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User Manual – Principal Investigators, Assignees and Departmental

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1. Add another item Graduate and Undergraduate Students and Teaching or Research Assistants Enter the User ID of all students and assistants Please enter the user s central login ID If you don t know the central login ID of the user that you re looking for please search using the central directo The users central login id is the portion of the email address before the Ducguelph ca Add another item Section 6 Animals After you click next you will be linked to Animals section of the AUP There are 3 steps to the Animal Section that must be entered Step 1 is the Animal Details Here the species strain quantity age gender accommodation experimental procedure locations and who will complete daily observations Inthe case that the species you need is not listed please contact acc uoguelph ca Animal Utilization Protocol Page 14 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Animal Details Quantity Species Strain Age Age Unit Gender Notes 12 goldfish None Both v a Accomodation Animal Housing Facility OVC Primary Healthcare Centre b Please choose the facility where the animals used on this AUP wil be housed If the facility does not appear on this Est please contact acs ucguelph ca Animal Housing Facility Room Number Lobby This field is optional if you can or would Eke to provide the specific room in the approved facility please do so here Expe
2. Please enter the user s central login ID If you don t know the central login ID of the user that you re looking for please search using the central directo A The users central login id is the portion of the email address before the ucgueiph ca Add another item Extra information Please provide additional information about the above selected procedure Remove Add another item Be careful as to which Add another item button is selected There is one for the people performing the procedure see above One to add another procedure and one to add another species very bottom of the box Step 1 Animal Information Step 2 Procedures Step 3 Analgesic and Anesthetic Drugs Name of Procedure None v Please search the list and select a listed procedure where ever possible Select general procedures and provide details in the extra information box below Select other ONLY if the general procedure is not listed If you specified other please provide further details Associated Distress or Pain Level None v Name Please enter the user s central login ID If you don t know the central login ID of the user that you re looking for please search using the central directory service The users central login id is the portion of the email address before the Duoguelph ca Add another item Extra information Please provide additional
3. Teaching Display m yAppendix 3 TEACHING DISPLAY How you are maximizing the educational gain from the animals used The expected number of participants The number of participants per animal or group of animals The participant instructor ratio Appendix 4 Surgical Procedures m yAppendix 4 SURGICAL PROCEDURES The patient preparation procedures If applicable the ventilation procedures The type of monitoring during and following surgery Animal Utilization Protocol Page 27 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Appendix 5 Genetically Modified Animals m Appendix 5 GENETICALLY MODIFIED ANIMALS Will any of these animals be genetically modified or be used in the creation of new genetically modified animals No Yes Note Standard inbred strains that carry standard mutations g agouti black or albino are not considered to be genetically modified for the purpose of this appendix Describe the species strain mutation s and or genetic modification s Outline the known or expected phenotype Outline the signs of distress pain and abnormalities Describe also your monitoring system for detecting the anatomical physiological and behavioral signs indicative of distress Please ensure you include any differences between homozygote and hetero hemi zygote animals Outline the measures to be taken to alleviate the distress pain list
4. WWW _UOGUELPH CA RESEARCH FORMS POLICIES PROCEDURES ANIMAL SHTML FOR THIS PURPOSE ALL ANIMALS USED IN THIS RESEARCH TEACHING PROJECT OR DISPLAY WILL BE CARED FOR IN ACCORDANCE WITH e THE RECOMMENDATIONS OF THE CANADIAN COUNCIL ON ANIMAL CARE e THE REQUIREMENTS OF THE ANIMALS FOR RESEARCH ACT REVISED STATUTES OF ONTARIO 1990 CHAPTER A 22 NIMAL CARE POLICY The PI must then log on go to the Review tab and complete the submission of the AUP The submission sequence is the same if a PI or Assignee fills out the bulk of the AUP PI Approval and submission to the Chair Please be sure all the information is filled in and click Next on the Appendices page to get to the Review page or click on the Review page tab if the Assignee has filled out the AUP on behalf of the PI On the review page is the PI Use Only area This is where the PI will sign the AUP and send it forward through the review process ANIMAL CARE COMMITTEE APPROVAL FOLLOWING APPROVAL A PROTOCOL NUMBER WILL BE ASSIGNED THIS NUMBER MUST BE USED WHEN ORDERING ANIMALS AND IT IS UNDERSTOOD THAT THESE ANIMALS WILL BE USED ONLY AS DESCRIBED IN THIS PROTOCOL THIS ANIMAL UTILIZATION PROTOCOL IS VALID FOR A PERIOD OF UP TO 12 MONTHS FROM THE DATE OF COMMENCEMENT THE ANIMAL CARE COMMITTEE WILL REQUEST ANNUAL REVIEWS FOR ALL PROTOCOLS THE ANIMAL CARE COMMITTEE CAN PROVIDE EXTENSIONS BEYOND THE 12 MONTH PERIOD FOR A MAXIMUM OF 4 YEARS IN TOTAL MATE
5. if you can or would Eke to provide the specific room in the approved facility please do so here Experimental Facility Area OVC Primary Healthcare Centre v Experimental Facility Area Room This field is optional if a specific room in an experimental facility is to be used and is known please fesl free to provide it here Please select the experimental arsa where the research or teaching work will occur If this is the same as the Animal Housing Facility please select the same facility for the Experimental Facility Area If the experimental facility or area does not appear on the list please con Remove Add another item Who is performing routine daily observations of the animals Both 7 If research team members or owner are responsible for daily checks please describe how it will be recorded this is done Facility staff will monitor student daily checks on fish and perform daily checks when no students are in the facility gt Admin Fields Add another item Please be sure to fill in all information for every species Step 2 of the Animals Section is filling out the source supplier information Step 1 Complete Animal fetails Step 2 Specify Animal Source s Supplier s St p 3 Complete Disposition Information Indicate the source or supplier None v None None v v Details Name of Facility of Colony Herd Flock Other AUP Number Location of Field Study or Client an
6. please do so here Experimental Facility Area OVC Primary Healthcare Centre v Pisase select the experimental area where the research or teaching work will occur If this is the same as the Animal Housing Facility please select the same facility for the Experimental Facility Area If the experimental facility or area does not appear on the list please contact acsuoguelph ca Ex perimental Facility Area Room This field is optional if a specific room in an experimental facility is to be used and is known please feel free to provide it here Who is performing routine daily observations of the animals Both v If research team members or owner are responsible for daily checks please describe how it will be recorded this is done Facility staff will monitor student daily checks on fish and perform daily checks when no students are in the facility Animal Utilization Protocol Page 15 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION If you have multiple species click add another item for the species overall Animal Details Quantity Species Strain Age Age Unit Gender 12 goldfish None v Both v Accomodation Notes Animal Housing Facility OVC Primary Healthcare Centre v Please choose the facility where the animals used on this AUP wil be housed If the facility does not appear on this Est please contact acs ucguelph ca Animal Housing Facility Room Number Lobby This field is optional
7. you will receive an email notification The email will include the AUP number a notation that comments have been made and a link to the AUP When you receive this email click on the link or log onto the system and open the relevant AUP Click on the Printer icon and open the AUP in a new window in the View mode When you scroll to the bottom of the View mode you will see the comments at the very bottom of the AUP Click on the Edit tab for the AUP and then open the relevant pages of the AUP and make the requested changes or clarifications If you do not make the requested changes for some reason please provide your rationale for why you have not made the changes in the box titled Response to ACC Comments if requested changes were NOT made please explain here under Section 1 Background in the AUP form Response to ACC comments if requested changes were NOT made please explain here If you have received requests for changes or updates from the ACC review that were NOT made to the AUP please outline here the rationale for why these changes were not made This field only needs to be filled out if requests for changes from the ACC are not being made If all changes are being made leave this field blank When all changes updates have been made go to the Review page ensure the PI signature information is still correct Review yes signature and date present and then click done at the bottom
