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1. Mode 008A 06 CV IMAGING INSERT Model 008A 14 The gel insert receives a standard B9 dose gel container The con tainer is made from oxygen resistant plastic Clear walls enable visual inspection of the irradiated gel The container can be scanned in CT MRI and optical laser scanners The PET CT target insert includes hollow spheres of known volume that can be filled with 0 5 2 and 8 ml of radionuclides to simulate cold or hot spherical lesions The 4D CT QA insert option provides a quantitative quality control method for the 4D CT scanner s image binning function The 4D CT QA device consists of an acrylic tube with static fiducials in a grid pat tern and a moving rod with a single fiducial The motion of the single fiducial is set up to match positions of the static fiducials on the acrylic tube at the maximum inhale and maximum exhale phases of the breathing cycle Using the 4D CT QA insert users can optimize safety margins during treatment planning of moving tumors by identifying misalignments in 4D CT binning as small as 0 5 mm The maximum displacement is 80 mm in IS direction and 20 mm in both AP and LR directions The moving cylinder can also be used to investigate artifacts volumes and shapes during different breathing motions including patient specific motion profiles because of it s regular size and cylindrical shape Cutaway to show internal structure of rods m l Front View 15 c
2. best scenario to simulate the real 3D waveform and simulated volume is achieved AM 9 Import Motion Data ei Aula N iA nn Click Drag to select Ctrl Click topan Mimos waveform 80 100 120 Sample Rate 30 Name Custom Name of imported waveform User or software assigned Data Column Selection Smoothing Un smoothed Data O Maximum Smoothing Degree 100 Sampling rate of recorded data by Motion Control Software Used to reconstruct waveform Range 1 to 100 True 3D Target Motion In A Solid Epoxy Phantom A lung equivalent solid epoxy rod containing a soft tissue target and or dosimeter is moved within a lobe of similar lung equivalent material in a solid phantom body Motion of the lung material is radiographi cally invisible due to its matching density with the surrounding material however the target can be resolved given its density difference The center of the target is positioned off central axis of the rod Complex 3D motions can be achieved thru simultaneous indepen dently controlled linear translation and rotation as AP 68 Tumor 5mm LR I 10 2 2 mm Moving Rod x Inferior Superi superior up to 50mm 8 DO vak d ONORE EP 5 A 6 SoD SP Within the CIRS Motion Control software the user inputs desired range of target motion in the inferior superior IS anterior posterior AP and the left right LR directions Using these in
3. cortical and trabecular bone External alignment marks with embedded fiducials facilitate rapid orientation with positioning lasers and phantom image registration Tissue equivalent phantom body with anthropo morphic spine external alignment marks and CT fiducials for phantom image registration pa Cut away to show target location Linear Attenuation Coefficients To Reference Tissues Electron Density Density Ratio ones g cc x 10423 to H O per cc Plastic 1 04 3 99 1 008 Water DT Lung 0 21 0 69 0 207 Cortical 1 91 5 95 1 782 Bone Trabecular 1 20 3 86 1 156 Bone Soft tissue 1 06 3 43 1 028 target A Front View 30 cm 20 cm Plastic Trabecular Cortical Lung Water DT Bone Bone Inhale En MeV Ratio Ratio ia Ratio 0 05 100 8 100 0 100 00 100 3 0 06 1005 1007 100 00 101 1 0 08 100 3 100 3 99 99 101 9 0 10 100 2 100 3 99 99 0222 0 15 100 0 100 4 100 0 102 5 0 20 100 1 100 5 99 99 102 6 0 40 100 1 100 5 100 0 102 7 0 60 100 1 100S 100 0 102 6 0 80 100 1 100 4 100 0 102 7 1 00 100 1 100 5 100 0 OZ Te 1 50 100 1 100 5 100 0 102 7 2 00 100 1 005 99 99 102 6 4 00 100 0 100 5 99 92 102 1 6 00 99 8 100 3 99 85 101 6 8 00 99 7 100 0 99 79 101 2 10 0 99 6 100 0 99 73 100 7 15 0 99 2 99 78 99 61 100 0 20 0 99 1 99 58 99 55 102 7 ICRP 23 Report of the Task Gr
