Thermo Scientific HyPerforma Single
Contents
1. Front face Back face A 7 Powder addition port a S Tubing set inner diameter x outer diameter x length End treatment 1 Recirculation line 12 7mm 2 in x 19 1mm 9 in C Flex x 122cm 48 in splits to Capped 12 7mm 2 in MPX insert 12 7mm 2 in x 19 1mm 34 in C Flex x 61cm 24 in and Plugged 12 7mm 1 2 in MPX body 12 7mm in x 19 1mm 9 in C Flex x 30cm 12 in 2 Addition line 12 mm 2 in x 19 1mm 4 in C Flex x 122cm 48 in Plugged 12 7mm 1 2 in MPX insert 3 4 Probes ports 2 None Kleenpak aseptic connector KPCHT series female 5 Thermowell 3 2mm Ys in x 6 4mm in C Flex x 30cm 12 in Luer and SmartSite valve port small volume sample Bottom drain 12 7mm in x 19 1mm 34 in C Flex x 122cm 48 in Capped 12 7mm 2 in MPX body Powder addition port 76mm 3 in sanitary fitting tri clamp Cap with gasket Standard 50L BPC for liquid liquid applications with probe ports Impeller 1 2 Probe ports 2 Front face ms 3 Thermowell small volume sample 5 Recirculation line 6 Fill line 4 Bottom drain IE Back face j i 7 Vent filter Tubing set inner diameter x outer diameter x length End treatment 1 2 Probes ports 22. Description Cat No Mettler Toledo pH monitoring device single channel SV51004 01 Mettler Toledo pH monitoring device dual channel SV51004 02 Mettler Toledo pH and conductivity monitoring device dual channel SV51004 07 Threaded probe attachment Autoclave tray and probe assembly Cable ti The autoclave tray holds the electrochemical probes and bellows in place during the autoclave sterilization process Design elements include the following e Fabricated from stainless steel Molded Handle Nea 4 bellows cover e Plastic handle provides for easy transport right out of the autoclave e Positions probes on 15 P incline for greater probe and P dj Probe 7 748 membrane longevity assembly e Restrains probe bellows from collapsing during sterilization e Probe holder accommodates two probes Probe clips Stainless steel probe clips are used to hold the probes in place on the S U M tank The independently moveable probe clips hang on a thin brace above the probe port tank cutout and are held in place by an adjustable spring plunger The probes are inserted into the clio mechansim and held in place by a half spring clip Ordering information Autoclave tray 9V50177 01 4 probe clips SV oO 23 Heavy duty tubing clamps Heavy duty clamps are used for pinching off line sets that are not in use in order to prevent process fluids from escaping Prior to sterile probe insertion tubing clam
3. DATA SHEET SOL HyPerforma Single Use Mixer Thermo Scientific HyPerforma single Use Mixer The next generation of efficiency and performance The next generation Thermo Scientific HyPerforma Single Use Mixer S U M provides you with enhanced functionality ease of use and efficiency The complete HyPerforma S U M system consists of a mixer tank with a motor controller available in sizes of 50 100 200 500 1 000 and 2 000L with a 5 1 turndown mixing ratio The redesigned HyPerforma S U M maintains traditional stirred tank mixer design principles with a directly coupled motor impeller drive assembly and a cylindrical tank with a specific height to diameter ratio allowing for quick turnaround time for liquid to liquid mixing and powder to liquid mixing Critical upstream application steps e Media preparation e Final formulation steps e Buffer preparation e Harvest vessels e Large volume mixing up to 2 000L Critical downstream application steps e Pooling and liquid transfer e Product suspension e Mixing and storing multiple batches e Buffer preparation e Viral inactivation ThermofFisher SCIENTIFIC HyPerforma S U M options e Powder hanger for 1kg 5kg and 25kg powder bags e AC and DC motor options electrical box only available on AC option e 3x load cell weighing system with summing box options for displaying signal output e Cable management system to o
