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1. 06 FRE DI MR2. E 400 700nm 6 5nm 3nm 5 1 10 2 5C 50C 130 220rpm 10rpm 10 30mm PID Bio Microplate Reader for Windows Windows PC W335xD439xH165mm 20kg 200W AC100V 50 60Hz 3A 1 120 130 220rpm 151205
3. 1 Perrirmon Mi 30 Cosmo Bio News No 73 RNA 50 mRNA mRNA APC
4. 4 SL 1 o DE TEL 03 5632 9610 FAX 03 5632 9619 Cosmo Bio News No 73 25 fo HH MHNT S Fa YYA an TG SL 1 TOPICS E R T5C 50C
5. SA ELISA ISingle Analyte ELISArrayrV 1 MR ELISArrayTW TEL 03 5632 9616 FAX 03 5632 9614 E mail jutaku amp cosmobio co jp 14 Cosmo Bio News No 73 rannan mr SED BACS kAtta ORRE 4C 20C M 70TIRT BERNER 196C vat FlowCytomix Multiplex 96 vi R 0 1 6 1 1
6. 96 Bender Medsystems GmbH a Vacuum Manifold BMS497FF 1 unit 120 000 Q 2009 4 1 150 000 FlowCytomix Comboplex Gimplex Basic Simplex 20
7. ES ES On vitro BMSC MSC 8 Cosmo Bio News No 73 R amp D NM InC JESS EE z kit Y62 000 eo SC005 1 kit 68 000 SC011 1 kit Y 89 000 SC013 1 kit Y 89 000 SC001B 1 kit Y 208 000 SC004 1 kit 104 000 SC006 1 kit 73 000 s amp kan P10 16 O Methyl Profiler PCR
8. ELISA ELISpot Fluorokine 009 a 4 100 E 2009 008 siRNA
9. 99 shRNA R shRNA 19 5nt 3 5 shRNA siHNA Transfection Heady RT PCR Mg8 shRNA shRNA
10. BMS812FF PE 96 1 25 PE BMS81 BFF CD Win Mac 96 Simplex CD S00 http www bendermedsystems com possible combinations 43
11. Joanne Chory Science Signaling 4 Jupiter 2 Images Y Related Resources Editorial Guides E M Adler J F Foley N R Gough L B Ray 2007 Signaling breakthroughs of the year Sci Signal T eg1 2008 E M Adler N R Gough L B Ray 2006 Signaling breakthroughs of the year Sci STKE 2007 eg 1 2007 E M Adler N R Gough L B Ray 2005 Signaling breakthroughs of the year Sci STKE 2006 eg 1 2006 N R Gough L B Ray 2004 Signaling breakthroughs of the year Sci STKE 2005 eg 1 2005 M Adler N R Gough L B Ray 2003 Signaling breakthroughs of the
12. Fruman 2
13. 2008 http www cosmobio co jp company tools cbtools top asp 6 2009 5 15 J 8 P Sen O Ga X 2 Kr 2009 3 27 3 29 36 3 2 3 4 96 SS 5 1 5 9 EE NE RSD 009 R amp D
14. Gomez Roldan Umehara 4 699 TOM 5 198980 10
15. GTPase Has Snyder HRHas LTP 3 Svoboda AMPA Heine 22 2 K 1 min 2 min 4 min 7 min
16. Perrimon Christofk M2 9 TOR target of rapamycin TOR TOR TOR 2003 Fruman 008
17. UV Hn NN CometAssay CometAssay CometAssay CometAssay Silver Kit CometAssay HT Sample Kit CometAssay Kit 96 wells 2 20 896 FY UINLLERE ee 2 20 gt HE 1 CometAssay Trevigen Inc TRV 1 kit 4250 050 ES Trevigen Inc TRV 4250 050 K 1 kit Y 46 000 4251 050 K 50 test 63 000 4252 040 K 40 test Y 46 000 4253 096 K 96 well Y 46 000 Cosmo Bio News No 73 D A F JU J S Pa NE NM FKA o DE t ee NTN EVERETT mi Pa MitoPT 3 PIY RUP BEE ETR v h TQ aA ii MitoPTTM JC 1
18. EPRA Utt EERMonosiga brevicollis 2 Manning Pincus PTP SHg SV ET EPTBRAXAVEDFENRESNE NY N V Ta Src mA FANNY WV N SH2 ANA PE PTP n EEDA M EFS 7 HERD H lgFOY DVDER TE NYE ml ei Hi 1 AMonosjgg reproduced from 1 1 with permission lg copyright 2008 National Academy of Sciences USA EZ i ER Solomon Snyder Jeffrey Ehmsen Bindu Paul Michael Koldobskiy 3
19. iPS IiPS 1 ES iPS ES IPS ES IPS ES
20. T 2 TOR AMP AMPK Perrimon AMPK 24 AMPK mA Cosmo Bio News No 73 31 2008
21. 19 lsalan 1 Tony Hunter 1 0 3 Hunter
22. RNAiBoost V Reagent siRNA shRNA RNAIBoost mRNA siHNA miRNA En N RNAiBoost Reagent Kit miRNA TOPICS S Large RNA MRMIMELEN OOA E R Rapid 10 e255 RNA small RNA miRNA siRNA tRNA 5S rRNA small RNA RNA DNA
23. N NubG 1 C Cub NubG DUALmembran starter kit G3 1 pBT3 N pBT3 SUC pBT3 STE 5 g ENES DEE l pPR3 N pPR3 N pPR3 N 5 ug Am cDNA 2 60 ug 2 a pOst1 Nubl 5 ug pe FF pTSU2 APP NEMO CAR
24. P26 gt Cosmo Bio News No 73 9 z 7E JU S Pa OA NIMI en V NT FKA o DE Methyl Profilerrm PCH CDG DNA PCR low throughput DNA R OE I in
25. 2 Gr GR A t einen http why mods jp INNO LiPA HPV Extra 18 HITS 26 EF ES iPS ES iPS ES iPS Mo ES
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27. 2Pwwet pa nzpwTppsnEpTA A 3 IN ES 0000000000000000000000000000000000000000000000000000000000000000000000000000000000060 EEE 9 135C 2 eweckesmmoses iPS ES sets j T 3 4 lt Mike ak EA 5 5 REC LESREC A A 4 ES Tp 250 ml Y19 600 RCHEMD001 500 m Y 29 400 ZRHESMEA I1 4 U Zt ReproFF RCHEMD003 100 mg 12 800 ES RCHETP002 30 ml 15 000 ES RCHEFM001 25 me Y 16 500 SL10 RCHEFC002 5 vial 1x105 cells vial Y15 000 ES
28. 2009 Knowledge Environment Editorial Guide 1 Science Signaling ihs 5008 Joanne Chory David Frurman USA Tony Hunter USA fi F ARE FE Randall Moon Norbert Perrimon Harvard Medical School USA
29. 8 208 QUO GET 2g009 1 5 Quo 500 amp SR 4 000 gc T 009 CDER
30. Fruman CD19 BCR CD19 CD 1 B 2 CDER CD 9 B Fruman E 3 0H PIGK Fruman
31. 1H NMR JA Bon 1H NMH o m DSCS p mE Fi Ak E R 0SCS 4 My 95 MN FE a SERVA Ends GmbH SER Over Sulfated Chondroitin Sulfate OSCS Standard 31 B 2 Re Y 85 000 31254 10 mg 24 Cosmo Bio News No 73 md 4C 0C 70C BERNER 196C F VER N j 7 wx NERESE GM EE ET nanm
32. _ FOLCH lt OFBBE DATE I OFRE TERRE DATE 1g gg 1g ug F SATHE TO TG je FC PL lt 3 n 5 EE I FOLCH J et al 1957 J Biol Chem 497 509 120 lt lt 60 Wo nas aa lt 20 3 4 100 fo Er a lt 6 1 2 3 a z o 5 RASER RARE MENA E i LEE T EG lt EHM 2 100 mg gt nn MFIKGRE GSE EA 08 M en sj lt SKY nel ii 15 ae r RETTENE y o 1 12 11 200 13 24 Y10 600 E e 25 9 800 A a E 5 F 1 2 3 1 2 3 lt JJ P
33. MBL L Ficolin H Ficolin MBL SH Ficolin MASP H Ficolin H Ficolin MASP MASP C4 C OTMBEE C3 C 4bC2b se E HH Ficolin 96 5 Hycult o hd B V SH E E EET E ME a E MRI H Ficolin ELISA kit 3 ng m 3 500 EE 100 NE K340 1 kit 2x96 well Y144 000 Hycult Gd ES B V SHG X EE VEE JE EM VERT VE NN EI LE P L Ficolin ELISA kit 16 ng ml 16 1 000 E 100 en HK336 1 kit 2x96 well v188 000 NEW HIV 1 p24 ELISA pl i lt a i HIV 1 p24 ELISA
34. 5 Da rch ES 6 2 0 0 9 ES FBS 6 7 Platinum 7 NE en StemTAG 96 8 8 II 2008 30 33 E Methyl Profiler PCR amp 10 17 E INNO LiPA HPV Extra 18 TrueORF cDNA 22 25 HITS 26 VIF IME Methyl Profiler PCR amp 10 RiboAmp Plus amp RiboAmp HS Plus RNA 18 CytoSelect 24 Well 11 19 CometAssay 11 RNAiBoost Reagent 20 MitoPT 12 miRNA 20 1 RE pk
35. eds Technologies LLC MitoPT TMRE red fluorescence 91 5 E 27 000 eMitoPT TMRE CCCP TMRE MitoPT TMRM red fluorescence 9104 100 test 27 000 MitoPT TMRM CCCP TMRM 12 Cosmo Bio News No 73 mr 4C 50C 70C BERNER 196C NEW PAPP in vivo PARPHEBFOEVENETSV 7 PEMRNDAR ESKE RETT 5 ADP PAHP NAD ADP PAR OD PARP PAR PARP PARP PA
