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疑似分子鋳型を用いた環境汚染物質の選択的捕捉技術の開発

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1. 2
2. Kit N N MCPA 1 2 p MCPA
3. 2 SPM SPM b 0806 vi
4. dd kat 2 14 benzeneMlog P log P Solute R log P de Toluene CHa 2 46 122 Methyl benzoate COCH 24 2 105 Anisole OCH 2 11 104 Benzene 2 02 100 Benzoic Acid COOH 1 87 93 Nitrobenzene NO5 1 86 92 Benzaldehyde CHO 1 72 85 Acetophenone COCH 1 58 78 96 Phenol OH 1 46 72 Benzyl amine NH 1 12 55 Benzamide CONH gt 0 76 37 b 0806 64 a b MIF FCA AT A CONH2 was COOCH3 LJ L r NH2 OCH3 OcH3 COOH OH COOH s We NAE COCH3 CHO CH
5. tite
6. B 0806 ii 3 1 MASK C HPLC MS
7. EK 2
8. b VOC 50 EDMA VOC chloroform benzene toluene 3 VOC 2 22 PP OF VOC dt VOC chloroform benzene toluene 2 22 chloroform Chl EDS0
9. 2 d GDMA HPLC Dies B 0806 iii e HPLC
10. 9G DMA PEG gel 4G DMA PEG gel PBEG gel PEG gel PEG gel 902 500 PEG DMA SSA 0 30 70 LOI W 50 50 ei A 70 30 2 300 up 200 PR EH Fr 190 A e 0 0 n4 1d d 0 5 10
11. b 0806 68 A Indomethacin standard sample B Blank serum o 5 10 15 20 25 0 5 10 15 20 25 HPLC conditions C Indomethacin spiked sample in serum Column EVA15 spongy monolith 100 mm x 4 6 mm 1 d PEEK column Flow rate 1 0 mL min Mobile phase A 0 1 TFA aq B 0 1 TFA in acetonitrile gradient 2 B 0 1 min 10 B 40 B 1 10 min 80 B 10 15 min Temperature 40 C Injection volume 10 uL Detection UV 254 nm o 5 10 15 20 25 2 38 h FT IR 1237 cm 1736 cm
12. 10ng L ppt HPLC HPLC
13. 2 38 HPLC pose aa es
14. Ble les Ce Cy ee ree 1 2 nbi peii biting giro ilie Mit M pii 2 20 MB TBTA ser te i die toi R MB lt TBTA lt TBTA UL T
15. Solid Phase Extraction SPE SPE MPP CAME ST Y AMICK ANA MTE CAR 2 1a nm 50 200 um 2 APETA b aay Ed D IUe m Wi
16. 20 30 B b ekle BPA BE2 2 0 250 ng L r pini eae 2 0 ng 3 3 BPA 0 18 ng L B2 0 23 ng L C o 2 7c BPA HW BPA 0 86 ng L E2 0 b 0806 11
17. 2 39 EVA25 HYD SCC pyridine EVA25 EVA2S HYD EVA25 HYD SCC A 2 40 EVA25 HYD SCC pyridine EVA25 HYD SCC 9 0 mL 3 5 MPa
18. DEY 6 1 gt 1 Selective Adsorption of Water soluble Ionic Compounds by Interval Immobilization Technique Based on Molecular Imprinting T Kubo Y Tominaga F Watanabe K Kaya K Hosoya Ana Sci 24 1633 1636 2008 7 2 High Throughput On line Preconcentration Using Spongy monol ith Prepared by Pore Templates T Kubo F Watanabe K Kaya K Hosoya Chem Lett 3 7 950 951 20
19. PCB DMSO 2 HPLC
20. b 0806 69 EVA25 HYD EVA HYD SCC min 0 2 4 6 8 10 12 2 39 solutes 1 uridine 2 cytidine 3 pyridine HPLC conditions Flow rate 1 0 mL min Mobile phase methanol water 5 95 v v Temperature 40 C Detection UV 254 nm 4 0 4 0 R 0 973 A 3 0 3 0 H ct 2 0 2 0 e e e E 10 4 1 0 0 0 0 0 1 0 3 0 5 0 7 0 9 0 mL min 2 40 EVA25 HYD SCC pyridine HPLC conditions Column size 100 mm x 4 6 mm 1 d Flow rate 1 0 mL min Mobile phase methanol water 5 95 v v Temperature 40 C Detection UV 254 nm b 0806 70 i EVA25 HYD AC DEA
21. HM 2 1 a EDMA F MAA Gas MIP b
22. 2 PEG PEG 5 CO
23. HPLC EDMA SSA 209 BEBVA BEDMA SSA 20 EVA EDMA 20 EVA WALLT N N dimethylaniline DMA DMA 2 83 x DMA EVA EDMA SSA 20 1 2 3 mmin 2 83 EDMA SSA HPLC conditions Column size 100 mm x 4 6 mm i d Mobile phase methanol 0 1 mM HCl aq 90 10 Detection PDA Temperature 40 C Solutes
24. MS 1 6 SIM BRAC MASK MASK MASK 1 6 E2 BPA 5 g 10 000 MASK JF Bih
25. BVA B 0806 27 3 PCB
26. EDMA PCB 2 d HPLC GDMA
27. EVA 3 adsorption lt gt desorption 30 um 2 3 ZILE C PRO AAT VU y MEOT A V D 0806 30 6
28. PCB PCB 2 gt gt EPA PPCP
29. GDMA D8 VR b 0806 57 15 sil C18 B 15 EDMA 10 r1 Ja 1 0 8 9 g 0 5 m 05 o 9 0 0 x 9 0 o en en S 05 4 0 5 10 1 0 1 5 45 2 0 1 1 1 j 2 0 L L 1 i L j 1 0 2 0 3 0 4 0 5 0 6 0 7 0 10 2 0 30 40 5 0 6 0 7 0 Log P Log P 1 5 GDMA 1 0 0 5 0 0 on 3 05 2 goeg 1 0 94 o 15 2 0 1 5 EVA25 15 lEVA15 re oN CD mn BB Q d Q S 0 5 E 0 5 1 0 1 0 1 5 1 5 2 0 2 0 1 0 2 0 3 0 4 0 5 0 6 0 7 0 1 0 2 0 3 0 4 0 5 0 6 0 7 0 Log Log 15 EVA25 HYD xdi E 10 8 1 0 05 O 0 5 A ax i _ po S 3 gg Q e e A 05 f Oo 0 5 1 0 1 0 A 1 5
30. ZUR 2 0 1s EDMA 1 0 4 0 5 0 0 0 5 Log k 1 0 1 5 2 0 2 5 0 5 1 0 1 5 Log P EVA25 Log k I ut 0 5 0 0 Log P 1 5 2 0 0 5 1 0 Log P 2 32 k Log k Log k 0 5 1 0 1 5 e 2 0 s GDMA 05 _ A AA 0 0 0 5 1 0 2 0 f 2 5 0 5 0 0 0 5 1 0 1 5 Log P 2 0 2 5 _EVA25 HYD 0 0 2 0 amp 2 5 0 5 0 0 0 5 2 0 2 5 HPLC conditions Column size 100 mm x 4 6 mm 1 d Flow rate 1 0 mL min Mobile phase methanol water formic acid 40 60 0 1 v v v Temperature 40 C Detection UV 254 nm e EM benzen EH 0o f lE E Se XE E PR EE I benzene
31. 3 PPCPs PPCP 4
32. 2 l o Zi iA ican a diese neta eet vee ee Mae eee co mV 200 150 I Bi SR S EPA PAHs o D 1 jq qo eT 4 poor 35 3 C WE D e ez n2 Oo ce NO e Non spiked 0 V ee i dabat Mic ARA ARR b 0806 105 E E a p fium nini mg fa ae 9 OOOOO 0000 im
33. z 7 EVA PAHs EVA BEVA25 EVA25
34. BTEA BTBA BTBA PEG gel PEG gel BTEA BTBA VBTMAC NaCl BTEA BTBA BS Rit
35. BB comme on Oe keer b 0806 104 C1 2
36. sulpiride MIP I MIP 2 HPLC SPE I MIP SPE HPLC PPCP SPE HPLC ppt
37. tj triphenylene p terphenyl O m terphenyl o terphenyl EVA25 EVA2S HYD CET EVA15 pE EDMA GDMA Sil ODS 0 0 2 0 4 0 6 0 8 0 10 0 120 140 160 180 2 28 HPLC conditions Column size 100 mm x 4 6 mm 1 d Flow rate 1 0 mL min Mobile phase methanol water 85 15 v v Temperature 40 C Detection UV 254 nm ezT O 2 29 silica Cja go T O
38. HPLC 1 ng L
39. MR 20 24 58 1357 A 24 11 991 20 Be HPLC A BPA 179
40. AM ik mJ 3 at b a y n 2 IE x PE f aa imc 4 X Wig HF o b FO 9 D Less et Wil E oy T T A a c gt mw uw ry P fe EM re 4 Tf 3 are Kha oe Tg 1 SEM DB 0806 26 3 1b X PG AIP
41. 2 27 Tu x
42. EVA b 0806 95 CO 2 81 SEM a EVA EDMA 5 b EVA DVB 5 c EVA gra carb 5 d EVA e EVA EDMA 4Vp 1 f EVA EDMA 4Vp 5 g EVA BDMA 4Vp 20 h i EVA EDMA SSA 20 d MAA 4Vp HPLC pyridine 2 82
43. MTE 25 PERE EVA BPA
44. 2 PPCPs Pharmaceuticals and Personal Care Products polycyclic aromatic hydrocarbon PAH 1 PAHs DED
45. 3 PCB H PCB DMSO DMSO DMSO b 0806 31 PCB DMSOJ ACS OO REE amp LC illl PCB PCB 31 PCB
46. Tes 2 14 000 000 A P25 HE O P25 SC AL 12 000 000 P25 HE TB Wm 10 000 000 e P25 SC AL TB An P25 amp 8 000 000 gt lt E 6 000 000 4 000 000 2 000 000 7 0 MEER ERR 0 10 20 30 40 2 78 Be EEA OD dc STX 27 FAAS E 5 30
47. b 0806 56 EVA25 HYD SIL ODS GDMA min 0 10 20 30 40 2 26 Solutes 1 uracil 2 o terphenyl 3 triphen ylene HPLC conditions Column size 100 mm x 4 6 mm 1 d Flow rate 1 0 mL min Mobile phase methanol water 80 20 v v Temperature 40 C Detection UV 254 nm b A 0B log P 1 log P log k 2 27 log log P
48. 16 1 0 gs 0 7 mmol 2 41 EVA2S HYD AC DEA EVA25S HYD AC DEBA 8 0 mL min
49. ng 7L PAHs B 0806 3 3 1 1 2 A 3 2 2 ee 150 BL 1 1 Dik Concentration Displacement of Flow Line Pump for Mobile Phase LC 20A
50. 500 ppm TBTA 63 2 98 5 TBTA 2 TBTA_ P TBTA_ P TBTA 2 mAU 1500 1 60 mM 500 ppm BTBA 0 92 mM 500 ppm TBTA 1000r Cl C4He 3 N A Po weise ls TBTA 500 54 36 oves di I BTBA 760 66 0 0 25 50 75 100 min 2 63 TBTA P d IIT STX dcSTX IIP dcSTX dcSTX
51. Hise WA 22 2011 11 Al EVA MRR 19 2012 S 42 Att MRS 19 mm 2012425 A 43 MAB 19 2012 5 44 GC MS CI ARRIT 21 2012 7 45 RI 46
