アンジェス MG（4563）
Contents
1. HGF HOF HGF HGF 2001 2002 I I 20032. SR Inc SR Inc Shared Researchn SR Inc
3. Orphan Drug a i sh ared esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved j MG 4563 SR Research Report 2015 4 15 VI
4. 2 3 3 5 3 7 LAB LAB BIB 2013 R amp D 2006 2008 67 1 4696 ILTHESPKSA SS 19
5. 2015 3 H 20 2015 7 31 4 10 000 000 2
6. http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved MG 4563 SR Research Report 2015 4 15 d 2013 12 NF kB 2014 12 HGF
7. NF kB NF kB 2015 12 2017 2018 CIN 2016 CIN 2016 a P Sh ared esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All
8. 120 2007 6 40 HGF E Fontaine lE IM 4 2 8 12 12 HGF 70 4 19 27 30 896 4 13 p 0 014 FontainelV
9. KLab J GCA DIC
10. T a i sh ared Mesearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved j w MG 4563 SR Research Report 2015 4 15 KEDA T 900 22 6 AD NIL 2006 5
11. HGF HGF 2014 10 2018 2019 FAD HGF 300 400 HGF HGF 2007 2008 HGF PMDA
12. 166 2 a P Sh ared KMesearch http www sharedresearch jpD Copyright C 2013 Shared Research Inc All Rights Reserved a MG 4563 SR Research Report 2015 4 15 e 10 000 000 2014 12 18 68 2015 3 20 2015 7 31 929 6 1 1 250 0008 amp 2 6 1 75
13. CIN cervical intraepithelial neoplasia CIN FERARO CIN CIN BL 2013 4 BL CIN CIN HPV HPV HPV CIN
14. 2013 8 o 2014 4 VI ue
15. A 1 2013 5 1 989 BAA HGF 2013 2018 2014 4 491 1 2014 9 6 088 HGF TIL TR B SR 2014 12
16. 2003 9 HVJ E 2004 3 MG Allovectin 7 2006 5 KE DM Ra 2006 12 VI A Naglazyme GRE 2008 4 VI Naglazyme III FDA CR 2009 11 x SPA III FDA 2010 9 Fast Track
17. VI 30 1 10 B 1 2007 8 2008 3 2008 4 Sh atrodi escar ch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved z MG 4563 SR Research Report 2015 4 15 09 12 10 12 11 12 12 12 13 12 586 287 243 445 491 910 142 181 181 242 271 309 15 8 444 106 63 187 212 601
18. SR 2014 10 2014 12 4 98 MA aR MG 4563 SR Research Report 2015 4 15 37 4 2018 2018 SR 2019 2019 2020 C HGF 55
19. SR 5 2007 12 615 2008 12 2013 1 CRO Contract Research Organization HGCF MARRERO DT BAI 2006 12 1 920 2007 12 2013 12 274 HGF 2014 12 3 2014 12 3 4 2015 12 50 2
20. NF KB II 2015 12 2016 2017 2018 280 1 000 NF kB 4 NF kB PTA PTA
21. HGF 2013 3 370 2013 5 1 989 2014 9 J 6 088 a P Sh ared esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved ua MG 4563 SR Research Report 2015 4 15 2014 4 491 2013 3 400 HGF
22. 2012 1 02 j sh ared Kimni s http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved dO A MG 4563 SR Research Report 2015 4 15 2013 1 amp 2014 10 2014 10 1 26 2014 7 22 2014 9 30 65 249 21 140 FIR HA 6 088 2014 9 30 53 544 FIR 14 847 2014 9 2014 9
23. IT 2014 3 HGF
24. H SR HGF HGF 1984 HGF Hepatocyte Growth Factor 1984 1995 HGF HGF HGF Sh atrodi escar ch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved L MG 4563 SR Research Report 2015 4 15 RETER HGPAE N
25. 2003 5 HGF PRSETER O IL 2006 6 HGF TcPO HGF HGF HGF 2007 2010 HGF 2006
26. 2015 2 HGF 3 200 10 28 1906 21 50 99 HGF 2013 10 T I 2016 2015 2 HRE U
27. SR HGF HGF HGF NF kB CIN 2019 12 HGF 2019 12 HGF HGF
28. 2010 9 HGF 2011 12 2012 12 2012 12 HGF 2018 12 2010 2012 10 HGF 2013 3 370 2013 5 1 989 2013 8 HGF 2014 2 2014 9 6 08
29. HGF HGF HOF HGF HGF
30. 2014 5 TL NF kB 2013 3 15 2013 8 a i sh ared esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved j MG 4563