8. 16 e Change the Review Complete box to Yes e Type your name in to the PI Signature Box e Select today s date for the PI Sign Date box Animal Utilization Protocol Page 32 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION PI Use Only By entering your name below you certify that you have read and agreed to the above declaration Review Complete Yes 7 PI Signature J Raymond PI Sign Date Date 2012 04 16 E g 2012 04 16 Then scroll to the bottom of the page and click Save A notification will then be sent to the Chair designated on the AUP and it will wait for the Chair to review and sign it electronically Once the Chair reviews signs and clicks done the AUP will then be submitted to the ACC Chair Review and Submission to the ACC When you are listed as the Chair of a Department on an AUP you will receive email notification when an AUP requires your review and signature When you log onto the system and click My AUPs Animal Utilization Protocol Create AUP Scientific Pedagogical AUP Admin My AUPs My account Gatekeeper Gatekeeper View Edit Devel My AUPs This is your dashboard for the AUP process Here you can see the AUPs that you own or are involved in The AUPs you need to review and sign as Chair will appear under the heading AUPs Pending Chair Review by Me AUPs Pending Chair Review By Me AUP Project Name PI Status Creation Dat
9. a quick summary of your qualifications E mail address talel wahabi gmail com A valid e mail address All e mails from the system will be sent to this address The e mail address is not made public and will only be used if you wish to receive a new password or wish to receive certain news or notifications by e mail Password Password strength Confirm password To change the current user password enter the new password in both fields Picture ee Upload picture Choose File No file chosen Your virtual face or picture Pictures larger than 1024x1024 pixels will be scaled down v Locale settings Time zone America Toronto Tuesday November 15 2011 08 53 0500 Select the desired local time and time zone Dates and times throughout this site will be displayed using this time zone Save 2011 University of Guelph Animal Utilization Protocol Page 6 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION How to Login with a University of Guelph Central Login ID For users with University of Guelph account there is no need to register just login with your central login ID Your password is the same as your central login ID and cannot be changed in this system UNIVERSITY Animal Utilization Protocol 2 GUELPH To get started please log in to manage your AUPs Create new account Log in Request new password User account Username admin Enter your A
10. administered in 1 injection only If the use of Pristane is proposed it should be justified to the ACC and the volume limited to 0 2 mi Hybridoma Implantation Volume of hybridoma cells to be injected NOTE Up to 2 x 106 hybridoma cells in a maximum volume of 1 0 mi may be injected IP Ascites Production No Yes Specify amount required NOTE Ascites in mice is allowed to proceed to no greater than 20 of body weight gain and mice must be monitored twice daily once abdominal swelling is noted The ACC requests that all harvests be terminal and preceded with euthanasia e g using CO2 to minimi ize distress and discomfort to the mice 4 Finalization and Submission Review Section After you click next you will be linked to Review section of the AUP This section is where the PI will review the AUP and sign off on it prior to submission to the Departmental Chair for signature and then the ACC for review processing If an Assignee has completed the form on behalf of the PI the Assignee will complete the form to the Appendices Then on the Review page the Assignee will click Done or Save The PI has the power to edit anything in the AUP To do that he just needs to click on edit change the information and then click save Animal Utilization Protocol Page 31 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Section 1 Background Section 5 Personnel S
11. do I renew my AUP After AUP is approved to renew please select AUP and click renew Animal Utilization Protocol View Ammend Copy Devel AUP 1176 Background To Status Approved Project Name AUP Help Project Timeline Tuesday December 13 2011 to Tuesday December 11 2012 Personnel Principal Investigator or Instructor admin Assignee abolinde Chair of Department abolinde Does your project involve any hazardous materials No Click on the Submit button after you click the Renew tab The AUP is then submitted to the system for renewal view Edit Revisions Amend Copy AUP 1218 iit to renew this AUP Compare Devel The AUP will come up in the View screen Click the Edit tab to change and update the AUP Make any updates and changes throughout the AUP that are required Any field can be updated at the time of renewal And fill out Appendix 8 Renewals in Section 9 Appendices Be sure to fill out all questions in the appendix including a summary of the changes made to the AUP form for the renewal When finished Click on the Review page and sign and submit the AUP the same as the original AUP Animal Utilization Protocol Page 39 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION How do I amend my AUP After an AUP gets approved to amend please select the AUP and click on the Edit tab Then click on the Amend tab and click Su
12. induction maintaining the surgical plane or during recovery information about why the drug is the most acceptable option If the drug is an alternative to another drug etc When all species procedures and drugs have been entered please continue to fill out the sections in Section 8 until all information fields are complete v Overall Procedure Details Specify the criteria that will be used to assess the level of analgesia anaesthesia required Give a sequential description of the use of animals in this teaching exercise or research project What is the highest distress or pain level associated with any of your procedures None v Specify the frequency of observations and methods for monitoring the condition of the animals Animal Utilization Protocol Page 25 of 40 November 10 2011 CCS WEB SOLUTION Please attach assessment sheets if this is available Add a new file Browse Upload Files must be less than 20 MB Allowed file types pdf doc docx List personnel who will be monitoring the animals FUNCTIONAL SPECIFICATION Please enter the user s central login ID If you don t know the central login ID of the user that you re looking for please search using the central directory service The users central login id is the portion of the email address before the uoguelph ca Add another item Explain refinements that have been made to minimize pain distress and or discomfort to the anim
13. of Department Use Only By entering your name below you certify that you have read and agreed to the above declaration Review Complete None v If you select No the AUP will be returned to the PI for changes Please use the Chair Comments box to indicate why the AUP cannot be signed If you select Yes the AUP is complete and can be submitted to the ACC for review If you select Yes add any comments you wish optional in the Chair Comments box then type your name in the Chair Signature box and select the date in the Chair Sign Date box Switch to plain text editor More information about text formats Chair Signature Chair Sign Date g 2012 04 17 Animal Utilization Protocol Page 36 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Then you must scroll to the bottom of the page and click Done This will either send the AUP back to the PI for further changes No is selected or onto the ACC for review Yes is selected lt Previous Save Responding to ACC Review Comments and Requests for Changes Updates When your AUP is submitted to the ACC after the Chair Dean Director has signed and submitted the AUP it will continue through the ACC review process There are points in the review where the AUP may be commented on by ACC reviewers and changes or clarifications requested When your AUP has been commented on by the ACC
14. screen appears click install Version 9 will install and you then have to log off your computer and log on again or restart your computer if you do not have a user log on for the upgrade to take effect Animal Utilization Protocol Page 40 of 40 November 10 2011
