Home

Ferritometer® Biomagnetic Liver Susceptometer

1. GANTRY ASSEMBLY TORINO LIVER IRON ds TT 2047 G01 T T T F 7 Figure 2 4 Gantry Assembly 2 5 1 1 Pumping of dewar Dewars are shipped with the vacuum space evacuated Atmospheric pressure actually holds the end pieces top and bottom plates of the dewar together The vacuum space is evacuated via the evacuation valve on the dewar top plate The vacuum is maintained using two large gasket seals on either end of the dewar outer case tube IMPORTANT Please make certain that the dewar tail does not twist relative to the top plate if the pressure is released If the dewar vacuum has deteriorated while the dewar was warm usually due to shipping damage it will be noticeable during liquid nitrogen precool as the outside walls of the dewar will Model 5700 Biosusceptometer page 12 of 76 get cold and perhaps even condense water Any attempt to transfer helium under these conditions will be futile The outside walls will get quite cold but no helium will collect in the dewar If this occurs contact your local Tristan representative before proceeding Since helium can diffuse through warm fiberglass do not let helium gas remain in a warm dewar for extended periods The elements in the dewar vacuum space may outgas particularly at room temperature For this reason an air getter material is in the vacuum space to adsorb air and even helium
2. p CORRIDOR TRISTAN TECHNOLOGIES 4 sores ALE TORNIO LIVER IRON D z047 s01 Tet x T a 3 2 T Figure 2 3 Room Layout 2 1 3 Power Requirements e 200V 4 5VA for Main Rack and computers e 200V 2 4VA for water bag assembly An electrical ground to good earth ground via spike must be provided near the data acquisition rack For safety purposes an interruptible circuit breaker should be provided at the wall power This will connect to a single button Red Button on the side of the gantry that makes a contact closure when activated 2 2 Items Supplied in the model 5700 Biosusceptometer Rack Instruments Model 5700 Biosusceptometer page 9 of 76 Knurr 19 Rack model MR19696C Hewlett Packard Signal Generator model HP33120A Hewlett Packard Power Supply 1 magnet model HP6541A Hewlett Packard Power Supply 2 z transducer flow meter model HPE3630A Power Supply 3 Power supply 4 Kollmorgen Motor Controller single axis model KXA 80 10 20 Tristan iMAG SQUID Controller model iMC 303 R 4 01 Chksum 0AD5 American Magnetics Level Meter model 135 Sierra Instruments Helium Flow Meter model 824 CE 13 OV1 Computer system Dell CPU model Optiplex in rack Xpert graphics cards amp superdrive Dell CPU model Optiplex amp superdrive Dell Monitor la model M99
3. on KXA Amp 1 2 3 4 Lis 6 7 8 GND 9 10 ENABLE o GND 2 i cw 13 NC J GC GND T Panel Mount Z UPPER Ka Kei LIMIT SW i NO 17 Bed Mount ES ION 2 Z LOWER A cua Bed Mount LIMIT SW NO Bed amp Dewar Safety Switches 2047 Torino Liver Fe S ZE Date DWG NO REV 28 June 99 2047 E16 Tony Ewing SHEET 10F1 Figure 9 1 System Safety Schematic 9 1 Bed Motion The bed should never be raised such that any object touches to bottom of the dewar or water bag or damages the dewar tail Model 5700 Biosusceptometer page 60 of 76 Care should be taken not to trap the patient between the bed and dewar tail There are emergency stops for the bed and water bag on the gantry If there is any indication of potential injury these stops will interrupt the bed motion The Emergency Stop a large RED button us interlocked so that when it is mechanically reset power is not restored to the bed There is a reset on the power interruptor that must be activated in order to restore power to the bed This prevents the bed from powering up immediately after the Emergency Stop is reset When measuring patients the bed should not be raised as to lift the patient into the dewar tail If the patient complains or indicates significant discomfort due to pressure against the dewar tail the measure
4. Helium Flow Meter WAT S s Magnet Controller Se E Ke o S DAC 16 Bit 100kS sec Waterbag System SQUID ATA A A A A Signals SQUID Sensors 3 Detection Coils and Magnet flow control 7 Flow temperature Control control Analog Reference Locator Loops water Bag Signals Hydrostatic Lo Control Liver Flow control Motorized Patient Bed onof Handheld Switch Waveform Controller p Generators Bed motion Up and Down Waterbag Fill and Empty Reset Measurement Position Transducer je Control lt gt Motion Limits be Position Motor Controller Digital VO Figure 1 5 System Schematic 2 Preparation for Use or Return 2 1 Site Requirements 2 1 1 Site Selection The model 5700 biosusceptometer is a detector of magnetic flux that that is amplified and transformed by the SQUID system into a room temperature output voltage This voltage is directly related to the iron stores in the liver Signals can also be induced from sources other than the liver in particular electrom
5. 456307 0 133490 0 002845 0 017362 0 000630 7 177223 0 139167 0 000347 0 032774 0 000034 7 177242 7 177541 7 174560 7 168201 1 760509 573286 0 133679 0 002786 0 017843 0 000407 7 217073 0 140362 0 000072 0 038315 0 000039 7 216568 7 216508 7 213586 7 206185 1 725134 707550 0 133805 0 002931 0 017949 0 000490 7 256492 0 140321 0 000131 0 035638 0 000087 7 257251 7 256658 7 254097 7 251064 1 729020 825395 0 134240 0 002873 0 018215 0 000286 7 295875 0 140144 0 000113 0 033460 0 000081 7 297193 7 296469 7 294388 7 295979 1 788254 939250 0 134403 0 002802 0 018200 0 000205 7 335901 0 139886 0 000069 0 032155 0 000129 7 337694 7 337372 7 335130 7 336670 1 828655 038929 0 134697 0 002705 0 018399 0 000225 7 376021 0 140539 0 000032 0 024979 0 000087 7 376469 7 376687 7 373912 7 369640 1 828554 123878 0 134777 0 002985 0 018688 0 000358 7 416467 0 141482 0 000093 0 026225 0 000054 7 415526 7 415761 7 412679 7 404709 1 798194 218580 0 134785 0 002717 0 018718 0 000439 7 456491 0 141772 0 000138 0 026077 0 000079 7 456014 7 455738 7 452913 7 448495 1 769343 301455 0 135039 0 002761 0 018988 0 000245 7 495792 0 141203 0 000141 0 022885 0 000056 7 496873 7 496121 7 493898 7 494170 1 797024 386051 0 135053 0 002747 0 019160 0 000469 7 535330 0 140728 0 000187 0 024612 0 000075 7 537567 7 536984 7 534905 7 537218 1 854529 456742 0 135408 0 002809 0 019238 0 000348 7 575831 0 141084 0 000040 0 017938 0 000165 7 576693 7 576706 7 574171 7 572543 1 894827 537369 0 135
6. Model 5700 Biosusceptometer PRESS 000306 000398 000271 000162 000288 000114 000152 000210 001125 000368 000795 001858 000634 000573 000235 000311 000346 000333 000019 000332 000289 000138 000334 000207 000407 000521 000463 000339 000428 000434 000348 000324 000158 4 891333 900653 910071 920519 933038 947700 964764 981929 999636 019021 040915 064784 091005 116991 144237 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 DSQA 884991 173392 205118 238046 272636 307847 345125 384189 423605 463116 502920 542107 581644 622316 663125 702999 741829 780705 Total body fat or im edance or 0 Number of actual runs lt 10 100 16 Machine Parameters file name System Parameters file name LL or PT position transducer or TM time Closest distance for PT Equivalent PT voltage V LL z source current at start Organ liver spleen heart Skin organ distance mm Skin organ distance error mm Organ geometry 1 13 Organ ellipsoid axis a or spherical Radius Organ ellipsoid axis b cm Organ ellipsoid axis c cm Thorax geometry 1 13 Thorax ellipsoid axis a or spherical Radius Thorax ellipsoid axis b cm Thorax ellipsoid axis c cm Online
7. N I PCI 232 4 Isolated Multi function Parent 1 N I PCI 232 4 Isolated Communications Port COM5 1 N I PCI 232 4 Isolated Communications Port COM6 1 N I PCI 232 4 Isolated Communications Port COM8 2 PSP PS 2 3 Numeric data processor 4 Primary IDE controller dual fifo 4 Intel r 82801AA Ultra ATA Controller 5 Secondary IDE controller dual fifo 5 Intel r 82801AA Ultra ATA Controller kk ck ck ck ck ck ck ck ck ko k kk kk kk IO PORT SUMMARY Ck ck ckck ck ck ck ck ck ck kk kk kk kk I O Port Usage Summary 0000h 001F 0020h 003F 0040h 005F 0060h 0060 0061h 0061 0062h 0063 0064h 0064 0065h 006F 0070h 007F 0080h 009F 00A0h 00BF 00C0h 00DF 00E0h 00EF 00F0h 00FF 0170h 0177 0170h 0177 01F0h 01F7 01F0h 01F7 02F8h 02FF 0376h 0376 0376h 0376 0378h 037F 03B0h 03BB 03C0h 03DF 03F0h 03F5 03F6h 03F6 03F6h 03F6 03F7h 03F7 03F8h 03FF 04D0h 04D1 0778h 077F 0800h 085F 0860h 08FF 0C00h 0C7F OCF8h OCFF DCDOh DCDF E000h EFFF E000h EOFF ECOOh EC7F ECC8h ECCF ECC8h ECCF ECD8h ECDF ECD8h ECDF ECE8h ECEF ECE8h ECEF ECF8h ECFF ECF8h ECFF FFAOh FFAT7 FFAOh FFAF FFASh FFAF Model 5700 Biosusceptometer n SO vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd vd h Direct memory access controller Programmable interrupt controller System timer Standard 101 102 Key or Microsoft N
8. S C Filament R 121 4 Ohm V Figure 3 5 Liquid helium level meter block diagram DO NOT LEAVE LEVEL METER IN THE CONTINUOUS POSITION When turned on the level detector passes a 75 mA current though a thin superconducting wire When immersed in liquid helium the wire remains superconducting Any portion of the wire not in liquid does not have sufficient cooling to remain superconducting and becomes resistive with a resistance of 4 5 Q cm length Since the active length of the sensor installed on this probe is 30 cm a 67 full reading is equivalent to 20 cm being superconducting and 10 cm being normal with a resistance of 45 With a 75 mA current this generates 250 mW equivalent to a boiloff of an additional 8 4 liters day of liquid helium Leaving the level meter in the continuous position with a 0 reading will generate heat equivalent to an additional 25 liters day helium boiloff Instead switch the model 135 meter toggle switch to INTERVAL Below is presented a wiring diagram and pin assignment for the level meter connector Model 5700 Biosusceptometer page 24 of 76 FACE SIDE REL BLK WHT Figure 3 6 Helium level meter connector 3 5 Taking the System Out of Service 3 5 1 Removing field from the magnet The removal of the field from the magnet must be done by matching the current already existing in the magnet and then running the magnet heat switch normal NOTICE one switch and one conn
9. T n GEL M c PEE 1 KT Pu rpose oftheMADAL sense aids nnen EA eee eeb eia dus d i imei dde 1 1 2 Overview of Components and the System 1 1 3 The SQUID Detection System and Electronics eee eee eee eee eee ette nnne 2 1 4 The Water Bellows and Re EE 2 1 5 Position Locator sintio 3 1 6 Patient Bed and Measurement Motion Control 3 1 7 Gantry and Vibration Isolation System este ode ge be e deen 4 1 8 Computer Control and Data Collection System 4 1 5 1 Component Lem Oia 4 1 8 2 TheSOUlDDetectionSystem amp Electronics 5 13 The Water Bellows amp COntr ols smetten aa ta sd 3 TBA 7 POSO Locator EE 5 1 8 5 Patient Bed amp Measurement Motion Control eres 5 1 8 6 Gantry amp Vibration Isolation System 6 1 8 7 Computer Control and Data Collection System eene 6 A O 6 2 Preparation Tor Use Or NEEDE EE EE 7 Doli Site Reguirements eigene EE Ea A NEE 7 E Site Selection E 7 21 2 Space ERT E 9 2 1 3 Power E Uu CR 9 2 2 Items Supplied in the model 5700 Biosusceptometer esee 9 2a mitral Specto einne EEN 10 o E 11 2 PEE PATA OM fot US iii ide 12 2 5 1 Installation of Gantry a ak azsa da dan sa lasa RES Sen SI et SEENEN va SABA 12 2 5 2 Installatiomof water bas ee yarma a edentate ete ame 14 2 95 Preparation OF s bject DEC ante e ce tos alan dilli lal da ded e 15 E WE 16 2 0 yy t NEP 16 2 6 1 Repackaging
10. bed and electronics photo Model 5700 Biosusceptometer page 1 of 76 1 3 The SQUID Detection System and Electronics SQUID detection systems are extremely sensitive detectors of magnetic flux They operate at cryogenic temperatures and utilize the Josephson Effect to achieve the ability to detect changes in magnetic field smaller than 10 tesla The SQUID system in the model 5700 biosusceptometer is comprised of three channels of liquid helium SQUIDs with a highly stable integrated superconducting magnet system for applying a static dc magnetic field The entire structure is integrated into a magnetically clean dewar and cooled by a liquid helium bath The electronics portion consists of the Tristan three channel iMAG model iMC 303 SQUID controller and Flux Locked Loops FLLs There is a liquid helium level meter and electronics with a computer interface The final piece of the electronics is the magnet power supply A block diagram view is shown in Figure 1 5 Port to Reservoir DUID Detection System Water Bag Patient Bed Figure 1 2 Water Bellows and SQUID Detection System The dewar has a small diameter tail to more easily make pediatric measurements It is designed to have a one week operational time between refills of liquid helium Typical spacing tail gap between the cryogenic environment and room temperature for the model is 1 8 cm 1 4 The Water Bellows and Controls Because the magnetic susceptibility
11. the locator loop is fixed on the adhesive electrode ring The patient is moved upwards by means of the bed s motor to some mm below the closest distance under the side laser control In order to enable the measurement without the waterbag system use do a CNTRL A on this screen A check indicates that the water bag will not be used The distance shown on this screen for the locator loop is relative to the coil location ET teres T aanne mmm KAG Figure 6 4 Input Screen and Locator Loops The horizontal position is now software controlled by the locator loop on the x y screen of the biomagnetometer monitor For the center position a final readjustment is usually necessary in both horizontal directions if this is more than 1 cm the patient has changed his position and the positioning procedure may be repeated For moving the patient to the closest distance under the water bag load later on it could be practical to keep in mind the respective bed s z position given by the position transducer After informing the patient about the next steps the bed is raised by 0 5 to 1 cm below the end cap of the dewar and the water bag ca 30 C is inflated with the center of the latex membrane touching the patient first thereby avoiding any air folds The bed is moved up again under software control on the central screen of the biomagnetometer monitor until the start position is reached with the following recommended
12. 0 0 551815 9 999695 0 0 0 552108 9 999695 0 0 0 553884 9 999695 0 8 0 557029 9 999695 0 O 0 552282 9 999695 0 0 0 551768 9 999695 0 0 0 551541 9 999695 0 0 0 551781 9 999695 0 0 0 552162 23 999695 0 D 0 551743 9 999695 0 O 03552346 3299969556 0 0 551464 9 999695 0 0 0 551417 9 999695 0 0 0 551649 9 999695 D O 0 551796 9 999695 0 0 0 551410 9 999695 0 0 0 551485 9 999695 0 0 0 552914 9 999695 0 00 9 0 00 5 0 550431 999695 4 4 4 PT 0 000 4 888 0 002 LIVER 0 000 0 000 HEMISPHERE 12 000 HEMISPHERE 12 000 0 001 0 001 LLA LLB LLC 054701 0 000979 0 081413 090732 0 001170 0 110657 112288 0 001047 0 020324 116153 0 001211 0 020324 116152 0 001109 0 020324 119656 0 001048 0 020324 118808 0 000860 0 020324 116523 0 001108 0 020324 119715 0 001704 0 020324 120235 0 001168 0 020324 121603 0 001272 0 020324 122410 0 002254 0 020324 123458 0 000135 0 020324 124171 0 000922 0 020324 124897 0 001212 0 020324 125401 0 001156 0 020324 126529 0 001147 0 020324 126317 0 001122 0 020324 126467 0 001243 0 020324 127188 0 001080 0 020324 127836 0 001256 0 020324 128054 0 001173 0 020324 129043 0 001046 0 020324 129024 0 001122 0 020324 129178 0 001168 0 020324 129138 0 001080 0 020324 129328 0 001233 0 020324 129441 0 001052 0 020324 129680 0 001013 0 020324 129324 0 001082 0 020324 129847 0 001157 0 020324 129452 0 001150 0 020324 129494 0 001169 0 020324
13. 0 002879 0 000873 0 000765 8 054977 0 271751 0 001211 0 014555 0 000494 8 053912 8 053868 8 050557 8 044395 2 000561 231935 0 269786 0 003165 0 001088 0 000593 8 095017 0 273176 0 000439 0 014915 0 000285 8 093371 8 092926 8 089625 8 081929 1 959318 279154 0 269498 0 002896 0 000932 0 000451 8 135564 0 273044 0 000140 0 011171 0 000183 8 135571 8 134478 8 131569 8 128454 1 969537 314160 0 269729 0 003193 0 001281 0 000722 8 175121 0 272510 0 000191 0 010905 0 000069 8 175969 8 174793 8 172227 8 173163 2 019269 354913 0 269798 0 003164 0 001005 0 000483 8 214590 0 272455 0 000299 0 012018 0 000198 8 215527 8 214878 8 212186 8 211863 2 085936 394847 0 269776 0 003132 0 001120 0 000573 8 254711 0 272827 0 000161 0 010953 0 000157 8 254148 8 253976 8 250757 8 246340 2 073336 433234 0 269736 0 003179 0 001364 0 000758 8 294693 0 273556 0 000267 0 011223 0 000158 8 293265 8 293008 8 289535 8 281975 2 028823 469937 0 269759 0 003096 0 001183 0 000767 8 334096 0 273228 0 000179 0 009978 0 000148 8 333532 8 332720 8 329593 8 323708 2 015918 502310 0 269872 0 003260 0 001345 0 000432 8 373788 0 272770 0 000075 0 008835 0 000125 8 374680 8 373453 8 370825 8 369170 2 043922 534732 0 269641 0 002860 0 001302 0 000459 8 413459 0 272021 0 000047 0 010159 0 000206 8 414742 8 413764 8 411229 8 411644 2 117241 571328 0 269945 0 003037 0 001181 0 000468 8 453177 0 273508 0 000132 0 009972 0 000164 8 453451 8 453041 8 449986 8 448506 2 137439 010361 0 187333 0 002866 0 0
14. 0 267193 0 002835 0 000324 0 000634 3 803737 0 264875 0 000113 0 003709 0 000109 3 803068 3 802874 3 800332 3 796736 0 878758 139771 0 267560 0 002875 0 000423 0 000694 3 843225 0 264470 0 000166 0 004144 0 000070 3 841915 3 841651 3 838981 3 833005 0 836657 157306 0 267413 0 002957 0 000635 0 000582 3 882667 0 264521 0 000029 0 006509 0 000059 3 882087 3 881253 3 878964 3 874215 0 816667 183109 0 267529 0 002873 0 000785 0 000258 3 921772 0 265970 0 000043 0 008098 0 000064 3 922581 3 921336 3 919565 3 918714 0 859718 210470 0 267421 0 002887 0 000559 0 000405 3 960695 0 265476 0 000058 0 007119 0 000053 3 962045 3 960974 3 959131 3 960644 0 909631 227908 0 267371 0 002835 0 000705 0 000574 4 000471 0 264856 0 000095 0 003243 0 000144 4 000545 4 000134 3 997819 3 996269 0 949584 241355 0 267178 0 002866 0 000696 0 000484 4 040716 0 264606 0 000083 0 004667 0 000167 4 039711 4 039557 4 036857 4 031032 0 919330 258084 0 267251 0 002998 0 000560 0 000704 4 080725 0 264472 0 000079 0 005193 0 000257 4 080266 4 079694 4 077124 4 070348 0 867236 273153 0 266915 0 002937 0 000542 0 000594 4 120627 0 264975 0 000084 0 002986 0 000190 4 121289 4 120069 4 118026 4 114355 0 884683 280836 0 267392 0 003027 0 000630 0 000557 4 160076 0 265126 0 000048 0 001877 0 000039 4 161347 4 160106 4 158237 4 158819 0 944530 287708 0 267223 0 002964 0 000694 0 000452 4 200374 0 265125 0 000127 0 001914 0 000068 4 201387 4 200770 4 198659 4 198896 1 01135
15. 003491 5 902038 0 083156 0 365147 0 388909 0 050263 5 900839 5 900590 5 897581 5 891633 1 399630 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 3 3 3 4 4 4 5 5 5 5 6 6 6 6 6 K H H 7 7 7 8 8 8 8 8 8 8 8 9 9 9 9 9 9 9 9 9 9 9 9 2 327250 0 124617 0 005134 0 008674 0 000775 5 941212 0 130224 0 030944 0 067004 0 004755 5 941341 5 940504 5 937939 5 935514 1 401325 251466 0 114558 0 002703 0 007354 0 000244 5 980980 0 116541 0 008179 0 070226 0 001275 5 981863 5 980896 5 978792 5 978878 1 458525 567683 0 118202 0 002759 0 006852 0 000506 6 020780 0 121215 0 002927 0 096083 0 000552 6 021306 6 020777 6 018464 6 019607 1 521226 983367 0 118598 0 002659 0 011399 0 000363 6 061339 0 121588 0 001112 0 149771 0 000211 6 060893 6 060967 6 058099 6 056139 1 520175 548771 0 119548 0 002759 0 011232 0 000223 6 101514 0 123971 0 000429 0 166422 0 000403 6 100449 6 100496 6 097470 6 091834 1 467695 097836 0 120948 0 002878 0 011228 0 000234 6 140472 0 124887 0 000172 0 153509 0 000264 6 140298 6 139840 6 137085 6 132016 1 435638 612285 0 121751 0 002695 0 010515 0 000338 6 180107 0 125558 0 000114 0 139906 0 000280 6 180420 6 179458 6 177225 6 175756 1 481060 056705 0 122688 0 002806 0 010251 0 000294 6 218615 0 126997 0 000111 0 119273 0 000228 6 219619 6 218855 6 216673 6 219473 1 548968 454910 0 123704 0 002946 0 010434 0 000307 6 258239 0 127561 0 000782 0 113426 0 000407 6 258722 6 258668 6 25610
16. 12V SF 12V SF 36V SF CTTEMP OS ETTEMP OS RATETEMP OS RESSBAG OS RESSAIR OS 5V OS 15V OS 15V OS 12V OS 12V OS 36V OS CTTEMP LWL CTTEMP UWL CTTEMP LAL CTTI z lt TO o LEI EJ prio LH UAL ETT P LWL ETTEMP UWL ETTEMP LAL ETTEMP UAL 38400 page 71 of 76 300 3000 512 100 200 100 10000 he Oo Om H UO och tase Meb E OO ONO OO DO O GO OO OO Ul OO DNS 450 O COU OO OO OO GAMM FR OH E dec Bat Gere E coe ae as oR Cae qe eer ech e o O O CN OD O GS GOO O 6 oo O e A O e e m 9 9 9 t o o t OO OG O O DO OO CC CC C Ss O IB ooooooooo O O CH OO O OO O O OO 9 CX c O 0 O NB Ooo CO On CH TOO UO OO O cc ba lt a O O C 00 PP OO O O o Oo SUS SO GS DOS CS OCS SOS OS O rw rw h rw h rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw rw AI C AI AI C AI C AI P AI P
17. 5 175080 5 174944 5 173130 5 174785 1 308618 121890 0 000248 0 000001 0 000044 5 205660 5 206162 5 203833 5 201247 1 319240 122876 0 000320 0 000001 0 000079 5 237832 5 238390 5 235834 5 229971 1 268956 123206 0 000207 0 000001 0 000320 5 272934 5 272865 5 270586 5 264435 1 238345 123092 0 000124 0 000001 0 000092 5 309181 5 308659 5 306795 5 305323 1 270702 123357 0 000170 0 000001 0 000198 5 346807 5 346462 5 344726 5 346285 1 342430 124364 0 000282 0 000001 0 000274 5 385043 5 385374 5 383284 5 383141 1 390174 124880 0 000045 0 000001 0 000099 5 423959 5 424521 5 421988 5 417802 1 335821 125218 0 000090 0 000001 0 000111 5 463112 5 463263 5 460725 5 453154 1 285032 125443 0 000105 0 000001 0 000028 5 503286 5 502918 5 500757 5 496096 1 308237 125213 0 000235 0 000001 0 000040 5 543522 5 543012 5 541232 5 541619 1 366582 124680 0 000120 0 000001 0 000122 5 583137 5 583137 5 581245 5 582582 1 428537 124668 0 000064 0 000001 0 000090 5 623306 5 623804 5 621435 5 618928 1 407894 125676 0 000045 0 000001 0 000079 5 662839 5 663345 5 660698 5 653454 1 366810 126331 0 000979 0 000001 0 000135 5 702930 5 702896 5 700475 5 694734 1 357899 125278 0 001374 0 000001 0 000107 5 743085 5 742574 5 740589 5 740078 1 377713 124544 0 000664 0 000001 0 000186 5 782949 5 782632 5 780897 5 782592 1 448060 page 49 of 76 0 0 0 750284 1 407732 1 343250 1 367118 1 361147 1 362810 1 362937 1 363605 1 363911 1 365104 1 364674 1 363294 1 3649
18. 6031 64 Ch 100 pin Callout ribbon AI SQUID A 3 4 A0 8 1 2 SQUID B 5 6 1 9 3 SQUID C 7 8 2 10 4 H20 9 10 3 11 Pressure 5 Z Position 11 12 4 12 6 Cardiac 13 14 5 13 7 X fluxgate 15 16 6 14 8 Y fluxgate 17 18 7 15 Model 5700 Biosusceptometer page 64 of 76 NI 6025 16Ch 9 Z fluxgate 51 52 16 24 10 Spare 53 54 17 25 11 LL current 55 56 18 26 12 Level Meter 57 58 19 27 13 Flow Meter 59 60 20 28 61 62 21 29 63 64 22 30 AO DI 23 20 DACO D2 23 21 DACI 23gd Dig In Out 24 100 pin S100 ribbon breakout AI None AO Motor 23 20 DACO 23gd Dig In Out Ground 8 H20 FILL 75 PB3 BED 73 PB4 SPEED HI MISC TOP 79 PB1 H20 77 PB2 EMPTY BED UP 83 PA7 MISC 81 PBO BOTTOM NEXT 87 PAS BED 85 PA6 DOWN 5 9 PA3 BACK 89 PA4 START 95 PAI RESET 93 PA2 7 98 Gd STOP 97 PAO Green 57 PC4 STROBE 1 STROBEO 61 PC2 black 33 DGND 5V 34 5V Motor 25 24gd DIOO Enable Model 5700 Biosusceptometer page 65 of 76 Motor Fault sense Motor Diode fault Bed Relay 24 Bed Relay 25 Power 33 DGND Power 35 5V PCI 2321 all 10pin connectors Com 1 iMAG Com 3 HP generator COM6 Water bag isolated or Rack COM 4 direct Table PC se