52. 1 1 10 ng L b 0806 2 HADLEBLZA DING Enzyme Linked ImmunoSorbent Assay ELISATE Radioimmunoassay RIA 9 GC MS 9 HPLC
53. 3 PPCPs 2 PPCPs b 0806 32 PPCPs 1 MCPA MCPA MCPA MCPA LT
54. 2 HPLC a SOE AI LIE ise nou 2H 2g FE ReH E Sage OC E TL cerN NUCH A FIJ SO C4Hg 3N A N C4Hg 303S A B 0806 33 5
55. a JC r 0 9991 0 9999 RSD 0 2 12 7 a re B 0806 17 0 1 2 8 ng L 0 4 9 11 ng L 1 0 ng L 5 0 ng L 5 1 50 mL 100 PAHs 5 MASK ENV 9 GE
56. VOC VOC VOC Bre UT ARN UU vm eS R NI 3 VOC chloroform benzene toluene 1 1 1 v v v 3 VOC methanol 10 mL benzene toluene HPLC benzene toluene chloroform 21 2 1 ii Gas MIP VOC toluene pyridine HERR toluene pyridine 1 1 vvy
57. 0 99 i PEG PEG PEG
58. MAm 61 2012 9 17 SK MAR 61 ER 2012 9 18 32 2012 11 19 Mim 23 2012 11 20 HP PCB NFS MAR 23 2012 11 21 23 2012 11 22 PEG
59. PCB PCB 2 lt gt gt BEPA PPCP
60. VOC 2 EVA
61. Blog P CRRA Olog log b 0806 iv Gas MIP b HPLC SPM SPM
62. 59 2010 9 10 d ETC UR Me 21 BE 2010 10 11 MR x 21 BE 2010 10 12 PCB MAR 18 2011 5 13 60 FR 2011 9 B 0806 ix 14 MAR 60 2011 9 15 AM 2012 8 16
63. DVB EDMA PVS DVB BDMA PCB BDMA PCB b 0806 76 2 15 4 pm 0O 11ij il of Of o y jo jo 5 pes a9 E39 9 9 3 3 T3 3 5 pms 0 15 1 0 J0 27 20 1 1 ol L5 e qmi gu Toe 6 ps a of a tt of a PT oP 1 1 9 mor op 3m qo 9 3 3 9 31 9 93 6 pe 31 17 3 op 0 9 3 psm 0 1 1 o of of 1 1 f 0 6 meo 1 0 1 1 0 02 1 1 1 oi 6 pm 0 1 1 ilOlOolililil il ol 6 p 1 il il OOolOolilil 0 yo mz 3 9753 33 4193 6 pmo 0 tt ililOololilil 1 E Ia qu EE Se LT ge a a oe a 8 ma 1 lil 1 ct Pl oP Pt Pa tf o 8 os 0 1 1 1 1J 0 ep Pa t Ij 9 js 1 1 tT 1J0 1 1 1 t Ij O 25 10 15 10 8 15 10 8 15 15 20 10 20 10 15 10
64. SEM x 4 6 mm HPLC i PEG DMA SSA PEG PEG PEG 4 1 MASK
65. bx L
66. 2 41 flow rate 8 0 mL min 0 1 m in 0 B 100 B 1 2 25 min flow rate 4 0 mL min gradient O96B 0 1 min 096B 100 B 1 4 5 min flow rate 1 0 mL min gradient 0 B 0 1 min 096B 100 B 1 18 min 0 5 10 15 20 2 41 EVA2S HYD AC DBA HPLC condition Column EVA25 HYD AC DEA 50 mm x 4 6 mm 1 d Flow rate 2 0 mL min Mobile phase A 5 0 mM tris HCl pH 9 0 B 5 0 mM tris HCl pH 9 0 0 5 M NaCl Temperature 40 C Detection UV 220 nm Solute 1 ovalbumin 2 ribonuclease A 3 Lysozyme 3 PCB M PCB a 4 DVB 3
67. b 0806 61 silica Cig pen 2 1 Hg 2x0 0 37 P OOZ Be RATAN ARY T T IAN 10 addidi a ON ti FUME NR min min 20 2 37 1 ribonuclease A 2 cytochrome C 3 chymotrypsinogen 4 conalbumin HPLC conditions Column spongy monolith column 100 mm x 4 6 mm 1 d Flow rate 1 0 mL min Mobile phase A 0 1 TFA aq B 0 1 TFA in acetonitrile Gradient 5 60 B for 10 min Temperature 40 C Detection UV 280 nm
68. HPLC p RDS HPLC MIP I MIP I MS ppt ng L COMB SPE HPLC MS 10 ppt b 0806 v
69. DRERI 1 2 BAIT SVS 354 AIK 2 1 1
70. BAIL VBTMAC PEG gel pH pH 1 0 R 0 9 A 08 07 06 a 05 04 03 iG e Na 02i m HCI 01 r A NaOH 0 0 VE gt H oT Hi 0 0 001 0 002 0 003 0 004 0 005 M 2 88 Hi Hb 89 SSA BS NaCl PEG gel
71. ETE MITT STET T ERI TER a 4 7 mm i d EVA b SEM x 500 um W 2 2 SEM 2
72. BaP 2 35 BaP 10 ug L 10 30 mL BaP mAU x10 benzo a pyrene 0 0 2 5 5 0 7 5 10 0 12 5 min 2 35 benzolalpyrene HPLC conditions Column ODS 100 mm x 4 6 mm i d Pretreatment column EVA spongy monolith 50 mm x 4 6 mm 1 d Flow rate 1 0 mL min Mobile phase 80 acetonitrile Temperature 40 C Detection UV 254 nm Concentrate flow rate 2 5 mL min Concentrate time 12 min Sample 10 fold diluted chikusaku eki aqueous sample bamboo pyroligneous acid B 0806 66 PAHs ENE SN II soul 0 ENG RS TUN SiS
73. PCB PCB DMSO 2 1 DMSO 2 1 PCB H UR 1974 61 10 49 UP MEISE OE sre sep ay rE cpp 9 With Glee YA E l
74. b 0806 25 1 1 1 TRAUB HO 2 BPA E2 PAHs
75. 1 1 228 41748 93 mdp 410 mdp 430 MASK ENV 4 mm I D X 10 mmL 4 mm ID X30 mmL 2 4 6 mm
76. C c PCB lt PCB lt 2 2 2 4 ADVN 3 PMB 1 3 DB 1 3 5 TB DVB GDMA EDMA CMS PVS 3 2 RIX DMSO
77. 2010 3 ARGH LC talk 2013 2 lt gt 1 Novel hydrophilic polymer monolith for capillary chromatography Takuya Kubo Naomi Kimura Ken Hosoya Kunimitsu Kaya 32th ISCC Riva Del Garda Italy May 2008 Keynote Lecture 2 Effective pretreatment for saxitoxins using novel adsorption medium prepared by interval immobilization technique Takuya Kubo Yuichi Tominaga Kunimitsu Kaya Ken Hosoya 21st PREP San Jose USA June 2008 Poster 3 4 5 6 7 8 9 b 0806 110 Effective molecular recognition for 10nic compounds by the interval immobilization technique Takuya Kubo Yuichi Tominaga Ken Hosoya MIP 2008 Kobe Japan September 2008 Oral Novel hydrophilic polymer monolith for liquid chromatography Takuya Kubo Naomi Kimura Ken Hosoya EAS 2008 Somerset USA November 2008 Poster High throughput on line concentration by novel separation media named Spongy monolith Takuya Kubo Fuminori Watanabe Ken Hosoya HPLC2008 Kyoto Kyoto Japan December 2008 Oral Selective concentration of water soluble natural toxins using polymer based materials Takuya Kubo Ken Hosoya 6th WATER DYNAMICS Sendai Japan March 2009 Poster
78. h SEM EVA EVA EVA EVA THY MAA 4Vp MAA 4Vp A
79. EVA dyvinylbenzene DVB 6
80. methanol 70 A PEG gel 67 PEG DMA PEG gel PEG DMA 60 90 50 E m Sp 70 p e D 40 s 60 a gt uM 50 ES S i RN HR 40 NP Sa Ey ik Et EL 46 20 SSA gel 10 li VBTMAC gel 0 0 5 10 15 20 25 0 3 0 4 0 5 0 6 0 7 2 86 BdQ 87 b 0806 99 c NaCl HCl NaOH PEG gel pH 2 88 PEG gel PEG gl PEG gel
81. BRR BOT Igne dh ERR f TA Dit EA Be tee pr ec UB 1 3 00 1 14 PAH Naphtharene V PAH Dibenz a h anthracene 3 4 5 6 7 e Dibenzola hlanthoracene s Naphtharene 1 14 ARERI ES Dibenz a h anthracene Naphtharene 1 13 5 PAHs THY hb BB IE ee tel ee
82. P25 MB STXs h EDMA MAA 4 4Vp EDMA SSA TBA 70 C EVA 150 C 130 C 4 8 mm
83. 76 MB TO P25 210 TiO b 0806 91 P25 A5 25 m P25 A P25 HE A P25 HE e P25 SC AL e P25 SC AL 0 20 3 B B 5 m 15 EX HE aR jo S 10 G ea ea gt gt
84. 1 7 mL CCL 1000 uL Br 10 uL Cont P 0 1 0 gs CHU DS RR CCl 20 EARL 415 nm Cont P L HPLC TBTA P methanol 1 0 M NaCl aq 1 1 v v 70 methanol aq HPLC HPLC conditions Column size 100 mm x 4 6 mm 1 d Flow rate 0 2 mL min Mobile phase methanol 0 4 M NaCl aq 70 30 Temperature 30 C Concentration of template molecule 500 ppm Detection PDA g 0 25 500 uM TBTA 70 methanol ag TBTA
85. 06 ng 5 4 RSD n 5 3 1 2 TEZ oA BE E AW RA BUNSEN KAGAKU VO 58 No4 pp 2903 209 2000 2 Y Watabe T Kubo T Nishikawa T Fujita K Kaya K Hosoya J Chromatogr A 1120 2006 252 250 1 CHEMCOMAS ENW Cat No Sci ER AE mea RE en 410 zwxvm Sum 4mmidx10mmL 52000 Westm ream xwavm Sun 4mmiqx30mml Ysooo Mass zuxvm muxs2vv r Sun 2mis x 105m xxu Sun 2mmia 30mm Yssooo vasos Z BoKteKUY FR E Cat No Hee LE i L mdp 410 Sum 4mmidx10mmL 37 000 ahok mdp 430 5um 4mmidx30mmL
86. 2 68 pH pK 2 69 C SEV SAT REAVER ROME Ose OCC COmNIODIUS RO I 3 BLANK APB p 2 TBTA P BTAB P 90 min 90 min Aniline 1 APB
87. STX STX STX dcSTX f EDMA EDMA 5 25 g TBA 2 mmol 4 4 BTAB 1 mmol gt SSA MIP 1 NIP I HPLC g
88. 2 PBG gel EDA 25 mM EDA 2 b 0806 101 FU HCI EDA 2 EDA 2 PEG gel 00 0 9 90 Lus s e 5 mM s 80 E 25 mM gt 76 B 0 7 100 mM n Q 60 nA 0 6 Q 50 e5mM EB 95 205 40 825 mM IR K 30 4100 mM X 0 4 Be 20 B 0 3 E 02 10 e 0 0 1 0 2 0 5 10 15 20 25 HC1 mL 2 90 pH EDA 91 EDA SSA gel d PEG ge