36. m2 ES ReproFF EEREN l ES bFGF A B 8 l ES KhES 1 KhES 3 8 1 masrees Oot 9 4 O 7 JJ JL ES 00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000 TR iPS ES ES ES I
37. 1 1 2 3 4 TI 9 Gen oe g s ALP 3 lt lt lt 60 min 30 min 60 min He 1 DNA 8S 3 DNA 4 _INNOGENETICS N V TA 1 kit 20 test Y 218 000 RiboAmp Plus amp RiboAmp HS Plus RNA tF v I NEW RiboAmp Plus RNA RHNA 1ng total RNA mRHNA 1 I 1 000 1 000 000 mRNA 2 qRT PCR
38. AA 4C 50C 70C FERKER 196087 D DNA 10 5 1 DNA DNA RHNA 1 DNA R
39. DNA Ds G A T 3 4 Aeg si Edo Th 1 DNA En R Psoralen a 2 Hypoxypro
40. OD Graph 4 96 Bio Microplate Reader for Windows E HiTS nm nm FT40 400 FT63 532 FT41 405 FT64 535 FT42 410 FT65 540 FT43 415 FT66 546 FT44 420 FT67 550 FT45 430 FT68 568 FT46 436 FT69 580 FT47 442 FT70 589 FT48 450 FT71 600 FT49 455 FT72 610 FT50 458 FT73 620 FT51 467 FT74 630 FT52 470 FT75 632 FT53 480 FT76 636 FT54 486 FT77 640 FT55 488 FT78 647 FT56 492 FT79 650 FT57 500 FT80 656 FT58 505 FT81 671 FT59 508 FT82 676 FT60 510 FT83 690 FT61 515 FT84 694 FT62 520 FT85 730 45 0001 1 1nm 40T FT40 301 HITS S2 1 set Y1 800 000 vol 30 vol 3 1 5555 er ME ES XAMR gt BE Hr 2 4 om r
41. C 13 DUALmembrane 21 Multi Analyte Profiler ELISArray TrueORF cDNA 22 ELISA 14 PathProfilerW ELISA 23 FlowCytomix Multiplex 15 Alleeustrious 23 n a pir pe H Ficolin ELISA 16 HiLyte Fluor 24 PE T R o HIV 1 p24 ELISA 16 OSCS 24 v A i EE 17 25 9 17
42. Yamanaka Cell 131 1 12 2007 Cosmo Bio News No 73 E S Pa ANY NT EHKK o DE Proteome Profiler 15 _ 2 gd 20000 7 1 5 je a ami TEES 40 000 15 B l 30 000 M aooo gr E 10000 HRP EELEE
43. Basic 35 000 kit Cosmo Bio News No 73 15 7 F JU J S Pa ANM NM FKA o 1 i uk Ficoln ELISAF v IN L Ficolin JETA FEN M Ficolin H Ficolin 3 SHFicolinld NBR Sug mMDRETEAFNTUNFI Hakata antigen Ficolin 3 Ficolin HFicolin 3 C DASR RRDREEMUES O o a N GIlcNAc N re ZJN GalNAo vr ES Ficolin
44. gt lt ladies 5 or ES ENE 2 DORF TG 100 mg 3 4 FC J PL GATE N 3 100mg 4 HA 4 2 1 12 Y11 200 13 200 13 200 14 600 13 24 10 600 12 600 12 600 13 800 25 9 800 11 800 11 800 13 000 TC amp TG TC amp FC TCS PL
45. 2 N C P NN MAA AA WT WIT MM Be RE p HA MTN e3 _ cDNA 1 meai VW b GERF vb lt Transcription OFF Transerption OFF Transcription ON DUALmembrane El 6 Bait Prey Yeast starter kit Y643 000 DUALmembrane starter kit v477 000 A C Cub CONA Dany x400 000 LexA VP16 B
46. TM3 RiboAmp Plus HNA RT PCR ne 3 aRHNA 3 ready for labeling MEF 1a 3 000 cell187bp pr 3md round amplification M GAPDH 300 3 000 cell 357bp MPP 1 300 cell 1 74bp M Lane1 MEF 1a Lane2 M GAPDH Lane3 MPP1 RiboAmp RNA Plus RNA MDS Analytical Technologies Inc RiboAmp Plus KIT0521 1 kit 6 rxn 147 000 9 RiboAmp HS Plus Q 18 Cosmo Bio News No 73 KIT0525 1 kit 6 rxn 187 500 rannas dd SED BACS kne AmC ORRE O4CRF 0C 70C BERNER 196C NEW siRNA ER 99 siRNA O3 775 9996 P
47. 1 96 000 TPP BHFEIETT AEE FE 1 Bender Medsystems GmbH Th1 Th2 11plex FlowCytomix Human IFN y IL 1 IL 2 IL 4 IL 5 IL 6 IL 8 IL 10 IL 12 TNF TNF BMS810FF 96 test 265 000 Adhesion 6plex FlowCytomix Human SsE selectin SICAM 1 sICAM 3 sP Selectin SsVCAM 1 sPECAM 1 BMS812FF 96 test 150 000 Cardio Vascular 6Plex FlowCytomix Human CD40L P selectin t PA MCP 1 IL 6 IL 8 BMS811 2FF 96 test Y150 000 Chemokine 6plex Flowcytomix Human IL 8 G CSF MCP 1 MIG MIP 1 MIP 1 8 BMS813FF 96 test 160 000 Obesity 9plex FlowCytomix Human SsCD40L sICAM 1 IL 6 Leptin MCP 1 MPO OPG Resistin sTNF R BMS816FF 96 test 245 000 Th1 Th2 10plex FlowCytomix Mouse GM CSF IFN y IL 1 IL 2 IL 4 IL 5 IL 6 IL 10 IL 17 TNF BMS820FF 96 test Y250 000 Chemokne 6plex Flowcytomix Mouse MCP 3 MCP 1 RANTAES GM CSF MIP 1 MIP 1 8 BMS821FF 96 test 160 000 Cytokines 6plex FlowCytomix Rat GM CSF IFN y IL 1 IL 4 MCP 1 TNF BMS825FF 96 test 150 000 AIAOSA
48. Cosmo Bio News No 73 23 TG SL 1 A o ES H EHISHJUNV S Fa YYA NM FAK o ES HiLyte Fluor HiLyte Fluor HiLyte Fluor 594 NEW HiLyte Fluor 647 HiLyte FIuorTM 680 or allophycocyanin APC HiLyte FluorTM 750 753nm 7 20 750nm E R GHiLyte Fluor 488 FITC pH10 FITC 75 LL Ai TOEA RE FORMI C 9 E GHiLyte Fluor 555 CyG Cy3 GHiLyte Fluor 594 TexassRed GHiLyte Fluor 647 CyG
49. ES ES MEF ES FBS FBS Qualified for Human Embryonic Stem Cells 6 Cosmo Bio News No 73 ES a ES pr FACS it Industries Ltd fe 04 002 1A 500 pr Y 30 000 FME IT TIGER KEN ES I Hikichi T et al 2007 Stem Cells 25 46 53 EE IS Bi RAA EVERT I ORDESA I MED RGI MCI ER MIDDIAFIEIS NTUFTI 9 80 OMA TAARA 4C 20C 70C
50. RNA HNA RNA OTER GH Vy I77 MLargeRNA hn N microRNA Purification Kit RINA miRNA siHNA RHNA Hn Total RNA purification kit 20 Cosmo Bio News No 73 siRNA R siRNA RNAi miRNA siRNA shRNA miRNA RHNA RNAiBoost Reagent A 100x RNAiBoost Reagent B 100x Cell OS Inc mu RNAI n 20 rxn 50 000 RNAI 201 100 rxn 125 000
51. 6 15 249 5 50 0C 0 1 x1 46 1 Bio Micoplate Reader For Windows x1 Windows Q read R En IN 26 Cosmo Bio News No 73 HITS 96 297507 1 HITS M3 HiTS
52. Solomon Snyder Johns Hopkins University USA 2008 Norbert Perrimon Zhu Zhu
53. y BDR CERI N z Er F E Mr ee hours i TG ga 1 0 5L 60 COz 596 3 COs 0 5 2 9 CO gt 0 5L 0 5L 0 5L CO gt 2 5L 2 5L CF 63 CF 111 CF 11
54. pTUNE ORF E R 25 000 1 000 ready High Fidelity cDNA Precision Shuttlerw 1 His Myc HA WWpTUNE 0RHF IPTG MIDTRE IS R ER TE FI W ORF C DDK His MyCc
55. SA c myc 9 p RA Receptor SA SABiosciences Focus on Your Pathway SA bee ee TRAE INADA OER OF LER AE 2009 3 1 OF 135 0016 2 2 20 URL http www cosmobio co jp Oo TEL 03 5632 9610 FAX 03 5632 9619 TEL 03 5632 9620
56. 100 Cosmo Bio News No 73 27 PESEE CEEE 2 PDE PGI 12753 1 AP 150 u 68 000 G5b Protein LSP LS C50023 100 100 ug 91 000 4 Amino Biphenyl DNA NUR MO25015 100 u 104 000 GABRG1 PGI 12871 1 AP 150 u2 68 000 A GAGE1 PGI 12795 1 AP 150 u2 68 000 ACSBG1 SCB SC 130090 100 ug 51 000 GLS PGI 12855 1 AP 150 u2 68 000 Actin y 2 LSP LS C49418 100 100p 91 000 Glutamine rich 1 LSP LS C32174 50 50 u8 87 000 ADAMTS12 LSP LS B1131 50 50 ug Y62 000 Glycated human hemoglobin HbA1c AIC 2 GHH 200 ug 93 000 AGP CL CLAS01 015 200 ul 100 000 GOLGA1 PGI 12640 1 AP 150 u2 68 000 ALG 1 PGI 12872 1 AP 150 ul 68 000 GPR 146 LSP LS A1989 50 50 ug 62 000 AMPD1 LSP LS B1806 50 50 ug 62 000 GRPEL 1 PGI 12720 1 AP 150 u2 68 000 APE 2 SCB SC 130106 100 ug Y51 000 H Aquaporin AtSIP1 1 COP COP 080031 100 u 30 000 HEBP2 PGI 12706 1 AP 150 u2 68 000 Aquaporin AtSIP2 1 COP COP 080032 100 u 30 000 HEP 1 3 17 BLG 30 NT 154 50 ug 123 000 Aquaporin PIP1 1