19. 638007 1 096627 347929 0 267052 0 002864 0 000687 0 000595 4 679137 0 264841 0 000206 0 000983 0 000143 4 679097 4 678903 4 676280 4 672489 1 079170 352127 0 267341 0 002805 0 000685 0 000428 4 719275 0 264130 0 000058 0 001344 0 000252 4 717839 4 717530 4 714682 4 707816 1 042862 357340 0 267302 0 002941 0 000627 0 000819 4 758711 0 264195 0 000101 0 001595 0 000107 4 758368 4 757500 4 754952 4 750974 1 025994 O0000000000000000000000000000000000000000000000 Model 5700 Biosusceptometer page 50 of 76 1 1 463419 0 361823 0 267447 0 002972 0 000747 0 000545 4 798418 0 265371 0 000181 0 000871 0 000078 4 799347 4 798172 4 796120 4 795553 1 064237 1 1 463383 0 364737 0 267371 0 003152 0 000801 0 000305 4 838557 0 265070 0 000152 0 001142 0 000094 4 839421 4 838522 4 836587 4 838276 1 132459 1 1 463554 0 368121 0 267208 0 002970 0 000816 0 000588 4 878009 0 265019 0 000071 0 000522 0 000040 4 877891 4 877551 4 875120 4 875216 1 145696 1 1 463815 0 369233 0 267035 0 002950 0 000709 0 000587 4 917957 0 264403 0 000145 0 000387 0 000083 4 917157 4 916940 4 914117 4 909215 1 113303 1 1 463872 0 369977 0 267284 0 003043 0 000657 0 000567 4 958853 0 264151 0 000108 0 000068 0 000059 4 957845 4 957242 4 954532 4 948360 1 072571 1 1 463957 0 370949 0 267304 0 003102 0 000713 0 000543 4 998851 0 264865 0 000076 0 000672 0 000077 4 998626 4 997463 4 995162 4 991970 1 088681 1 1 464102 0 372758 0 267396 0 003013 0 000753 0 000551 5 037
20. AI P AI P AI P AI P AI P AT P OKAY RI RI RI RI RI RI R R RATETEMP LWL RATETEMP UWL RATETEMP LAL RATETEMP UAL ESSBAG LWL ESSBAG UWL ESSBAG LAL ESSBAG UAL ESSAIR LWL ESSAIR UWL ESSAIR LAL ESSAIR UAL Figure 11 3 Status Command And VAR Model 5700 Biosusceptometer page 72 of 76 O EH CY C3 C ID CX SE n O ECH CH Tat ei H ELO CO OS XXX OO OO EN O O0 QOO ES C O OO EW rw rw LW TW EWS rw rw EW rw EW rw 11 3 SQUID Interface Connector Pinout O O 000 O O FACE VIEW Figure 11 4 iFL 301 Pigtail Connector Pinout Face View 1 HEAT SIGNAL SIGNAL Table 11 1 iFL 301 Pigtail Connector Pinout Face View Note The connector shell twisted pair shields and cable shield are grounded to the connector shell and a circuit board ground Model 5700 Biosusceptometer page 73 of 76 11 4 Dewar Interface Pin Connec tors INTERNAL 19 pin connector Mag INTERNAL WIRING Wire 8 mil Manganin for all leads 2X 008 wire used except Magnet Heater Spare Magnet Heater Spare 8 mil Phosphor Bronze LakeShore QL 32AWG 4X 008 wire used EXTERNAL 19 pin connector Spare Magnet Heater net Heater U Magnet Voltage Spare Magnet Heater not currently
21. Chipset Graphics Driver DC133 FSB133 FFBO0000h FFBFFFFFh System board extension for ACPI BIOS FFCO0000h FFFFFFFFh System board extension for ACPI BIOS kkkkkkkkkkkkkkkkkkkk DMA USAGE SUMMARY kkkkkkkkkkkkkkkkkkkk DMA Channel Usage Summary 02 Standard Floppy Disk Controller 04 Direct memory access controller Ck ck ckck ck ck ck ck ck ck kk kk kk kk MEMORY SUMMARY Ckck ck ck ck ck ck ck ck ck kk kk kk kk 640 KB Total Conventional Memory 129236 KB Total Extended Memory Ckck ck ck ck ck ck ck ck ck kk kk kk kk DISK DRIVE INFO kk ck ckck ck ck ck ck ck ck ck kk kk kk A Floppy Drive 3 5 1 44M 963 Cylinders 8 Heads 512 Bytes Sector 32 Sectors Track C Fixed Disk 9982624K Total 8140448K Free 1244 Cylinders 255 Heads 512 Bytes Sector 63 Sectors Track D CD ROM Drive ck ck ck ck ck ck ck ck ck ck ck ck ck ck kk kk SYSTEM DEVICE INFO Ck ck ck ck ck ck ck ck ck ck ck ck ck ck kk kk Class Data Acquisition Devices Device PCI 6031E Resources IRO 05 MEM FDFFD000h FDFFDFFFh MEM DFFC000h FDFFCFFFh Si Class Data Acguisition Devices Device PCI 6025E Resources IRQ 10 MEM FDFFF000h FDFFFFFFh MEM FDFFE000h FDFFEFFFh Class Ports COM amp LPT Device N I PCI 232 4 Isolated Communications Port COM8 Resources TROS 141 I O ECC8h ECCFh Class Ports COM amp LPT Device N I PCI 232 4 Isolated Communications Port COM7 Model 5700 Biosusceptometer page 68 of 76 Resources IRQ 1
22. Heater 1 4 TIC _ spade terminals Magnet Voltage ADDED EXTRA MAGNET DEWAR CABLE A2 19 PIN CABLE FOR DIAGNOSTICS ON 25 OCT 99 14 METERS a i 2047 Torino Liver Fe SIZE Date DWGNO 25 Oct 99 2047 E10b Tony Ewing SHEET 10F1 Figure 11 6 Dewar cable A2 Model 5700 Biosusceptometer page 75 of 76 INTERNAL 8 FEET Internal Heater C Resistance squip 1 HEATER 280 7 SQUID 2 HEATER 283 5 SQUID 3 HEATER 283 SPARE HEATER CABLE WIRE TYPE 24 AWG 10 CONDUCTOR SHIELDED CABLE B I SPARE HEATER INTERNAL WIRING Pair each encased in fiberglass tube grease after installation Ax WIRE 8 mil Manganin for all leads 2X 008 wire used Approx 8 feet 19 pin connector supplied by Precision Cryogenics EXTERNAL 14 meters gt ORANGE WHITE SQUID 1 HEATER C o BLACK Y 4 SQUID 2 HEATER S i a X SQUID 3 HEATER y A m BLUE B 5 A YELLOW VIOLET GRAY SPARE HEATER BROWN EEN SPARE HEATER DEWAR CABLE B 19 Pin 2047 Torino Liver Fe OVE RALL SIZE Date DWG NO EV 28 June 99 2047 E14 Tony Ewing SHEET 10F1 Figure 11 7 Dewar Cable B Model 5700 Biosusceptometer page 76 of 76
23. Make sure the BMD 35M dewar is empty of liquid nitrogen e For the initial transfer it is recommended that 100 liters of liquid helium be available e Verify the helium level in the storage dewar and the BMD 35M dewar e Open the transfer and vent ports at the top of probe e Set the AMI model 135 level detector toggle switch to UPDATE e Begin the helium transfer observing all standard cryogenic handling and safety procedures Unless otherwise directed by Tristan personnel do not shock warm dewar with liquid nitrogen or helium IMPROPER INTRODUCTION OF LIQUID NITROGEN OR HELIUM DIRECTLY INTO THE DEWAR MAY PERMANENTLY DAMAGE THE DEWAR AND WILL VOID THE WARRANTY Cool the dewar slowly Expected cooling time is on the order of six hours Observe transfer levels Note dewar capacity of the BMD 35M is 35 liters When the liquid helium level meter indicates gt 9096 prepare to stop the transfer In any case do not fill the dewar above 99 9 Plug transfer and vent ports after allowing sufficient vent time Verify all connectors at top of probe are free from moisture Figure 3 1 shows the internal temperatures of the dewar sensor assembly With liquid nitrogen precooling it takes approximately six hours to go from 80 K to 5 K e If liquid nitrogen precooling is not used the cooling time is significantly longer and more liquid helium will be required to cool the dewar sensor array from room temperature to 4 2 K In this situat
24. WTRB 20 SQUID A gain SO B RANGE LL WTRB 50 SQUID B gain SO C RANGE LL WTRB 50 SQUID C gain MIN DIST LL WTRB 1 8000 minimum distance for LL oem MAX DIST LL WTRB 11 000 POLYNOMIAL WTRB 5 WTRBAG WATER A Water bag WTRBAG WAT Water bag WTRBAG WATER C background vs water R B background vs water Gl Water bag background vs water SO A RANGE WTRB 20 SO B RANGE WTRB 50 SQ C RANGE WTRB 50 MIN DIST WTRB 1 8000 MAX DIST WTRB 11 000 POLYNOMIAL LL AIR 3 LL AIR A 0 000000 0 000000 LL AIR B 0 000000 0 000000 LL AIR C 0 000000 0 000000 SQ A RANGE LL AIR 20 SQ B RANGE LL AIR 50 SQ C RANGE LL AIR 50 MIN DIST LL AIR 1 8000 MAX DIST LL AIR 17 0000 AX 0 0 A AY 0 0 AZ 0 0 BX 0 0 B BY 0 0 B BZ 0 0 CX 0 0 EY 0 0 CZ 0 0 Figure 8 5 Sample Data File Sample data file SO A 0 000000 0 33634 4 96308 SO B 0 000000 0 33634 4 96308 SOC Locator loop background vs air 0 000000 0 046126 0 374707 1 123400 0 000000 Locator loop background vs air maximum distance for LL 5 th order polynome 1 z 0 000000 0 33634 4 96308 28 75376 68 74368 58 21238 28 75376 68 74368 58 21238 28 715376 68 74368 58 21238 SQUID A SQUID B gain SQUID C gain minimum distance maximum distance 3 rd order polynome gain cm 1 z 0 000000 0 194607 0 662947 0 380440 0 000000 Locator loop background vs air SO A 0 000000 0 0137
25. be passed through and be inspected carefully for any bumps trapped magnetic flux from external sources breathing oscillations and far field perturbations Any visible or suspected perturbation has to be documented in the biomagnetometer logbook Assuming the traces are acceptable advance to the next screen Figure 6 10 E ee e Mesa a sen a e Ra DEE TARTE TES 13133 AW er DU B D ran Luc po OT 0 CE en o 1 MED 5 Geesse TE Figure 6 10 Measurement Results Panel Examine the values generated by the measurement If they are acceptable check the box to the left of the measurement Subseguent measurements will be inserted below the previous one Figure 6 11 If the measurement just made is unsatisfactory use the mouse to press the REDO button This erases the data of the measurement just taken and lets you repeat the measurement If you want to guit the measurement seguence press the ABORT button Now that you are ready to do the next measurement repeating the previous steps the motor driven bed is moved up again to the next starting position The bed position itself is usually slightly higher due to some deformation in the preceding run The horizontal position has to be controlled again and readjusted if necessary The total number of measurement runs depend on the precision to be reached on the quality of runs so far achieved and on the endurance of the patient A minimum of 3 runs of good quality vs the wat
26. chi thorax difference to water DI coil signal reading at start of measurements D2 coil signal reading at start of measurements DSOB DSQC FLX X FLX Y FLX Z CARD FREE 082409 0 140740 0 562063 0 020665 4 871118 4 855266 4 852904 4 840394 1 265223 104030 0 007376 2 319692 0 006995 4 891339 4 891994 4 889453 4 885103 1 218138 114203 0 000136 0 167116 0 004922 4 900467 4 900946 4 898636 4 891912 1 166362 113130 0 000068 0 007222 0 001055 4 910590 4 910422 4 908471 4 905562 1 139603 112992 0 000038 0 000312 0 000847 4 922241 4 921841 4 920274 4 922079 1 200010 113685 0 000171 0 000013 0 000823 4 935118 4 935260 4 933546 4 936298 1 257588 114343 0 000243 0 000001 0 001083 4 948296 4 948972 4 946782 4 944760 1 252045 115015 0 000147 0 000000 0 000508 4 963867 4 964500 4 962061 4 956536 1 198059 115933 0 000166 0 000000 0 000773 4 981789 4 981806 4 979573 4 975569 1 158184 116140 0 000187 0 000000 0 000262 5 000702 5 000318 4 998615 4 997703 1 198077 116722 0 000039 0 000000 0 000288 5 021095 5 020857 5 019292 5 021302 1 257374 117939 0 000052 0 000001 0 000371 5 041920 5 042297 5 040277 5 040589 1 280076 119514 0 000101 0 000001 0 000104 5 064328 5 065027 5 062523 5 058747 1 253299 120933 0 000180 0 000001 0 000433 5 090606 5 090982 5 088516 5 083230 1 205928 120651 0 000074 0 000001 0 000097 5 117168 5 116928 5 114973 5 111282 1 210891 120787 0 002132 0 000001 0 000399 5 145900 5 145404 5 143777 5 144817 1 258503 121650 0 002013 0 000001 0 000145
27. lifted into place into the gantry Model 5700 Biosusceptometer page 13 of 76 Figure 2 6 Dewar in Gantry 2 5 2 Installation of water bag See the separate documentation for the installation and filling of the water bag subsystem Figure 2 7 It is important to note that the air must be removed from all the lines for the system to function Small amounts of air will prevent the bag from rising Always used clean iron free distilled water p Sensor a Pa FU NI Figure 2 7 Water Bag assembly A block diagram of the water bag fill assembly is shown below This structure must be filled with water without leaks so that the entire assembly is hydraulic and not pneumatic All air must be removed The most effective technique is to bleed from the top points and to use the pump to flush water plus air through the system and that the air collects at the high points Model 5700 Biosusceptometer page 14 of 76 19 Rackmount FAN Zu SI Figure 2 8 Water bag flow schematic 2 5 3 Preparation of subject bed The patient bed may now be brought into position There is a strap which holds the top of the bed snug against the base this fastening is to prevent damage to the bed lifting mechanism duri
28. material and fill the rest of the container with Styrofoam or shredded paper The unit must be completely protected by at least 8 cm of packing material on all sides 4 The dewar must be shipped inverted Care must be taken not to damage any of the connectors on the dewar top Fig 2 6 If the dewar vacuum is poor the top plate center tubing and bottom plate including the tail section must be secured to avoid separation of the dewar sections or relative motion of any part of the dewar Failure to follow these directions will void any warranty 5 Damage indicators such as shock watches and tip N tells should be attached to the shipping crates 6 If you are unsure how to pack the items contact your local Tristan representative or Tristan directly 2 6 2 Return from Customers outside the U S To avoid delays in Customs clearance of equipment being returned contact the Tristan representative in your area or the Tristan factory in San Diego California for complete shipping information and necessary customs requirements Failure to do so can result in significant delays 3 Operation 3 1 Introduction The cryogenic system consists of a fiberglass fixed tail liquid helium dewar see Figure 2 5 containing three channels of SQUIDs and detection coils and an integral superconducting magnet 3 2 Initial Operation 3 2 1 Initial Cooldown e Inspect dewar and verify internal cavity is free from ice moisture or other contaminants C
29. on cable TC Magnet Heater 1 4 CC spade terminals Magnet Voltage BNC connector Male DEWAR CABLE A1 19 PIN 2047 Torino Liver Fe SIZE Date DWGNO EV 11 Aug 99 2047 E10a Tony Ewing SHEET 10F1 Figure 11 5 Dewar Cable A1 Model 5700 Biosusceptometer page 74 of 76 INTERNAL Pair each encased in fiberglass tube grease afler installation 8FEET x n Be n LI Si Diode vi D 19 pin connector Vis 2 D 12 Si Diode See diagram below v2 2 N24 iu kd D 13 Si Diode va 3 vss U LakeShore 4 lead wire encase in fiberglass tube grease after installation gt Spare Magnet Heater Magnet Heater fi Magnet Voltage BNC connector has shield on V4 INTERNAL WIRING Wire 8 mil Manganin for all leads 2X 008 wire used except Magnet Heater Spare SEE 1 I Magnet Heater Spare 8 mil Phosphor Bronze LakeShore QL 32AWG 4X 008 wire used A Ki 1 I lote see 1 LakeShore silicon i our lea diode lead i W Measurement Strachment i 1 instructions CS I EXTERNAL F 1 PA A E NEUE E 19 pin connector n m 6 LEMO 1 Au Vie p D AS PER LTC MANUAL i LEMO 2 v s L 13 ka LEMO 3 a N3 vas ve TC Magnet
30. open and current can be injected into the coil When the desired current and equivalent magnetic field is achieved the persistent switch heater is turned off and the switch cools down becoming superconducting The current then flows through the persistent switch section completing the circuit At this point the HP 6541A power supply can be turned off as the magnetic field current is trapped inside the coil The relaxation time after setting or changing a dc field can be as long as 4 to 6 hours Model 5700 Biosusceptometer page 18 of 76 To remove the field it is necessary to turn on the HP power supply and drive the current up to its previous value before opening the persistent switch To HP Power Supply To HP Power Supply Heater Heater on of E a gt Figure 3 2 Conceptual drawing of a persistent mode superconducting magnet The magnet power supply system has four heaters one for the persistent switch and three to heat each of the SQUID sensors and a high current Hewlett Packard model 6541A power supply The charge circuit is shown in Figure 4 3 Figure 3 3 Heater Switch Front Panel part of system control instrument rack The switch heater in Figure 4 2 is run normal by 1V 1V 500hms The SQUID input heaters SQ 1 SQ 2 SQ 3 in Figure 4 2 are also run normal by 1V A normal charge from 0 to Imax consist
31. volumes V from analysis of the video tapes total body iron stores Ur can be calculated according to Ure cg TT Vijver Cree Vipieen 0 8 eq 5 2 Fe Fe liver Fe spleen Further meaningful parameters such as total body iron elimination rates and rate constants chelation therapy efficacy can only be calculated and compared if the mentioned clinical data on the transfusion and chelation therapy regimen of each patient is available with sufficient precision For comparison in vivo liver iron concentrations by SQUID biomagnetic liver susceptometry are given in 1 g 2iver in contrast to in vitro LIC from biopsies in u2 8wet weight Or in Mg gary weight One may calculate 3 5 Ug gary weight 1 UZ Ewet weights by current experience with biopsies from thalassemics the theoretical factor of 3 5 is justified 8 System Software 8 1 Introduction Biosusceptometer Software Functionality and Flow Control The model 5700 Biosusceptometer system control data acquisition and analysis software is written in National Instruments LabWindows CVI development environment CVI is interactive graphical user interface development environment based on the C programming language for more information go to the National Instruments CVI manuals or www natinst com The biosusceptometer software functionality and flow control is sketched below Figure 8 1 When the program is started the software first reads the input files System Parameters and Mach
32. when cold The vacuum should hold for a long period of time a year or more 2 5 1 2 Placement of dewar in Gantry Figure 2 5 shows the cross section of the dewar The dewar belly has a volume of about 35 liters This structure should not be tipped when full Care must be taken to not freeze the O ring at the top of the dewar or the O rings at the connectors Care should be taken for the connectors for the SQUIDs in particular since they could collect cryogenic liquid during a transfer Make sure there is a safety mechanism for the lifting of the dewar separate safety straps and that there are multiple personnel spotters present when lifting the dewar A fall will destroy the dewar Damage to the dewar due to improper handling is not covered by the warranty or service contract Figure 2 5 Dewar cross section This dewar must be installed in the gantry box and then installed in the gantry The final assembly is shown below The preferred method is to install straps on the side of the dewar The dewar is lifted into the gantry box via the external straps and then placed on a rubber vibration isolation on the inside bottom of the gantry box If the straps do not interfere with the measurement process they may be left in place Otherwise the straps should be removed The gantry box may then be placed on an electric lift This structure is then
33. 00114 0 000587 3 312858 0 266901 0 376717 0 003900 0 069241 3 303013 3 292132 3 274676 3 274342 0 794405 017560 0 265074 0 003043 0 000162 0 000643 3 315706 0 265582 0 015570 0 001712 0 002654 3 314906 3 314709 3 312224 3 305323 0 714462 021642 0 268021 0 003200 0 000092 0 000601 3 323017 0 265513 0 001132 0 000426 0 000309 3 322765 3 321997 3 319859 3 314823 0 700156 021717 0 268829 0 002920 0 000227 0 000676 3 332522 0 266838 0 000797 0 000161 0 000179 3 333631 3 332544 3 330851 3 330952 0 715508 022452 0 269216 0 003148 0 000082 0 000677 3 343869 0 268126 0 000496 0 000618 0 000091 3 345937 3 345096 3 343536 3 344810 0 766187 025349 0 268811 0 003061 0 000168 0 000507 3 356462 0 266891 0 000136 0 001138 0 000173 3 356965 3 356701 3 354705 3 353315 0 793183 029479 0 268619 0 003256 0 000368 0 000804 3 370206 0 266029 0 000047 0 000952 0 000034 3 369904 3 369858 3 367349 3 362625 0 751270 030658 0 268463 0 003052 0 000066 0 000537 3 385992 0 265636 0 000212 0 000146 0 000078 3 385428 3 385058 3 382663 3 376378 0 713141 029837 0 268657 0 003152 0 000420 0 000845 3 402481 0 266593 0 000442 0 000205 0 000138 3 402799 3 401874 3 400046 3 397570 0 712313 033845 0 268498 0 002959 0 000150 0 000393 3 420662 0 266776 0 000547 0 002819 0 000132 3 422061 3 421000 3 419443 3 421013 0 756806 043069 0 268571 0 003037 0 000062 0 000770 3 439852 0 267039 0 000316 0 001763 0 000115 3 440999 3 440411 3 438588 3 440735 0 809795 054340 0 268211 0 0
34. 03045 0 001097 0 000110 3 462012 0 265712 0 000499 0 006706 0 000034 3 462063 3 461983 3 459632 3 457413 0 795378 081122 0 268025 0 003126 0 000284 0 000777 3 485724 0 265237 0 000141 0 006401 0 000131 3 484460 3 484343 3 481819 3 474454 0 748802 092853 0 267681 0 002405 0 000391 0 001186 3 510447 0 265205 0 000290 0 001478 0 000042 3 509772 3 509044 3 506867 3 502162 0 726198 096307 0 267736 0 003308 0 000344 0 000373 3 535546 0 265662 0 000035 0 000403 0 000040 3 536578 3 535362 3 533597 3 534363 0 753974 097721 0 267523 0 002870 0 000402 0 000428 3 562736 0 265879 0 000116 0 000916 0 000060 3 564250 3 563360 3 561684 3 564630 0 824756 101418 0 267505 0 002944 0 000323 0 000542 3 593004 0 265711 0 000232 0 000869 0 000056 3 593634 3 593381 3 591273 3 590855 0 841928 103129 0 267688 0 002784 0 000105 0 000421 3 625485 0 265391 0 000356 0 000356 0 000023 3 624500 3 624484 3 621904 3 616032 0 808680 105235 0 267592 0 003140 0 000044 0 000712 3 657934 0 264521 0 000345 0 000818 0 000039 3 656938 3 656422 3 653926 3 648409 0 761199 108110 0 267592 0 002900 0 000333 0 000608 3 691579 0 265104 0 000352 0 000934 0 000034 3 691823 3 690692 3 688653 3 686711 0 768435 111934 0 267243 0 003013 0 000254 0 000553 3 726396 0 265681 0 000232 0 001242 0 000142 3 727821 3 726700 3 725030 3 726455 0 843698 116802 0 267485 0 002908 0 000199 0 000493 3 764406 0 266002 0 000192 0 001578 0 000113 3 765901 3 765175 3 763253 3 764242 0 880555 125173
35. 066 0 264768 0 000060 0 000593 0 000125 5 437861 5 436691 5 434385 5 431535 1 208340 1 1 465095 0 382518 0 267246 0 002974 0 000884 0 000528 5 477837 0 265486 0 000075 0 000214 0 000164 5 478816 5 477502 5 475530 5 476239 1 258285 1 1 465266 0 383216 0 267394 0 002913 0 000627 0 000517 5 517874 0 265733 0 000069 0 000200 0 000175 5 518726 5 517921 5 515658 5 515300 1 313098 1 1 465665 0 383651 0 267220 0 003127 0 000635 0 000757 5 558548 0 264284 0 000099 0 000269 0 000146 5 557712 5 557396 5 554530 5 550426 1 305328 1 1 465581 0 385053 0 267521 0 002932 0 000874 0 000655 5 599312 0 264466 0 000078 0 000320 0 000143 5 598030 5 597623 5 594606 5 587465 1 250969 1 1 465774 0 385409 0 267386 0 003064 0 000795 0 000416 5 639494 0 264409 0 000099 0 000207 0 000060 5 638870 5 637822 5 635294 5 629353 1 235285 1 1 465425 0 386411 0 267501 0 002940 0 000754 0 000500 5 678840 0 265105 0 000180 0 000196 0 000073 5 679992 5 678538 5 676378 5 675487 1 271243 1 1 465311 0 386498 0 267133 0 002871 0 000933 0 000728 5 718241 0 264982 0 000062 0 000185 0 000082 5 719329 5 718179 5 716049 5 716234 1 348604 1 1 465469 0 387471 0 267337 0 003093 0 000803 0 000528 5 758153 0 264640 0 000064 0 000246 0 000130 5 758066 5 757669 5 755006 5 752791 1 383708 1 1 465592 0 388687 0 267101 0 002971 0 000975 0 000500 5 798209 0 264577 0 000019 0 000568 0 000200 5 797191 5 797027 5 794042 5 788181 1 336013 1 1 465851 0 390038 0 267298 0 002837 0 000804 0 000486 5 839