4. PharmaPure More information is available in the tubing selection guide Tubing size Ranges from 3 18mm 4 in to 25 4 mm 1 in inner diameter in More information is available in the various lengths tubing selection guide Connectors Luer Colder Products Company CPC quick connects SIP connectors More information is available in the tri clamp Kleenpak SmartSite Clave Lynx steam thru CPC steam thru connection system selection guide Gore steam valve Gore Mini TC BioQuate SterilEnz end plug Note the only option for probe port connections is Kleenpak Probe ports line Ports may be added if they are compatible with the hardware The reusable probe port connection addition ports uses a Kleenpak connector Disposable sensors Pressure sensor PendoTECH and Finesse Solutions PendoTECH comes Choice of qualified vendors available standard on 500L and 1 000L S U M DO and pH sensor Finesse Solutions and PreSens pH sensor Mettler Toledo Port sizes Limited engineer to order customization only Dependent on location in bag and fit with hardware e g 1 inch ID port on harvest line Rearrangement of lines on Limited customization possible such as moving sample thermo well port toa Dependent on location in bag and fit existing ports probe tube port or swapping exhaust outlet line with liquid lines with hardware Dip tube lines Limited customization possible Length cannot interfere with impeller and shaft Filters on
5. Bulgin x 120 in LEMO connectors F Single RTD Pt 100 120 in Bulgin connector G Dual RTD Pt 100 120 in DB9 x 120 in Bulgin connectors H Single RTD Pt 100 60 in LEMO connector 5 Load cells and display 0 No load cells A Loads cells no display B Loads cells wall mount display analog output communication C Loads cells wall mount display Allen Bradley communication D Load cells wall mount display device net communication E Loads cells wall mount display Modbus communication F Loads cells wall mount display Profibus communication 6 Powder arm assembly 0 No powder arm assembly A Powder arm assembly 7 Cable management tree 0 No cable management tree A Cable management tree left hand configuration B Cable management tree right hand configuration 8 Communication cable 0 No communication cable A Communication cable 9 Monitoring device 0 No monitoring device A pH monitoring device single channel with display B pH monitoring device dual channel with display C pH and conductivity monitoring device with display 10 Probe clip 0 No probe clip A Probe clip quantity of 4 11 P amp ID tags predefined tags and locations not custom 0 No P amp ID tags A Standard P amp ID tag option predefined not custom 12 Pressure relief valve 0 No pressure relief valve Pressure relief valve max pressure set at 75psi B Pressure relief valve with
6. None Kleenpak aseptic connector KPCHT series female 3 Thermowell 3 2mm in x 6 4mm 1 4 in C Flex x 30cm 12 in Luer and SmartSite valve port small volume sample Bottom drain 12 7mm in x 19 1mm 9 in C Flex x 122cm 48 in Capped 12 7mm 1 2 in MPX body Recirculation line 12 7mm 2 in x 19 1mm 9 in C Flex x 122cm 48 in splits to Capped 12 7mm 2 in MPX insert 12 7mm 2 in x 19 1mm 34 in C Flex x 61cm 24 in and Plugged 12 7mm 1 2 in MPX body 12 7mm in x 19 1mm 9 in C Flex x 30cm 12 in Fill line 12 7mm 2 in x 19 1mm 9 in C Flex x 122cm 48 in 38 1mm 1 in tri clamp SterilEnz 7 Vent filter 6 4mm in x 12 7mm in C Flex x 10 2cm 4 in Sterile hydrophobic vent filter 0 2um PVDF Acro 50 8 Addition line 9 5mm 4 in x 15 9mm 4 in C Flex x 61cm 24 in Plugged 9 5mm 4 in MPX insert Standard open top liners and impeller sleeves Bottom drain X N Lo Ordering information Description Probe ports Film type Cat No Standard open top liner SU O CX3 9 SHS0762 04 IDS Impeller Quick connect fitting Sleeve 34 in inner diameter tubing Ordering information Description Cat No Impeller sleeve for open top mixingt SOL 5H30749 06 The bearing hub needed for open top mixing is automatically supplied with the tank hardware Custom BPC products Category Options capability Tubing type C Flex platinum cured silicone PVC PharMed
