HAL BRP
Contents
1. 1 21 2 1 25ng mL 2 15 3 10 1 3 4 7070 125 40ng mL 1 25 40ng mL 5 1 N 91 r 0 959 y 0 73x 104 N 44 r 0 924 y 1 06x 0 87 HPLC N 50 r 0 991 y 0 99x 0 602. x 2 1 2 EA EA ED ED 1 1 8 2 8 60 2 37C 48uL 90gL 5 37C 90zL 237 308 gt 660nm 546nm
3. 1 Fowler 3 8 2 Enzyme Donor ED Enzyme Acceptor EA Henderson CEDIA Cloned Enzyme Donor Immunoassay HAL BRP ED EA
4. 2 8 3 4 S 6 7 ED 8 EA ED
5. IgG gt gt 6 2 114 09 4 lt 0 01 4 lt 0 01 4 lt 0 01 1 7 100 1 2 4 4 p
6. 1 Therapeutic window 3 18ng mL 5 9 Therapeutic window 4 0 14 3ng mL 10 4 20ng mL 1 Therapeutic plateau 13ng mL 20 302 HPLC
7. 6 1 mL EA 8B EA 17lug EA 0 47 g ED B ED 35ng B D 1 6mg ED C1 Br
8. 7 5mLx 1 5mLx 1 13 5 Microgenics Corporation 46360 Fremont Boulevard Fremont CA 94538
9. 9 3 1 0 1 1 121C 20 0 1 4
10. lt 0 01 1 5 2 9 1 9 0 01 lt 0 01 lt 0 01 lt 0 01 lt 0 01 lt 0 01 lt 0 01 lt 0 01 lt 0 01 lt 0 01 lt 0 01 0 01 0 01 46 4 0 01 lt 0 01 lt 0 01 lt 0 01 lt 0 01 lt 0 01 lt 0 01 lt 0 01 lt 0 01 4 5 lt 0 01 lt 0 01 0 01 lt 0 01 3 1 2 40ng mL
11. 2 3 1 1 Na Li EDTA Na 2 15 30C 1 2 8C 2 20C 2 1 2 3 4 5 1 000mg dL 66mg dL 1 000mg dL
12. 2 N 146 r 0 928 y 0 83x 0 99 N 56 r 0 881 y 1 06x 0 56 HPLC N 50 r 0 996 y 0 99x 0 36 6 USP Research Diagnostics Incorporation RDT 1 1 HIV HBV HCV 1
13. 2 3 4 5 1 2 8C 2 23 EA 18mL x1 a EA 18mL x1 HAL BRP ED 18mL x1 ED 18mL x1 39 409 1995 57 380 1999 Fowler A Zabin 1 J Biol Chem 253 5521 1978 Henderson D R Friedman S B Harris J D Manning W B Zoccoli M A Clin Chem 32 1637 1986 5 Anders Forsman et al Current therapeutic research 21 396 1977 6 Irl Extein et al Psychopharmacology bulletin 18 156 1982 7 oseph R Maglozzi et al Am J Psychiarty 138 365 1981 8 Sally Guthrie et al Psychopharmacology The Third Generation of Progress 1323 1987 oo Do 9 3 p 58 2000 10 66 2670 1989 11 1
14. ED ED EA EA ED 8 BB 8 CPRG ED EA ED yEA ED EA ED CPRG 2 1 2
15. 0 01 1 7 3 1 2 1 0 01 0 01 0 01 0 01 0 01 lt 0 01 lt 0 01 lt 0 01 lt 0 01 0 01 0 01 0 01 0 01 50 8 0 01 0 01 lt 0 01 lt 0 01 lt 0 01 lt 0 01 lt 0 01 lt 0 01 4 9 0 01 0 01 0 01 0 01 5 6 100 09 4 0 01 4 0 01 4 lt 0 01 1 6 97 5 1 1 4 4 p
16. 7 367 1986 12 1 39 1998 13 Hikida K et al J of Chromatography 495 227 1989 14 Furukori N Y et al Drug Monit 26 336 2004 0120 249 977 FAX 0120 247 477 3 J EA EA ED ED 5 7 5mLx 1 5mLx 1
17. 970884 005 21500AMY00156000 2008 4 5 2006 10 4 42921000 42931000 HAL BRP 1 2 3 4 5
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