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CaseCenter 2.4 User's Guide

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1. iz ek 3DHISTECH CaseCenter 2 4 User s Guide November 11 2013 CC24 UG EN Rev1 Rev 1 CaseCenter 2 4 User s Guide Contents DISC VANINON sacs envacvan vases cecsanaes ecruundnsesseasnssnetessematwset aticatncsevscotuiessannsoeiuetenssevasshossseusecseneeweeseacteesesuser este 4 Character Types and SymbolS sessssesesesessssesececesescscsoececesesosoececssssssoecesesesssoecesesesoesesesssseseeosecsese 6 Terma and ADDE VIATON o a E E E E E E 7 TADOU CaS CCG GL seco savorscsansassesecssavesscevcausesenocsarsasssenoensteads vans cxnuesuescosssnuswosnsteetsueseateacececarerense 8 1 1 Storing and Managing Digital Slides through CaseCenter cscccccssecccessceeeeseeeseeeeeeeeeeaees 10 TREE SK ES SEE ne en ee ne ee ee eee ee eee 11 1 3 Uploading a Slide to a CaSCCONnte r ecccccssscccccssseccccesececceusececseusececseaseeesseaeecesseaesessseeessaeess 11 Z COMNECEINE To Case C CNC oairsec sescsesnesiensasncaterenscencorconsssenasrsnnieswineeeatacoaanateaiseeussnerssonsmeesnsacenestests 13 2 1 Connecting through Pannoramic ViCWEL cccssccccssscccessececeececeesceceeneceseuecessueeeseaecesseeeeeees 13 2 2 Logging in to CaseCenter through CaS ViICWED ccssecccssecccesseeccsececeececeesceeeeneeeeeeecesseesesees 13 2 3 Logging in to CaseCenter through the Web Interface cccccssccccssececessceceseceeseceeeeenceeeeeeees 13 3 CaseCenter Main Application Screen cccsscsccccsccscsccccsccccsccccscscce
2. T His Lost and Found Slides Gy Research C Routine Pathology View type Order by i aji 3 m i Default Slidename E Examined v New v v 995 12_CD10 995 12 CD20 995 12 HE I 2 995 12 Ki 67 1 995 12 CD10 995 12 CD20 995 12 HE 2 995 12_Ki 67_1 lymphatic organs lymphatic organs lymphatic organs lymphatic organs IHC_CD10 IHC_CD20 HE IHC_KI 67 2008 05 23 08 42 57 2008 05 23 08 50 12 2008 05 23 09 21 00 2008 05 23 09 26 18 3 1 User Panel At the top right corner of the main application screen there is a panel to display the name and type of the user currently logged in User type is presented by the color of the avatar green if the user is a Moderator blue if Normal and red if the user is Restricted The time left before you are logged out due to inactivity is displayed here Mr Doe John 00 29 minutes left Change profile November 11 2013 Rev 1 3DHISTECH Ltd 16 49 CaseCenter 2 4 User s Guide 3 CaseCenter Main Application Screen For users who cannot modify their profile data for example LDAP users View profile is displayed instead of Change profile Upon clicking View profile the User data window is displayed User tithe Family name MT Smith Given name Bill E mail billsmith domain com Other Contact 55 555 555 Specialties If you click on the Change profile button the Edit user window opens in which the following options are available for you to
3. 2 Logging in to CaseCenter through CaseViewer After launching CaseViewer select the CaseCenter panel from the startup page then enter user credentials to access the designated server For more information on CaseViewer read CaseViewer Help Guide 2 3 Logging in to CaseCenter through the Web Interface 1 Type the URL of the CaseCenter the local System Administrator can assist you with the proper address in your web browser to access the CaseCenter AN Important The supported browser is Google Chrome November 11 2013 Rev 1 3DHISTECH Ltd 13 49 CaseCenter 2 4 User s Guide 2 Connecting to CaseCenter 2 Enter your User name and Password and click login to access the page If a global cookie is set to ON by the administrator the login box may contain a checkbox to make the computer remember the user s login Upon selecting this option it is not necessary for the user to log in to the server again through the same browser before the cookie expires CaseCenter 24 Login SDHISTECH F Remember my login on this computer SDHISTECH Ltd Login AN Important Open CaseCenter interface in one tab only with your browser because connection issues may arise when working on the same server in several tabs If there are no free slots left to access the server you receive a message displayed in the login window informing you that you are placed in the login queue CaseCenter 24 Login SDHISTECH server is fu
4. 995 12 Block 995 12 Not Available Cancel Accept e View type select any of the following options o Default Slide tray view o Simple o Show description o Slide tray e Order by you can select any of the following ordering methods from the drop down list o Image type o Slide name o Organ o Staining o Scan name o Status o Custom Order Since slides can be reordered by dragging in Slide tray view mode order will automatically be displayed as Custom order November 11 2013 Rev 1 3DHISTECH Ltd 32 49 CaseCenter 2 4 User s Guide 4 Slides and Folders e Checkbox Check to select every item of the Folder Case Block to open them with Pannoramic Viewer e Align Click DD to align selected slides based on a reference degree by which slides in a set can be rotated to an identical orientation Quick search View type Order b Quick search View type Order b x ie U5 E Default x Slide name l O Default x Slide r name f 21 Slides before alignment Slides after alignment 3 ae 4 ote amp S HR P gt eg Ea Ea Ea a a Cc Cc Cc AY 6366 a BSA ve DRS 6366 FE 3b5 ax lease ho ew ej 0ea18 716a60c7a1 1eaf4f3f5a18f9403 200db84adb07fbe926 96ce0558ece18b3b301 716a60c7a1 1eaf4f3f5a18f9403 b07fbe926 96ce0558ece18 n a n a n a n a n n a n a n a n a na n a n a n a n a n a n a n a n a n a n a n a n a 2012 06 20 23 43 19 2012 06 20 22 28 38 2012 06 21 06 06 00 201
5. User Name test Password a Secure connection Cancel 4 Ensure that the slide is visible in the navigation tree on the Local tab in Pannoramic Viewer If the slide is not visible add the containing folder to the navigation tree a Toopen the slide click in the toolbar b Browse for the folder that contains the slide c Click Add Folder then click Close 5 Right click the slide that you want to upload and then select Upload Slide to Teleconsultation Server 6 Set the properties for the copy of the slide to store on CaseCenter 7 Click Start Upload AN Important Accessing Virtual Tray or Virtual Slide requires a license therefore without a valid license these type of slides cannot be opened nor edited with Pannoramic Viewer but it is available for you to edit slide data in CaseCenter November 11 2013 Rev 1 3DHISTECH Ltd 12 49 CaseCenter 2 4 User s Guide 2 Connecting to CaseCenter 2 Connecting to CaseCenter 2 1 Connecting through Pannoramic Viewer 1 Launch Pannoramic Viewer on your computer 2 To start Teleconsultation click om in the toolbar 3 Enter the server address and your authorization information into the corresponding field HTTPS connection can be established by selecting the Secure connection option Click OK when finished Connect to Teleconsultation Server Address 10 1 30 131 213 User Name test Password kk Secure connection E Cancel 2
6. a Teleconsultation session click Em in the Pannoramic Viewer toolbar November 11 2013 Rev 1 3DHISTECH Ltd 42 49 CaseCenter 2 4 User s Guide 6 Slide Sharing 6 Slide Sharing Select the Share menu option from the main menu If a user has shared a slide with you it will be listed in the Shared with me window w Share v l Default x Shared by me Preview Image Type Slide name Barcode Privilege Share owner Organ Staining Scan Date Edit 2008 01 3 2D Slide 10301 07 ER I Read Write Bronson Brad Prof breast Estrogen IHC a 3 A OND Be 2D Slide 10301 07_HER2_ Read Write amp Bronson Brad Prof breast Her2 IHC crate d 4 be P o a 2D Slide 10301 07 HE 1 1 Read amp Bronson Brad Prof breast Hematoxylin eosin al Fil You can share your slides with other users and or groups in the Slides amp Folders window see section 4 2 2 Slide actions e When you share a slide on the server all the designated users will be able to see the slide if they check their Shared with me window e You can use the CaseCenter groups created by the administrator for example a group of users who specialize in a particular cancer type w Share v c SEEREN TEE Quick search View type lm Default x Shared by me E Preview Image Type Slide name Barcode Privilege Share to Organ Staining Scan Date Edit en a 2008 05 14 F 2D Slide 5499 ki67 Read Write amp Dep 1D n a n a oof distor Fal O E f s 25
