The Libra Range of UV/Visible Spectrophotometers
Contents
1. Instrument Part number Libra 11 80 2115 15 Tungsten Single beam Libra 12 80 2115 10 Deuterium Single beam tungsten Wavelength range Absorbance range Bandwidth nm A nm 325 999 3 000 to 3 000 5 200 999 3 000 to 3 000 5 Libra 21 Visible and Libra 22 UV Visible Spectrophotometers e Press To Read PTR xenon lamp technology e Reference Beam Compensation RBC e Instrument Performance Validation IPV facility e 8 position sample changer as standard e Rapid System Operation Libra S21 and S22 are simple to use instruments with advanced performance incorporating xenon lamp technology for longer source lifetime and lower maintenance costs A further benefit of this design is optical noise compensation to improve signal to background measurements Instrument Performance Validation IPV is included as standard and will benefit any laboratory that needs to prove the quality of their results the GLP results can be viewed on the display or printed out In addition to measuring absorbance transmittance and concentration they provide a standard curve routine for analyte determination Wavelength scan with zoom absorbance changes with time reaction rate determinations and standard curves can be displayed as graphics and printed out User defined equations can be entered using multi wavelength mode and up to 18 methods can be saved in separate operator folders The instrument can be Part number Instrument2. The Libra Range of UV Visible Soectrophotometers PARTNERS IN SCIENCE olocnrom Biochrom Ltd and UV Visible spectrophotometry Biochrom has been a leading supplier of quality instrumentation to science and industry for more than 30 years Tens of thousands of our analytical instruments have been supplied around the world sold as own label brands through our distribution partners UV Visible Spectrophotometry is a popular analytical technique used in most laboratories for a whole host of applications and Biochrom manufactures well known industry standard products such as WPA Novaspec Ultrospec and GeneQuant UV Visible spectrophotometers Whilst still addressing Life Sciences applications through the powerful distribution arm of GE Healthcare Biochrom has now developed the exciting new Libra range of affordable and easy to use UV Visible spectrophotometers for other market segments With its long experience of manufacturing reliable and proven products you can be sure that the new range of Libra instruments will be built for longevity ease of use and versatility Offering such innovations as Press To Read PTR lamps for reduced cost of ownership Reference Beam Compensation RBC for accurate measurement and Instrument Performance Validation IPV for GLP compliance the Libra Spectrophotometers are worthy additions to the laboratory bench Spectrophotometer selection guide i Instrument parameters Product Lamp hls Optical
3. upgraded for more sophisticated applications as well as data manipulation with Acquire Software and a PC With its large sample compartment and wide range of accessories Libra S21 and S22 are versatile and reliable instruments for use in any laboratory performing general purpose measurements Sample 005 Cell 09 25 Libra 21 80 2115 25 Xenon Reference beam Press to read compensation PTR RBC Libra 22 80 2115 20 Xenon Reference beam Press to read compensation PTR RBC Kinetics Wavelength range Absorbance range Bandwidth nm A nm 325 1100 3 000 to 3 000 3 190 1100 3 000 to 3 000 3 Libra 32 and Libra 32PC UV Visible spectrophotometers e 1 8nm Bandwidth e Unique Press To Read PTR high energy deuterium and tungsten sources e Instrument Performance Validation IPV facility e Rapid scan facility e 8 position sample changer as standard The Libra 32 and 32PC instruments are high performance systems intended for the busy multi user analytical laboratory The instruments are provided with a Qualification and Performance Verification Logbook supplied to keep an ongoing record of instrument performance for GLP purposes Wavescan 417 Unm 0 1604 ges elie Std Curve 0 3 Sample 3 0 2 m 1 14 16 18 20 Concentration 1 108 12 26 enc fe ED 250 400 420 440 460 480 Fiess smur on Sample Wavelength scan Fress ur on Sample g 1718 ces