36. 08 1 365236 1 368130 1 365436 1 365012 1 365565 1 365952 1 366346 1 366337 1 366609 1 366737 1 368132 1 368362 1 368245 1 367473 1 367576 1 367719 1 368227 1 368145 1 367271 1 368269 1 368433 1 368810 1 368697 1 369131 1 368986 1 368885 1 369122 1 369030 1 369363 1 369247 1 369277 1 369242 1 369446 1 369468 1 369704 1 270241 0 369712 0 787546 1 560859 1 481702 1 509663 1 503067 1 504379 1 504342 1 504443 1 504437 1 504019 1 504039 1 503848 1 504008 1 504110 1 503815 1 019462 1 443886 1 462559 1 464830 1 465583 1 464825 1 464437 1 464259 1 464587 1 464070 1 463632 1 463600 1 462234 1 461758 1 461082 1 460840 1 461256 1 461049 1 460908 1 460971 1 460698 1 460769 1 460634 1 461232 1 461319 1 461404 1 461617 1 461460 1 461524 1 461381 1 461617 1 461537 1 461752 1 461995 1 462145 1 461865 1 461785 1 461777 1 462316 1 462672 1 462592 1 462427 1 462097 1 462360 1 462862 1 463403 1 463674 BABHBOBADADHADADHADADHADANHHADHADADHHHHHHHHHHHHHHHHOO COOCO0C000000000000000000000000000000000000000000000000000000000000 518260 9 897917 0 114473 0 006075 0 077670 0 001946 5 820528 0 096883 0 043878 0 251223 0 017602 5 821642 5 821760 5 819615 5 818461 1 464133 178669 3 411696 0 008370 0 002796 0 145836 0 000994 5 860789 0 042181 0 102486 2 961867 0 038876 5 859834 5 859769 5 856767 5 850897 1 408095 0 449481 0 029970 0 022240 0 040666 0
37. 1 Dell Monitor 1b model FPD 1701 FP analog Dell Monitor 2 model M991 National Instruments DAC card 1 model PCI 6023E in rack National Instruments DAC card 2 model PCI 6031E in rack National Instruments Isolated Serial card 1n rack Hewlett Packard Printer model Laserjet 1200 Knurr Desk model 0 302 803 4 Sensor System Tristan model BMD 35M liquid helium dewar American Magnetics model 135 liquid helium level sensor Tristan model 1FL 301 L flux locked loops 3 Tristan model LSQ 20M dc SQUID sensors 3 Lakeshore Silicon diode temperature sensors model DT 470 SD 13 3 Motorized Patient Bed Gantry Water bag system including pump and microprocessor controller in second rack Vacuum mattress including pump Locator loops Cross Plane lasers Transfer line Phantoms 2 3 Initial Inspection All Tristan instruments and equipment are carefully inspected and packaged at Tristan prior to shipment However if a unit is received mechanically damaged notify the carrier and the nearest Tristan representative or the factory in San Diego California Keep the shipping container and packing material for the carrier and insurance inspections Even if there is no apparent damage we recommend you keep all packing materials until the system is fully operational Model 5700 Biosusceptometer page 10 of 76 SHIELDS THESE SHIELDS ARE TAPED AND GREASED IN PLACE ONLY If the unit does not appear to be damaged but does not operate to specifications contact
38. 1 I O ECD8h ECDFh Class Ports COM amp LPT Device N I PCI 232 4 Isolated Communications Port COM6 Resources IRQ 11 I O ECE8h ECEFh Class Ports COM amp LPT Device N I PCI 232 4 Isolated Communications Port COM5 Resources IRQ 11 I O ECF8h ECFFh Class Ports COM amp LPT Device ECP Printer Port LPT1 Resources IRQ 07 I O 0378h 037Fh I O 0778h 077Fh 11 2 Water Bag Microcontroller WBC To start the microcontroller from a secondary terminal use 38400 8 1 n n and no caching On wake give the command start or programming for upload and then the program number The normal commands shown in Figure 11 2 then apply Procomm Plus Terminal File Edi View Options Data Tools Window Help Rapid Connect Data Script File R E Data y startup N ri SSS a a a CS in program a ER 0 003 Nov 19 2001 ion 0 003 Nov 19 2001 23 2 RTER 0 003 Nov 19 2001 Ak Host Chat Logoriwiz Winkink Cmd Mode Send Fax Explorer ze VT 00 Xmodem drectconnectCom amp 38400 N81 rd Q sd cd cts 142PM ista A 8 aj i Procomm Plus Terminal Figure 11 1 Water Bag Setup Screen WBC STARTER Model 5700 Biosusceptometer page 69 of 76 Procomm Plus Terminal BEE File Edit View Options Data Tools Window Help Rapid Connect Data Script File E Data w STAR Y TER 0 003 Nov 19 2001 n 0 003 Nov 19 2001 23 21 16 Y Ate Host Chat L
39. 13 0 609183 1 331730 0 000000 SO B soc SQUID A gain SQUID B gain SQUID C gain minimum distance for LL maximum distance for LL cm Fluxgate X coefficient for SQUID Fluxgate Y coefficient for SQUID A Fluxgate Z coefficient for SQUID A Fluxgate X coefficient for SQUID Fluxgate Y coefficient for SQUID Fluxgate Z coefficient for SQUID B Fluxgate X coefficient for SQUID C Fluxgate Y coefficient for SQUID C Fluxgate Z coefficient for SQUID C CPU Date DateTime Thu Dec 16 16 48 02 1999 Last Name Bed G20 First Name drop Model 5700 Biosusceptometer Ur Ur ur page 48 of 76 Visit Number Date of Birth Sex Patient ID Weight Height TBF Comuthal ID Nrun Ndatapts Nchan MACHPARyy SYSPARmmyy FREE RangeA RangeB RangeC Distsel Zclose Ptvclose LLcur FREE Organ Orgdist Orgerr Orgg Ael or Rorg Bel Cel Torg Tael or Rtor Tbel 1 10 10 2000 MALE 1 0 000 0 000 6 MACHPARyy asc SYSPARmmyy asc 552186 999695 Tcel Dchitor D1 D2 FREE FREE FREE FREE FREE FREE FREE FREE FREE FREE FREE RUN SQA SOB SQC 0 0 380339 0 503267 0 0 0 543428 6 385418 0 0 0 551765 9 801740 0 0 0 551564 9 991140 0 00 551337 8 898325 0 0 0 551771 9 998679 0 0 0 551564 9 999694 0 0 0 551589 9 999695 0 0 0 551448 9 999695 0 0 0 551496 9 999695 0 0 0 551854 9 999695 0 0 0 551806 9 999695 0 0 0 551500 9 999695 0
40. 152 0 264446 0 000162 0 000106 0 000141 5 838242 5 837504 5 834716 5 828002 1 282569 1 1 465760 0 390629 0 267285 0 003018 0 000689 0 000628 5 879159 0 264550 0 000185 0 000298 0 000166 5 879959 5 878636 5 876238 5 873306 1 292733 1 1 465502 0 390942 0 267466 0 003014 0 000904 0 000425 5 918212 0 264628 0 000134 0 000106 0 000162 5 919195 5 917868 5 915695 5 915240 1 372972 1 1 465929 0 392534 0 267130 0 002950 0 000619 0 000466 5 957995 0 264945 0 000152 0 000718 0 000122 5 958267 5 957507 5 955132 5 955110 1 429505 1 1 465362 0 394021 0 267282 0 002945 0 000732 0 000386 5 998742 0 264734 0 000129 0 000383 0 000218 5 998867 5 998562 5 995755 5 991795 1 399017 1 1 465741 0 395630 0 267071 0 002990 0 000892 0 000553 6 039114 0 264510 0 000063 0 000309 0 000208 6 038118 6 037695 6 034709 6 027135 1 351470 1 1 465482 0 395959 0 267012 0 003018 0 000790 0 000493 6 079103 0 263552 0 000122 0 000253 0 000190 6 079099 6 078141 6 075444 6 070418 1 342429 1 1 464797 0 397339 0 267125 0 003011 0 000814 0 000612 6 117856 0 264500 0 000179 0 000359 0 000163 6 117998 6 116685 6 114402 6 113797 1 390267 1 1 465117 0 398088 0 266860 0 002982 0 000837 0 000514 6 157015 0 264471 0 000218 0 000303 0 000164 6 158268 6 157233 6 155035 6 157245 1 448725 1 1 465032 0 399297 0 267143 0 002995 0 000834 0 000470 6 197322 0 265103 0 000152 0 000286 0 000150 6 197625 6 197129 6 194576 6 193140 1 460150 1 1 465284 0 400967 0 266967 0 002877 0 000814 0 000441 6 236
41. 24 x 768 resolution and Hewlett Packard Color DeskJet Printer reside on the top of the desk The first rack houses the computer and most of the electronics and is EMC shielded The computer system includes an IBM compatible computer 400 MHz Pentium microprocessor 6 GB hard disk CD ROM Drive 17 color monitor with a second flat panel display for use during the measurement process The computer also contains National Instruments data acquisition cards RS 232 communication ports a Centronics compatible parallel port Windows 98 Operating System National Instruments LabWindows CVI Development Software The electronics housed in the rack are described in 2 2 The second electronics rack houses the water bag electronics 1 8 3 A second flat panel display for use during the measurement process should be located near the patient bed or mounted on the gantry A second off line computer is supplied for off line post processing This system can be used for final data analysis This computer has the ability to share files via either networking or via superdrive format 1 9 Schematic The system block diagram is shown below It consists of many integrated subsystems described earlier Model 5700 Biosusceptometer page 6 of 76 System Schematic Data Analysis PC LHe level Meter J 2 Monitor SQUID Controller Ch 2 T E
42. 313 0 002775 0 019443 0 000114 7 616800 0 141868 0 000089 0 028623 0 000246 7 615802 7 616151 7 613103 7 607276 1 877238 620556 0 135612 0 002720 0 019710 0 000205 7 656859 0 142447 0 000090 0 017044 0 000325 7 656357 7 656316 7 653338 7 648014 1 818910 675327 0 135585 0 002799 0 019581 0 000327 7 696744 0 141720 0 000026 0 017079 0 000405 7 697376 7 696711 7 694307 7 691313 1 816479 729719 0 135466 0 002630 0 019717 0 000291 7 735736 0 141086 0 000191 0 013903 0 000144 7 737266 7 736529 7 734426 7 735492 1 879454 777803 0 135797 0 002547 0 019930 0 000417 7 774943 0 141749 0 000148 0 014249 0 000095 7 775954 7 775628 7 773260 7 774251 1 941848 134794 0 123131 0 016081 0 114440 0 002250 7 815161 0 110940 0 123656 0 864704 0 016534 7 814958 7 815115 7 812154 7 809192 1 940909 452328 0 003832 0 004271 0 096587 0 000180 7 853628 0 035476 0 276879 2 237896 0 039812 7 852355 7 852022 7 848737 7 842336 1 843080 0 333600 0 107895 0 026887 0 027064 0 005736 7 896158 0 200736 0 422197 0 266591 0 089965 7 895100 7 894370 7 891364 7 885031 1 876978 160772 0 281260 0 006195 0 006380 0 001140 7 935651 0 290656 0 037378 0 053339 0 009050 7 935840 7 934687 7 932052 7 931216 1 936503 054611 0 264694 0 003301 0 002704 0 000682 7 974029 0 265733 0 009816 0 021937 0 002578 7 975050 7 974039 7 971456 7 973529 1 992938 137019 0 270584 0 003069 0 000609 0 000722 8 014803 0 274370 0 003335 0 014781 0 001306 8 014740 8 014406 8 011406 8 010160 2 040995 179173 0 269101
43. 330 4 locator loop frequency Hz Z LL Resistor 50 00 to measure voltage accross Ohm D1 LL VOLT 5i Dl locator loop source voltage V D1 LL FREQ 200 for 60 Hz power line D1 locator loop frequency Hz 240 Hz for 50 Hz power line Model 5700 Biosusceptometer page 45 of 76 D2 LL VOLT 5 0 D2 locator loop source voltage V D2 LL FREQ 250 for 60 Hz power line D2 locator loop frequency Hz 280 Hz for 50 Hz power line Constmag A 0 383 sensitivity constant SQUID A B 25 V mT cm Constmag B 2 0142 sensitivity constant SQUID B Pln 2 V mT cm Constmag C 2 6922 sensitivity constant SQUID C A 10 V mT cm Norconst A 1 0 normalization constant SQUID A SI unit V Norconst B 14 0 normalization constant SQUID B SI unit V Norconst C 140 normalization constant SQUID C SI unit V Range A 20 default SQUID A gain Range B 50 default SQUID B gain Range C 50 default SQUID C gain ultiply 500 A 0 040 multiplier for channel A gain 500 Multiply 500 B 0 100 multiplier for channel B gain 500 Multiply 500 C 0 100 multiplier for channel C gain 500 Multiply 200 A 0 100 multiplier for channel A gain 200 Multiply 200 B 0 250 multiplier for channel B gain 200 Multiply 200 C 0 250 multiplier for channel C gain 200 Multiply 100 A 0 200 multiplier for channel A gain 100 Multiply 100 B 0 500 multiplier for channel B gain 100 Multi
44. 5 amp Figure 2 7 TAIL IS VERY FRAGILE DO NOT REST IT ON THE TAIL SECTION The model 5700 is very sensitive of magnetic fields and magnetic contaminants The tail section of the dewar must be kept clean of contaminants Handle and store the dewar section accordingly The dewar sensor assembly is shipped upside down When removing the dewar sensor assembly from its crate first inspect it to ensure that it is still under vacuum If the bottom plate to which is attached the tail piece appears loose contact Tristan immediately Assuming that the bottom plate is firmly attached to the dewar belly i e the interior vacuum is good follow the following steps e Prepare wood blocks to rest the dewar top plate on Be sure that the top plate connectors will not rest on any of the blocks e Remove the dewar sensor assembly from its crate and rest it on the wood blocks e Remove the wooden sensor box from its crate e Prepare a temporary stand to rest the dewar on after it has been turned right side up The stand should be at least 50 cm above the floor to prevent the dewar from resting on its tail Model 5700 Biosusceptometer page 11 of 76 e Lift the dewar sensor assembly off the wood blocks and carefully tip it right side up The carefully rest it on the temporary dewar stand 2 5 1 2 will describe how to place the dewar in the sensor assembly box section of the gantry e Prepare a temporary stand to rest the wooden sensor assembly
45. 506 0 263731 0 000082 0 000108 0 000183 6 636422 6 635877 6 633159 6 631905 1 577487 1 1 464173 0 411587 0 266334 0 003038 0 000812 0 000579 6 677002 0 263442 0 000057 0 000558 0 000152 6 675976 6 675639 6 672551 6 666434 1 533244 1 1 463916 0 413402 0 266470 0 002883 0 000747 0 000598 6 717487 0 263366 0 000162 0 000296 0 000153 6 716494 6 715796 6 712829 6 705443 1 495114 1 1 464043 0 414516 0 266368 0 003041 0 001030 0 000551 6 757151 0 263060 0 000198 0 000437 0 000219 6 756761 6 755445 6 752888 6 750269 1 515175 1 1 463622 0 414770 0 266517 0 003038 0 000947 0 000607 6 796296 0 264222 0 000383 0 000225 0 000207 6 797133 6 795669 6 793373 6 795388 1 563465 1 1 463546 0 415596 0 266180 0 002944 0 000806 0 000715 6 836160 0 263902 0 000308 0 000582 0 000295 6 836991 6 836105 6 833699 6 833851 1 626014 1 1 463665 0 416562 0 266396 0 002755 0 000865 0 000490 6 876817 0 264050 0 000144 0 000195 0 000203 6 876662 6 876214 6 873339 6 868273 1 614583 8 3 Code required for a compile Below are presented the files required for the Biosusceptometer software To create a stand alone executable these files should be compiled inside the CVI development environment and the routine Create Distribution Kit should be completed see National Instruments manuals for LabWindows CVI for more details Model 5700 Biosusceptometer page 51 of 76 Srel A yem Figure 8 6 Code Compile List 8 4 Utility Screens Various useful utilities can be a
46. 608 0 264187 0 000232 0 000720 0 000106 6 235435 6 235186 6 232197 6 225281 1 435128 1 1 465299 0 402039 0 266953 0 002985 0 000772 0 000669 6 277417 0 263491 0 000175 0 000101 0 000113 6 276138 6 275394 6 272429 6 266335 1 390648 1 1 464771 0 402596 0 266726 0 002943 0 000765 0 000538 6 316434 0 264006 0 000073 0 000482 0 000050 6 316640 6 315380 6 312845 6 310750 1 400563 1 1 464673 0 403592 0 266966 0 002936 0 000777 0 000645 6 356070 0 264740 0 000051 0 000156 0 000077 6 357134 6 355830 6 353686 6 355047 1 466193 1 1 464543 0 405238 0 266594 0 002993 0 000870 0 000475 6 396024 0 264330 0 000079 0 000618 0 000105 6 396530 6 395754 6 393366 6 393655 1 513342 1 1 464512 0 405879 0 266864 0 002866 0 000800 0 000622 6 436940 0 264204 0 000272 0 000098 0 000096 6 436259 6 436054 6 433099 6 429299 1 518548 1 1 465111 0 406497 0 266776 0 002989 0 000834 0 000553 6 478093 0 264017 0 000161 0 000208 0 000166 6 476633 6 476188 6 473119 6 467379 1 456111 1 1 466093 0 407071 0 267208 0 003014 0 000845 0 000621 6 517458 0 264546 0 001099 0 000329 0 000153 6 517202 6 516109 6 513399 6 508536 1 431783 1 1 466042 0 408556 0 267143 0 003129 0 000893 0 000456 6 557232 0 264261 0 001290 0 000362 0 000127 6 557541 6 556075 6 553833 6 553190 1 484992 1 1 463453 0 409710 0 266603 0 003042 0 000730 0 000524 6 596747 0 263606 0 000189 0 000512 0 000294 6 597406 6 596199 6 593927 6 595817 1 543620 1 1 464050 0 411045 0 266282 0 002938 0 000754 0 000271 6 636
47. 7 294448 0 267199 0 002934 0 000538 0 000598 4 240364 0 264979 0 000067 0 002124 0 000082 4 240065 4 239930 4 237373 4 234099 0 995556 302291 0 267199 0 002758 0 000647 0 000613 4 280690 0 264111 0 000046 0 002131 0 000103 4 280322 4 279953 4 277261 4 270600 0 923326 308406 0 267024 0 002867 0 000664 0 000485 4 319509 0 264460 0 000138 0 001647 0 000037 4 319217 4 318215 4 315879 4 309179 0 920303 313214 0 267013 0 003064 0 000665 0 000801 4 359105 0 264870 0 000024 0 001008 0 000017 4 360156 4 358863 4 356863 4 355571 0 978858 317329 0 267085 0 002943 0 000678 0 000444 4 398174 0 265028 0 000071 0 001547 0 000055 4 399326 4 398350 4 396406 4 397867 1 040994 323031 0 267147 0 003007 0 000794 0 000641 4 438817 0 265456 0 000197 0 001472 0 000055 4 439484 4 439142 4 436816 4 435976 1 048916 326663 0 267196 0 002845 0 000706 0 000361 4 479137 0 264802 0 000024 0 000801 0 000063 4 478923 4 478809 4 476067 4 470259 1 001369 330267 0 267339 0 002829 0 000504 0 000598 4 519481 0 264518 0 000104 0 001297 0 000079 4 518592 4 518005 4 515379 4 507924 0 981259 335670 0 267160 0 002894 0 000675 0 000568 4 558805 0 264331 0 000028 0 001712 0 000029 4 558935 4 557788 4 555543 4 553329 0 997576 340039 0 267048 0 002950 0 000527 0 000631 4 598606 0 265183 0 000103 0 001035 0 000177 4 600180 4 598968 4 597076 4 598616 1 051346 344415 0 267089 0 002868 0 000735 0 000577 4 638925 0 265638 0 000136 0 001265 0 000198 4 639961 4 639315 4 637270 4
48. 7 6 256406 1 577217 838541 0 124435 0 002723 0 010724 0 000363 6 299118 0 128223 0 001072 0 105909 0 000032 6 298230 6 298544 6 295583 6 290369 1 548485 200272 0 124903 0 002791 0 011023 0 000326 6 339152 0 129908 0 000594 0 102053 0 000294 6 338373 6 338295 6 335392 6 329269 1 491310 528294 0 125654 0 002764 0 011091 0 000275 6 378957 0 130790 0 000180 0 088298 0 000123 6 378494 6 377714 6 375183 6 372276 1 503493 822398 0 126455 0 002863 0 011564 0 000332 6 418047 0 131367 0 000395 0 084127 0 000285 6 419008 6 418136 6 415958 6 418000 1 569839 131785 0 127639 0 002800 0 012403 0 000327 6 458325 0 131747 0 000690 0 093920 0 000369 6 459700 6 459341 6 457107 6 458146 1 628669 435441 0 127896 0 002645 0 012092 0 000317 6 499246 0 132306 0 000847 0 076579 0 000155 6 499101 6 499292 6 496573 6 492685 1 623553 674864 0 127844 0 002944 0 012620 0 000439 6 539457 0 133151 0 000233 0 067003 0 000087 6 538509 6 538605 6 535599 6 529503 1 562146 919578 0 128459 0 002880 0 013101 0 000220 6 579248 0 134075 0 000084 0 072292 0 000212 6 578794 6 578365 6 575547 6 570181 1 550813 154914 0 128909 0 002871 0 013468 0 000268 6 618083 0 134148 0 000222 0 063800 0 000079 6 618913 6 618081 6 615818 6 615031 1 595659 379245 0 129222 0 002751 0 013737 0 000169 6 657670 0 134099 0 000064 0 066712 0 000277 6 658759 6 658123 6 656005 6 657335 1 653598 612858 0 129932 0 002840 0 014124 0 000263 6 698083 0 134558 0 000111 0 067649 0 000034 6 698423 6 698352 6 695860 6 694
49. 718 1 688205 827501 0 130355 0 002678 0 014223 0 000333 6 738443 0 136202 0 000063 0 054014 0 000237 6 737792 6 737958 6 735006 6 729807 1 650712 998072 0 130665 0 002568 0 014880 0 000221 6 778510 0 136346 0 000131 0 048726 0 000057 6 778111 6 778008 6 775073 6 767403 1 618411 173333 0 131230 0 002745 0 014839 0 000309 6 818114 0 137036 0 000684 0 049224 0 000224 6 818552 6 817872 6 815402 6 811476 1 627107 324990 0 131378 0 002861 0 015386 0 000405 6 856847 0 136463 0 000234 0 041259 0 000058 6 858218 6 857343 6 855194 6 855844 1 667599 477675 0 131690 0 002773 0 015587 0 000342 6 896893 0 136781 0 000392 0 044998 0 000204 6 898150 6 897828 6 895518 6 896068 1 740154 623773 0 132023 0 002675 0 015759 0 000114 6 936994 0 137468 0 000078 0 041164 0 000115 6 936898 6 937115 6 934354 6 930670 1 737386 780162 0 132201 0 002782 0 016396 0 000239 6 977711 0 138336 0 000039 0 048702 0 000062 6 977067 6 977223 6 974241 6 966585 1 691505 947232 0 132506 0 002828 0 016499 0 000447 7 016873 0 138738 0 000153 0 045514 0 000121 7 016814 7 016359 7 013682 7 007817 1 666435 085264 0 132733 0 002747 0 016772 0 000478 7 056404 0 138242 0 000083 0 036485 0 000066 7 057545 7 056652 7 054377 7 053235 1 689216 212130 0 133071 0 002800 0 016864 0 000247 7 096462 0 138645 0 000063 0 036316 0 000071 7 097840 7 097256 7 095140 7 096189 1 772567 336168 0 133068 0 002765 0 017055 0 000375 7 136898 0 138249 0 000253 0 035394 0 000149 7 137939 7 137959 7 135416 7 134272 1 799117
50. 853 0 265300 0 000096 0 000298 0 000041 5 038643 5 037410 5 035421 5 037210 1 156687 1 1 464393 0 373791 0 267406 0 003090 0 000693 0 000609 5 078210 0 265298 0 000045 0 000271 0 000069 5 079055 5 078352 5 076128 5 077955 1 190279 1 1 464769 0 373911 0 267245 0 002849 0 000709 0 000506 5 118828 0 264959 0 000098 0 000133 0 000044 5 118871 5 118742 5 116006 5 112177 1 194950 1 1 464712 0 374968 0 267409 0 003012 0 000785 0 000322 5 159302 0 264461 0 000112 0 000263 0 000063 5 157882 5 157581 5 154700 5 147852 1 147324 1 1 464405 0 375444 0 267301 0 002975 0 000685 0 000698 5 199062 0 263985 0 000053 0 000442 0 000044 5 197694 5 196717 5 194107 5 189610 1 121987 1 1 464794 0 376960 0 267303 0 003039 0 000763 0 000378 5 238307 0 265027 0 000147 0 000187 0 000033 5 238891 5 237521 5 235424 5 235835 1 173017 1 1 464797 0 377213 0 267396 0 002887 0 000673 0 000402 5 277882 0 265558 0 000041 0 000504 0 000017 5 278984 5 277908 5 275910 5 277480 1 229135 1 1 465080 0 378911 0 267437 0 002970 0 000815 0 000582 5 318694 0 265640 0 000168 0 000198 0 000035 5 319202 5 318734 5 316285 5 313732 1 263176 1 1 465548 0 379475 0 267359 0 003076 0 000755 0 000572 5 359406 0 264576 0 000107 0 000312 0 000151 5 358713 5 358422 5 355418 5 349372 1 219316 1 1 465201 0 380037 0 267641 0 002901 0 000876 0 000618 5 399153 0 263541 0 000052 0 000044 0 000151 5 397803 5 397123 5 394198 5 388255 1 181155 1 1 465422 0 380956 0 267326 0 002916 0 000847 0 000620 5 438
51. IUM IS NOT LIFE SUPPORTING Extreme Cold Cover Eyes and Exposed Skin Accidental contact of liquid helium or the cold gas that results from its rapid evaporation may cause a freezing injury similar to a burn Protect your eyes and cover the skin where the possibility of contact exists Eye protection should always be worn when transferring liquid helium Keep Air and Other Gases Away from Liquid Helium The low temperature of liquid helium or cold gaseous helium can solidify another gas Solidified gasses and liquid particularly solidified air can plug pressure relief passages and foul relief valves Plugged passages are hazardous because of the continual need to vent the helium gas that evolves as the liquid continuously evaporates Therefore always store and handle liquid helium under positive pressure and in closed systems to prevent the infiltration and solidification of air or other gases Do not permit condensed air on transfer tubes to run down into the container opening Keep Exterior Surfaces Clean to Prevent Combustion Atmospheric air will condense on exposed helium cooled piping Nitrogen having a lower boiling point than oxygen will evaporate first from condensed air leaving an oxygen enriched liquid that may drip or flow to nearby surfaces Areas and surfaces upon which oxygen enriched liquid can form or come in contact with must be cleaned to oxygen clean standards to prevent possible ignition of grease oil or other combustible s