15. CCS Computing amp Communications Services User Manual Principal Investigators Assignees and Departmental Chairs Animal Utilization Protocol Joanne Raymond and Talel Wahabi Animal Care Services and CCS Web Solutions CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Table of Contents Roles Main Functionalities 1 Registration Front Page View How to Create a New Account Non University of Guelph How to Login with a University of Guelph Central Login ID User Profile 2 How to Become a Principal Investigator PI 3 How to Create an AUP How to Add Non Registered Personnel in the System Designating an Assignee Section 1 Background Section 2 Lay Summary Section 3 Funding Information and Scientific or Educational Merit Review Section 4 Hazards Section 5 Personnel Section 6 Animals Section 7 Experimental and or Animal Use Endpoints Section 8 Procedures Section 9 Appendices 4 Finalization and Submission Animal Utilization Protocol Page 2 of 40 November 10 2011 10 10 11 12 12 13 13 14 21 21 26 31 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Review Section 31 PI Approval and Submission to the Chair 32 Chair Review and Submission to the ACC 33 To Comment or Sign Off as Chair 34 Responding to the ACC Review Comments and Requests for Changes Updates on 37 the AUP 5 Viewing and Renewing Amending AUPs 38 How can Check the List of My AUPs includes AUPs you are listed on a
16. Fill out all fields under the Address Heading Owner s name Farm Facility name and address information Details Name of Facility of Colony Herd Flock Other AUP Number Location of Field Study or Client animals to be used Address Donor or Owner of Proerdte Facility Name Company or Private Farm Facility Name Street City Postal Code Province State Country Phone Number None None Y U of G Colony Herd Flock Fill in the Field titled Name of Facility of Colony Herd Flock Name of Facility of Colony Herd Flock Other AUF Number Location of Field Study or Client animals to be used Address Donor or Owner of Private Facility Name Company or Private Farm Facility Name Street City Postal Code Province State Country Phone Number None Y None Y Animal Utilization Protocol Page 18 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Wildlife Field Studies Fill in the Field titled Location of Field Study Details Location of Field Study or Client animals to be used Name of Facility of Colony Herd Flock Other AUP Number Address Donor or Owner of Private Facility Name Company or Private Farm Facility Name Street City Postal Code Province State Country Phone Number None Y None Y If you have multiple sources for the species click Add another item to add another source Step 1 Complete Animal Details Step 2 Specif
17. Getting info for Chair portion of manual Project Category Research Project Timeline Tuesday April 17 2012 to Tuesday April 16 2013 Purpose of Animal Use Studies of a fundamental nature in sciences relating to essential structure or function i e biology psychology biochemistry pharmacology physiology behaviour etc Classification Acute Utilizing an animal for a brief period less than 24 hrs followed by euthanasia or return of the animal to source or humanely killing an animal upon receipt or after a brief housing period during which time no manipulations other than standard management procedures are performed i e anaesthetized without recovery euthanised for tissue collection etc For RESEARCH projects is this a pilot study No Section 2 Lay Summary Public Relations Research problem s or instructional principle s this project addresses Background and Objectives Submitting an AUP to get screen shots for Chair stuff Anticipated impact specific potential benefits to human and or animal welfare Relevance of Research or Instruction Getting manuals ready Additionally you can open the View or Print View in a new window by right clicking on View or on the printer icon and selecting Open in a new window This will allow you to comment on the AUP in the Review see below for details on how to do this at the same time as viewing the AUP information To Comment and or Sign off on an AUP as Chai
18. Please provide a summary of all results pertaining to the procedures used as follows Morbidity and mortality of all species used in the study i e in capture transportation and refinement s made to prevent this If applicable the number of accidental non target species catches and refinement s made to prevent this Plazse be prepared to provide this information If you have any questions please contact the Director Animal Care Services at axt 543205 Animal Utilization Protocol Page 29 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Appendix 7 Antibody Production Polyclonal Antibody Production m Appendix 7 ANTIBODY PRODUCTION Antibody Production Type Polyclonal v POLYCLONAL ANTIBODY PRODUCTION v Please describe the method used for purification of the antigens to be injected Will agarose beads be used No Yes only allowed once Will acrylamide gel strips be used No Yes only allowed once NOTE Use of antigens from cut up bands of acrylamide should be avoided Antigens within these SDS PAGE separated bands can easily be extracted by slectroslution and used in immunization Antigens on immunoblots obtained by blotting the gels on nitrocellulose membranes to allow transfer of the antigens to the membranes are not easily extracted The nylon backed nitrocellulose membranes g imobilon or flexible membranes are not easily ground and
19. RIAL TRANSFER AGREEMENTS MTAS MTAs may be required to protect the nghts of the parties involved in the exchange of biological materials for research purposes For advice and assistance in this regard please contact the Administrative Assistant Business Development Office 519 824 4120 ext 58878 DECLARATION THIS ANIMAL UTILIZATION PROTOCOL ACCURATELY DESCRIBES ALL THE PROPOSED ANIMAL USE IT WILL BE KEPT CURRENT AND WILL BE MODIFIED ONLY AFTER OBTAINING THE APPROVAL OF THE ANIMAL CARE COMMITTEE ALL PROCEDURES WILL BE CARRIED OUT BY PERSONNEL LISTED IN QF9 WHO ARE TRAINED AND COMPETENT IN USING APPROVED TECHNIQUES AN ANIMAL INCIDENT REPORT WILL BE FAXED TO THE DIRECTOR ANIMAL CARE SERVICES WITHIN 24 HOURS OF ANY UNEXPECTED PROBLEMS OR COMPLICATIONS INVOLVING ANIMAL HEALTH AND WELLBEING IN THIS STUDY AN ANIMAL INCIDENT REPORT IS AVAILABLE HTTP WWW UOGUELPH CA RESEARCH FORMS POLICIES PROCEDURES ANIMAL SHTML FOR THIS PURPOSE ALL ANIMALS USED IN THIS RESEARCH TEACHING PROJECT OR DISPLAY WILL BE CARED FOR IN ACCORDANCE WITH THE RECOMMENDATIONS OF THE CANADIAN COUNCIL ON ANIMAL CARE o THE REQUIREMENTS OF THE ANIMALS FOR RESEARCH ACT REVISED STATUTES OF ONTARIO 1990 CHAPTER A 22 Ve 7 ANIMAL CARE POLICY Dew SSL PI Use Only By entering your name below you certify ti ou have read and agreed to the above declaration Review Complete Non v PI Signature PI Sign Date Date Eg 2012 04
20. age as this will remove the entire species Continue filling out the fields in the Animal Section Explain how the total number of animals to be used was determined Attach files to explain if necessary Add a new file Choose File No file chosen Upload Files must be less than 20 MB Allowed file types txt pdf doc docx odf Indicate consideration given to reduce the use of animals Describe the characteristics of the animal that make the species or strain appropriate for the research or teaching objectives Attach files if necessary Add a new file Choose File No file chosen Upload Files must be less than 20 MB Allowed file types txt pdf doc docx odf If you attach any supporting documentation Please be sure to click upload after you choose your file s Animal Utilization Protocol Page 20 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Section 7 Experimental and or Animal Use Endpoint Fill in the fields with the appropriate information Section 7 Experimental and or Animal Use Endpoint Expected clinical conditions or abnormalities None Indicate any clinical conditions or abnormalities expected or that could arise as a result of the proposed study or teaching exercise e g behavioural changes such as increased grooming vocalization or postural changes or physical abnormalities such as anorexia dehydration diarrhea etc Removal Criteria Mouse is no longer normal a
21. als i e modified procedures If you attach any supporting documentation please ensure you click upload after selecting your files Section 9 Appendices After you click next you will be linked to Appendices section of the AUP Please check all the appendices you need The associated questions for each appendix checked will open to be answered Please respond to all questions except those indicated for annual renewals unless you are submitting an annual renewal in which case please fill in any changes to the appendix questions and the annual renewal questions View Edit Revisions Compare Devel Section 1 Background Section 5 Personnel Section 6 Animals Section 8 Procedures Section 9 Appendices Review Status Initial ACC Review Section 9 Appendices Appendices Appendix 1 CCAC Categories of Invasiveness in Animal Experiments A E Appendix 2 CCAC Social amp Behavioural Requirements of Experimental Animals Additional Information required by the Canadian Council on Animal Care T Appendix 3 Teaching Display Appendix 4 Surgical Procedures D Appendix 5 Genetically Modified Animals Appendix 6 Wildlife Field Studies Appendix 7 Antibody Production For studies involving the following additional forms must be completed as appendices to your Animal Utilization Protocol Animal Utilization Protocol Page 26 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Appendix 3