57. WDMEM 5X 10X GCyQuant GR Dye StemTAG AP A HATHA AP AP DESA E EHRAM ES Esman DO 5 BLEA D 2 iv77 AA yOuanbg S R D ETE EG TF RE Edut 88 ES R BT TEA D FN W AEE O EA ES Ekom z ES HATTEM u HEEEL det CyQuanB GR Dye 0M0 mi ES D8 KAL E ES REE Cell Biolabs Inc R StemTAG 96 Well Stem Cell Colony Formation HE sen 24 TE 148 000 H CBA 325 5 5x96 assay 622 000 Neurosphere
58. Anaspec Inc ASI m Ex Em nm lelo AV I C D 81161 81162 81163 81164 HiLyte Fluor 488 502 527 81160 109 000 10 mg 59 000 5 mg 39 000 1 mg 39 000 1 mg 39 000 1 mg HiLyte Fluor 555 551 567 81250 81251 81252 81253 81254 119 000 5 mg 39 000 1 mg 49 000 1 mg 49 000 1 mg 49 000 1 mg HiLyte Fluor 594 593 616 81271 81272 1 81273 81274 81275 109 000 10 mg 23 000 1 mg Y27 000 1 mg 27 000 1 mg 27 000 1 mg HiLyte Fluor 647 649 674 81255 81256 81257 81258 81259 119 000 5 mg 29 000 1 mg Y39 000 1 mg 39 000 1 mg 39 000 1 mg HiLyte Fluor 680 678 699 81260 81261 81262 81263 81264 119 000 5 mg 39 000 1 mg 39 000 1 mg 39 000 1 mg 39 000 1 mg HiLyte Fluor 750 751 779 81265 81266 81267 81268 119 000 5 mg 39 000 1 mg Y39 000 1 mg 39 000 1 mg Q FELETTI NEW z OSCS 0SCS SERVA Gsystem suitability test SST OSCS FDA EDQM
59. C RCHEFC001 5 vial 3x10 cells vial 29 000 MEF RCHEFC004 5 vial 1x10 cells vial Y15 000 ES ES RCHEFC003 5 vial 3x10 cells vial 29 000 C 3 2 ES RCHECK002 1 kit 56 000 ES 500 mM 30 m 25 m 4 Cosmo Bio News No 73 4C 0C 70C BERNER 196C ER Cellular Engineering Technologies EE NN NR SB Research Laboratories Cellular Engineering Technologies 1 Cord Blood Unrestricted Somatic Stem Cells HMPC 100 Cellula
60. Nanog ii ES EG STATG9 Nanog 9 EG 1 IN p ES 1 Vol 21 No 15 10 2003 SPA o 2 Mitsui K et al Cell 113 631 642 2003 se OHR Nano ael a
61. 1 mTOR TOR Fruman mTOR Complex 1 mTORC 1 Rag GTPase 3935 mTOR complex mTORC 323 Fruman 2 Taqll EER 85 39
62. Proteome Profiler ES ES StemTAG Nanog ES ES ES FBS Platinum StemTAG 96 INNO LiPA HPV Extra J D TrueORF cDNA NBL NE ATS osm C N E 1 OSMO Proteome Profiler 2 ES 2 ES StemTAG 3 Nanog 3 FRE EN HIV ES 4 q 3
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64. T MI HO C H HO C H RE d NERE del 2 3 L http www cosmobio co jp product raku 0025001 1 asp is Fn Vitamin C Assay kit ROIK02 1 kit Y 30 000 Cosmo Bio News No 73 13 om Multi Analyte Profiler ELISArray ELISA zi 12 x A SABiosciences TLR Multi Analyte Profiler ELISArrayIV ELISA 12 9 10 11 12 v e Z GM llLt2 ll FN fane GE v s k w 9 ek GM 7 ol ra P gt AHC L D 1 T IL10 fIL12 IL17A 1 IL10 fiL12 fIL17A TNF E R IL10 fiL12 fiza f I
65. a Wound Field DEDEH Wound Ea 1 CytoSelect 4 Well 09 50 100 STO STO MEF 24 DAFI l Q00 x OHER Cell Biolabs Inc CytoSelect 24 Well Wound Healing Assay CBA 120 1 meg FET 109 000 CBA 120 5 1 kit 5x24 assays 480 000 CometAssay CometAssay CometAssay CometAssay 4256 010 CC R DNA
66. Anti SSRP1 Drosophila Rabbit WB ELISA IHC IP ChIP NIG L1 SHA1 100 FF 50 000 Anti SPT16 Drosophila Rabbit WB ELISA IHC IP ChIP NIG L1 SHA2 100 ug 50 000 BAC Anti dCAMK II 18 Drosophila Mer WB IHC TNL 001 CAM 100 ug 40 000 Cosmo Bio News No 73 29 2008 Science AAAS American Association for the Advancement of Science Science Signaling Science Signaling x Science pn Signaling 2009 jor Breakthroughs of the year 2008 AAAS
67. pTUNE Inducible CDNA Search All Products EEE hor monii nsa 2 ani T ari region in pl bk racer g Fae JORF ones in Oriens t pihi baasid Fe dre sim Ths Bd pode Gr VEN na sr 0 a Par ke l pt p e fe ar Ho eieren ir ea OLE am via VERIFY Tagged Antigen Over expression Lysate TrueORF cDNA E R 8 10 000 HEK293T CC myc DDK DDK FLAG
68. CBA 300 ES 1 stemTAG CBA 301 ES ES D3 LIF a D3 LIF Cell Biolabs Inc CBL StemTAG Alkaline Phosphatase Staining Kit TET 1 i 52 000 StemTAG AP A StemTAG AP B StemTAG Alkaline Phosphatase Activity Assay Kit CBA 301 1 kit 55 000 StemTAG AP 10x QAP StemTAG Alkaline Phosphatase Complete Kit CBA 302 1 kit 76 000 amp CBA 300 CBA 301 Nanog RaprocErr 0CT3 4 POU5F 1 Nanog DAPI STAT3
69. HIiLyte FluorTM 64 7 CyD Cy5 HiLyte Fluor 647 GHiLyte Fluor 680 678nm 699nm Cy5 5 TAMRA R phycoerythrin HiLyte Fluor 647 3 4 GHiLyte Fluor 750 Cy 7 78nm OSE OPPEID 2 ED a Tublin HiLyteFluorrVw 594 IgG B 3T3 a Tublin HiLyteFluor 594 DAPI
70. MCM2 S27 MCM2 S108 Q A 7 All ustrious EA EA Z All ustrious mTFP Basic Alleleustrious mTFP I ECFP C FP mTFP 1 EGFP mTFP 1 YFP OFP FRET All ustrious mWasabi Basic Alleeystrious mWasabi GFP mWasabi EGFP GFP 5 E R EGFP 2 EDFP d3 EGFP
71. mRNA 200ug Santa Cruz Biotechnology Inc sShRNA V 116 000 200 Q OAA AA siRNA METH Lt siRNA DNA shRNA Dicer siRNA 4 4 siRNA PIN RISC mRNA EEE PN N N NN 4 mRNA Ee ISIN SNININ Cosmo Bio News No 73 9 MSTV S Pa Fa YYA NM FAK o ES MNT S Fa YYA NM FKA o ES PE Reagent NEW RNA SiRNA TnRNA miRNA siRNA mRNA mRNA RNAF
72. E G Methyl Profiler DNA Methylation Enzyme Kit Q ft PCR ARIENGS Corporation Fa ng 1 kit 12 samples Y 42 000 http Www cosmobio Co jp product raku 00580004 asp Methly Profiler PCR Cp DNA PCH miRNA 17 000 URL httop www sabiosciences com dna methylation custom php Methly ProfilerrM PCR Y27 000 200 rxn m MePH A 10 Cosmo Bio News No 73 UG 4C 60C 70C BERNER 196C
73. 500 m Y 28 000 Cosmo Bio News No 73 5 E S Pa GA YYA NM FAK o ES F F E S Fa YYA an NT FKA o ES ES ES GFP ES BGD1V ES BGO0O1V ES BGO 1V y C MEF 1 BGO1V CF 1 MEF GSC 6001M GFP ES GFP ES CMV 8 GFP LB10 ES Ready For Action ES S Heady For
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75. MHRP OTMBEE 20 G 2 E anm 48 k fa E m 1 PathProfiler ELISA Histone H3 Histone H3 S10 A549 HeLa K562 Jurkat 2 0 5 Ag 7M CalyCulin A 37C 5 COs 1 5 PathProfiler Total Histone H3 E300 001A Phospho Histone H3 910 E300 001B p fo Bethyl Laboratories Inc T sd Histone H3 ELISA Human Total Histone H3 E300 1 kit GER well 137 000 Histone H3 S10 MCM2 ELISA 2 E300 002 1 kit 96 well 137 000 A Total MCM2
76. DDK DDK FLAG A Switch OFF Mo Induction B Switch ON Induced IPTG d sila CMV HE CMV TetO 5 shRNA Target LacO LacQ 1 pTUNE 0 uM IPTG 2 5 uM IPTG 25 nM IPTG pTUNE pTUNE tGFP HEK2893 IPTG http www origene com GO kto T Wi Tech San OriGene Your Gene Company The trusted source for genome wide cDNA clones and shRNA ER bina p EP skog Baari li oP 2 Sir ee Wr fa 7 Register ER 2 AA Blast your or e Dy r AII Products v co