31. SR a i sh ared esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved ua MG 4563 SR Research Report 2015 4 15 d 2014 12 3 2014 12 3 282 28 0 222 18 7 60 69 5 2 330 116 5 109 21 29 633 237 95 1 709
32. 3 HGCF SW Strengths amp Weaknesses a P Sh ared esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved ua MG 4563 SR Research Report 2015 4 15 a 09 12 10 12 11 12 12 12 13 12 14 12 15 12 586 287 243 445 491 910 450 38 4 51 0 15 2 82 6 10 5 85 2 50 5 2 611 2 010 2 101 1 785 1 363 2 274 5 800 2 784 1 911 1 791 1 716 1 383 2 395 5 800 2 921 1 967 1 815 1 708 1 410 2 369 5 800 s 23 598 23 646 24 467 26 226 31 268 53 544 EPS 124 0 83 3 74 6 67 7 46 9 62 1 108 3 EPS DPS BPS 271 7 175 1 125 8 60 3 107 9 142 4
33. 2006 6 IL HGF HGF 2014 11 2017 HGF Weaknesses HGF
34. 2014 9 6 088 2014 12 6 017 2015 12 5 800 5 6 15 10 2015 2 2015 2 HGF 2015 2 HGF HGF
35. 3 2018 2014 9 4 HGF B HGF a i sh ared Mesearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved F a MG 4563 SR Research Report 2015 4 15 i 1 2015 2016
36. TOKAL
37. 6 500 15 HGF 3 4 2017 2018 HGF 80 HGF IL
38. 2016 1 2013 11 2014 A B a HGF 50 55 HGF No Option Poor Option 20 50 No option patients
39. HOF a i sh ared KMesearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved j w MG 4563 SR Research Report 2015 4 15 HGF NF kB NF kB NF kB NF kB PTA Percutaneous Transluminal Angioplasty NF kB
40. 2 1290 1 61 1 4796 1 2996 0 9890 0 91 0 8196 0 77 SR 2014 12 i P Shared esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved MG 4563 SR Research Report 2015 4 15 F MG 567 0085 7 155 4 072 643 3590 1999 12 17 H 2002 9 25 HP https www anges mg com index php 12 H IR IR https www anges mg com ir index php AREE IR IR E 03 5730 2641 a i sh ared KWeSGaT ch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved
41. 2014 9 5 9 30 9 29 2014 7 31 2014 8 1 100 9 332 198 9 134 9 134 2013 5 10 155 ADA 1 735 9 134 1 021
42. 5 047 3 053 1 576 355 2 295 6 017 5 935 4 143 2 635 1 342 3 305 7 594 61 72 62 45 23 28 954 633 1 050 770 506 508 212 157 142 103 70 54 7 162 5 004 3 889 2 260 3 904 8 184 49 98 60 67 42 207 g 515 488 417 331 218 116 649 716 601 507 345 423 17 15 15 15 17 15 15 26 649 716 618 522 361 449 i 6 513 4 288 3 271 1 739 3 544 7 734 z EUR 2 225 1 843 1 706 1 631 1 457 2 704 531 952 768 7 27 52 12 12 368 387 3 390 6 427 ROA l i i ROE 90 996 85 796 84 196 76 9 90 8 94 5 SR shared esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved
43. 2025 50 000 2019 HGF HGF NF kB HGF 2007 2008 PMDA Pharmaceuticals and Medical Devices Agency 2010 2013 8 2014 2 HGF 2019 2020 HGF
44. 439 367 2013 12 491 10 59 NF kB VI NF kB 271 12 3 212 13 3 a i sh ared KMesearch http www sharedresearch jpD Copyright C 2013 Shared Research Inc All Rights Reserved j w MG 4563 SR Research Report 2015 4 15 d 7 51 0 1 024
45. Poor option patients E 00d HGF 1 000 HGF 2014 4 HSCI Human Stem Cells Institute Neovasculgen ViroMed HGF VM202 PAD NV1FGF GED FGF1 e Neovasculgen 2011 9 The Russian Ministry of Healthcare and Social Development 2012 9
46. Y GFE PTA 147 360 57 9 170 15 5 15 9 476 328 437 337 NEDO 51 6 6
47. 601 WUZ 2015 12 HGF 2015 12 HGF NF kB 5 000 2014 12 Sh atrodi escar ch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved L MG 4563 SR Research Report 2015 4 15 i AHIRE HGF
48. 2 400 2 600 2 400 2 400 2 600 gt 2 400 VI 3 amp Sh atrodi escar ch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved 2 MG 4563
49. SR HGF 2015 2016 HGF 2016 HGF 2015 2 HGF 2012 10 HGF