22. are not suitable for antigen delivery in immunization The extended antigens may be extracted or ground up with nitrocellulose which is less harmful to the animal only allowed once If other method please provide details Adjuvant No Yes NOTE The use of Freund s Complete Adjuvant FCA can cause severe side effects and is only approved for the most problematic immunization situations it may be used only when small amounts of soluble immunogens are available and only as the primary injection The researcher must show scientific Refinement tip To decrease adverse reactions dilute the concentration of Mycobacterium in the FCA to 0 1 mg ml by using mineral oil Injection Routes and Dosage gt Refer to CCAC guidelines on antibody production Appendix B immunization Recommended Routes and Volumes Volume of Inoculum per site gt 4 CCAC guidelines on antibody production Appendix E Number of injection sites gt Schedule for injections and blood sampling NOTE if the first immunization is performed without a depot forming adjuvant e g FIA or alum based adjuvants the antibody titre will usually peak 2 2 weeks after immunization When a depot forming adjuvant is used a booster injection can follow at least 4 weeks after the first immunization Multiple boosters should not require the use of adjuvant CCAC guidelines on antibody production Polyclonal Antibody Production Sectio
23. bmit View Edit Revisions Copy Renew Compare Devel Click submit to amend this AUP You will then see the following screen This AUP has successfully been re opened for amendment You or your assignee may now edit this AUP to begin the amendment process View Revisions Compare Devel AUP 1248 Section 1 Background Status In Progress Project Name Getting info for Chair portion of manual Project Category Research Project Timeline Tuesday April 17 2012 to Tuesday April 16 2013 Purpose of Animal Use Click on the Edit tab and the PI or their Assignee can make any changes to the form When complete the PI must sign and date the form on the Review tab The AUP will then be submitted Use of Internet Explorer as a Browser to View the System When using Internet Explorer as your primary browser it is important to note that some functions of this system do not function correctly on versions of 7 or earlier If you use a version of Internet Explorer that is 7 or older we recommend updating the browser to Internet Explorer version 9 to ensure the system functions correctly For example if you have an older browser you may notice that drop down lists under lap information below the question To update your browser go to the following website http ie9 discoverbing com intl en_ca index html Click on Download Now then click run or Allow to download the software When the download
24. ctives Submitting an AUP to get screen shots for Chair stuff Anticipated impact specific potential benefits to human and or animal welfare Relevance of Research or Instruction Getting manuals ready Section 3 Funding Information and Scientific or Educational Merit Review Section 3 Funding Information and Scientific or Educational Merit Review Has funding been approved for this study Teaching Display General Operating Protocols No funding required v Granting Agencies None v If you specified other please provide further details Funding Source s Title of Grant Grant Timeline Start Date End Date E g 2012 05 23 E g 2012 05 23 Attachments Please attach relevant portions of the grant s or applications s that provide background information on the research problem as well as detailed animal care and procedural information Add a new file liplond Files must be less than 20 MB Allowed file types pdf doc docx Please attach a copy of the internal University review letter s Add a new file Browse Upload Files must be less than 20 MB Allowed file types pdf doc docx Extra Comments or Recommendations Please include any additional information related to your peer or pedagogical review process i e suggested reviewers motes on outstanding processes etc Animal Utilization Protocol Page 12 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Whe
25. cument 1 Registration Front Page View Roles Involved Any user has access to the front page Description The front page offers Login Create new account or Request new password Please note if you have a University of Guelph email account you don t need to create a new account simply login with your University of Guelph central login ID same as your email account If Animal Utilization Protocol Page 4 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION you have a University of Guelph central login ID please skip down to page 6 How to login with a University of Guelph account How to create new Account Non University of Guelph Users without a University of Guelph account need to register and then confirm by a following a link received on their e mail and updating their personal information Animal Utilization Protocol GUEL E as S h Web Directory Library To get started please log in to manage your AUPs Create new account Log in Request new password Home Common Name Username Spaces are allowed punctuation is not allowed except for periods hyphens apostrophes and underscores E mail address A valid e mail address All e mails from the system will be sent to this address The e mail address is not made public and will only be used if you wish to receive a new password or wish to receive certain news or notifications by e mail Create new account 2011 Universi
26. e Updated date 1218 Getting info for Chair portion of manual AUP Student Chair Review in Progress 2012 04 17 09 50 Tuesday April 17 2012 09 55 Access the AUP to sign it Click on the AUP Animal Utilization Protocol Page 33 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION AUPs Pending Chair Review By Me AUP Project Name Pl Status Creation Date Updated date Getting info for Chair portion of manual AUP Student Chair Review in Progress 2012 04 17 09 50 Tuesday April 17 2012 09 55 A view of the AUP will open View Edit Revisions Compare Devel AUP 1218 Section 1 Background Status Chair Review in Progress Project Name Getting info for Chair portion of manual Project Category Research Project Timeline Tuesday April 17 2012 to Tuesday April 16 2013 Purpose of Animal Use Studies of a fundamental nature in sciences relating to essential structure or function i e biology psychology biochemistry pharmacology physiology behaviour etc Classification Acute Utilizing an animal for a brief period less than 24 hrs followed by euthanasia or return of the animal to source or humanely killing an animal upon Aceipt or after a brief housing You can scroll through here to review the AUP You can also click on the printer4con to open a different view with more delineation in the text USUELPH Y AUP 1218 Section 1 Background Status Chair Review in Progress Project Name
27. e looking for please search using the central directory The users central login id is the portion of the email address before the Ducguelph ca Associate s Please enter the user s central login ID If you don t know the central login ID of the user that you re looking for please search using the central directory service The users central login id is the portion of the email address before the Ducguelph cz Add another item Technical Staff Add the User ID of all technical staff or technical specialists involved in the AUP Also be sure to add the facility User ID for the accomodation and experimental locations Ses the Animal Care Services website for a list of up to date facility User IDs Sernce Please enter the user s central login ID If you don t know the central login ID of the user that you re looking for please search using the central directo The users central login id is the portion of the email address before the Ducguelph ca Add another item Designated Veterinarian s The veterinarian who will be attending to the animal health during this project This person cannot be the PI or other person associated with the AUP work sence Please enter the user s central login ID Hf you don t know the central login ID of the user that you re looking for please search using the central directo The users central login id is the portion of the email address before the Ducguelph ca
