ハイパーサーミアおよび血管作動性薬剤併用時
Contents
1. Li 59 3 C3 H HeSlc 6 TBF_ LC 1 R 63 A2. 63
3. To RALE LV 7 A DOARRE O MIAK 5 40 44 CC 20 4 4 Hydralazine Hydrochloride Phthalazin l ylhydrazine monohydrochloride CHN HCl 196 64 9
4. 9 ANIA Re OPER KA IZ k SDRAO HS BF 9 SLE 9 42 C 10 1 ml PEGE Lic BERGE V 10 mg kg
5. 19 COR 1960 Coley Pn B z 9 L EUME E 2
6. T 1 2 3 1 ERZ pp 33 351 2 SAR 10 1 pp 19 33 1994 3 2 10 3 pp 297 1994 4
7. 0 05 ml 26 G 5x5mm 4 2 1 ml 50 mg kg 1 10 30 g 0 3 cc EL 1 cm min EL 4 3 2
8. 44 C 2 3 ml min 6 8 ml min 5 4 5 ml min 42 C 7 3 ml min 10 10 mg kg 16 4 ml min 10 10 7 ml min 6
9. cathe 2 3 pp 227 232 1992 5 T Hasegawa Y Ishiguro T Oshima Y Tana a 73 ka Potentiation of Using Hydralazine Jpn J Hyperthermic Oncology Vol 11 No 1 pp 29 33 1995 6 7 92 96 1991 7 Deway W C Hopowood L E Sapareto L A et al Cellular responses to combinations of hyperthermia and radiation Radiology 123 463 474 1977 8 pp 1 2 9 pH in Vivo AA 4 4 279 287 1988 64 Change of the amount of blood flows when com bined with a Hyperthermia and vasoactive drug Takeo HASEGAWA Ryo KUDAKA Kazuki SAITO Takashi KOUDA Yusuke ISHISOKO Hirobumi ONO Yukiko OHNO Morikazu AMANO DDepartment of Radiological Technology Faculty of Health Science Suzuka University of Medical Science 2Division of Medical Imaging Graduate School of Health Science Suzuka University of Medical
10. 1200 RPM 5 MEM 4 5 ml 10 FBS 90 MEM 100 200 gl 100 200 gl 4 25 NaCl 0 2 1 4 100 wl 60 4 25 NaCl 0 2 1 4 100 1 0 05 ml 5X10 4
11. 0 5 1 ml 2 3 10 FBS 90 MEM PBS Mg Ca CMF PBS 10 ml A 4 5 CMF PBS 0 025 2 3 ml 2 3 I LC ASAE EAST SDS U te MM amp 10 mlMEM A OM LF IZ IZ
12. pH 42 C H 10 mg kg pH aS
13. 10 20 rie D 2 blood flow ml min th tn 61 normal tissue a Ne 0 10 20 30 40 50 heat on heat off 40 42 C 43 C 5 5 1 1 3 3 4 4 ml min 10 40 C 5 3 ml min 41 C C 10 3 ml m
14. 43 C 42 C 40 41 44C 40 41 42 C 5 2 3 7 ml min 14 1 ml min 20 9 ml min 15 2 ml min 62 20 tn blood flow ml min jk time min 2 heat on heat off 42 43 C
15. SBAC 40 BE 21 SL 52 SIGMA 10 mg kg SCC VI 50mg kg 1x109 0 05 ml 4 4 1 1 10 DMSO 30 FBS 60 MEM 37 C De 10 mlMEM 10 15 ml DMSO CL 1200 RPM 5 10 FBS 90 MEM 10 ml 10ml 10 FBS 90 MEM
16. Science Key Words hyperthermia vasoactive drug blood flow Abstract We investigated change of the amount of blood flows by each temperature of heat treatment and change of the amount of blood flows by using a vasodilator Hydralazine and warm temperature together further and the influence on the warm temperature effect by using together a blood vessel operation nature medicine and warm temperature was considered We measured the blood flow at the time of 40 44 C warm temperature of subcutaneous tissue with the normal thigh of C3H mouse and an SCC VII tumor and measured change of the blood flow in Hydralazine administration Although the blood flow of a normal tissue is higher than a measurement result compared with a tumor if warm temperature is performed it will go up further However if it becomes high temperature the blood vessel in a normal tissue and a tumor tissue will be damaged and it will be thought that the fall of a blood flow takes place The blood flow of a normal tissue increased by Hydralazine medication and the blood flow of a tumor showed the decreased caused by decreased of blood flow in tumor tissue These result shows that Hyperther mia can enhanced the heat damage to tumor tissue selectively
17. 58 2 w 2 KA Aap 2 AE wat 2 1975 1 42 5 C 42 45 C
18. in 42 C C 13 4 ml min 43 C amp 44 C 5 18 1 ml min 13 0 ml min 10 10 5 ml min 6 5 ml min 42 C 42 C 42C ZOR 42 C 2 i bg 1 6 2 4 ml min 10 407C 2 3 ml min 41 C C 3 6 ml min 42 C C 6 6 ml min 43 C 9 6 ml min 44 C 10 3 0 ml min
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