50. NF kB HERIETH M ue z Te Per P1 2 CON RE AUT 27 HENAN T MUVAEXME SS CIN TEN H lx i r ug eil e E 534 se da HGF HGF NF kB CIN 2015 2 2 2014 12 2014 12 900 750 lt 850 Sh atrodi escar ch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved L MG 4563 SR Research Report 2015 4 15 2 400 2 600 2 400
51. 2009 1 2 2 1 CIN 3 10 2 7 E 17 E 70 9 CIN 3 CIN 2 CIN2 3 10 15 7 10
52. 98 2 339 E 128 3 694 0 7 34 2 274 1 363 Sh atrodi escar ch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved L MG 4563 SR Research Report 2015 4 15 d 2 395 1 383 NEDO 61 115 137 2 369 1 410 Sh atrodi escar ch http www sharedresearch jp Copyright C 2013 Shared Research
53. MG 4563 SR Research Report 2015 4 15 SR MG VOYAGE GROUP SBS
54. SR Inc SR Inc SR Inc SR Inc SR Inc 3 31 12 tBaht r 03 5834 8787 http www sharedresearch p Email info sharedresearch p a P Sh ared esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved j
55. 2015 2 2025 2025 500 1 2019 2015 12 2018 12 2015 12 2018 12 4 HGF NF kB I 2015 12 50 2016 12 2017 12 30 2018 12 HGF SR 2015 12 5 800
56. HGF 50 1 000 SR 30 4096 2015 12 450 5 800 2014 12 HGF NF KB SR HGF
57. 3 197 2 297 2 344 2 230 1 854 3 183 68 83 81 129 131 50 2 350 1 440 1 444 1 200 1 025 2 338 503 420 348 uL 247 309 1 062 315 348 374 274 1 194 779 775 819 901 699 693 104 123 123 12i 72 74 218 217 230 224 139 125 183 135 145 197 197 163 2 611 2 010 2 101 1 785 1 363 2 274 SR 09 12 10 12 11 12 12 12 13 12 289 102 42 159 35 89 97 90 132 151 53 83 91 110 120 5 26 113 B 2 50 SR 2014 12 33 99 66 1
58. 14 696 2012 12 100 64 HGF FDA 2013 3 SPA 2013 11 HGF NF kB NF kB 2011 3 2013 6 I
59. 2014 7 2014 7 22 8 1 9 22 32 403 900 32 403 900 1 288
60. MG 4563 SR Research Report 2015 4 15 x 2015 3 24 MG 25 HGF NEDO 25 69 2015 12 1 2015 12 2015 3 20 2015 3 20 EVO FUND
61. SR HGF 2010 9 2013 11 Sh ared esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved j MG 4563 SR Research Report 2015 4 15 d 2014 10 1 6 B 1 2015 2016
62. 20 5 36 81 0 1 210 27 7 67 25 8 344 816 55 4 326 11 6 27 16 1 035 632 998 629
63. VEGF Vascular Endothelial Growth Factor ViroMed Co Ltd HGF VM202 PAD Sh ared esearch z http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved MG 4563 SR Research Report 2015 4 15 d ViroMed 2014 LTHESPREREST MER T U Jc CEU CU VS HGF 1 4568 1 4508 2015 2 HGF 2015 2
64. 2025 Tik HGF NF kB 500 2025 2019 HGF HGF NF kB 2015 2 2015 2016 2017 2018 2019 HGF quus nhe SIRURI SATDUHBURKDRIS ET EU EU rk HGF P1 2 eM xy VAS URTE HARA NF kB is E F HAT AEN ES HE HES NF kB ntm Br iA 7 HHY XR dS mU
65. 779 6 90 EMLII MMMMM M M MMM M M M 1 j I 1 I 1 I 1 2001 12 2014 http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved MG 4563 SR Research Report 2015 4 15 d 4 TAE VI 2007300
66. VI HGF HGF 2012 10 3 184 21 2 151 15 1 HGF 920 255
67. NF kB PTA PTA 2016 31 5 NF kB NF KB 2013 3 2014 12 2016 FDA IND a P Sh ared esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved j MG 4563 SR Research Report 2015 4 15 1 2
68. I 2009 11 FDA SPA Special Protocol Assessment ICA BHES IIHR A B Ua 2010 9 PMDA HGF 2010 9 Fast Track a P Sh ared KMesearch http www sharedresearch jpD Copyright C 2013 Shared Research Inc All Rights Reserved j w MG 4563 SR Research Report 2015 4 15 Fast Track FDA i Uo d 2012 7 HGF 2014 10 1
69. 137 1 513 2 7 31 14 2 049 946 2 121 946 NEDO 61 96 118 13 2 091 972 2014 12 2 2014 12 2 174 44 6 137