52. LINE SHOULD BE ASSUMED TO BE A 30 CM 12 DIAMETER SPHERE LOCATED AT THE BOTTOM OF THE DEWAR TAIL NO PERSONS WITH PACEMAKERS CAN BE ALLOWED WITHIN THIS REGION We recommend that you indicate this region on the floor below the gantry Depending on the location patients with metal implants may not be able to be measured with this system While it may not be a safety issue the presence of metallic implants can interfere with the measurement process Ferromagnetic objects should not be brought into proximity of the tail while the magnet is charged Allowing ferromagnetic objects to be pulled into the dewar tail could break the water bag bellows or damage the dewar tail The superconducting magnet must be kept at liquid helium temperatures while it is charged If the dewar is warmed up without removing the field from the magnet it will cause the magnet to go normal no longer remain superconducting and liberate its stored energy guench While the energy liberated less than a few joules is small and in no way would cause overpressurization of the dewar this may damage the magnet s windings and will void any warranty or service contract 9 5 Other items to be guarded against To prevent interruption of service an uninteruptable power supply UPS could be implemented Tristan can not be held responsible for damage or injury incurred during a power failure To prevent ground loops a single isolation transformer where system power can be dr
53. Operating Guide for Model 5700 3 Channel SQUID BioSusceptometer System By TRISTAN TECHNOLOGIES Inc San Diego California USA O copyright 2002 CAUTION Investigational Device Limited to investigational use only Model 5700 Biosusceptometer page i of 76 January 5 2000 Initial Release February 1 2000 Preliminary Release February 11 2002 Oakland 2000 2 by Tristan Technologies All rights reserved No part of this manual may be reproduced stored in a retrieval system or transmitted in any form or by any means electronic mechanical photocopying recording or otherwise without prior written permission of TRISTAN TECHNOLOGIES Inc TRISTAN TECHNOLOGIES Inc reserves the right to change the functions features or specifications of its products at any time without notice Any questions or comments in regard to this product and other products from Tristan Technologies Inc please contact Tristan Technologies Inc 6 Suite 10 San Diego CA 92121 U S A Technical Support 858 550 2700 Fax 858 550 2799 info tristantech com www tristantech com Model 5700 Biosusceptometer page ii of 76 WARRANTY TRISTAN TECHNOLOGTES Limited Warranty TRISTAN TECHNOLOGIES Inc warrants this product for a period of twelve 12 months from date of original shipment to the customer Any part found to be defective in material or workmanship during the warranty period will be repaired or repla
54. Plot measure Vvst HHC Bed Test Squid G Run LL SQUID Calibrate locator loop Backgnd Subtract Galib Figure 8 1 Software Schematic 8 2 Software File Structure All input and output files are ASCII files The model 5700 Biosusceptometer system is delivered with the input files containing the factory calibration parameters and hardware setting values Model 5700 Biosusceptometer page 44 of 76 The user is reguired to recalibrate the system on site charge the magnet set appropriate hardware values and then manually edit the input files using a text editor like NotePad and save files with appropriate names MACHPARyy asc and SYSPARmmyy asc Place the newly created file names in the SYSDAT FF asc file Never change the format of the input files It will result in system errors On software wake up the SYSDAT FF asc file is read and the stored file names are used as Machine and System parameter files In addition the SYSDAT FF asc file contains information on the liquid helium level Presented below are examples of required input files and an example of the output file The output file header consists of patient information machine and system parameters Measurements for one patient measurements run and the Patient file correspondingly can have up to 20 runs each run consists of 100 or 160 po
55. S 64 LOS Nie ham al k r p Maintenance Ee enen 64 10 6 Transfer Tube Maintenance ini iet a ee de ce dea i d a prine 64 Ll ee nissan E m 64 11 1 Hardware PC and National cards SUP 64 11 2 Water Bag Microcontroller WBC acesa A qa Ta 69 11 3 SQUID Interface Connector Pinout ee 73 11 4 Dewar Interface Pin Connectors iiie er er D raider iaa 74 Table of Figures Figure 1 1 System dewar gantry bed and electronics photo 1 Figure 1 2 Water Bellows and SQUID Detection System eres 2 Figure 1 3 Gradiometer Double D Coils Figure 1 4 SQUID vs Position for Loop 3 Figure 1 5 System Schematic oiec saya io 7 e EE E ed 8 Irgurc 2 2 0005 Bea aa OS dead eed te adele ocala dh epus 8 Figure 2 5 Room Lay Ou ss siyas itii e retener tin ROREM TE EX UAM sl ad NEN dde 9 Lig re 2 4 Gantry Ga m ds td lal 12 Pisto 2 5 DEW EOS OO ees 13 Eigure 226 DA E 14 Bistire 2 7 Water Bag ASS iege alet nil G mme e tera os sal doin 14 Figure 2 8 Water bag flow schematic eee eet tener ssd bana ila deed eS ERE aen seeds 15 Ligure Bed ssembl yoran sa a lame ll Mio ieu auos enc aca ima i eub ie 15 Figure 3 1 Dewar Initial Cooling EE 18 Model 5700 Biosusceptometer page vi of 76 Figure 3 2 Conceptual drawing of a persistent mode superconducting magnet 19 Figure 3 3 Heater Switch Front Panel part of system control instrument rack 19 Figure 3 5 Hand Held Co
56. T shirt slip and socks may be left on 6 2 4 Data needed directly prior to the measurement The patient s name birth date principle diagnosis date of splenectomy height weight sex and health care center is documented in the biomagnetometer logbook and on the biomagnetometer measurement report Height weight and total body fat impedance measurement by TANITA body fat monitor scale mod TBF 531 are measured instantaneously and entered via the subject data screen Figure 6 2 If the patient measurement is conducted via the position transducer the Closest Distance for the Position Transducer is cm relative to the dewar face After entering the patient information enter the file name to be used for the measurement DO NOT MOVE THE BED OR WATER BAG DURING THE FILE NAMING E e ral 6 2 5 Positioning of the patient After undressing the patient is placed in supine position with the right side turned upwards on an evacuatable cushion of the biomagnetometer bed The bed should be placed with its wheels Model 5700 Biosusceptometer page 33 of 76 placed on pre positioned marks on the floor For female patients with a full chest this position should be turned more to the left the right arm may be laid around the head and with the hip position less prominent These efforts result in an outstretched and horizontal thorax position with a maximum organ volume on top Optimum positioning can be facilitated by aid of small pillows espec
57. UID amp FluxGate chan data Band Stop Filter Lower Cutoff Frequency BSF UC Freq 65 0 SQUID amp FluxGate chan data Band Stop Filter Upper Cutoff Frequency Model 5700 Biosusceptometer page 46 of 76 BSF Center Freg 60 0 Center Freguency SQUID amp FluxGate chan data Band Stop Filter 0 S W Lock In 1 H W Lock In 0 Torino 1 Oakland WBC Firmware Version to run Oakland WBC Oakland WBC Oakland WBC Oakland WBC Oakland WBC Oakland WBC Oakland WBC Oakland WBC controlling 10ms controlling loop in Volts k LockInType 0 WaterBagModel 1 WBCFirmwareVer 2 021 WBCtimeintvall 4 0 seconds WBCvalvevaluel 0 2 Timeintvall in volts WBCtimetotal 10 0 seconds WBCvalvevalue2 0 1 Timeintval2 in volts WBCvalvestart 0 63 volts WBCvalverest 1 26 volts WBCKp 0 02 controlling in Volts kg WBCKi 0 0005 WBCstoptime 240 digital valve after stop in seconds WBCPrslp 2 876 in kg Volts WBClprs 3 087 IMAGCOMPort 5 HPWaveformCOMPort 2 WaterBagCOMPort 6 free Figure 8 4 SYSPARmmyy asc SYSPAROO O asc Oakland WBC Oakland WBC Oakland WBC Time interval of bed ramp in Change of valve amplitude in Total measurement time in Change of valve amplitude in Valve amplitude at start in Valve amplitude at rest in Proportional factor of P Integral factor of I g Time interval for opening the Pressure transducer coefficient Pressure intercept kg in
58. agnetic interference Examples include power distribution panels autoclaves telephone switching equipment and cellular base stations The model 5700 biosusceptometer can detect signals as small as 10 P tesla Because of this attention must be paid to external noise sources The goal of a site survey is to determine the optimum site to place an instrument Hospitals and other facilities in urban environments can be extremely noisy due to electromagnetic radiation rfi low frequency magnetic noise and noise at intermediate frequencies contributed by machinery and power lines The use of gradient configuration detection coils in the model 5700 biosusceptometer can overcome much of this noise in a normal laboratory setting but greater noise reduction may be needed for routine clinical applications Environmental noise can be particularly severe at low frequencies A site survey prior to system installation must be performed to determine the ambient noise and the level of shielding required An extremely sensitive e g SQUID or flux gate magnetometer should be used for the site survey Tristan Technologies can not be responsible for substandard system performance if the model 5700 Model 5700 Biosusceptometer page 7 of 76 biosusceptometer is sited in a noisy environment If you need assistance in performing a site survey contact your local Tristan Representative Shown below are representative measurements of measurements made at a poor site Figur
59. air measurements are fitted by 3 order polynomials vs distance a polynomial made up from mean coefficients is subtracted from the SQUID voltages from water bag measurements and the radius of an assumed hemispherical or cylindrical thorax geometry is variated for minimum chi square G2 deviation from the known susceptibility difference AXwater air see above This effective radius would count for any deviation from the ideal spherical geometry and also for problems in positioning a patient in a proper horizontal way In small children these air runs may be performed at first in order to get the children used to the whole procedure 6 3 Data Storage organ volume estimation and on line analysis 6 3 1 Finalization of the measurement The data of the measurement runs will be stored finally on software command The filename is typically made up by the first 3 characters of the last and the first 3 characters of the first name patient Id no 5 digits number of visit 3 digits and an extension for the organ 3 characters e g Fagrob00299001 liv Duplicate filenames will not be allowed by the system s software check Thereafter the online analysis is performed after selecting suitable runs and is printed 2 times for the clinician s usage and for the documentation at the biosusceptometer facility When the measurement is finished the patient sits up After a rest of 10 20 seconds sitting upright on the bed the patient could be asked to dress a
60. akland Department of Hematology Oncology 747 52nd Street Oakland CA 94609 TEL 510 428 3058 FAX 510 450 5813 Estimate of Fe by SQUID Biomagnetic Liver Spleen Susceptometry For First Name Last Name Tue Feb 05 20 08 03 2002 DOB 10 10 2000 File c Patient Data lkasjdklaj liv Organ Type LIVER Weight kg 50 0 Height cm 170 0 BMI kg m 2 0 000 System Background LOCATOR LOOP AND H20 BAG VS H20 ORGAN Geometry HEMISPHERE Z organ cm 1 00 dz 0 03 Distance by LL ORGAN Dimensions HEMISPHERE radius cm 12 0 THORAX Geometry HORIZONTAL CYLINDER THORAX Dimensions HORIZONTAL CYLINDER radius cm 12 0 THORAX dX tis 10 6 0 000 Run No LIC A LIC B LIC C X 2 A X 2 B X 2 C H20 Pressure ug g org ug g org ug g org kg Model 5700 Biosusceptometer page 41 of 76 Mean of Runs SQUID A ug Fe g organ SQUID B ug Fe g organ SQUID C ug Fe g organ 0 0 0 0 0 0 ug Fe g organ Total Mean and Error 0 0 Figure 6 12 Subject Analysis Printout 7 Final analysis The final analysis will be done on the second data analysis computer under the Hamburg HP Basic routines 7 1 Simultaneous determination of iron concentration and tissue susceptibility An effective thorax geometry estimation has to be performed first Under ideal positioning conditions this is some kind of internal quality control i e the estimated effective cylindrical or hemispherical radius should be similar to
61. al directions are performed and from all four images the mean skin organ distance SD standard deviation is determined Finally a subcostal image is taken typically documenting the hepatic tissue appearance contrasting with the kidney tissue All sonographic positioning work should be recorded on video tape for later inspection in case of doubts about certain parameters After finalizing sonography the position is marked instantaneously by an adhesive electrode ring for taking up the locator loop at the measurement position A preliminary curvature of the thorax is assessed by aid of the novel thorax radius ruler tool Finally a Polaroid picture is taken from the position spot in comparison to typical body stigmata and the position of the arms at a close Model 5700 Biosusceptometer page 34 of 76 distance 0 6 m For reproducing this position in further measurements the position is cartooned by at least one distance to a body mark on the Polaroid picture Special care has to be undertaken to avoid any change of this position especially in children 6 2 7 Positioning of the patient under the biomagnetometer After the positioning and ultrasound procedure the bed is moved from its sonography position to the measurement position marked again on the floor After entering the patient information enter the file name to be used for the measurement DO NOT MOVE THE BED OR WATER BAG DURING THE FILE NAMING Before reaching this final bed position
62. ance determination by sonography mean error Az 0 5 mm 2 the erroneous knowledge or estimation if determined simultaneously from the measurement itself of the magnetic thorax tissue susceptibility mean error Ay 0 05 10 SD and 3 the standard deviation SD statistics from repeated measurements Model 5700 Biosusceptometer page 42 of 76 The relative error in repeated measurements in the same patient will be lower due to smaller systematic errors about Az 2 Ay gt 0 if the measurement position can be reproduced and the subject gained no weight Analyzing various patient measurements total errors SD total between 100 and 400 ug g were calculated from the squared sum of the 3 main contributions SD total ug g SD Az Cre SD Ay SD stat eq 5 1 Error functions for the systematic imprecisions Az and Ax have been parameterized with liver iron concentrations in the range of 100 12000 ug g and differential tissue susceptibilities between 0 2 10 SI and 0 5 10 SI The first contribution SD Az cr scales linearly by 3 5 with the liver iron concentration The second term is a parabolic function of the magnetic thorax tissue susceptibility Ax with an error minimum of SD Ax 100 ug g at Ax 0 SI and SD Ax 400 ug g at Ax 0 5 10 SI A 4 dimensional functional relationship SD z Ax Cre may prove to be beneficial 7 3 Total body iron stores and other related calculations After estimation of liver and spleen
63. ar dir eq 4 2 where X r is the magnetic susceptibility of the test object Bx r is the magnetizing field and Bari is the reciprocal flux density of the detector coil i e flux density generated by a current of Ig in the detector coil In our case Ba r is provided by a first order gradient field coil which is Model 5700 Biosusceptometer page 26 of 76 coaxial with the detector coil set The fields Bg and B are determined by the geometry of the coils which generate them and the response flux A amp can be calculated by numerical integration for a particular distribution of tissue of known susceptibility The field at off axis points values of Br were computed numerically The radial and axial components of the magnetic flux density produced by a simple circular loop of wire of radius r carrying a current I are given by the usual equations involving elliptic integrals The detector coil reciprocal field Ba was found simply by summing the contribution of each individual turn The voltage response of the SQUID detector is directly proportional to the flux change through the detection coil For a homogeneous object with cylindrical symmetry the integral Ba q z Bi q z q dqdz eq 4 3 carried out over the volume of the test object is proportional to the magnetometer response This function which we call the flux integral was calculated numerically using a parabolic approximation to the field integrals The q and z ranges were each divided
64. atural Keyboard System speaker System board extension for ACPI BIOS Standard 101 102 Key or Microsoft Natural Keyboard System board extension for ACPI BIOS System CMOS real time clock Direct memory access controller Programmable interrupt controller Direct memory access controller System board extension for ACPI B Numeric data processor ntel r 82801AA Ultra ATA Controller Secondary IDE controller dual fifo Primary IDE controller dual fifo ntel r 82801AA Ultra ATA Control Communications Port COM2 Secondary IDE controller dual fifo ntel r 82801AA Ultra ATA Controller ECP Printer Port LPT1 ntel R 810e Chipset Graphics Driver ntel R 810e Chipset Graphics Driver Standard Floppy Disk Controller Primary IDE controller dual fifo ntel r 82801AA Ultra ATA Controller Standard Floppy Disk Controller Communications Port COM1 Programmable interrupt controller ECP Printer Port LPT1 System board extension for ACPI BIOS System board extension for ACPI BIOS System board extension for ACPI BIOS OS ler 4 11 01 4 11 01 DC133 FSB133 DC133 FSB133 PCI bus Intel r 82801AA SMBus Controller Intel r 82801AA PCI Bridge XPERT 98 PCI English 3Com 3C920 Integrated Fast Ethernet Controller 3C905C TX Com N I PCI 232 4 Isolated Multi function Parent N I PCI 232 4 Isolated Communications Port COM8 N I PCI 232 4 Isolated Communications Port COM7 N I PCI 232 4 Isolated Mult
65. awn is recommended This does not include the water bag controller which should be on a separate power supply system Do not modify any part of the model 5700 biosusceptometer system Unauthorized modifications may damage the system interfere with its measurement capabilities or permit injury or death to occur Tristan will not be responsible for the misuse of this system The dual cross plane lasers used for positioning the patients are solid state laser diodes emitting light at 660 685 nm at a power of 0 5 mW Class II To avoid potential eye damage anyone using the system should not stare directly into the beams 10 Service and Maintenance 10 1 Inspection and Cleaning The most important feature in the care of the system is regularly filling the system with liquid helium This must be done to keep the magnet and the SQUID detection circuitry operational In addition to this the system must be kept magnetically clean near the tail region Always use gloves and special care in handling the tail and the rubber bellows 10 2 Cryogenic Dewar Maintenance 10 2 1 Vacuum In normal operation the dewar should not need pumping since the dewar has a cryopump inside The static pressure at the start should be 200 micron for 2 minutes Model 5700 Biosusceptometer page 63 of 76 10 2 2 Sensor Maintenance Water and ice must be kept off the sensor in order to have reliable readings If ice forms on the electrical connectors at the top of the dewa
66. box on This stand must have a 15 cm diameter hole in it and be at least 45 cm above the floor to prevent the dewar from resting on its tail A cutout in the side is preferable e Lift the dewar from its resting place on the temporary stand and set it in the wooden sensor box Be careful not to damage the dewar sensor tail If you are using rope to lift the dewar make sure that the rope s is firmly attached to the dewar section and is not directly attached to the tail 2 5 Preparation for use 2 5 1 Installation of Gantry Completely assemble the gantry except for the wooden dewar sensor support after the initial helium transfer the sensor is mounted in the wooden support and then the support is mounted to the gantry Take care to locate the gantry in its final position it is not an easy item to move Use the adjustable feet under the side support pillars to level the gantry After the Gantry piers are put in place mount the wooden dewar sensor box being careful not to damage the dewar tail The assembled gantry is shown below L L 4 sess ER ou
67. ccessed through the menu bar on the Main Panel Through the Hardware Test bar the user can access the following panels see below and test the following functionality SQUID outputs vs time all the measurements in this group are done using high speed data acquisition 10 kSamples sec and higher e io sel WEL mea Figure 8 7 SQUID Test Panel high frequency Lock in outputs vs time amplitude of SQUID A B and C on the frequency corresponding to the S Locator Loop set by the HP waveform generator Model 5700 Biosusceptometer page 52 of 76 er m Gm zi teer mmn re Figure 8 8 Locator Loop vs Time Position transducer voltage vs time er m Lem zz TS poseen m fri Figure 8 9 Position Transducer vs Time Water pressure voltage vs time al st 3v ye as AZ Figure 8 10 Water Pressure vs time Model 5700 Biosusceptometer page 53 of 76 Handheld controller test press on the handheld controller button should cause LED indicator on for the corresponding button on the software test panel Bol WE emmi gm Y Figure 8 11HHC Test Panel Bed Test allows to move the patient bed up down through the software panel interface and cycle the bed fully up and fully down Number of Cycles times el HE ei gem Figure 8 12 Bed Cycle Test Panel SQUID Controller panel allows to change the SQUID gains and to reset SQUIDs sl EV Dd Eege JI E Figure 8 13 SQUID Range T