89. EVA 130 C SPM SPM EVA25 HYD 6 M NaOH 70 C 24 SPM EVA25 HYD SC EVA25 HYD 24 SPM EVA HYD DEA EVA25 HYD 48 60 C 72 15 25 SPM EVA15 EVA25 PE EDMA GDMA C 4 6 mm 100 mm HPLC SPM
90. 30 MB 0 30 MB 30 MB MB UV MB MB P25 SC AL gt P25 HE gt P25 UV 30 MB 30 MB DIC MB 210 MB MB MB 210 30 MB
91. Sa 13 http www an shimadzu co jp 3212 11211 30AIT TLL CRRA B 0806 4014 ESEEL E RUT BBES REOR Uf ER HT BE SE SENEDE x Be RE Hy HERR ASH LEES Solar Lu 3 25 2 ee J 3 http www chemcoplus co 1p cn7 p2154 html 87 6 ng L NN P stings ap m Intensity 10 0 BM 200 20 Time min
92. MS 10 ppt parts per trillion ng L HPLC 7 X
93. PEG gel PEG gel PBG gel BS 97 BDS 100 BTEA 92 BTBA 85 TBTA 40 Z PEG gel EH8OTBTA2 SEI b 0806 100 PEG gel NaCl PEG gel PEG gel PEG gel PEG gel 1 0 a 0 9 f 0 8 Ht e E 0 7 1 ru F3 e xa 0 6 a oO e oo A e k 0 5 BS TA A m 4 o BDS A A R 0 A BTEA A 0 3 A BTBA
94. RIC SPM a SPM fr SPM m c PCB PCB EDMA DMSO EDMA PCB
95. acetonitrile L 20 HPLC B 0806 36 Dy Cee WP 4 6 mm S BA ET E amp D Cem 2 8 d HPLC 4 6 mm 100 mm EVA2S 25 EVA EVA1S 15 EVA EVA25 HYD EVA25 PE AEF FE CAH FAY EDMA EDMA GDMA GDMA
96. 1 10 1 11 mV 1000 750 1 500 ES WT FE RmW Galt bb potest pure ded IST 250 55 16 0 5 1 0 15 n0 nin 2 3 4m 6 0 00 50 4100 150 200 250 min 1 10 PAHs mV 100 75 50 1 2 25 3 00 50 4100 15 0 200 0 0 min 1 11 PAHs 1 11 1 10 PAHs PAHS
97. AMA 61 2012 9 AT MRE KAYE 61 2012 9 H 48 Mingdi Yan ARIE 56 2012 10H nsi b 0806 117 49 32 2012 11 WO 50 KEKAL Z AME LETT AOWR TARPS ITTY v R RY SHR OB ARR 21 20124211 A 51 MRR 21 2012 11 52 MARR 23 2012 11
98. 1 4 150 2 0 MPa 1 0 MPa m 20 14 12 N c3 amp 10 MASK Z og R H pw 4 2 Lap 50 100 150 200 e 1 4 130 7 5 L 2 ZR VERE MASK 1 5 b 0806 9 Uv 275 nm EMVLMASK 0 2 4 6 8 10 12 14 16 18 20 1
99. PAHs PAHs 1 15 PAHs 30ng L 1 2 X 60 ng L 3 6 10 14 300 ng L 1 16 mV 200 150 i 100 3 fin E 15 0 l n bd 00 50 4100 4150 200 4250 30 0 min SMOD 1 16 Bp k 0 RRL eric PAH 30 300 ng L PAHs ng L 2 13 70 98
100. VOC Gas MIP 0 43 p E Chl ED50 0 41 Ben ED50 og 039 Tol EDS0 yu 0 37 EX 035 3x 0 33 E 031 0 29 0 27 0 25 chloroform benzene toluene 2 23 VOCs c pyridine MAA Gas MIP pyridine toluene 2 24 MAA pyridine MAA pyridine Cont P
101. 4 tributylammonium methyl benzyltributylammonium chloride TBTA or 4 4 bis tributylammoniummetyl chloride biphen yl BTAB c p styrene sulfonic acid SSA chloroform TBTA SSA BTAB SSA benzyltributylammonium chloride BTBA SSA tetrabutylammonium chloride TBA SSA 4 d Interval immobilization polymer IIP Cont P L EDMA chloroform ADVN methanol Cont P methanol 64 VC 24 methanol IIP C e
102. BET IIP IIP TAL HPLC 1 BTBA IIP 56 IP 2 TBTA TBTA TBTA_ P BTAB BTAB BTAB P TBTA P BTAB_ P 18 2 18 Acetone BTBA TBTA BTAB Cont P 4 54 6 56 3 80 6 56 TBA P 4 40 Tale 4 46 8 16 BTBA P 4 74 8 10 4 70 9 58 TBTA P 4 62 8 88 8 34 16 00 BTAB P 4 66 9 02 6 68 18 82 HPLC conditions Column size 150 mm x 4 6 mm i d Flow rate 0 5 mL min Mobile phase
103. 2 48 77 169 4 49 DVB non ortho PCB LA 1 1 LPS TEAR V7 10 15 20 2 48 DVB non ortho PBC b 0806 74 DVB 4 non PCB 90 NE vow ALY x LAWN pp ANS 10 10 2 49 DVB 4 non ortho PBC EDMA 30 EDMA fth EDMA non ortho PCB AA AA AA S
104. BLT MS 1 3 2 A 17 8 PAHs ng L HPLC 25 2 1 a
105. PPCPs b 0806 28 PPCPs PPCPs PPCPs 2
106. 60 Torr 48 VOC methanol 1 0 mL HPLC pyridine toluene benzene toluene pyridine HPLC HPLC Condition Column Mightysil RP 18 GP 150 x 4 6 mm 1 d Flow rate 0 5 mL min Mobile phase 60 acetonitrile aq Temperature 40 C Injection volume 1 0 uL Detection photo diode array PDA 2 de Aa eT PAD SB EVA 21 wt pentaerythritol 64 wt 15 wt poly oxyethylene oxypropylene triol 130 C CARMEL ME 4 7 mm 50 methanol 2 6 b 0806 35 poly ethylene co vinyl acetate EVA pentaerythritol Peth polymer pore template 25 75 v v SHAME M 2 6 EVA
107. MAR 23 2012 11 7 XE 1 mL 2 3 48 4 he 5 R amp D b 0806 1 B 0806 1 x
108. B 0806 71 DVB DVB 42 DVB xylene PCB 90 90 30 LEN 10 JANS NM mtt 10 0 5 2 42 DVB xylene PBC DVB 4 PCB Ed2 43 ae DVD 4 PCB 2 43 DVB 4 PBC GDMA CMS GDMA 44 GDMA b 0806 72 GDMA PCB
109. DMSO H Ed DEATH M H m LRGC ECD GC ECD LRGC ECD GC ECD GC HRMS oe GCLRMS GCMS DMSO 2 1 PPCPs PPCPs
110. BPA 1 3 1 3 BPA 97 1 4 RSD 0 09 ng L R 0 9999 n 6 10 ng 1 8 b 0806 12 BPA 10 ng L 1 8 BPA 5 0 ng 1 9 25 my 20 15 10 BPA 5 ng L 0 5 10 15 20 n 1 9 BPA 5 0 ng L
111. silica C e T O silica Cja go T O aT O 15 C b 0806 59 Sil C18 S 60 C 040 C GDMA B 15 C EDMA PE Sv F u EVA15 EVA25 HYD EVA25 0 0 3 0 6 0 9 0 12 0 15 0 a T O 2 29 HPLC conditions Column size 100 mm x 4 6 mm 1 d Flow rate 1 0 mL min Mobile phase methanol water 85 15 v v Temperature 40 C Detection UV 254 nm EVA 30 silica Cja
112. invents amp PE LA MBE F AME i A A A te 1 0 mL min 20 SS 20 mL min 1 5 10 mL 50 30 acetonitrile 5 PAHs 1 15 10 ng L 1 2 20 ng L 3 6 10 14 X 100 ng L 3 B 0806 16 mV 11 75 Bon 12 50 2d 10 1 3 7 13 25 6 14 VN aL 00 50 4100 415 0 200 425 0 30 0 min 1 15 30 acetonitrile 5 fA PAHs acetonitrile
113. 15 P25 90 EtOH aq P25 P25 3 P25 SC 120 YC 60 ALS 34 7 mg 2 39x10 mol TBTA 65 3 mg 1 20x10 mol 120 P25 SC 1 0 g 67 methanol aq 300 mL 10 P25 SC MLE ADVN 0 10 g 70 C 24 120 C 60 P25 SC AL TB P25 SC AL c HESA 0 11 g 0 74 mmol TBTA 0 20 g 0 37 mmol
114. 14 azure C UVBGEE IERI MEE amp 72 A CO dv C Z 98 RE OD MB C N MB MB b 0806 92 UV irradiation 0 min Inten x1 000 000 284 05 4 0 0 min 3 0 2 0 1 0 270 05 0 0 T T T l T 50 100 150 200 250 m z UV irradiation 60 min 284 05 Inten x100 000 270 0 5 0 25 256 00 0 0 i l L Lid Lh 50 100 150 200 250 m z UV irradiation 120 min Inten x100 000 256 05 2 0 270 05 E 242 0 1 0 284 05 0 5 0 0 Loa fis Tes i csi Huu 5s L 50 100 150 200 250 m z 2 77 MS c
115. 2 M MASK BNV 5 1 tt xe 2
116. A 2011 5 34 60 2011 9 35 MERR WE 60 2011 9 36 WU 33 2011 11 37 make MARR 22 2011 11 38 MAR 22 2011 11 b 0806 116 39 spongy monolith MIRE MAR 22 2011 4E 11 RS 40
117. ie EDMA SSA EDMA 13 0 g SSA TBA 2 1 g 2 11 meq g EDMA MAA EDMA 4Vp EDMA SSA 0 38 0 12 d BEVA EVA pentaerythritol 150 C 130 C 4 8 mm methanol L SEM 4 6 mm HPLC HPLC 6 a HOERA URI Poly ethylene glycol dimethacrylate PEBG DMA Wakayama Japan
118. 2 3 ADVN xylene or PMB DVB or EDMA or GDMA CMS 24 WL acetone 65 C WEL methanol acetone 70 C 106 212 mm 2 3 b l xylene ml PMB ml monomer ml CMS ml DVB base4 8 0 4 0 4 0 EDMA 4 75 4 0 0 75 GDMA 4 75 ES 4 0 0 75 DVB PMB 4 59 4 0 1 0 60 C ADVN mg 160 95 94 100 DMSO Nal 80 C 13 1 thiophenol 30 methanol ag KOH aq 1 0 mol L 10 14 2 Nal SH 1 0 eq NaOH B Y 3096 MeOH aq RT 2 13 1 2 14 2
119. a EV 74 0 14 0 128 013 oO Bon K 0 11 010 0 094 N 0 09 A 008 0 07 P25 HE P25 SC AL 2 74 BATT Uv FEDERE 4 2 V RA E b Methylene blue methylene blue MB 20 ppm MB UVE MB 2 75 0 MB
120. 1 0 ng L FRET 5l62452o f 7 1 B AR 2 B DRA 3 4 Hh 5 6 7 v LC MS 1 7 0 5 ng L yohimbin 0 34 ng L dar q 09 alprenol 0 26 ng L E doxepin 0 16 ng L TE imipramin 0 15 ng L 225000 amitriptyline 0 31 ng L 200000 dibcaine 0 49 ng L ipae qh isopropylantipyrine 0 21 ng L viii D ke Hn lt detection limit in parentheses 75000 each10 ng L added in river water 25000 1 0 25 5 0 7 5 100 12 5 1 7 3