70. Sh atrodi esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved MG 4563 SR Research Report 2015 4 15 i HGF 100 0 11 11 40 096 2 5 p 0 018 IT IV IV E RESEND d HGF 2008 3 HGF PMDA 2010 9
71. a i sh ared Mesearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved ua MG 4563 SR Research Report 2015 4 15 d NEDO 61 9 12 969 652 2014 12 1 2014 12 1 82 34 3 55 6 4 27 60 3 559 23 0 27 14 6
72. Shared Research Report 2015 4 15 MG 4563 sr_inquiries sharedresearch jp MG 4563 SR Research Report 2015 4 15 e E 3 aE S E a e E EA A A EA E E PR 4 1 5 MT E 5 jp 9 9 unosi oiu MER E OE 9 2015F I2 5 5 5 5 5
73. 6 017 2015 12 5 800 A 2016 12 2018 12 SR a P Sh ared esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved j Sh atrodi escar ch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved a MG 4563 SR Research Report 2015 4 15 2015 12 HGF HGF CIN 15 12 16 12 17 12 18 12 19 12 LL i EE E HGF iL E dm pa ul oe VE MT UTE mUkBU NEP DUE BLEER OLD LUI n Ro xe usd dL LR
74. SR Research Report 2015 4 15 13 12 14 12 14 12 3Q 2Q 126 189 76 100 83 92 107 628 101 1 900 84 390 14 2 3 8 21 3 34 3 51 4 40 596 528 396 454 493 390 517 559 651 1 120 853 21 7 25 5 19 3 2 4 23 0 32 0 187 5 65 1 328 305 313 417 476 560 1 013 225 2 400 4337 2202 2517 437 a437 562 122 274 2 400 i 367 286 319 438 439 530 1 122 279 2 400 SR 2014 12 2014 12 910 85 2 mazo Ere 309 13 7 601 183 1
75. a i sh ared Mesearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved j w MG 4563 SR Research Report 2015 4 15 100 100 1 021 10 SBI 3 90 2 21 1
76. 0 000 EVO FUND 2 750 33 2 717 1 2 6 Elir P uD 2015 2016 2017 2018 2019 3 12 H 1 673 214 200 211 NF kB 1 887 561 314 2015 2 H 26 2015 2 6 2014 12 2014 12 MG 2025 NE P Shared esearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved a MG 4563 SR Research Report 2015 4 15
77. 016 12 2017 12 30 2018 12 HGF SR 2012 12 3 2013 1 2012 12 901 2014 12 693 a i sh ared Mesearch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved j a MG 4563 SR Research Report 2015 4 15 SW Strengths Weaknesses Strengths HGF 2007
78. 1 1 cllc HM 12 Ll H 16 16 pzc gd E 18 I Iidem E E E E E DURUM MUERE PCM NEED EEUU 28 SW Strengths Weaknesses 4M memes 30 EO IDE PR T 1 E RR TEM 34 m o 34 A RE 2 ii 35 LINE UUT 37 ul 38 i sh ared 5 HLT ch http www sharedresearch jp Copyright C 2013 Shared Research Inc All Rights Reserved MG 4563 SR Research Report 2015 4 15 HGF 1999 HGF Da 2001 12 2015 2 2015 2 2025 2019
79. 22 15 FDA SPA 3 2014 10 500
80. 8 HGF 2018 12 a P Sh ared KMesearch http www sharedresearch jpD Copyright C 2013 Shared Research Inc All Rights Reserved ua MG 4563 SR Research Report 2015 4 15 HGF NF KB CIN Sem 1 7 MESSER HAJ HGF Ru UE EISE IUE Z pi ER ZH uc PTA ESPKESUER 2r Jb HAS TILES EI US SEDE BEBIDAS BRIT UU ARTE BUE C d DRE a EIBJ E UC St i CIN
81. Inc All Rights Reserved z MG 4563 SR Research Report 2015 4 15 2015 12 14 12 15 12 910 450 3 184 151 2 339 ROERO AEE 694 2 274 5 800 EE ES 2 395 5 800 ERE an 2 369 5 800 TUR aas SR 2015 12 450 5 800 VI MAALIERO HGF
82. Rights Reserved ua MG 4563 SR Research Report 2015 4 15 1999 HGF HGF DNA
83. SR Research Report 2015 4 15 wa 2000 8 HVJ E 1999 12 HGF RERNA GR 2001 10 2001 1 2001 10 HGF 2002 4 i HIRA GR XX CODES S SUIS 2002 6 du PUT tures OU S 8 TS E 2002 7 B TR FH OSZHBR Fin 053 E SISEZe HHBJCC 2002 9
84. els 1 000 SR 30740906 ERIS HGF HGF SR HGF HGF 2017 HGF 2013 10 I 1 2017 2015 2
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