7. algorithm on one slide or on a set of slides grouped into an TumorBoard project For more information on Pannoramic Viewer modules see Pannoramic Viewer 1 15 3 User s Guide 4 You can upload slides to a CaseCenter server also from the local storage with file transfer via Teleconsultation in Pannoramic Viewer Teleconsultation via Pannoramic Viewer allows you to view remote slides slides stored on a CaseCenter server With this feature of Pannoramic Viewer you can also host a Teleconsultation session or participate in a session initiated by another user 5 You can also share slides for E School For information on that product see E School 1 11 User s Guide One example of a server based teleconsultation solution is www pathonet org 6 Slides stored in CaseCenter server may be shared and can be opened with CaseViewer application CaseViewer can be downloaded by clicking at the top left corner of the CaseCenter login site For more information the application and usage see CaseViewer Help Guide November 11 2013 Rev 1 3DHISTECH Ltd 9 49 CaseCenter 2 4 User s Guide 1 About CaseCenter 1 1 Storing and Managing Digital Slides through CaseCenter CaseCenter is a platform for managing folders slides cases blocks and other documentations The figure below demonstrates how slides can be stored and managed on a server A Service Unit is an element of the system where slides are physically stored on and slide processes
8. change user preferences e You can change your title family and given name e mail address password other contacts and specialties User name and Moderator right is given by the administrator therefore the User name field is inactive in this window NOTE Use only printable ASCII characters 32 126 when creating a new password Edit user User title Family name User name pir Doe johndoe Given name Old Password John E mail Password johndoe aaa com Other Contact Open Slides in Pannoramic Viewer Specialties O Cancel Accent November 11 2013 Rev 1 3DHISTECH Ltd 17 49 CaseCenter 2 4 User s Guide 3 CaseCenter Main Application Screen e Open Slides in Choose Pannoramic Viewer or Java Viewer as the default slide viewer application in which the selected slides can be opened NOTE Moderator user is allowed to set other users access rights for folders to which he she has RW right except to folders with R or 0 rights Click on the standby button to log out from the CaseCenter interface NOTE If closing the browser tab window and your browser is set not to remember to previous session it may happen that you cannot log in again because of licensing issues the maximum number of user licenses is reached Modify browser settings as follows If using Internet Explorer open New Tab then select Reopen last session option on the bottom of the tab If using Mozilla Firefox open Tools Options men
9. gt ee i 2008 05 14 F 2D Slide 5499 ki67 Read amp ResearchR n a n a acl Fil an gi 2008 05 14 E 2D Slide 5499 ki67 Read amp Department n a n a 18 36 47 ft 3 gt 2008 05 14 gt 5400 p5 AW fi 2D Slide 5499 p53 Read Write amp Dep1D n a n a 18 08 41 Fil 2008 05 14 2 5499 p5 searc I F 2D Slide 5499 p53 Read amp Research R n a n a 18 08 41 Fil 2002 05 12 A 2D Slide 5499 p53 Read Department 1 ma n a tnaa e Click A to edit slide data e Tick the checkbox on the left of the thumbnail image of the slide then click the im button to cancel sharing them with a user November 11 2013 Rev 1 3DHISTECH Ltd 43 49 CaseCenter 2 4 User s Guide 7 Search in CaseCenter Server 7 Search in CaseCenter Server amp Search c Text Organ Status Save as All organ X Examined X Save Search Date From Date To Staining Saved searches Hematoxylin eosin x Not set Delete Reset ig i View type Slides gt S it Default X Folders Select Search from the menu options to search for slides and folders stored on the CaseCenter server In this window you can search for the following attributes e Text search for character string in slide name and in the description fields of folders cases blocks and slides e Date from to e Organ selectable from list e Staining selectable from list e Status selectable from list
10. not be able to see all the slides stored on the server and it is possible that some of the slides are not even visible to other users except they are shared For example if a parent folder is protected some of its content is hidden because you are a user with limited user privileges therefore the folder name is grayed out but it is possible for you to access the content of a sub folder if you are permitted by the administrator or a user with moderator rights Uploading a Slide to a CaseCenter You need Pannoramic Viewer to upload files to the server Q Tip Since the upload may take a significant amount of time depending on the slide size it is recommended that you upload the slide to the server before starting a Teleconsultation session You can only upload one slide at a time from Pannoramic Viewer Administrators can perform bulk uploads via file transfer 1 Launch Pannoramic Viewer on your computer E 2 To connect to the CaseCenter server click im in the toolbar November 11 2013 Rev 1 3DHISTECH Ltd 11 49 CaseCenter 2 4 User s Guide 1 About CaseCenter 3 Enter server address and your authorization information User name and password into the corresponding field HTTPS connection can be established by selecting the Secure connection option Click OK when finished NOTE If you encounter a problem contact the CaseCenter administrator Connect to Teleconsultation Server ree 10 130 131 213 x
11. take place at as well slide access and management is attained through the HUB Users who have registered on the server registration is performed by the server administrator or a moderator user can manage and use their slides on the server in the following ways upload slides to the server arrange slides in folders cases or blocks for example group slides according to their staining types or your research projects share slides with other users o with users who have an account on the same CaseCenter either having read only or read write access to the folder case block containing your slide or if you share the slide with them explicitly o with users who will access the slide via E School invite other users into Teleconsultation sessions to discuss slides participate in Teleconsultation sessions initiated by another user November 11 2013 Rev 1 3DHISTECH Ltd 10 49 CaseCenter 2 4 User s Guide 1 About CaseCenter 1 2 1 3 Accessing a Slide Whether you can open and view a slide stored on a CaseCenter server depends on the following criteria e you can always access the slides for which you have read only and upload slides with read write access rights e you can see slides that other users share with you for instructions see section 6 Administrators or users with moderator privilege can give permission to particular users or groups for accessing specific folders block cases This means that you might
12. this product have not been established November 11 2013 Rev 1 3DHISTECH Ltd 4 49 CaseCenter 2 4 User s Guide Third Party Disclaimer LibTIFF TIFF Library and Utilities 3DHISTECH Ltd is not liable for damage of whatever nature including but not limited to general or specific damage indirect damage consequential damage or incidental damage including damage resulting from lost profits interruption of business loss of business information pecuniary loss or similar damage that stems from or is associated with the incorporated part of this Product that is made by Silicon Graphics Inc THE SOFTWARE IS PROVIDED AS IS AND WITHOUT WARRANTY OF ANY KIND EXPRESSED IMPLIED OR OTHERWISE INCLUDING WITHOUT LIMITATION ANY WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE IN NO EVENT SHALL SAM LEFFLER OR SILICON GRAPHICS BE LIABLE FOR ANY SPECIAL INCIDENTAL INDIRECT OR CONSEQUENTIAL DAMAGES OF ANY KIND OR FOR ANY DAMAGES WHATSOEVER RESULTING FROM LOSS OF USE DATA OR PROFITS WHETHER OR NOT ADVISED OF THE POSSIBILITY OF DAMAGE AND ON ANY THEORY OF LIABILITY ARISING OUT OF OR IN CONNECTION WITH THE USE OR PERFORMANCE OF THIS SOFTWARE Further Information For the latest information on 3DHISTECH products and services please visit our website at http www 3dhistech com Company Address 29 33 Konkoly Thege Miklos Street Building 6 1121 Budapest HUNGARY November 11 2013 Rev 1 3DHISTECH L