28. ection 6 Animals Section 8 Procedures Section 9 Appendices Review Review ANIMAL CARE COMMITTEE APPROVAL FOLLOWING APPROVAL A PROTOCOL NUMBER WILL BE ASSIGNED THIS NUMBER MUST BE USED WHEN ORDERING ANIMALS AND IT IS UNDERSTOOD THAT THESE ANIMALS WILL BE USED ONLY AS DESCRIBED IN THIS PROTOCOL THIS ANIMAL UTILIZATION PROTOCOL IS VALID FOR A PERIOD OF UP TO 12 MONTHS FROM THE DATE OF COMMENCEMENT THE ANIMAL CARE COMMITTEE WILL REQUEST ANNUAL REVIEWS FOR ALL PROTOCOLS THE ANIMAL CARE COMMITTEE CAN PROVIDE EXTENSIONS BEYOND THE 12 MONTH PERIOD FOR A MAXIMUM OF 4 YEARS IN TOTAL MATERIAL TRANSFER AGREEMENTS MTAS MTAs may be required to protect the rights of the parties involved in the exchange of biological materials for research purposes For advice and assistance in this regard please contact the Administrative Assistant Business Development Office 519 824 4120 ext 58878 DECLARATION THIS ANIMAL UTILIZATION PROTOCOL ACCURATELY DESCRIBES ALL THE PROPOSED ANIMAL USE IT WILL BE KEPT CURRENT AND WILL BE MODIFIED ONLY AFTER OBTAINING THE APPROVAL OF THE ANIMAL CARE COMMITTEE ALL PROCEDURES WILL BE CARRIED OUT BY PERSONNEL LISTED IN Q 9 WHO ARE TRAINED AND COMPETENT IN USING APPROVED TECHNIQUES AN ANIMAL INCIDENT REPORT WILL BE FAXED TO THE DIRECTOR ANIMAL CARE SERVICES WITHIN 24 HOURS OF ANY UNEXPECTED PROBLEMS OR COMPLICATIONS INVOLVING ANIMAL HEALTH AND WELLBEING IN THIS STUDY AN ANIMAL INCIDENT REPORT IS AVAILABLE HTTP
29. ed above Outline any potential health consequences to those working with the animals Outline any special containment and security procedures required in the animal facility where these animals are to be held Are these animals rodents No Yes Containment requirements No when will this be done 5 gt Yes provide explanation of the requirements to be met or a copy of the documentation Have the containment requirements necessary for the generation of these genetically modified animals been ascertained to ensure compliance with the Environmental Protection Act or related legislation When will this be done Animal Utilization Protocol Page 28 of 40 November 10 2011 CCS WEB SOLUTION Appendix 6 Wildlife Field Studies m Appendix 6 WILDLIFE FIELD STUDIES FUNCTIONAL SPECIFICATION If traps are to be used specify The type of trap None hd The potential for injury from the trap The monitoring frequency The procedures if lactating females are trapped Specify the locations where these studies will occur List permits that have been applied for and or received Specify the type or degree of potential ecological disruption expected i e consequences to reproduction survival of animals studied Annual Review Field Studies Fields required for renewal The following questions will be asked of you at the annual review of this Animal Utilization Protocol
30. ifications are e t can be viewed by ACS ACC staff to ensure training qualifications have been met e t can be searched by ACS staff to find all researchers using particular species or areas of study e t can be searched by the Scientific Merit Gatekeeper to find reviewers who specialize in an area of study or species Animal Utilization Protocol searc h Web Directory Library Home Create AUP My AUPs My account Log out View Edit Devel Talel Wahabi Last Name Wahabi First Name Talel Common Name Talel Wahabi Department CCS Web Solutions Phone 52869 Qualifications Computer Sciences Please provide a quick summary of your qualifications Current password The password cannot be changed using this website Note It s the user responsibility to update his her personal information 2 How to Become a Principal Investigator PI Roles Involved Participant authenticated user and the Principal Investigator PI Please take in consideration the next steps for your application Step 1 Click on Become a PI Animal Utilization Protocol Page 8 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Animal Utilization Protocol search Web Directory Library Home Become a PI My AUPs My account Log out Welcome Please take a moment to fill out your user profile Submit a request to become a PI 2011 University of Guelph After you click submit you receive
31. imals to be used Address Donor or Owner of Private Facility Name Company or Private Farm Facility Name Street City Postal Code Province State Country Phone Number Add another item Animal Utilization Protocol Page 16 of 40 Add another item J November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Select the source of the animals from the drop down list Step 1 Complete Animal Details Step 2 Specify Animal Source s Supplier s Step 3 Complete Disposition Information Indicate the source or supplidr None v Details Name of Facility of Colony Herd Flock Other AUP Number Location of Field Study or Client animals to be used r Address Donor or Owner of Private Facility Name Company or Private Farm Facility Name Street City Postal Code Province State Country Phone Number None v None v Add another item Remove Add another item The remainder of the fields are required based on the source and may not be required for each type of source Please fill out according to the directions below Client Owned fill out the field Location of Field Study or Client animals to be used by entering the name of the facility where the client animals are located e g OVC Primary HealthCare Centre Details Name of Facility of Colony Herd Flock Other AUP Number Location of Field Study or Client animals to be used Address D
32. in id is the portion of the email address before the uoguelph ca As Chair click on the Review tab at the end of the section headings View Edit Revisions Compare Devel Section 1 Background Section 5 Personnel Section 8 Procedures Section 9 Appendices Status Chair Review in Progress v Section 1 Background Principal Investigator or Instructor laupstudent fuid 76 Please enter the user s central login ID If you don t know the central login ID of the user that you re looking for please search using the central directory service The users central login id is the portion of the email address before the uoguelph ca Animal Utilization Protocol Page 35 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION The Declaration will appear Scroll down to see the Chair Signature area Chair of Department Use Only By entering your name below you certify that you have read and agreed to the above declaration Review Complete None v Chair Comments Q E Li l o E ie E Source Be Gy ae ae aa im sian B F U ate Xo ee Hl i ir I iil Kil Il a A a Switch to plain text editor More information about text formats Text format Filtered HTML v Chair Signature Chair Sign Date E g 2012 04 17 When you are ready to indicate if the AUP is complete or not change the Review Complete box to Yes or No Chair
33. information about the above selected procedure Remove Add another item New Procedure same species New Species and procedures Animal Utilization Protocol Page 24 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Step 3 if applicable please add in the relevant information for the drugs to be used in the procedures listed in Step 2 Step 1 Animal Information Step 2 Procedu es Step 3 Analgesic and Anesthetic Drugs Drug Dosage Dosage Unit Other Dosage Unit None v Route None v Procedure drug is for and additional Details Please indicate which procedure s this drug will be used for and provide any additional details about the drug e g frequency of administration specific properties etc Remove Add another item Remove Add another item New drug in same species New Species procedures and drugs Please note that this section is for Anaesthetic and Analgesic drugs to be given in the course of the experimental work or for general care of the animals Experimental substances and drugs should be listed in the procedures section as administration of substances with relevant details provided in the details bar The Additional details box in the section is for any relevant information to be provided about the Anesthetics or analgesics to be used e g for specific times in the procedures
34. n 7 Amount of blood per test sample e g pre amp post immunization Blood collection techniques used for harvesting blood NOTE The maximum blood volume removed should not exceed 10 of the total blood volume of the animal if collected every 2 weeks and not more than 15 of the total blood volume if collected every 4 weeks CCAC Guidelines on antibody production Polyclonal Antibody Production Section 8 Intermittent blood collection No Yes Specify amount per collection Terminal Bleed No Yes Will animals be group housed No Yes Will tattooing be performed for identification purposes No Yes Who will be responsible for record keeping NOTE The immunization record should include the agent with reference to generation source purification route site or sites volume date of injection and body weight of the animals CCAC guidelines on antibody production Polyclonal Antibody Production Section 9 Please enter the user s central login ID If you don t know the central login ID of the user that you re looking for please search using the central directory service The users central login id is the portion of the email address before the Ducgueiph ca Animal Utilization Protocol Page 30 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Appendix 7 Antibody Production Monoclonal Antibody Pr