77. 5 T 1 592C0s 37 3 4 1 0 Mac 1 FITC 2X109 cells OA HE tt 50m2 OF HH tt 25m2 SD BMMO1 1 kit 94 000 P SD BMMC 1 vial 2x106cells 40 000 a TOPICS 5 s B IN COs 2 F R cli e COs CO0Oa 596
78. h 8 Multiple Analyte ELISArrayrV PMA 50ng 1 ul m2 PMBC Th1 Tho 0 6 18 24 48 IL IFN y TNF IL 4 IL 5 24 IL 10 IL 13 4 IL 1 Mimulti Analyte Profiler ELISArray eda Corporation SPA isse ei RD EE EE EE SR Th1 Th2 TH17 Cytokines Multi Analyte ELISArray Kit MEH TT 7 ap Y 84 000 IL 2 IL 4 IL 5 IL 6 IL 10 IL 12 IL 13 IL 17A IFN y TNF ao G CSF TGF B 1 H Th1 Th2 TH17 Cytokines Multi Analyte ELISArray Kit MS MEM 003A 1 array 84 000 IL 2 IL 4 IL 5 IL 6 IL 10 IL 12 IL 13 IL 17A IL 23 IFN y TNF a TGF B 1 Inflammatory Cytokines Multi Analyte ELISArray Kit HU MEH 004A 1 array 84 000 IL 1
79. mGluR2 Sealfon 2 Snyder 5HT mGluRH2 GPCH 8 19 GPCR GPCR Snyder 1 LTP
80. 3 DMSO 1 ES iPS 10 4 e aE 1 iPS ES RCHEMDOO1 5ng 7 bFGF ES amp MEF RCHEFCO003 A ES B 3min iPS 6G01B7 K Takahashi K Tanabe C 5 min M Ohnuki M Narita T lchisaka K Tomoda and S D
81. Er ELISA HIV Gag p24 p24 HIV 1 OPENER er ONARA OKI mm X101 _ EE EE ooaaa O p 4 B AE AR SE ORRE ME H7TVAFEDTUIKUNDTENVNIRUNZTE TI 1 EATA HIV 1 p24 HIV 1 p24 IgG 1 Age HIV 1 p24 ELISA Kit T 1 kit
82. RNA agRHNA HiboAmp HS Plus RNA 1ng total RNA 250 LCM R mRNA RNA MiraCol 1ng total RNA mRNA mes cDNA Gin 7 IVT Total Cellular RMA IVT CO IVT FEN iei eN ist Primer Synthesis IVT WMDNA RNA Tr EIJ aRNA FR by poet nd Strand Synthesis aRNA in mn mm M 1 53 Dsi bp 3 7 x fn Wiiro 500 Wee E s me r e 300 Amplified HIA cz WM TM TM WA TM NM B aTa TM TA 150 l mw MNA MNA 1 RNA RT PCH are total cellular RNA
83. BERNER 196C MEC Lymphetee P3U WM K562 y 1 Daudi B WM PC12 B OKT14 BB ee ST 12 800 Platinum iPS Platinum Platinum gag
84. pol Platinum _ X10 1x10 infectious units m2 3 ES EC E 1 Platinum Plat E Cells Plat GP Cells Plat A Cells GA AA CELL BIOLABS INC Ecotropic Pantropic rr N S Mouse Platinum Rat rn z PEI VSV G Monkey BE N S nai Cat N S Dog N S Hamster N S db
85. 68 000 NNP 1 SCB SC 83323 100 ug Y51 000 Collagen c 1 type 23 RSD MAB4165 100 ug 42 000 NSE P1 CL CL2721AP 200 ug 48 000 Complement Proteins GIT AHC3 0 5 mg 33 000 Nuclear Envelope Membrane Protein LSP LS B1979 50 50 ug Y 62 000 CRYZL1 SCB SC 83233 100 ug 51 000 Nucleoporin NSP1 LSP LS C51023 100 100 ug 84 000 CSPP1 PGI 11931 1 AP 150 u 68 000 0 Cullin 4A B EPT 2527 1 1004 60 000 OCA B EPT 100 u Y60 000 Cytonectin GIT AHC 10 mg 70 000 osteopontin c GIT AHOPNC 0 1 mg 117 000 CYYR1 SCB SC 83236 100 ug Y51 000 P B Peptidylprolyl Isomerase A Like 3 LSP LS C26117 500 500 ug 113 000 DECR 1 SCB SC 130369 100 ug 58 000 PFN4 PGI 12796 1 AP 150 u2 68 000 Dimethyl Lysine BMO SA667 0100 100 u 55 000 p Go 12 SCB SC 130191 100 ug 51 000 DISPA PGI 12041 1 AP 150 u 68 000 PHYH PGI 12858 1 AP 150 u2 68 000 DNA polymerase 5 subunit p66 BAM 70 055 50 ug Y25 000 PI4Kinasell oc SCB SC 130231 100 ug Y51 000 DNA replication protein LSP LS C50777 50 50 ug Y190 000 PIPKII y SCB SC 130234 100 ug 51 000 DNAK LSP LS C50788 1 1ml 95 000 Piwi Like 1 LSP LS C51669 40 40 ug 64 000 E PLGLB 2 SCB SC 130390 50 ug 58 000 E coli Tet Repressor LSP LS C40754 100 100 ug 64 000 PMP 2 PGI 12717 1 AP 150 pk 68 000 EDIL3 PGI 12580 1 AP 150 u 68 000 POFUT1 PSC 4765 0 1 mg 59 000 EH domain binding protein 1 ADI 7383 100 ug 78 000 PRAK SCB SC 130212 100 ug 51 000 ELAC 1 CBX
86. ECFP 2 r 3 2 ns W HFP YFP pH pKa 4 3 GReady to transfect O BFP RFP pH pKa 4 3 GReady to transfect O Allele sl and a Inc Allele ustrious pNCS mTFP1 ABP Yi 0 10 pe 98 000 ar Allele ustrious pmTFP1 N ABP FP TNNCS10 10 ug 98 000 27 AII ustrious pmTFP1 C ABP FP TCNCS10 10 ug 98 000 Allele ustrious DNCS mWasabi ABP FP WPNCS10 10 ug Y 98 000 AIIe ustrious pmWasabi N ABP FP WNNCS10 10 ug Y 98 000 c Allele ustrious pmWasabi C ABP FP WCNCS10 10 ug Y 98 000 P Q MTA Material Transfer Agreement
87. NEW CytoSelect 24 Well Idin vitro amp wound 0 9mm a TOR IE wound ee R OZAR ADS 024 Well CytoSelect 24 Well es Mound Hasing dell meme tt KOTE ANG EE Hna Tas EMGS ME 24 48 Fl Ea Wur Fei MA HAt AKG SET 0 8 mm D Wound Field R EG Wound Field es ar ar
88. Randall Moon RNA RNA shRNA siRNA G 1 1 Harlow 69 Uk Moon shRNA siRNA
89. 008 2008 Signaling Breakthroughs of the Year Si gnali ng Elizabeth M Adler Associate Editor of Science Signaling American Association for the Advancement of Science 1200 New York Avenue N W Washington DC 20005 USA B o 20084 Science Signaling 1
90. 488nm 590nm fo A E PAET E L 15 0 E TE SA uiket MItoPT Y TRBL KVA DRU EUT RL A a LA AE A EER MEET R E a a e a TN SENT OSHIR li lint Technologies LLC MitoPT Mitochondrial Membrane Permeability JC 1 924 n Y 27 000 Transition Detection Kit 911 400 test 53 000 _ MitoPT 10x MitoPT W TMRE TMRM KR MitoPT TMRE Mi
91. Bird N S N S Fish N S N S Frog N S N S Insect N S N S Mollusk N S N S Cell Biolabs Inc CBL a Me Platinum ES EC Retroviral Expression System Ecotropic Plat E Ecotropic pMCs Puro pMCs GFP VPK 303 157 000 A Platinum ES EC Retroviral Expression System Amphotropic Plat A Amphotropic pMCs Puro pMCs GFP VPK 304 ar 157 000 Platinum ES EC Retroviral Expression System Pantropic Plat GP Pantropic pMCs Puro pCMV VSV G pMCs GFP VPK 305 1 kit 157 000 Platinum HSC Retroviral Expression System Ecotropic Plat E Ecotropic pMYs Puro pMYs GFP VPK 306 1 kit 157 000 E Platinum HSC Retroviral Expression System Amphotropic Plat A Amphotropic pMYs Puro pMYs GFP VPK 307 1 kit 157 000 E Platinum HSC Retroviral Expression System Pantropic Plat GP Pantropic pMYs Puro pCMV VSV G pMYs GFP VPK 308 1 kit 157 000 Q Cosmo Bio News No
92. Mili et al Genome wide screen reveals APC associated RNAs enriched in cell protrusions Nature 453 1 15 119 2008 3 W Tang et al A genome wide RNAi screen for Wnt catenin pathway components identifies unexpected roles for TCF transcription factors in cancer Proc Natl Acad Sci U S A 105 9697 9702 2008 4 M B Major et al New regulators of Wnt catenin signaling revealed by integrative molecular screening Sci Signal 1 ra 12 2008 5 A Baldwin et al Kinase requirements in human cells Il Genetic interaction screens identify kinase requirements following HPV 16 E7 expression in cancer cells Proc Natl Acad Sci U S A 105 16478 16483 2008 6 A Bommi Reddy et al Kinase requirements in human cells Ill Altered kinase requirements in VHL cancer cells detected in a pilot synthetic lethal screen Proc Natl Acad Sci U S A 105 16484 16489 2008 7 D A Grueneberg et al Kinase requirements in human cells I Comparing kinase requirements across various cell types Proc Natl Acad Sci U S A 105 16472 16477 2008 8 D A Grueneberg et al Kinase requirements in human cells IV Differential kinase requirements in cervical and renal human tumor cell lines Proc Natl Acad Sci U S A 105 16490 16495 2008 9 M Isalan et al Evolvability and hierarchy in rewired bacterial gene networks Nature 452 840 845 2008 10 M R Bennett et al Genome rewired Nature 452 824 825 2008