68. ced without charge to the owner Prior to returning the instrument for repair authorization must be obtained from TRISTAN TECHNOLOGIES Inc or an authorized TRISTAN TECHNOLOGIES service agent All repairs will be warranted for only the unexpired portion of the original warranty plus the time between receipt of the instrument at TRISTAN TECHNOLOGIES and its return to the owner This warranty is limited to TRISTAN TECHNOLOGIES products that are purchased directly from TRISTAN TECHNOLOGIES its OEM suppliers or its authorized sales representatives It does not apply to damage caused by accident misuse fire flood or acts of God or from failure to properly install operate or maintain the product in accordance with the printed instructions provided This warranty does not cover any unauthorized modifications to the model 5700 biosusceptometer system Unauthorized modifications may damage the system interfere with its measurement capabilities and or permit injury or death to occur Tristan will not be responsible for misuse of this system This Warranty Is In Lieu Of Any Other Warranties Expressed Or Implied Including Merchantability Or Fitness For Purpose Which Are Expressly Excluded The Owner Agrees That TRISTAN TECHNOLOGIES Liability With Respect To This Product Shall Be As Set Forth In This Warranty And Incidental Or Consequential Damages Are Expressly Excluded Model 5700 Biosusceptometer page iii of 76 Table of Contents br
69. d so far e monitoring iron overload in patients with transfusional siderosis genetic B thalassemia major and sickle cell disease or other transfusion dependent anemias for the onset or intensification of chelation therapy and during this therapy e assessing iron overload in B thalassemics scheduled for bone marrow transplantation BMT or monitoring iron overload in ex 8 thalassemics after BMT scheduled for iron depletion therapy e assessment of iron overload in patients scheduled for interferon therapy in liver diseases assessment of the long term efficacy of different iron chelators under study e diagnosis of genetic hemochromatosis GHC and assessment of the degree of iron overload in known GHC e monitoring liver iron concentration in the initial and preservating phlebotomy therapy of GHC 5 1 2 What type of patients can be measured In principle nearly all kinds of patients between three and ninety years old with the ability to lie 30 minutes on a bed can be measured In practice there will be some difficulties with certain patients and some precautions have to be taken e patients with large ferromagnetic contaminants such as pacemakers or ferromagnetic dust in the lungs some welders can not be measured e measurements in patients with smaller magnetic contaminants such as dental clips stainless steel screws and nails in bones and joints can be corrected for this far field contribution e no influence has been observed from
70. deutete NEES dans aa askla adea ge 42 1 3 Total body iron stores and other related calculations eee 43 SNS e be QR UH Mbit dM Ee EE 43 8 1 Introduction Biosusceptometer Software Functionality and Flow Control 43 8 2 Software EE 44 8 3 Code required FOF a compiles lA e e RM ke 51 Sk Eeer EE 32 Model 5700 Biosusceptometer page v of 76 8 5 Utilities for Locator Loop and Background Susceptibility Calibration 56 5 5 T Calibrate Locator EE 56 8 5 2 Background Susceptibility Calibration annae enne ee enneerenneerenneerenvervenvervenn 58 8 5 3 SubtractonofTissucandlocatorsignal 59 99 4 Computation RE 60 UNE sica ISSUES MP rt D rem aT TE 60 9 1 Bed Motion sesimin dete e ede tn 60 92 Water e E n C E 61 9 37 Dewar Satety ne a A 61 9 3 1 H the flow indicator indicateslowflow lt 200SCCM 61 9 3 2 If the flow indicator indicates high flow gt 2000 SCCM 62 9 3 3 General comments about dewar safety enne s venne nv ennervennervennervenvereennen 62 9 4 Magnetic field EE 63 9 5 Other tems to Ee E EE 63 10 Service and Malta a 63 IO T Inspection and EEN 63 FIDE opene Dewar Maintenance smeed Ne dede eden 63 O akc asad RR RD O ERR RPPN RR PEER a IAS 63 10 22 Sensor Maintenance e E ai dai 64 10 3 B6d Maintenance eoi esa en nue ala e dia 64 ITA Mater BasMamenance ea nee en dee A S
71. device must be provided in that line to prevent excessive pressure build up Keep Equipment Area Well Ventilated Although helium is nontoxic it can cause asphyxiation in a confined area without adequate ventilation Any atmosphere which does not contain enough oxygen for breathing can cause dizziness unconsciousness or even death Helium being colorless odorless and tasteless cannot be detected by the human senses and will be inhaled normally as if it were air Without adequate ventilation the expanding helium can displace air and result in an atmosphere that is not life supporting The cloudy vapor that appears when liquid helium is exposed to the air is condensed moisture not the gas itself The issuing helium gas is invisible Liquid containers should be stored in large well ventilated areas If a person becomes groggy or loses consciousness when working around helium get them to a well ventilated area immediately If breathing has stopped or if a person loses consciousness apply artificial respiration and summon a physician immediately 3 3 Normal Operation 3 3 1 SQUID Electronics See the User s Manual for iMAG Multi Channel SQUID System for tuning the SQUIDs Use caution when handling the delicate fiber optic cables connecting the Flux locked loops and SQUID control electronics Do not bend smaller than a 10 cm radius 3 8 2 Handheld Controller The Hand Held Controller HHC shown below controls all of the motion of the bed da
72. e 2 1 and one at a better site Figure 2 2 In terms of magnetic fields one large division is equivalent to 2 2 mGauss or 250 nanotesla You should also ignore the thickness of the field plot as that is due to the high bias frequency of the flux gate magnetometer used to make the measurements What is important is the average movement of the line As can be seen in Figure 2 1 there are two structures to consider The first is a lower frequency drift that occurs over tens of seconds with variations on the order of 250 500 nanotesla The second is the much more rapid 750 nanotesla spikes that occur multiple times over the 500 second measurement cycle Figure 2 2 shows the measured field noise in a better location As can be seen removing the flux gate high frequency signals there is significantly less low frequency drift 250 nanotesla and no observable spiking Clearly the second site is superior to the first Figure 2 1 Poor Site Figure 2 2 Good Site In general what you want to avoid when siting any SQUID magnetometer are elevators subways and trains automobiles and any other large metal especially containing iron or steel objects Anything that gives a low frequency signal may cause the model 5700 biosusceptometer to give inaccurate results Powerline mains fields at 50 Hz should be below 1 microTesla 0 01 gauss To avoid ground loops and subsequent 50 Hz pickup the system requires an electrical Model 5700 B
73. e of Susceptibilities Although contaminants in the lung can be ferromagnetic e g inhaled dust from welding no known human tissues are ferromagnetic Iron storage molecules such as ferritin and hemosiderin are paramagnetic with x 10 This paramagnetic response is directly proportional to the number of iron atoms present in these iron storage molecules Thus a magnetic susceptibility measurement can directly determine the iron concentration In reality if there are diamagnetic or other paramagnetic materials present in the sample being measured they must be accounted for Fortunately other than iron storage molecules the human body does not contain other naturally occurring paramagnetic substances in measurable quantity While not paramagnetic body tissue is diamagnetic with X 9 109 guite close to that of water By taking into account the diamagnetic background contribution of body tissue and ignoring the insignificant contribution from molecular oxygen trace metals and deoxyhemoglobin magnetic susceptibility measurements can be used to produce direct in vivo measurements of hepatic iron concentration 4 1 2 Theory of Biomagnetic Susceptibility The response of a magnetic susceptometer is given by the size of the magnetic flux change AP produced at the pickup coil due to the presence of the object whose susceptibility is being measured The flux change is calculated from the following volume integral AP Ho Ia x r Bir B
74. e sure that there is liquid helium in the dewar If the dewar is full 210096 liquid helium may be in the neck region of the dewar causing high boiloff Wait until the liquid helium level is below 100 2 Ifthere is a high flow alarm and the level meter indicates sufficient liquid helium check to see that the top of the dewar is warm reasonably near room temperature 3 If there is evidence of icing either at the top of the dewar or on the dewar tail call the compnany Again if these instructions apply contact your Tristan representative In any case do not resume patient measurements until helium gas flow is within reasonable values If there are indications of damage to the dewar contact your Tristan representative immediately for instructions 9 3 3 General comments about dewar safety Helium expands 680 times from the liquid state at 4 2 K to the gaseous state at room temperature 300 K Theoretically this would mean that a completely enclosed cryogenic vessel filled with liquid helium and would have an internal pressure of 680 bar atm when raised to room temperature Thus it is necessary to vent the dewar not only during normal operation but when warming up the dewar No blockage of the dewar must be permitted to occur The BMD 35M dewar used has a 3 8 cm 1 neck tube that allows the helium vapor to vent to atmosphere As can be seen in Figure 2 5 a neck tube blocks atmospheric gases from entering the cryogenic vesse
75. e system to a theoretical model at the same depth was performed The depth is derived from the voltages generated by the locator loop which has previously been calibrated against the position transducer The slope of the linear fit between system response and the calculated response yields Fe the iron concentration The software is capable of subtracting a uniform drift or background measurement response i e locator loop changing the reference analysis shape and overlying tissue thickness The calibration is done on gain G20 4 1 4 Detection Coils The cryogenic sensor was constructed with a single magnetizing field and three detection coils The magnetizing field was deliberately chosen to be a first order gradient configuration for noise reduction purposes and to reduce the signal from the lung or the gut The sensor assembly comprises three detection coils two 2nd order gradiometers of different radii and a third 1st order radial gradiometer along with a 1st order persistent current superconducting magnetic field coil The field coil generates a magnetic field strength of 34 mtesla amp at the skin surface The SQUID detection coils were balanced with respect to the magnets to 1 and to external fields A radiofrequency low pass filter transformer was installed in the input to reduce the system response to rfi signals over few tens of KHz The detection coil assembly is shown below COIL SLEEVE DWG 82047 C07 A Figure 4 1 De
76. e whole procedure it is recommended that the patient be informed about the result directly in front of the data screen Especially in thalassemics this could improve Model 5700 Biosusceptometer page 32 of 76 compliance with the chelation therapy However this should be done with some care for the special psychological situation of certain patients 6 2 2 Positioning and Measurement During the whole procedure the patient especially children should be continuously informed about the different steps of the procedure An overview should be given of the three main steps positioning with sonography BLS liver volume estimation and time duration 30 40 minutes in their native language They have to be asked before for their voluntary participation In small children less than seven years old the whole procedure should be accelerated to the debit of precision in the measurement because they get bored during the time of the procedure and will not sustain their position Otherwise one would risk the biomagnetometer measurement itself Most lively children can be calmed down by getting them interested in the different steps of the procedure For very anxious children sedation may have to be envisaged 6 2 3 Patient Preparation The patient should be undressed with no metallic objects e g jewelry watches glasses earrings on his her body Items such as shoes coat pullover trousers bras and belts are not allowed Cloth underwear
77. ector The field must be decreased in lt 2 minutes to avoid excessive helium usage and potential damage to the wire leads inside the dewar sensor assembly DO NOT HEAT THE SWITCH WITHOUT MATCHING THE CURRENT unless internal field lost 3 5 2 Warming up the dewar Prior to warming up the dewar ensure that no current is trapped in the superconducting magnet 83 6 1 Failure to remove the field from the magnet will damage the magnet and void any warranty or service contract Fiberglass dewars such as the BMD 35M supplied with this system should NEVER be allowed to warm up by simply letting all the helium evaporate If this is allowed to happen and the inside fiberglass warms to near room temperature helium gas will diffuse through the dewar walls and soften the vacuum space of the dewar To prevent this you should wait for about one to four hours AFTER the helium level has reached 0 and then backfill with nitrogen gas Then let the dewar warm up to room temperature If this procedure is used it will be necessary to make sure that any water which condenses in the dewar is removed prior to using the system again This can be done by blowing dry room temperature air into the tail of the dewar WARNING DO NOT BLOW HOT AIR INTO THE DEWAR AS THIS MAY CAUSE FAILURE OF THE EPOXIED JOINTS 3 5 3 Removing dewar from Gantry The dewar can be removed from the gantry by reverse of the above procedure Make sure that the dewar lifting straps are secu
78. ed 3 2 2 System Calibration The system calibration is covered in 4 1 3 The position transducer and locator loop calibration are very essential to the system operation and accuracy of the Fe The actual number that the system yields is calibrated against a plastic phantom The system is calibrated on G20 3 2 3 Ongoing Maintenance 3 2 8 1 Liquid helium level and flow monitoring The system use of helium must be carefully monitored The flow meter is read by the system software and has alarms at 200 and 2000 std cc of helium gas minute SCCM Per initial system designs the level meter is not read by the software but is manually entered This allows for noise free data acquisition The helium level is read by connecting the cable at the top of the dewar reading the level meter and then shutting the meter off and disconnecting the cable The value read may be entered into the software at any time to estimate helium transfer time The front panel software screen is only the estimated rate per last data entry Note that aftet first cooling a portion reflects the increased boiloff due to the initial transfer As the interior portions of the dewar sensor array achieve stable temperatures the boiloff decreases to an equilibrium value 3 2 3 2 Low and high flow conditions The system has flow alarms set at 200 low and 2000 high SCCM of helium flow The front panel display is not measured It is an indicator only 3 2 3 3 Liquid helium refill
79. el From the Final panel the user can CONTINUE save just acquired data to the Patient File and advance to the Locator Loop Positioning panel REDO discard just acquired data to the Patient File and advance to the Locator Loop Positioning panel ABORT discard acquired data and advance to the Main Panel PRINT save the just acquired data to the Patient File print the On line Report and advance to the Main Panel The Main Panel contains the Menu Bars described in the sections below allowing the user to access routines for various hardware tests liquid helium transfer Data Manipulation including Locator Loop and Background Susceptibility calibration SQUID signal acquiring vs time designed to acquire signals over extended periods of time up to 24 hours and System Help Wake up HW Initialize Load Files Contig MERO Function SW Diagram Speed U Full Halt Patient Info by LW Char p Start data Maindata sQUIDvs LLvsPos On line Final data screen acq b Pos Plo LL Postipning d Plot calc Data File e Stop bed etc detect water bag off or bed off Time
80. er reference is recommended in routine measurements Model 5700 Biosusceptometer page 38 of 76 Measurement Results a r m LE Cay mper 2 on 7 Pina An Tun at ran a7 1508 In 728i 137 150 BS na E ROLD A ug proposta SOTH ug fp negam SOMO C wg Feli vegan Mean of Marked Runs for 556 1148 1598 7197 2830 uy Fulig argue Total Mean amd Error saat 3270 2 4 gw SAM beg ten i2 3m Lamm 4 Care ct kel vern Figure 6 11 Measurement Results Several Panel At the bottom of the measurements results panel is a calculation of the mean of the measurement runs Only those runs N1 N2 etc that are checked will be calculated For precision measurements sufficient time should be taken to position a patient ideally with no compromise to x y displacement and 5 measurements vs water reference as well as 2 vs air should be performed There are different ways to regulate the patient s breathing rhythm This can be done with clear short commands or just observing the rhythm on the screen and stopping further breathing on command In some patients the best liver position may be also in the inhalation phase In some small children the measurements have to be done without any breathing regulations Breathing is of critical impact on the quality of the measurement and the iron quantitation If there is any doubt about the influence of the lungs on the measurement a control run with maximum lung contribution inhaled has to be p
81. erformed Measurements in small children In small children the whole procedure of positioning ultrasound and measurement has to be speeded up The computer dialogue patient information has to be carried out in advance with estimated sonographic data Only two ultrasound images sagittal transversal should be taken Air runs may be performed at first in order to get the children used to the whole procedure and maybe to analyze these data vs air reference later on The water bag load should be increased slowly from run to run from 4 6 kg to 7 8 kg No attempt may be undertaken to hold the breath continuous fast breathing will also do some smoothing on the response curves An analysis with real patient information data has to be performed after the measurement Model 5700 Biosusceptometer page 39 of 76 6 2 9 Determination of the effective thorax geometry by biomagnetometer measuremenis The difference of magnetic volume susceptibilities of water and air is well known AX water air 9 396 10 SI The difference of SQUID voltages of an object measured vs a water and air reference depends then only from its unknown geometry at the borderline between water coupling membrane and thorax surface Thus performing additional runs at least one vs air would result in the calculation of an effective radius for the assumed simple spherical geometry of the anterior thorax shape This calculation is straight forward the SQUID voltages from
82. est Panel Run Locator Loop allows to test the locator loop functionality Model 5700 Biosusceptometer page 54 of 76 ENS Figure 8 14 Locator Loop Test Panel Time Measurement panel acquires data from SQUID channels and stores the data in the file The routine has been designed to monitor SQUID outputs with low data acquisition rate over extended periods of time to monitor the magnetic environment The user is allowed to choose the SQUID gain data acquisition speed and time In addition this routine provides real time data display The user can also set the display update rate which is different than the data acquisition speed and the display multiplier This changes the X and Y axis on the display this does not change the actual data recorded in the file Del WEL silii Figure 8 15 SQUID Low Frequency Test Panel Liquid Helium Monitor routine should be always used during liquid helium transfer This routine reads the liquid helium level and calculates helium transfer rate It also prompts the user to input the helium level value manually and specify transferring condition The software gives estimated liquid helium level based on the dewar boil off Model 5700 Biosusceptometer page 55 of 76 Bel EOS ss gm Figure 8 16 Helium Transfer Panel el HEY o ge Figure 8 17 Helium Set Panel Help provides information on the operating system etc 8 5 Utilities for Locator Loop and Background Susceptibility Calibratio
83. for return S LD EM ss spas e dp euo On eh ee A Spa 16 2 6 2 Return from Customers outside the U S sitio 16 e O ede eee 16 3 1 Introduction ED SE RR e as 16 et A Al PCPA ee deed 16 321 AMIE IC OO a a E 16 11 2 System Calibration setas eo eo cie env dada ride lal sal dad ab 20 1k 3 Ongoing MAENE it ad deve ees 20 1 1 4 SafetyPrecautionsforhandlingeryogenicliguids 21 1 5 Normal Operation a a ae ll dn 22 1 3 1 SQUID BEE TEE 22 1 3 2 Handheld Controller naciona nu a an ila ardid 22 1 3 3 Magnet Pwer S pply reanna al nnen ata anal Us ata E ii 23 ii D war and BEE 23 Model 5700 Biosusceptometer page iv of 76 4 6 13 9 Patent E s ouis Re EE cet ais eld 23 E E BAS en mai erectione ke E M MEE DM E 24 LS ee ee A rS 24 1 4 Lig uid Helim evel Meter sezenler S on ran 24 1 5 Taking the System Out of EY LD EN 25 1 5 1 Removing field from them gt Sui e di ale Sa 25 1 5 2 Warming up the deWar eite do dias 25 1 5 3 Removing dewar from Gantry cuve doe een ey GUS dada da DSG US ATE An 25 Theoty of Operations emeli A bibe sal eenen 23 41 Principles of biosusceptometry s ai e cade va cass pas b A a 26 dll Magneto Susceptibility us am e e ii 26 1 1 2 TheoryofBiomagneticSusceptbility 26 E D EDO uet e e PPK RE eee e P o 28 gt Detection EE Ree eet ele RS bodas 28 14 55 SQUID CHUY piorra el VH TN maal ids beatae eae 28 1 1 6 Magne
84. gain if not continuing with sonographic organ volume estimation It is good practice to inform the patient about the outcome of the online analysis directly in front of the biomagnetometer although some caution may be used for psychologically sensitive patients 6 3 2 Volume estimation by sonography Ultrasound Liver and spleen volumes can be measured by a sonographic scan technique under laser alignment control of the ultrasound linear probe It is recommended to do this after obtaining the most important information on organ iron concentration The liver is scanned by sagittal sections the spleen by transversal sections at a gap distance of 2 cm For large organs two images have to be combined with special attention of the overlay zone It is recommended to start the scanning near the medio clavicolar line Special care should be devoted to a vertical position of the probe Every image be frozen and written into the imager s sine loop The total procedure is documented in the volume estimation protocol and has to be recorded on video tape with documentation of video tape no start address and end address for later analysis work Model 5700 Biosusceptometer page 40 of 76 6 3 3 On line analysis The online analysis is performed in the 1 approximation model of biosusceptometry The magnetic susceptibility of the overlying thorax tissue is calculated from the body mass index and a preliminary thorax geometry is assumed from the torso cu