13. 2 06 21 06 56 55 2012 06 20 23 43 19 2012 06 20 22 28 38 2012 06 21 06 06 00 2012 06 21 06 56 55 never never never never never never never never e Folder Case Block name e Attachment Click Fo to upload files as attachments and to display the list of attachments if there is any belonging to the actual folder NOTE Attachments can be uploaded for the current folder and not for a specific slide Omit using accented letters in file names you want to upload as these characters will change after batch download of attachments and decompressing the ZIP file Important If an attached file name starts with a character or the file extension contains a space its downloading may fail depending on the browser type To attach a file to the actual folder follow the below steps 1 Click Browse in the Attachments window to upload a file as an attachment 2 Select the file then click Open in the File Upload window 3 Click the Upload button in the Attachments window to upload the file November 11 2013 Rev 1 3DHISTECH Ltd 33 49 CaseCenter 2 4 User s Guide 4 Slides and Folders Attachments IFJ File name Upload date Download Delete Upload file amp upload Close e Use the selection checkboxes at the first column or the select all checkbox at the column header to select multiple files e Multiple files can be downloaded by clicking the Download button or click t
14. 5 PCT AT2006 000493 EP 06817470 5 US 12 095 596 HU0900741 US 61 264 732 US 11 826 752 P0401870 PCT IB2005 050344 US 11 662 976 HU0700409 US 12 042 050 US 77 636 144 and 007502032 The above mentioned granted patents granted utility model registered trademarks pending international and national patent applications and the other corresponding IP are the sole properties of the 3DHISTECH Ltd 3DHISTECH Ltd is not liable for damage of whatever nature including but not limited to general or specific damage indirect damage consequential damage or incidental damage including the results of the analysis of the digitized slides for example change of health status related to erroneous diagnosis from the digitized slide s that stems from or is associated with use of Product digitized slides quality of staining quality of stained slides quality of used method of staining 3DHISTECH Ltd assumes no responsibility for the functionality and fault free condition of your application programs Workflows VBA macros Commander scripts CAUTION For research and education uses only not for use in diagnostic procedures This product has not been approved or cleared as a medical device by the U S Food and Drug Administration nor any other regulatory authority The data and images obtained or viewed using this product are not intended for clinical or diagnostic use For performance evaluation only the performance characteristics of
15. Except for temporary LDAP users search parameters can be saved for later use by entering a text into the Save as field and clicking Save or delete after selecting the entry from the Saved searches drop down list then clicking the Delete button Search results will be displayed after clicking the Search button You may narrow the list by adding other criteria such as Date From or Date To Organ Staining or Status R Search c Text Organ Status Save as All organ v New X Save 4 Search Date From Date To Staining Saved searches ias z Not set x Delete Q Reset lm Default X Folders 77 Image Slide name Staining SU IP Preview Type a Barcode Folder Path Organ Scan Date Status Edit 2 Li z iu s Hospital A New Cases Unassigned Case lymphatic 2003 05 23 Z v 2D Slide 995 12 HE_I 1 995 12 HE 1 1 995 12 Block 995 12 organs HE cc ug 08 56 54 A ae das Hospital A New Cases Unassigned Case lymphatic 2008 05 23 New rv 2 2D S D 995 17 9965 9 E HS a teas a ro Sarl SS f a 2D Slide 995 12_HE_ 2 995 12_HE_I2 995 412 Block 995 12 organs HE ote 09 21 00 f November 11 2013 Rev 1 3DHISTECH Ltd 44 49 CaseCenter 2 4 User s Guide 8 Users amp Groups Se Users amp Groups v User Username User title xy brianscott Dr dep1 2 johndoe Mr routine student 8 Users amp Groups eg Given name Family name Users last logon time User level User typ
16. JET OUD APEE SEE REE EE REDE RE ED ERE ERR 7 9 10 11 19 22 23 24 25 29 36 39 41 43 45 H ESS ee ene nt be cence at ce neem sa cae teen hae caren naar E dares aaah A E E E 35 PMI FEE evar E E E on cis E E E EE AE ETT E EA A E EA 10 L EDAP orn TE E TEE E TEE 17 44 45 p Pannoramic VICWEL cccecececeeesecesecececececeeees 2 3 8 9 11 12 13 18 33 34 36 40 41 42 46 48 S E a seco totes ects gee essere esses owen sap onset N E 2 4 8 9 10 19 20 28 44 45 SOR VEL eseese 2 3 8 9 10 11 12 13 14 16 18 19 20 29 36 40 41 43 44 46 47 48 BIC ERE ES SEE RE cera TE os gencaacomnconateannces A 10 36 E epee eee te I E E ete 9 10 11 19 29 35 41 43 T TEICCONSUITATION cccccceceseeceeceseeensenceees 2 7 8 9 10 11 12 13 19 36 37 38 39 40 41 42 48 U NO AG cet ERE E sneteoeh vats E E A EEN EET ES EGE EEN 9 10 11 12 18 30 33 35 36 41 November 11 2013 Rev 1 3DHISTECH Ltd 49 49
17. adjuvant chemotherapy and then underwent a r eor 10301 07 HE 1 1 n a breast Hematoxylin eosin 2012 07 05 12 39 23 Available functions e Editing or handling slide data e Attachments e Open slide e Change view type e Share e Upload macro Inactive functions e Folder tree e Copy slide e Move slide e Delete slide November 11 2013 Rev 1 3DHISTECH Ltd 35 49 CaseCenter 2 4 User s Guide 5 Teleconsultation 5 Teleconsultation The Teleconsultation gives you access to digitized slides from a remote location Slides can be examined and evaluated by users who have invited by the host during a Teleconsultation session You can consult about slides with other users in real time or in asynchronous mode also with the chat support AN Important Note that the file sizes of digitized slides are large the size of the MRXS file and the associated folder is often 1GB or above Therefore it is recommended that you use an Internet connection that has at least 1000 kilobit s capacity when you are uploading slides or when you participate in a Teleconsultation 5 1 Overview of Teleconsultation You can use Teleconsultation for telepathology to evaluate digitized slides stored on a 3DHISTECH CaseCenter server via the Internet using the CaseCenter application in online mode You will need the Teleconsultation module of the Pannoramic Viewer to upload slides one by one to a 3DHISTECH CaseCenter server Uploading the slid
18. cecescnscccsceccecececececscecscecececs 16 Sed USER PREBEN E E E E 16 3 1 1 Managing a CaseCenter User ACCOUNT 2222 EDER ranne an ssar skus rE Er ara nE E rE ENIN EE 18 3 1 2 Changing a User PaSSW Ol is as LEDE ianea AN NENANA EAA ea aa Eia 18 OZ N OPU OPU ON era E E E E ATE T 19 Sides and FO CT Sissies acy scesersansdnense E A E EEA 20 AT Folder Tree Pane leirien Ennn EAE EAE EEE 20 4 1 1 Folder Color WANG 25 seciazcrsacomnesteaaesaeoetesiisacnesoneesavooanveuinorseaseraa TTEA Aiara 21 4 1 2 Folder operation DUTODS ssoissirte dissini inni NNE ENEAN Ea En TEENAAN RA aa ia aaa aa 21 4 2 Slide Attributes and Process OptiOns ccscccsssecccsscecescccceseceeeeeceseescceseeceseuecesseneesseneceseges 25 CMS IUES oE EEE E AAEE E 25 2 22 SNS COIS AP E EE N E E E A E A O A EA E E T 28 AO CASE VOW MOO Gorosti ena EE E E TEET E EE 35 S TEI COMS UNA tOM eoin E EEEE AEE E E EOE EEN 36 SA Overview OF TeleconsultatiO Nescis iien o nT EE E TE REENE AS SEENE 36 5 2 Requirements and Privileges for Hosts in a Teleconsultation S SSION ccccsecceseseeeeeeeeeeees 36 5 3 JOINING a Teleconsultation SESSION ccccccsseccceseccceesecceesececeeececsenceeeeecesenecessuscesseeeeseeeeeeeees 37 5 4 Creating a TelecOnsultation S SSION cccccssecccesececceseccceseceeaeececeesceeseeceseuecesseeeeeseecessgecetees 38 5 5 Opening a slide via Tele CONSUITATION ccccccssececesececensceceesececeuececseseeesenecceecteeeseeeteneeeseeeass 40 5 6 Work
19. e Details 5 Brian Scott amp Normal User Userimpored amp D Dep 1 2012 02 06 16 40 56 amp Normal User CaseCenteruser amp John Doe 2012 08 22 04 30 36 amp Normal User CaseCenteruser amp R Routine 2012 02 05 22 47 34 amp Moderators CaseCenteruser amp S Student amp Restricted User CaseCenteruser amp The Users amp Groups window displays information regarding the data of registered users and groups created by administrators The Users and Groups information is separately displayed on two different panels To select a user or group in order to see their data scroll down the list in this window Also you can search for users or groups to narrow the search results enter the text in the Quick search text box NOTE Imported LDAP users are displayed with blue background To access user or group data click the amp or the amp button amp User data mm Group data User title Family name Group name Doe Department 1 Given name Select User A DDep 1 E mail amp R Research asd asd com Other Contact Specialties User and group data can be edited by administrators only If you find something that is needed to be modified contact your administrator directly November 11 2013 Rev 1 3DHISTECH Ltd 45 49 CaseCenter 2 4 User s Guide 9 Troubleshooting 9 Troubleshooting 9 1 I Cannot Connect to the CaseCenter from Pannoramic Viewer Check the following to ensure that you can access the server 1 Is y