93. Sci STKE 2007 pe8 2007 J G Pan et al Metabolic targeting as an anticancer strategy Dawn of a new era Sci STKE 2007 pe 14 2007 Reviews A M Preininger et al G protein signaling Insights from new structures Sci STKE 2004 re3 2004 A Contractor et al Glutamate receptor trafficking in synaptic plasticity Sci STKE 2002 re 14 2002 T E Harris et al TOR signaling Sci STKE 2003 re15 2003 S Marshall Role of insulin adipocyte hormones and nutrient sensing pathways in regulating fuel metabolism and energy homeostasis A nutritional perspective of diabetes obesity and cancer Sci STKE 2006 re7 2006 Research E Ciraolo et al Phosphoinositide 3 kinase p1 10_ activity Key role in metabolism and mammary gland cancer but not development Sci Signal 1 ra3 2008 Virtual Journal C D Harvey et al The spread of Ras activity triggered by activation of a single dendritic spine Science 321 136 140 2008 M Heine et al Surface mobility of postsynaptic AMPARs tunes synaptic transmission Science 320 201 205 2008 R A Silver et al Refreshing connections Science 320 183 184 2008 Y Sancak et al The Rag GTPases bind raptor and mediate amino acid signaling to mTORC 1 Science 320 1496 1501 2008 References 1 J Zhu et al Integrating large scale functional genomic data to dissect the complexity of yeast regulatory networks Nat Genet 40 854 861 2008 2 S
94. controls hydrophobic motif phosphorylation and activation of serum and glucocorticoid induced protein kinase 1 SGK1 Biochem J 416 375 385 2008 33 V Facchinetti et al The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C EMBO J 27 1932 1943 2008 34 T Ikenoue et al Essential function of TORC2 in PKC and Akt turn motif phosphorylation maturation and signalling EMBO J 27 1919 1931 2008 35 W Cao et al Toll like receptor mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin sensitive PI 3 K mTOR p70S6K pathway Nat Immunol 9 1157 1164 2008 36 T Weichhart et al The TSC mTOR signaling pathway regulates the innate inflammatory response Immunity 29 565 577 2008 37 L V Sinclair et al Phosphatidylinositol 3 0H kinase and nutrient sensing mTOR pathways control T lymphocyte trafficking Nat Immunol 9 513 521 2008 38 V A Narkar et al AMPK and PPAR agonists are exercise mimetics Cell 134 405 415 2008 39 V Gomez Roldan et al Strigolactone inhibition of shoot branching Nature 455 189 194 2008 40 M Umehara et al Inhibition of shoot branching by new terpenoid plant hormones Nature 455 195 200 2008 41 H Klee Hormones branch out Nature 455 176 177 2008 From E M Adler 2008 Signaling Breakthroughs of the Year Sci Signal 2 eg 1 2009 2009 AAAS All rights reserved 32 Cosmo B
95. siRNA 47 000 10 M x50 100 shRNA R shRNA 19 5nt 3 5 ale shRNA siRNA Transfection Ready DNA RT PCRH 99 56 shRNA shRNA Plasmid Transfection Reagent SC 10806 1 shRNA Plasmid Transfection Medium SC 108062 Santa Cruz Biotechnology Inc shRNA SH 97 000 20ug Q
96. 22 Cosmo Bio News No 73 DSHI JAV http Www origene com Lysate GO mr 4C 60C 70C BERNER 196C cs t PathProfiler ELISA o rn NR S E BETHYL sm i _ PathProfilerrM ELISA 96 2
97. 73 C 2 ES S Pa FANN SNS NT FKA o DE E S Pa ANINE an NM FAK o ES StemTAG 96 7 lt 10 ES StemTAGTM 86 10 ES 3 1 2 3 7 10 OZAR OA ceumoues me CytoSelect 10X MCytoSelectrM
98. 96 assay Ye0 000 50 000 Q 2009 3 31 HIV 1 p24 ELISA 16 Cosmo Bio News No 73 mr 4C 60C 70C BERNER 196C amp Sy emph p TOPICS Monocyte ARAN CRT SKA Common Precursor Cell BEND EROBRET M CSF Macrophage Colony Stimulating Factor Anti Mac1 FITC
99. Action M ES ES Heady For ActionW ES ES ES GlobalStem Inc TE GlobalStem BGO1V Human Embryonic Stem Cell Line BG01 ES GSC re 1 Vie 116 000 CF 1 MEF Mitomycin C treated E 3 GSC 6001M 4 5x105 cells vial 11 000 E LB10 Mouse Embryonic Stem Cells C57BI 6 9 GSC 5003 3x106 cells vial 116 000 Pa LC3 Mouse Embryonic Stem Cells F1 hybrid C57BI 6x129 9 GSC 5002 3x106 cells vial 116 000 Ready For Action ES DMEM F12 Optimized for human ESC culture GSM 1002 500 m Y 7 000 Ready For Action ES DMEM Optimized for mouse ESC culture GSM 2001 500 m Y 6 000 ES Qualified Fetal Bovine Serum FBS GSM 6001 500 m Y 68 000 ar GSM 6002 100 mg 18 000 ES FBS AK ES
100. CBX00720 100 ug Y39 000 R Elongation Protein 2 LSP LS C46983 100 100 ug 73 000 RNA polymerase 3 LSP 50 ul Y74 000 Endothelial Basement Membrane ADI 7339 100 ug Y 78 000 T ENPP6 PGI 12643 1 AP 150 ul Y68 000 TRAMI PGI 150 ug Y68 000 Enterotoxin B precursor LSP LS C50947 1000 1000 ug 115 000 U Erythroid a Spectrin MNS MNS MON8030 100 ug 85 000 UBE2F SCB SC 130284 100 ug Y51 000 Erythroid B Spectrin MNS MNS MON8031 100 ug 85 000 UBL4A SCB SC 130285 100 ug 51 000 Esherichia coli heat labile enterotoxin A chain AIC 1 ECEA 200 ug Y73 000 UCH L1 3 LFR LF PA0197 100 u2 63 000 Esherichia coli heat labile enterotoxin B chain AIC 1 ECEB 200 ug 73 000 UDP galactose LSP LS C51647 40 40 ug Y 64 000 EXOSC1 PGI 12585 1 AP 150 u Y68 000 URG 4 PGI 11998 1 AP 150 u2 68 000 F F Ab 2 Frag ICN 617911 1ml 79 500 VASH1 12730 1 AP 150 u2 68 000 Factor 8 A EPT 2559 1 100 u 60 000 VEGF E 102 PA70 50 ug 27 000 FLJ 20433 SCB SC 130139 100 ug Y51 000 Viperin 210 956 C100 100 ug 63 800 FN3KRP SCB SC 130140 100 ug Y51 000 Follistatin Like4 RSD AF4890 100 ug 74 000 YIPF5 PGI 150 ug 68 000 FSAP ADI 4601 250 ug 115 000 YP2 CL CLAS05 057 200 u 106 000 FVlla CL CLAS00 001 250 ug Y104 000 Z G ZMYM3 SCB SC 130039 100 ug Y51 000 G Protein Coupled Receptor LGR7 LSP LS C47303 100 100 ug 64 000 ZSCAN18 SCB SC 130043 100 ug Y51 000 28 Cosmo Bio News No 73
101. amp SA DNA PCR Re OF NER EET yN INNO LiPA HPV Extra 27 er P18 TrueORF cDNA 37 000 cDNA P18 24 gt HITS 7 P25 gt