121. VG SRS RICIIR LIER O ATR V Vy 5 Su 2 6 d 15 mLO polypropylene tube 119 mm x 14 7 mm i d RRA 30 HR pyrex tube 60 mm x 9 0 mmi d UV 365 nm 3 HA protein imprinted gel Pl gel 1 0 mm PI gel methanol 2 1 0 M NaCl aq f Port il amp FO lysozyme c UV Vis 280 nm 1ysozyme WFR WZC UV lysozyme trypsin avidin 280 nm cytochrome c 409 nm 4 1 1 a
122. b 0806 14 TCU HII 27 5 0 I e EEMI AAE Dibenz a h anthracene 100 ng L 10 20 30 409600 5 A acetonitrile 1 12 30 20 40 60 1 12 acetonitrile Dibenz a h anthoracene 15 PHAs fS RIZ 30 v v acetonitrile 1 13 1 11 CHALUTWH PAHs HORA 1 11
123. 30 EVA MODIS WaT ACT B 0806 60 PUL d b 2 31 Silica Cja 1og 1og P benzene toluene 2 31 Silica Cj
124. 2 4 non ortho PCB 2 6 PCB non ortho 8 3 4 4 5 Tetrachlorobiphenyl 77 3 3 4 4 Tetrachlorobiphenyl 126 3 3 4 4 5 Pentachlorobiphenyl 169 3 3 4 4 5 5 Hexachlorobiphenyl mono ortho 123 2 3 4 4 5 Pentachlorobiphenyl 118 2 3 4 4 5 Pentachlorobiphenyl 105 2 3 3 4 4 Pentachlorobiphenyl 114 2 3 4 4 5 Pentachlorobiphenyl 167 2 3 3 4 4 5 Hexachlorobiphenyl 156 2 3 3 4 4 5 Hexachlorobiphen yl 157 2 3 3 4 4 5 5 Hexachlorobiphenyl 189 2 3 3 4 4 5 5 Heptachlorobiphenyl 3 2 2 g 4 4 CDn CDs 2 4 2 1 2
125. Cont P Cont P 2 62 Cont P Br B 0806 82 0 975 Br 0 Br EL Cont P Cont P 1 97x10 mol g do 0 19 5 13 14 A TBTA SSA 27 5 BTAB SSA 31 0 A ContP b IIP
126. 20 2009 11 5 HPLC emia EA MAR 59 2010 9 6 A HPLC Herp tise MEA 60 2011 9 7 HPLC MAR 22 2011 11 2011 8 HPLC PHA MAR 23 Ig 20124211 9 HPLC FUR MARR 20 2012 b 0806 21
127. b 300 mL 6 0 M NaOH aq 150 mL methanol 150 mL 3 65 C 24 30 methanol 50 methanol 12 methanol L BEVA HYD 2 7 O b di OH O NaOH p O H20 AL m n 2 7 EVA c 2 8 4 8 mm methanol FM 7 2 7 OR im x N46 mm
128. 2 14 benzene log log log P some log P Benzene 2 33 B 0806 63 IR AEG LOS keon log eamus ER CVS KH Pe Be boa 6 eOe eA aA benzene 2 33b log k soe log K penzen 1og P log P somre log P Benzene 2 33a 1og P 2 bb ER
129. Bq 2 19 SSA 65 C C24 methanol 7 c HPLC HPLC 100 mm x 4 6 mm i d L methanol 1 0 M NaCl D 0806 46 aq 50 50 v v 50 methanol aq NaCl HPLC 7 AR LICH Y VAL OMAK CMS EDMA TBA 42 99 mg 0 10 mmol ADVN 20g TBTA 42 48 mg 0 05 mmol BTAB 45 87 mg 0 05 mmol O l g A Oo Ro N BTAB x 19 d EDMA MAA ADVN Ze4LELTETS ZC toluene Hv
130. acetonitrile methanol SPE SPE HPLC e SPE HPLC 2 72 SPE HPLC MIP I MS ppt acetonitrile 2 72 SPE H
131. PA 2 56 2 56 169 2 EDMA mhi 3 81 non ortho PCB PCB EDMA DVB PCB 3
132. toluene Tol EDS0 benzene benzene Ben ED50 VOC PIP Mic 2 12 VOC PIP toluene Tol ED50 Ben ED50 VOC ToI ED50 Ben ED50 Ben BDS0 Chl ED50 6 0 r ChI ED50 B Ben ED50 Chloroform vapor A Tol ED50 e 5 0 Lem on E 4 0 E z E ea m Benzene vapor ee eee OF Cee 4 ee i ax 0 4000 0 0 y ML d p o am o EX prs ug
133. 3 1 1 a X Milli Q Gradient A10 HPLC LC MS srade ethylene glycol dimethacrylate EDMA divinylbenzene DVB glycerol 1 3 dimethacrylate GDMA methacrylic acid MAA Osaka Japan b i 2 2 azobis 2 4 dimeth ylvaleronitrile ADVN 77 AXRIA X 1 3 BREMER V7 AYRXSO C 24 106 212 um
134. B 0806 13 BPA 0 1ng L SE 1 0ng L 4 PAHs 1 PAHs PAHs
135. Sil Cig FI FFVANVY YU AES VU DPNRED TZ A Silica Cja 7 2 2 Silica Cja 2 9 b 0806 31 2 2 HPLC Parameters SOlutes Mobile phase Hydrophobicity k pentylbenzene 80 methanol Hydrophobicity CH2 pentylbenzene butylbenzene 80 methanol Selectivity of co planner T O triphenylene o terphenyl 80 methanol Hydrogen bonding C P a caffeine phenol 30 methanol Ej PREPARA k a k t to to 2 2 t t k l k 2 3 RIOR
136. Pyri Cont P pyridine pyridine b 0806 54 Gas MIP 2 25 Tol Cont P toluene Pyri Cont P pyridine pyridine pyridine Pu Tol Cont P L B Tol NIP 1 A D A Tol MIP 1 2 0 O Pyri Cont P Q Pyri MIP 1 D A Pyri MIP 3 A S L5 e r A T A 6 Q 23 m e O e deese QI
137. 2 16 2 32 2 16 E SR E UAE o DVB o EDMA fon m DVB m EDMA pes p DVB p EDMA P Ruin 0 8 4 11 8 3 4 6 7 73 0 7 6 5 73 0 8 1 7 0 8 0 1 0 5 3 6 0 0 7 6 4 7 1 0 7 2 6 3 7 7 1 4 6 5 8 1 i7 6 9 8 5 1 6 3 6 3 7 0 0 7 7 1 8 4 1 3 4 5 3 4 7 0 7 6 9 8 4 1 6 B 0806 77 2 52 EDMA 2 p 2 17 2 53 2 17 ADR OMA MAE o DVB o EDMA A pvyg mEDMA A pyg EpMA PPRA 0 8 6 15 3 6 7 5 3 8 0 27 5 2 m 2 0 1 6 0 10 3 4 3 4 7 6 0 1 3 5 3 8 0 27 2 5 9 8 6 27 5 9 10 0 4 0 6 5 11 0 4 5 3 5 3 2 2 3 6 4 11 7 5 3 4 4 7 4 7 0 0 6 4 9 8 3 4 18 0 0o DVB 16 0 4 ll o EDMA 14 0 4 i 0 38 H 12 0 m DVB m EDMA TS m 60 4 ax oA wn p DVB 40 4 B
138. 1 25 methanol aq 2 3 25 methanol aq KE BPA c EVA 2 9 EDMA DVB MAA 4 vinylpyridine 4Vp toluene EDMA methanol SSA TBA 70 C 2 10 2 11 CNP7 99 24 7 9 um D 0806 50 2 9 EDMA _ EDMA EDMA MAA EDMA 75 wt MAA 25 wt EDMA 4Vp EDMA 75 wt 4Vp 25 wt DVB DVB 2 10
139. 3 300 mL P25 1 0 g 3 xx 4000 rpm 30 120 C 60 b 0806 48 P25 HE TB P25 HE d 1 7 mL 10 mg BETA or TBTA 1 0 mL 12 BETA or TBTA LC MS BTEA or TBTA LC MS HPLC Conditions Column YMC Pack ODS AM 75 x 4 6 mm 1 d Flow rate 0 2 mL min Mobile phase methanol 0 2 Formic acid 70 30 Temperature 40 C Injection volume 1 0 uL MS conditions Ionization ESI Polarity Positive Interface voltage 4 5 kV Interface temperature 200 C CDL voltage 50 V CDL temperature 250 C Heat block temperature 200 C Drying gas 0 1 Mpa Nebulizer gas N gt 1 5 L min
140. GDMA EDMA DVB e 500 log P 21 20 log Foes 2 21 log P 3 59 x E 400 s HIK i i e EDMA polymer 300 GDMA polymer A 1 0 2 0 3 0 4 0 5 0 Log Pow 2 21 BET log P 4 FA E TRE log Pow value chloroform benzene toluene chlorobenzene hexane 1 97 2 13 2 73 2 84 4 11 2 21 1og Pow PIP log Pow b 0806 52 1og Poy 2 21 log P 1og P EDMA 2 4 C log P
141. acetonitrile mV 125 100 15 50 00 50 200 250 30 min 1 13 acetonitrile 30 PAHs 1 3 acetonitrile HPLC b 0806 15 1 3 11
142. C MAA 4Vp 0 99 D b 0806 96 5 0 a EVA EVAEDMA 4Vp 1 b EVA EVAEDMA MAA 1 3 0 4 0 30 EVA EDMA 4Vp 5 2 0 QEVA EDMA MAA 5 x EVA EDMA 4Vp 20 x EVA EDMA MAA 20 EDMA 4Vp EDMA MAA 20 1 0 1 0 0 0 0 0 0 6 2 82 4Vp MAA HPLC conditions Column size 100 mm x 4 6 mm i d Mobile phase acetonitrile 0 1 formic acid aq 99 1 a acetonitrile b Flow rate 0 5 mL min Detection PDA Temperature 40 oC Solutes 100 ppm benzoic acid 5 uL a 100 ppm pyridine 5 uL b e
143. JAB CM021 101 8448 1 3 03 3219 5631 5616 5685 530 0012 1 1 4 14 06 6373 6541 6556 060 0807 2 8 1 9 011 700 6605 980 0021 2 9 27 12 022 221 6231 963 8877 6 7 2 024 939 3790 3050001 3 17 1 029 851 8511 8515 330 0843 1 41 8 048 646 0095 0081 220 0004 2 8 29 3 7 045 312 4421 311 4615 422 8062
144. 2 8 HPLC 8 Crosslinker Template Monomer 26 5 mmol 0 56 mmol 4 48 mmol NIP EDMA MAA sulpiride MIP EDMA MAA EDMA EDMA 5 25 g TBA 1 mmol BTAB 2 mmol SSA 2 20 i EDMA methanol ji methanol L i rich jv 105 VC EKSO ZEA vR F105 C 24 vi zevitt methanol vi HPLCH DT AICP CAR NaCl MIP I NIP I b 08
145. 24 24 20 uL HPLC 2 BPA 2 4 9G TEGVBE 3 4 3 30 BPA 0 BPA 0 7 MTE 43809 0 BPAU 2 38 020 715 2 4 BPA methanol 2 0 mL 30 min methanol 25 methanol aq 20 mL 1