20. e creates a copy on the Service Unit keeping the original slide on your local computer 5 2 Requirements and Privileges for Hosts in a Teleconsultation Session e Ifthe Host quits the group the Teleconsultation session closes for all participants Other participants can leave the session without terminating it e The Host can modify the slide by adding annotations at any time Other participants may request permission to modify the slide from the Host e Only the Host can edit a Teleconsultation report Other participants can only read the report after they received it from the Host November 11 2013 Rev 1 3DHISTECH Ltd 36 49 CaseCenter 2 4 User s Guide 5 Teleconsultation 5 3 Joining a Teleconsultation Session In the TC Invitations window there is a list of Teleconsultation sessions you have been invited to Select the one you want to participate in by clicking on the list item gt Teleconsultation TC invitations Quick search TC requests Host of Teleconsultation Start date Expiration date Teleconsultation_O Bronson Brad Prot 2012 04 28 10 00 2012 05 01 10 00 The pop up window displays all the necessary information regarding the session such as start date and expiration date of teleconsultation description subject slides or projects and attendees Teleconsultation details Teleconsultation_02 Start date 2072 04 28 10 00 Expiration date 2012 05 01 10 00 Description Subject slides Attendee
21. er e Incase the amp character is present in the string of the file name it will be opened in Pannoramic Viewer but its name will be displayed shorter will end with the character immediately preceding it Solution to all the above mentioned issues that you rename the slide and reopen it 9 6 Slide name is too long The maximum length of slide name is a string of 70 characters in CaseCenter but if scanning options are set in the Scanner software application that the digital slide receives its barcode string as its file name the name string can be as long as 256 characters In CaseCenter during editing any of the attributes organ staining etc of a slide which name contains more than 70 characters make sure to cut or rename the slide and type less than 70 characters in the file name field November 11 2013 Rev 1 3DHISTECH Ltd 48 49 CaseCenter 2 4 User s Guide Index Index B OCH ee cc sc ete cetera A E mesa peat oats cota 10 11 20 21 23 24 25 26 28 33 C OAS c E E E E EEE TA 10 20 21 23 24 25 26 28 33 47 48 CaSeCCeNter ccceccesseceeeeeeees 2 3 7 8 9 10 11 12 13 14 16 18 20 36 40 41 43 44 46 47 48 OS OU area seats ari eaten nite rn bases E E A pacts xe OEE P E canteen tab snus ced AA A ERE FE 2 35 E e eee ne TE een ee nn nena Toe en eee 12 17 18 23 26 27 31 34 36 43 F FUO CS ENESTE E A vansecuerasnedastantvenodacneesamssnaaceveaceuseaees 8 G
22. es and Folders bulk KH TERE ee ee Mm Su I 7 lymphatic 2008 05 23 e ag 2D Slide 995 12 HE 2 995 12 HE 2 Srgans HE HERR New A I i l lymphatic 2008 05 23 s ole 2D Slide 995 12_Ki 67_1 995 12_Ki 67_1 ang PCK STA See New Z 2D Virtual ed ae 2013 10 17 Not Available feline BARR ALS ah poh 10 17 40 A If you edit the data of the virtual slide or tray the following windows are displayed B Edit Virtual Slide x NOT AVAILABLE Not Available E Cancel Slide name 995 12 CD10 Description Staining IHC CDG Organ lymphatic organs Automatic Slide deletion time Never expire Status New a Barcode 95 12 CD10 VS Content Preview Slide name Slide path Hospital AlNew Cases Unassigned Case 39512 CD10 095 4 2 Block 995 12 Accept At the bottom areas of these windows sections such as VS Content and VT Content display the preview image and related data of the included slide or slides NOTE Staining and Expiration date cannot be modified for Virtual Slides November 11 2013 Rev 1 3DHISTECH Ltd 31 49 CaseCenter 2 4 User s Guide 4 Slides and Folders Slide name Block 995 17 Description Status Automatic Slide deletion time New a Never expire VT Content Preview Slide name Slide path Hospital AlNew Cases Unassigned Case 5 995 12_CD10 996 19 Blocktt 995 12 Hospital A New Cases Unassigned CaseF ia 4 995 12_CD20
23. etium leo vitae adipiscing Aliquam nec nibh vitae tellus sollicitudin iaculis Mauris elementum tristique porta Fusce sodales aliquam lectus nec auctor DE 2008 04 23 A Toluidin Blue 17 08 24 A 2DSlide 198 08_G 198 08 G I colon n E Block 198 08 III 0 Micro description of Block Ill Lorem ipsum dolor sit amet consectetur adipiscing elit Cras purus eros hendrerit a tincidunt vel ullamcorper nec neque Donec egestas auctor nulla tincidunt porta felis scelerisque id Nam tellus enim placerat ut accumsan id sodales sed leo Pellentesque vestibulum pretium leo vitae adipiscing Aliquam nec nibh vitae tellus sollicitudin iaculis Mauris elementum tristique porta Fusce sodales aliquam lectus nec auctor olidin Blue 740542 New A 2DSlide 198 08_G 198 08 G I colon m The order of attributes belonging to a specific view type may vary according to the settings made by administrators The selected View type will be saved automatically and loaded next time you log in November 11 2013 Rev 1 3DHISTECH Ltd 25 49 CaseCenter 2 4 User s Guide 4 Slides and Folders Attributes Checkbox Preview Thumbnail view of the slide or image Slide type 2D Slide 3D Slide MacroSlide TMA Project or TumorBoard Project Slide name Barcode Description Organ name of the organ where the tissue specimen was originally sectioned from Staining name of the applied stain Scan date time of slide di
24. ew at the right side of the Select Slides panel Create new Teleconsultation General Information Select slides Slides can be accessed in a folder with read write permission only Gy Hospital A O Slides E New Cases Unassigned Add a 2D Slide 10301 07 PR I E 10301 07 4 Users and Groups i dii lt 6 gt i 2 i Education Slide added 2D Slide 10301 07 HE 1 1 ie Frozen Section e Research Routine Pathology Slide added 2D Slide 10301 07 ER I TB TMA e Ke aa 2D Slide 10301 07 HER2 I 4 II ED Selected slides Remove 2D Slide 10301 07 HE 1 1 Remove 2D Slide 10301 07 ER I Cancel Accept e Finally select the participants in the Users and Groups window and click Accept R Create new Teleconsultation General Information Add User A Prof Brad Bronson amp Prof Anton Aronson Sides amp DDep1 amp Prof Charlie Chang amp DDep2 amp F Frozen amp R Research amp R Routine amp S Student Users and Groups Add Group amp Department 2 amp Department 1 Moderator amp Normal amp Restricted Cancel Accept If the system is properly configured a message will be sent to a participant s e mail address whenever a Teleconsultation session is created or there is any modification regarding the session November 11 2013 Rev 1 3DHISTECH Ltd 39 49 CaseCenter 2 4 User s Guide 5 Teleconsultatio
25. f the Case and of the Blocks are displayed as well Quick search i F y j amp Hospital A View type j UO se RE Show description v amp New Cases Unassigned Preview AES Image Type Slide name Barcode Organ Staining Scan Date Status Edit E 9 ee ee E Block 198 08 I 0 GF Block 198 08_II lt 1 gt Block 198 08_III lt 1 gt Case 995 12 lt 1 gt GS Block 995 12_I lt 4 gt Unidentified cases and slides Education Frozen Section His Lost and Found Slides Research C Routine Pathology BB Sl Sm gt Micro description of Block Lorem ipsum dolor sit amet consectetur adipiscing elit Cras purus eros hendrerit a tincidunt vel ullamcorper nec neque Donec egestas auctor nulla tincidunt porta felis scelerisque id Nam tellus enim placerat ut accumsan id sodales sed leo Pellentesque vestibulum pretium leo vitae adipiscing Aliquam nec nibh vitae tellus sollicitudin iaculis Mauris elementum tristique porta Fusce sodales aliquam lectus nec auctor 2008 04 23 Toluidin Blue 17 51 18 Al 2D Slide 198 08 G I 198 08_G_I colon y E7 Block 198 08_II G 0 Micro description of Block Il Lorem ipsum dolor sit amet consectetur adipiscing elit Cras purus eros hendrerit a tincidunt vel ullamcorper nec neque Donec egestas auctor nulla tincidunt porta felis scelerisque id Nam tellus enim placerat ut accumsan id sodales sed leo Pellentesque vestibulum pr
