KITASATO UNIVERSITY EAST HOSPITAL
Contents
1.2. 1 2 3
3. Ax a CU
4. HIV HIV
5. RR 35 145 25 84 26 11 25 PMDA PMDA
6. 8 ew 0 H
7. CYP3A4 1 1 5 CYP3A4 Cmin Cmax AUC24 89 69 80 CYP3A4 CYP3A4
8. 2 DRUG NEWS DRUG NEWS 2008 2619 252 0380 2 1 1 10
9. BB CT S100 HD A240 HD
10. gt lt 22
11. gt 1 375mg m 1 4 1 500ng 1 25mg 103 HH008E7 700 2 100mg 4
12. 3 0 3 4 23 4 26 7 8 500 25 17 7 2 2 gt 6 26 5 AST GOT ALT GPT 3 4 CF 23 4 26 7
13. CYP3A4 HTYV HIV
14. WEB 4 ICU LAN
15. eGFR 1 3mg dL 1 2mg dL 1 0mg dL 3 4 GS w RN 00 GLP 1 SGLT2 MM EAN NAR 2
16. uw Rr 1 50mg 1 200mg 1 1 2 1 2 1 50mg 1 1 2 1 2 5 1 200mg 1 2 6 1 300ng 1 2 7
17. 4 X C XX CT
18. 5 HT3 NK1 CYP3A4 5 4
19. 12 1 100mg 1 100 200mg 1 1 2 1 1 100ng 1 400ng 1 1 2 2 1 25mg 2 1 25mg 1 1 12 1 25 50mg 100 200mg 1 2 1 Cl 2 1 100mg 1 2 1 2 1 100mg 0 PIT
20. i i 9 6 HHV 6 A ER
21. 1 i lt 3 A 2 EE Hi SGLT2 1L
22. 3 1 gt Gastric antral vascular ect asia GAVE
23. Oo 2 3 4 CU X
24. Cmin AUC 92 48 CYP3A4 8
25. 2 1 25mg 2 1 25mg 1 1 5 1 50mg 1 1 2 6 1 100mg 1 1 2 1
26. a ES CYP2C9 CYP3A4 GLP 1 J g Os
27. 5 O O 2 3 ta i
28. 1 2 1 1 2mg kg 1 5 15mg kg 1 2 1 400mg 2 1 25mg 100mg 2 1 25mg 1 1 2 1 50mng 1 1 2 5 1 100mg 1 1 2 6 1 200mg 1 2 1 1 100ng 1 400mng 1 1 2
29. 1 300 400mg 1 2 CD 1 1 100mg 1 400mg 1 2 2 1 2 1 2 1
30. AKG E EHH
31. 1 1 RE o OE 2 H SGLT2 L
32. w TNF B HBs HBc HBs B B
33. 1 PHS PHS 2 LAN LAN LAN 3 RFID ZigBee Bluetooth RFID
34. 2 1 2ng 5mg 25mg 100mg 2 1 0 15mg kg 1 1 2 1 0 3mg kg 1 1 1 2 1 0 3mg kg 1 1 5mg kg 1 1 3mg kg 1 2 1 200mng 2 1 0 6mg kg 1 2 2 1 1 2mg kg 1 2
35. 1 1 1 T 7 0 AST 500U L ALT 500U L 10mg dL 197 25 3 22 6 1 26 2 S 1 25mg 100mg 2 1 25mg 1 1 2 1 50mg 1 1 5 1 100mg 1 1 2
36. PMDA PMDA 3 3 26 11 25 100 8916 100 0013 1 2 2 3 3 2 03 3508 4364 0120 395 390 anzensei hokoku estrigwmhlw go jp anzensei hoko ku pmda go jp e Gov http shinseie gov go jp menu
37. ti Web ra E 5 A 1
38. D DRUG NEWS No 317 URL http www info pmda go jp iyaku_anzen file PMDSI317 pdf 26 10 28 1 CE i 5 ris 1 ni
39. KITIASATO UNIVERSITY EAST HOSPITAL DRUG NEWS Vo1 25 19 2014 11 2008 2619 o oo No 317 8 i 2 E 3 5 1 S100 HD A240 H
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