7. displays are available as an option for all HyPerforma S U M systems They are normally mounted on the electrical box or a wall and are available with four different interfaces Mettler Toledo IND331 harsh mount load cell display for all S U M systems Ordering information Description Interface serine ere ogo ars aa Analog STD SV501 77 806 eh ie ei o Allen Bradley RIO SV50177 307 with T20VAC US line cord pug Device net SVS0177 308 re tr ier EE TOURS Ethernet IP and Modbus TCP SV50177 309 Mettler Toledo IND331 display harsh mount style Son 250177 310 with 120VAC US line cord plug Powdertainer hook Powdertainer arm Powdertainer arm is available as an option for powder liquid applications It holds the container of powder above the mixer and attaches it to the BPC with a clamp The arm adjusts vertically and swivels to enable convenient lifting of the powdertainer onto the hanger Powdertainer to BPC port clamp Ordering information Description Powdertainer arm for 50L 1 OOOL mixers 5OL 1 OOOL SV5 10020 OH and conductivity monitoring devices METTLER TOLEDO Le Mettler Toledo pH and conductivity sensors with a display monitor are available in single pH dual pH and pH and conductivity configurations The monitor is mounted on the post behind the electrical box and includes a color touch screen and control and alarm management features Ordering information
8. media and Limited engineer to order customization only Choice of filters used to sterilize supplement inlets incoming media or supplements are available Note Not all options are available for all ports It is not possible to customize port type port location chamber dimensions or mixing assembly For additional information please see the selection guides in the BPC Catalog BPC packaging Outer packaging Supplied flat oacked with two polyethylene outer layers Label Description product code lot number expiry date on outer packaging and shipping container Sterilization Irradiation 25 to 38kGy inside outer packaging Shipping container Durable cardboard carton Documentation Certificate of analysis provided with each lot for each delivery HyPerforma S U M options Cable management system Ordering information Description Size Cat No Cable management system 50L 100L SV50992 01 Channels for addition lines Adjustable arm Fes Harvest line hook eal Load cell options Load cells are typically radially mounted in sets of three The mounting location varies slightly for each size in order to allow easy access to the bottom drain or sparging mechanisms and tubing Mettler Toledo MTB load cell for 50L 1 000L S U M units Ordering information Description Size Cat No 3x load cell with summing box without display 50 ee LOE SV50988 01 Load cell displays Harsh mount load cell
9. pressure indicator max pressure set at 75psi Thermo SCIENTIFIC In the United States In Canada For customer service call 1 800 766 7000 For customer service call 1 800 234 7437 To fax an order use 1 800 926 1166 To fax an order use 1 800 463 2996 To order online thermofisher com To order online thermofisher ca ThermoFisher Find out more at thermofisher com sum SCIENTIFIC Caution For manufacturing processing or repacking 2015 Thermo Fisher Scientific Inc All rights reserved All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified Allen Bradley is a trademark of Allen Bradley Company Applisens is a trademark of Applikon B V Corporation BioQuate and PreSens are trademarks of General Electric Company Broadley James is a trademark of Broadley James Corporation Clave is a trademark of ICU Medical Inc Colder Products Company is a trademark of Dover Corporation Finesse Solutions is a trademark of Finesse Solutions Gore is a trademark of W L Gore amp Associates Kleenpak and Acro are trademarks of Pall Corporation Mettler Toledo is a trademark of Mettler Toledo AG PharMed and PharmaPure are trademarks of Saint Gobain Performance Plastics Corporation PendoTECH is a trademark of PendoTECH SmartSite is a trademark of Carefusion 303 Inc Lynx is a trademark of Merck KgAA SterilEnz is a trademark of PAW BioScience Products Inc CO210144 0815