26. gans lymphatic organs lymphatic organs lymphatic organs IHC_CD10 IHC_CD20 HE IHC_KI 67 2008 05 23 08 42 57 2008 05 23 08 50 12 2008 05 23 09 21 00 2008 05 23 09 26 18 It consists of the following interface elements e Folder Tree Panel 1 including a tree view of the server content and structure and folder operation buttons e An informational region related to the actual folder case block its name and description together with the included slides and their attributes on the Folder Content Panel 2 e Action Field 3 with several additional options for searching through ordering and filtering the content 4 1 Folder Tree Panel The tree structure of the server can be seen on this panel where the actual folder is presented by blue background The number of the containing slide is written after the folder name in brackets Hierarchically the Case is a sub level element within a folder and the Block is a sub level element of a Case You can create several cases within a folder and several blocks in a case Folder may contain slides and cases case can contain slides and blocks but only slides can be stored within a block The number of elements within a folder is specified in a bracket at the end of the folder name November 11 2013 Rev 1 3DHISTECH Ltd 20 49 CaseCenter 2 4 User s Guide 4 Slides and Folders 4 1 1 Folder Color Markings User access rights are presented in different colors of folders in the tree pane
27. gitization Status indicates the stage the slide is in Status attribute can be selected from the drop down menu and by default it is set to New either newly imported scanned or uploaded Once a slide is opened its status will be automatically switched to Examined Statuses Diagnosed and Reopened both can be set manually Edit the icon is displayed only if you have write access to the specific slide In the Edit Slide window the following slide attributes can be modified by default e Slide name NOTE Slide name cannot be longer than 70 characters and make sure it does not include the amp character For more information see sections 9 5 and 9 6 e Description o Click the Description field to enter modify information regarding the specific Folder Case or Block e Staining o Types can be set by Administrator select one from the drop down menu e Organ o Types can be set by Administrator select one from the drop down menu e Status o New o Examined o Diagnosed o Reopened November 11 2013 Rev 1 3DHISTECH Ltd 26 49 CaseCenter 2 4 User s Guide 4 Slides and Folders e Barcode e Automatic Slide deletion time e Select Never expire or specify a date NOTE Slide can be opened from the Edit Slide window by clicking on its thumbnail image Edit Slide x Slide name 95 12 CD10 Description Organ Staining lymphatic organs a IHC CD10 Status Automatic Slide deletion time New Never expi
28. he E3 icon to download a single attachment e To delete attachment s click the button to batch deletion or the icon to delete a single file e Click Yes to delete selected file s from the list Warning Are you sure you want to delete the selected Attachment s Yes No To open a slide either in Pannoramic Viewer or in Java Viewer click on the thumbnail image of the slide To edit slide attributes click the corresponding Z icon at the right side of the panel November 11 2013 Rev 1 3DHISTECH Ltd 34 49 CaseCenter 2 4 User s Guide 4 Slides and Folders 4 3 CaseView mode CaseView mode is available through HIS Hospital Information System A link is generated for a specific case in HIS and upon opening this link with a user account in CaseView mode a restricted user interface of the slidemanager view is displayed Quick search View type Order by all oe Default v Slidename 2 case002 G 0 CLINICAL HISTORY The patient was a 60 year old woman who had inflammatory ductal carcinoma of the left breast diagnosed on a core biopsy in January 2005 An axillary lymph node was positive for metastatic disease on a concurrent FNA The tumor was found to be ER positive PR negative and Her2 Neu weakly positive Workup for further metastatic disease found multiple lesions in the liver and spine as well as a5 cm mass in the upper pole of the left kidney She received neo
29. he must be cleared on the client s side Follow the below procedure to clear browsing data in Google Chrome 1 Press Ctrl Shift Del OR e Click the Chrome menu _ on the browser toolbar then Tools e Select Clear browsing data 2 From the drop down menu at the top of the dialog window select the time how far back in time you want to go It is advised to select the beginning of time as time range Make sure that the following boxes are checked e Delete cookies and other site and plug in data e Empty the cache Clear browsing data Obliterate the following items from the beginning of time Clear browsing history Clear download history Delete cookies and other site and plug in data vf Empty the cache Clear saved passwords Clear saved Autofill form data Clear data from hosted apps Deauthorize content licenses Learn more Clear browsing data Cancel 3 When you finished checking boxes click Clear browsing data November 11 2013 Rev 1 3DHISTECH Ltd 47 49 CaseCenter 2 4 User s Guide 9 Troubleshooting 9 5 Slide cannot be opened in Viewer Some minor known issues may arise when using IE8 or IE9 as the browser for using CaseCenter e Ifyou wan to open a slide starting with amp Pannoramic Viewer sends an error message Unknown system error occurred e If the slide name ends with a amp character you will get a Connect to Teleconsultation Server message from Pannoramic View
30. ication is installed the slides can be uploaded through the scanner software directly to the CaseCenter server where slides can be evaluated shared and you can also create Teleconsultation session to discuss specific cases with pathologists 3 Slides can be opened from the local computer or the CaseCenter via Pannoramic Viewer you can inspect the local slides and you can create annotations on them to mark interesting areas November 11 2013 Rev 1 3DHISTECH Ltd 8 49 CaseCenter 2 4 User s Guide 1 About CaseCenter Pannoramic Viewer is a platform for the following applications called modules e With the Teleconsultation module you can upload slides to a dedicated server and share them with other Pannoramic Viewer users to request their analysis e With the TMA module you can view and analyze slide sets in which each slide is a cut from a tissue microarray Combined with the TumorBoard module the TMA module provides you with a powerful tool to perform research scale analyses on digital slides e With the TumorBoard module you can perform an immunohistochemical analysis on a Slide set If you purchase the TMA module as well you can run your TumorBoard analysis on a tissue microarray and score the TMA project in TumorBoard e With HistoQuant MembraneQuant NuclearQuant CytoFlSHQuant and DensitoQuant modules you can define algorithms to measure various parameters on a slide Combined with TumorBoard you can run the Quant
31. ide 10301 07_ER_ Duplicating Important Duplication physically creates a copy of the selected slide s in the destination folder November 11 2013 Rev 1 3DHISTECH Ltd 28 49 CaseCenter 2 4 User s Guide 4 Slides and Folders e Move E Moves the selected slides to the desired folder in the folder tree A window similar to the Duplicate slide window appears select the destination folder to which the selected slide s will be moved from the original folder e Delete ie Removes the selected slides and the related data from the server Are you sure you want to delete these Slides Yes No e Share ei Click this button to share the selected slide s or project s with users or groups Sharing a slide generates a link pointing to the original slide When a slide is shared with a user or groups it will show up in their Share menu and its status will be automatically set to New B Share Slide Add User s 4 Prof Anton Aronson A Prof Brad Bronson dm Prof Charlie Chang A DDep 1 A DDep2 d F Frozen 4 R Research amp R Routine Read amp Write amp S Student Read only Add Group s amp Normal Moderator Department 1 Restricted amp Department 2 Read amp Write Read only 3 Cancel Accept November 11 2013 Rev 1 3DHISTECH Ltd 29 49 CaseCenter 2 4 User s Guide 4 Slides and Folders e Upload macro al IE Clic