4. planning and dose delivery in image guided radiation therapy The phantom body represents an average human thorax in shape proportion and composi tion A lung equivalent rod containing a spherical target and or various detectors is inserted into the lung equivalent lobe of the phantom The body is connected to a motion actuator box that induces three dimensional target motion through linear translation and rotation of the lung equivalent rod Motion of the rod itself is radiographically invisible due to its matching density with the surrounding material The target and its motion given its density difference can be resolved Target and surrogate motion are independently controlled with CIRS Motion Control Soft ware The graphical user interface provides an unlimited variety of motions while simplifying the operation of the Dynamic Thorax Phantom to an intuitive level Patient specific profiles are easily imported and there is no need to make hardware adjustments or have special programming skills The Dynamic Thorax Phantom offers ease of use and portability as well as a flexible selec tion of motion profiles and dosimeter options All components are packaged in a protective case The system requires minimal set up and can be ready to use in minutes The CIRS Model 008A Dynamic Thorax Phantom presents a sophisticated solution for the complex challenges and emerging technologies in Image Guided Radiation Therapy Computerized Imaging Referenc
5. CRO CHAMBER configured lung equivalent rod with set of 3 target inserts Model B 9 Dose Gel Container Lung equivalent Imaging Rod with set of 3 target inserts PET CT configured lung equivalent rod with set of 3 target inserts 008A 19 Ball Cube configured lung equivalent rod for film dosimetry 008A 22 SBRT Insert with set of 3 target inserts ADDITIONAL OPTIONS BO Dose Gel Container Compatible with CIRS Model 008 11 008A 153 Replacement Push Rod 008A 125 Chest plate with reflective 11 5 mm tracker balls 008A 17 Adjustable legs for 008A only 008 18 Model 008 upgrade to 008A 008P 06 Dynamic Pelvis Body 008A 23 Upgrade Program The original Model 008 Dynamic Thorax Phantom can be upgraded to the Model 008A The Model 008 featured surrogate motion that was coupled to the tumor motion The upgrade will provide users with independently programmable surrogate motion and Motion Con trol Software that allows unlimited variety of motion profiles including easy download of patient specific motions The upgrade will provide users with e Exchange of 008 2 axis Controller with 008A 3 axis Dynamic Motion Controller e CIRS Motion Control Software e Surrogate motion platform e Mounting and connecting surrogate motion platform on motion actuator e Minor hardware upgrade e Cleaning and testing of all components Users must return the entire system to CIRS Contact CIRS to re ceive pricing and an RMA number LIMITED WARRA
6. Dynamic Thorax Phantom Model 008A CO u Lente IMAGE ACQUISITION TREATMENT PLANNING DOSE DELIVERY Strict QA procedures for the imaging planning and delivery of radiotherapy using respiratory management devices are required to ensure the safe and effective use of these devices AAPM TG 76 report The management of respiratory motion in radiation oncology re LO B LOCALIZE IGRT Patent US 7 151 258 B2 2428 Almeda Avenue Suite 316 Norfolk Virginia 23513 e USA Tel 800617 1177 737 0999 21693 Fav 797 897 0529 WWW CIRSINC COM CIRS Tissue Simulation amp Phantom Technology CAPABILITIES e Commission 4D imaging and 4D radiotherapy systems e Quantify volumetric and posi tional aliasing of CT in the presence of 3D target motion e Evaluate static and dynamic target localization accuracy of onboard imaging systems e Test accuracy and consistency of tumor tracking and respira tory gating devices e Assess dosimetric accuracy of temporally modulated radiation therapy e Train and evaluate personnel during implementation of new equipment and techniques Overview The CIRS Dynamic Thorax Phantom is a precision instrument for investigating and minimiz ing the impact of tumor motion inside the lung It provides known accurate and repeat able three dimensional target motion inside a tissue equivalent phantom It is designed for comprehensive analysis of image acquisition
7. NTY All standard CIRS products and accessories are warranted by CIRS against defects in material and workmanship for a period as specified below During the warranty period the manufacturer will repair or at its option replace at no charge a product containing such defect provided it is returned transportation prepaid to the manufacturer Products repaired in warranty will be returned transportation prepaid There are no warranties expressed or implied including without limitation any implied warranty of merchantability or fitness which extend beyond the description on the face hereof This expressed warranty excludes coverage of and does not provide relief for incidental or consequential damages of any kind or nature including but not limited to loss of use loss of sales or inconve nience The exclusive remedy of the purchaser is limited to repair recalibration or replacement of the product at manufacturer s option This warranty does not apply if the product as determined by the manufacturer is defective because of normal wear accident misuse or modification Non Warranty Service If repairs or replacement not covered by this warranty are required a repair estimate will be submitted for approval before proceeding with said repair or replacement Product Warranty Period Non Standard or customized products 3 months Training Phantoms and Disposable Products Electrical Products and Dynamic Phantoms 12 months A