10. 5psi Continuous operating time 21 days mixing time at nominal volume only Ordering information Probe ports Film type Standard powder liquid BPC SO O CX5 14 SH30768 01 Standard powder liquid BPC 5OL O Aegiso 14 SH30973 01 Standard liquid liquid BPC SOI O CX5 14 Sm OAS Te ON Standard liquid liquid BPC SOL O Aegiso 14 SH30983 01 Standard powder liquid BPCt SOL 2 CX5 14 Soll ost Standard powder liquid BPCt SOL S Aegiso 14 She 051072 Standard liquid liquid BPCt SOL 3 CX5 14 one 105e 04 Standard liquid liquid BPCt SOL b Aegiso 14 Sms 10e 0 TAll 50L BPCs with probe ports are designed to allow probes to work properly at 5 1 turndown levels These BPCs are only compatible with the HyPerforma hardware shown in this document If you are using an older version of the S U M hardware do not use these items but refer to the legacy S U M user manual or data sheets Standard 50L BPC for powder liquid applications without probe ports 1 Bottom drain Impeller 3 Recirculation sample line Front face 4 Powder addition port Back face Tubing set inner diameter x outer diameter x length End treatment 1 Bottom drain 12 mm 2 in x 19 1mm in C Flex x 122cm 48 in Capped 12 7mm 2 in MPX body 2 Addition line 12 7mm 2 in x 19 1mm 9 in C Flex x 122cm 48 in Plugged 12 7mm 1 2 in MPX insert 3 Recirculation sample line 12 7mm in x 19 1mm 9 in C Flex x 137cm 54
11. g port receiver with clamp Mixer motor Stainless steel grade 304 outer support container Electrical control panel optional Drive shaft stored inch dimpled jacket side and bottom Probe access window Probe hanger bracket Cart assembly Liquid sight windows Back view of 50L 100L and 200L water jacketed S U M 13 14 15 16 ive 18 19 20 Standard tool set 34 inch 150 in lb square torque wrench load cell and motor cap lockout wrench Bearing hub for open top mixing only Handles Cutout for BPC loading Bottom cutouts pins for BPC attachment and alignment 1 inch tri clamp connection ports for water inlet outlet water jacketed models only Casters 3 swiveling and 2 fixed Bleed valve water jacketed models only Note Models without water jackets include the same features as water jacketed models shown here but without the jacket and inlet outlet ports Optional load cells and cable management system are not shown See the accessories section for more information about these items Standard 50L S U M dimensions water jacketed model 99cm 23 2 in Cart width 98cm 22 8 in Cart length 7 94cm 37 0 in 7 Overall width Top view Standard 50L S U M hardware 35cm 13 8 in Electrical box width 80cm 31 4 in Overall length 4 Front view 50L S U M specifications 216cm 84 9 in P
12. in splits to Capped 12 7mm 2 in MPX insert 12 7mm 2 in x 19 1mm 9 in C Flex x 61cm 24 in and Plugged 12 7mm 1 2 in MPX body 12 7mm 2 in x 19 1mm 9 in C Flex x 30cm 12 in 4 Powder addition port 76 mm 3 in sanitary fitting tri clamp Cap with gasket Standard 50L BPC for liquid liquid applications without probe ports Impeller 1 Bottom drain Front face Back face 2 Fill line Line Tubing set inner diameter x outer diameter x length End treatment 1 Bottom drain 12 7mm in x 19 1mm 4 in C Flex x 122cm 48 in Capped 12 7mm 7 in MPX body 2 Fill line 12 7mm 2 in x 19 1mm 9 in C Flex x 122cm 48 in 38 1mm 1 in tri clamp SterilEnz 3 Vent filter 6 4mm in x 12 7mm 2 in C Flex x 10 2cm 4 in Sterile hydrophobic vent filter 0 2 um PVDF Acro 50 4 Recirculation sample line 12 7mm 2 in x 19 1mm 34 in C Flex x 137cm 54 in splits to Capped 12 7mm 2 in MPX insert 12 7mm 2 in x 19 1mm 34 in C Flex x 61cm 24 in and Plugged 12 7mm in MPX body 12 7mm 2 in x 19 1mm 9 in C Flex x 30cm 12 in 5 Addition line 9 5mm 4 in x 15 9mm 4 in C Flex x 61cm 24 in Plugged 9 5mm 4 in MPX insert Standard 50L BPC for powder liquid applications with probe ports 1 Recirculation line Impeller p 5 Thermowell small volume sample 3 4 Probe ports 2 H 6 Bottom drain 2 Addition line