85. h frequency eet tte nante eh Ret sae enata na eio 52 Pigure 5 5 Locator Loop KEE 53 Figure 5 9 Position Transducer NK 53 Figure 8 10 Water Pressure vs tite ont ayi sapla yalanda age ee abes a a e e 53 ett Se e Test Pane EE 54 Figure 8 12 Bed yele Test Panel iude de EN 54 Pigure s 13 SOU UD Range Test Panel esed ali hace ceeds a kadan ortis pe Da ada 54 Figure 8 14 Locator Loop Test Panel EE 55 Figure 8 15 SQUID Low Frequency Test Panel enne 55 Ligure S 16 Helium Transfer Panel e qe ea aes 56 Figure 8 17 Hellum Set Pal eher 56 Figure 8 18 Locator Loop Calibration 2e ioci eret basen d eot ces EE 54 Figure 8 19 Locator Loop Calculation Panel seti Ges ce a ee 58 Figure 8 20 Susceptibility Background Input Panel 59 Figure 8 21 Susceptibility Calculation Result Panel eee 59 Figure 9 1 System EE 60 Figure 11 1 Water Bag Setup Screen WBC STARTER 69 Figure 11 2 Program Load Screen WBC response to IN 2 021 eee 70 Figure 11 3 Status Command And VAR armere utd 12 Model 5700 Biosusceptometer page vii of 76 Figure 11 4 iFL 301 Pigtail Connector Pinout Face View 73 Figure LI 5 Dewar Cable A iiec RM ERMEYE d eh MR Mti eiut 74 Fig re 11 6 Dewar EE 75 Figure LI 7 Dewar Cable EE 76 Tables Table 3 1 SQUID T ne P rainet rs 7t ip etit es e erii ia 18 Table 4 1 table ok te EE 26 Table 10 1 iFL 301 Pigtail Connector Pinout Face View 73 Model 5700 Bi
86. i function Parent N I PCI 232 4 Isolated Communications Port COM6 N I PCI 232 4 Isolated Multi function Parent N I PCI 232 4 Isolated Multi function Parent N I PCI 232 4 Isolated Communications Port COM5 Primary IDE controller dual fifo Intel r 82801AA Ultra ATA Controller Secondary IDE controller dual fifo page 67 of 76 ckckck ck ck ck ck ck ck kk kk kk AAA UPPER MEMORY USAGE SUMMARY kck ck ck ck ck ck ck ck ck kk kk kk kk Memory Usage Summary 00000000h 0009FFFFh System board extension for ACPI BIOS h 000A0000h 000AFFFFh Intel R 810e Chipset Graphics Driver FSB133 000B0000h 000BFFFFh Intel R 810e Chipset Graphics Driver FSB133 000F0000h 000FFFFFh System board extension for ACPI BIOS 00100000h 00FFFFFFh System board extension for ACPI BIOS 01000000h 07EADFFFh System board extension for ACPI BIOS F4000000h F7FFFFFFh Intel R 810e Chipset Graphics Driver FSB133 FC000000h FEFFFFFFh Intel r 82801AA PCI Bridge FC000000h FCFFFFFFh XPERT 98 PCI English FD000000h FDOlFFFFh XPERT 98 PCI English FD020000h FD020FFFh XPERT 98 PCI English FDFFB800h FDFFB87Fh 3Com 3C920 Integrated Fast Ethernet Controller 3C905 FDFFBCOOh FDFFBC7Fh N I PCI 232 4 Isolated Multi function Parent FDFFCOO0h FDFFCFFFh PCI 6031E FDFFDOOOh FDFFDFFFh PCI 6031E FDFFEOO00h FDFFEFFFh PCI 6025E FDFFF000h FDFFFFFFh PCI 6025E FF000000h FF0O7FFFFh Intel R 810e
87. ially under the waist in the case of spleen measurements Figure 6 3 Subject Location Only a careful positioning guarantees a good quality of measurement Positioning is adjusted under sonographic control and laser cross alignment with respect to maximum organ volume on top minimum skin organ distance absence of any visible lung influence in the window of the 10 cm linear ultrasound probe and minimization of air influence within the intestine After readjustment the appropriate position is frozen under laser cross alignment by evacuation of the patient cushion For precise measurements a bedside procedure is mandatory i e positioning under ultrasound imager control and biosusceptometry have to take place on the instrument s patient bed in the same room Moreover only an ideal patient position see 5 2 7 guarantees a correct distance measurement by the locator loop without any displacement under the water bag and a geometry approximation that fits to the analysis model 6 2 6 Assessment of geometry parameters by sonography Under laser alignment control four ultrasound images are performed at the measurement position From the sagittal and transversal images the shape of the organ is determined by the three half axes of an ellipsoid especially fitted to the upper contour of the organ liver spleen In case of the spleen the main axis would be in the longitudinal direction instead of sagittal Two further images in the diagon
88. iform medium of bodily fluid since approximately 7096 of the human body is water this is very close to the susceptibility of the body s liquid composition Filling draining and continuous fill during a measurement is computer controlled via the software 1 5 Position Locator The position of the patient s liver with respect to the SQUID detection system is critical to achieving ideal results This system is comprised of a set of signal coils a signal generator and a lock in amplifier The signal coil is placed on the skin of the patient over the center of the liver determined by ultra sound There are three coils over laid two planar gradiometers double D one rotated 90 to the other and a larger coil around the outside of the double Ds which serves as a gross locator coil see Figure 1 3 Magnetometer coil a laan S Double D Coils 4 E amp um E on o o PES EN 8 q gt Coil shown displaced Detector system passes over one diameter for clarity one coil to the other coil Figure 1 3 Gradiometer Double D Coils Figure 1 4 SQUID vs Position for Loop The signal generator is used to generate different frequencies for the each double D coils The double D coils have a response shown in Figure 1 4 that when moved under the SQUID detection system produces a null zero when the double D signal coil is directly under the detection system With the second coil turned 90 from the f
89. inate surface e Multiple access panels to provide easy access for maintenance e Internal routing of cabling and water piping e Multi section construction to allow easy transport of subsections If additional vibration dampening is needed some of these sections can be filled with sand 1 8 Computer Control and Data Collection System 1 8 1 Component Item Overview The Computer Controller and Data Collection System allows the user to modify the system configuration from the computer and collect data This includes a desk and electronics rack for the SQUID electronics and magnet power supply It controls the following functions e SQUID System gain range filters tuning and other miscellaneous settings e Helium Level meter determines the amount of liquid helium in the dewar e Magnet Control System manually charges the magnet with a dc bias field e Water Bellows Control empty and fill the water bellows The Position Locator System control of the Signal Generator and the Lock in amplifier functions as well as a visual read out of the feedback of the signals used while centering a patient e Patient Bed and Motion System manual X amp Y position adjustment computer controlled Z position adjustment electronic readout of Z position e Hand Held Controller bed height water bag fill amp empty measurement control e The computer system is comprised of a desktop computer with interface and A D or D A cards required for
90. ine parameters containing all of the system calibration parameters and the values for the hardware the input file structure is described in details in Section 6 Second it initializes the hardware to the required values sets gains and filters on the SQUID controller starts the water bag controller sets the sine wave on the HP waveform generator etc Third the user interface is started the Main Biosusceptometer Panel is loaded when the program is first started All the following software and system events are initiated from the user interface or by using the handheld controller handheld controller allows to move bed up and down water bag up and down to advance between the software panels to start and stop the data acquisition to reset SQUID Sensors Model 5700 Biosusceptometer page 43 of 76 from the Main Panel the user can initiate patient measurement The patient measurement routine is described in the 5 Sequentially panels prompt the user to fill patient information to position the patient using the locator loop start the data acquisition including start bed drop start water bag pressure regulation start data acquisition and after 10 or 16 second for the calibration runs stop data acquisition stop water bag stop bed The calibration is conducted on G20 Obtained SQUID output and Locator Loop signals are plotted vs Position Transducer signal On line calculation is performed and the results are presented on the Final pan
91. int for a calibration run The calibration was conducted on G20 The following data are saved in the Patient file 17 fields run number SQUID A voltage output SQUID B SQUID C Locator Loop voltage based on SQUID A LL based on SQUID B LL based on SQUID C Position Transducer voltage Water Presser voltage standard deviation for SQUID A voltage readings for SQUID B voltage readings for SQUID C voltage readings Fluxgate voltage reading in the X direction in the Y direction in the Z direction Cardiac signal Free channel for user defined input The data is delimited via spaces and an input into Excel can be done if the space delimiter option is used Figure 8 2 SYSDAT FF asc SYSDAT FF asc OAKLAND SITE MACHPAROO O asc SYSPARO800_O asc Sat Jul 10 21 56 36 1999 HeLevelInfoFile bin He Level is 68 000000 on Mon Jan 10 14 56 09 2000 Figure 8 3 MACHPARyy asc MACHPAROO O asc Z ZERO 3 300 3 300 3 30 closest distance cm HeBoilOff 6 0 Helium boil off in liters per day Prslp 1 653 pressure transducer coefficient kg V Iprs 0 269 pressure intercept kg Vslp 3 03 position transducer coefficient cm V otvalu 5 0 Maximum voltage for the bed motor V otv spd 4 0 bed ramp speed time sec otHighSpeedVolts Bas High speed volts for bed control otLowSpeedVolts 2 0 Low speed volts for bed control Z LL VOLT 0 4 4 locator loop source voltage V Z LL FREQ
92. into intervals with size increasing with distance from the axis and origin The liver was modeled as a hemisphere and a cylinder coaxial with the detector coils The change of flux associated with lowering the liver from a distance d to infinity was calculated for a range of starting distances representative of real measurements By fitting the output voltage V z of the SQUID detection circuitry as a function of depth z beneath the dewar tail the susceptibility X can be determined To calculate iron concentration some assumptions need to be made The easiest is to assume that the susceptibility of the liver is much less than that of the surrounding tissue e g skin fat muscle ribs etc In this situation Xliver lt lt Xtissue Additionally we assume that the thickness of the overlying tissue between the skin and liver is not excessive i e the patient is not obese and that the iron stores are homogeneous While small variations in spatial distributions will not affect the quantitative measurements significant inhomogenieties on cm scales may give rise to errors First Order Approximation to 1 order the voltage output is given by V z C AX liver P AV system Z T Vo eq 4 4 where z is the distance of the skin beneath the dewar tail C is a constant determined by the system calibration is the flux integral eq 4 3 AV system z is the contribution from the locator loops and V is the voltage at the start of the measurement I
93. ion we recommend having a minimum of 200 liters of liquid helium available for the initial cool down e Set the AMI model 135 level detector toggle switch to SAMPLE Set the interval to 60 0 minutes see AMI manual for instructions Model 5700 Biosusceptometer page 17 of 76 SQUIDS Nit PC 10L p HeXter Cooling 5 AK 100 Squid Coils T 4K shield T thermal post T Joint plate 0 1000 2000 3000 Minutes Figure 3 1 Dewar Initial cooling 3 2 1 3 Tuning of SQUID electronics A complete description on the Tristan iMAG electronics and instructions on how to tune the SQUID electronics can be found in the iMAG manual A table of the SQUID and tuning parameters is shown below Channel Volts p p Bias Mod V x100 scale 1 2 3 Table 3 1 SQUID Tune Parameters 3 2 1 4 Charging of superconducting magnet Magnetic field is injected into the superconducting magnet by driving a current through the coils Figure 3 2 To inject current into the magnet it is necessary to open drive normal or make non superconducting a small portion of the magnet coil A region of the coil actually a section of the magnet wiring well above the active portion of the magnet we call this section the persistent switch is heated up to drive the connecting section normal In that situation the circuit is
94. iosusceptometer page 8 of 76 ground spike attached at a single point Radiated rfi levels of 0 1 volts meter may impare the ability of the SQUID electronics to track signal changes Basically you should look for a location where there are no ferrous materials within a 15 perimeter of the instrument and a 30 perimeter where there are minimal metallic structures e g gurneys wheeled chairs and steel desk draws etc Moving an interference source at 15 to 30 will reduce its influence by 20 dB Obviously a ground floor is preferred to a location on a upper floor In any case the floor beneath the model 5700 must have no iron rebar in the concrete To reduce motion induced artifacts the pad on which the model 5700 sits should be vibrationally isolated from the rest of the building 2 1 2 Space Requirements Sufficient space must be allocated to the model 5700 biosusceptometer not only to allow safe and proper operation of the system but also to prevent claustrophobic reactions from the patients being measured The Site layout is shown in Figure 2 3 The water bag rack is in a different room from that of the rest of the equipment The water bag system should be operated floating from that of the main system in order to avoid ground loops z FATES E ES E va 1 ULTRASDUND
95. irst double D coil centering for both X and Y directions is possible Using two different frequency signals allows the centering process to happen in both X amp Y direction simultaneously By using a lock in amplifier to adjust the patient position for a zero output condition for both coils it is possible to center the patient directly under the detection system 1 6 Patient Bed and Measurement Motion Control The patient bed and measurement motion control is another important factor in the measurement of Iron in the Liver Once the patient is positioned centered under the detection system the patient is then lowered with water taking up the volume in the water bellows and the SQUID response recorded Key to the measurement is knowing precisely the change in relative position as the patient is moved below away from the SQUID detection system The ability to measure this change in distance is incorporated into the patient bed and the associated electronics which interfaces to the computer are provided The position measurements are integrated into the data Model 5700 Biosusceptometer page 3 of 76 file as the measurement is made on the patient Additionally during the measurement sequence the signal generated at a third frequency by the larger Magnetometer coil Figure 1 3 is used to determine the distance between the patient and the SQUID detection coils The patient bed is made of materials with low magnetic moments It can r
96. kg IMAG SERIAL PORT COM5 HP WAVEFORM SERIAL PORT COM2 WATER BAG SE defaults defaults RIAL PORT COM6 Tue Aug 22 12 24 13 2000 CPU time 10 000 SYS DATE parameters at col 25 MAG CUR POLYNOMIAL LL 6 5 Z LL COEF A 0 712313 0 000000 Z LL COEF 0 041789 0 000000 Z LL COEF 0 479962 0 000000 LL CURRENT calibration SO A RANGI SO B RANGI EJ Pi PI GO C RANGE MIN DIST LL E EE EA ut E 2 604440 Distance by LL 3 082823 1 886074 0 Distance by LL SQUID B 3 314145 2 955371 0 368186 0 419535 1 279638 Distance by LL SQUID C 7 068 20 50 50 1 8000 Model 5700 Biosusceptometer E 6 po 3 778031 1 3 SQUI SQUI gt SQUI Magnet current A lynomial or Sendai Function 71500 2 256156 2 418397 SQUID A 083270 0 755184 0 091974 mA LL current during D A gain D B gain D C gain minimum distance for LL cm page 47 of 76 MAX DIST LL 16 000 POLYNOMIAL LL WTRB 5 LL_WTRBAG_WATER_A 81 43093 LL_WTRBAG_WATER_B REEE SQ B maximum distance for LL 5 th order polynome 1 z 0 000000 1 63297 13 43863 55 01294 107 78158 LL water bag backgrnd vs water 0 000000 0 23858 0 98948 1 56687 0 000000 0 000000 water bag backgrnd vs water SQ A 1 z LL WTRBAG WATER C 0 000000 0 33478 1 28797 0 93717 0 000000 0 000000 LL water bag backgrnd vs water SQ C SO A RANGE LL
97. l via cryopumping This is to prevent water in the atmosphere from condensing in the neck and forming an ice plug The venting helium exits from the top of the dewar insert through tubing to a flow meter which continuously monitors the gaseous flow rate and displays it as an equivalent liquid helium consumption or boiloff rate Should the rate exceed either upper or lower limits an alarm on the helium flow meter see above is triggered The upper limit would indicate excessive heat input into the system the lower indicating either exhaustion of all liquid helium or a blockage of the neck region In either case operator intervention is indicated There are two additional exhaust ports One is for the liquid helium transfer line and is normally blocked by a 3 8 plug This plug is held in by a rubber o ring that would only require 1 psi over pressure to be forced out and vent the dewar Should both the flow meter exit port and the transfer tube port be blocked a third port contains a Swagelock B 4CP2 DR 10 10 psi check valve This triple combination of active flow monitoring o ring plug and check valve reduces the potential for an unobserved over pressurization of the dewar Model 5700 Biosusceptometer page 62 of 76 9 4 Magnetic field concerns The model 5700 biosusceptometer contains a superconducting magnet While the applied field is significantly less than magnets used in MRI systems the following precautions should be taken THE 5 GAUSS
98. ment should be interrupted To prevent injury the dewar is held in the gantry by gravity there is a limit switch that will cut off the bed motion if sufficient force is placed on the dewar tail to begin to lift it The bed has skirts around it to prevent non qualified personnel from accessing the bed motion apparatus Additionally one should not place extremities near or in the skirts when the bed is being raised or lowered There is a bed trapping switch that stops the z axis motor if an object is trapped between the box and bed bottom In the case of a power failure or emergency switch actuation the bed may be manually lowered To do this open the side doors on the bed Manually move the drive belt in the direction indicated by the arrow until there is sufficient clearance to remove the patient or object When the patient or object has been removed close the doors The bed table need not be returned to its prior position the Z position transducer will automatically indicate to the control system the new position of the bed table 9 2 Water Bag The bottom of the water bag bellows is a latex product Appropriate caution should be taken with patients who have a latex allergy Do not allow sharp objects to contact the water bag They could tear the thin material and cause the water bag to spill water on either the bed or patient Depending on the stage of the measurement the water bag contains from tens of milliliters to a few liters of wate
99. n These routines help the user to fit the data which were obtained by the Biosusceptometer software for the patient measurement and extract the coefficients and errors for the corresponding fit It is the user s responsibility to know which file is used for calibration and which runs in the file are valid The calibration is conducted on G20 8 5 1 Calibrate Locator Loop The purpose of the Locator Loop Calibration is to generate a depth profile of the Locator Loop signal generated on a selected SQUID channel Follow the command buttons from top to bottom e select data file e select runs for calibration e select the SQUID channel default SQUID A the software is configured at the present time to calculate distances based on the SQUID A readings Model 5700 Biosusceptometer page 56 of 76 e select type of fit the software allows the user to use 2 formulae to establish the relation between the voltage read by the SQUID and the absolute distance in cm between Locator Loop and the pick up coil The first formula is a polynomial of log Voltage Distance A log Voltage eq 7 1 The second formula is Distance A A V A V 8 4 v eq 7 2 JA Y Additional details on locator loops and the use of equation 7 2 can be found in R Engelhardt K Vallett and R Fischer Printed Circuit Locator Loop for X Y Positioning and Z distance Measurements Recent Advances in Biomagnetism T Yoshimoto et al eds Tohoku University Pre
100. n of the dewar Liquid helium level meter read back electronics Liquid helium flow meter Magnet Power Supply and control electronics suitable for computer integration 1 8 3 The Water Bellows amp Controls Microprocessor control system located in an EMC protected enclosure Water reservoir with analog pressure and vacuum indicators also in the EMC protected enclosure Water bag assembly for mounting on the dewar Safety valve system to protect from an over pressure condition including a feedback line for motion control reversal e All lines and miscellaneous components required for operation 1 8 4 Position Locator e 3 coil Locator assembly see Figure 1 3 Signal generator and software generated lock in amplifiers 3 e Cabling and interconnects 1 8 5 Patient Bed amp Measurement Motion Control Patient Bed low magnetic signature Vacuum evacuated air mattress 25 cm of total vertical travel Manual X Y horizontal positioning Vertical location measurement system with electronics readout Computer controlled Z position controller Model 5700 Biosusceptometer page 5 of 76 1 8 6 Ganiry amp Vibration Isolation System Gantry Structure Vibration Isolation System Mounts for water bellows reservoir Helium Transfer access region Liguid helium transfer tube 1 8 7 Computer Control and Data Collection System An operator desk and two separate electronics racks are supplied The keyboard mouse 17 color monitor 10
