Home

FACET Exposure Assessment Tool User Manual

1. The substance used will be unique to the table created Any food categories created in the table will appear as options in the next step of the wizard so not all food categories in the table need be used in an assessment Select Additive w Select Assessment Type D Use pre installed FACET data Select Additive A E Search E Number Select Food Categories Select Surveys E Numb Additive Name Has MPL value E100 Curcumin MPL available E101 Riboflavins MPL available Assessment Options Assessment Summary E102 Tartrazine MPL available E104 Quinoline yellow MPL available E110 Sunset yellow FCF MPL available E11N2 imvvrertsace Ma RADI ssrsilahle No substances selected O Use my concentration data Select Concentration Table a A My Data a Date Created 4 Date Accessed F My Additive Data ES Custom E110 Table 16 Jul 2013 15 34 16 Jul 2013 15 34 E My Flavouring Data My Migration Data E My Packaging Data DE ane mo Mba Fis lt E Figure 22 Using custom concentration data Select Concentration Data If the substance of interest is a flavouring the FACET data is divided into eight options e Council of Europe 2000 e EFFA use levels provided to EFSA e FEMA reported in Fenaroli s Handbook 2005 e Young et al 2006 e OFI JECFA 2006 use levels provided to JECFA e OFI JECFA 2007 use levels provided to JECFA e OFI DG SANCO 2007 use levels provided to JECFA e OFI JECFA 2010 use levels
2. FACET Data My Data near the top left of the program window By default the program window opens to a default size You can resize the window to the desired size though to ensure adequate display of all features there is a minimum allowed size for the window FACET Internal Document Copyright Creme Software Ltd Data Structures The FACET software supports a number of probabilistic data structures in the form of parametric and empirical distributions In general these can be used in place of point values for inputs such as chemical concentrations contact areas etc A table of the possible options 1s below Distribution Type Arguments argumens Examplet ___ Distribution Type Arguments uniform 1 5 gaussian 23 1 Normal Distribution With Bounds 4 Mean S D min max gaussian 23 1 22 24 The choice distribution 1s used when a set of values are all equally likely The weighted distribution is used when different values occur with a given weight or frequency in the form of weight value weight value Note that the sum of the weights do not need to be less than zero or sum to one In general these can be nested within each other e g the individual elements of a weighted distribution can be composed of normal distributions we1ghted 0 2 gaussian 2 5 0 8 gaussian 1 3 FACET Internal Document Copyright Creme Software Ltd 6 Home The Home tab comprises e P
3. w Select Packaging Wizard w Select Substance Search meat Add Food Categories Food Code Description w Specify Coating E P8 Select Food Categories E P81 Table Options e E P8 2 EI P 8 3 E P18 E P 18 5 Meat and meat products Fresh Meat Fresh meat Processed meat products Processed meat and meat products Coated battered meat and meat products Preserved meat and meat products Frozen Meat amp Meat Products Unprocessed frozen meat and meat products Frozen meat substitutes Composite foods Ready Meals Frozen processed red meat amp poultry Meat pies and quiches Figure 97 Search for food category At the top of the new panel select the market share the component has in that food category by entering the appropriate value in the box a Enter the volume of the pack the new component will be used with Enter the rate of migration of the substance into the food in mg cm This value can also be a parametric distribution Add Food Categories Search meat P 8 Meat and meat products x Ms Food Code Description an a pg Y Meat and meat products Market share 100 00 P81 Fresh Meat Pack size 0 00 BE a Fresh meat Substance migration rate mg dm E P8 2 Processed meat products Processed meat and meat products Coated battered meat and meat products q Preserved meat and meat products E P83 Frozen Meat amp Meat Products Unprocessed frozen meat and meat products Froze
4. e Survey Used to alternate between different dietary surveys in a an exposure assessment This has a radio button type filter FACET Internal Document Copyright O Creme Software Ltd 15 e Substance Food Used to alternate between displaying exposure to a substance or intake of food This has a radio button type filter e Intake Type The type of exposure which can be Absolute measured in mg per day or Per unit body weight measured in mg per kilogram of bodyweight per day This has a radio button type filter e Consumer Type There are two possible consumer types Food Consumers and Total Population As these cannot be plotted together each consumer type appears in a separate graph This has a checkbox type filter e FACET Category Code This allows you to decide which FACET food categories are displayed by their numerical food code This has a checkbox type filter e FACET Category Name This allows you to decide which FACET food categories are displayed by their food description This has a checkbox type filter e Statistic Shows what population statistic is plotted e g mean P90 P95 etc This has a radio button type filter When a distribution chart type is selected this filter provides the option of displaying a PDF or CDF chart type A File Changes New Help X E we Wj x Home m Assessments E FACET Data E My Data Results El10 in E110 Per unit body weight Total Populatio
5. facet FACET Exposure Assessment Tool User Manual Version 2 0 6 December 2013 gt Creme FACET Internal Release Copyright O Creme Software Ltd Contents S YST NI REQUIEM aa 4 Release NOTES at tod tos cd 4 CTV A N A DOA A DOME V Nn n 5 Data SUUuc ures A S a N C A eon E AG a eee 6 A RR O 7 PASSES MMS o a cos 8 Organising ASSESSIMEINS a A A A A AA 10 Creatine a NEW Older da IA 10 Rename a TOC eoa T E A E LAOR APARIAR Tolen 11 Derim aT olde eeaeee E ATAMA BA 11 Renaming an Assessment aia a atan 11 Deletins am Assessment ana E R AAA 12 WAC WIS ME RE POM sennen a E EAE 12 IVC UDCA Gaia ie hea oes as tahoe a a bt 12 VACWING Gap id a 13 Viewing Dala Olsson aleta 17 Wie wine ANRl aa 18 Rinitis an Assessment ire osa sata 19 DIESE ASSESSMENT PE a Na as 21 NI A E E a eens AN CR A Le din ee 21 Searenine Tora UD ICO iii adi 22 FIAV OULA SS ic ideo cai DAL N TTT deba 22 AddItiNne sega a E A dA Eu be ENGA 20 arde 00 23 Packagine ST a Aia 24 A A A A O RALA A seat eect AL AN LO AAA AA oe SELLE Ge eee 25 Usme Custom Concentration Dita a a 26 Selec Concentracion Dalai 26 Select PACK HV PES ica aaa 21 A O e 28 SEICCLES UEY Cy O NT 32 Select Population Fitters ena e NARA 34 Assessment Options sitas 35 Flavourins Assessment Ops e E 36 Additive Assessment Options is bd 00024 Cendet 37 Packaging Assessment Options a 38 Advanced ODIOS da 39 ASSESSMENTS UMIA V a a E A 40 FACETO aa E E E ee nee a eee 42 Hasan 43 FOO C
6. E110 Per unit body weigh Total Population A2 FATS AND OILS AND FAT EM Mean 0 mg kg bw 0 1906 Irish NTFS 200 F110 Per unit body weigh Total Population A3 FRUITS NUTS AND SEEDS Mean 0 000357 mg kg bw 9 60646e 005 1994 Irish NTFS 200 E110 Per unit body Pa Total Population A4 VEGETABLES STARCHY ROO Mean 0 000938 mg kg bw 0 000106893 2082 Irish NTFS 200 E110 Per unit body weigh Total Population AS CHOCOLATE PRODUCTS AN Mean 0 001111 mg kg bw 6 54223e 005 2170 Irish NTFS 200 E110 Per unit body N Total Population A6 CEREALS AND CEREALS PROL Mean 0 mg kg bw 0 2258 Irish NTFS 200 E110 Per unit body weigh Total Population A7 BREADS AND BAKERY WARES Mean 0 003883 mg kg bw 0 000126992 2346 Irish NTFS 200 E110 Per unit body weigh Total Population A8 MEAT AND MEAT PRODUCT Mean 0 mg kg bw 0 2434 Irish NTFS 200 E110 Per unit body weigh Total Population A9 FISH AND FISH PRODUCTS h Mean 0 mg kg bw 0 2522 Irish NTFS 200 E110 Per unit body weigh Total Population A 10 EGGS AND EGGS PRODUCTS Mean 0 mg kg bw 0 2610 Irish NTFS 200 E110 Per unit body weigh Total Population ___ A1 SWEETENERS AND HONEY Mean mg kg bw 0 Figure 12 Filters available e Checkboxes This filter type applies to data that can be plotted simultaneously e g FACET food categories e Radio Buttons This filter type applies to data that cannot be plotted simultaneously e g the Statistic column Each filter type is described in detail below
7. 112310 SS edi 43 MierationIntTotniatio nt said 46 SUDSTANCE rasa 47 A AA ae erecta sear ale ara a ence ins ose poo a NE 48 Screening Calcula lOs rental io 51 FACET Internal Document Copyright O Creme Software Ltd 2 PCI NI TO Sate C d TE ORE R DAS 2 chee d S D RE ase 51 BT AEA pocitos ii 16 EY CY Sasser tee t rate aca i A Ae AA NO A A A A AC AO ND AC C A hc 57 MY Dali egeria an Ea oa canas 59 Manage Dalai 59 Navigating about the data Mandato 59 Cheatin a NEW TOLE re tato yal aya E A ao bate cat 60 Rename Old cer tao it aria 60 Delctino a tod a adoos 60 ING We rable Wizarde ii 61 The DUVE dO enea darte id TATO iia 61 LESS u ROW oriai P ci 62 Deli ROW ide 63 EMS dat dianas 64 Advanced Packasine Interracial o iodo A ii ida 67 NEW Pack DE 68 Metal Pack TDS T SAA o O UE 5 M227 YE ET 85 OUEN EN A 85 Restart iNe Sonwa Onna a E 01321 a3AtituaiL AU A be 85 Close FACET using the Task Manager oocccccncccnnnnnonncnnnnnnnonononnnnnnnnnnononnnannnnncnnnnnnnnnnnos 85 Uninstall ane remsa FACET 2253220259023020 aa 86 FanSite ADON eee etna mre ero en eaters E Mean tee A2 en ee ae 21 86 FACET Internal Document Copyright Creme Software Ltd 3 System Requirements This software will run on machines using the Microsoft Windows XP Windows Vista or Windows 7 operating systems The user must have administrator privileges on their PC to install this software Approximately 1GB of disk space is required for installation of th
8. 2013 18 29 4 Dec 2013 18 32 4 Dec 2013 18 38 4 Dec 2013 18 45 4 Dec 2013 18 50 E Flavourings Z Packaging Finland H H France Hungary No preview available for this file Al H Ireland A H Italy Poland 4 w Figure 60 Surveys folder This allows you to view the various surveys available in FACET The available surveys are the same as those that appear in Step 7 of the New Assessment Wizard The visible fields are e Name The name of the survey e Years The years in which the survey was carried out e Subjects The number of subjects in the survey e Age Range The range of ages of subjects in the survey e Methodology The methodology used to carry out the survey e Record The type of dietary records that appear in the survey FACET Internal Document Copyright O Creme Software Ltd 57 El ES FACET Data E Flags S Food Categories 9 Migration Information El S Substances El ES Additives ES Additive Info E Additive Ingredient Distributio S Flavourings E Packaging E ES Surveys Finland H H France Hungary Ui H Ireland E H Italy Poland EN Portugal eS UK Template Tables FACET Internal Document Name 1 Row Count 1 Date Accessed da UK NDNS 1992 1 4 9 Aug 2012 15 59 P UK NDNS 1995 Over 6 9 Aug 2012 15 59 fF UK NDNS 2000 19 64 9 Aug 2012 15 59 ga UK NDNS 1997 4 18 9 Aug 2012 15 59 UK NDNS 2000 19 64 2000 2001 1724 19 64 7 day weighed food diary Person Day Eating occasion F
9. 27 12 37 S Packaging Feb 28 09 10 Feb 27 12 37 Figure 46 Substances folders Flavourings The flavourings folder contains tables of all of the flavourings data in FACET There are two subfolders the Flavouring Info folder and the Screening Calculations folder File Go New Help R gt 4 5 Assessments F FACET Data E FACET Data Mame 1 Date Accessed 1 Date Created Flags Flavouring Info 20 Aug 2012 16 28 20 Aug 2012 14 46 S Food Categories E Screening Calculations 20 Aug 2012 16 28 20 Aug 2012 14 46 Migration Information E Substances El E Additives E Flavourings Flavouring Info Screening Calculations E Packaging E Surveys No preview available for this file Figure 47 Flavourings folder Flavourings Info This folder contains tables detailing all the information on flavouring concentrations and other information The flavourings table simply called Flavourings contains information on all the different flavouring substances in FACET Clicking on the table once will bring up a preview in the bottom right pane showing a search box for browsing different fields The table contains the following fields FACET Internal Document Copyright O Creme Software Ltd 48 Plawis Number Y Flavis Mumber COE No FEMA No Jecfa MN T Flavis Mame Mamets Menthol 63 427 NE Borneol CAS Number 64 2157 1385 M Cinnamyl alcohol CoE Number 65 2204 647 A Merolidol FE
10. Assessment Options Assessment Summary Assess using 9 Typical Minimum Typical Maximum Extreme Minimum Extreme Maximum Fitted Distribution MPL Include occurrence data Advanced Options a rece G coccccc00c00000000000000000000000000006 FACET Internal Document Copyright Creme Software Ltd 37 Figure 36 Additive options Assess using The exposure assessment can be performed using e Typical minimum concentrations e Typical maximum concentrations e Extreme minimum concentrations e Extreme maximum concentrations e Fitted distribution e Maximum Permitted Levels MPLs The first five options only apply to the 32 target additives and are based on data supplied by industry Packaging Assessment Options Consumer loyalty For a packaging assessment you can choose to perform the assessment with without or both with and without consumer loyalty model this appears in the advanced options for the other assessment types SetOff If the substance in the assessment has been pre populated with set off then at this point the user has the option to run the assessment with set off Otherwise the user will not be allowed to check the Use SetOff option Exclude homegrown homemade foods Consumption events described as involving homegrown foods are ignored Exclude restaurant canteen foods Consumption events described as involving restaurant or canteen foods are ignored FACET Internal Document C