13. owdertainer height 153cm 60 1 in Motor height 47cm 18 6 in Tank bottom 19cm 7 6 in Cart height Ocm 0 in AC motor DC motor Jacket area full half volume ose m IE 2 STE Dem 0e 2e I Jacket volume 2L 0 53gal 2L 0 53gal E Jacket flow rate at 50 psi 99L min 26 4gal min 99L min 26 4gal min Process connection 1 inch sanitary tri clamp 1 inch sanitary tri clamp z TCU model Maximum heating cooling TF2500 2 800 2 500W TF2500 2 800 2 500W Approximate liquid heat up time 5 37 C 1 2 hr 2 ne Approximate liquid chill down time 37 5 C 2 TE 27 ii 2 RTD or thermocouple 1 8 in 3 18mm OD RTD Pt 100 standard ss Overall width 94 2cm 37 1 in with e box 56 5cm 22 25 in without e box E Overall length 84 3cm 33 2 in with e box 77cm 30 3 in without e box Overall height 198 6cm 78 2 in 3 Dry skid weight mass 152kg 3351b 171kg 376lb 152kg 3351b 171kg 376lb D Wet skid weight rated working volume mass 202kg 445lb 221kg 486lb 202kg 445lb 221kg 486lb Ceiling height required for standard drive shaft loading 228 6cm 90 in tra M Senne 120 240V single phase 10A Dependent on controller M T AN Fe a 12mm diameter x 215 235mm insertion length x 13 5PG pipe thread Operating temperature range 2 40 C 0 1 C 86 104 C 0 2 F ees Motor speed 30 350rpm Es lt Volume range 10 50L g S S Maximum bag pressure 0 03 bar 0
14. ps D must be in place to close off probe ports 5 G Ordering information Description Cat No Heavy duty tubing clamp single SV20664 01 Heavy duty tubing clamps 10 pack SV20664 04 Configuration table for made to order S U M hardware Single Use Mixer SUM HHHH X OX X X X XK XK XK X Vessel size 0050 0100 0200 0500 1000 or 2000 4 digits in liters followed by a dot 1 Vessel type material A Non jacketed 304 SST standard tank and cart are 304 SST B Jacketed 304 SST standard tank and cart are 304 SST C Non jacketed 316 SST tank and cart are 316 SST D Jacketed 316 SST tank and cart are 316 SST 2 Motor electrical enclosure mount DC motor no electrical enclosure B AC motor no electrical enclosure C AC motor 120VAC electrical enclosure right hand configuration standard D AC motor 240VAC electrical enclosure right hand configuration standard E AC motor 120VAC electrical enclosure left hand configuration F AC motor 240VAC electrical enclosure left hand configuration 3 Drive shaft A 1 piece drive shaft SST B 2 piece drive shaft SST C 3 piece drive shaft SST 4 RTD 0 No RTD Single RTD Pt 100 60 in Bulgin connector standard B Dual RTD Pt 100 120 in DB9 connector x 120 in open lead wires C Dual RTD Pt 100 120 in Bulgin x 120 in Bulgin connectors D Dual RTD Pt 100 120 in DB9 x 60 in Bulgin connectors E Dual RTD Pt 100 120 in
15. rganize process tubing lines e Available in either water jacketed or non jacketed no heat transfer design e pH and conductivity probes and display e Open top or closed top Thermo Scientific BioProcess Container BPC design e BPC available in Thermo Scientific CX5 14 Film and Aegis 5 14 Film options Options outside of the above list may be reviewed with a Thermo Fisher Scientific sales representative and considered for customizations to the standard mixer design Ordering information Standard S U M hardware units Non jacketed DC motor without load cell S IE SUMO050 9001 Jacketed DC motor without load cell sole SUMO0050 9002 Non jacketed 120VAC AC motor without load cell S E SUMOO50 9003 Jacketed 120VAC AC motor without load cell SOL SUMO0050 9004 Non jacketed 240VAC AC motor without load cell SO SUMOO50 9005 Jacketed 240VAC AC motor without load cell SOL SUMO0050 9006 Note Models without water jackets may have slightly different dimensions than the water jacketed model shown here See the drawings provided with your unit for exact dimensions for non jacketed models Non jacketed models do not have the capability to heat or cool the liquid inside the tank Design features of the 50L 100L and 200L S U M Front view of 50L 100L and 200L water jacketed S U M CON ON ON ES CON YS O 11 12 Powdertainer arm optional Mixing assembly with shield Bearin
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