Some concern minimal concern A minimal concern negligible concern A NTP A
107. BPA BPA 40 7 BPA WHO TDI 0 05 mg BPA kg TDI NOAEL 100 5kg 80 57
108. BPA AFC U U U 10 1000 BPA AFC BPA
109. 6 13g g kg 7 50 g BPA 8 3 gykg 10 g BPA BPA 7g 10 g 2003 P EF 60 kg 0 16 g kg 0 04 0 08 p g kg E conservative EU BPA BPA 2002 OE E SCF I Ff RAR SCF 1 g kg
110. A http www nihs go jp hse food info foodinfonews index html 1j A 1 A Q amp A Ausgewahlte Fragen und Antworten zu Bisphenol A in Babyflaschchen 18 01 2006 BfR http www bfr bund de cd 7195 No 9 0 A A BfR A FAQ Q A A
111. Bisphenol A BPA and food packaging 19 January 2010 FSANZ http www foodstandards gov au educationalmaterialfactsheets factsheets2010 Dbisphe nolabpaandfood4701 cfm No 09 7 FSANZ A BPA FDA BPA FDA FSANZ FDA BPA FSANZ
112. 19 A A 60 2008 4 18 A A A
113. 2 16 A A A A
114. FDA BEA DHHS BPA FDA 52 FDA WHO FAO BPA Expert Consultation 1 27 November 2009 1 BPA INo 25 2009 p 18 http wwwr nhs go jp hse food mfo foodinfonews 2009 foodinfo200925 pdf 3 4 A
115. 34 EFSA TDI 0 05 mg kg BfR EFSA BPA TDI FDA BPA JAMA 1 PNAS 2 2 BfR Leranth 2 BPA BPA BPA BPA Lang et al 1 1 455 BPA BPA
116. BPA BPA Use of Polycarbonate Bottles and Urinary Bisphenol A Concentrations Jenny L Carwile Henry T Luu Laura S Bassett Daniel A Driscoll Caterina Yuan Jennifer Y Chang Xiaoyun Ye Antonna M Calafat and Karin B Michels doi 10 1289 ehp 0900604 available at http dx doi org Online 12 May 2009 26 A Grovernment of Canada Acts to Protect Newborns and Infants from Bisphenol A in Polycarbonate Plastic Baby Bottles June 26 2009 http wwwr hc sc gc ca ahc ascmedia nr cp 200972009_106 eng php No 14 2 009 A A
117. BPA unlikely EFSA BPA 1 hmit EFSA Oo BPA maximum daily safe BPA 10 20 ul 5 FSANZ EFSA 8 A Update on bisphenol A 25 04 2008 EFSA http www efsa europa eu EFSA efsa_locale 1178620753812_1178703466879 htm No 10 008 EFSA
118. robust data 48 NOAEL overall NOAEL 5 mg BPA kg 500 NOAEL BPA k BPA BPA OECD
119. 2 NTP 6 11 NTP some concern some concern FDA Hy s 24 1 No 11 2008 28 30 http www nhs go p hse food mfo foodimfonews 2008 foodinfo200811 pdf 2 INo 9 2008 24 25 http www nihs go p hse food mfo foodinfonews 2008 foodinfo200809 pdf 1 4 A
120. er negligible concern 13 minimal concern CERHR A
121. 6 5 5 1 A criteria A evaluate 640 mg kg day 1 250 mg kg day 450 mg kg bw day 600 mg kg bw day 450 mg kg day 600 mg kg day 148 mg kg day 600
122. BPA 5 2 4 BPA BPA NN BPA a 1 f E
123. A 15 0 08 4 30 gykg bw 0 1 0 50 4 30 pg kg bw 12 18 0 27 1 75 gkg bw 1 2
124. RSE BPA 6 E BPA E 4 E BPA BPA 1 f HI 1 H NOAEL 5 mg kg v Wz 6
125. 0 1 ng L A LC MS GC MS A 0 6 rg L A 19 8 g L NHANES III 394 20 59 A 95 5 18 gL 6 9 A lt 54 8 gyL 1 8 2 4 gyL A A 1 96g gyL A A A
126. 23 99 80 BPA 15 0 18 ng g 70 1 0 ng g 0 95 ng7g BPA 0 19 7 22 ng g 42 BPA NN 2008 BPA ei oe 2 A Survey of Bisphenol Ain Bottled Water Products July 2009 http wwwr hc sc gc ca fn an securit packag emball bpa bpa_survey enquete bot bou en g Dhp 2008 4