32. ing Simultaneously on a Slide in an Online Teleconsultation SeSSION cccceeeceeeeeees 41 SS SUNN eorn e E E EE E A E T AA 43 7 Searchin Case FEER SONU CN aeiiae a S E AIETE EA EE DERES 44 November 11 2013 Rev 1 3DHISTECH Ltd 2 49 CaseCenter 2 4 User s Guide BUS ES Oe GRO UD aE EE E 45 STEOUbIES KOORDINERER 46 9 1 Cannot Connect to the CaseCenter from Pannoramic ViCWETL cccccsssseeeceeeceeseceeeeeeeeess 46 9 2 Cannot Open the Slide from the Link Someone Sent Me cccccesecceseceeesseeeneeseneceeeeeeeees 46 9 3 Cannot Change My CaseCenter PaSSWOrd cccsscccsssecccssececessceceeseceeeseceseuscesseseeeeeeeeeeeeeeees 46 9 4 CaseCenter Server upgraded by the AAMinistrator cccccseeccssecccseceeeeeeeeneeseeceeeeceeeeeeeees 47 95 Slide Cannot pe OPERAERNE SEE sager ceettco svar EE EEN 48 DG SINGS Wie 15 OO ORE iore erona EE E E E EEE 48 AOR A E E 49 November 11 2013 Rev 1 3DHISTECH Ltd 3 49 CaseCenter 2 4 User s Guide Disclaimer Copyright 2001 2013 3DHISTECH Ltd All Rights Reserved Intellectual property related to the 3DHISTECH products are as follows EP 1 789 831 US 7 663 078 EP 2 024 772 JP 2009 512685 US 12 301 781 EP 1 644 767 JP 2007 516451 US7 327 515 EP 1 994 398 JP 2008 557835 US 12 281 566 U0700210 US 6 246 785 HU0900142 HU0700404 PCT HU2007 000065 EP 08762668 5 US 12 663 537 PCT AT2006 000492 JP 2008 542552 EP 06817469 US 12 095 54
33. k this button to upload macro images Only JPEG or JPG images can be uploaded file size is maximum 1MB Uploading a macro Upload file C Users Public Pictures Slide name i 10307 07_ER_ Organ X um per pixel not set 250 Automatic Slide deletion time Y um per pixel Never expire 950 Close Upload Create Virtual Slide or Virtual Tray With this feature a virtual slide or virtual tray can be created based on the original slide or Slides If you select one slide only then you click this button and the box in which the following message appears you can select the type of virtual item to be created Create Virtual Slide or Virtual Tray Create tray Create slide In the folder content panel virtual slide is marked with a gt label and virtual tray is with a label next to the preview image of the virtual item NOT e AVAILABLE Mm ie c Not Available Examined 995 12 HE I 2 995 12 CD20 995 12 HE 1 2 lymphatic organs lymphatic organs IHC CD20 HE 2008 05 23 08 50 12 2008 05 23 09 21 00 995 12 Ki 6Y7 1 995 12 Ki 67 1 lymphatic organs IHC_KI 67 2008 05 23 09 26 18 995 12 CD10 995 12 CD10 lymphatic organs IHC CD10 2008 05 23 08 42 57 995 12 CD10 995 12 CD20 995 12 CD10 lymphatic organs IHC CD10 2013 10 16 10 06 22 November 11 2013 Rev 1 3DHISTECH Ltd 30 49 CaseCenter 2 4 User s Guide 4 Slid
34. l Hospital A C New Cases Unassigned EJ Unidentified cases and slides Education E Frozen Section HIS E Lost and Found Slides E Research Ey 2012 Department 1 Sy Prof A By 2012 Prof B Project x E Department 2 E Routine Pathology l sol hak kul bot A Folder color marking and the tasks according to the different access rights are listed below e Black Folder Read and Write access e Blue Folder Read only access e Gray No access permission but a sub folder can be visible if you have read only or read write access rights for that specific sub folder case or block Folders cases or blocks are hidden for which you have no permissions at all For example if a folder name appears in black characters when it contains slides to which you have read and write access blue if the slides are read only and gray if the slides in the folder are hidden because the slides in it are not accessible 4 1 2 Folder operation buttons This section describes the buttons above the folder tree panel Folder operation buttons may be inactive depending on folder related permissions November 11 2013 Rev 1 3DHISTECH Ltd 21 49 CaseCenter 2 4 User s Guide 4 Slides and Folders New folder fm Create new Folder Folder name Education Description Add User s Subfolders inherit the permissions of the parent folder A D Dep 1 amp DDep2 amp R Research amp F Froze
35. ll You are in the login queue Please wait Login queue position 1 of 4 Cancel You get in the Login queue based on your user level which means that the higher the level is the sooner you are allowed to log in the higher ranked user is put forward but behind the users of the same level November 11 2013 Rev 1 3DHISTECH Ltd 14 49 CaseCenter 2 4 User s Guide 2 Connecting to CaseCenter Queue number position in the queue is displayed and automatically updated You may leave the queue by clicking Cancel and every other user behind will be placed forward CaseCenter 24 Login SDHISTECH You can log in now 01 49 minutes left Password F Remember my login on this computer Cancel Login If you are at the first position in the queue and a license is set free then you will be notified that you can access the system If you do not wish to log in you will be removed from the queue after a specified amount of time has passed since the notification is displayed and the possibility of logging in is given to the user next on hold CaseCenter 24 Login sDHISTECH Queue time has expired Please log in again November 11 2013 Rev 1 3DHISTECH Ltd 15 49 CaseCenter 2 4 User s Guide 3 CaseCenter Main Application Screen 3 CaseCenter Main Application Screen The main application screen can be divided into the following elements e Header Bar 1 that includes the CaseCenter logo version information
36. n 5 5 Opening a slide via Teleconsultation In Pannoramic Viewer 1 Start Pannoramic Viewer 2 Connect to the 3DHISTECH Teleconsultation Server a To start Teleconsultation click um in the toolbar b Enter the server address and your authorization information in the dialog 3 On the Teleconsultation server tab folders and slides that you have been granted access to are displayed 4 Double click the slide that you want to open In CaseCenter After you opened the window of the selected Teleconsultation session you have been invited to and clicked the Start Teleconsultation button see section 5 3 Joining a Teleconsultation Session the following window appears Launch Application This link needs to be opened with an application Send to Pannoramic Viewer Choose an Application Remember my choice for mview links Cancel As you can see Pannoramic Viewer is selected by default as the viewer application in which the slide will be opened If you would like to choose a different application click the Choose button and browse for it or click OK to continue with opening the slide with the default program When the Pannoramic Viewer is launched you are asked to write your name in the displaying window to connect to the Teleconsultation session You can start working on the slide after you logged in Create connect to a teleconsultation group Your nick name it must be unique in the teleconsultation gr
37. n amp Prof Anton Aronson amp R Routine amp Prof Charlie Chang amp Prof Brad Bronson PTE PRESTATE a S student W Read only Add Group s Department 1 amp Department 2 Moderator Normal amp Restricted Read amp Write Read only E Cancel Accept Define properties of a new folder that you want to add to the structure This option is available for users with Read Write access rights therefore the button is inactive if a folder cannot be created at that level Access permissions for the new folder can be added only when with Read Write access rights and in Moderator user level 1 Inthe folder tree click the desired folder in which you would like to create the sub folder and if active click this button 2 The Create new folder window opens Type in the Folder name add some information in the Description field if necessary 3 Select users and or groups you would like to give access to this folder and set their permissions Click the right arrow buttons to add them to the selection list Click the left arrow button to remove items from the lists By default users are displayed with the given permissions for the parent folder and will be marked with red if you modify their permissions November 11 2013 Rev 1 3DHISTECH Ltd 22 49 CaseCenter 2 4 User s Guide 4 Slides and Folders edit folder By default you can modify the folder description only Patient or case related i
38. n starts uploading the slide The upload however might take time because digitized slides are usually large files often 500MB 1GB or larger Uploading a 1GB slide over a 2000 kilobits sec connection requires more than 70 minutes If uploading is started during Teleconsultation the waiting period for the slide might be unmanageably long and the background upload process might also reduce the speed of Te econsultation November 11 2013 Rev 1 3DHISTECH Ltd 41 49 CaseCenter 2 4 User s Guide 5 Teleconsultation 7 It is possible to work with several slides at the same time Participants always see the same slide s and the same part of the active slide as the Host 8 The Host can work with the slide for example move around on it to check its parts as in Pannoramic Viewer without Teleconsultation 9 The Host should take into consideration that Pannoramic Viewer might be displayed with different resolutions on other participants screens The best Teleconsultation result can be achieved with screen resolutions that do not differ significantly from each other 10 Participants can take over from the Host click Request control in the slide toolbar A request is sent to the Host The Host can cede or deny control to the participant The name of the user who moderates the session is shown in red in the participant list in the message box 11 The Host and the participants can also exchange comments via the chat tool 12 To quit