102. year Sci STKE 2004 eg 1 2004 M Adler N R Gough L B Ray 2002 Signaling breakthroughs of the year Sci STKE 2003 eg 1 2003 A M VanHook Facilitating multicellularity Sci Signal 1 ec262 2008 L B Ray Don t try this at home Sci Signal 1 ec137 2008 J F Foley Just when you thought it was pseudo Sci Signal 1 ec138 2008 S M Hurtley Spreading the word Sci Signal 1 ec248 2008 P Stern Fast receptors in every respect Sci Signal 1 ec136 2008 N R Gough Pyruvate kinase for cancerous metabolism Sci Signal 1 ec97 2008 L B Ray Location matters Sci Signal 1 ec225 2008 N R Gough The benefits of exercise without the sweat Sci Signal 1 ec284 2008 E M Adler New ramifications of strigolactone signaling Sci Signal 1 ec322 2008 Perspectives K Morita Computational implications of cooperative plasticity induction at nearby dendritic sites Sci Signal 2 pe2 2009 L Cognet et al Multiple routes for glutamate receptor trafficking Surface diffusion and membrane traffic cooperate to bring receptors to synapses Sci STKE 2006 pe 13 2006 W G Kaelin Jr Gleevec Prototype or outlier Sci STKE 2004 pe 12 2004 J J Zhao et al PI3 kinases in cancer From oncogene artifact to leading cancer target Sci STKE 2006 pe52 2006 L Bozulic et al Meeting report Targeting the kinome 20 years of tyrosine kinase inhibitor research in Basel
103. 000 Neural Differentiation Media NEUDMEDIA450 450 m 54 000 Amniotic Epithelial Stem Cell Expansion Media HAECEMEDIA450 450 m 27 000 Cord Blood Multipotent Unrestricted Somatic Stem Cell Expansion Media HMPCEMEDIA450 450 mk 14 000 Hematopoietic Stem Cell Expansion Media HSCEMEDIA80 80 ml 183 000 Mesenchymal Stem Cell Expansion Media HMSCEMEDIA450 450 m 14 000 ScienCell Research Laboratories EN T T ET ScienCell Research Laboratories ScienCell Research Laboratories ne VE Mesenchymal Stem Cells bone marrow Human 7500 5x1 3 Gelle vial 177 000 sr Mesenchymal Stem Cells adipose Human 7510 5x10 cells vial 177 000 Mesenchymal Stem Cells hepatic Human 7520 5x10 cells vial 177 000 Umbilical Mesenchymal Stem Cells Human 7530 5x105 cells vial 177 000 Mesenchymal Stem Cells bone marrow Mouse M7500 5x10 cells vial 93 000 Mesenchymal Stem Cells bone marrow Rat R7500 5x10 cells vial 93 000 Pa Mesenchymal Stem Cells adipose Canine D7510 5x10 cells vial 102 000 E Mesenchymal Stem Cells adipose Equine H7510 5x10 cells vial 117 000 Mesenchymal Stem Cell Medium 7501 ScienCell Research Laboratories SCR
104. 00000000000000000000 D5 RE iPS ES Ready to use ES 3 4bFOF iPS ES am ESP IN ER bFGF 0 pH smsarett he niis 1 E ES ReproFF 000000000000000000000000000000000000000000000000000000000000000060 T ER F ES 30 O OE RES MA HH RCHEMDOO1 002 EG
105. 11 G Manning et al The protist Monosiga brevicollis has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan Proc Natl Acad Sci U S A 105 9674 9679 2008 12 D Pincus et al Evolution of the phospho tyrosine signaling machinery in premetazoan lineages Proc Nati Acad Sci U S A 105 9680 9684 2008 13 B J Mayer Clues to the evolution of complex signaling machinery Proc Natl Acad Sci U S A 105 9453 9454 2008 14 K Mukherjee et al CASK functions as a Mg independent neurexin kinase Cell 133 328 339 2008 15 N Kannan et al Rethinking pseudokinases Cell 133 204 205 2008 16 J Gonz lez Maeso et al Identification of a serotonin glutamate receptor complex implicated in psychosis Nature 452 93 99 2008 17 S H Snyder A complex in psychosis Nature 452 38 39 2008 18 J H Park et al Crystal structure of the ligand free G protein coupled receptor opsin Nature 454 183 187 2008 19 P Scheerer et al Crystal structure of opsin in its G protein interacting conformation Nature 455 497 502 2008 20 C D Harvey et al The spread of Ras activity triggered by activation of a single dendritic spine Science 321 136 140 2008 21 M Heine et al Surface mobility of postsynaptic AMPARs tunes synaptic transmission Science 320 201 205 2008 22 R A Silver Surface Refreshing connections Science 320 183 184 2008 23 M Eiraku et al S
106. 1G CF 61 CF 110 20 1 1 20 1 6 000 5 700 Y12 000 Y7 000 7 000 Cosmo Bio News No 73 7 MHNT gt Va SI NT FKA o 1 TOPICS E R OSTE 18 7 HPV HPV HPV Ready tO use 7gg9 9 1 48 3 LiPA HPV LiRAS En IN INNO LiPA HPV Genotyping Extra INNO LIPA HPVEISFERE F h Extra m 27 em Single types 16
107. 55 654 9996 siRNA 1 20 25nt siRNA 3nmol siRNA 50 100 mRNA RT PCRH PR siRNA siRNA p53 siRNA h SC 29435 HeLa A HeLa B siRNA p53 HeLa p53 SC 6243 Santa Cruz Biotechnology Inc SCB
108. 77 000 BCNP1 SCB SC 130092 100 ug 51 000 Major Urinary Protein NOR GAM MUP 1ml 34 000 BRWD1 LSP LS C18545 500 500 ug Y113 000 Malignant Melanoma Metastasis Suppressor LSP LS C48546 100 100 ug 84 000 BU A1 LSP LS C44358 100 100 test Y101 000 Membrane Associated Protein 17 ADI 7317 100 ug 78 000 C Mesothelial Cell CMC CXA128 7ml 49 000 C13 orf3 SCB SC 84026 100 ug Y51 000 Mex3b SCB SC 130169 100 ug Y51 000 C21 orf128 SCB SC 83220 100 ug 51 000 MOBKL1A SCB SC 130175 100 ug Y51 000 C21 orf55 LSP LS C12191 500 500 ug Y113 000 MYCBPAP PGI 12763 1 AP 150 u2 68 000 CAPZA3 SCB SC 130480 50 ug 58 000 Myleloperoxidase GIT AHM 0 1 mg 42 000 Carbonic Anhydrase 5A 5B RSD MAB5388 100 ug 42 000 Myosin lc SCB SC 130177 100 ug Y51 000 Carbonyl Reductase 3 SCB SC 70218 200 ug Y51 000 N CCDC44 LSP LS B1161 50 50 ug Y62 000 NAD dependent Methylenetetrahydrofolate Dehydrogenase LSP LS C32329 50 50 ul 74 000 CCL9 LSP LS C48884 100 100 ug 92 000 NADH Dehydrogenase 1c Subcomplex 12 LSP LS C32564 50 50 ul Y 87 000 CD205 RCC CL CL2834AP 7 7m 67 000 NAGLU SCB SC 130383 100 ug 58 000 CLASP2 PGI 12942 1 AP 150 u 68 000 NALP 13 SCB SC 68680 200 ug 51 000 CLC KB SCB SC 130093 100 ug 51 000 Neuron specific B 3 Tubulin NL 557 RSD NL1195R 0 5m 72 000 CLSTN1 PGI 12788 1 AP 150 ul 68 000 Neuron specific B 3 Tubulin NL 637 RSD NL1195V 0 5 ml 72 000 CMIP PGI 12851 1 AP 150 ul
109. 9 3 Ras reproduced from 20 T David Fruman Facundo Batista B 422 BB BCR BCR CD 1 9 CD 1 2 CD19 CD2 1 CD198
110. 96 K 1kit 96 test 263 000 PE C wa Sa pj rn C L KALRN AZ ODORAS SH FT C AsA id cAI w je DHAsA ORAI SWAP AsA DHAsA O GSE 3 DNPH en 44 TARE sr 50 Pla 1973 Daniel W B A 5 a 10m C L 1ml 1 Si Gladys E James E M Clinica Chimica Acta 44 47 52 1973 l l 00 50 9 a CHOH COOH ReOAN J COOH C L oH 0 C RANN C or 0 0 MK gt RHNN C o ZA