127. 3 6kg TDI 4 TDI 100 5 500 BPA 2002 SCF TDI 2 2006 10 BPA conservative TDI BPA E 4 ATFC 100 TDI 0
128. 1 2007 11 2 2008 4 NTP 3 2008 6 NTP 2008 NTP CERHR 1 No 18 2007 29 30 2 No 25 2007 41 46 3 No 9 2008 24 25 BPA NTP BSC Actions on the Draft NTP Brief on Bisphenol A by the NTP Board of Scientfic Counselors BSC June 11 2008 26 http ntp niehs nih gov files BSCactionsBPA 508 pdf NTP 4 BSC BSC some concern 12 0 some concern 10 2 BPA negl
129. 122 A BPA BPA BPA BPA BPA BPA E http wwwr hc sc gc ca fn an pubs securit bpa_survey enquete eng php 2008 8 6 7 122 122
130. 2 BfR BPA 2007 EFSA TDI 0 05 mg kg 2 BfR BPA
131. A Q A BfR A BfR A BfR Q A A
132. A BPA BPA BPA BPA BPA BPA umnlikely BPA EFSA BPA safe limit BPA safe level DT 20 safe limit
133. BFA 2009 3 5 No 6 No 12 2009 L BPA A BPA BPA 53 BPA BPA a BPA unlikely BPA BPA
134. Principal Deputy Commissioner Erank Torti NTP some concern minimal concern gerious concern FDA NTP FDA 5 concern 39 NTP negligible concern The NTP CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A September 2008 http cerhr niehs nih gov chemicals bisphenobisphenol pdf 5 2008 4 NTP draft brief
135. BPA 2 2002 AFC 2002 AFC AFC TDI TDI SR TDI a AFC BPA AFO TDI TDI
136. TDI 0 05 mg kg bw BPA BPA 2006 AFC BPA BPA AFC 2006 TDI EFSA NTP BPA 2 2008 3 2008 NTP
137. TFDA FDA 2008 4 14 NTP concerns 2008 4 FDA BPA 20 FDA BPA biological fate 2 BPA FDA FDA BPA FDA BPA
138. 05 mg kg 3 A 2 BisphenolA Second Expert Panel Meeting NTP CERHR http cerhr niehs nih gov chemicals bisphenol bisphenol mtg html No 18 00 NTP CERHR 2007 A 2 f 1 1 2007 3 5 7 2007 4 1 8 6 8 A j 1 A Draft Meeting Summary Expert Panel Evaluation of Bisphenol A http cerhr niehs nih gov chemicals bisphenoldraftBPA_MtgSumm080807 pdf
139. NTP NTP some concern NTP some concern CE RHR A E
140. 5 NZFSA TSANZ EFSA NZTFSA FSANZ BPA EFSA BPA 19
141. BPA BPA BPA 20 80 BPA BPA AFC BPA first pass metabolism BPA systemic availability E BPA BPA 4 BPA
142. TDI 0 05 mgykg bw ETFSA 2006 EU 20 E 1 mg kg RC 2003 2008 BPA BPA 4 E BPA equivalent BPA AFC NOAEL 100 1 EFSA 2006 1 j BPA EFSA 2006 BPA
143. BPA PC PC Qr BPA conservative 1 PC
144. 5 1 BfR Q A A A A A Q A A A A
145. NTP CERHR 2007 8 CERHR BPA FDA FDA BPA BPA 1 11g 1 7g FDA BPA FDA 2
146. 1 BPA 0 2 g 2 47 50 40C 5 1 BPA BfR AGES BPA 4 5kg 1 12 BPA TDI 1 BPA BPA BfR BPA BPA
147. A AFSSA Bisphenol A AFSSA recommends the development of new assessment methods 5 February 2010 AFSSA http wwwr afssa fr PM9100B610 htm 55 No 04 010 A BPA 40 FDA EFSA BPA BPA 2009 10 AFSSA AFSSA BPA
148. BPA EFSA BPA Stump 1 EFSA e A BPA EFSA H EFSA BPA 2010 5 E f 1 i 0 383 H Stump CEF CEF Draft Scientific
149. NTP 18 lt A A EFSA 2007 1 A TDI 0 05 mg kg bw EFSA A 9 A Bisphenol A May 2008 NZFSA http wwwr nzfsa govt nz7comnsumers chemicals toxnns additives bisphenol a htm No 10 008 Q amp A
150. lt 29 ng m3 0 41 lt 0 1 12 gyL 25 100 detectable 17 6u g g A A A lt 5 ug L 13 gyL 6 6 g L 6 8 7gL A 39 g kg
151. 2 3 FDA FDA TFDA FDA BPA FDA
