ANNEXURE OPEN TENDER FOR SIMULATED MOVING
Contents
1. increment 0 1 ml min Flow rate accuracy 1 or better Flow rate precision less than 0 07 RSD or better Online monitoring system UV Visible Detector with 2 flow cells Wavelength range 190 840 nm Detection Simultaneous up to 4 different wavelengths Light source Deuterium lamp with 2000 hr Accuracy of adjustment 1 nm Reproducibility 0 5 nm Absorbance range 0 to 5 AU Linearity lt 5 up to 1 AU Flow cells In PEEK and or SS from 0 3 2 4 mm path length with temperature control Materials in contact with mobile phase PTFE fused silica PEEK or stainless steel Optional stand alone control display Software to support real time visualization of product peaks quantification and analysis Fraction collector optional Number of fractions Minimum 30 To collect fractions in 15 ml test tubes 30 ml test tubes and 2 ml microfuge tubes Materials of construction for contact parts Acrylic glass borosilicate type I hastelloy Teflon EPDM PEEK FEP PFA or PTFE Software The necessary software for data acquisition controlling all components output display data analyses evaluation reporting storage etc should be quoted The software should be easy to handle and user friendly Software should be straightforward to use 32 64 bit Windows 7 8 based software Standard sample schedule wizard There should be an on line help function Installation and training Installation should be done by the manufac2. ANNEXURE OPEN TENDER FOR SIMULATED MOVING BED SMB OR ANY OTHER MULTI COLUMN CONTINUOUS CHROMATOGRAPHIC SYSTEM PURPOSE Laboratory scale and Pilot scale separation of proteins sugars and other biomolecules SPECIFICATIONS Columns Number of columns Minimum 4 1 column per zone and maximum 8 columns 2 columns per zone for four zones Column Dimensions The system must be able to operate with two or more column sizes Lab scale columns should be in the range 10 mm ID x 250 mm Pilot scale columns should be in the range 25 mm ID x 300 mm Material and packing Stainless Steel SS columns packed with an appropriate matrix resin to allow efficient separation of proteins and sugars Column setup must allow removal of matrix resin from column casing and reloading of fresh resins in the same column Column oven Temperature setting range 4 C 80 C Temperature control precision 0 5 C or better Overheat Protection Maximum temperature protection adjustable from built in alarm and auto shut off of heating control Ports Number of inlet ports 2 for 4 columns and 4 for 8 columns Number of outlet ports 2 for 4 columns and 4 for 8 columns Software must support systematic switch of inlet and outlet ports between columns at timed intervals Pump Dual piston digital pump Flow rate range 0 001 12 ml min or higher Operating pressure At least upto 20 bar Number of pumps 2 for 4 columns and 4 for 8 columns Flow rate
3. give a satisfactory demonstration of the product
4. turer On site training for operation of equipment live demo of a model separation process usage of software and application must be given to the users free of cost Warranty The complete instrument should be under warranty at least for a period of 5 years from the date of installation Additional cost if any for extended warranty may be quoted In case of breakdown during the warranty period a competent service engineer of the supplier should make as many visits as are necessary to rectify the problem and replace the faulty parts without any liability of cost Supplier should ensure to provide all spares required for making the instrument operational Manual One set of operating manual and service manual including detailed drawings and circuit diagrams in English should be provided with the instrument Spare parts The supplier of the instrument must confirm in writing that the spares for the entire instrument will be available for a period of at least ten years after the model of equipment supplied has been phased out For frequently required spares there should be adequate inventory with an Indian agency Others Certifications Documentation CE IQ OQ and PQ System should be compatible with any other detector Supplier should have preferably service available in Chennai Should have supplied to the equipment to IIT Madras or any reputed institution or industry in India reference should be provided and should be able to
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