111. A IL 1B IL 2 IL 4 IL 6 IL 8 IL 10 IL 12 IL 17A IFN y TNF o GM CSF Inflammatory Cytokines Multi Analyte ELISArray Kit MS MEM 004A 1array 84 000 IL 1A IL 1B IL 2 IL 4 IL 6 IL 10 IL 12 IL 17A IFN y TNF c G CSF GM CSF Autoimmune Response Multi Analyte ELISArray Kit HU MEH 005A 1 array 84 000 IL 1B IL 4 IL 6 IL 10 IL 12 IL 17A IFN y TNF c TGF B 1 MCP 1 MIP 1a MIP 1b Autoimmune Response Multi Analyte ELISArray Kit MS MEM 005A 1 array Y 84 000 IL 1B IL 4 IL 6 IL 10 IL 12 IL 17A IFN y TNFa TGF B 1 MCP 1 MIP 1a MIP 1b Common Cytokines Multi Analyte ELISArray Kit HU MEH 006A 1 array 84 000 EA IL 1A IL 1B IL 2 IL 4 IL 5 IL 6 IL 8 IL 10 IL 12 IL 13 IL 17A GM CSF Common Cytokines Multi Analyte ELISArray Kit MS MEM 006A 1 array 84 000 IL 1A IL 1B IL 2 IL 4 IL 5 IL 6 IL 10 IL 12 IL 13 IL 17A G CSF GM CSF TLR induced Cytokines Multi Analyte ELISArray Kit HU MEH 007 A 1 array Y 84 000 TNF amp IL 1 B IL 6 IL 12 IL 17A IL 8 MCP 1 RANTES IP 10 MIG TARC IFN TLR induced Cytokines II Multi Analyte ELISArray Kit HU MEH 008A 1 array Y 84 000 TNF amp IL 1 B IL 6 IL 12 IL 17A IL 8 MCP 1 RANTES MIP 1 c MIP 1P MDG Eotaxin Common Chemokines Multi Analyte ELISArray Kit HU MEH 009A 1 array 84 000 IL 8 MCP 1 RANTES MIP 1 MIP 1 B IP 10 I TAG MIG Eotaxin TARC MDC GRO a
112. Cancer Complete Panel 96 genes Methyl Profiler PCR amp DNA A sabiosciences 1 DNA Input DNA 37C 6 hr overnight I RI SYBR Green qPCR Master Mix 2 PCR Mock DNA Sensitive Werema Dependent on MD TTS E RIE DNA Double 3 3 Total Input DNA ok BE a2 JOKI NVERE SABioscience Corporation SPA 2 96 well 95 000 MeAH 011X 1 12 12 96 well Y 294 000 MeAH 011X 1 24 24 96 well Y 462 000 MeAH 011X 2 4 4 384 well 210 000 MeAH 8010X 1 4 x 2 4x96 well 210 000 MeAH 3010X 2 2 2 384 well 168 000 MeAH 3010X 2 12 12 384 well 525 000 MeAH 3010X 2 24 24 384 well 840 000 Q X PCR http Www cosmobio COo jp product raku 002580004 asp 1 A C D F
113. EE TN mi eV RE ES ES SC 008 ES EPC Oct 3 4 Goat Q SSEA 1 clone MC 480 isotype mouse IgM O O SSEA 4 clone MC 813 70 isotype mouse IgG3 O O CD 9 clone 209306 isotype mouse IgG2B O E Cadherin clone 180224 isotype mouse IgG2B O PODXL clone 222328 isotype mouse IgG2B O SOX2 clone 245610 isotype mouse IgG2A O R amp D ui Inc RSD Embryonic Stem Cell Marker Antibody Panel SC008 1 kit Yoe 000 Embryonic Stem Cell Marker Antibody Panel Plus SC009 1 kit 128 000 2 Cosmo Bio News No 73 4C 0C 70C BERNER 196C ES StemTAGW ES AA eert moraes NG GE StemTAG
114. FACT DNA GAGA SSRP1 dSSRP 1 SPT16 dSPT16 FACT GAGA CAC ChIP 1 Shimojima T et al 2003 Genes amp Dev 17 1605 1616 2 Saunders A et al 2003 Science 301 1094 1096 3 Nakayama T et al 2007 Genes amp Dev 21 552 56 I 1 GAGA FACT me BR ATKAORERE DNA dSSHP 1 dSPT1 6 MERE
115. FN NE GSE GM 1 c E ol fra GM me E N E E EE ELISArraytm 12 8 i ELISA ag 0 IL2 IFN y TNF a 9 1L13 IL10 9 1L4 IL5 9 1L12 IN fo L T Bd6 8 128 Ing ul 124 12 g gt Avidin HR PIE 8 1 0 BSA Oen MA 1 0Q Z J 6 12 18 24 30 36 42 48 T
116. GO D L EP dd Par 1 pBT3 SUC NMY51 2x96 test en N g 5 p 77 z s EA ee AM II pBT3 N 1 pm PPE rm Fr LE DETS SE Yy CN N FIF o H ban 2 AU LOR MERE He pBT9 SUC 2 CDNA DUALmembrane SA pBT3 STE N interaction PO01501 cDNA PO01010 E Dualsystems Biotech AG DSB VE V RE T T 3 a ER DUALmembrane starter kit Mouse adult brain cDNA library NubG x Pot 401 E 301 PO1 201 1 kit 477 000 Jurkat T cDNA library NubG x P01402 P01302 P01202 1 kit 477 000 J Mouse adult heart cDNA library x NubG P01403 P01303 P01203 1 kit 477 000 Mouse adult heart cDNA library NubG x P01404 P01304 P01204 1 kit 477 000 Human adult kidney cDNA library x NubG P01405 P01305 P01205 1 kit 477 000 Human adu
117. I Solomon Snyder 1 6 04 15 Snyder 10 1 Thomas Sudhof Markus Wahl 1 CASK 6 3 AMP 1 CASK CaM CASK rep
118. PIP1 2 COP COP 080028 100 u2 30 000 HePTP SCB SC 130193 100 ug 51 000 Aquaporin PIP1 1 PIP1 2 COP COP 080029 100 u 30 000 Histone H2B Type 2F LSP LS C49727 100 100 ud 91 000 Aquaporin PIP1 1 PIP1 2 PIP1 3 COP COP 080025 100 u 30 000 hnRNP UL1 SCB SC 101976 100 ug Y51 000 Aquaporin PIP2 1 PIP2 2 PIP2 3 COP COP 080027 100 ug Y 30 000 Human Papilloma virus type 18 E6 LSP LS C49063 100 100 ug 77 000 Aquaporin PIP2 2 COP COP 080026 100 u 30 000 Hypoxia Inducible Factor Prolyl 4 hydroxylase LSP LS C49068 100 100 u Y77 000 ARMC3 PGI 12856 1 AP 150 ul Y68 000 ARMC8 PGI 12653 1 AP 150 u 68 000 IFITM 2 PGI 12769 1 AP 150 u2 68 000 ARNO3 LSP LS C49613 100 100 u2 91 000 Insulin Induced Protein 1 LSP LS C49148 100 100 pk 77 000 AROS ALX 210 961 C100 100 ug 63 800 IPPK PGI 12603 1 AP 150 u2 68 000 ARPC5 LSP LS C49916 100 100 ud 91 000 Islet Cell Autoantigen 1 LSP LS C32190 50 50 ug 87 000 ATP6V1A1 LSP LS B640 50 50 ug Y62 000 K ATPase 13A2 LSP LS C49134 100 10042 77 000 KCNJ1 LSP 100 u Y91 000 AtPDR8 COP COP 080007 100 u 30 000 KIFAP3 PGI 12700 1 AP 150 u2 68 000 a c Myc JNA ABD 034 50 ug 79 000 M a protein kinase 1 SCB SC 130111 100 ug 51 000 Major Occlusion Body Protein LSP LS C32584 50 50 ul 87 000 B Major Outer Membrane Porin LSP LS C50781 1000 1000 ug Y125 000 BAGE SCB SC 19086 200 ug 51 000 Major Structural Protein Of Myelin LSP LS C47499 50 50 ug
119. RTIID IE pk me TM 3 ELET PAHP SPARRIDOTIURERK PARP PeroxyGlow A TM AAR PAR SPARP PeroxyGlow B pe i PARP in vo 920 W V SDS f PAR 9 O0X OMEI 71 7M ON GE Jurkat OT FIG ADP am PAR PAH PARP fo PARP p de i er rd am ei i i Pu 96 10pg m2 ENSFvtTET ATSIET hwo TD r 1 PAHP Trevigen Inc PARP in vivo Pharmacodynamic Assay 4510 0
120. bG x P01424 P01324 P01224 1 kit 477 000 SA Mouse whole embryo 11 days cDNA library NubG x P01425 P01325 P01225 1 kit 477 000 E Medicago nodules cDNA library x NubG P01426 P01326 P01226 1 kit 477 000 Medicago nodules cDNA library NubG x P01427 P01327 P01227 1 kit 477 000 Saccharomyces cerevisiae cDNA library NubG x P01428 P01328 P01228 1 kit 477 000 Normalized mouse embryo cDNA library x NubG P01429 P01329 P01229 1 kit 477 000 1 cDNA DUALmembrane pairwise interaction PU01501 cDNA PU1010 Dualsystems Biotech AG DSB DUALmembrane pairwise interaction kit P01501 1 kit 477 000 E pBT3 N pBT3 SUC pBT3 STE pPR3 N pPR3 SUC pPR3 STE pOst1 Nubl pTSU2 APP pNubG Fe65 NMYS1 Cosmo Bio News No 73 21 MNT S Fa YYA NM FAK o ES NEW EKNMUFIDYA TrueORF cDNA 70 2 37 000 cDNA A ORIGENE TECHNOLOGIES INC TrueORF cDNA 37 000 CDNA