152. EFSA updates advice on bisphenol 23 07 2008 EFSA http www efsa eu int EFSA efsa_locale 1178620753812_1211902017373 htm No 16 008 EFSA AFC A BPA 27 BPA 2006 EFSA 1 BPA TDI AFC BPA BPA AFC BPA BPA BPA 1 mg kg bw BPA AEC 2006
153. Draft Assessment of Bisphenol A for use in food contact applications Draft version 08 14 2008 http www fda gov ohrms dockets ac 08 briefing 2008 0038b1_01_ 02 FDA 20BPA 20 Draft 20Assessment pdf BPA BPA BPA BPA BPA NTP CERHR 3 BPA mixed results BPA 21 CFRS170 8G 4 BPA FDA
154. 1 some concern minimal concern minimal concern negligible concern 2 some concern minimal concern 3 negligible concern 2 gt minimal concern 5 5 1 f PBPK
155. A BPA 1 FDA Frank M Torti FDA Science Board head of Health Care Policy Barbara J McNeil BPA BPA FDA BPA FDA FDA Eschenbach FDA BPA CFSAN 2007 E BPA 2008 4 NTP BPA
156. discours 2008_04 18 e html 2006 12 200 A A A precautionary action A A 2
157. mg kg day 475 mg kg day A 0 01 0 2 mg kg day A 475 600 mg kg day 0 0024 mg kg day A 5 2 A
158. www nihs go p hse food info foodinfonews 2008 foodinfo200816 pdf 3 FDA No 18 2008 p 26 H A http www nihs go jp hse food info foodinfonews 2008 foodinfo200818 pdf 32 A Bisphenol A BPA and food packaging January 2010 FSANZ http www foodstandards gov au educationalmaterial factsheets factsheets2010 bisphe nolabpaandfood4688 cfm FSANZ RE I BN Austraian Competition and FSANZ FSANZ ACCC
159. 008 2008_167 eng php No 22 008 10 17 A 35 A A 18 A
160. 41 Bisphenol A A Oo http wwwr efsa europa eu en ceftopics topic bisphenol htm EFSA 59 No 09 7 2010 3 8 3 26 EFSA A BPA RU BFSA CEF 1 EU EU BPA BPA CEF BPA CEF F 2010 3 30
161. Opinion on a study investigating the neurodevelopmental toxicity of bisphenolA TDI 0 05 mg kg 4 2 AFSSA A 27 April 2010 http www afssa fr PM9100I510 htm AFSSA No 10 01 0 2010 1 29 AFSSA A 60 AFSSA BPA 769 BPA
162. announcesb4822 cfm PFSANZ No 15 7 Mark Butler Wesfarmers Coles K Mart Target Woolworths Big W Aldi BPA E 1 A BPA FDA BPA FDA BPA BPA Butler
163. igible consern 11 1 negligible consern 12 0 BPA minimal concern 11 0 1 BSC some concern minimal concern 7 4 1 some concern minimal concern 7 4 1 4 NTP 5 serious concern some concern minimal concern negligible concern concern 1 6 EFSA A
164. m g kg BPA 2008 3 4A Survey of Bisphenol Ain Canned Powdered Infant Formula Products July 2009 http wwwr hec sc gc ca fn arm pubs securit bpa_survey enquete pow pou eng php 2008 6 6 11 38 381 7 0 18 ng g A A Q amp A 2009 10 2 II 43 Selected questions and answers on bisphenol A in feeding bottles and dummies for babies Updated FAQs 2 October 2009
165. ult aspx pid 266 amp trg MainLeft_5419 amp 4698 5420 2 amp Ma inLeft_5419 5468 17924 0 5420 4 0 0 1 7 FDA A Meeting of the Bisphenol A Subcommittee of the Science Board to the Food and Drug Administration FDA http www fda gov oc advisory accalendar 2008 SciBrdSub91608 htm No 18 008 FDA Science Board BPA BPA 1 2 2008 9 16 DC http www fda gov ohrms dockets ac 08 briefing 2008 0038b1_01_00_index htm A 2008 8 14 30
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