101. naccuracies can result these conditions are not met For example an obese patient with a known normal 295 ug g iron concentration can measure significantly higher 1500 ug g if the added distance of the overlying tissue is not taken into consideration Second Order Approximation a more accurate determination of iron concentration can be made using a second order fit by taking into account the contributions of the surrounding tissue This is especially important in obese patients and situations where Xtissue gt Xliver 10 Here V z C AXtissue Diissue Z AX liver DiiverlZ Ziiver ch AV system Z Vo Os z eq 4 5 where AXtissue and Piissue is the susceptibility and flux integral of the overlying tissue respectively Zliver iS the depth of the liver beneath the skin and O is the error associated with higher order effects A multiple linear regression can be used to determine relative to the reference medium water Deviations from this model are included in a usually small linear error term Ox z 0 The liver iron concentration is then calculated as cre AXuiver S with the volume susceptibility re 1600 10 SI units for the paramagnetic hemosiderin ferritin complex See 6 1 for additional information Model 5700 Biosusceptometer page 27 of 76 4 1 3 Calibration To determine the actual equivalent iron concentration a linear fit between the actual Biosusceptometer system response at a depth and the calculated response of th
102. ng shipment This strap should be released so that the bed is free to rise CAUTION Once the strap has been released DO NOT try to lift upper bed surface The height of this surface must ONLY be varied using the electrical motor via the Hand Held Control unit and software Once the turnbuckle has been removed and all the system electrical connections have been made the bed should be tested for function Verify that the tape switch the counterclockwise CCW limits and the clockwise CW limits all function Verify that the position transducer is read by the software l Er vE men D s eum n d 47 107 Ca Ue FLOOR JEW SHOWS BELLOWS AT MAX EXTENSION JEW SHOWS BELLOWS AT KETSACTED HEIGHT Figure 2 9 Bed assembly Model 5700 Biosusceptometer page 15 of 76 2 5 4 Interconnects 2 6 Reshipment 2 6 1 Repackaging for return shipment If it is necessary to return the system you should repack the unit in its original container if available For this reason it is advisable to save the original crate s or manufacturer s packaging sent by Tristan however if this is not possible use the following instructions for recapping 1 Wrap the unit in either bubble wrap or foam rubber 2 Cover the bottom of a sturdy container with at least 8 cm of Styrofoam pellets or shredded paper 3 Set the unit down onto the packing
103. ntroller HCG nein a ties tue 23 Figure 3 6 Liquid helium level meter block diagram eene 24 Figure 3 7 Helium level meter connector noe K ie 25 Figure 4 1 Detection Coil Assembly raio pesa ee Be ite ke ee alise dites tuta dius 28 Figure 4 2 SQUID input Schematic re beasties aad des 29 Figure 4 3 Magnet Schemano stane en en a e a a aaa 29 Figure 4 4 Magnetic Hield Profiles td A heen 30 Figure 6 1 Software Introduction Screens ii A a d dh 32 Figure 6 2 Subject Data Input Screen estie Eenelter 33 Figure 6 3 Subject Location eie lssi GANSER ke Re Sae asid 34 Figure 6 4 Input Screen and Locator Loops usada tit o Pete beate teal ee d Prose ens 35 Figure 6 5 Main Console and Strip Chart Screen FP Monitor eee 36 Figure 6 6 Strip Chart Panel iui e sopas talo pes AER 36 Figure 6 7 Measurement MEIGOU nen cc nakdi sakil Eege baang 37 Figure 6 8 SQUID ise Za Dalal e recta Mae Pa aa ge 37 Figure 6 9 Locator Loop Volts vs Z SERA 38 Figure 6 10 Measurement Results Panel si ied iocus daer lupe 38 Figure 6 11 MeasurementResultsSeveralPanel 39 arr De euer a aa diens 42 Ligure e pyar SSC TAC oat a sa ll le l pde 44 Figure 8 2 SYSDAT TEE 45 Eig re 8 3 MACEHPARSV SQ eo Deoa eh ege amil deus a a ayal q 45 aere SA S YS O 47 Figure 8 5 Sample Data Ple qe e ida ada 48 Pigure 56 Code Compile List a ya 52 Figure 8 7 SQUID Test Panel hig
104. of the magnetic volume susceptibility of the respective tissue as long as the usually paramagnetic iron contribution ferritin and hemosiderin iron overwhelms the usually diamagnetic biological tissue contribution water skin muscle connective tissue fat The iron concentration cre is related to the relative magnetic volume susceptibility Ax by cre AX X n with the specific susceptibility Xa 1600 10 SI ug giissue for the paramagnetic hemosiderin or ferritin iron complex In contrast the magnetic volume susceptibilities of most biological tissue is similar to that of water i e Xwater 9 032 10 SI The measurement is performed versus a water reference medium water bag covering the upper body with the advantage of reducing perturbation effects from the body surface and its tissue Thus to 1 approximation one has to consider a magnetized organ moving in a non homogeneous magnetic field within a water surrounding To date the method can be applied only to organs such as livers and enlarged spleens 2300 ml with a total error of Gre 50 400 ug grissue This replaces the biopsy with quantitative physicochemical estimation of the iron content Model 5700 Biosusceptometer page 30 of 76 5 1 1 Typical Applications The most relevant applications of this method are related to iron overload diseases such as genetic hemochromatosis and siderosis caused by blood transfusions The following main applications have been establishe
105. of the human body is non zero it is necessary to provide a magnetically uniform background as the patient is lowered beneath the detection system A water bellows assembly Figure 1 2 is attached to the bottom of the dewar This water bellows simulates the background of the body since the magnetic susceptibility of water is within a few percent of the body s susceptibility Xtissue 9 10 The water bellows or water bag system consists of the bellows water bag low magnetic signature mounting hardware for the dewar fill drain lines water reservoir and hydrostatic control hardware and electronics for draining and filling the water bellows The water bag electronics include a computer interface and are integrated into the system control software The water bag system is fit with pressure valves to insure that the bag could not be over filled pressurized In addition a heater assembly is integrated into the reservoir and bag to keep the water at body temperature 37 C Model 5700 Biosusceptometer page 2 of 76 To perform the measurement the patient is positioned centered under the SQUID detection system and the water bellows filled The patient is then lowered down from under the SQUID system while the SQUID system output is recorded During this movement the water bellows is continuously filled to provide a uniform magnetic background This makes it appear as if the subject liver is moving away from the detection system in a un
106. ogoriwie WinLink Cmd Mode Send Fax Explorer DOS Pimpt _VT400 Xmodem direct connect Com 138400 N83 rd Q sd cd cts 1 42PM BI Procon Pius Terminal Figure 11 2 Program Load Screen WBC response to IN 2 021 Name Description help lt VAR gt shows variables PR prints lt EXPR gt STAT sends status to RS232 VER sends versiono to RS232 FI till opens DV2 NE neutral close last DVn EM empty open DV1 RE regulate ST stop needs params LL list logs since DATE LW list warnings RD read ax value and show it WR write ax value TE test WRL write regulate log EP empty pulse FP fill pulse CS change screen OKAY Variable List Nam Description Valu Flags DEBUG 0 00 rw DEBUGIN 0 00 rw BEEP 1 00 rw LCD 1 00 rw Model 5700 Biosusceptometer page 70 of 76 UJ E gt A A H H is Gl LCDCONTRAST dc p EZ D Ke E E H HO HS x Ei JJ Ti D Z Jg n T D A bi KI ATA AI S AI C AI P AT P ATP ATP AIM AT AT ES AI P AI A AI S AI C AT P AI E AI P AT P AT ATM AI P AI P AI A AI A AT A AI A AI S AI S AI S AI S Model 5700 Biosusceptometer AI OFFSI AI RANGI KG OFFSI KG FACTOR Di p pH H H CTTEMP_SF ETTEMP SE RATETEMP SF RESSBAG SF RESSAIR SF 5V SF 15V SF 15V SF
107. ole and Strip Chart Screen FP Monitor The patient is asked to breathe in his her normal manner and to stop breathing in the exhaled phase for 10 seconds Figure 6 6 Strip Chart Panel Then the measurement is started under processor control The bed then moves down dynamically by 8 cm with the water bag inflating automatically at a slightly increasing pressure The data acquisition process takes place with 100 data points in each of the 8 channels At the end position the water bag deflates automatically The figure below Figure 6 7 shows the FP display during the acqusition The actual data is not shown to avoid timing problems Model 5700 Biosusceptometer page 36 of 76 Figure 6 7 Measurement timeout The figure below Figure 6 8 shows the output of the instrument after the acgusition is done The 3 channels show can be viewed to evaluate if the data was clean After this screen the output of the locator loop is shown Figure 6 9 I LOCATOR LOOP Organ LIVER First Pressure kg 0 82 0 06 Model 5700 Biosusceptometer page 37 of 76 Figure 6 9 Locator Loop Volts vs Z Data The two 3 trace screens showing the SQUID voltages and the locator loop voltages vs the bed position transducer have to
108. oll in both X amp Y directions allowing for the patient to be centered under the detection system Once in position a floor brake system is latched so the bed will not move horizontally under the detection system The patient lies on the bed table top which also allows X amp Y movement when positioning the patient beneath the sensor array prior to measurement A brake allows the table top to be locked in position Vertical motion is integrated into the bed and has a total vertical travel of nominally 25 cm while the measurement is made with a patient vertical motion of 15 cm The extra 10 cm is provided to account for the variable size of patients that might be studied Nominal bed speed during the measurement sequence is 0 7 1 cm sec 1 7 Gantry and Vibration Isolation System The dewar amp probe assembly along with some of the plumbing for the water bag is held in the gantry The structure is design to minimize vibrations from the floor The gantry is constructed of materials having a low magnetic moment and is design to offer easy access to the patient and the water bellows system The gantry is design to provide easy access to the dewar for re filling the system with liquid helium The vibration isolation sub system of the gantry consist of vibration mounts to decouple the natural vibrational modes of the structure the gantry floor and building Features of the gantry include e Esthetic design with all wood construction with durable lam
109. ontaminants could result in incorrect measurements or dewar sensor damage Model 5700 Biosusceptometer page 16 of 76 3 2 1 1 Liquid nitrogen precool Be sure that the dewar is dry before proceeding Water should never be allowed to collect inside the dewar Water has a large enthalpy and will require significantly more liquid nitrogen and or helium to precool a warm dewar that has water in the inner vessel The system should be precooled with liquid nitrogen to ease cooling and conserve liquid helium Ideally liquid nitrogen should be transferred into a tilted dewar Do not shock cool the dewar interior The dewar s being tilted by about 3 at the edge of the base will allow the liquid to cool the belly of the dewar first and then cool the feedthrough This minimizes the stress being placed on any vacuum connectors The initial fill with nitrogen should take about 5 liters The amount is chosen by watching the temperature until liquid collects and then letting the dewar warm above the liquid temperature Do not overfill otherwise you will have to wait until the liquid nitrogen has evaporated before proceeding to the next step When the dewar has no liquid nitrogen it is then safe to transfer the liquid helium This normally takes about 6 hours to cool 3 2 1 2 Initial transfer of liquid helium e Verify that the liquid helium level detector is operational Instructions on the use of the AMI model 135 can be found in its manual separately supplied e
110. osusceptometer page viii of 76 1 Introduction 1 1 Purpose of the Manual This manual is designed to provide operating instructions necessary for the user to operate the Tristan Technologies model 5700 biosusceptometer The procedures in the manual make no attempt to instruct the user in methods or techniques of iron overload or anemia measurement The necessary methods and techniques may vary according to the user s needs and are to be determined by the user The operating procedures are given to provide the user with the information necessary to operate the model 5700 in a safe and efficient manner If there are any concerns about instructions contained within this manual the user is encouraged to contact Tristan Technologies 1 2 Overview of Components and the System The Tristan model 5700 biosusceptometer is designed for measuring magnetic fields from paramagnetic materials in the body such as hepatic iron stores in the liver Details on the measurement technique can be found in Biomagnetic susceptometer with SQUID instrumentation D N Paulson R L Fagaly R M Toussaint and R Fischer IEEE Transactions on Magnetics MAG 27 pp 3249 3253 1991 The system pieces are shown in the photo below The major physical subsystems are the gantry bed dewar sensor assembly attached to the gantry data acquisition equipment rack water bag system equipment rack and data analysis station not shown Figure 1 1 System dewar gantry
111. ply 100 C 0 500 multiplier for channel C gain 100 Multiply 50 A 0 400 multiplier for channel A gain 50 Multiply 50 B 1 000 multiplier for channel B gain 50 Multiply 50 C 1 000 multiplier for channel C gain 50 Multiply 20 A 1 000 multiplier for channel A gain 20 Multiply 20 B 2 500 multiplier for channel B gain 20 Multiply 20 C 2 500 multiplier for channel C gain 20 ultiply 10 A 2 000 multiplier for channel A gain 10 Multiply 10 B 5 000 multiplier for channel B gain 10 Multiply 10 C 5 000 multiplier for channel C gain 10 Multiply 5 A 4 0000 multiplier for channel A gain 5 Multiply 5 B 10 000 multiplier for channel B gain 5 Multiply 5 C 10 000 multiplier for channel C gain 5 Multiply 2 A 10 000 multiplier for channel A gain 2 Multiply 2 B 25 000 multiplier for channel B gain 2 Multiply 2 C 25 000 multiplier for channel C gain 2 Multiply 1 A 20 000 multiplier for channel A gain 1 Multiply 1 B 50 000 multiplier for channel B gain 1 Multiply 1 C 50 000 multiplier for channel C gain 1 Nrun 10 default number of runs Ndatpts 100 default number of data points per run Nchan 16 default number of data channels LinRegressionMode 2 0 std dev weighting 1 statistical weighting 2 no weighting WBC_version 2 WBC program version frmpl 10 0 Torino WBC profile parameter srmpl 28 0 Torino WBC profile parameter svall 3 4 Torino WBC profile parameter srmp2 1 6 Torino WBC profile parameter BSF LC Freq 550 SQ
112. port a caths but active perfusion pumps have to be deactivated e patients with a latex allergy may run a risk from skin irritation by the latex foil of the water coupling membrane e children between three and five years old can often be measured in most cases without sedation after some time of accustoming to the procedure This will be facilitated by the novel smaller water bag Moreover less precise measurements Gr 4 600 ug g versus air reference can be tried in children less than three years old e measurements in adult obese patients with body mass index gt 29 kg m are less precise Ore 3 500 ug g due to the large influence from fat in the overlying thorax tissue Due to a better spatial resolution in the model 5700 SQUID biosusceptometer the influence of the overlying thorax tissue will be better discriminated versus the liver and this error will become smaller 5 1 3 Clinical data needed for evaluation of body iron stores Data such as Hb serum ferritin transferrin saturation SI TIBC NTBI and serum vitamin concentrations C E may be determined from a blood sample taken at the day of performing BLS after overnight fasting and discontinuing of any chelation therapy for 12 hours Other data depend on the documentation protocol of the patient s health care center with the following priority Model 5700 Biosusceptometer page 31 of 76 e representative iron transfusion rate or accumulated iron until date of BLS or las
113. ps the sensor cold and the magnetic field in the magnet 3 3 5 Patient Bed The Patient bed lifts and lowers the subject and reports the bed Z position and also has emergency shut offs for clockwise and counter clockwise limits and if a person puts a hand between the lowering surfaces Model 5700 Biosusceptometer page 23 of 76 3 3 6 Water Bag The water bag fills and empties either through the LabWindows CVI control software or via a terminal program 19 200 8 1 N none The bottom membrane is latex 3 3 7 Computers The computers and data acquisition are described in 1 8 7 and shown in the system schematic One computer is for acquisition and the second is for analysis The computer interfaces with 2 National Instruments I O cards and 3 serial ports A printer and a flat panel monitor are also provided 3 4 Liquid Helium Level Meter The system includes a 14 superconductive filament liquid helium level sensor schematic diagram is shown in Figure 3 5 The sensor uses a single filament of NbTi as the level sensing element To activate the sensors a small constant current approximately I 2 70 mA is applied to the filament forcing the portion of the filament which is in the helium gas to become resistive The portion of the filament in the liquid remains superconductive By reading the voltage across the filament one can determine the length of filament which is resistive Leads Heater 460hm V e
114. r Over pressurization of the water bag can cause discomfort in patients The water bag pressure should not exceed and equivalent force of 20 30 lbs in adults and 8 lbs on children The water bag temperature should be kept at 37 C In the event that water bag bursts stop the measurement and remove the patient allowing him her to dry off Replace the water bag bellows 3 2 3 5 and restart the measurement process De ionized water should be used in the water bag system 9 3 Dewar Safety See 3 2 4 for safety in handling cryogenic liquids If the liquid helium flow alarm activates stop all measurements and remove the patient 9 3 1 If the flow indicator indicates low flow lt 200 SCCM 1 check the liquid helium level meter to make sure that there is liquid helium in the dewar If the dewar is empty refill the dewar Model 5700 Biosusceptometer page 61 of 76 2 Ifthereisalow flow alarm and the level meter indicates sufficient liguid helium check to see that the hose between the dewar and the flow meter has not come loose or developed a leak 3 Ifneither 1 or 2 apply contact your Tristan representative for instructions The model BMD 35M dewar is held together by vacuum Should the dewar lose vacuum contact your Tristan representative for instructions before attempting to evacuate the dewar or refill the dewar 9 3 2 If the flow indicator indicates high flow gt 2000 SCCM 1 check the liquid helium level meter to mak
115. r the readings may not be accurate 10 3 Bed Maintenance The bed must be lubricated every three months and the belts checked for tension Care Watch for the pulley screw on the motor if power is applied and the motor turns This is not recommended Do not apply power if the sides are uncovered 10 4 Water Bag Maintenance The water bag must be checked for leaks periodically and the system kept free of trapped air Maintenance of the water bag is covered in a separate document 10 5 Mechanical Pump Maintenance Check the pump for backstreaming and oil periodically 10 6 Transfer Tube Maintenance The two piece flexible transfer tube has an evacuated region in each section between the inner tube and the outer tube which is at room temperature If the vacuum deteriorates then the thermal isolation between the two tubes will also deteriorate and the outer tube will frost up along its whole length when a transfer is attempted It is possible that it will be impossible to transfer any liquid helium The cause of such a deterioration may be either a leak or the mistaken opening of the evacuation valve If the problem is a leak it must be fixed After repair the transfer tube vacuum space must be evacuated before the transfer tube can be used As little as 1 2 hour of pumping with a mechanical vacuum pump should be sufficient 11 Appendices 11 1 Hardware PC and National cards setup Channel list is shown below Channel assignment 7 3 90 NI
116. rely attached and that there is a safety and multiple spotters 4 Theory of Operation Model 5700 Biosusceptometer page 25 of 76 4 1 Principles of biosusceptometry 4 1 1 Magnetic Susceptibility All materials are influenced by magnetic fields How the materials respond to applied magnetic fields determines their magnetic properties Ferromagnetic materials such as iron act to strongly concentrate magnetic flux and are greatly attracted to an induced magnetic field In addition the response is highly non linear and hysteretic Paramagnetic substances metals other than iron cobalt or nickel gases like oxygen and some organic materials are weakly attracted to an induced magnetic field Diamagnetic materials H20 and some organic materials are very weakly repelled by an induced field Finally superconductors are diamagnetic but strongly repelled by an induced magnetic field The response of paramagnetic and diamagnetic materials are linear and non hysteretic Mathematically we can represent the magnetic interactions by the following equation B xH eg 4 1 where B is the magnetization of the object H is the applied magnetic field and x is the object s magnetic susceptibility Material X SI units response Ferromagnetic 1 100 s Non linear amp hysteretic Paramagnetic 10 Linear amp Non hysteretic Diamagnetic 10 Linear amp Non hysteretic Superconductor 1 47 Linear amp Non hysteretic Table 4 1 Tabl
117. rvature mapping A refinement of this model resulting in an effective thorax geometry will be established by exploiting the measurements vs the air reference After subtraction of the thorax contribution the liver or spleen iron concentration is calculated from linear regression fits independently in all three detector channels The mean iron concentration value is calculated from all selected runs in all independent detector channels These online values can be evaluated as final ones if the following conditions are fulfilled e quality of measurements is good i e no contributions from magnetic contaminants no breathing effects no trapped flux look for X A X B EC e if you feel safe with the estimation of the magnetic susceptibility of the thorax tissue look for X tis which may be the case for BMI lt 25 kg m and percentage of total body fat as expected e the deviation between the detector channels is less than 5 for iron concentrations 2700 ug g look for the ratio A B and A C in appendix 21 In all other cases a final second order analysis 6 has to be performed especially for cre lt 700 ug g BMI gt 25 kg m corresponding with Xtissue gt 0 2 far field contributions and in most spleens lung influence After the data analysis is done the data is printed via the PRINT button in Figure 6 11 The result is shown in Figure 6 12 Tristan Technologies Model 5700 BIOSUSCEPTOMETER Children s Hospital O