11. Creme Software Ltd 40 After reviewing the choices you can choose to start an assessment using the Run button at the bottom right of the window At the bottom of the summary the estimated time for the assessment to run is shown In order to start the assessment you must first check the box indicating that you understand that your computer will be busy for the time taken to run the assessment Equally you may wish to make changes to the selections Navigation to the appropriate steps to do this is easily achieved with the buttons on the left of the tab FACET Internal Document Copyright O Creme Software Ltd 41 FACET Data The FACET data tab allows you to view but not edit FACET data used in performing exposure assessments Note that raw concentration data packaging data and consumption diaries will be hidden from the user at all times File Go New Help Es Assessments FACET Data My Data E FACET Data 4 Date Accessed 4 Date Created Flags a A 0504 3 7 21052 NOONE ERRA NA EA Food Categories Food Categories 16 Jul 2013 15 15 18 Jun 2013 17 12 E Migration Information Migration Information 16 Jul 2013 15 15 18 Jun 2013 17 12 E Substances E Substances 16 Jul 2013 15 15 18 Jun 2013 17 12 F E Surveys E Flags 16 Jul 2013 15 15 18 Jun 2013 18 15 No preview available for this file Figure 39 The FACET Data Tab The tab is implemented in a three pane layout The upper pane contains folders
12. Dec 2013 18 55 4 Dec 2013 18 55 No preview available for this file El E FACET Data E5 Flags E5 Food Categories E Migration Information E Substances E Additives E E flavourings E Flavouring Info 4 Date Accessed 20 Aug 2012 17 46 4 Date Created 20 Aug 2012 15 16 SD Screening Calculations m Packaging E Surveys Figure 58 Packaging Folder FACET Internal Document No preview available for this file Copyright Creme Software Ltd The packaging folder contains one table called Packaging Substances showing a complete list of all the packaging substances available in FACET The table contains the following fields e FACET ID This is strictly a four digit number with no leading zeros e g 1021 This is the unique identifier of the migrant e CAS Number This is strictly of the form up to 7 digits 2 digits 1 digit e g 64 17 5 or 0000064 17 5 e Chemical Name The chemical name s of the substance e Alternative Name Any other alternative names that might be associated with the substance e Molecular Weight Molecular weight of the migrant Strictly a numeric field FACET _ oe o x File Go New Help eo Home Assessments E FACET Data My Data Screening Calcul E E FACET Data Name 4 Date Accessed 4 Date Created Flags 2 Packaging Substances 20 Aug 2012 17 46 20 Aug 2012 15 16 SD Food
13. Y Flagi Code 4 Retail incl over the counter Take away vending fast food Restaurant canteen Homegrown Homemade Figure 75 Facet flag settings FACET Internal Document Copyright Creme Software Ltd 66 Advanced Packaging Interface File New Help Als V New Assessment en Q New Packaging Wizard New Table Figure 76 Advanced packaging interface using wizard icon New Help New Assessment New Packaging Wizard New Table Figure 77 Advanced packaging interface using new menu The advanced packaging interface can be used to investigate the impact of bringing a new packaging structure material or packaging type to the market from the point of view of consumer exposure To open the advanced packaging interface click on the wizard icon and select New Packaging Assessment or select New Packaging Assessment from the New menu There are two assessment types in the New Packaging Wizard 1 New Pack Type 2 New Metal Pack Type FACET Internal Document Copyright O Creme Software Ltd 67 Select Packaging Wizard Select Packaging Wizard New Pack Type New Metal Pack Type Figure 78 Packaging Assessment home page New Pack Type Select Packaging Wizard Select Packaging Wizard Select Substance Specify Layers Select Food Categories Table Options l lt New Pack Type New Metal Pack Type Figure 79 New pack type assessment FACET Internal Document
14. chosen from the list of built in substances displayed at this step By default the option Use pre installed FACET data is selected Use pre installed FACET data This is simply done by clicking anywhere on the row containing the substance of interest or on the radio button next to the substance ID FACET Internal Document Copyright Creme Software Ltd 21 The list of substances may also be searched to find the substance of interest This search procedure is explained in detail below for each assessment type Alternatively you can use your own table of concentration data to use in an assessment by selecting the Use my concentration data option Use my concentration data This involves populating your own table of concentrations beforehand See New Table Wizard in the My Data section of the manual for more details on how to do this Searching for a Substance Select Flavouring w Select Assessment Type Use pre installed FACET data Select Flavor C i elect Flavouring Search Flavis Number z Clear Select Concentration Data Select Food Categories FINo Flavis Name CASNumber CoE ae Targi In Re 2015 Menthol 89 78 1 63 Name s 2016 Borneol 507 70 0 64 CAS Number 2017 Cinmamyl alcohol 104 54 1 E prada 2018 Nerolidol 7212 44 4 gi EMA Numbes 2019 2 Phenylethan 1 ol 60 12 8 6g JECFA Number 2020 Hex 2 en 1 ol 2305 21 7 69 2562 1354 2021 Heptan 1 ol 11
15. eo FACET Data E amp FACET Data Name 4 Date Accessed 4 Date Created ES Flags J Additives Food Hierarc 16 Jul 2013 16 54 18 Jun 2013 17 12 a Food Categories Flavourings Food Hiera 16 Jul 2013 16 54 18 Jun 2013 17 12 E Migration inca ZJ Packaging Food Hierar 16 Jul 2013 16 54 18 Jun 2013 17 13 E E Substances E Additives E3 Flavourings Packaging E E Surveys Finland H l France Hungary F Ireland Ui H Italy No preview available for this file Poland NM Portugal SE UK lt mmm ae dl Figure 41 Food Categories Folder Clicking on each table causes it to appear in the pane below The fields in each table are e Category Code e Category Name FACET Internal Document Copyright Creme Software Ltd 44 FACET Data Name r Date Accessed 4 Date Created q J Additives Food Hierarc 16 Jul 2013 16 54 18 Jun 2013 17 12 18 Jun 2013 17 1 L Packaging Food Hierar 16 Jul 2013 16 54 18 Jun 2013 17 13 Search Clear gt Code Category Name F1 Dairy products and analogues including ingredients of composite foods E 1 F 2 Fats and oils and fat emulsions including ingredients of composite foods E F 3 Fruits nuts and seeds including ingredients of composite foods E F4 Vegetables starchy roots legumes and seaweeds including ingredients of composite f e F 5 Chocolate products and confectionery including ing
16. food codes flag settings and presence probabilities Concentrations FACET Internal Document Copyright O Creme Software Ltd 64 To enter a concentration value for a given row note that the units are in mg kg 1 Double click on the cell with the header Concentration 2 Entered the concentration data and press return The value entered can be a number or a parametric distribution 3 Changes to the table are saved automatically File Changes New Help t P 10 323 Ww Home l Assessments FACET Data My Data New Table O E Y FACETC Y FACET Description Y EuCo Y Additive Na 4 Concentration mg kg C 4 Al DAIRY PRODUCTS AND AN E110 Sunset yellow FCF 12 2 4 Figure 72 Enter concentration data Presence Probabilities To enter a presence probability for a given row note that the value should be between O and 1 1 Double click on the cell with the header Presence Probability 2 Changes to the table are saved automatically File Changes New Help k P 2 Q 1 7 9 G Home Assessments FACET Data My Data New Table O FACETC 4 Y FACET Description 4 Y EuCo Y Additive Na 4 Concentration mg kg 4 Presence Probability ai 1 DAIRY PRODUCTS AND AN E110 Sunset yellow FCF 12 2 0 6 Figure 73 Enter presence probability Food Codes FACET food codes can be entered at any level in the hierarchy and ca
17. on the substance and database chosen you have a number of options for a flavouring assessment Assessment Summary Assess using Typical use levels Upper use levels Fitted Distribution Exclude foods without added flavourings Exclude unprocessed fruits nuts and seeds Use probability of addition data val Flavouring source Added and Natural Added Only Natural Only Advanced Options Figure 35 Flavouring options FACET Internal Document Copyright O Creme Software Ltd 36 Assess using The exposure assessment can be performed using either e Typical use levels e Upper use levels e Fitted distribution a parametric distribution fitted to the typical and upper use levels Exclude unflavoured foods Consumption events described as being without added flavourings are ignored in the exposure assessment Exclude homemade foods Consumption events described as being homemade are ignored in the exposure assessment Use probability of addition data Use probability of addition data for flavourings that have this value assigned only applies to the target flavourings in FACET Flavouring source Assess exposure due to e Added and natural e Added only e Natural only The option for assessing exposure due to natural occurrence only applies to the target flavourings in FACET Additive Assessment Options Depending on the substance chosen the user has a number of options for an additive assessment
18. organised and is similar to any file management system The view is implemented in a three panel layout The left hand pane shows a tree structure that shows how the user s folders are organised File Edit Go New Help 1 69 4 a Home Assessments FACET Data My Data Results New As E E Assessments Name 4 Progress 4 ID 4 Date Created a 8 My Assessments l E110 in IRE UK teens Complete 592 16 Jul 2013 12 5 su Sample Assessment No preview available for this file Figure 2 The assessment tab The top right panel shows the contents of the folders which are assessments The assessments are presented in a list view and the following fields are displayed e Name The name given to the assessment by the user e Progress This is a progress bar showing what percentage of the assessment has been completed e ID The unique ID number of the assessment e Date Created The date the assessment was run e Date Accessed The date the assessment was last viewed FACET Internal Document Copyright Creme Software Ltd Name Progress ID 4 Date Created rr EEE EEE EEE EEE EEE EE EEE EEE EEE EEE EE EEE EEE EEE EEEE EEE EEE EEE EE EEEEE EEE EEE EEE EE EEE EEE EEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE EEE EEE EEEEEEEEEEEEEEEEEEE EEE EEE EEE EEE EEE EEE EEE EEEEEEEEEEEEEEEEEEEEEEEEE EEE EEE EEE EEE EERE EEE EES FERRER EERE EERE EEE EEE EERE EEE EEE EEE EEE EERE EEE EEE EE
19. 1 70 6 70 2548 94 2022 Octan 2 ol 123 96 6 2801 289 Select Surveys Assessment Options Assessment Summary lt T No substances selected Use my concentration data rSelect Concentration Table Name 4 Date Created 1 Date Accessed My Additive Data ee Ay Flavouring Data E My Migration Data Figure 19 Available search fields for Flavourings Flavourings FACET Internal Document Copyright O Creme Software Ltd 22 The available search fields for substances assessed as flavourings are Flavis Number CAS Number Name s COE Number FEMA number and JECFA number Instant searching is enabled in all fields That is as you enter search criteria into the search box search results are returned at each key stroke A new search can be performed by either deleting what is in the search box or clicking on the Clear Search button e Flavis Number Numeric field the number assigned by FLAVIS the EU Flavour Information System This is strictly a four or five digit number and is the only unique identifier of flavourings in the FACET project e CAS Number This is strictly of the form up to 7 digits 2 digits 1 digit e g 64 17 5 or 0000064 17 5 e Name s This searches both the Flavis Name and Alternative Name fields e CoE Number Council of Europe Number This is strictly a numeric field but can be any length e FEMA Number Flavour and Extract Manufacturers Association This
20. 2 methyl 2 1 C7H13M10451 00000791 Acrylic acid Polyacrylic Acid CSH402 0007495 3 Acrelic acid Renrvlacmwlate CIOHINO Figure 92 Create new substance New Substance 1 Enter the name of the additive in the box provided 2 Select whether the substance is polar medium polar or non polar from the drop down menu 3 Enter the molecular weight of the substance Existing Substance 1 Search for the name of the substance in the search box provided 2 Select the substance from the list FACET Internal Document Copyright Creme Software Ltd 78 9 Existing Substance des FACET Code CAS Number Chemical Mame Alternative Name Molecular Formula Molecular weigh 1004 0061788 Acids Fatty 1005 OO68783 Acids Fatty 1006 0000079 Acrylamide 1007 0015214 2 Acrylamid 1008 OO00079 Acrylic acid 1009 0002495 Acrylic acid 1010 0000141 Acrylic acid 1011 0002998 Acrylic acid 1012 O001663 Acrylic acid O O O O O O O Mothing selected Fatty acids C C36H6804 564 Fattw acids C 0 2 propenamide C3H5N101 71 2 methyl 2 11 C7H13MN10451 Polvaervlic Acid C3H402 Benzyl acrvlate C10H10012 n Butyl acrvlat C7H1202 sec Butyl met CFH1Z02 tert Butyl ary C7H1202 111 Figure 93 Search for existing substance Once all the steps have been completed click the Run button 2 Specify Coatings This is wh
21. 200 110 Per unit body weigh Total Population A6 0 ma ka b 0 0 0 0 0 CEREALS AND CEREALS PROI Mean n Figure 9 Results viewer Column Chart and Data There are four available views three graphical views column charts pie charts and distributions and a data view To toggle between the views click on the different graph icons or the data icon in the toolbar Viewing Graphs By default the assessment results appear with graphical views of the exposure assessments are presented above the data grid The content of the graphs is controlled by the filters on the data grid fields To control the type of graph being displayed click on the different graph icons in the tool bar There are three graph types FACET Internal Document Copyright Creme Software Ltd 13 Column Chart A chart with vertical rectangular bars with lengths proportional to the values that they represent The level of exposure is on the y axis and the FACET food category is on the x axis Si Pie chart A circular chart divided into sectors illustrating proportion The arc length of each sector is proportional to the quantity it represents The chart is displayed with a legend on the right hand side and only applies to the mean statistic in the total population File Changes New Help R gt i t ty u O x A Home E Assessments E FACET Data m My Data Results E110 in E110 Per unit body weight Total Population Mean Z A 3 FRUITS NU