146. 2009 12 6 GSC MAB GSC 2010 3 2011 2011 9 2012 4E RE E ZR Meme 2012 11 8 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 b 0806 119 H Tanaka Farumashia vol 46 7 664 668 2010 Modern Extraction Techniques D E Raynie Anal Chem 76 4659 4664 2004 Monosized stationary phases for chromatography T Ellingsen O Aune J Ugelstad S Hagen J Chromatogr 535 147 161 1990 Peer Reviewed Monolithic LC Columns N Tanaka H Kobayashi K Nakanishi H Minakuchi N Ishizuka Anal Chem 73 420 29 2001 Recent developments in the field of monolithic stationary phases for capillary electrochromatography F Svec J Sep Sci 28 729 745 2005 High Performance Polymer Based Monolithic Capillary Column K Hosoya N Hira K Yamamoto M Nishimura N Tanaka Anal Chem 78 5729 5735 2006 Controlled pore formation in organotrialkoxysilane derived hybrids from aerogels to hierarchically porous monoliths K Kanamori K Nakanishi
147. 28 MAR 2010411 b 0806 115 29 Spongy monolith MIR 2010 11 30 MAR 19 2010 12 31 MAR MEAK ETAL 19 2010 12 32 PCB MAB 18 2011 33 MAM 18
148. 8 PPCPs Oo Intensity 103 D e 0 0 a a S I UL 5 0 10 0 15 0 20 0 25 0 30 0 min 15 20 25 min Bl b 0806 106 6 7 1 lt gt 1 Selective Adsorption of Water soluble Ionic Compounds by Interval Immobilization Technique Based on Molecular Imprinting T Kubo Y Tominaga F Watanabe K Kaya K Hosoya Anal Sci 24 1633 1636 2008 2 High Throughput On line Preconcentration Using Spongy monolith Prepared by Pore Templates T Kubo F Watanabe K Kaya K Hosoya Chem Lett 37 950 951 2008 3 Effective Determination Method for a Cyanobacterial Neurotoxin 6 N methylamino L alanine T Kubo N Kato K Hosoya K Kaya Toxicon 51 1264 1268 2008 4 Poly Glycerin 1 3 Dimethacrylate Based Monolith with a Bicontinuous Structure Tailored as HPLC Column by Photoinitiated In Situ Radical Polymerization via Viscoelastic Phase Separation H Aoki N Tanaka T Kubo K Hosoya J Polym Sci Part A Polym Chem 46 4651 4673 2008 5 Well Controlled 3D Skeletal Epoxy Based Monoliths Obtained by Polymerization Induced Phase Separation N
149. FRAO log P 31 S b 0806 61 2 0 A SiLC18 6 EVA15 A NO OO r ED t C0 CN OK x 10 OM o CN C STM CO 11 TT d d i a a CO OO CO To T T m m ypy py N N CN N CN NAN o m S S D 550 FIZ PPE 8 0 oO 0 5 Deda c O 6 N c 2o N NSN Q D i gt Oo OQ OEDTE lt 5 ra 3 5 0 O AZ y 3 Aoc a o0 p o og o z 92 go 9 5 aaa 8 o 0 zoo e Y T 0 9 oS oO 2
150. v acetone 10 mL hexane 20 mL PCB hexane 2 0 mL KERI ur V TR UAR FID Flame Ionization Detector b 0806 41 fx YEH ig GC FID GC 2010 FID J amp W DB 5ms 0 32 mm ID x 30m EAH 1 0L HEAL 200 C 160 C 2 min 20 C min 320 C 20 min PCBO TR HA DUR E Se eA C PCB GCMS GCMS GCMS Agilent 5975C MSD J amp W DB 5ms 0 32mm ID x30m 1 0L
151. 899 MIP I 90 ppt g MB P25 MB UV MB MAT STXs STXs
152. TBTA P BTAB P BTBA meq g BLANK TBTA P BTAB P NN 2 65 1 8 1 6 1 4 1 2 1 0 0 8 0 6 0 4 0 2 0 0 e BLANK Retention factor amp BTBA TBTA BTAB 2 66 k HPLC conditions Flow rate 1 0 mL min Mobile phase methanol 0 4 M NaCl aq 70 30 v v Temperature 30 C Injection volume 5 0 uL Detection PDA BTBA benzyltributyl ammonium chloride b ue oak ee ei b 0806 85 MCPA 2 67 pH
153. methanol acetone 60 CC CoML Hake LL porogen imprinted polymer PIP PIP Chl ED50 chloroform RAL L CEDMA Hv 50 benzene Ben toluene Tol GDMA GD DVB DV i i Gas MIP b 0806 34 Cont P non imprinted polymer NIP Gas MIP Tol MIP 1 toluene MAA 10 vol MIP pyridine Pyri ACE ST c
154. BEVA15 EDMA EDMA EDMA 2 nm zy INT Be Os GAO Bim ee Oia Per mY TOS We eas bo AW
155. MCPA Miss Rx BC winters MCPA oe Biete D OR MOAR YEAS aA ETH TEER SNE Q oO fos lou Aniline 1 4 Bis 4 aminophenoxybenzene APB Metclopramide MCPA 67 b 0806 86 a Aniline Retention factor amp Retention factor amp 0 00 0 10 10 00 0 00 0 10 10 00 HC1 mM Retention factor amp 0 00 0 10 10 00 HCI1 mM 2 68 HPLC conditions Flow rate 1 0 mL min Mobile phase methanol HCl and 0 02 M NaCl 70 30 v v Temperature 40 C Injection volume 5 0 uL Detection PDA 10 pH Ath CM oO MO B3 UL c
156. SEM EDMA C DVB SEM F EVA DVB EVA EDMA EVA HX OU
157. imprinting factor IF 93 IF 1lysozyme PI gel PI gel PT gel 100 90 so le 70 Ht 60 E 50 3 40 e PI gel d 30 PI gel e 20 amp PI gel f gt 10 PIgel g 0 2 o amp o 9 9 P 2 92 PI gels 1ysozyme b 0806 102 RAC 93 PI gel 2 94 CORR PI gel 2 21 PI gel Cross linker porogen mL mL 14G PI gel c 0 109 14G PI gel d 0 100 14G PI gel e 0 091 14G PI gel f 0 083 I4G PI gel g 0 074 Porogen
158. 1 6 10 ng SIM d b 0806 10 1 1 300 pg 500 pg 3 RSD 1 1 Run BPA BPA d E2 E2 d 89 3 97 5 99 5 100 7 89 8 92 6 100 3 100 1 3 93 9 93 0 104 2 103 5 91 0 94 4 101 3 101 4 RSD 2 3 2 6 2 5 1 9 90 100 1 2 1 2 10 ng L m Run BPA E2 BPA E2 1 18 1 19 1 17 1 16 1 17 1 18 n 5 for each day 1 17 1 16 1 17 1 18 RSD 0 76 1 54 0 49 1 30
159. um 10 num 7 Kubo
160. 11 6 1 3 acetonitrile Dibenz a h anthracene 100 ng L 10 40 acetonitrile acetonitrile OTRE Fi AR AS HET ARIE B E 1 0 vie Naphtharene Dibenz a hlanthracene 30 ng L 1 2 1 2 60 ng L 3 6 10 14 300 ng L PAHs 5 0 10 30 1
161. 14G DMA SSA PEG gel DRAG Fill D RH EX 2 70 30 mol mol PAA E D DRA T TRE TEC Z7 v 5 EE AJTER 2 86 PEG gel 6 9 PEG gel 6 9 ZTLELEISIE O methanol J zc Ze z 7 Ex 0 PEG gel 2 87 methanol methanol PEG gel methanol PEG sel methanol PEG gedo
162. 0 2 mL min 2 0 mL min 50 mL MASK ENV 10 mm x 4 0 mm Shim pack VP ODS 150 mm x 2 0 mm i d 40 C 1 min 2 0 mL 4 min 8 0 mL APCI m z 227 233 271 274 2 0 250 ngL PPCPs 3 HERR Hae C b 0806 5 BPA 1 RF 20A Shimadzu Ex 230nm OCIA Em 310 nm 30 C 200 ng L BAP S0 mL 10 mg LE EVR 1 0 mL 10 ng L BPA
163. BaP BaP b 0806 65 596 MeCN 7096 MeCN 0 10 20 30 40 50 2 34 a l HPLC conditions Column size 100 mm x 4 6 mm 1 d Flow rate 2 0 mL min Mobile phase acetonitrile water 5 95 v v 0 25 min 70 30 25 40 min Temperature 40 C Detection UV 254 nm solutes benzo a pyrene 5 0 mL 100 ppm BaP Ux MDC 90 D BaP
164. gt gt 6 b 0806 18 7 1 Wo gt D A 17g DOTIEF 58 293 299 2009 2 Retention Properties of Macroporous Spongy Monolith and its Application for Concentration of Polyaromatic Hydrocarbons T Tanigawa K Kato Y Watabe T Kubo K Hosoya J Sep Sci 34 2193 2198 2011 3 Determination of Bisphenol A with Effective Pretreatment Medium Using Automated Column Switching HPLC with Fluorescence Detection T Tanigawa Y Watabe T Kubo K Hosoya J Sep Sci 34 2840 2846 2011 4 Trace Level Determination of Polycyclic Aromatic Hydrocarbons in River Water with Auto
165. 2013 6 b 0806 118 4 1 2 3 4 Nano Tech 2009 2009 2 Nano Tech 2010 2010 2 4 SSH 2011 2 2012 1 5 6 1 2 3 4 5 6 2009 MAR 2009 7 20 teat 2009 11 2009
166. 30 a BPAM A LRP EAR YU VIC BU SRIF 00 E489 38 00 E des 2 79 b 0806 94 3 5 gt 2 5 1 5 0 5 2 79 b SEM UE HAC 2 80 2 80 30 SEM c 2 81
167. ERAS AMA 71 2010 22 MRR 17 2010 6 PH 23 59 2010 9 24 Ax 21 2010 10 25 MRR 21 2010 10H 26 MA X 21 2010 10 27 RAT MAR 21 2010 10
168. 2 1 1 2 054 285 0124 25 a 604 8511 1 450 0001 1 47 1 19 052 565 7521 7531 604 8445 1 075 823 1604 1603 650 0033 93 9 078 331 9665 700 0826 3 10 6 086 221 2511 760 0017 1 6 1 9 087 823 6623 730 0036 4 25 15 082 248 4312 812 0039 4 20 4 092 283 3332 3334 a gis 0120 131691
169. P 8 8 B ir os J EX 0 0 0 5 10 15 20 25 x 2 24 4 Gas MIP pyridine toluene 100 S 90 Bun l ym 80 EX 70 S 60 A ul d E 40 E l l l l J 8 Q Q 8 Q D SEE Sd d ud ud S as gS 7 Bq 2 25 VOC pyridine 2 a 2 13 pentylbenzene C Ph U butylbenzene pentylbenzene go CH triphenylene o terphenyl e T O 2 13 0 22 EVA25 15 EVA15 k Cs Ph Silica Cja b 0806 55
170. 10 PEG MARR 2009 2009 7 11 MR 21 2009 9 ns 12 face RAAT WORSE A MRE 21 2009 9 13 HIRE MRE 58 2009 9 14 PEG BAL AA 58 2009 9 15 BAKKE MRE