4. 595 Juv vis Standard curve Libra S32 only e Free standing instrument e Comprehensive on board applications software covering wavelength scan enzyme kinetics standard curve substrate concentration and multi wavelength equation entry and there is the capacity for 50 user definable stored methods e Direct download of results to Excel for archiving using supplied spreadsheet interface software e Provides display and print out information in English German French Italian Spanish or Russian Libra 32PC only e Compact PC based instrument e Supplied with Acquire software and serial cable Part number Lamps Wavelength range Absorbance range Bandwidth nm A nm Libra 32 80 2115 30 Deuterium Reference tungsten beam Press to read compensation PTR RBC Libra S32PC 80 2115 40 Deuterium Reference includes tungsten beam Acquire Press to read compensation software PTR RBC 190 1100 3 000 to 3 000 lt 18 in 0 1 nm steps 190 1100 3 000 to 3 000 lt 1 8 in 0 1 nm steps Libra 35 and Libra 35PC Pharmacopoeia compliant UV Visible spectrophotometers e Pharmacopoeia Compliant e 1nm Bandwidth e Unique Press To Read PTR high energy deuterium and tungsten sources e Instrument Performance Validation IPV facility e Rapid scan facility e 8 position sample changer as standard The Libra 35 and 35PCinstruments are high specification systems with a 1nm bandwidth intended for t
5. Libra S2 and Libra S2B Colorimeters e Designed with student QC and field users in mind e Rugged portable and easy to use e Extremely versatile e Rechargeable battery version available The Libra S2 colorimeter is a small robust easy to use instrument that has been designed with both the student user and field user in mind It is ideal for teaching the principles of science and analysis in schools and secondary education colleges as well as being rugged enough for measurements in for example remote location health clinics where simple diagnostic tests need to be made The instrument surface is designed for ease of cleaning and decontamination Rechargeable batteries are included in the Libra S2B and the system will operate for almost 1 month on a single charge to provide complete portability The instrument measures in Absorbance and Transmission mode as well as in simple kinetics enabling changes in Absorbance over time and reaction rates to be determined readings are taken approx every second It may be used to cover the 400 700 nm wavelength range as it has an integral colour coded rotating wheel containing nm nm filters at 440 470 490 520 550 580 590 and 680nm These are made from coloured gelatin and are encased in glass so that the instrument can be used in tropical conditions A filter is selected by moving the wheel until the required wavelength is displayed in the window above the cell
6. compartment The instrument may be linked via a serial lead to either a serial printer for hardcopy output or to a PC for download of results to spreadsheet It has an analogue output and may also be connected to a chart recorder using a standard 2 x 4 mm socket to output absorbance time data when in kinetics mode Libra S2 80 5000 02 Tungsten mains only Libra S2B 80 5000 03 Tungsten mains and battery operated Filters 440 470 490 520 DSE 22 550 580 590 680 Filters 440 470 490 520 O 40 550 580 590 680 Libra 4 Visible spectrophotometer e Absorbance Transmission Concentration and Rate e Educational experiments and UV Visible tutorial e Analogue output for connection to chart recorder e Grafico PC utility software The Libra 4 visible spectrophotometer is the ideal instrument for education and QC laboratories The instrument is compact lightweight and ergonomically designed for the simpler applications There is a large display for ease of reading plus a very simple user interface for rapid set up and analysis For educational purposes the user manual includes simple experiments for the determination of max extinction coefficient and natural bandwidth plus the construction of a standard curve and the measurement of stray light The Libra S4 measures Absorbance Transmission and concentration as well as being able to output absorbance time plots directly to chart recorder The instrument
7. is delivered with Grafico PC utility software package and a serial lead providing the student with the means to capture print and interpret a wavelength scan from the instrument on a PC the data for the scan or other results may be easily exported from Grafico to Excel Note that Grafico also includes an educational tutorial on UV Visible spectrophotometry The Libra S4 accepts standard 10mm pathlength glass or disposable cuvettes A test tube adapter set is available for 10 12 and 16mm In the event of a spill the cell holder may be removed for cleaning The instrument is delivered with a starter pack of disposable cuvettes Typical scan output viewed using Grafico note that peaks may be labelled A I 1 Tiia Guta Scan 2 Otgereaats Mehram Lid J User Amira Deki 4 Tate Desorption E Date Tene 1512s 17 39 f G kamieni i i No 137 The same scan exported to Excel Bandwidth Instrument Part number Libra 4 80 5000 00 Tungsten Diode array Wavelength range nm Absorbance range A nm 330 800 One 7 Libra S6 Visible spectrophotometer e Flash Scan diode array e Simple menu driven software e Comprehensive 99 method storage e Wavelength scan kinetics and standard curve functionality with full graphics e Grafico PC utility software The Libra S6 visible diode array spectrophotometer has been designed to meet the routine spectroscopy needs of customers requiring a compact light weig