8. Radiothera py amp Oncology at Meeting Vol 76 Supplement 2 September 2005 11 MODEL 008A FEATURES Complex 3D tumor motion within the lung Sub millimeter accuracy and reproducibility Motion software enables different cycles amplitudes and wave forms Tissue equivalent from 50 keV to 15 MeV Compatible with TLD MOSFET Dose Gel micro chamber PET CT targets and film Surrogate breathing platform accommodates numerous gating devices CIRS COMPUTERIZED IMAGING REFERENCE SYSTEMS INC 2428 Almeda Avenue Suite 316 Norfolk Virginia 23513 USA Toll Free 800 617 1177 Tel 757 855 2765 Fax 757 857 0523 E mail admin cirsinc com www cirsinc com Technical Assistance 1 800 617 1177 Computerized Imaging Reference Systems Inc has 2013 Computerized Imaging Reference Systems Inc All rights been Certified by UL DQS Inc to ISO 9001 2008 reserved All brand names product names or trademarks belong Certificate Registration No 10000905 QM08 to their respective holders Specifications subject to change without notice Publication 008A PB 111814
9. antom using slider bars or by entering desired values within the limits of the system Five different waveforms are available from a standard pull down menu An unlimited number of clinically relevant and patient specific wave forms or correlation models can be imported from tab delimited or comma separated file formats There are also waveform editing smoothing and analyzing tools to ease the optimization of custom waveforms All motion files can be saved for future use The software provides a convenient real time graphic display with relevant information about the waveform selected for each direction of simulated tumor In addition the ROI analyzing function provides the time spent by the target between two chosen amplitudes and the average time weighted position for that particular ROI Users can instantly start stop or pause the motion at any time New start positions can be graphically selected and applied making the device very useful for static test as well as dynamic testing Users can also select the number of cycles to be looped by entering the desired value or choose continuous looping 1 million cycles Real time display of target and surrogate motion parameters Research Mode to import 3D recorded waveforms The Advanced Motion Parameters window contains a Research Mode that allows researchers to import 3D x y z recorded waveforms Once the research mode is selected the software automatically calcu lates the
10. e Systems Inc is recognized world wide for tissue simulation technology and is the leader in the manufacture of phantoms and simulators for medical imaging and radiotherapy www cirsinc com Easy To Use Software Dynamic Phantom Motion Control Selection Thorax or Pelvis O CIRS Motion Control Rie Moun View see ON Sai Col Val eee tara Ario Chacila Time Praca Sat byt Pipiri bat Pipita Caen Penha i Ciian Piers va R dura Parie R dg Praltige Fabi Tortoli Tona Fili Toral Tune FO Tatai Tie i i i b 4 a i i 30 20 10 CORE Graphical user interface simplifies operation of the Model 008A Adjust motion amplitude cycle time and phase shift with pull down menus and slider bars Nal ayya aTa Cintora 1 ii OS Shoe aa a pesceriage of cycle line DI Shor aa limn 51 Protaticral Star Position ua SIE C Lock its porion Feiaaich Mode Erabi fa artenci potenti and lateral r and phare pali hi tit pet iper rta Start CIRS Motion Contra Instantly Start Stop Pause or Loop motion USER FRIENDLY MOTION CONTROL The Dynamic Thorax Phantom is operated using CIRS Motion Control Software Suite a user friendly graphical user interface that can be installed on any computer running Windows OS Upon installation the user has the option to select the phantom that is to be controlled by the software Amplitude cycle time and phase shift can be applied to both the surrogate and main ph