171. S 2 57 GDMA SEM 2 58 GDMA SEM DMAEA Q MPC b HPLC HPLC acetonitrile 2 59 61 GDMA acetonitrile KIZ DMAEA Q MPC GDMA acetonitrile 90 100 MPC GDMA 6 benzene 29 toluene f benzoic acid be
172. e T O EVA2S HYD go T O EDMA EDMA 2 13 HPLC k Cs Ph a CH a T O a C P EVA25 7 14 1 41 3 08 0 01 EVA25 HYD 2 19 1 41 6 23 0 04 EVAI5 32l 1 42 3 36 0 03 PE 4 93 1 43 2 27 0 74 EDMA 3 29 1 24 2 10 0 18 GDMA 0 19 1 13 3 03 0 44 Su C18 7 50 1 40 1 48 0 43 2 26 EVA25 EVA1S EVA2S EVA2S HYD EVA25 HYD
173. DB non ortho PCB TBI OF PCB DB PCB 2 b 0806 80 1 a SEM 2 57 2 58 6 3 um
174. 1 5 So b 0806 29 2570 Hc XERUCBEBCERwIM 7
175. 1 1 Xo Ope Tr ed 10 mM acetonitrile 6373S v v acetonitrile670 0 8 mL min 2 0 mL min 50 mL MASK ENV 30 mm x 4 0 mm i d Shim pack VP ODS 150 mm x 4 6 mm i d 40 C 1 min 2 0 mL 4 min 8 0 mL 2 A 17 E2 water methanol 40 60 5 95 v v 30
176. 2 44_GDMA PBC EDMA CMS EDMA Bd 2 45 EDMA EDMA PCB EDMA PCB E FER dy XL Q 5 10 15 20 25 30 2 45 EDMA PBC DVB PMB PMB 46 tetrahydrofuran acetonitrile PMB DVD PMB PCB Mk C ANS ee menm U 10 15 20 25 30 39 2 46 _DVB PMB PBC o m p 3
177. 0 22 um OD 2 72 MS 73 REREAD 87 6 ng L 800 87 6ng L Sulpiride O O O Intensity 10 I O O 200 20 2 73 SPE HPLC 2 72 b 0806 90 4
178. 6 mee LTRK FR EH BR RIL ng LO RE BPA RODA e KEAR ARES ASTM S N 3 Eqs ox TE 1 0 5 0 10 100 1000 ng L 3 5 0 ng L BPA TH PLA YI UT heme DT RIT OTe 4 PAHs 1 2 EPA 16 acenaphthylene 13 1 naphthalene acenaphthylene acenaphthene fluorene phenanthrene 7 5 6 TD Q gt anthracene Ss Q O4 fluoranthene chrysene pyrene 10 teen 12 13 FOX 00 benzo b fluoranthene Sad 2 benzo k fluoranthene 14 benzolalpyrene dibenz a h anthracene e ease benzo g h i perylene benzolalanthracene indeno 1 2 3 cd pyrene 1 2 EPA PAHs PAHs 30
179. Mic PCB 2 3 b 0806 73 81 4 3 4 5 126 3 4 3 4 5 4169 3 4 5 3 4 5 E 77 3 4 3 4 3 PCB 2 3 4 PCB 77 169 2 benzene CW SARE COV CH h 47 DVB xylene non ortho PCB A fa ima LA 5 10 15 20 2 47 DVB xylene non ortho PBC
180. a Fe Wes b 15 mLO polypropylene tube 119 x 14 7 mm i d CEHA SHAKE CART H PEBBTECE 7c 001 0 wt 30 polypropylene tube 50 C 24 60 C 2 PEG gel Bi L methanol PEG gel equilibrium swelling ratio 2 5 W PEG gel W PBG gel g g W Wa Wa eee b 0806 51 c PEG gel 36 C PEG gel 36 C 40 mg 10 mL HR relative swelling ratio 2 6 V
181. p EDMA 2 0 4 SS p 0 0 2 53 b 0806 78 PCB 81 2 34 2 54 81 p 2 EDMA m 2 DB p m 77 EQ 55 DV Xy 30 WH ED Xy 2096 DV Xy S ED Xy S 2 55 77 mm 1 om p DB b 0806 79 non ortho PCB 169
182. 20 545 FF 24 2 409 20 Be EVA polychlorinated biphenyl PCB DMSO DMSO PPCPs
183. 5 A R 3 xN 3 E o o us e o e m e D NO ke 5 15 10 NII I MIP I ZN LC Conditions mobile phase 50 mM formate buffer pH 3 0 Acetonitrile 2 8 column size 100 mm x 4 6 mm i d flow rate 0 5 mL min detection UV 254 nm temperature 40 C injection 5 uL solutes 1 acetone 1000 ppm 2 aniline 100 ppm 3 hexylbenzene 100 ppm 2 71 MIP II NIP I a b d 4 100 mg SPE 100 ppm HPLC sulpiride MIP NIP NIP I 3 0 mL MIP I 30 mL MIP I
184. acetonitrile EVA1S HYD SCC 61 9 b 0806 38 2 10 succinyl chloride Oo O O O C43 O ko gt A B HCI 2 11 10 mL dimethylformamide 20 acrylyl chloride AC 12 4 mL RALE R1 10 mL dimethylformamide 20 pyridine12 3 mL 2 1 60 C 48 50 acetonirtile aqg 20 min 6 acetonitrile EVA25 HYD AC acrylyl chloride 30 mL 48
185. S Na 1 2 thiophenol 10 3 3 2 15 3 methanol aq H20 3 0 mol L CRL 16 4 b 0806 40 S Na S 3 0 eq H20 30 MeOH aq RT MeOHag RT S S sf en l l n 2 15 3 2 16 4 ti 2 4 CLICK UT potassium iodide 1 thiophenol 1 potassium hydroxide 2 2 4 ee potassium potassium 3 hydroxide eq iodide ml g ml mmol mmol mmol DV B base4 4 0 0 914 6 0 12 0 12 0 6 0 EDMA 4 0 1 05 6 0 12 0 12 0 6 0 GDMA 4 0 1 12 6 0 12 0 12 0 6 0 DVB PMB 4 0 0 914 6 0 12 0 12 0 6 0 iv 52 mm x 9 0 mm D 2 17 0 75g 2 17
186. acetonitrile 20min 6 EVA25 HYD AC DEA 12 OH 16 0 O owe PW QU CC O N CH NH gt a 12 3 PCB PCB lt ADVN xylene 3 pentamethylbenzene PMB dichlorobenzene 1 3 DB trichlorobenzene 1 3 5 TB DVB GDMA EDMA chloromethyl styrene CMS phenyl vinyl sulfoxide PVS dimethyl sulfoxide DMSO sodium iodide Nal thiophenol potassium hydroxide KOH hydrogen peroxide H202 PCBEE YE dh T PCB Cleanup Spike Syringe Spike Sampling Spike Ge Ci Labeled mixture nonane solution a IV b 0806 39 3 2
187. B 0806 121 Fully automated liquid chromatography mass spectrometry determination of 17 beta estradiol in river water Y Watabe T Kubo T Nishikawa T Fujita K Kaya K Hosoya J Chromatogr A 1120 252 259 2006 Trace level determination of polycyclic aromatic hydrocarbons in river water with automated pretreatment HPLC Y Watabe T Kubo T Tanigawa Y Hayakawa K Otsuka K Hosoya J Sep Sci 36 1128 1134 2013 Sulpiride and headache syndromes D De Maio L Valzelli G Scieghi Psychopathology 12 202 208 2010 Development and validation of stability indicating HPLC and HPTLC methods for determination of sulpiride and mebeverine hydrochloride in combination I A Naguib M Abdelkawy European journal of medicinal chemistry 45 3719 3725 2010 Differential response of A 68930 and sulpiride in stress induced gastric ulcers in rats N Rasheed A Ahmad N Singh P Singh V Mishra N Banu M Lohani S Sharma G Palit Eur J Pharmacol 643 121 128 2010 Determination of sulpiride in pharmaceutical preparations and biological fluids using a Cr III enhanced chemiluminescence method M N Khan M R Jan J Shah S H Lee Y H Kim Luminescence 2012 Detection occurrence and fate of 22 psychiatric pharmaceuticals in psychiatric hospital and municipal wastewater treatment plants in Beijing China S Yuan X Jiang X Xia H Zhang S Zheng Chemosphere 90 2520 2525 2012 Chromatographic Characteriz
188. 0 00 0 01 0 10 1 00 10 00 HC1 mM 2 69 pH pK b 0806 81 c HPLC 2 70 a c sulpiride MIP NIP HPLC 2 19 pg pH 19 a b acetonitrile sulpiride MIP MIP Retention factor k Bl sulpiri
189. 2 0 i i e 2 0 1 0 2 0 3 0 4 0 5 0 6 0 7 0 1 0 2 0 3 0 4 0 5 0 6 0 7 0 Log P Log P 2 27 log Pvslogk outlined plot plots for Planar PAHs filled plot plots for sterically bulky PAHs HPLC conditions Column size 100 mm x 4 6 mm 1 d Flow rate 1 0 mL min Mobile phase acetonitrile water 70 30 v v Temperature 40 C Detection UV 254 nm c 2 28 4 o m p gt b 0806 58 m p
190. 300 C ARTE 70 C 1 5 min gt 30 C min 185 C 6 0 C min 300 C m z 35 37 250 C F NICI negative ion chemical ionization 99 999 2 3 X 2 5 IV ADVN xylene or 1 3 DB or 1 3 5 TB DVB or EDMA CMS or PVS 60 C 24 BALL acetone 65 C EL methanol acetone 70 C 106 212 mm b 0806 42 KR Q 5 monomer DV Xy DVB CMS xylene Xy DV DB DVB CMS 1 3 dichlorobenzene DB DV TB DVB CMS 1 3