39. nd supports their collaboration in inspecting and evaluating the virtual slide Teleconsultation group Group created by the Host for a Teleconsultation session independently of the user groups that exist on CaseCenter Several Teleconsultation sessions and therefore several Teleconsultation groups can be activated on a CaseCenter in parallel Telepathology Teleconsultation in the field of pathology pathologists exchange information and evaluate a slide together via Teleconsultation November 11 2013 Rev 1 3DHISTECH Ltd 7 49 CaseCenter 2 4 User s Guide 1 About CaseCenter 1 About CaseCenter CaseCenter is an application through which you can store and manage virtual slides on a designated server CaseCenter is a part of the 3DHISTECH Product Family that supports tasks in the routine and research workflow of pathologists Brightfield Scan ToServer Fluorescent CaseCenter TMA Local File System PathoNet E School 1 Digitize slides which can also be tissue microarrays or slides stained with fluorescent probes with a 3DHISTECH scanner microscope for example with Pannoramic SCAN 150 For more information on Pannoramic microscopes see product brochures or the current issues of user s guides of Pannoramic scanners 2 The Pannoramic scanner microscope creates digitized slides that can be saved on a local computer connected to the scanner or if the ScanToServer appl
40. nformation can be entered into the description field Upon clicking on the Description field in case it includes any text of the selected folder case block in the Slides amp Folders panel a window similar to the following appears fe Show case description 10301 07 Description CLINICAL HISTORY The patient was a 60 year old woman who had inflammatory ductal carcinoma of the left breast diagnosed on a core biopsy in January 2005 An axillary lymph node was positive for metastatic disease on a concurrent FMA The tumor was found to be ER positive PR positive and Her2 positive Workup for further metastatic disease found multiple lesions in the liver and spine as well as a 5 cm mass in the upper pole of the left kidney She received neoadjuvant chemotherapy and then underwent a modified radical mastectomy in October 2005 that found extensive primary tumor as well as metastases in 14 of 14 axillary lymph nodes Two months later she had a lefi nephrectomy GROSS DESCRIPTION The specimen was a 280 gram nephrectomy measuring 12 cm superior to inferior 6 0 cm anterior to posterior and 7 0 cm medial to lateral There was a 4 5 3 3 cm well circumscribed heterogeneous soft orange yellow tumor protruding out of the superior pole with cystic changes and hemorrhage There was also a 0 2 cm well defined white nodule near the renal papillae in the inferior pole MICROSCOPIC DESCRIPTION Sections of the tumor showed tubules and solid nests c
41. ontaining large clear cells with sharp cytoplasmic borders dark pleomorphic nuclei and occasionally prominent nucleoli Further examination of the tumor showed a large focus of cells arranged in solid nests that had eosinophilic cytoplasm larger nuclei open chromatin and prominent nucleoli Occasional glandular ductular structures were seen Similar appearing cells were seen in the inferior pole nodule Cancel O Accept Description field becomes locked whenever a user has initiated editing so you will not be able to modify the content Moderator users are allowed to change user permissions If you would like to have the access right of a user or user group to be changed you can contact a Moderator user A moderator is always marked with a green avatar Click Accept to confirm changes November 11 2013 Rev 1 3DHISTECH Ltd 23 49 CaseCenter 2 4 User s Guide 4 Slides and Folders Folder name Education Description Add User s Subfolders inherit the permissions of the parent folder A D Dep 1 A DDep2 amp Prof Anton Aronson 2 F Frozen amp Prof Brad Bronson fm R Research lt amp Prof Charlie Chang 4 R Routine PEN E PRERE EN g 5 Student _ Read only Add Group s Department 1 r Department 2 2 Moderator 2 Normal amp Restricted Read amp Write Read only Cancel Accept EJ Delete folder After clicking the Delete button a dialog window opens Click Delete to confi
42. oup November 11 2013 Rev 1 3DHISTECH Ltd 40 49 CaseCenter 2 4 User s Guide 5 Teleconsultation 5 6 Working Simultaneously on a Slide in an Online Teleconsultation Session 1 The Host must ensure that all participants can access the slide Note that participants cannot modify the slide or take over the control 2 In CaseCenter on the Teleconsultation panel select the session and click Start Teleconsultation 3 Enter your nick or name into field of Create connect to a teleconsultation group window 4 If connected to server select the slide you want to share with others either from the folder tree on Teleconsultation server tab in Pannoramic Viewer or in the Teleconsultation window in CaseCenter then open it 5 Click the button in the slide window in Pannoramic Viewer 6 The slide is displayed in Pannoramic Viewer for all participants W Offline telecons amp a2 rN fo Cre OC ES eT DB el mw Os i EI SS FOR ETI OY EET Meoritcaion 023 Process BR a iy Em 5000 um Share unshare slide for teleconsultation W Eai pO ERS 4 Rey et Peat i Ed wee 4 ER he PAR j Fe Se NEE i oe R Fit d ae vi it scanned area ed RER pi re pe Ree Sikes ri es 400 bd C Preview Tracking history Preview and tracking history Delete Tracking History Warning If the Host tries to enable a slide that has not been uploaded to CaseCenter Teleconsultatio
43. our Internet connection in order 2 Are you entering the correct name or address to the server If you are not sure that you are entering the correct data in the connection dialog contact your CaseCenter administrator who can give you the name and or address of the server 3 Are you entering the correct user name and password You can double check by logging in to CaseCenter via the web interface If you can log in to the Server that way your user name and password is correct 9 2 Cannot Open the Slide from the Link Someone Sent Me Check the following to ensure that you can access the server and the slide stored there 1 Is your Internet connection in order 2 Does the link point to a CaseCenter where you are a user e Check the server name in the link 3 Is the CaseCenter working e Double check by logging in to CaseCenter from Pannoramic Viewer see section 2 1 via the web interface see section 2 2 9 3 Cannot Change My CaseCenter Password You might not be able to change the password assigned to you by the administrator who enables or disables password resetting when your account is created If you have trouble with resetting your password contact your CaseCenter administrator November 11 2013 Rev 1 3DHISTECH Ltd 46 49 CaseCenter 2 4 User s Guide 9 Troubleshooting 9 4 CaseCenter Server upgraded by the Administrator In case the CaseCenter server is reinstalled by the administrator the browser cac
44. r folders e Users amp Groups Show users and groups NOTE Only those tabs are visible that are selected to be accessible for the specific user type November 11 2013 Rev 1 3DHISTECH Ltd 19 49 CaseCenter 2 4 User s Guide 4 Slides and Folders 4 Slides and Folders Upon loading the CaseCenter web interface the Slides amp Folders window is displayed by default CaseCenter 2155 3DHISTECH Ltd Mr Doe John 2 4 4 33679 29 30 00 27 minutes left Change profile Cel Slides amp Folders v aa Quick search 7 a View type Order by Default v Slide name amp Hospital A iaa Cases Unassigned i Ha Block 995 12 I 2 0 aser 198 08 lt 7 E Case 995 12 lt 1 gt Micro description of Block I Lorem ipsum dolor sit amet consectetur adipiscing elit Cras purus eros hendrerit a tincidunt vel ullamcorper nec neque Blok 995 12 I lt 5 gt Donec egestas auctor nulla tincidunt porta felis scelerisque id Nam tellus enim placerat ut accumsan id sodales sed leo Pellentesque vestibulum Fa Unidentified cases and slides pretium leo vitae adipiscing Aliquam nec nibh vitae tellus sollicitudin iaculis Mauris elementum tristique porta Fusce sodales aliquam lectus nec auctor Education Frozen Section F F 7 His Lost and Found Slides Research C Routine Pathology 995 12 CD10 995 12 CD20 995 12 HE I 2 995 12 Ki 67 1 995 12 CD10 995 12 CD20 995 12 HE I 2 995 12 Ki 67 1 lymphatic or
