JP 2009-527482 A 2009.7.30 10 (57)【要約】 サイトカイン投与を含む
Contents
1.2. N in SE A 1 r no 3 r3 cH NER a O I Sooo 2 r3 Sta I A p p Y 9 O I 9 QO Ol Ci
3. 152 HHHHHHHH JP 2009 527482 A 2009 7 30 60800760013 ls INTERNATIONAL SEARCH A CLASSIFICATION SUBJECT MATTER IPC 8 C12N 5 08 2008 04 USPC 435 366 i According to International Patent Classification IPC or to B FIELDS SEARCHED ntation searched classification system followed by classification symbols gt both national classification and IPC Minimum documei USPC 435 366 Documentation searched other than minimum documentation to the extent that such USPC 435 325 384 387 389 405 406 text search see terms below PubWEST PGPB USPT EPAB JPAB Google Scholar PubMed text search 598 terms below formation regeneration patient sar
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41. 520000 HHHHHHHHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHHHHHHHHH HHHHHHHHHHHHHHHHHHHHHHHHH 1000000000000000 III II II II II II B Transplanted HSC Eofarcted Usitaonn Sigaste HSC Migration e DEEN Ares Proliferation sad Cytoplasmic Proteins Hacker Proteine 43 GATAS 2 J P 2009 527482 2009 7 30
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48. FIGURE 32A E FIGURE 34A C 1908 PE LOG FIGURE 37 FIGURE 35 FIGURE 40 88 J P 2009 527482 2009 7 30 FIGURE 43 FIGURE 41 FIGURE 45A F FIGURE 44A F 89 J P 2009 527482 2009 7 30 FIGURE 464 D FIGURE 49A B 90 J P 2009 527482 2009 7 30 FIGURE 60AD FIGURE 58A F 91 J P 2009 527482 2009 7 30 Figure TOR i 1m Figure 10um Figure d G o dus Figure 7 m 92 J P 2009 527482 2009 7 30 Figure 79 A Figure 703 Figure 7QE H Figure 7a 8 c 3 93 J P 2009 527482 2009 7 30 10 VWF qdot 605 Figure 791 7 Figure 34 C
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60. 30 148 LI LI LI LI LI LI LI uH LI LI LI LI I LI LI I LI LI I LI LI I LI LI I LI LI II I H I LI LI LI LI LI I LI LI I LI LI I LI LI LI I LI LI I LI LI I LI LI I LI II LI I LI LI I LI LI LI I LI LI I LI LI I LI LI I LI II LI LI I LI LI L I L I L I L I L I I L I L I LI L I LI
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72. 009 7 30 EGFP Rh 144 JP 2009 527482 2009 7 30 2 mn mylimy SO 50 1 PEA 700 4 8 350 24 SO SO M MT SO M MET SO MI J P 2009 527482 2009 7 30 145 HHHHHH FH ON LIN IN 05 LIN IN OS LIN IN OS LIN TA 05 C 01 oas BH Gor 92s 3H ape dSAT LIN IK TNMOS SIN IN OS 146 J P 2009 527482 2009 7 30 00000 00 CSC Ki67 30 12h 24h 48h 12h 248 48h 147 J P 2009 527482 2009 7 30 200 100 210 2008 10 21 J P 2009 527482 2009 7
73. 1 Abott J D et al Stronal cell derived factor 1 alpha plays a critical role in stemcell recruitment to the heart after nyocardi al infarction but is not su ffi ci ent to induce homing in the absence of injury Circulation 110 3300 3305 2004 2 Aicher A et al Essential role of endothelial nitric oxide synthase for nob ilization of stemand progeni tor cells Nat Med 9 1370 1376 2003 3 Al varez Dol ado Pardal R Garci a Verdugo J M et al Fusion of bone narrow deri ved cells wth Purkinje neurons cardi onyocytes and hepatocytes Nature 2003 425 968 73 10 20 30 40 50 55 J P 2009 527482 2009 7 30 4 Amado L C Saliaris A P Schuleri K H et al Cardiac repair wth intranyocar di al injection of allogeneic mesenchymal stem cells after nyocardial infarction Proc Natl Acad Sci USA 2005 102 11474 9 5 Anerican Heart Association 2001 Heart and Stroke Statistical Update Dallas Tex American Heart Association 2000 6 Anerican Heart Association Heart Disease and Stroke Statistics 2005 Update URL aneri canheart or g downl oadabl heart 1105390918119HDSSt at s2005Updat e pdf 7 Anderson D J Stem cells and pattern formati on in the nervous system the possible versus the actual Neuron 2001 30 19 35 8 Anversa P amp Olivetti G Cellular basis of physiological and pathological m yocardial growh In Handbook of Physiology The Cardiovascul ar System The Hear t
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77. JP 2009 527482 A 2009 7 30 19 JP A 11 2009 527482 P2009 527482A 43 21 7 30 2009 7 30 51 Int CI AG1K 35 4 2006 01 A61K 35 34 4BO65 A61P 9 0 2006 01 AG61P 9 00 4C087 AG1P 9 10 20501 A61P 910 101 A61P 9 12 2006 01 A61P 9 12 A61P 29 0 2006 01 AGIP 29 00 101 BERK ARR RR 153 R BRACES 21 2008 555409 P2008 555409 71 500296804 86 22 19 2 15 2007 2 15 85 20 10 8 2008 10 8 NEW YORK MEDICAL CO 86 PCT US2007 004287 LLEGE 87 w02007 100530 10595 87 19 9 7 2007 9 31 11 357 898 74 100079108 32 18 2 16 2006 2 16 33 US 74 100093861 REF XE RA 74 100109346 XE ME 54
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85. igure 19 Figure IR Figure QO Figure at 81 J P 2009 527482 2009 7 30 FIGURE 22 FIGURE 2110 J P 2009 527482 2009 7 30 82 HAEC PANO TIE MANDA He FUND FIGURE 24A D 83 J P 2009 527482 2009 7 30 FIGURE 264 F FIGURE 25 FIGURE 26G J GURE 26K N J P 2009 527482 2009 7 30 84 FIGURE 28A B MIND ANDIA FIGURE 28G H J P 2009 527482 2009 7 30 85 HIS WADA 9 30 CCYOE TANDA 86 J P 2009 527482 2009 7 30 FIGURE 31A C FIGURE 31D E FIGURE 31F N FIGURE 310 P 87 J P 2009 527482 2009 7 30
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97. um media transferring Insulln selenite uridine Inosina 1 C DOCUMENTS CONSIDERED TO BE RELEVANT Citation of document with indication where appropriate of the relevant passages 0003 0005 0006 0045 10046 0049 0069 0152 0184 0197 40189 0274 0276 0307 US 2003 0105015 A1 GILBERTSON etai 5 June 2003 05 06 2003 para 0053 retrieved on Sept 7 2008 Retrlaved from the Internet URL http www roche applied sclence com pack insert 1074547a pdf gt para 6 filing cited to establish the publication date of another citation or other Special reason as specified published prior to the international filing date but later than gn document member of the seme Date of the actual completion of the intemational search 08 September 2008 08 09 2008 _ 15 SEP 2008 Authorized officer Name and mailing address of the ISA US Mail Stop PCT Attn ISA US Commissioner for Patents P O Box 1450 Alexandria Virginia 22313 1450 Facsimile No 571 273 3201 Form PCT ISA 210 second sheet fAnril 2607 PCT Halpdesk 571 272 4300 PCY OSP 874 272 7774 International application No PCTAUS 07 04287 documents are included in the fields searched Electronic data base consulted during the international search name of data base and where practicable search terms used Search terme Cardiac
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