22. 3 7 T Irish NSIFCS 1999 Select Surveys Assessment Options Assessment Summary YA a Irish NTFS 2005 E i ltaly EN Portugal Figure 31 Example of country with multiple surveys and selecting two surveys to compare Select Population Filters Here you also have the option of using gender and age population filters for your assessment Selecting one or more of these filters allows you to perform an assessment on that subset of the population For gender you can specify whether the subjects of interest are male female or both The All option is selected by default For age you have the following options from the drop down menu e Between specifying upper and lower limits inclusively e Less than e Greater than The user can then enter numeric values relating to the filter chosen from the above list FACET Internal Document Copyright O Creme Software Ltd 34 Gender Vi Male Female Age years Between Ly 0 and 97 Between Size 1068 Less Than Greater Than Previous Next Figure 32 Selecting population filters Note that for an assessment involving multiple surveys the age filters are applied across all surveys simultaneously so some age bands may not apply to a given survey Assessment Options In the basic view you are given the option of naming your assessment and providing a description of the assessment You can name your assessment and choose a location for it in the A
23. 7 Migration Information ES Substances E Surveys E Template Tables Search Clear Code Category Name M 1 Not Known M 2 Metal E M3 Paper Board 3 M31 case materials 3 M 3 2 Carton board M 3 2 2 Solid unbleached board SUB or SUS M 3 2 3 Folding box board FBB or GC2 M 3 2 4 White lined chipboard WLC or GD2 3 M33 Wrapping paper M3 4 Other paper and board for packaging 4 M3 5 Special paper and board non packaging M4 RCF E MS Other non plastic M6 PE M7 EVOH M8 Ionomer n nan Figure 45 Material Code Table The material codes can be viewed as a tree and clicking on the arrow in each category causes the contents of that category to be displayed which in turn can be displayed You can also search the data using the search box that appears between the panes The Pack Type Hierarchy table shows the pack type descriptions contained in the Main Closure Outer and Insert components of food packaging It is in a hierarchy in the same form as the Material Hierarchy table Substances This view provides a list of all substances in FACET There are three folders each of which is described in detail below Double clicking on any of the tables will open a data view of that table for so that the content can be browsed easily FACET Internal Document Copyright O Creme Software Ltd 4 Mame 1 Date Accessed 1 Date Created Additives Feb 28 09 10 Feb 27 12 37 Plawourings Feb 28 09 10 Feb
24. Categories Migration Information E ES Substances ES Additives 3 E Flavourings ES Flavouring Info Screening Calculations E3 Packaging Search FACET ID gt Search Clear oe Surveys FACET IC CAS Number Chemical Name Alternative Name dbaaan ormula Molecular Weight 1000 0000064 19 7 Acetic acid Ethanoic acid AS 60 1001 0000108 05 4 Acetic acid vinyl ester Vinyl acetate Name s 86 1002 0000108 24 7 Acetic anhydride Molecular Formula 102 1003 0000074 86 2 Acetylene Molecular Weight 26 1004 0061788 89 4 Acids fatty unsaturate Fatty acids C18 unsatd dimers C36H6804 564 1005 0068783 41 5 Acids fatty unsaturate Fatty acids C18 unsatd dimer 0 1006 0000079 06 1 Acrylamide 2 propenamide C3H5N101 71 1007 0015214 89 8 2 Acrylamido 2 meth 2 methyl 2 1 oxo 2 propen C7H13N104S1 Figure 59 Packaging table search box FACET Internal Document Copyright Creme Software Ltd 56 Surveys File Go New Help K 4 4 E ES FACET Data Flags Food Categories E Migration Information El ES Substances E E Additives E Additive Info 3 Additive Ingredient Distribu _ FS FACET Data 8 UK Hungary H H France Poland Finland A Ireland l H Italy Portuaal 1 Date Accessed 6 Dec 2013 09 46 6 Dec 2013 09 46 6 Dec 2013 09 46 6 Dec 2013 09 46 6 Dec 2013 09 46 6 Dec 2013 09 46 6 Dec 2013 09 46 6 Dec 2013 09 46 1 Date Created 4 Dec 2013 17 42 4 Dec 2013 17 57 4 Dec 2013 18 00 4 Dec
25. Copyright O Creme Software Ltd 68 The new structure option assesses the impact of bringing an entire new packaging configuration to market The predicted migration of an additive from the components in the packaging into relevant foods is assessed and outputted to a database for use in an exposure assessment There are three steps to complete 1 Select Substance Here you can choose the substance whose level of migration you want to assess You can perform the assessment with a new substance or an existing substance Select Substance w Select Packaging Wizard New Substance Substance name Additive x Specify Layers Log P C 1 2674 Select Food Categories Molecular Weight 64 00 mol Table Options Existing Substance Clear FACET Id CAS Number Chemical Name Alternative Name Molecular Formula Molecular Weight 1000 Q000064 1 Acetic acid Ethanoic acid C2H402 60 1001 0000108 0 Acetic acid v Vinyl acetate C4H602 86 1002 0000108 2 Acetic anhyd C4H603 102 1003 0000074 8 Acetylene C2H2 26 1004 0061788 8 Acids fatty u Fatty acids Cl C36H6804 1005 0068783 4 Acids fatty u Fatty acids Cl 1006 0000079 0 Acrylamide 2 propenamide C3HSN101 1007 0015214 8 2 Acrylamido 2 methyl 2 1 C7HISNLO4 1 1008 0000079 1 Acrylic acid Polyacrylic Acid C3H402 Nothing selected Figure 80 Create new substance New Substance 1 Ente
26. Data E My Data 4 Progress 4 Row Count Create Folder Figure 63 Example of own data table and creating new folder FACET Internal Document Copyright O Creme Software Ltd 59 Creating a new folder 1 To create a new folder right click on where you want to create it in the right pane and select Create Folder 2 This will bring up a dialogue box into which you can enter the name of the new folder 3 After entering the name of the new folder click on OK and the new folder will be created Renaming a folder 1 Torename a folder right click on the folder you want to rename and select Rename Alternatively you can select the folder and choose Rename from the Edit menu 2 This will bring up a dialogue into which you can enter the new name of the folder Enter the new name of the folder into the dialogue and click on Rename O FACET Data 5 My Data Name Progress 1 Type E own data tab Table bd Open Rename X Delete Figure 64 Renaming a folder Deleting a folder 1 To delete a folder right click on the folder you want to rename and select Delete Alternatively you can select the folder and choose Delete from the Edit menu FACET Internal Document Copyright O Creme Software Ltd 60 New Table Wizard To create a new table in the My Data tab you can use the New Table Wizard This can be selected from the New menu or by clicking on the wiza
27. MA Number 67 2772 h 2 Phenylethan 1 ol JECFA Number 68 2858 987 M Hex Z en 1 cl 2305 21 7 69 2562 1354 ho TT gt H Figure 48 Search options for flavouring data Flavis Number Numeric field the number assigned by FLAVIS the EU Flavour Information System Flavis Name The name assigned by FLAVIS the EU Flavour Information System CAS Number Chemical Abstracts Service This is strictly of the form up to 7 digits 2 digits 1 digit e g 64 17 5 or 0000064 17 5 CoE Number Council of Europe Number This is strictly a numeric field but can be any length FEMA Number Flavour and Extract Manufacturers Association This is strictly a numeric field but can be any length JECFA Number Joint FAO WHO Expert Committee on Food Additives This is strictly a numeric field but can be any length Target Flavouring Yes No field In Register Yes No field Evaluation Status Whether evaluated or not and by whom Short Reference Reference to when the flavouring was assessed Synonymous Any synonyms for the flavouring Remarks Any further information about the flavouring There are 15 other tables in this folder Flavourings Refined The probability of addition of the target flavourings in difference FACET food categories and refined use levels where known Flavourings EFFA Upper and average use levels from the European Flavour Association in both the FACET and EFFA food categories Flavourings FEMA Upper and aver
28. Progress 2 E110 in IRE UK teens Complete bj Open Zi Rename X Delete Figure 7 Renaming deleting a folder Renaming an Assessment 1 Torename an assessment right click on the assessment you want to delete and select Rename from the context menu FACET Internal Document Copyright O Creme Software Ltd 11 2 Alternatively select the assessment you want to rename and choose Rename from the Edit menu Deleting an Assessment 1 To delete an assessment right click on the assessment you want to delete and select Delete from the context menu 2 Alternatively select the assessment you want to delete and choose Delete from the Edit menu 3 Note that if the assessment is running you can still delete it Viewing the Report To view the report generated by the software 1 Navigate to where the assessment is located in the assessment manager and click on it 2 Asummary of the assessment will appear in the bottom right pane 3 Click on the View report button in the top right hand side of the preview pane This will bring up the report viewer showing a summary of the report and some basic statistics 4 Toprint the report click on the Print button in the top right left hand corner of the report 5 To save the report in PDF format click on the Export button in the top left hand corner of the report Viewing Graphs To view graphs and statistics generated by an asses
29. RE EEE EEE EEE EEE EERE EERE EEE EEE EEE EE EEE EEE EEE EE EEE EEE REESE EEE EEE EEE E EEE EEE EE EEE EEE EE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE EEE Eee EET ET 4 TT t Figure 3 List view of assessment The bottom right panel provides the status and details of whatever assessment is selected in the top right pane It also provides buttons that allow the user to view the results of the selected assessment View All Results view the graphs of the assessment View Graphs or view the report generated by the assessment View Report Descriptive fields appear in the assessment summary showing the following File Edit Go New Help gt 4 4 Home Assessments FACET Data l My Data E amp Assessments Name 4 Progress 4 ID 4 Date Created 4 Date Accessed E My Assessments Sample Ax Curcumin in Irish population All foods Complete 621 8 Aug 2012 12 29 16 Aug 2012 08 52 P Sample Ax 9024 in French males lt 20 yr old All foods Complete 625 8 Aug 2012 12 35 16 Aug 2012 08 52 Assessment Summary 625 Sample Ax 9024 in French males lt 20 yr old All foods Description Fitted distribution lognormal Type Flavouring FEMA Substance 9024 Isopentyl acetate Survey s Name Filtered Population Size Simulated Population Size FranceINCA2 740 740 Population Filters Gender Male Age between 0 and 20 Date Subm
30. T means that the substance was pre populated without set off In the second case WITH means that the substance was pre populated with set off The third option BOTH signifies that the substance was pre populated both with and without set off Select Migrant w Select Assessment Type Use pre installed FACET data Select Migrant Search 14 FACET ID y Clear Select Pack Types Select Food Categories FACET IE CAS Number Chemical Name Alternative N Select Surveys 1401 0000103 23 1 Adipic acid bis 2 ethylhexyl ester Adipic acid c Assessment Options 5 1443 0000119 61 9 Benzophenone Benzene ber Assessment Summary No substances selected Use my concentration data Select Concentration Table Name 4 Date Created Date Accessed ES My Additive Data E My Flavouring Data My Migration Data E My Packaging Data Use in combination with pre installed FACET data rr Cares a Figure 21 Searching for packaging substances Search Results The search results are returned instantaneously after each keystroke Once you find the substance you are looking for select it from the list and click on the Next button FACET Internal Document Copyright O Creme Software Ltd 25 Using Custom Concentration Data If you want to use a table of pre loaded concentration data select this option The folders in the My Data tab will be made visible and their contents displayed Select the table you want to use and click Next
31. TS AND SEEDS 0 18 E A 4 VEGETABLES STARCHY ROOTS LEGUMES AND SEAWEEDS 0 48 El A 5 CHOCOLATE PRODUCTS AND CONFECTIONERY 0 56 E A 7 BREADS AND BAKERY WARES 1 97 WI A 12 SALT SPICES SAUCES AND SOUPS 50 12 H 4 13 NUTRITIONAL FOODSTUFFS 0 65 IB 4 14 NON ALCOHOLIC BEVERAGES EXCEPT DAIRY BEVERAGES 45 37 IB 415 ALCOHOLIC BEVERAGES 0 67 M 4 17 DESSERTS EXCEPT BAKERY AND FRUIT DESSERTS 0 00 Y Survey Y Additive Food 4 Y Intake Type 4 Y ConsumerT 4 W FACET Category Co 4 W FACET Category Na 4 W Statistic 1 Value Units Standard Error 90 Cl Lower 4 90 Cl Upper 4 99 ClLower 99 Cl Upper 1730 irish NTFS 200 E110 Per unit body weigh Total Population Al DAIRY PRODUCTS AND ANA Mean 0 mg kg b 0 0 0 0 0 1818 Irish NTFS 200 E110 Per unit body weigh Total Population A2 FATS AND OILS AND FAT EM Mean 0 mg kg b 0 0 0 0 0 1906 Irish NTFS 200 E110 Per unit body weigh Total Population A3 FRUITS NUTS AND SEEDS Mean 0 0003571 mg kg b 9 60646e 005 0 0001919 0 000516376 0 000136364 0 000585495 1994 irish NTFS 200 E110 Per unit body weigh Total Population AA VEGETABLES STARCHY ROO Mean 0 000938 mg kg b 0 000106893 0 000773855 0 00113439 0 000673949 0 00120146 2082 Irish NTFS 200 E110 Per unit body weigh Total Population AS CHOCOLATE PRODUCTS AN Mean 0 001111 mg kg b 6 54223e 005 0 00101086 0 00122193 0 000963456 0 0012763 2170 Irish NTFS 200 E110 Per unit body w
32. age use levels from the Flavour and Extract Manufacturers Association in both the FACET and FEMA food categories Flavourings IOFI JECFA 2006 Flavouring concentration database Flavourings IOFI JECFA 2007 Flavouring concentration database Flavourings IOFI JECFA 2010 Flavouring concentration database Flavourings IOFI Flavouring concentration database FACET Internal Document Copyright O Creme Software Ltd 49 e Flavourings DGSanco Flavouring concentration database e Flavourings CoE Flavouring concentration database e Flavourings Smoke Flavouring concentration database e Conversion Factors Table of conversion factors for different food combinations e Flavourings Natural Flag Setting For a given flag shows for what foods with that flag setting are used to calculate a concentration value e Flavourings Natural Food Categories What food categories can occur as recipe fractions e Flavourings Natural Recipe Data What flags can occur as ingredient fractions e Flavourings Natural Flavouring concentration database The Conversion Factors table can be modified to assess the impact of changing different conversion factors The field that can be edited is in white In order to restore the default values click the Restore Default icon in the tool bar File Changes New Help X E ee Ordine FACET Code 4 Y FACET Descripti 1 Default Convers 4 Conversion Fact 4 Milk and dairy based drin 1 Milk p