35. n you upload a file be sure to click upload after you select the file from its saved location In case you need more items just click on add another item Section 4 Hazards ySection 4 Hazards Does your project involve any hazardous materials or situations Yes No Eg Projects involving radio isotopes carcinogens chemical agents pathogens or possibility of electroshock Radio Isotope s Carcinogen s Chemical s Pathogen s Pathogen contagious to None Other eg Slectrosmock Specify what special animal care or human precautions e g protective equipment is required because of the hazard s involved EHS Approval Date Date Eg 2012 04 15 After you click next the AUP will be created and you will be linked to the edit application to start fill it in Section 5 Personnel The next portion of the form is the Personnel section Here you will list all persons involved with the AUP Please note Technical staff for all facilities to be used should be listed in the Technical Staff section of the AUP Each facility will have a generic ID to be added to the Technical Staff section as well These generic IDs will be available on the Animal Care Services website and must be added to each AUP under the appropriate sections In the case of large facilities where multiple technicians may work on the AUP please list the lead technician or foreman as appropriate Examples of such facilities include the Ce
36. nd can be contacted please contact them and request they log into the system and registered after which they can be added to the AUP 2 If the individual is an external individual does not have access to a computer to log in or cannot be contacted by the PI or assignee a user ID may be created administratively In this case please email acc uoguelph ca with the person s name position and email address if available to ask that an account be created Once the account is created the person can be added to the AUP Click Create AUP Animal Utilization Protocol v Welcome Please take a moment to fill out your user profile View Edit Devel Talel Wahabi Last Name Wahabi First Name Talel Common Name Talel Wahabi History Member for 4 min 22 sec 2011 University of Guelph The screen below will then come up Fill in the information appropriately Click save and ensure the file saves so that it can be left and completed later if necessary Designating an Assignee Please note If you are a PI who is initiating an AUP for an assignee to complete you must fill in the minimal following information save the AUP and then the assignee can log in and complete the form on your behalf Animal Utilization Protocol Page 10 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Please note It is not required that an assignee be designated on an AUP This is an option for those Pis
37. nimal Utilization Protocol username Enter the password that accompanies your username 2011 University of Guelph User Profile On your first login and any time information changes please your personal information which includes your training and qualifications To access your profile to update click my account and then click edit to modify In your profile the following information is included e Firstname e Last name e Common name this is the name that will be displayed in the system for people to select when you are added to an AUP e Department e Phone can be your University extension e Qualifications this is any qualifications training continuing education professional designations organizational memberships etc that may apply to your animal research in terms of qualifications and training Please include dates on any information included to ensure only up to date information is considered e Species this is are the species you work with in research If you work with more than one species please separate species with semi colons e Area of Research this is your general area of focus for your research and may be similar to your department Animal Utilization Protocol Page 7 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Your user profile information has several uses within this system e It can be viewed by any other member of an AUP to see what individual qual
38. ntral Animal Facility Arkell Research Station Ponsonby Research Station and the Elora Research Station This applies ONLY to those facilities with dedicated animal care staff and CAN NOT be done if primary care for the animals is provided by research team members In the event primary care is given by research team members all persons involved must be listed separately Additionally all persons performing specific AUP related procedures must be listed individually in the form To add multiple people in each section click Add another item at the bottom of the relevant section to add additional personnel Animal Utilization Protocol Page 13 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Section 5 Personnel Chair of Department raymond uid 73 Please add in the appropriate departmental chair user ID The list of up to date Chair IDs can be found on the Animal Care Services Website Pisase enter the user s central login ID if you don t know the central login ID of the user that you re looking for please search using the central directory The users central login id is the portion of the email address before the Duogueiph ca Designated Emergency Contact s jaupstudent uid 76 Please enter the names of the people associated with the AUP who should be contacted in the event of an emergency Please enter the user s central login ID if you don t know the central login ID of the user that you r
39. oduction m Appendix 7 ANTIBODY PRODUCTION Antibody Production Type Monoclonal v MONOCLONAL ANTIBODY mAbs PRODUCTION NOTE Every attempt should be made to use an in vitro method of production of monoclonal antibodies Therefore any proposed production of monoclonal antibodies using the ascites method requires justification by the investigator i e show that a substantial effort has been made to adapt the hybridoma to a culture system Is this a new hybridoma No Yes if so please test a new hybridoma in a small pilot study involving 2 2 animals to ensure that an antibody will be produced Remember to include this in the AUP Has the hybridoma been tested Yes No but this will be done later No this won t be done Has the hybridoma been tested for the presence of adventitious viral and mycoplasma agents prior to use for in vivo propagation of monoclonal antibodies NOTE The typical testing method is the Mouse Antibody Production MAP test which involves injecting a sample of tissue in question into mice and after 3 4 weeks euthanizing the mice to run serological tests for a panel of known adventitious agents Such tests are performed by Charles River Laboratories PCR may be a viable alternative test Priming Specify priming agent and volume NOTE Freund s incomplete Adjuvant or other less invasive adjuvant should be used as the intraperitoneal primin g agent with a maximum volume of 0 2 mi FIA
40. of the page The AUP will then be sent back to the ACC for review of your updates and changes If questions are asked more than once the new comments and questions will appear below the original questions at the bottom of the View of the AUP Animal Utilization Protocol Page 37 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION 5 Viewing and Renewing Amending AUPs How can I check the list of My AUPs Includes AUPs you are listed on as any role PI Associate Technical Chair Etc To check the list of AUP you are involved in please login to the system and then click My AUPs link you will get access to the list of all your AUPs you can check their status by filtering them er Animal Utilization Protocol UG TELPH search We Create AUP My AUPs My account Log out View Devel My AUPs This is your dashboard for the AUP process Here you can see the AUPs that you own or are involved in Filter By Status Status Creation Date Updated date 1176 AUP Help In Progress 2011 12 13 06 49 Tuesday December 13 2011 06 49 AUPs I m Involved In Filter By Status Any z Apply AUP Project Name Status Creation Date Updated date 1176 AUP Help In Progress 2011 12 13 06 49 Tuesday December 13 2011 06 49 Create a New AUP Create an AUP 2011 University of Guelph Animal Utilization Protocol Page 38 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION How
41. onor or Owner of Private Facility Name Company or Private Farm Facility Name Street City Postal Code Province State Country Phone Number None Y None Y Donated Fill out the Donor name field and their address information Details Name of Facility of Colony Herd Flock Other AUP Number Location of Field Study or Client animals to be used q Donor or Owner of Private Facility Name Jompany or Private Farm Facility Name Street City Province State Country Phone Number None Y None Y Animal Utilization Protocol Page 17 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION From Another AUP Fill out the Other AUP Number field Please note that the AUP s listed must be current and active If it will be to an upcoming AUP please indicate this and provide the Pl s name Details Name of Facility of Colony Herd Flock Other AUP Number Location of Field Study or Client animals to be used Address Donor or Owner of Private Facility Name Company or Private Farm Facility Name Street City Postal Code Province State Country Phone Number None Y None Y Purchased Fill out the Company name field and address information Details Name of Facility of Colony Herd Flock Other AUF Number Location of Field Study or Client animals to be used Address Donor or Owner of Private Facility Name Company or Private Farm Facility Name Postal Code Privately Owned