8. system Wavelength Absorbance Bandwidth Stray Light at Comment Range nm Range A nm 340nm T 40 Libra S2 tungsten filters 440 470 490 0 3 1 99 lt 1 at colorimeter for student 520 550 580 filter and field use 590 680 wavelength Libra 4 tungsten diode array 330 800 0 3 2 5 lt 1 T ideal for teaching labs Libra S6 tungsten diode array 330 800 0 3 2 5 lt 1 T ideal for QC labs Libra 11 tungsten single beam 325 999 0 3 3 000 lt 0 05 T ideal for QC labs Libra 12 deuterium tungsten single beam 200 999 0 3 3 000 lt 0 05 T ideal for teaching labs Libra 21 xenon split beam reference beam 325 1100 0 3 3 000 lt 0 05 T laboratory workhorse press to read compensation Libra 22 xenon split beam reference beam 190 1100 0 3 3 000 lt 0 05 T laboratory workhorse press to read compensation Libra 32 S35PC deuterium tungsten split beam reference beam 190 1100 0 3 3 000 lt 0 025 T ideal for analytical labs press to read compensation Libra 35 S35PC deuterium tungsten split beam reference beam 190 1100 0 3 3 000 lt 0 025 T pharmacopoeia press to read compensation compliant All products have safety certifications CE 89 336 EEC EMC directive CE 73 23 EEC LV directive EN 61010 1 IEC1010 1 As part of our policy of continuous instrument development we reserve the right to alter specifications without notice
9. ducts and accessories with performance and reliability guaranteed by over 20 years experience in the field Amongst other technological advances these instruments feature PTR Press To Read capability which dramatically extends the lifetime of the source lamps Microtitre plate readers washers and dispensers SASYS In the food testing clinical biotech and pharmaceutical industries the demand is for ever increasing sample throughput and smaller and smaller volumes This is where the microtitre plate comes into its own and Biochrom offer an excellent range of fast versatile and reliable plate readers with robot friendly designs via its Asys Hitech subsidiary company In addition a range of washers is available with a unique manifold design for minimised residual volumes and digitally controlled aspiration and dispensing pumps for high accuracy and low noise performance To minimize human intervention and possible error there is a growing requirement to dispense low volumes of liquids rapidly accurately and reproducibly Biochrom s liquid dispensers meet these needs exactly with units for two or six any well format microtitre plates and the ability to deliver volumes of liquid down to two microlitres using a non contact delivery technique thereby eliminating cross contamination Gel electrophoresis SCIE PLAS Gel Electrophoresis remains Hoefer one of the most important ners techniques in the life sciences Biochrom
10. e software has folders that can have restricted access on the been developed by scientists for scientists in an ISO network There is also an audit trail facility operator accredited environment and our software actions used in defining and creating results development process is available for external audit if followed by subsequent editing of results or data required Personal computer specification for Acquire software For optimum performance an IBM compatible Pentium or greater personal computer running Microsoft Windows 95 98 2000 NT or XP is required The PC should have a minimum of 32 MB RAM 200 Mb hard disk a CD ROM disk drive a serial mouse installed one free COMMS serial port and VGA graphics Any printer supported by Microsoft Windows 95 98 2000 NT or XP can be used with the PC Contact your supplier for further information Application modules 80 2115 31 Libra 21 22 Instrument control Wavelength scanning 32 S32PC Reaction kinetics Quantification Multi wavelength Time drive S35 S35PC Acquire Lite 80 2112 24 Libra 11 12 Instrument control Wavelength scanning Reaction kinetics Quantification Multi wavelength Time drive Standard food dye experiment Quantification Instrument control 21 CFR part 11 compliant Acquire Software e Compliant software in terms of electronic records and signatures with full password protection e Export of data directly to Excel s