118. s e Verify helium level in storage dewar and dewar Open transfer port and vent port at top of probe e Begin helium transfer observing all standard cryogenic handling and safety procedures Observe transfer levels Note Dewar capacity is 35 liters e Do not continue transferring past 99 9 e Plug transfer and vent ports after allowing sufficient vent time Model 5700 Biosusceptometer page 20 of 76 Verify all connectors at top of probe are free from moisture 3 2 3 4 SQUID defluxing The SQUIDs are normalized through the iMAG software and the front panel switches Switches 1 3 Figure 3 3 control the flux in the input loop The iMAG heater controls the flux in the SQUID Both should be normalized after a magnet charge or excessive noise is suspected like a wrench near the bottom of the dewar 3 2 8 5 Water Bag Maintenance The water bag maintenance is covered in a separate document The diaphragm is very easy to rupture and care must be taken to visually observe the pressure and the degree of deflection of the bottom of the assembly 3 2 4 Safety Precautions for handling cryogenic liquids The potential hazards of handling liquid helium stem mainly from the following properties WARNING THELIQUID IS EXTREMELY COLD HELIUM IS THE COLDEST OF ALL CRYOGENIC LIQUIDS THE ULTRA LOW TEMPERATURE OF LIQUID HELIUM CAN CONDENSE AND SOLIDIFY AIR VERY SMALL AMOUNTS OF LIQUID HELIUM ARE CONVERTED INTO LARGE VOLUMES OF GAS 4 HEL
119. s of First testing the individual functions ohms volts etc e Check the voltage switch current and magnet current for correct resistance and grounds e Runcurrent in leads while monitoring the voltage e Run magnet heat switch while reading the magnet volts Then charge the magnet to full field by Check the helium level and transfer if necessary 2 running the switch normal 1 V 3 ramping the current to 10 A Model 5700 Biosusceptometer page 19 of 76 4 run the switch in Figure 4 3 to superconducting 0 V 5 thenramp the current to zero This should be done in less than 2 minutes High current boils off helium and can heat the wire leads inside the dewar assembly to destruction The discharge differs mainly in that the persistent current is first matched and then the switch is run normal and the current decreased to zero 3 2 1 5 Filling of water bag system A block diagram of the water bag fill assembly was shown in Figure 2 8 This structure must be filled with water without leaks so that the entire assembly is hydraulic and not pneumatic All air must be removed The most effective technique is to bleed from the top points and to use the pump to flush water plus air through the system so that the air collects at the high points The water bag fills and empties either through the LabWindows CVI control software or via a terminal program 19 200 8 1 N none The bottom membrane is latex It can be very easily ruptur
120. ss Sendai 1999 pp 10 98 1101 In the case of second formula the user is required to input preliminary coefficient to start the fit These coefficients should be reasonably close to the real coefficients e start calibration A e A Figure 8 18 Locator Loop Calibration the results of the fit and the actual data are output on the graph on the following panel as well as the coefficients and the standard deviation of the fit the user can reject current fit previous screen pops up where different runs can be chosen and the fitting routine can be repeated or accept the fit in this case the obtained coefficients are saved in a special file Model 5700 Biosusceptometer page 57 of 76 ml t 3v aie nm Figure 8 19 Locator Loop Calculation Panel 8 5 2 Background Susceptibility Calibration This routine establishes contributions from the Locator Loop and or Water Bag to the SQUID signal during Patient measurements The calibration is conducted on G20 Follow the command buttons from top to bottom e select data file e select the type for the background susceptibility calibration to be performed Water bag and Locator Loop vs water Locator Loop vs air Water bag vs water e select runs for the background calibration For example to perform Locator Loop susceptibility vs air calibration one should mount the Locator Loop on a plastic bottle perform the Patient run measurement then remove the Locator Loop and perform the same mea
121. surement for the plastic bottle The plastic bottle is the background for this calibration The Locator Loop signal is the difference between the first measurement and the second measurement the background e start calibration the software performs the least square fit to a polynomial Voltage A 1 Distance The output is the polynomial coefficients for SQUID A SQUID B SQUID C and standard deviations of fits the user can reject current fit reselect the runs used for background calibrations and start new fit or accept the current fit e select runs for the susceptibility calibration referring to the example above these are the runs of the Locator Loop on a plastic bottle e start the susceptibility calibration based on the polynomial coefficients for the background obtained above the contribution from the background is calculated and subtracted from the susceptibility runs polynomial fit is performed on the difference The output is the polynomial coefficients for the desired susceptibility signal vs distance for SQUID A SQUID B SQUID C and standard deviations Model 5700 Biosusceptometer page 58 of 76 The user can reject the current fit reselect the runs used for susceptibility calibrations and start new fit or accept the current fit the polynomial coefficient will be saved in a special file rae Figure 8 20 Susceptibility Background Input Panel Figure 8 21 Susceptibility Calculation Resul
122. t Fie Plots EYE KN oto perit vete ecce a 29 Principle of the clinical method BLS Leene a ala 30 LEAL Typical et EE 31 1 1 2 What type of pgatientseanbetgeasutet eguecueeiaCtdeeege e 31 1 1 3 Clinicaldataneededforevaluationofbodyironstores 31 Patient Measurements a eenn aile sem ame ik ele i 32 S LOTO Ee eten pag SE as e a DAR A A 32 6 2 Th Method of Patient Meas rement nere ss pedais edet e a ee ie tek deo eed aprende 32 6 2 1 Patient pre mfobpallonss oes A m iaa QU Sa RSE 22 6 2 2 Positioning and Measurement ui 33 623 PAE EE Te 38 6 2 4 Data needed directly prior to the measurement serene 33 6 2 5 Positioning of the patient uisi day saa badi daa dn IS dada DENS AER EE ABA 33 6 2 6 Assessmentofgeometryparametersbysonography 34 6 2 7 Positioning of the patient under the biomagnetometer eneen 35 6 2 8 Execution of biomagnetometer measurements by process control and data acquisition with LabWindows CVI program 36 1 1 9 Determination of the effective thorax geometry by measurements 40 1 3 Data Storage organ volume estimation and on line analysis 40 1 3 1 Finalization of Mean as 40 1 3 2 Volume estimation by sonography Ultrasound eene 40 153 3 O ETNEA E 41 ee 42 7 1 Simultaneous determination of iron concentration and tissue susceptibility 42 1 2 Pr cision of SQUID brosusceptometry cs iulio esee bee be
123. t Panel 8 5 3 Subtraction of Tissue and locator signal Model 5700 Biosusceptometer page 59 of 76 8 5 4 Computation and errors 9 Safety ssues The system safety relay block diagram is shown in the following section Figure 9 1 System Safety Schematic NI JUNCTION BOX ENABLE PIN VOLTAGE ReaD PIN Power Supply Alarm to Waterbag 12VDC 40mA Alarm from Waterbag 12VDC 40mA J5 Connector TO WATERBAG Relay NO TI AND GATE P N SN75451BD TRISTAN P N 03 0034 CP CLAIRE REED RELAY P N PRMA1C05B O I I l j l l y ve WATER PIN ax WARN pin at vam 1 E E O EH neo PIN 34 Let om POWER 55V Il o PIN33 b p je s END Ter te H wh Ze wer l FROM WATERBAG Le fas I Relay NC E g M L PIN 25 T I DAQ ENABLE pin 24 I GND HA l i Em DS l H 5 7 s Hu EE E H td TAPESWITCH Relay NC l l l l ui t l l Digital Relay NC DURING DAQ KXA AUX T l sv l NC Dewar Lift SW C Gantry Mount 40 oz CTIVATI NO Bed Kill SW
124. t annually transfused iron actual and year before e effective chelation rate compliance prescribed rate actual and year before e serum ALT GPT and other liver function parameters e HCV positive or negative HCV RNA activity e vitamin substitution C E e urinary iron excretion UIE e LVEF or arrhythmia s for patients with cardiomyopathy 6 Patient Measurements 6 1 Introduction This section gives a basic step by step introduction to the measurement procedure It is recommended to use this information as a starting point for developing a patient measurement protocol html Iretetest fi wes tme Fal 1 24 AALE ML Ue QUAMA LG Meel er SO Gm ont aom Figure 6 1 Software Introduction Screen 6 2 The Method of Patient Measurement 6 2 1 Patient pre information Prior to the measurement the patient should be informed about the non invasive character of this type of measurement no radiation no MRI and the underlying principle change of magnetization is proportional to the degree of liver iron concentration Additionally the patient should be informed about some surprising or curious effects the feeling of the water bag may be compared with a baby of 8 kg e the water coupling membrane could break very rare event with the effect of a small warm shower bath e if possible breath should be held usually exhaled seldom inhaled for 10 seconds with priority to the first few seconds At the end of th
125. ta acquisition and water bag functions The signals to the bed are digital enables and voltages to the motor controller The control to the water bag is via RS 232 commands The commands are self explanatory It is important to remember that not all of the buttons work in all of the software screens The control was purposely limited but can be expanded as required Model 5700 Biosusceptometer page 22 of 76 Figure 3 4 Hand Held Controller HCC 3 3 3 Magnet Power Supply The magnet power supply system of a low power current supply for the heat switch a voltmeter and a second high current supply Three similar low power heaters are used for warming the SQUID circuitry to remove trapped flux The charge circuit is shown below in Figure 4 3 The switch heater is run normal by charging the circuit to 1 volt 1V 50 ohm The SQUID input heaters are also run normal by 1 volt During a normal charge the individual functions are first tested The current and polarity of the last magnet charge must be matched unless the magnet has lost persistence the switch heater powered on 2 series switches and then the new current applied switches off and current deceased to zero This should be done in less than 2 minutes High current boils off helium and can heat the wire leads inside the dewar assembly leading to potential damage 3 3 4 Dewar and Sensor Assembly The dewar and sensor are described elsewhere The dewar kee
126. tection Coil Assembly 4 1 5 SQUID Circuitry The SQUID input circuit has two sections that must be separately normalized The circuit centers around a transformer for stripping high frequencies from the SQUID input and allowing the injection of AC signals external feedback into the detection input These lines are accessible inside the dewar Model 5700 Biosusceptometer page 28 of 76 REVISIONS APPROVED DESCRIPTION Stripper Transformer Te SQUID Channel l A 10 Pick Up Coll _ 37 jS E SQUID Heater A g ier Wed ter lt A Feedback not used Stripper Transformer M LTC SQUID Channel 2 B 24 Pick Up Coil _f 3E TES e ER 5 SQUID Heater gt Jr gene dere Feedback not used Stripper Transformer PR Te SQUID Channel 3 Planar Pick Up Col f 108 E e F t We SQUID Heater Ken Berner ekte a Feedback not used TRISTAN TECHNOLOG ES Coil Circuit Diagram Torino System TT 2056 504 ERE DESCRIPTION a APPROVED TRISTAN TECHNOLOGIES Magnet Tori ETA Figure 4 3 Magnet Schematic The magnet has 6 leads Figure 4 3 relative to its function The voltage leads measure the voltage across the superconducting magnet During regular superconducting operation there is no voltage The heater drives the magnet switch normal so that current can be trapped in
127. the nearest Tristan representative or the Tristan factory and describe the problem in detail Please be prepared to discuss all surrounding circumstances including installation and connection detail After obtaining authorization from the Tristan representative return the unit for repair along with a tag to it identifying yourself as the owner Please enclose a letter describing the problem in as much detail as possible 2 4 Unpacking The model 5700 and accessories is shipped in several crates Before opening any of the crates inspect the crates for obvious shipping damage If damage is observed immediately notify the freight carrier and Tristan prior to opening the crate s Open all shipping containers and carefully remove all supports cushioning and tape where applicable being careful to secure any movable or loose parts Carefully inspect all components for signs of damage dents scratches punctures broken controls or indicators etc If damage is observed immediately notify the freight carrier your local Tristan representative and Tristan NOTE KEEP THE SHIPPING CRATES UNTIL THE SYSTEM IS FULLY OPERATIONAL If the system or any part must be returned to Tristan the original crates must be used to properly pack the system and avoid shipping damage If the crates have been discarded it is the responsibility of the user to supply equivalent crating to ensure safe return of the shipped items CAUTION THE DEWAR Figure 2
128. the above Model 5700 Biosusceptometer page 4 of 76 Software is provided for setup control and collecting data including patient motion and is written in National Instrument Lab Windows CVI application language An on line analysis routine gives a 1 approximation to the susceptibility It is assumed that final data analysis will take place off line from the system computer which will be dedicated to system setup control and data collection Data collection will allow specific patient information to be recorded in a data file in addition to multiple patient measurements The header block will contain the SQUID electronics and other system information as required to define the experimental setup The SQUID output is voltage both channels and vertical position The data file must be post processed by the user to complete the analysis of liver iron content It should be noted that liver location and depth are important parameters in calculating the iron concentration Fe 1 8 2 The SQUID Detection System amp Electronics e Three channel iMAG LTS SQUID Electronics model iMC 303 SQUID control electronics three model iFL 301 H flux locked loops three model CC 6 fiber optic composite cables and three model LSQ 20M niobium dc SQUID sensors e Model BMD 35M liquid helium dewar with detection coils SQUIDs and superconducting magnet system integrated into the vacuum section Liquid helium level detector on insert to helium storage regio
129. the magnet 3 2 1 4 The magnet current must be driven through the currents leads only These leads are connected with large bolts at the top of the dewar As these leads carry significant currents 10 A do not allow them to be shorted grounded or touched 4 1 6 Magnet Field Plots Figure 4 4 shows the on axis field strength of the magnetic as a function of distance beneath the tail section of the dewar It should be noted that the 5 gauss line is about 14 cm 5 2 below the dewar tail Model 5700 Biosusceptometer page 29 of 76 0 cm 2cm 4cm 6 cm 8 cm 10cm 12cm Distance Beneath Dewar Tail Figure 4 4 Magnetic Field Profile 5 Principle of the clinical method BLS The noninvasive method of Biomagnetic Liver Susceptometry BLS exploits different effects of superconductivity Magnetic fields of 0 20 millitesla within the body tissue generated by an external superconducting field magnet within the instrument are measured by means of a SQUID magnetometer SQUIDs are highly sensitive to the magnetic flux generated by moving a patient within the magnetic field thus allowing the measurement of extremely small magnetic fields changes in the range of 10 to 10 Tesla For comparison the magnetic field of the earth is 5 10 T the magnetic field generated by the heart the cardiomagnetic field is a million times weaker 5 10 T 5 The in vivo liver iron concentration of large near surface organs can be measured by means
130. the preliminary curvature of the thorax as assessed by aid of the thorax radius ruler In a 2 approximation model the liver iron concentration and the magnetic thorax susceptibility are calculated by a multiple regression fit procedure e Inal step a simultaneous fit of liver iron concentration cre and magnetic thorax tissue susceptibility Xtissue could be performed in all detector channels A B and C independently e Derive a reasonable mean Xtissue from detector B only most sensitive to near field tissue in the Ist step otherwise take the BMI derived Xtissue from the online analysis and fit for cre and error terms r far field contributions and or model deviations in all detector channels A B and C independently e Ina 3rd step take the mean error terms from step 2 and fit for BS 6 but ua ol If this fails repeat step 2 but with fixed di Be dte This results in a final iron concentration value with an estimation of the standard deviation from the variation seen in steps 1 3 with respect to systematic errors mainly from the assessment of the magnetic thorax tissue contribution In the case of final analysis for spleens Xtissue 1s derived from biosusceptometry of the liver and the spleen iron concentration is fitted as in step 3 however with Bs 7 2 Precision of SQUID biosusceptometry The absolute error of the organ iron concentration results from the systematic imprecision of 1 the skin liver dist
131. tup re IRQ and addresses okckck ck ck ck ck ck ck ck kk kk kk kk SYSTEM SUMMARY kk ckckck ck ck ckck c kck ck kck kk k kk Windows version 4 10 2222 Computer Name Dell System BUS Type ISA BIOS Name Phoenix BIOS Date 08 30 01 BIOS Version Phoenix ROM BIOS PLUS Version 1 10 A08 Machine Type IBM PC AT Processor Vendor GenuineIntel Processor Type x86 Family 6 Model 8 Stepping 6 Math Co processor Present Registered Owner Paul Harmatz Registered Company kck ck ck ck ck ck ck ck ck kk kk kk kk IRQ SUMMARY Okck ck ck ck ck ck ck ck ck kk kk kk kk IRO Usage Summary 00 System timer 01 Standard 101 102 Key or Microsoft Natural Keyboard 02 Programmable interrupt controller 03 Communications Port COM2 04 Communications Port COMI1 05 3Com 3C920 Integrated Fast Ethernet Controller 3C905C TX Compatible 05 ACPI IRQ Holder for PCI IRQ Steering 05 PCI 6031E 06 Standard Floppy Disk Controller 07 ECP Printer Port LPT1 08 System CMOS real time clock 09 Intel R 810e Chipset Graphics Driver DC133 FSB133 4 11 01 1361 09 SCI IRQ used by ACPI bus Model 5700 Biosusceptometer page 66 of 76 L VO ACPI IRQ Holder for PCI IRQ Steering 09 XPERT 98 PCI English 0 ACPI IRQ Holder for PCI IRQ Steering O Intel r 82801AA SMBus Controller 0 PCI 6025E 1 N I PCI 232 4 Isolated Communications Port COM7 1 ACPI IRQ Holder for PCI IRQ Steering 1
132. ubstances Leak testing solutions should be selected carefully to avoid mixtures that can leave a residue that is combustible When combustible type foam insulation is used it should be carefully applied to reduce the possibility of exposure to oxygen enriched liquid that could upon impact cause explosive burning of the foam Model 5700 Biosusceptometer page 21 of 76 Pressure Relief Devices Must Be Adeguately Sized While most cryogenic liquids require considerable heat for evaporation liquid helium has a very low latent heat of vaporization Consequently it evaporates very rapidly when heat is introduced or when liquid helium is first transferred into warm or partially cooled equipment Even minor deterioration of the vacuum in the helium container can result in significant evaporation Pressure relief devices for liquid helium equipment must therefore be of adequate capacity to release helium vapor resulting from such heat inputs and thus prevent hazard due to excessive pressure This system has been designed to safely vent the evolving helium gas in the event of any reasonable failure mode WARNING DO NOT MAKE ANY MODIFICATIONS TO THIS SYSTEM THAT MIGHT AFFECT ITS ABILITY TO VENT HELIUM GAS IN THE EVENT OF AN EMERGENCY SUCH AS LOSS OF VACUUM IN THE DEWAR VACUUM SPACE If transfer lines can be closed off at both ends so that a cryogenic liquid or the related cold gas can become trapped between the closed ends a pressure relief
133. values locator loop voltage should be slightly below the closest distance equivalent voltage and water pressure of 8 kg in the exhalation phase This critical procedure has to be done with the necessary skills in using the 8 way button hand held controller The instrument and the patient will suffer from inexperienced personnel The horizontal measurement position has to be controlled again on the x y screen The vertical position is documented in the biomagnetometer logbook by the locator loop voltage in the exhalation phase and the bed position In smaller children it is recommended to start with measurements versus air first Then use a lower water bag pressure 5 6 kg and try to increase the pressure slowly from one measurement Model 5700 Biosusceptometer page 35 of 76 run to the other Runs with water pressure below 6 kg exhaled state have to be discarded Water pressure recommendations have to be revised for the smaller pediatric water bag 6 2 8 Execution of biomagnetometer measurements by process control and data acquisition with LabWindows CVI program In the starting position the x y position is controlled a final time when passing the Locator Loop screen No displacement gt 0 5 cm should be tolerated The software is then switched to the 5 trace screen mode of the Chart Recorder display and the pressure trace is observed for inhalation and exhalation oscillations Mou veen Figure 6 5 Main Cons

Ferritometer® Biomagnetic Liver Susceptometer

Contents

Download Pdf Manuals

Related Search

Related Contents

Ferritometer&reg; Biomagnetic Liver Susceptometer

Contents

Download Pdf Manuals

Related Search

Related Contents

Ferritometer® Biomagnetic Liver Susceptometer