33. ase exe FACET Scheduler exe FACET exe or FACET Engine exe and then click the End Process button NA FACET Internal Document Copyright O Creme Software Ltd 85 5 Repeat this process until all of the processes whose names begin with FACET have been terminated 6 Restart FACET as normal by selecting Start gt All Programs gt FACET 2 0 6 7 Ifthe issue is still unresolved proceed to the section Reset FACET Uninstall and reinstall FACET 1 If all of the above fails to resolve the issue it may be necessary to uninstall and reinstall FACET on your computer 2 On Windows XP Click on Start gt Settings gt Control Panel gt Add or Remove Programs On Windows Vista Click on Start gt Control Panel gt Programs and Featues On Windows 7 Click on Start gt Control Panel gt Uninstall a Program In each case you should see FACET 2 0 6 in the list of programs 3 Click on FACET 2 0 6 and select Uninstall or Remove This will remove FACET 2 0 6 from your computer 4 Using your web browser go to www cremesoftware com facet and follow the download and installation instructions for FACET 2 0 6 to create a fresh installation of FACET on your computer Failing all of the above If none the above successfully rectifies the issue please contact facet cremeglobal com and outline the problem Please mention the Operating System used and Service Pack e g Windows XP SP2 et
34. atically selected too Tri state checkboxes are also enabled whereby a square is shown in the checkbox to indicate the box is neither checked nor unchecked This is the case when some but not all elements of a particular category are checked Instant searching is enabled for the food groups That is as you enter search criteria into the search box search results are returned at each key stroke Sections that match the search are returned highlighted in yellow To search and select multiple foods you can simply search select foods of interest and search again The foods you selected will remain selected even if they are not displayed FACET Internal Document Copyright O Creme Software Ltd 30 Select Food Categories w Select Assessment Type Search sw w Select Additive Select All Code Category Name E E A3 FRUITS NUTS AND SEEDS E A3 2 Processed fruit E A 3 2 4 Canned and bottled fruit A3242 SWeet sour preserves of fruit E P A4 VEGETABLES STARCHY ROOTS LEGUMES AND SEAWEEDS a Fl A42 Processed vegetables E E A424 Canned or bottled or retort pouch vegetables A4244 Sweet sour preserves of vegetables E Fl A 4 2 6 Cooked or fried vegetables A4261 Vacuum packed SWeetcorn E AS CHOCOLATE PRODUCTS AND CONFECTIONERY E E A 5 3 Chewing gum and microsWeets FJ A531 Chewing gum with added sugars m A 5 3 2 Chewing gum without added sugars E A533 Breath freshening microsweets in the form of films A534 Other breath freshenin
35. c This information can be found by pressing the Windows Pause Break keys FACET Internal Document Copyright O Creme Software Ltd 86
36. cription a v Specify Layers P 2 Fats and oils and fat emulsions Jl Market share k 100 00 P3 Fruits nuts and seeds Pack size 0 00 g Table Options P 4 Vegetables starchy roots legumes and se P 5 Chocolate products and confectionery 0 gt seconds lt Time lt 07 seconds v 1 gt Y P 6 Cereals and cereal products 0 lt Temperature 0 Ta P 7 Bread and bakery wares r 0 seconds Y Time 0 seconds Y P 8 Meat and meat products 2 a c PO w Fish and fish products molluscs crustace o Temperature L 0 gt c F H a P 10 Eggs and egg products P 11 Sweeteners and honey P 12 Salt spices herbs sauces and soups P 13 Nutritional foodstuffs P 14 Non alcoholic beverages except dairy be P 15 Alcoholic beverages P 16 Ready to eat savouries P 17 Desserts except bakery and fruit desserts Cancel Previous Figure 87 Create food category O seconds Time O seconds 7 0 lt Temperature lt ME O seconds lt Time lt O seconds a 7 Y O Temperature a C Figure 88 Additional time and temperature added using plus symbol Remove using minus If desired factory storage can also be modelled To do this simply click the Include factory storage checkbox 4 Table Options This step
37. ct of bringing an entire new metal packaging configuration to market The predicted migration of an additive from the components in the metal packaging into relevant foods is assessed and outputted to a database for use in an exposure assessment There are three steps to complete 1 Select Substance Here you can choose the substance whose level of migration you want to assess You can perform the assessment with a new substance or an existing substance In both cases you need to enter the substance concentration in the material at the bottom of the page in mg kg This value can be a concentration or a parametric distribution FACET Internal Document Copyright O Creme Software Ltd re Select Substance w Select Packaging Wizard New Substance select Substance Substance name Additive x Specify Coatin i pany E Log P 4 45 Select Food Categories P Molecular Weight 103 00 E mal Table Options Existing Substance 7 FACET Id CAS Number Chemical Name Alternative Name Molecular Formula Molecular Weight 1000 0000064 1 Aceticacid Ethanoicacid C2H402 60 5 1001 0000108 0 Acetic acid v Vinyl acetate C4H602 86 1002 0000108 2 Acetic anhyd C4H603 1003 0000074 8 Acetylene C2H2 y 1004 0061788 8 Acids fatty u Fatty acids Cl C36H6804 2 1005 00687834 Acids fatty u Fatty acids Cl gt 1006 0000079 0 Acrylamide 2 propenamide C3H5N101 0015214 8 2 Acrylamido
38. cument Copyright O Creme Software Ltd 53 TFACET AS File Go New Help Ge 4 Assessments FACET Data e My Data 3 SS FACET Data Name 4 Date Accessed 4 Date Created E Flags _ Additives 6 Dec 2013 09 41 4 Dec 2013 18 52 ES Food Categories J Additives With Group Al 6 Dec 2013 09 41 4 Dec 2013 18 52 E Migration Information J Additives MPL 6 Dec 2013 09 41 4 Dec 2013 18 52 E Substances J Additive Occurence Prol 6 Dec 2013 09 41 4 Dec 2013 18 53 E E Additives E Additive Info E Additive Ingredient Distributio E Flavourings Packaging Search E Number Clear a ES Sure E Numbe Additive Name Has MPL JECFA Ev JE E Number gt by SCE ECE E100 Curcumin MPL a 2003 3 Name s 3 E101 Riboflavins MPL a 1998 0 5 Not spec E102 Tartrazine MPL a 1964 75 75 E104 Quinoline yellow MPL a 1984 10 0 5 E110 Sunset yellow FCF MPL a 1982 2 5 1 E1103 invertase No M 2001 Acceptable Acceptal 4 E mo t Figure 56 Additive table search box e E Number Number given by the EU This is the unique identifier of the additive e Name The name s of the additive e JECFA ADI Acceptable Daily Intake This field takes a combination of numbers and letters Units are listed in mg kg bw unless otherwise specified e JECFA Evaluation Numerical field showing the evaluation date Entries are in a four digit year type format e g 1991 e SCF EFSA ADI Acceptable Daily Intake This f
39. e software A processor with at least 1GHz clock speed and 1GB of RAM is recommended For optimum use of the software it is recommended to use a display with resolution of 1024 x 768 or higher Release Notes This software is the final implementation of the workflow features and functionality for the FACET exposure assessment tool This workflow has been refined and modified over time based on consortium feedback from FACET versions 1 0 January 2010 1 2 May 2010 1 4 October 2010 1 5 April 2011 1 6 February 2012 1 7 August 2012 1 8 October 2012 1 9 November 2012 2 0 August 2013 2 0 6 November 2013 The software contains all databases and models gathered and developed over the course of the FACET project FACET Internal Document Copyright O Creme Software Ltd 4 Overview The software is implemented in a four panel layout These four panels referred to as tabs are e Home dashboard providing program status and basic program information e Assessments interface to view results from completed assessments or the Status of assessments currently running e FACET Data interface to view non sensitive data that has been pre installed in the software e My Data interface to view data that the user has loaded into the FACET program On starting the software you will be presented with the Home tab a You can navigate between tabs by clicking on the tab name Home Assessments
40. eigh Total Population AS CEREALS AND CEREALS PROI Mean 0 mg kg b 0 0 0 0 0 2258 Irish NTFS 200 E110 Per unit body weigh Total Population Al BREADS AND BAKERY WARES Mean 0 003883 mg kg b 0 000126992 0 00367309 0 00408142 00035129 0 00416311 2346 Irish NTFS 200 E110 Per unit body weigh Total Population AB MEAT AND MEAT PRODUCT Mean 0 mg kg b 0 0 0 0 0 2434 Irish NTFS 200 E110 Per unit body weigh Total Population A9 FISH AND FISH PRODUCTS h Mean 0 mg kg b 0 0 0 0 0 2522 Insh NTFS 200 E110 Per unit body weigh Total Population A10 EGGS AND EGGS PRODUCTS Mean 0 mg kg b 0 0 0 0 0 0 ma ka b 0 0 0 0 0 2610 Irish NTFS 200 E110 Per unit body weiah Total Population All SWEETENERS AND HONEY Mean 4 m Figure 10 Results viewer Pie Chart and Data Distribution There are two types of distribution charts which can be selected from the statistic column in the data grid o PDF Probability density function which describes the relative likelihood for a random variable to occur at a given point note that in cases when there is a constant amount of exposure for all subjects the range of the PDF will be O to 1e 06 purely for graphing purposes FACET Internal Document Copyright O Creme Software Ltd 14 o CDF Cumulative distribution function which displays the probability that an exposure value will be found at a value less than or equal to a given number File Changes New Help Y L by w amp 3 A Ho
41. ere you specify the type and construction of each component of the packaging being used The layer of material used for the coating of the component can be selected from the list on the left hand side which also has a search box at the top Only the food contact layer is required To build up the structure FACET Internal Document Copyright O Creme Software Ltd 79 Add Layers w Select Packaging Wizard Search w Select Substance Material Code Description de specify Coating Ei M16 Pvc Select Food Categories M161 Plasticized PVC E ARO M 16 2 Non plasticizes Type Component not present M 17 PWC film res E M 21 Printing ink E M 21 1 Solvent based i E M2111 Flexo ink El M 21 1 PVB based flexo El M 2 PVB flexo Alu f PVB flexo Alu f M 2 PVB flexo OPP PVB flexo OPP PVB flexo OPP M 2 PVB flexo Pape PVB flexo Pape M 2 PVB flexo PE Include set off Surface Volume 0 00 Figure 94 Specify layers search by name 1 Atthetop there are three tabs Use these to select whether the component is a main closure or outer component 2 Select the component type from the Type drop down menu Main Closure Outer Type Component not present e Component not present Aerosol can Aluminium Container Tray Beverage Lan Food Can Metal Collapsible Tube Metal Other Figure 95 Select component type FACET Internal Document Co
42. from the drop down menu selected by default FACET Internal Document Copyright O Creme Software Ltd 71 Add Layers Include set off N Surface Volume 0 00 cm g Type Component not present j Lz Component not present Flexible Wrapper Bag Pouch Carton Case Beverage Milk Carton Glass Bottle Jar Plastic Bottle Jar Paper Board Based Tub or Tube Plastic Tray Pot Tub Cup Other Rigid Plastic Other Packaging Paper based Tray Gable top beverage carton Glass Bottle Brick shaped beverage carton Plastic Bottle EA Figure 83 Select component type 5 Add a material to the structure by selecting it from the list on the left and clicking on the blue arrow to add it to the structure Add Layers w Select Packaging Wizard Search Main he eos esa Select Substance Material Code Description toes Include set off F Specify Layers M 2 Metal Select Food Categories M3 Surface Volume 0 60 cm Paper Board H j Table Options MA RCF Type Blister Strip s M 5 Other non plas El M6 PE M7 EVOH Number Code Concentration mg kg Thickness microns 0 gt Food 1 M6 PE 112 M3 lonomer M9 OPP unspecified Other PP M 34 Adhesive Polyamide OPET Other PET P OPET PS PVC PVdC film res PLA and other Printing ink Figure 84 Add a
43. g micro sweets Fl A535 Strongly flavoured freshening throat pastilles m Fl an PICIE ARIS FICLIMNAMIICTC RAMOS CMIICTACCARIC ANN CATANA Select Surveys Assessment Options Assessment Summary 0 visible food categories selected 0 food categories selected Figure 28 Results returned by each key stroke FACET Internal Document Copyright O Creme Software Ltd 31 Select Food Categories w Select Assessment Type Search eet w Select Additive El Select All Select Food Categories Code Category Name FRUITS NUTS AND SEEDS E A3 2 Processed fruit E A3 2 4 Canned and bottled fruit Y A3 2 4 2 Sweet sour preserves of fruit E Fl A4 VEGETABLES STARCHY ROOTS LEGUMES AND SEAWEEDS E F A4 2 Processed vegetables E E A424 Canned or bottled or retort pouch vegetables E A 4 2 4 4 Sweet sour preserves of vegetables a E A4 2 6 Cooked or fried vegetables F A4 2 6 1 Vacuum packed sweetcorn E Fl AS CHOCOLATE PRODUCTS AND CONFECTIONERY E Fl A 5 3 Chewing gum and microsweets F A531 Chewing gum with added sugars Select Surveys Assessment Options Assessment Summary m A 5 3 2 Chewing gum without added sugars E A 5 3 3 Breath freshening microsweets in the form of films FJ A534 Other breath freshening micro sweets FJ A 5 3 5 Strongly flavoured freshening throat pastilles m an OPCI ARIS MCL NN ANIICTOC RAM IICA COLICTACFARIC ARKIN CA TANDAS 4 visible food categories selected 4 food categories selec