191. Advancement of reactivity between bioactive compounds immobilized on the novel solid phases and target proteins Tomoko Mori Takuya Kubo Ken Hosoya 10th Tetrahedron Symposium in Organic and Bioorganic Chemistry Paris France June 2009 Poster Spontaneous water cleanup phenomenon of polymer based monoliths having co continuous structure Ken Hosoya Takuya Kubo Yuichi Tominaga Tomohisa Saito Yuzuru Kakudo Tomoko Mori 10th Tetrahedron Symposium in Organic and Bioorganic Chemistry Paris France June 2009 Poster Development of PEG type monolithic polymer semi micro columns for HPLC Tomoko Mori Takuya Kubo Ken Hosoya The Ist FAPS Polymer Congress Nagoya Japan October 2009 Poster 10 Selective adsorption and degradation of toxic compounds by organic inorganic hybrid material Takuya Kubo Yuichi Tominaga Ken Hosoya The Second French Research Organizations Tohoku University Joint Workshop on Frontier Materials Sendai Japan December 2009 Invited Speaker 11 New monolithic chromatographic materials based on organic polymers K Hosoya FRONTIER 2010 Albi France December 2010 Invited Speaker 12 Effect of a quasi biomembrane on affinity resin for capturing proteins T Mori T Kubo K Hosoya 2010 International chemical congress of pacific basin societies Hawaii USA December 2010 Poster b 0806 111 13 Development of molecularly imprinted polymers enabling selective adsorption for gaseous compoun
192. GDMA 90 100 e HPLC 1 RIX 2 dcSTX dgcSTX dcSTX f
193. Monitoring SIM BTEA 192 15 m z TBTA 237 75 m z e MB UV 365 nm L LC MS MB TBTA A dcSTX MB or dcSTX LC MS HPLC Conditions MB Column Zic HILIC 150 mm x 2 0 mm 1 d Flow rate 0 2 mL min Mobile phase acetonitrile 0 05 Formic acid 50 50 Temperature 40 C Injection volume 1 0 uL MS conditions MB Ionization ESI Polarity Positive Interface voltage 4 5 kV Interface temperature 200 C CDL voltage 50 V CDL temperature 250 C Heat block temperature 200 C Drying gas 0 1 Mpa Nebulizer gas N gt 1 5 L min Monitoring Full scan 0 300 m z HPLC conditions dcSTX Column TSK gel Amide 80 150 mm x 2 0 mm 1 d Flow rate 0 2 mL min Mobile phase A 3 6 mM Formic acid 2 0 mM Ammonium formate pH3 5 Mobile phase B A acetonitrile 5 95 B 80 55 linear gradient 0 min to 20 min Temperature 40 C Injection vol
194. acetonitrile MASK BENV 1 3 water acetonitrile 60 40 v v 14 acetonitrile 60 22 acetonitrile 100 36 acetonitrile 100 1 5 mL min 1 0 mL min 4 0 mL min 10 mL MASK EMV 30 mmL x 4 0 mm i d Restek Pinacle II PAH 250 mmL x 4 6 mm i d 40 C 2 min 2 0 mL 2 min 2 0 mL 6 270 330 nm Visa 250 370 nm 19 5 330 430 nm 21 53 270 390 nm 23 290 430 nm 25325 370 460 nm 28 270 330 nm b 0806 6 B 0806 7 1 AU EO 2 8 3 9 4 10 5
195. 100 ppm DMA 5 0 uL EVA EDMA SSA 20 AEVA EDMA 209 6 EVA B 0806 97 6 a PEG gel SSA PBG DMA methanol T PEBG DMA SSA 3 0 mmol 14 mL PEG gel PEG gel PBEBG gel 0 PBG sel 2 84 4G DMA PEG gel 4G DMA
196. 15 Hz Tsnleeln urls usi 34 m Peak Top ml DVB EDMA ZAIN 1e ololololololo lilolol GEN e lololol ool tolor og 6 4 8 6 4 2 ps 1 of cof 0O ol co o ct of oo 6 6 8 10 8 6 5 e ilololololilolololile 6 8 i0 8 6 L 3 al ool Tofo TtT Tr 1 9 6 6 6 8 6 L 4 Je x qo p x qo pd peg pj 91 6 6 8 10 6 6 4 po 1 of of ct Tl of of il il of co 6 6 8 10 8 6 s p ilololilolilolililole 6 6 8 8 6 Ca w 1olo lilolololilililiole 8 6 I5 8 8 C5 m o ilolilolililolilols 6 8 s 10 6 15 8 QV OO OO o A o o QN QN OO OO QOO QV OV ON OX 00 ND ON O00 Qc 0o qnc OO A A Oo F amp F oof BADAAHDAAADAARAATDADAARDHRWOAARAAAAAARRA e QV OON O0 Q RO DD 00 QOO O00 QOO ON MAO RO cO oO oo DD DD A 0 0000000000 Oo DD DD A OO OD oo ON OD oo 00 00 o QV OOo o QV ON OOo CV Ov OO CO QN o0 OO OO OO ON 6 8 6 6 8 6 6 8 8 8 6 8 6 8 6 6 6 6 HERO EMME Do p m D EZ 05 EDMA
197. 37 000 He m zio ux 2 sm 2mmidxiomt mazo Lxs2 c Sum 2mmidxsommt D nean TaJ TFA URL http www chemcoplus cojp e mail Info chemcoplus coJp ARSH 7577 0065 3 10 7 TEL 06 6787 5551 FAX 06 6787 6688 108 0074 2 19 17 701 TEL 03 3444 4201 FAX 03 3444 4238 PDA SES IUIS CBM 20A 228 45012 41 NEN LC 20AD 228 45000 41 LC 20AT 228 45001 41 SIL 20ACHT 228 43001 95 CTO 20AC 228 45010 31 PDA SPD M20A 228 45005 31 FCV 12AH 228 45013 91 FCV 13AL 228 45016 91 DGU 20As 228 45019 41 VP 228 35308 91 S5U05316L 228 45093 93 PC LCsolution Multi PDA B _ 5UM 228 45019 41 223 61313 91 228 41748 91 2UM MS TP Assist
198. 5 gt NN O 9o o Oc 2 31 silica Cja solute 1 toluene 2 salicylic acid 3 methyl benzoate 4 anisole 5 benzene 6 methyl 4 hydroxybenzoate 7 benzoic acid 8 nitrobenzene 9 benzaldehyde 10 acetophenone 11 phenol 12 salicylamide 13 acetyl salicylic acid 14 benzyl amine 15 benzamide 16 caffeine HPLC conditions Column size 100 mm x 4 6 mm 1 d Flow rate 1 0 mL min Mobile phase methanol water formic acid 40 60 0 1 v v v Temperature 40 C Detection UV 254 nm 2 32 silica Cj EVA1S EDMA GDMA 2 31 2 31 2 32 AE b 0806 62
199. 5 5 0 l 0 0 30 60 90 120 150 180 210 0 100 200 300 400 2 75 MB UV 2 76 _MB UV irradiation non UV irradiation MB MBD H fk MB MB LC MS 2 77 76 P25 SC AL MS 0 MB azure A UV 60 MB azure AD azure B UV 120
200. 53 PCB MARS 23 2012 11 54 MAB 23 2012 11 H JH 55 PEG mIKME MAB 23 2012 11 Aso MAB 23 2012 EITA 56 Ne 57 teeth MAR 73 2013 CF 58 2 SPE LC MS MAR KA 20
201. 58 2009 9 16 TURE RRA MRE 20 2009 11 OR Ne 17 MAB 20 2009 11 A 1 HI b 0806 114 18 PEG MAR 20 2009 11H Afin WBA HWS MRE 20 2009 11 19 Ne 20 MAR 10 GSC 2010 3 21
202. 9 4 E Mr MM E 2009 3 5 FOSS MRS 70 2009 A 6 Afin Poo MAR 16 2009 5 T YES ARAA BHRR 16 2009475 H B 0806 113 8 AeA VOSS Peace MKS 2009 2009 7 9 2009 2009 7
203. HPLC conditions Column TSK gel Amide 80 150 mm x 2 0 mm 1 d Flow rate 0 2 mL min Mobile phase A 3 6 mM Formic acid 2 0 mM Ammonium formate pH3 5 Mobile phase B A acetonitrile 5 95 B 80 55 linear gradient 0 min to 20 min Temperature 40 C Injection volume 10 uL MS conditions Ionization ESI Polarity Positive Interface voltage 4 5 kV Interface temperature 200 C CDL voltage 50 V CDL temperature 250 C Heat block temperature 200 C Drying gas 0 1 Mpa Nebulizer gas N gt 1 5 L min Monitoring SIM 257 m z 3 s As HALF OS he BDMA toluene 2 0 wt 50 C 24 methanol tetrahydrofuran BASE 5 0 um b EDMA 2 0 gs methanol 100 mL
204. Poster 10 Trace Level determination of polycyclic aromatic hydrocarbons in river water with automated pretreatment HPLC Y Watabe Y Hayakawa T Kubo T Tanigawa K Hosoya SETAC Asia Pacific 2012 Kumamoto Japan September 2012 Poster B 0806 20 gt 1 LC MS HEAD Mae MARR 15 2008 5 2 LCMS MAR REA 450439 Tf 2009 2009 7 3 CN M nn Be XE 2 73 Tr un MARR 58 2009 9 4 LCMS DARHA AM MERRE MARR
205. Tsujioka N Ishizuka N Tanaka T Kubo K Hosoya J Polym Sci Part A Polym Chem 46 3272 3281 2008 6 Properties of Flaky Affinity Resin with Co continuous Structure T Mori A Tanaka T Kubo K Kaya M Sakamoto K Hosoya Bioorg Med Chem 16 1983 1991 2008 7 Development and Applications of Fragment Imprinting Technique T Kubo Chromatography 29 9 17 2008 8 New Values of Molecular Extinction Coefficient and Specific Rotation for Cyanobacterial Toxin Cylindrospermopsin T Sano S Kikuchi T Kubo H Takagi K Hosoya K Kaya Toxicon 51 717 719 2008 9 10 11 12 13 14 15 16 17 18 b 0806 107 A Novel Chip Device Based on Wired Capillary Packed with High Performance Polymerbased Monolith for HPLC Reproducibility in Preparation Processes to Obtain Long Columns K Hosoya M Sakamoto K Akai T Mori T Kubo K Kaya K Okada N Tsujioka N Tanaka Anal Sci 24 149 154 2008 Polymer Based Monolithic Columns in Capillary Format Tailored by Using Controlled in situ Polymerization H Aoki N Tanaka T Kubo K Hosoya J Sep Sci 32 341 358 2009 Importance of Surface Properties of Affinity Resin for Capturing a Target Protein Cyclooxygenase 1 T Mori T Kubo K Kaya K Hosoya Bioorg Med Chem 17 1587 1599 2009 Quantitative evaluations of surface concentrated amino groups on monolithic type solid supports prepared by copolymerizatio