11. he user to select the phantom that is to be controlled by the software Model 008P 06 Model 008A Specifications Overall Dimensions 67 cm x 32 cm x 28 cm 26 x 13 x 11 Overall Weight 17 2 kg 87 9 Ib Power 110 250 VAC 50 60 Hz Amplitude IS 25 mm Amplitude AP LR a OAN Amplitude Surro 25 MM gate Max Surrogate SAE KC 2 Ie Platform Load Motion Accuracy 0 1 mm Cycle Time 1 adjusted based on amplitude Waveforms sin t 1 2cos4 t 1 2cos6 t sawtooth Sharkfin CIRS Motion Control Software System bit Requirements Pentium 3 or equivalent 512 MB RAM 2 MB of available disk space Windows XP Vista Windows 7 82 or 64 INCLUDED WITH MODEL 008A Dosimeter rods not included FJ cont unit it frre insta 0 2204 50 60 _ i memener Pfr Jocaingacustorbox e ee S i Tors morn como Stare CDRom h mewn OOOO Pt rones Pfs Nemonesne one O O OOOO i emeomaess OOO h uscite emi E usbenenderteminis 1 Begotmiscetanecue repacement stero E mesono i Povere O Ti esea To eevee 10 Ordering Information INTERCHANGEABLE INSERT OPTIONS Note Customers must complete their order with the purchase of at least one 1 interchangeable insert option Refer to separate CIRS cavity and plug code list for available chamber cavities 008A 05 MOSFET configured lung equivalent rod with set of 3 target inserts 008A 06 CV MI
12. ll other standard products 48 months Plastic Water 60 months REFERENCES Munoz C et al Evaluation of Positional Accuracy in Moving Tumors Using a CIRS Dynamic Phantom Poster presented Cyberknife User s Meeting January 2007 Tanyi James A et al Phantom investigation of 3D motion dependent volume aliasing during CT simula tion for radiation therapy planning Radiation Oncology 2007 2 10 Chuang C et al The use of a new dynamic motion phantom for patient specific QA in tracking therapy 2006 AAPM Abstract ID No 4639 Wang Z et al Verifying Internal Target Volume using Cone Beam CT for Stereotactic Body Radiotherapy Treatment 2006 AAPM Abstract ID No 5263 Poster SU EE A1 4 Tanyi James A et al Dosimetric Evaluation of Target Dose in Stereotactic Body Radiation Therapy SBRT of Lung Lesions Using a Dynamic Motion Anthropomorphic Phantom 2004 AAPM PO T 143 Poster Tanyi James A et al Phantom Investigation of Three Dimensional Motion Induced Dose Discrepancy During Intensity Modulated Radiation Therapy Dose Delivery Poster presented at 2006 annual AAPM meeting Orlando FL July 2006 Tanyi James A et al Phantom Investigation of Three Dimensional Motion Dependent Volume Aliasing During CT Simulation for Radiation Therapy Planning Poster presented at 2006 annual AAPM meeting Orlando FL July 2006 Varchena V et al A novel Dynamic Thorax phantom for 3D CRT and IMRT of lung lesions
13. m Section A A a i Front View Section A A e Front View 15 cm Section A A RADIOCHROMIC FILM INSERT Model 008A 08 Sagittal Film Front View Section A A BALL CUBE FILM INSERT Model 008A 19 ae i bero Front View Section A A GEL DOSIMETRY INSERT Model 008A 11 Front View Section A A PET CT INSERT Model 008A 15 e Front View Section A A 4D CT QA INSERT Model 008A 12 US Patent 7699522 B2 e Front View Section A A Interchangeable Inserts for QA amp Dosimetry SBRT INSERT Model 008A 22 The SBRT Insert contains a milled cavity that accommodates four interchangeable inserts three film inserts and one nanoDot OSL do simeter insert The three film inserts are included with the Model 008A 22 Each insert contains an embedded spherical soft tissue target respectively 1 cm 2 cm and 3 cm diameter Targets are positioned within inserts so the isocenter is at 15 mm from longitudinal axis of rotation of SBRT insert to enable AP and LAT motion nanoDOT OSL DOSIMETRY 3 CM TARGET INSERT The nanoDot OSL Dosimetery 3 cm Target Insert Model 008A 23 can be purchased separately for use with the Model 008A 22 The insert is split in two parts of different thicknesses to allow the po sitioning of nanoDot ISO centers in a mid plane tha
14. oup on Reference Man 1975 Woodard H Q White D R The Composition of Body Tissues The British Journal of Radiology 1986 59 1209 1219 Interchangeable Inserts for QA amp Dosimetry There are nine interchangeable rods available for use with the phan tom Eight are made from lung equivalent epoxy and all measure 63 5 mm in diameter The lung equivalent inserts accommodate either MOSFET micro chamber film PET CT targets or gel dosimeters The rods are easily connected and aligned to the drive shaft All rods can be quickly interchanged The MOSFET micro chamber and SBRT inserts are designed for target acquisition and quantitative dose measurements Each rod includes a 1 2 and 3 cm soft tissue equivalent target insert Each insert is machined to receive the dosimeter at the center of the target volume The imaging insert is designed to provide solid known diameter targets for imaging applications and includes a 1 2 and 3 cm soft tissue equivalent target insert The Radiochromic film insert holds a single 135 X 55 mm film at midplane along the long axis The homogeneous rod has 3 fiducials that are radiographically visible and enable film to plan registration The rod is drilled to allow indentation of the film relative to the implanted fiducials The Ball Cube Film insert contains a 25 mm diameter spherical target that accommodates two pre cut Radiochromic films MOSFET INSERT Mode 008A 05 MICRO CHAMBER INSERT