44. ges to the table are saved automatically FACET Internal Document Copyright Creme Software Ltd 62 Figure 69 Inserting a new row Delete Row 1 First open the table editor by double clicking on the table of interest or selecting the table and clicking on the Open button from the file menu or pressing Ctrl O 2 To delete single or multiple rows first highlight the required rows by clicking on the left hand margin of the relevant rows FACET Internal Document Copyright O Creme Software Ltd 63 File Changes New EE Sf Additrve Na 4 Concentration mg kg 4 Presence Probability DAIRY PRODUCTS AND AK E110 sunset yellow FCF DAIRY PRODUCTS AND AR E110 Sunset yellow FCF DAIRY PRODUCTS AND AR E110 sunset yellow FCF DAIRY PRODUCTS AND AR E110 Sunset yellow FCF Figure 70 Selecting and deleting multiple rows 3 Multiple rows can be selected by clicking and pressing the Ctrl key 4 To delete the selected rows click on the Delete Row icon or select Delete Rows from the Changes menu Delete Row s Figure 71 Delete rows 5 Changes to the table are saved automatically Entering data User defined concentration data requires the four types of information concentrations
45. ield takes a combination of numbers and letters Units are listed in mg kg bw unless otherwise specified e SCF EFSA Evaluation Numerical field showing the evaluation date Entries are in a four digit year type format e g 1991 Additive Ingredient Distributions This folder contains distributions of MPL concentration values for different combinations of food categories and flag settings The distributions are used to account for the fact that an additive MPL may be set for a component of a food e g in a topping These distributions are reference in the MPL database FACET Internal Document Copyright Creme Software Ltd 54 EAFET a FACE File Go New Help gt 4 Home E Assessments ___ FACET Data ES FACET Data 55 Flags E Food Categories Migration Information S Substances E ES Additives E Additive Info Additive Ingredient Distributio Flavourings 3 Packaging Surveys Name J Distribution BC1 d Distribution BC10 C Distribution BC11 E Distribution BC12 J Distribution BC13 J Distribution BC14 J Distribution BC15 LEH Distribution BC16 Figure 57 Additive Ingredient Distribution Packaging 4 Date Accessed 6 Dec 2013 09 45 6 Dec 2013 09 45 6 Dec 2013 09 45 6 Dec 2013 09 45 6 Dec 2013 09 45 6 Dec 2013 09 45 6 Dec 2013 09 45 6 Dec 2013 09 45 4 Date Created 4 Dec 2013 18 53 4 Dec 2013 18 54 4 Dec 2013 18 54 4 Dec 2013 18 54 4 Dec 2013 18 54 4 Dec 2013 18 54 4
46. is strictly a numeric field but can be any length e JECFA Number Joint FAO WHO Expert Committee on Food Additives This is strictly a numeric field but can be any length Additives The available search fields for substances assessed as additives are E Number and Name s Instant searching is enabled in both fields That is as you enter search criteria into the search box search results are returned at each key stroke A new search can be performed by either deleting what is in the search box or clicking on the Clear Search button The displayed table also indicates whether or not an MPL value is available for that additive FACET Internal Document Copyright Creme Software Ltd 23 Select Additive w Select Assessment Type Use pre installed FACET data Select Additive Search E Number Clear Select Food Categories Select Surveys E Numbe Additive Name Has MPL value aes E100 Curcumin MPL available 7 E101 Riboflavins MPL available D E102 Tartrazine MPL available 3 E104 Quinoline yellow MPL available 3 E110 Sunset yellow FCF MPL available E1102 imvertarc Ma RADI sieailshle Assessment Options Assessment Summary No substances selected D Use my concentration data Select Concentration Table 4 Name 4 Date Created 1 Date Accessed ES My Additive Data My Flavouring Data My Migration Data My Packaging Data Previous Figure 20 Available search fields fo
47. ised buttermilk unfl E627 Sterilised buttermilk unfl E628 Sterilised buttermilk unfl E629 Sterilised buttermilk unfl E630 Sterilised buttermilk unfll E631 Sterilised buttermilk unfl 632 Sterilised buttermilk unfll E633 m Figure 54 Additive MPL Table Figure 55 Restore Default Icon Eu Code Phosphoric acid Potassium phosphates Calcium phosphates Magnesium phosphates Diphosphates Polyphosphates Sodium phosphates Triphosphates Sodium citrates Konjac gum and Fu Glutamic acid Monosodium glutamate Monopotassium FEA Calcium diglutamate Monoammonium FERA Magnesium diglutamate Guanylic acid Disodium guanylate Dipotassium guanylate Calcium guanylate Inosinic acid Disodium inosinate Dipotassium inosinate Calcium inosinate Additives MPL Additive Name 4 Default Maxim 4 Maximum Perm 4 1000 0 1000 0 1000 0 1000 0 1000 0 1000 0 1000 0 1000 0 4000 0 1000 1000 1000 1000 1000 1000 Additives Occurrence Probabilities Database of occurrence probabilities of for FACET food categories Additives The Additives table contains information on all the different additives in FACET Clicking on the table once will bring up a preview in the bottom right pane showing a search box for browsing different fields The table contains the following fields FACET Internal Do
48. itted 8 Aug 2012 12 35 Software Version 1 7b2 Figure 4 Details of assessment e ID This is a unique identifier of the assessment within the program e Name The name given to the assessment by the user e Description Any further description the user included in the assessment FACET Internal Document Copyright Creme Software Ltd 9 e Type The type of the assessment Additive Flavouring or Packaging Migrant e Substance The substance used in the assessment e Survey s The survey s used in the assessment the number of subjects in the original survey Filtered Population Size and the number of subjects simulated Simulated Population Size e Population Filters Any population filters that may have been used in the assessment e Date Submitted The date on which the assessment was performed e Software Version The version of the software used to perform the assessment Organising Assessments To navigate about the assessment manager you can either 1 Use the Back Forward and Up buttons in the tool bar 2 Click on the folder whose contents you want to view in the folder tree in the left panel The subfolders contained in a folder can be viewed by clicking on the plus symbol next to a folder in the left hand pane 3 Double clicking on the folder or assessment you want to view in the top right pane The folder structure in the left hand panel will expand or collapse to show where in the asse
49. lain 1 Buttermilk plain 1 Dairy based drinks flawor 1 1 2 3 4 5 Condensed milk 3 Milk analogues 1 Soy and other vegetable 1 Beverage whiteners 1 me oj A Other milk analogues 1 Cream plain and the like 1 Cream plain ee 1 Cream analogues chu 1 Milk powder and cream A T Dried milk and dried PE T J d J elel Ra Re er al rl au RRA Milkpowder for vending r 7 T Figure 49 Conversion Factors Table Li L Figure 50 Restore Default Icon FACET Internal Document Copyright O Creme Software Ltd 50 Screening Calculations This folders contains tables of screening calculations for the different databases namely the APET SPET TAMDI and mTAMDI methods FACET Data El E FACET Data E5 Flags E5 Food Categories E Migration Information SS Substances E Additives E E flavourings E Flavouring Info SS Screening Calculations Packaging Surveys Name 3 Screening Calculations CoE 3 Screening Calculations IOFI Jecfa 2010 2 Screening Calculations DGSanco 3 Screening Calculations IOFI Jecfa 2007 5 Screening Calculations Young 2 Screening Calculations IOFI Jecfa 2006 2 Screening Calculations EFFA 2 Screening Calculations FEMA Figure 51 Screening Calculations Folder Additives The additive folder contains two subfolders Additive Info and Additive Ingredient Distributions lt FACET File Go New Help G E FACET Da
50. lick on the wizard icon in the tool bar and select New Assessment or select Create New Assessment in the home tab When selected the Assessment Wizard appears in a new window File New Help A V New Assessment 2 New Packaging Wizard New Table a H oD Figure 16 New assessment FACET Internal Document Copyright Creme Software Ltd 19 gt New Assessment e 2 New Packaging Wizard New Table Figure 17 New assessment 2 Depending on the assessment type there are eight or nine steps to complete 1 Select Assessment Type Choose the type of assessment flavouring additive or packaging migrant 2 Select Flavouring Additive Substance Choose substance to which exposure is to be estimated This step also allows you to choose between using pre installed FACET data or user specified concentration data 3 Select Concentration Data For a flavourings assessment this also allows the user to choose which of the pre installed sources of concentration to use 4 Select Pack Types For packaging assessments only Choose all or specific packaging types to use in an assessment 5 Select Food Categories Choose all or specific food categories 6 Select Surveys Choose between different consumption surveys and specific ages or genders 7 Assessment Options Choose assessment name description output statistics and other options for the assessment 8 Assessment Summary Summary of selections for this as
51. ll Select Pack Types Code Category Name E R Main Select Surveys seca Metal Can Assessment Options j Beverage Can Assessment Summa E a Food Can Aerosol can Select Food Categories 5 visible pack types selected 28 pack types selected Figure 24 Searching for and selecting pack types Food Categories Here you can select all food categories or specify which food categories you want to perform the assessment with FACET Internal Document Copyright O Creme Software Ltd 28 Select Food Categories w Select Assessment Type Search w Select Additive F Select All Select Food Categories Code Category Name El L A1 DAIRY PRODUCTS AND ANALOGUES A2 FATS AND OILS AND FAT EMULSIONS A3 FRUITS NUTS AND SEEDS A4 VEGETABLES STARCHY ROOTS LEGUMES AND SEAWEEDS A5 CHOCOLATE PRODUCTS AND CONFECTIONERY A6 CEREALS AND CEREALS PRODUCTS A7 BREADS AND BAKERY WARES A8 MEAT AND MEAT PRODUCTS A9 FISH AND FISH PRODUCTS MOLLUSCS CRUSTACEANS AND ECHINODERMS A10 EGGS AND EGGS PRODUCTS SWEETENERS AND HONEY SALT SPICES SAUCES AND SOUPS NUTRITIONAL FOODSTUFFS NON ALCOHOLIC BEVERAGES EXCEPT DAIRY BEVERAGES 5 Al COHOLIC REVFRAGFS Select Surveys Assessment Options Lt Assessment Summary E H 8 FHP FH FH E aaa 2 2 n n42 900000 ed H e E Figure 25 Select Food Categories By default no food categories are selected at this step For all substances you will be able to explore the relevant fo
52. m right pane 3 Click on the View All Results button in the top right hand side of the preview pane if available This will bring up the results viewer showing all statistics generated by the assessment at all food groups The results are outputted as a table that can be filtered as desired Any result can be viewed simultaneously so all fields have checkbox type filters Each filter type is described in detail below e Survey Used to alternate between different dietary surveys in a an exposure assessment e Substance Food Used to alternate between displaying exposure to a substance or intake of food e Intake Type The type of exposure which can be Absolute measured in mg per day or Per unit body weight measured in mg per kilogram of bodyweight per day e Consumer Type There are two possible consumer types Food Consumers and Total Population e FACET Food Code This allows you to decide which FACET food categories are displayed by their numerical food code e FACET Food Name This allows you to decide which FACET food categories are displayed by their food description e Statistic Shows what population statistic is plotted e g mean P90 P95 etc Running an Assessment The New Assessment Wizard provides the workflow to set up a new exposure assessment This can be selected from the file menu by selecting the New menu and then clicking on New Assessment Alternatively you can c
53. material and specify concentration of additive thickness of each layer FACET Internal Document Copyright O Creme Software Ltd 72 6 Specify the concentration of the additive in each layer in mg kg and the thickness of each layer in microns This value can also be a parametric distribution 7 Repeat for all required materials and components 8 The order of the layers can be re arranged by using the black up and down arrows next to each material 9 Materials can also be removed by clicking on the red minus symbol next to each layer Main Closure Outer Insert Include set off Surface Volume 0 60 lt cm g Type Blister Strip ES Number Code Name Concentration mg kg Thickness microns 0 Food 1 M6 PE 12 1 ME 2 M34 Adhesive 0 3 _ 3 MA Printing ink 0 1 ea 4 M3 OPET 0 2 Figure 85 Use arrows to re arrange layers and red minus to remove 3 Select Food Categories This is where you select the foods used for the assessment and the times and temperatures the packaging is in contact with the food Up to five time and temperature regimes can be selected 1 The foods used for the assessment can be selected from the list which has a search box at the top Once a food is selected click on the Create button This will open a new panel on the left hand side FACET Internal Document Copyright Creme Software Ltd 73 Add Food Categories w Select Packaging Wizard Search meat w Selec
54. me E Assessments FACET Data 02 My Data Results 110in E110 Per unit body weight Total Population CDF E110 Per unit body weight Food Consumers CDF 0 0 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 Chemical Exposure Chemical Exposure Y Survey VW Additive Food V Intake Type 4 Y Consumer T Y FACET Category Co 4 Y FACET Category Na 4 WY Statistic 4 Value 4 Units Standard Error 4 90 Cl Lower 90 Cl Upper 4 99 Cllower 4 99 Cl Upper 4 65 UK NDNS 1997 E110 Per unit body weigh Total Population A1 DAIRY PRODUCTS AND ANAI CDF Distributi mg kg b 87 UK NDNS 1997 110 Per unit body weigh Food Consumers A1 DAIRY PRODUCTS AND ANAI CDF Distributi mg kg b 153 UKNDNS 1997 110 Per unit body weigh Total Population A2 FATS AND OILS AND FAT EM CDF Distributi mg kg b 175 UK NDNS 1997 110 Per unit body weigh Food Consumers A2 FATS AND OILS AND FAT EM CDF Distributi mg kg b Figure 11 Results viewer Line Graph and Data To control what data appears on a selected graph there are filters in the headers of each column Clicking on the header shows the available filters for that field There are two filter types Y Survey 4 Y Additive Food 4 V Intake Type Y ConsumerT Y FACET Category Co 4 W FACET Category Na Y Statistic Value 4 Units 4 Standard Error 4 1730 Irish NTFS 200 E110 Per unit body weigh Total Population Al DAIRY PRODUCTS AND ANAI Mean 0 mg kg bw 0 1818 Irish NTFS 200