11. he busy multi user laboratory in Pharmaceutical QC Analytical and Research laboratories whose requirements include high performance GLP Q OQ certification test plans and output to LIMS In some cases compliance with 21 CFR part 11 may also be needed With press to read lamp technology lamp life is only consumed during the measurement cycle therefore long term running costs are minimal The on board self test diagnostics for instrument performance validation may be used in conjunction with the Qualification and Performance Verification Logbook provided with the instruments so that an ongoing record of instrument performance over time may be kept for GLP purposes Part number Instrument The Libra S35 is a compact free standing instrument with local control The Libra S35PC requires a PC or laptop and is supplied with Acquire software and a serial cable when used with the optional Acquire CFR software the system is fully Pharmacopoeia compliant Xylene toluene resolution test at 25 C Absorbance 277 Wavelength The diagram shows the effect of bandwidth when the xylene toluene test specified in the Pharmacopoeia is applied to different instruments The absorbance ratio of the peak around 269nm to the trough around 266nm is 2 0 and 1 7 for the Libra S35 and 32 respectively The value for the Libra 35 confirms that it is fully compliant with all the ratios stated in the Pharmacopoeia monographs 80 5000 35 Deuteri
12. ht instrument that is easy to use and which includes farm ore features than similar priced products The Libra S6 measures Absorbance Transmission Absorbance ratio Concentration and Kinetics A large backlit graphical display enables wavelength scans kinetic assays including slope calculation and standard curves to be viewed The instrument is delivered with Grafico PC utility software package and a serial lead to facilitate transfer of results to computer Alternatively graphics may be printed to either the S1000P or the industry standard Seiko DPU 414 printer plus kinetics data may be output to a chart recorder The Libra S6 accepts standard 10mm pathlength glass or disposable cuvettes A test tube adapter set is available for 10 12 and 16mm COD measurements can be made using standard 16mm tubes The cell holder may be removed for cleaning or decontamination Another version of the instrument the Libra S6H is available with a factory fitted electrically heated cell holder for thermostatted measurements at 37 C D Calc 6 1 04 Conen 1792 afe 1 035 A b S o Lime sec 60 Kinetics assay Standard curve Abs 9 165 a 435 nm C e ig zoom out Wavelength scan inetrument Barenuimber Wavelength range Absorbance range Bandwidth nm A nm Libra S6 80 5000 10 Tungsten Diode array 330 800 0 8 2 5 7 Libra S6H 80 5000 11 Tungsten Diode array 330 800 D5 7 with heated cell h
13. older Libra 11 Visible and Libra 12 UV Visible spectrophotometers e High energy optics e Lamp saver mode e Customisable user interface e Automatic system calibration e Wide range of sample handling accessories Libra 11 and 12 address quality control needs in the analytical and industrial laboratory where higher specification and a wider choice of accessories are required The instruments have absorbance transmittance absorbance ratio and factor concentration modes as well as absorbance against time and scanning capabilities The benefits of enhanced software functionality including standard curve mode reaction rate slope calculation multi wavelength equation definition and storage of user defined methods will be useful in the QC laboratory Graphics are displayed and can be printed out for the scan kinetics and standard curve routines The instrument start up menu may be customised by the laboratory manager in order to meet the applications requirements of the laboratory As measurement needs change the menu can be altered accordingly Both Libra 11 and S12 have a 25 pin multi purpose output as standard for output to PC or chart recorder with the appropriate interface In addition it can be used with a parallel output printer Furthermore the instrument can be used in conjunction with Acquire Lite PC based software to expand the capability of the instrument A 3B4 A 0 591 Standard curve
14. preadsheet and Adobe Acrobat e Full audit trail e All the functionality of standard Acquire software including flexible results formatting presentation and extensive on line help Acquire CFR software has the additional application modules and selected features when compared to standard Aquire Provides system administrators with user management capabilities enabling the required security functions to be established CFR administrator 21 CFR part 11 Acquire applications software is for use with the high specification instruments in the Libra range of UV Visible spectrophotometers and these powerful systems are ideal for Analytical QC or Research laboratories that operate within controlled environments It