42. r When you have the AUP open in the View tab click on the Edit tab beside the View tab Animal Utilization Protocol Page 34 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION View AUP Revisions Compare Devel Section 1 Background Status Chair Review in Progress Project Name Getting info for Chair portion of manual Project Category Research Project Timeline Tuesday April 17 2012 to Tuesday April 16 2013 Purpose of Animal Use Studies of a fundamental nature in sciences relating to essential structure or function i e biology psychology biochemistry pharmacology physiology behaviour etc Classification Acute Utilizing an animal for a brief period less than 24 hrs followed by euthanasia or return of the animal to source or humanely killing an animal upon receipt or after a brief housing You will now get an edit view of the AUP This is the forum for the PI or Assignee to edit or change their AUP View Edit Revisions Compare Devel Section 1 Background Section 5 Personnel Section 6 Animals Section 8 Procedures Section 9 Appendices Review Status Chair Review in Progress v Section 1 Background Principal Investigator or Instructor laupstudent fuid 76 Please enter the user s central login ID If you don t know the central login ID of the user that you re looking for please search using the central directory service The users central log
43. re None v Pisase search the list and select a listed procedure where ever possible Select general procedures and provide details in the extra information box below Select other ONLY if the general procedure is not listed If you specified other please provide further details Associated Distress or Pain Level None v Name Pisase enter the user s central login ID If you don t know the central See_users central login id is the portion of the email address Soff Ggin ID of the user that you re looking for please search using the central directory service the ucgueiph ca Remove Add another item Extra information Pisase provide additional information about the above selected procedure aan Add another item Animal Utilization Protocol Page 23 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION To add an additional person who is performing the procedure click Add another item Step 1 Animal Information Step 2 Procedures Step 3 Analgesic and Anesthetic Drugs Name of Procedure None Please search the list and select a listed procedure where ever possible Select general procedures and provide details in the extra information box below Select other ONLY if the general procedure is not listed If you specified other please provide further details Associated Distress or Pain Level None v Name
44. rimental Facility Area OVC Primary Healthcare Centre v Please select the experimental arsa where the research or teaching work will occur If this is the same as the Animal Housing Facility please select the same facility for the Experimental Facility Area If the experimental facility or area does not appear on the list please contact acs ucguelph ca Experimental Facility Area Room This field is optional if a specific room in an experimental facility is to be used and is known please fee free to provide it here Who is performing routine daily observations of the animals Both P If research team members or owner are responsible for daily checks please describe how it will be recorded this is done Facility staff will monitor student daily checks on fish and perform daily checks when no students are in the facility Fill in all information about the species If the project will occur in multiple locations click Add another item for the accommodation section Animal Details Quantity Species Strain Age Age Unit Gender Notes 12 jgoldfish None v Both v a Accomodation Animal Housing Facility OVC Primary Healthcare Centre v Please choose the facility where the animals used on this AUP wil be housed If the facility does not appear on this list please contact acs ucguelph ca Animal Housing Facility Room Number Lobby This field is optional if you can or would Eke to provide the specific room in the approved facility
45. s any role 38 How do I Renew my AUP 39 How do Amend my AUP 40 Use of Internet Explorer as a Browser to View the System 40 Animal Utilization Protocol Page 3 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION User Manual University of Guelph Animal Utilization Protocol system is a Web platform that allows authorized users to submit Animal Utilization Protocols AUPs amend renew and view AUPs electronically review AUPs and access this information from local and remote locations Roles The system offers different roles for every user The roles are described below The Principal Investigator User in charge of the AUP who is responsible for filling In the application User who is designated by the PI to complete or amend an AUP Participant Users who participate in the AUP such as technical staff or a veterinarian this user can see an AUP submitted by a PI AUP Coordinator User who has the ability to assign reviewers and moves an AUP through the approval process ACC Reviewer User who performs a review of the submitted AUP and provides comments to the AUP Coordinator Main Functionalities As we mentioned previously the system is managed in different levels depending on the role of the user This document will describe the main functionalities of the system for Principal Investigators Assignees and Participants Functionalities for the AUP Coordinator and ACC Reviewers are described in another do
46. s per observation criteria In terms of species specific behavioural changes and physiological signs list the criteria that will be used to trigger the decision to remove an animal from the teaching exercise or experiment or to terminate the teaching exercise or experiment When a health issue or injury unrelated to the experiment occurs is regular veterinary care appropriate for the animals Yes v This question relates to the care of the animals in the event a health issue or injury arises that is not in relation to the experimental or teaching work If this occurs can a veterinarian treat the animal as a regular patient yes or are there considerations that would impact the experiment or teaching activities No e g giving anti infImmatory drugs or applying skin adhesives Section 8 Procedures After you click next you will be linked to Procedures section of the AUP Procedures will be added in 3 steps Animal Information Procedures and Drugs Drugs are only to be entered if applicable Step 1 Animal Information add in the species and number of animals to be used Section 8 Procedures Step 1 Animal Information tep 2 Procedures Step 3 Analgesic and Anesthetic Drugs Species Strain Please separate strains with semi colons Include international nomenclature for strains for Genetically Modified Animals Quantity Remove Add another item On this screen fill out the species strain and q
47. that you re looking for please search using the central directo The users central login id is the portion of the email address before the Duogueiph ca Assignee Optionally please select an assignee to help you to complete AUP form The assignee will have the capability to manage this AUP on your behalf Please enter the user s central login ID If you don t know the central login ID of the user that you re looking for please search using the central directo The users central login id is the portion of the email address before the Ducguelph ca Project Name Enter 2 title that is descriptive for your project and include the species Project Category None v Animal Utilization Protocol Page 11 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Please note that for using the Central Directory this can be used to identify a person s user ID However until they have logged into the AUP electronic system using their central log in ID or create an external ID they cannot be added to an AUP If a form is completed by an assignee it must be approved by the PI before it can be submitted to the Department Chair for signature and submission to the ACC for review To complete the AUP form completely continue filling out all questions in the form Section 2 Lay Summary Section 2 Lay Summary Research problem s or instructional principle s this project addresses Background and Obje