55. n Mean E110 Per unit body weight Food Consumers Mean 0 12 0 12 0 11 0 11 0 1 0 1 0 09 0 09 0 08 0 08 5 5 0 07 0 07 2 2 g 0 06 g 0 06 3 3 g 0 05 0 05 Vv v lt is O O 0 04 0 04 0 03 0 03 0 02 0 02 0 01 0 01 9 Al A 2 A3 AA AS AG A7 A8 AS A10 A 11 A 12 A 13 A14 A 15 A16 A 17 A 18 9 Al A 2 A 3 A4 AS A 6 A7 A8 AS A10 A11 A 12 4 13 A14 A 15 FACET Category FACET Category Y Survey Y Additive Food 4 W Intake Type Y Consumer T 4 Y FACET Category Co 1 W FACET Category Na 4 Y Statistic 4 Value 4 Units Standard Error 4 90 ClLower 4 90 CI Upper 1 99 ClLower 1 99 Cl Upper 58 UKNDNS1997 110 Per unit body weigh Total Population a Select All JCTS AND ANAI Mean 0 mg kg b 0 0 0 0 0 80 UK NDNS 1997 110 Per unit body weigh Food Consumers Y Al JCTS AND ANAI Mean 0 mg kg b 0 0 0 0 0 146 UK NDNS 1997 E110 Per unit body weigh Total Population Y A2 LS AND FAT EM Mean 0 mg kg b 0 0 0 0 0 168 UK NDNS 1997 110 Per unit body weigh Food Consumers J A3 LS AND FAT EM Mean 0 mg kg b 0 0 0 0 0 234 UK NDNS 1997 110 Per unit body weigh Total Population Y AA AND SEEDS Mean 0 000116 mg kg b 4 67861e 005 4 61191e 005 0 00019349 7 05279e 006 0 000254955 Y AS 256 UK NDNS 1997 110 Per unit body weigh Food Consumers AND SEEDS Mean 0 000128 mg kg b 4 73249e 005 5 45907 e 005 0 00020587 1 77053e 005 0 00024334 J AS 322 UK NDNS 1997 E110 Per unit body
56. n be entered by the FACET food code or the FACET food description To select a FACET food code 1 Double click on the cell with the either the header FACET Code or FACET Description or click on the cell and press return 2 Select the food category you want Entries with an arrow show the categories at the lower tier 3 Depending on which is selected the FACET Code and FACET Description will update automatically 4 Changes to the table are saved automatically FACET Internal Document Copyright O Creme Software Ltd 65 lt racer File Changes Ip F New He A J H gt amp 3 2 w n Y FACETC Y FACET Description 4 Y EuCo lt 4 Al DUCTS AND AN E110 b A nies gt A11 k paa Al2 AA b FA A112 gt a lata gt e ae A113 gt 3 A15 1 z Al6 j a8 b j as gt A10 h _ an gt Paz gt A13 gt Ald Figure 74 Facet food code hierarchy Flag Settings FACET flag settings can be entered by their number or description To enter a flag setting at a given setting 1 Double click on the cell for the flag you want to set using the flag description or number or click on the cell and press return 2 The list of available options for that cell will appear Select the one you want Double click on the cell you want to enter data into 4 Changes to the table are saved automatically Y Flagl
57. n meat substitutes E P 18 Composite foods El P18 5 Ready Meals Frozen processed red meat amp poultry Meat pies and quiches Figure 98 Create food category FACET Internal Document Copyright O Creme Software Ltd 82 4 Table Options This step presents you with a summary of the current choices of substances populations and food categories for the assessment After reviewing the choices you can choose to start an assessment using the Submit button at the bottom right of the window Equally you may wish to make changes to the selections Navigation to the appropriate steps to do this is easily achieved with the buttons on the left of the tab Table Options w Select Packaging Wizard Output file Data My Data My Migration Data New Migration Data Table w Select Substance W Specify Coating Packagi NewMetalPackT w Select Food Categories A mine Substance type Existing Substance Jable Spears Substance code 1334 Substance name Styrene Layers Component Type Layers Main Aerosol can 1 Food categories Food Code Description P 8 Meat and meat products Figure 99 Table Options FACET Internal Document Copyright O Creme Software Ltd 83 ES My Additive Data E My Flavouring Data My Packaging Data Filename Custom Migration Tablel Create Folder Figure 100 Saving custom migration to a file FACET Internal Document Copyright O Creme Software Ltd 84 Known Issues FACET 2 0 6 is p
58. nts of composite foods F9 Fish and fish products molluscs crustaceans and echinoderms including ingr F10 Eggs and egg products including ingredients of composite foods F11 Sweeteners and honey including ingredients of composite foods paa Salt spices herbs industrial sauces and soups including ingredients of compo Lm c12 Ri beitinm sl Enndeti ffe im rlicdim m imesendinmbr af ramon nite fnn nle i Figure 43 Example of category tree Migration Information This folder contains all material codes and pack types used in FACET File Go New Help a gt ES FACET Data E ES FACET Data Name 1 Row Count 1 Date Accessed 4 Date Created ES Flags H Material Hierarchy 9 Aug 2012 15 07 7 Aug 2012 14 47 ES Food Categories H Pack Type Hierarchy 9 Aug 2012 15 07 7 Aug 2012 14 47 Migration Information El ES Substances E Additives ES Flavourings SS Packaging S Surveys Template Tables Figure 44 Material Code folder The fields in the Material Hierarchy table are FACET Internal Document Copyright O Creme Software Ltd 46 e Material Code e Material Name r FACET A on o j De e oo uu File Go New Help H eo Home l Perens 5 FACET Data My Data El ES FACET Data Name 4 Date Accessed 4 Date Created 4 E Flags Pack Type Hierarchy 17 Aug 2012 17 01 7 Aug 2012 14 47 amp Food Categories 3 Material Hierarchy 17 Aug 2012 17 01 7 Aug 2012 14 4
59. od groups which are divided into 18 top level categories The letter at the beginning of each food category indicates the type of substance being assessed A for Additive F for Flavouring P for Packaging Migrant You can select deselect all categories by clicking on the Select All checkbox at the top right hand corner of the view To move to a lower tier of a particular food category simply click on the plus to the left of that category If there are further tiers within that category you can click on these to expand them further F Select All Code Category Name E A DAIRY PRODUCTS AND ANALOGUES 5 E A11 Milk and dairy based drinks A1 2 Condensed milk and milk analogues E A13 Cream plain and the like E A1 4 Milk powder and cream powder plain F A1 5 Cheese and analogues A1 6 Human milk to breast feed babies Figure 26 Select all box and expanded tier FACET Internal Document Copyright O Creme Software Ltd 29 Code Category Name A H Al DAIRY PRODUCTS AND ANALOGUES a A 1 1 Milk and dairy based drinks A1 1 1 Milk plain E FP A11 2 Buttermilk plain A 1 1 3 Dairy based drinks 3 A A1 2 Condensed milk and milk analogues F A 1 3 Cream plain and the like F A 1 4 Milk powder and cream powder plain Figure 27 Further expanded tier and example of tri state check box When a tier is selected all entries in that tier below are autom
60. of data tables that can be selected and viewed and left hand pane shows a tree structure that shows how the FACET folders are organised The bottom pane displays the contents of certain tables in the upper pane There are six main folders e Flags e Food Categories e Migration Information e Substances e Surveys FACET Internal Document Copyright O Creme Software Ltd 42 Clicking on the plus symbol next to each folder in the folder tree causes the contents of the tree to expand Each folder is described in detail below G Home Assessments la 5 FACET Data Flags Food Categories Migration Information E Substances ES Additives E Flavourings E Packaging F E Surveys Figure 40 Expanding folders using the plus symbol Flags This folder contains tables of the different possible flags used in the consumption diaries and chemical concentration tables Flags with the same meaning and settings are grouped in the same tables Both the numerical value and the text description of the flag settings are given in each table Food Categories This folder provides a list of all food categories in FACET The food categories are hierarchical and there is a separate system for flavourings additives and packaging There are three systems e Additives Food Hierarchy e Flavourings Food Hierarchy e Packaging Food Hierarchy FACET Internal Document Copyright O Creme Software Ltd 43 File Go New Help
61. ood item Figure 61 Visible fields in survey 14 Date Created 7 Aug 2012 14 18 7 Aug 2012 14 27 7 Aug 2012 14 23 7 Aug 2012 14 20 Copyright O Creme Software Ltd 58 My Data The My Data tab is where you can create view and edit your own data that can be used in exposure assessments You can organise your data in a similar fashion to any file manager e g Windows Explorer File Edit Go New Help XK S 4 rA Home gt Assessments Ea FACET Data E My Data Name 4 Progress 4 Type 1 Row Count amp My Additive Data My Flavouring Data Folder ES My Flavouring Data E My Additive Data Folder amp My Migration Data My Packaging Data Folder E My Packaging Data E My Migration Data Folder Figure 62 My Data Tab Managing Data Navigating about the data manager The My Data Tab is implemented in a two pane layout In the left hand pane is the folder tree which shows the hierarchy of your folders The right hand pane displays the contents of the current folder To navigate about the data manager you can either 1 Use the Back Forward and Up buttons in the tool bar 2 Click on the folder whose contents you want to view in the folder tree in the left panel The folder structure in the left hand panel will expand or collapse to show where in the file manager you are currently viewing gt 7 File Go New Help lx gt 4 G Home gt Assessments E FACET Data F My
62. opyright O Creme Software Ltd 38 Assessment Options w Select Assessment Type Assessment location Assessments My Assessments New Assessment X Select Migrant w Select Pack Types w Select Food Categories Description w Select Surveys l Assessment Options Consumer Loyalty Assessment Summary Assess using With consumer loyalty Without consumer loyalty Use SetOff Exclude homegrown homemade foods F Exclude restaurant canteen foods E 4 Advanced Options Figure 37 Assessment Options Advanced Options If the Show Advanced Options option is clicked you are presented with additional options relating to the statistics of the assessment H Advanced Options Include lowest tier results F w Minimum simulated population size 1001 111 Exposure statistics Mean Standard Deviation 7 Minimum 4 Maximum P25 P50 E P75 J P90 P95 P97 5 P99 P999 Other percentiles Figure 38 Advanced Options These are e Include lowest tier results Include output for all food categories at the lowest tier Note that this causes the assessment to take much longer to run FACET Internal Document Copyright O Creme Software Ltd 39 e Minimum simulated Population Size This is a numeric field allows the user to change the size of the population used in the simulation The number specified is the minimum population size used in the assessment the actual number used will be increased to
63. presents you with a summary of the current choices of substances populations and food categories for the assessment After reviewing the choices you can choose to start an assessment using the Submit button at the bottom right of the window Equally you may wish to make changes to the selections Navigation to the appropriate steps to do this is easily achieved with the buttons on the left of the tab FACET Internal Document Copyright Creme Software Ltd 75 Table Options w Select Packaging Wizard Output file Data My Data My Migration Data New Migration Data Table w Select Substance w Specify Layers w Select Food Categories Packaging type NewPackType Substance type Existing Substance TARIS HRUNS Substance code 1334 Substance name Styrene Layers Component Type Layers Main Blister Strip 4 Food categories Food Code Description P 9 Fish and fish products molluscs crustaceans and echinoderms Figure 89 Table Options E My Additive Data Z My Flavouring Data My Packaging Data Figure 90 Saving custom migration to a file FACET Internal Document Copyright O Creme Software Ltd 76 Metal Pack Type Select Packaging Wizard Select Packaging Wizard Select Substance Specify Coating Select Food Categories Table Options New Pack Type New Metal Pack Type Figure 91 New metal pack type assessment The new metal structure feature assesses the impa
64. provided to FACET FACET Internal Document Copyright Creme Software Ltd 26 Each dataset has a set of warnings associated with it that the user should consider before preforming an exposure assessment with that particular dataset Select Concentration Data w Select Assessment Type Council of Europe 2000 IOFI 2006 use levels provided to JECFA w Select Flavouring EFFA use levels provided to EFSA IOFI 2007 use levels provided to JECFA FEMA reported in Fenaroli s Handbook 2005 IOFI 2007 use levels provided to DG SANCO Young et al 2006 IOFI 2010 use levels provided to FACET Select Concentration Data Select Food Categories Select Surveys Warning Assessment Options The use levels provided in this database have been extracted from Fenaroli s handbook of flavor ingredients Burdock G A 2005 5th ed Boca Raton Florida CRC Press Usual and maximum use levels are reported for 1581 flavourings in 34 food categories reported by the Flavor and Extract Manufacturers Association of the United States FEMA Assessment Summary Note Data relate to use levels for North America and may not be indicative of actual use levels in Europe for all materials listed All data were reported prior to the year 2001 ranging as far back as 1994 for some materials and may not represent current use levels for the listed materials Cancel Previous 1 Figure 23 Selecting the source of concentration data Select Pack Type
65. pyright Creme Software Ltd 80 3 Add a material to the structure by selecting it from the list and clicking on the blue arrow to add the structure Search pv Material Code M 16 M 16 1 M 16 2 M 17 M 21 3 M 211 3 M 21 1 1 a M 211 M2 E M 2 3 M2 E M 2 Ge Description PVC Plasticized PVC Non plasticize PVdC film res Printing ink Solvent based i Flexo ink PVB based flexo PVB flexo Alu f PVB flexo Alu f PVB flexo OPP PVB flexo OPP PVB flexo OPP PVB flexo Pape PVB flexo Pape PVB flexo PE Main Closure Outer Include set off de Surface Volume 0 00 cm g e Type Aerosol can E Number Code Name Concentration mg kg Thickness microns 0 Food 1 M16 PVC gt Figure 96 Add a material and specify concentration of additive thickness of each layer 4 Specify the concentration of the additive in each layer in mg kg and the thickness of each layer in microns 3 Select Food Categories This is where you select the foods used for the assessment and the rate of extraction of the additive from the can coating 1 The foods used for the assessment can be selected from the list which has a search box at the top Once a food is selected click on the Create button This will open a new panel on the left hand side FACET Internal Document Copyright O Creme Software Ltd 81