15. puts the soft ware computes the rotational angles based on known distance of the target center relative to the central axis of the rod Rotation instruction is sent to the actuator by the software e Maximum IS motion is 50 mm e Maximum AP LR motion is 10 mm via rotation e Minimum cycle time is 1 second e Maximum cycle time is unlimited Independently Controlled Surrogate Motion The surrogate motion is mechanically independent of tumor motion and programmable through the CIRS Motion Control Software The surrogate platform can emulate either chest wall or diaphragmatic motion by manually changing its position Various gating devices can be attached to the platform The platform thickness and density allows for CT simulation of the diaphragm This feature provides even greater flexibility to the clinician and is useful in assessing correlation between surrogate and tumor motion e Maximum surrogate motion 50 mm e Minimum cycle time is 1 second e Maximum cycle time is unlimited Proven Tissue Equivalent Phantom Technology The phantom body approximates the average human thorax in both size and structure using simplified geometries It is constructed of proprietary tissue equiva lent epoxy materials Linear attenuations of the simulated tissues are within 1 of actual attenuation for water and bone and within 3 for lung from 50 keV to 15 MeV For internal landmarks the phantom contains a 3D anthropomorphic spine with
16. t goes through the center of the 3 cm target and the mid plane of the SBRT Rod The nanoDot pockets are machined 4 1 mm apart along two per pendicular axes to allow measurements inside the target and in the penumbra in both sagittal and coronal planes The insert has one interior flat face engraved with lines that correspond with the size of the 2D bar codes which are applied by nanoDot OSL dosimeters manufacturer For proper alignment between nanoDot ISO centers and target center nanoDot dosimeters should be inserted into the pockets aligning the 2D bar codes with these engraved marks Film inserts hold a single 140 X 54 mm film at mid plane along the long axis One half of each film insert has 8 fiducials that are radiographi cally visible and enable film to plan registration The other half of each film insert is drilled to allow indentation of the film relative to the implanted fiducials All sides and bottom edges of the inserts are rounded with different radiuses for unique match with SBRT rod cavity Advanced Electromechanical Components ACTUATOR Housed within anodized aluminum enclosures the actuator contains bipolar stepper motors that enable linear motion accuracy of 0 05 mm and rotational motion accuracy of 0 2 Linear motion of the target in the IS direction can be isolated from rotational motion in the axial plane in both frequency and amplitude Surrogate motion is indepen dently controlled Motions can be s
17. ynchronized to one another with accuracy better than 20 msec Motion cycle time accuracy is better than 5 msec Optical sensors ensure precise mechanical position ing The actuator is designed for continuous operation If not manually stopped and reset by the user it will perform 1000000 in continuous mode cycles then stop automatically Adjustable legs are available Legs can be useful in leveling the phan tom on curved imaging couches The optional chest plate can be useful for collecting chest motion and breathing data using optical tracking systems CONTROLLER Motions are generated through a three axis motion controller A USB port enables interfacing with most computers The controller sends instructions as well as supplies and conditions power to the actuator thru a 25 pin serial cable The motion controller can be fully operated through CIRS Motion Control Software see page 3 from a distance of up to 70 feet with the Ethernet USB cable provided DYNAMIC PELVIS PHANTOM The Model 008P 06 Dynamic Pelvis Phantom body represents an average human pelvis in shape proportion and composition A water equivalent Cube containing a prostate gland and or various detectors is inserted into the pelvic cavity of the phantom The cube is connect ed to the motion actuator box to induce two dimensional target mo tion through rotation of the water equivalent cube The CIRS Motion Control Software has been pre programmed to allow t

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