48. ther Procedure to determine if your procedure fits within one of the standardized list items For example administering a drug or experimental substance should always be entered under Administration of Substance with the details of the substance and route provided in the details box Step 1 Animal Information Step 2 Procedures Step 3 Analgesic and Anesthetic Drugs Name of Procedure i a Please search the list and select a listed procedure where ever possible Select gem If you specified other please provide further details ql procedures and provide details in the extra information box below Select other ONLY if the general procedure is not listed Associated Distress or Pain Level Please enter the user s central login ID If you don t know the central login ID of the user that you re looking for please search using the central directory service The users central login id is the portion of the email address before the Ducguelph ca Remove Add another item Extra information Please provide additional information about the above selected procedure Remove Add another item Please ensure you enter the User ID of each individual who will perform the procedure Each User ID listed here MUST be reflected in Section 5 Personnel or listed as the PI Step 1 Animal Information Step 2 Procedures Step 3 Analgesic and Anesthetic Drugs Name of Procedu
49. this message Animal Utilization Protocol search Web Directory Library Become a PI My AUPs My account You have successfully submitted your request You have to wait for ACC approval PI Request F twahabi has been created Welcome Please take a moment to fill out your user profile View Edit Devel Talel Wahabi Last Name Wahabi First Name Talel Common Name Talel Wahabi History Member for 7 sec 2011 University of Guelph And you will receive an e mail notification to confirm that you submited your request Step2 After the AUP Coordinator approves your request you will receive an e mail notification and you will have access to the link to create AUPs 3 How Create an AUP Roles Participant Authenticated user and the Principal Investigator PI Before you create your AUP ensure that all the participants and people involved in this AUP are registered in the system and they have updated their profiles Animal Utilization Protocol Page 9 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Assignee a person to help you to complete AUP form The assignee will have the capability to manage this AUP on the Pls behalf How To Add Non Registered Personnel in the System In the event a person involved or to be listed on an AUP is not registered in the system this can be handled in one of the following ways 1 If the individual is associated with the University a
50. ty Add another item Step 2 Add the procedures for the species listed in Step 1 Step 1 Animal Informatid Step 2 Procedures Syep 3 Analgesic and Anesthetic Drugs Name of Procedure None Yv Please search the list and select a listed procedure where ever possible Select general procedures and provide details in the extra information box below Select other ONLY if the general procedure is not listed If you specified other please provide further details Associated Distress or Pain Level None v Name Please enter the user s central login ID If you don t know the central login ID of the user that you re looking for please search using the central directo The users central login id is the portion of the email address before the Duogueiph ca Add another item Extra information Please provide additional information about the above selected procedure Remove Add another item The procedures list has been standardized with a details bar for specifics below the procedure In the details box please either indicate the other procedure not on the list or provide details to general procedures for example the substance to be injected or the type of surgery to be performed Animal Utilization Protocol Page 22 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Please consider the list of procedures before selecting O
51. ty of Guelph Account details for Talel Wahabi at Animal Utilization Protocol inbox x wsadmin uoguelph ca 6 50 AM 0 minutes ago A hi to me Talel Wahabi Thank you for registering at Animal Utilization Protocol You may now log in by clicking this link or copying and pasting it to your browser knObNKB dahRRD2TEAPAY ysCPCg This link can only be used once to log in and will lead you to a page where you can set your password Foe setting yet password you will be able to log in at loh_ca research acs apps aup user in the future using username Talel Wahabi password Your password Animal Utilization Protocol team Animal Utilization Protocol Page 5 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Please be prepared to update your password as this link can only be used once to log in and will lead you to a page where you can set your password Please note that only non University of Guelph accounts can update and change their password Please be sure to update your profile and add all your qualifications Animal Utilization Protocol search Web Directory Library Home Become a PI My AUPs My account Log out You have just used your one time login link It is no longer necessary to use this link to log in Please change your password View Edit Devel Talel Wahabi Last Name First Name Common Name a Talel Wahabi Department Phone Qualifications Please provide
52. uantity of animals involved This could be all or a portion of the number of the species requested in Section 6 Animal Details All procedures to be performed on this group of animals will be entered in Step 2 Procedures If there are different numbers of animals for different procedures you can either Animal Utilization Protocol Page 21 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION a Click Add another item and add the same species with the different number and then enter the procedures or b Enter the maximum number of animals to be used for the procedures For example if 100 mice will have blood collection and 60 mice will be tattooed enter the number 100 and then list all procedures Then the actual numbers of animals to be used in each procedure should be delineated in the sequential description of animal use box below If you click add another item on this screen another line for a different species will be added with all 3 steps for animals procedures and drugs available Note fill out all 3 steps if analgesic anesthetics drugs apply for the first species before proceeding to the next species or group of animals Section 8 Procedures Step 1 Animal Information Step 2 Procedures Step 3 Analgesic and Anesthetic Drugs Species pf tO Strain Please separate strains with semi colons Include international nomenclature for strains for Genetically Modified Animals Quanti
53. who wish to give the responsibility and access to another individual be it a graduate student technician or other member of the project to fill in and amend the AUP Assignees can only fill in AUP information The responsibility of signing and submitting the AUP and therefore taking responsibility for the AUP will always fall to the PI An AUP will not be submitted for review until the PI signs and submits the AUP in the system after the Assignee has filled it out Section 1 Background Minimal information required by a PI to begin an AUP and turn it over to an Assignee Pl user ID Assignee user ID Project Title Purpose of Use Classification Pilot Study question Once this information is filled in and the PI clicks save the assignee will receive the following email message Hello A principal investigator has identified you as an assignee on their AUP This means that they have given you the capability to manage the AUP on their behalf To access the AUP please follow the following link http dev web uoguelph ca research acs apps aup user login destination node 1199 UNE Animal Utilization Protocol My AUPs Section 1 Background Section 5 Personnel Section 6 Animals Section 8 Procedures Section 9 Appendices Review Status Initial x Section 1 Background Principal Investigator or Instructor Please enter the user s central login ID If you don t know the central login ID of the user
54. y Animal Source s Supplier s Step 3 Complete Disposition Information Indicate the source or supplier None v Details Name of Facility of Colony Herd Flock Other AUP Number Location of Field Study or Client animals to be used r Address Donor or Owner of Private Facility Name Company or Private Farm Facility Name Street Province State Country Phone Number Postal Code None None v Be careful not to hit the Add another item at the very bottom of the box as this will add an entire new species Step 3 is the Disposition of the animals Step 1 Complete Animal Details Step 2 Specify Animal Source s Supplier s Step 3 Complete Disposition Information Type Quantity Details f None Add another item Remove Add another item Animal Utilization Protocol Page 19 of 40 November 10 2011 CCS WEB SOLUTION FUNCTIONAL SPECIFICATION Please fill in all relevant fields for each quantity For multiple dispositions of animals click Add another item to add another disposition Step 1 Complete Animal Details Step 2 Specify Animal Source s Supplier s Step 3 Complete Disposition Information Type Quantity Details 4 None v Add another item Add another item Be careful not to click the Remove button at the bottom of the p

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