66. r Additives e E Number This field takes a combination of numbers and letters e Name s This searches the additive name field Packaging Migrant Note that only substances that have been pre populated using the migration model will appear here The available search fields for substances assessed as packaging migrants are FACET ID CAS Number Name s Molecular Formula and Molecular Weight The CAS Number field has the same options as those available when searching for flavourings as described above Instant searching is enabled in all fields That is as you enter search criteria into the search box search results are returned at each key stroke A new search can be performed by either deleting what is in the search box or clicking on the Clear Search button e FACET ID This is strictly a four digit number with no leading zeros e g 1021 e CAS Number This is strictly of the form up to 7 digits 2 digits 1 digit e g 64 17 5 or 0000064 17 5 FACET Internal Document Copyright O Creme Software Ltd 24 e Name s This searches both the Chemical Name and Alternative Name fields e Molecular Formula This field takes a combination of letters and numbers e Molecular Weight This is strictly a number with up to a maximum of 3 decimal places e g 60 301 5 72 345 e Pre populated For each pre populated substance this field is set to WITHOUT WITH or BOTH The first option WITHOU
67. r the name of the additive in the box provided 2 Enter the Log P of the substance 3 Enter the molecular weight of the substance Existing Substance 1 Search for the name of the substance in the search box provided 2 Select the substance from the list FACET Internal Document Copyright Creme Software Ltd 69 9 Existing Substance Ce FACET Code CAS Number Chemical Mame Alternative Name Molecular Formula Molecular Weigh 1004 0061788 Acids fatty Fatty acids C C36H6804 564 a 1005 0068783 Acids Fatty Fatty acids C 1006 0000079 Acrylamide 2 propenamide C3H5N101 71 1007 0015214 2 Acrylamid 2 methyl 2 1 C7H13MN10451 1008 OO00079 Acrylic acid Polyacrylic Acid C3H402 1009 0002495 Acrylic acid Benzyl acrylate C10H10012 1010 0000141 Acrylic acid m Butyl aerylat C7H1202 1011 0002998 Acrylic acid sec Butyl met C7H1202 1012 0001663 Acrylic acid bert Butyl acry C7H1202 O O O O O O O 111 Mothing selected Figure 81 Search for existing substance and submit Once all the steps have been completed click the Submit button 2 Specify Layers This is where you specify the type and construction of each component of the packaging being used The layers of materials used for the construction of the component can be selected from the list on the left hand side which also has a search box at the top The order of the laye
68. rd icon and selecting New Table There are three steps to complete 1 Substance Type Select whether the table is for a new additive flavouring or packaging substance 2 Select Substance Select the substance that will be used for the assessment 3 Table Options Select the name and location of the table in the My Data tab File New Help Xx V New Assessment New Packaging Wizard OH __ FACET Data New Table Figure 65 New table wizard using new menu File New Help a i New Assessment ts FACET Data My Data New Packaging Wizard Es New Table facet Figure 66 New table wizard using assessment wizard icon The Data Editor You can edit your own data using the table editor in FACET To bring up the data editor double click on a table in the list view The available operations are listed below FACET Internal Document Copyright O Creme Software Ltd 61 Figure 67 Data Editor Insert Row 1 First open the table editor by double clicking on the table of interest or selecting the table and selecting Open from the file menu 2 To insert a new row into a table in the table editor select Insert row from the Changes menu or click on the Insert row icon File Changes New Help Xx F 2 Insert Row B Delete Rows Reset Sort 2 Sort Ascending Y Sort Descending Figure 68 Insert row using changes menu 3 Chan
69. redients of composite foods E F 6 Cereals and cereal products including ingredients of composite foods E F 7 Breads and bakery wares including ingredients of composite foods F 8 Meat and meat products including ingredients of composite foods Figure 42 Fields available in each table Each system can be viewed as a tree and clicking on the arrow in each category causes the contents of that category to be displayed which in turn can be expanded and so on You can also search the data using the search box that appears between the panes FACET Internal Document Copyright O Creme Software Ltd 45 FACET Data Search Code Category Name Dairy products and analogues including ingredients of composite foods a F2 Fats and oils and fat emulsions including ingredients of composite foods a F 2 1 Fats and oils essentially free from water F 2 1 1 Vegetable oils and fats F 2 1 2 Lard tallow fish oil and other animal fats F 2 2 Fat emulsions mainly of type water in oil S F3 Fruits nuts and seeds including ingredients of composite foods 1 F 4 Vegetables starchy roots legumes and seaweeds including ingredients of co ES Chocolate products and confectionery including ingredients of composite foo F6 Cereals and cereal products including ingredients of composite foods F 7 Breads and bakery wares including ingredients of composite foods FS Meat and meat products including ingredie
70. roject Summary In the centre of the page is a brief summary of the FACET project e Quick start buttons Below the project summary there are three quick start buttons These are o Create New Assessment This launches the FACET Assessment Wizard that guides you through the steps required to perform an assessment Clicking on this button is equivalent to clicking on the New Assessment button in the toolbar at the top of the screen o Goto FACET Data Clicking on this button will bring you to the FACET Data tab where you can browse through non confidential data built into the program Clicking on this button is equivalent to clicking on the FACET Data tab o Goto My Data Clicking on this button opens the My Data tab where you can browse and edit your own custom data for use in an assessment Clicking on this button is equivalent to clicking on the My Data tab File New Help Assessments 5 FACET Data My Data facet Flavourings Additives and Food Contact Materials Exposure Task FACET is a food chemical exposure surveillance system to meet the needs of EU regulatory authorities in the protection of consumer health European Commission 7th Framework Programme 2008 2012 F Create New Assessment B Go To FACET Data FF Go To My Data Figure 1 The Home Tab FACET Internal Document Copyright O Creme Software Ltd 7 Assessments The assessment tab is where all of your assessments can be
71. rototype software and some minor issues may still exist Please note that these issues will be eliminated in the final version of the software In particular the following issues have been recorded e Windows are known to freeze in certain cases If this happens follow the steps in the troubleshooting section on restarting the software e Opening and closing the same assessment repeatedly can cause FACET to crash Troubleshooting Every effort has been made to ensure that FACET 2 0 6 is stable and error free However as the software is a prototype some unforeseen issues may arise If the software stops working for some unknown reason it is recommended that the following procedures be followed in sequence Restart the software 1 Close the software by clicking on the X in the top right corner of the main FACET window or by selecting File and Exit If this fails to close the program proceed to the section called Close FACET using the Task Manager 2 If FACET closes successfully restart FACET by selecting Start gt All Programs gt FACET gt FACET 2 0 6 3 If the issue is still unresolved proceed to the section Close FACET using the Task Manager Close FACET using the Task Manager Press Ctrl Alt Delete on your keyboard Click on Start Task Manager Click on the Processes tab Inthe Image Name column click on any process that begins with FACET to highlight it e g FACET Datab
72. rs is built up from the food layer outwards To build up the structure FACET Internal Document Copyright O Creme Software Ltd 70 New Packaging Wizard w Select Packaging Wizard w Select Substance Search pyl Material Code El M16 M 16 1 M 16 2 M 17 E M 21 E M211 Ej M 21 1 1 Specify Layers Select Food Categories Table Options Clear Description 4 PVC Plasticized PVC Non plasticize PVAC film res Printing ink Solvent based i Flexo ink Add Layers Main Closure Outer Insert Include set off Surface Volume 0 00 Type Component not present Lz El M 21 1 E M 2 PVB based flexo PVB flexo Alu f PUB flexo Alu f PVB flexo OPP PVB flexo OPP PVB flexo OPP PUB flexo Pape PVB flexo Pape PVB flexo PE Figure 82 Specify layers search by name 1 Atthetop on the right hand side there are four tabs Use these to select whether the packaging has a main closure outer or insert component 2 The user has the option to select set off in the assessment This is achieved by checking the Include set off option 3 The surface to volume ratio can be specified by entering the appropriate value in cm2 g in the box to the right of Surface Volume 4 For each tab select the component type from the Type drop down menu If the structure doesn t have a particular component select Component not present
73. s If the substance of interest is a packaging migrant you can select all packaging types or specify which particular types to perform the assessment with If the substance is a flavouring or additive this step is skipped By default no pack types are selected for this step You can select deselect all packs by clicking on the checkbox at the top left hand corner of this step The pack types are arranged into four groups Main Closure Outer and Insert To view the contents of a particular pack type simply click on the plus symbol to the left of that pack type When pack category is selected all entries in the tier below are automatically selected too Tri state checkboxes are also enabled whereby a square is shown in the checkbox to indicate the box is neither checked nor unchecked This is the case when some but not all elements of a particular category are checked FACET Internal Document Copyright O Creme Software Ltd 27 Instant searching is enabled for the pack types That is as you enter search criteria into the search box search results are returned at each key stroke Sections that match the search are returned highlighted in yellow To search and select multiple pack types you can simply search select packs of interest and search again The pack types you selected will remain selected even if they are not displayed Select Pack Types w Select Assessment Type Search can w Select Migrant Y Select A
74. sessment and proceed to submit assessment You will be guided through these steps in sequential order On successful completion of each step you can proceed to the next step by clicking the Next button at the bottom left of the program window If you click the Next button without successfully completing the current step a red X will appear next to that step to indicate it has not been successfully completed You can also navigate between the already completed steps by either e Clicking Next at the bottom right of the program window e Clicking Previous that appears in the bottom right of the Assessment Wizard window e Clicking the stage name buttons at the left hand of the program window It is not possible to proceed to a later step using these stage name buttons without having already completed all steps previous to this later step FACET Internal Document Copyright O Creme Software Ltd 20 Select Assessment Type In Step 1 you are required to specify whether you are going to perform an assessment using a flavouring additive or packaging migrant You can select one of these three options by clicking on the appropriate image above the desired assessment type Select Assessment Type Select Assessment Type y y i Flavouring Assessment Additive Assessment Packaging Assessment Figure 18 Selecting an assessment type Select Substance The target substance for the assessment can be
75. sment 1 Navigate to where the assessment is located in the assessment manager and click on it 2 A summary of the assessment will appear in the bottom right pane 3 Click on the View Graphs button in the top right hand side of the preview pane This will bring up the results viewer showing graphs and statistics generated by the assessment FACET Internal Document Copyright O Creme Software Ltd 12 View All Results View Figure 8 View report buttons FACET File Changes New Help R C E ty Mv x Results E110 in O A Home E Assessments ea FACET Data My Data E110 Per unit body weight Total Population Mean E110 Per unit body weight Food Consumers Mean 0 19 0 19 0 18 0 18 0 17 0 17 0 16 0 16 0 15 0 15 0 14 0 14 9 13 0 13 3 3 0 12 0 12 0 11 E 0 11 0 1 5 0 1 8 0 09 2 0 09 H 0 08 S 0 08 2 0 07 0 07 0 06 0 06 0 05 0 05 0 04 0 04 0 03 0 03 0 02 0 02 0 01 0 01 o Al A2 A3 A4 CAS A6 A7 A 8 AD A10 A11 A12 A 13 A 14 A 15 A 16 A 17 A 18 All o A1 A2 A3 A4 A5 A6 A 7 A 8 AS A 10 A11 A 12 A 13 A 14 A 15 A 16 A 17 A 18 Al FACET Category FACET Category Y Survey 4 Y Additive Food 4 Y Intake Type Y ComsumerT 1 Y FACET Category Co 4 Y FACET Category Na 4 W Statistic 1 Value Units Standard Error 4 90 Cl Lower 4 90 Cl Upper 4 99 ClLower 4 99 Cl Upper 4 1730 irish NTFS 200 E110 Per uni