comprises both client and server applications for networked installations and both of these may be installed on one PC if required Asin any 21 CFR part 11 compliant environment it is the responsibility of the end user to have the necessary standard operating procedures SOPs and training in place to ensure that the maximum benefit is obtained from the system It is the CFR Administrator tool that enables the system administrator to set and define access privileges for individual users or user groups in the laboratory The audit trail is always enabled and separate file and application logs are automatically kept when ready methods or data may be signed off by the user using the File gt e signature function Result
15. s may be printed or exported in spreadsheet or very conveniently in Acrobat format Personal computer specification for Acquire CFR software 21 CFR part 11 compliant Acquire software requires a PC or network with one of the following Microsoft Windows operating systems to be installed NT 4 0 with Service Pack 6 2000 with Service Pack 2 or 3 XP with Service Pack 1 Additionally at least one NTFS New Technology Filing System formatted directory must be available in order to use the software note that FAT amp HPFS are not adequate alternatives The computer should have both a free USB port available for the software dongle and a serial port for connection to the spectrophotometer alternatively another USB port used in conjunction with an appropriate USB to serial converter can also be used Application modules Acquire CFR 80 5000 31 Libra 21 S22 Instrument control Wavelength scanning Reaction kinetics 32 532RG Quantification Multi wavelength Time drive CFR administrator S35 S35PC 80 2114 55 Issue 03 UV Visible spectrophotometry UV Visible Spectrophotometry is a fundamental analytical technique and together with suitable sample handling accessories is used in laboratories for absorbance and transmission measurements of samples in all application areas Biochrom using its Novaspec Ultrospec GeneQuant Libra and WPA brand names manufactures an extensive range of attractive UV Visible pro
16. um Reference tungsten beam Press to read compensation PTR RBC Libra 35 Libra S35PC 80 5000 36 Deuterium Reference includes tungsten beam Acquire Press to read compensation software PTR RBC Wavelength range Absorbance range Bandwidth nm A nm 190 1100 3 000 to 3 000 1 0 in 0 1 nm steps 190 1100 3 000 to 3 000 10 in 0 1 nm steps Wavelength scan Reaction kinetics Acquire Software e Comprehensive software for UV Visible e Flexible results formatting and presentation spectrophotometry e Extensive on line help e Audit trail data log facility in all modes of operation e Export to spreadsheet capabilities Acquire software has the following application modules and selected features Instrument control Simulates instrument control panel Wavelength scanning Zoom 1 4 derivative overlay mathematics peak search Reaction kinetics Serial and parallel assays multi wavelength assays Michaelis Menten Quantification Standard curve substrate concentration curve fit load by record append Multi wavelength User defined equation entry Time drive Long term measurements with automatic save multi wavelength To assist with regulatory compliance Acquire manipulation are recorded in the form of a read software has automatic saving of data from the only write protected text file for subsequent spectrophotometer to user specified directories examination by a supervisor Acquir
17. via its Hoefer and Scie Plas sister companies offers a full range of electrophoresis products for analytical and preparative nucleic acid studies and manual DNA sequencing including both horizontal and vertical units together with all appropriate buffers sampling and blotting accessories Amino Acid Analysis Biochrom has been in the field of dedicated Amino Acid Analysis for over 30 years using established ion exchange chromatography to provide rapid specific amino acid analysis for clinical pharmaceutical proteomics food and feedstuff industries These state of the art bench top products feature proven ninhydrin detection technology fully integrated into a complete package utilising the latest graphical software active components in ceramic and PEEK for long life and elimination of contamination and a range of robust ion exchange columns for customised applications If you want to know more about us or our products please get in touch DIOCNro Biochrom Limited 22 Cambridge Science Park Cambridge CB4 OFJ England Tel 44 0 1223 423723 Fax 44 0 1223 420164 Web www biochrom co uk Biochrom is a Harvard Bioscience company Cerificate No 890333
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