121. be NPI HP1 100 1 Hypoxyprobem 1 Liu L F and Wang J C 1987 Proc Natl Acad Sci USA 84 7024 7027 2 Matsumoto K and Hirose S Visualization of unconstrained negative supercoils of DNA on polytene chromosomes of Drosophila 3 Wadia J S and Dowdy S F 2002 Curr Opin Biotech 12 52 56 BEEN NIG L1 R1 3x4 40 000 ccocoooooooooo0000000000000000000000000000000000000000000000000000009 DNA FACT Facilitates Chromatin Transcription SSRP 1 SPT16
122. elf organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals Cell Stem Cell 3 519 532 2008 24 E Arana et al Activation of the small GTPase Race via the B cell receptor regulates B cell adhesion and immunological synapse formation Immunity 28 88 99 2008 25 D Depoil et al CD19 is essential for B cell activation by promoting B cell receptor antigen microcluster formation in response to membrane bound ligand Nat Immunol 9 63 72 2008 26 K B Lin et al The rap GTPases regulate B cell morphology immune synapse formation and signaling by particulate B cell receptor ligands Immunity 28 75 87 2008 27 M Weber et al Phospholipase C gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane bound antigen J Exp Med 205 853 868 2008 28 B Apsel et al Targeted polypharmacology discovery of dual inhibitors of tyrosine and phosphoinositide kinases Nat Chem Biol 4 691 699 2008 29 H R Christofk et al The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth Nature 452 230 233 2008 30 E Kim et al Regulation of TORC 1 by Rag GTPases in nutrient response Nat Cell Biol 10 935 945 2008 31 Y Sancak et al The Rag GTPases bind raptor and mediate amino acid signaling to mTORC 1 Science 320 1496 1501 2008 32 J M Garcia Martinez et al mTOR complex 2 MTORC2
123. io News No 73 J http www cosmobio co jp product campain asp Qi MyRun 5 60960FF 009 16 5 15 i MyRun 7 209 0FF i MyRun Piko 009g 1 5 3 31 PikorW PCH 1 e Myco amp e Myco plus 25 0FF 009 9 3 31 e MycorM PCOH e Myco Plus 5960FF e MycorM Plus e MycorV gDNA
124. lt liver cDNA library x NubG P01406 P01306 P01206 1 kit 477 000 Arabidopsis cDNA library NubG x P01407 P01307 P01207 1 kit 477 000 HeLa cell line cDNA library NubG x P01408 P01308 P01208 1 kit 477 000 Human embryonal brain cDNA library NubG x P01409 P01309 P01209 1 kit 477 000 Human adult colon cDNA library NubG x P01410 P01310 P01210 1 kit 477 000 C elegans whole adult cDNA library NubG x P01411 P01311 P01211 1 kit 477 000 Human adult liver cDNA library NubG x P01412 P01312 P01212 1 kit 477 000 Human adult brain cDNA library NubG x P01413 P01313 P01213 1 kit 477 000 C elegans whole eggs DNA library NubG x P01414 P01314 P01214 1 kit 477 000 D melanogaster embryo cDNA library NubG x P01415 P01315 P01215 1 kit 477 000 Mouse adult spleen cDNA library x NubG P01416 P01316 P01216 1 kit 477 000 Human adult kidney cDNA library NubG x P01417 P01317 P01217 1 kit 477 000 Human adult brain cDNA library x NubG P01418 P01318 P01218 1 kit 477 000 LNCaP cells cDNA library NubG x P01419 P01319 P01219 1 kit 477 000 Drosophila melanogaster cDNA library NubG x P01420 P01320 P01220 1 kit 477 000 Human adult lung cDNA library NubG x P01421 P01321 P01221 1 kit 477 000 amp Mouse adult kidney cDNA library NubG x P01422 P01322 P01222 1 kit 477 000 Mammary epithelial cells cDNA library NubG x P01423 P01323 P01223 1 kit 477 000 Rat neonatal cardiomyocyte cDNA library Nu
125. put DNA 1 10 PCR 6 amp PCR Methyl Profiler M PCH 4 96 DNA FU GMethyl Profilerrm PCR v t 1 DNA PCRH Breast Cancer Biomarker Validation Hypermethylated DNA Blood MCF7 SKBR3 MDA MB 231 Cell Lines 1 MethyIProfilerw PCR MCF7 SKBR3 MDA MB 23 1 Human Breast Cancer Signature Panel Methyl Profilerr PCR DNA 3 DNA 224 Methly Profiler PCR Methyl Profiler DNA Methylation PCR Array Human Breast Cancer Signature Panel MeAH 011X 1 2 24 genes Methyl Profiler DNA Methylation PCR Array Human Breast
126. r OHA 20 HIL Til PBS pH7 4 Anti Nanog Rabbit HU MS MKY WB IC IP RCAB0001P 200 ug 0 2 mg m 54 000 Rabbit HU MS MKY WB IC IP RCAB0002P F 100 ug 0 2 mg m 28 500 Rabbit HU WB IC RCAB0003P 200 u2 0 2 mg m 54 000 Rabbit HU WB IC RCAB0004P F 100 ug 0 2 mg m 28 500 Q F 0 196 Cosmo Bio News No 73 3 z MNT S Pa Fa YYA SNS N FAK o ES R LK HIV ES ES iPS V ReprocELL iPS Cg 131 861 87 2007 PS ES 7 je ES 00000000000000000000000000000000000000000000000000000000000000000000000
127. r TE Technologies Inc CET EE E Human Amniotic Epithelial Stem Cells HAEC 100 1x1 2 NA 41 000 Human Multipotent Cord Blood Unrestricted Somatic Stem Cells HMPC 100 1x10 cells vial 61 000 CD34 Hematopoietic Stem Cells HCD34 100 1x10 cells vial 44 000 pa CD133 or Prominin 1 Hematopoietic Stem Cells HCD133 100 1x10 cells vial 44 000 Human Adipose Derived Mesenchymal Stem Cells HMSC AD 100 1x10 cells vial Y 30 000 Human Amniotic Membrane Mesenchymal Stem Cells HMSC AM 100 1x10 cells vial 51 000 Human Bone Marrow Mesenchymal Stem Cells HMSC BM 100 1x10 cells vial Y 29 000 Human Wharton s Jelly Mesenchymal Stem Cells HMSC WJ 100 1x10 cells vial 41 000 Q Cellular Engineering Technologies Inc Cryopreservation Media CRYO MEDIA 100 100 mg 11 000 Adipogenic Differentiation Media ADI D MEDIA 450 450 m 43 000 Cardiomyocyte Differentiation Media CARDIODMEDIA100 100 mg 16 000 Chondrogenic Differentiation Media CHODMEDIA450 450 my 49 000 Endothelial Progenitor Cell Differentiation Media EPCMEDIA100 100 mg Y 35 000 Hepatocyte Like Cell Differentiation Media HLCMEDIA100 3x100 ml 68 000 Osteogenic Differentiation Media OSTDMEDIA450 450 m 42
128. roduced from 14 with permission of Elsevier G GPCR 1 GPCR Snyder 6 2 Stewart Sealfon Gonzalez MaesoO GPCH 5HTs
129. shRNA shRNA 3 009 CD 0009 CD 000 Cosmo Bio News No 73 33 ve EN A Y DSF Aa 2005 Cignal TGF 8 Notch ready to tranSduce Hypoxi a AFLA SUT SH MAD ITU TV GEERT s MAPK JNK MAPK ERK dj BTLM 9 F9 DI ERMAT H I Interferon Gamma m Type I Interferon PKC Ca p53 DNA Damage Ready to Transduce ek GFP amp 2 C EBP
130. toPT TMRM healthy MitoPTTM TMRE TMRM TMRE TMRHM na MitoPTTW TMRE TMRM e Sa 1 MitoPT TMRE TMRM l 549nm 548nm 488nm Jurkat healthy Jurkat dying MitoPTTM TMRE MitoPTTM TMRM p 510 560nm 570 620nm NikonEclipse E800
131. tt 200 nt 100 nt 1 HeLa microRNA HeLa small RNA small RNA 89 6 small _ RNA 200nt large RNA E microRNA 50 pg 600 u 200 nt 259 3x106 25 mg 5 1x109 50 mg 100 ug Noen Biotek Corp 1 EFE rxn 44 000 Mogn Biotek Corp rm 1 E rxn 45 000 mr 4C 60C 70C BERNER 196C L Jong Fr 7J av DUALmembrane mi N p fo v DUALmembrane FL
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