76. ssessments tab by clicking on the Choose button It is recommended that you choose a sufficiently descriptive name other than the default New Assessment In the Assessment description text box the user can enter additional details about their assessment Assessment Options w Select Assessment Type Assessment location Assessments My Assessments New Assessment 22 Choose w Select Additive E Description w Select Food Categories w Select Surveys Assessment Options Assessment Summary Figure 33 Basic view of assessment options You will also need to choose an output folder for your assessment by clicking on the Choose button This opens a pop up window giving you the option of selecting a destination folder By default all assessments are contained in the Assessments folder You can create a subfolder by clicking on the New Folder button at the bottom of the dialogue box and then entering a name for the new folder Alternatively right click on where you want to create the folder and select New Folder from the context menu FACET Internal Document Copyright O Creme Software Ltd 35 e Y Save A Ario a e E ES My Assessments sample Assessme Specify the name of the new folder Mew Folde Filename AdditiveAssessmentl 4 Create Folder Cancel a Figure 34 Choosing an output folder Flavouring Assessment Options Depending
77. ssment manager you are currently viewing File Edit Go New Help 1 49 4 G Home TO Assessments Figure 5 Back forward up arrows Creating a new folder 1 To create a new folder right click on where you want to create it in the top right pane and select Create Folder Alternatively select Create Folder from the file menu 2 This will bring up a dialogue box into which you can enter the name of the new folder 3 After entering the name of the new folder click on OK and the new folder will be created FACET Internal Document Copyright O Creme Software Ltd 10 4 ID 4 Date Created Name Progress Lal E110 in IRE UK teens Complete 592 16 Jul 2013 12 5 Create Folder h IH 4 Figure 6 Creating a new folder Renaming a folder 1 Torename a folder right click on the folder you want to rename and select Rename Alternatively you can select the folder and choose Rename from the Edit menu 2 This will bring up a dialogue box into which you can enter the new name of the folder Enter the new name of the folder into the dialogue box and click on Rename Deleting a Folder 1 To delete a folder right click on the folder you want to delete and select Delete from the context menu 2 Alternatively select the folder you want to delete and choose Delete from the Edit menu 4 ID 4 Date Created 592 16 Jul 2013 12 5 16 Jul 2013 13 2 Name 1
78. t Substance Food Code Description v Specify Layers P8 Meat and meat products Select Food Categories E P81 Fresh Meat Table Options a Fresh meat P8 2 Processed meat products Processed meat and meat products Coated battered meat and meat products Preserved meat and meat products Frozen Meat amp Meat Products Unprocessed frozen meat and meat products Frozen meat substitutes P18 Composite foods El P 18 5 Ready Meals Frozen processed red meat amp poultry Meat pies and quiches T one DO lu i Figure 86 Search for food category 2 P At the top of the new panel select the market share the component has in that food category by entering the appropriate value in the box Enter the volume of the pack the new component will be used with Enter the Pack size in grams In the bottom box enter the upper and lower limits of the times and temperatures the food component combination will undergo The units can be specified in the drop down menus on the right hand side Additional time temperature regimes can be added by clicking on the green plus symbol on the right hand side Time temperature regimes can be removed by clicking on the red minus symbol on the right hand side FACET Internal Document Copyright Creme Software Ltd 74 Add Food Categories w Select Packaging Wizard Search P 9 Fish and fish products molluscs crustaceans and echin Remove w Select Substance Food Code Des
79. t body weigh Total Population Al DAIRY PRODUCTS AND ANA Mean 0 mg kg b 0 0 0 0 0 1752 Irish NTFS 200 110 Per unit body weigh Food Consumers Al DAIRY PRODUCTS AND ANA Mean 0 mg kg b 0 0 0 0 0 1818 Irish NTFS 200 E110 Per unit body weigh Total Population A2 FATS AND OILS AND FAT EM Mean 0 mg kg b 0 0 0 0 0 1840 Irish NTFS 200 E110 Per unit body weigh Food Consumers A2 FATS AND OILS AND FAT EM Mean 0 mg kg b 0 0 0 0 0 1906 Irish NTFS 200 E110 Per unit body weigh Total Population A3 FRUITS NUTS AND SEEDS Mean 0 000357 mg kg b 9 60646e 005 0 0001919 0 000516376 0 000136364 0 000585495 1928 Irish NTFS 200 E110 Per unit body weigh Food Consumers A3 FRUITS NUTS AND SEEDS Mean 0 000415 mg kg b 0 000115633 0 000262993 0 000620854 0 000162812 0 000778137 1994 Irish NTFS 200 E110 Per unit body weigh Total Population AA VEGETABLES STARCHY ROO Mean 0 000938 mg kg b 0 000106893 0 000773855 0 00113439 0 000673949 0 00120146 2016 Irish NTFS 200 E110 Per unit body weigh Food Consumers AA VEGETABLES STARCHY ROO Mean 0 000938 mg kg b 0 000107052 0000756923 0 00112133 0000693662 0 0011945 2082 Irish NTFS 200 E110 Per unit body weigh Total Population AS CHOCOLATE PRODUCTS AN Mean 0 001111 mg kg b 6 54223e 005 0 00101086 0 00122193 0 000963456 0 0012763 2104 irish NTFS 200 E110 Per unit body weigh Food Consumers AS CHOCOLATE PRODUCTS AN Mean 0 001224t mg kg b 7 02029e 005 0 00111227 0 001329 0 00101243 0 0013905 2170 kish NTFS
80. ta 4 Date Accessed 20 Aug 2012 17 15 20 Aug 2012 17 15 20 Aug 2012 17 15 20 Aug 2012 17 15 20 Aug 2012 17 15 20 Aug 2012 17 15 20 Aug 2012 17 15 20 Aug 2012 17 15 No preview available for this file 4 Date Created 20 Aug 2012 15 16 20 Aug 2012 15 16 20 Aug 2012 15 16 20 Aug 2012 15 16 20 Aug 2012 15 15 20 Aug 2012 15 16 20 Aug 2012 15 15 20 Aug 2012 15 15 GB FACET Data Name Date Accessed Date Created _ C amp Flags E Additive Info 6 Dec 2013 09 41 4 Dec 2013 17 40 EA Food Categories E Additive Ingredient Distr 6 Dec 2013 09 41 4 Dec 2013 17 40 Migration Information E E Substances sa Addtrves E Additive Info E5 Additive Ingredient Distributio amp E Flavourings 9 Packaging ES Surveys Figure 52 Additive Folder FACET Internal Document Copyright O Creme Software Ltd 51 Additive Info The additive info folder contains three tables MAR AE File Go New Help iape PA Home Assessments FACET Data 5 My Data E E FACET Data Name 4 Date Accessed 4 Date Created 4 ES Flags Additives 6 Dec 2013 09 41 4 Dec 2013 18 52 Food Categories J Additives With Group Al 6 Dec 2013 09 41 4 Dec 2013 18 52 E Migration Information J Additives MPL 6 Dec 2013 09 41 4 Dec 2013 18 52 E Substances J Additive Occurence Prol 6 Dec 2013 09 41 4 Dec 2013 18 53 E ES Additives a Additive Info E Additive Ingredient Distributio E Flavourings Packaging E ES Sur
81. ted Figure 29 Searching for and selecting food categories Select Survey Here you have the option of using a specific food consumption surveys with which to perform your assessment To choose a survey simply click on your choice from the list and click on the Next button Note that some countries have more than one survey Multiple surveys can also be selected and all surveys can be selected for use in an assessment by clicking the Select All checkbox in the top left hand corner of the view Note that selecting all surveys for a particular assessment can take a long time to run FACET Internal Document Copyright Creme Software Ltd 32 as AS NEW ASS S SIT Select Surveys w Select Assessment Type Search w Select Additive H Select All w Select Food Categories a V e UK Hungary E l France Poland Finland ft Ireland R H Italy Fd Portugal Assessment Options Assessment Summary Gender Male Female Age years Between 0 2 and 110 3 Filtered Population Size 6963 Figure 30 Selecting a survey FACET Internal Document Copyright O Creme Software Ltd 33 w Select Assessment Type Search w Select Additive Select All w Select Food Categories 5 UK T UK NDNS 1992 1 4 V T UK NDNS 1997 4 18 E T UK NDNS 2000 19 64 E T UK NDNS 1995 Over 65 Hungary 88 France F em Poland E Finland u Ireland T Irish NCFS 200
82. the next multiple of the number of subjects chosen after the filtering in Step 7 e Exposure Statistics These are checkboxes that allow the user to include the following statistics in the assessment the first four options P90 and P97 5 are selected by default o Mean Standard Deviation Minimum Maximum P25 P50 P75 P90 P95 P97 5 P99 o P99 9 e Other Percentiles This is a numeric field Other percentiles can be entered separated by commas e g 92 93 e Confidence Intervals These are checkboxes that allow the user to specify the following confidence intervals the standard error is selected by default o Standard Error o 90 Confidence Interval o 95 Confidence Interval o 99 Confidence Interval e Other Confidence Intervals This is a numeric field Other confidence intervals can be entered separated by commas e g 75 85 e Use consumer loyalty For additives and flavourings a consumer loyalty model can be used as part of the exposure assessment This brings up a new Set of food categories to used in the consumer loyalty model e Truncate at SML value This only applies to packaging assessments If chosen an SML can be entered to truncate concentration values calculated by the migration model O 0 0 02 070 10 0 0 0 Assessment Summary This step presents you with a summary of the current choices of substances populations and food categories for the assessment FACET Internal Document Copyright O
83. u 100 0 A1 DAIRY PRODUCTS AND ANAI Mean 214 835 4 23178 Al DAIRY PRODUCTS AND ANAI Standard Deviatio 155 209 4 30623 Al DAIRY PRODUCTS AND ANAI Minimum 0 Al DAIRY PRODUCTS AND ANAI Maximum 871 588 g g g 0 209841 g Al DAIRY PRODUCTS AND ANAI P25 101 997 g 4 89288 g g g g 18 7314 Al DAIRY PRODUCTS AND ANAI P90 429 841 Al DAIRY PRODUCTS AND ANAI P97 5 617 781 Al DAIRY PRODUCTS AND ANAI CDF Distributi Al DAIRY PRODUCTS AND ANAI PDF Distributi Al DAIRY PRODUCTS AND ANAI Count 1206 Al DAIRY PRODUCTS AND ANAI Percentage Cons 100 Al DAIRY PRODUCTS AND ANAI Mean 0 A1 DAIRY PRODUCTS AND ANAI Standard Deano 0 13 4244 WW ois O in ja Wi Nn jr 21 4082 w a nls ulini Rrio Wt Figure 15 Data only view Viewing All Results Results can be viewed in all food categories at the lowest if this option is selected when the assessment is run see Running an Assessment for details If this option was checked when the assessment was run the button View All Results will be available If this option was not chosen when the user ran the assessment this option will be greyed out To view results generated by an assessment FACET Internal Document Copyright Creme Software Ltd 18 1 Navigate to where the assessment is located in the assessment manager and click on it 2 Asummary of the assessment will appear in the botto
84. vey Y Additive Food 4 Y Intake Type 4 Y ConsumerT 4 W FACET Category Co 4 Y FACET Category Na 1210 UK NDNS 1997 E110 Per unit body weigh Total Population A14 NON ALCOHOLIC BEVER 1232 UK NDNS 1997 E110 Per unit body weigh Food Consumers A 14 NON ALCOHOLIC BEVER _ Figure 14 Probability density function chart and data Viewing Data Only To see the raw data calculated in an exposure assessment click on the table icon in the toolbar This will bring up a data only view FACET Internal Document Copyright Creme Software Ltd 17 The table fields are the same as before when the different graphs are being shown However since all the data is no longer being plotted different combinations of data can be viewed simultaneously Thus all the filters are checkboxes when this view is selected The values displayed can be exported as a CSV Comma Separated Values file at any time by clicking on the export icon located in the top left hand corner of the data grid Data exported in CSV formatted can be opened later in a spreadsheet program like Microsoft Excel File Changes New Help 8 47 99 E wW Y a a Home Assessments a FACET Data My Data Results E110 in api 4 Y FACET Category Co 4 W FACET Category Na 4 W Statistic 4 Value Units 4 Standard Error 4 90 CI Lower Al DAIRY PRODUCTS AND ANAI Count 1206 0 Al DAIRY PRODUCTS AND ANAI Percentage Cons
85. veys Figure 53 Additive Info Folder Additives MPL A table of Maximum Permitted Levels MPLs for the FACET food categories and flag settings as well as the calculated probability of addition The MPL values in this table can be changed in order to assess the impact of varying the MPL values in an exposure assessment The field that can be edited is in white In order to restore the default MPLs click the Restore Default icon in the tool bar FACET Internal Document Copyright O Creme Software Ltd 52 File Changes New Help 1033 1 S 5 Home 5 Assessments l FACET Data Additives MPL Additive Tier1 4 FACET Code 4 A1111 A1111 A1111 A1111 A1111 A1111 A1111 A1111 A1113 A1122 A1122 A1122 A1122 A1122 A1122 A1122 A1122 A1122 A1122 A1122 A1122 A1122 A1122 A1122 mi Win wo orn O fas o FACET Descripti Sterilised and UHT milk Sterilised and UHT milk Sterilised and UHT milk E340 Sterilised and UHT milk E341 Sterilised and UHT milk E343 Sterilised and UHT milk E450 Sterilised and UHT milk E451 Sterilised and UHT milk E452 UHT goat milk E331 Sterilised buttermilk unfl E425 Sterilised buttermilk unfl E620 Sterilised buttermilk unfl E621 Sterilised buttermilk unfl E622 Sterilised buttermilk unfl E623 Sterilised buttermilk unfl E624 Sterilised buttermilk unfl E625 Sterilised buttermilk unfll E626 Steril
86. weigh Total Population J A7 STARCHY ROO Mean 0 000262 mg kg b 0 00011918 9 39394e 005 0 000453006 5 38889e 005 0 000694681 344 UK NDNS 1997 110 Per unit body weigh Food Consumers S STARCHY ROO Mean 0 000262 mg kg b 0 000124699 8 52475e 005 0 000486468 5 6948e 005 0 000628229 Figure 13 Column chart and data There are additional fields that are used to display values in the chart type These are e Value The value s of exposure being displayed and plotted according to the filter settings chosen e Units The units of the value being displayed FACET Internal Document Copyright Creme Software Ltd 16 e Standard Error and Confidence Intervals These are used to display any confidence intervals calculated for the assessment presented as upper and lower bounds In the case of the standard error this is a single value The values displayed can be exported as a CSV Comma Separated Values file at any time by clicking on the export data icon located in the toolbar ka Data exported in CSV formatted can be opened later in a spreadsheet program like Microsoft Excel lt FACET an File Changes New Help a lt amp E 32 ol g9 E110 Per unit body weight Food Consumers PDF 6 E110 Per unit body weight Total Population PDF Probability Distribution Probability Distribution 0 2 03 04 05 06 07 0 8 01 02 03 04 OS 06 07 0 8 Chemical Exposure E Chemical Exposure Y Sur

FACET Exposure Assessment Tool User Manual

Contents

Download Pdf Manuals

Related Search

Related Contents