45. re Barcode 995 12 CD10 Slide in content Preview Slide name Slide path Hospital A New Cases Unassigned CaseF 995 12_CD10 995 19 Blocktt 995 12 x Cancel Accept November 11 2013 Rev 1 3DHISTECH Ltd 27 49 CaseCenter 2 4 User s Guide 4 Slides and Folders 4 2 2 Slide actions Quick search gt View type Order by jle le im fe VE Defaut lt Side name sual A D EF Block 995 12 I Zo The elements of the action bar are as follows from left to right if Default view is selected e Tick the checkbox to select all folder items for further operation e Quick search Enter the text or character string you are looking for in the search field Search results are listed automatically in accordance with the entered text e Duplicate jl After clicking this button the folder tree is displayed in the Duplicate Slide window Click the destination folder case or block and the slide s will be copied to that specific container by clicking the Accept button Select a destination folder 5 Hospital A gt INew Cases Unassigned E 10301 07 lt 5 gt AfA lt 6 gt C Education CI Frozen Section C Research C Routine Pathology Ca TB C TMA lt 1 gt Cancel E Accept A progress bar can be seen in the Slide name field displaying the percentage of completion Preview Image Type Slide name al 2D Sl
46. rm the removal of the folder Are you sure you want to delete this folder cancel Derete NOTE Only empty folders can be deleted therefore upon clicking the Delete button a notification message appears that the folder cannot be deleted as it contains sub element s The folder that will be deleted is highlighted on the left in the folder tree e a New Case Creates a case under the actual folder Note that a case cannot be created under an other case or block Similarly to the Create new folder window description can be added to the case as well as determining users and groups and their access rights to the case Click the Accept button to create the case November 11 2013 Rev 1 3DHISTECH Ltd 24 49 CaseCenter 2 4 User s Guide 4 Slides and Folders E New Block Creates a block under the actual case Note that you cannot create a block under an other block Description can be added to the block as well as determining users and groups and their access rights to the block Click Accept to finalize block creation 4 2 Slide Attributes and Process Options 4 2 1 Slide attributes The view of slide attributes can be modified by selecting one of the four view modes Default Simple Show description or Slide tray from the View type drop down list Default view is Slide tray The folder content panel changes according to the selected view type but if a Case contains several Blocks the root content o
47. s 2D Estrogen i j Slide 10301 07 ER I breast IHC John Doe johndoe A a 2D Hematoxylin gige 1801 07 HE 1 1 breast ein 3 Cancel Sy Start Teleconsultation To close the window without participating in the session click the Cancel button or you can start evaluating the slide or slides by clicking the Start Teleconsultation button November 11 2013 Rev 1 3DHISTECH Ltd 37 49 CaseCenter 2 4 User s Guide 5 Teleconsultation 5 4 Creating a Teleconsultation Session 1 Switch to Teleconsultation window then select the TC Requests option Ss Teleconsultation TC invitations Quick search eo Le TC requests E Title Start date Expiration date Edit TC Teleconsultation 01 2012 04 20 08 00 2012 04 24 05 00 Fil 2 Click to create a Teleconsultation session e Fill in the fields in the General Information window You can name the session assign a start date and expiration date as well as write a description about the session itself Create new Teleconsultation General Information Teleconsultation title Teleconsultation_01 Slides S S i Start date hour min Expiration date Users and Groups 2012 04 20 ae r oo x 4 days later lm Description cancel Accept November 11 2013 Rev 1 3DHISTECH Ltd 38 49 CaseCenter 2 4 User s Guide 5 Teleconsultation e Inthe Slides window click the desired folder in the folder tree then click the Add button next to the slide previ
48. td 5 49 CaseCenter 2 4 User s Guide Character Types and Symbols Example Abbreviation or term that is explained in section Terms and Abbreviations Example Words or characters that appear on the screen These include field names screen titles push buttons and menu names paths or options Keys on the keyboard For example function keys such as F11 or the Ctrl O key combination Example Cross references to other documents Warning Indicates that you need an additional module to use the feature or that there are prerequisites for the task Important ie Contains an important piece of information or a recommendation The application will work if you choose not to follow the recommendation but its performance might be less than optimal Tip Contains a suggestion about using the application in some other way or to some interesting purpose November 11 2013 Rev 1 3DHISTECH Ltd 6 49 CaseCenter 2 4 User s Guide Terms and Abbreviations Annotation A particular detail of a digitized slide Host User who uploaded the digital slide to CaseCenter and who initiates the Teleconsultation about the slide CaseCenter user group Group created by a CaseCenter administrator Participant User invited to participate in the evaluation of a slide stored on CaseCenter Teleconsultation Provides access to digitized slides for several users a
49. the name of the CaseCenter server you are connected to and the User panel e Main Menu Selector 2 is a drop down element from which you can select the desired menu option A e button is situated at the right side of this bar Click this button to immediately update the content of the display after you effect a change for example in the folder structure but normally the screen is automatically updated within four seconds e Menu Panel 3 modifies according to the selected menu option Panels may be displayed differently according to uniquely customized column settings for the specific user type 24 RTM Mr Doe Joh bd CaseCenter ZAM 29 30 3DHISTECH Ltd at Change profile Eel Slides amp Folders v ESE erm my Quick search FEE Fe o amp Hospital A W i mm 2 rn Ej New Cases Unassigned ry e 35 Block 995 12 I 0 ES aca 198 04 a Ud Bo ABA Case 995 12 lt 1 gt Micro description of Block Lorem ipsum dolor sit amet consectetur adipiscing elit Cras purus eros hendrerit a tincidunt vel ullamcorper nec neque fl ESS Donec egestas auctor nulla tincidunt porta felis scelerisque id Nam tellus enim placerat ut accumsan id sodales sed leo Pellentesque vestibulum 2 Unidentified cases and slides pretium leo vitae adipiscing Aliquam nec nibh vitae tellus sollicitudin iaculis Mauris elementum tristique porta Fusce sodales aliquam lectus nec auctor Education Frozen Section F F
50. u then select Show my windows and tabs from last time from the Startup options drop down menu on the General tab 3 1 1 Managing a CaseCenter User Account Your user account user name and password is created by the CaseCenter administrator There are no restrictions on how many slides you can upload to the CaseCenter server assuming that there is still enough storage place on the server Important You might not be able to change the password assigned to you by the administrator who enables or disables password resetting when your account is created If you have trouble with resetting your password contact your CaseCenter administrator 3 1 2 Changing a User Password If you are allowed to change your password do the following 1 Open the CaseCenter main page in your web browser 2 Enter your User name and Password and click login 3 Click Change profile in the User panel and modify the password in the Edit user window see this section above November 11 2013 Rev 1 3DHISTECH Ltd 18 49 CaseCenter 2 4 User s Guide 3 CaseCenter Main Application Screen 3 2 Menu Options Ce Slides amp Folders v gt Teleconsultation Share d Search Sg Users amp Groups Move the cursor over the menu selector to see the list of options e Slides amp Folders Browse the folder structure of the server e Teleconsultation Opens the Teleconsultation window e Share View shares e Search Search for slides o

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