206. a 10 6 10 2 50 EDMA non ortho PBC b 2 SLRS 2 12 SEM 2 1 b 0806 75 pox was 3 4 x E a LL pon a 4 S34gmrT5 0kV x100 ESED BRR ar ame ss 000m RS5400 15 0kv xi QED 80Pa DV Xy DV DB DV TB EX up x ED Xy ED DB ED TB S 1 247 RS a 1 T J z N x x a gt e b gt p e i we x Be o o L f vost y 3 1 Eb dq OO EpieoPa gt A S8400 15 0kV x100 ESED 80Pa E WE sogum 3400 18 0KVX1UQESED 80Pa DV Xy S DV DB S DV TB S 2 1 SEM 12 15
207. ko 2 A B diphenyl T CO L L4 p terphenyl anthracene naphthalene tripghenylmethane 5 benzo a pyrene naphthacene triptycene rs 30 eee alise OD chrycene pyrene phenanthrene fluorene m terphenyl C cd C 2 diphenylmethane o terphenyl E Q eS J benz a anthracene c benzo e pyrene ui triphenylene 2 9 18 e 2 10 mL acetonitrile EVA HYD 20 succinyl chloride 3 870 mL 1 10 mL acetonitrile 20 triethylamine 9 466 mL 2 SRR lacoK m PF CHR LE 24 2 10 50 acetonirtile aqa 20min 6 2 11
208. 15 20 25 2 84 PEG DMA 14G DMA 23G DMA 2 8 PEG gel PEG gel PBG DMA PEG gel 14G DMA b 0806 98 80 70 60 50 40 30 20 10 0 20 30 40 50 60 70 80 14G based hydrogel 5 ok 38 g g FBR 23G based hydrogel 2 85 b
209. 5 trichlorobenzene TB ED Xy EDMA CMS xylene Xy ED DB EDMA CMS 1 3 dichlorobenzene DB ED TB EDMA CMS 1 3 5 trichlorobenzene TB DV Xy S DVB PVS xylene Xy DV DB S DVB PVS 1 3 dichlorobenzene DB DV TB S DVB PVS 1 3 5 trichlorobenzene TB ED Xy S EDMA PVS xylene Xy ED DB S EDMA PVS 1 3 dichlorobenzene DB ED TB S EDMA PVS 1 3 5 trichlorobenzene TB Xie 6 2 6 DV Xy DV DB DV TB ED Xy ED DB ED TB DV Xy S DV DB S DV TB S ED Xy S ED DB S ED TB S Xylene 10 0 mL 81 1 mmol 10 0 mL 81 1 mmol 10 0 mL 81 1 mmol 10 0 mL 81 1 mmol 1 3 DB 8 0 mL 68 1 mmol 8 0 mL 68 1 mmol 8 0 mL 68 1 mmol 8 0 mL 68 1 mmol 1 3 5 TB 7 0 mL 52 3 mmol 7 0 mL 52 3 mmol 7 0 mL 52 3 mmol 7 0 mL 52 3 mmol monomer DVB 8 0 mL 56 2 mmol 8 0 mL 56 2 mmol 8 0 mL 56 2 mmol 8 0 mL 56 2 mmol 8 0 mL 56 2 mmol 8 0 mL 56 2 mmol monomer EDMA 8 0 mL 42 4 mmol 8 0 mL 42 4 mmol 8 0 mL 42 4 mmol 8 0 mL 42 4 mmol 8 0 mL 42 4 mmol 8 0 mL 42 4 mmol CMS 2 0 mL 14 1 mmol 2 0 mL 14 1 mmol 2 0 mL 14 1 mmol 1 6 mL 11 2 mmol 1 6 mL 11 2 mmol 1 6 mL 11 2 mmol PVS 1 9 mL 14 7 mmol 1 9 mL 14 7 mmol 1 9 mL 14 7 mmol 1 4 mL 10 5 mmol 1 4 mL 10 5 mmol 1 4 mL 10 5 mmo
210. A ATBTA A 0 2 NaCl 0 1 0 0 002 0 004 0 006 0 008 0 01 M 1 0 b 0 9 R e 0 8 1 e 0 7 A e rum LJ g 0 6 m FO 0 5 BS E mi O BDS 0 4 ABTEA E 0 3 A BTBA TBTA a 0 2 NaCl 0 1 l 0 0 002 0 004 0 006 0 008 0 01 M 89 a SSA hydrogel b VBTMAC hydrogel pH EDA 2 90 EDA pH pH EDA HCl EDA pH 2 91 PEG gel HCl1 BEDA EDA PEG gel HCI HCI 1 0 mL
211. IIP 2 64 IIP TBA P dcSTX TBTA P BTAB P dcSTX STX TBTA_ P 100 80 60 dcSTX TBA P D TBTA P D BTAB P D 2 64 IIP dcSTX b 0806 84 3 a HPLC MCPA 2 65 100 66
212. Uv 3ESN NIC 0 BABA SACRE 6 fd f ABS TENUN JEU I A 5 hu I MUKIEBBDIEIL7 AFORRAR E ae 7 Pr N FRAO 1 SEA 7a E RTT MASK REE L CES SE EES 9 2 4 6 5 W V M 16 B M Wer poo i x10 000 3 m X9 X T ta Da 0 5 T3 0 5 10 15 20 25 min L d i5 Column VP 20mmlID Cum are CHEMCO M MASICENYO Mobile phase water acetonitrile Gradient Elution ACA T 200 mi ary 7 4 rom v amd ser 0 2 mL min Temp 40 C Detection MS 227 mz SIM 10L 24 9 222 A2 r17 Jb AOBUMSET hi H3 eB 2 OHEMCOO MASK ENV no
213. acetonitrile 0 4 M NaCl aq 70 30 Temperature 30 C Injection volume 5 0 uL Detection PDA c HPLC TBTA P 1 2 HE 1 2 300 ppm BTBA 2 63 BTBA 1 BTBA TBTA P TBTA P 58 9 BTBA B 0806 83 TBTA P
214. from Oligo Ethylene oxide Divinyl Ether by a Cationic Polymerization T Mori T Kubo K Hosoya Colloid Polym Sci 288 1651 1653 2010 Polymers of 2 methacryloyloxyethyl phosphorylcholine truly work as cell membrane mimic T Mori T Kubo K Hosoya Colloids Surf B 84 181 186 2011 Surface Modification of T1O2 for Selective Photodegradation of Toxic Compounds Y Tominaga T Kubo K Hosoya Catal Commun 12 785 789 2011 Comprehensive Study of Proteins that Interact with Microcystin LR T Mori T Kubo K Kaya K Hosoya Anal Bioanal Chem 402 1137 1147 2011 Problems and Improvements of the Regulated Analyses Method on GC for Nonyl Phenol Isomers A Kobayashi Y Kitahara K Toyota S Suzuki T Kubo K Hosoya Anal Methods 4 569 872 2012 Synthesis of Novel Polymer Type Sulfoxide Solid Phase Combined with the Porogen Imprinting for Enabling Selective Separation of Polychlorinated Biphenyls Y Tominaga T Kubo A Kobayashi K Yasuda K Kato K Hosoya Chemosphere 89 378 382 2012 Development of Molecularly Imprinted Porous Polymers for Selective Adsorption of Gaseous Compounds Y Tominaga T Kubo K Yasuda K Kato K Hosoya Micro Meso Mater 156 161 165 2012 ZMPPR EZ 61 371 381 2012 Specific Chromatographic Retentions on Polymer Pore Surface of
215. m LOU p A 2770 00 Toluene vapor 00 x amp 9 0 120 g 2 22 VOC B 0806 53 2 12 VOC PIP Vapors chloroform benzene toluene Chl ED50 Ben ED50 1 14 1 09 1 26 ToI ED50 1 25 1 22 0 89 Ben ED50 ChI ED50 0 88 0 92 0 79 ToI ED50 1 10 1 13 0 71 Tol EDS0 ChI ED50 0 80 0 82 1 12 Ben ED50 0 91 0 89 1 42 PIP chloroform benzene toluene 2 23 PIP VOC PIP 1 0 VOC chloroform Chl_ EDS0 benzene toluene ChI EDSO VOC PIP VOC
216. 00 200 ng L 1 2 1 2 2 3 6 10 14 10 PAHs 30 ng L 1 2001 2 60 ng L 3 6 10 1414300 ng L 272 5 Kk 5 PAHSEE T th Ze ifs b 0806 8 6 10 ns L PAHs LOD LOQ PAHs 3 3 LOD 10 LOQ 5 4 1 VAT ABE 180
217. 06 41 TL SOsNa p styrenesulfonic acid sodium salt SSA sulpiride N toN 11 108 A CI C H NK 2 4 ONC H CI NCC H CI 4H 3 4Hg 3 tetrabutylammonium chloride 4 4 bis tributylammonium methyl chloride TBA biphenyl BTAB N toN 12 020 A 2 20 e HPLC acetonitrile pH SPE SPB HPLC 4 a AEROXIDE TiO P25 P25 55 9 m2 g 15 nm Tokyo Japan b VTMS
218. 08 3 A 17 MAS DHr I 58 293 299 2009 4 Effective Recognition on the Surface of a Polymer Prepared by Molecular Imprinting Using lonic Complex Y Tominaga T Kubo K Kaya K Hosoya Macromolecules 42 2911 2915 2009 5 Novel Separation Medium Spongy Monolith for High Throughput Analyses F Watanabe T Kubo K Kaya K Hosoya J Chromatogr A 1216 7402 7408 2009 6 Surface Modification of Ti02 for Selective Photodegradation of Toxic Compounds Y Tominaga T Kubo K Hosoya Cata Commun 12 185 189 2011 1 Retention Properties of Macroporous Spongy Monolith and its Application for Concentration of Polyaromatic Hydrocarbons T Tanigawa K Kato Y Watabe T Kubo K Hosoya J Sep Sci 34 2193 2198 2011 b 0806 vii 8 Determination of Bisphenol A with Effective Pretreatment Medium Using Automated Column Switching HPLC with Fluorescence Detection T Tanigawa Y Watabe T Kubo K Hosoya J Sep Sci 34 2840 2846 2011 9 Synthesis of Novel Polymer Type Sulfoxide Solid Phase Combined with the Porogen Imprinting for Enabling Selective Separation of Polychlorinated Biphen
219. 1 0 mL IIP 10 ms 12 xu BE TBTA LC MS LC MS EF TBTA b 0806 45 HPLC conditions Column Inertsil ODS 3 150 mm x 2 1 mm 1 d Flow rate 0 2 mL min Mobile phase acetonitrile O 1 Formic acid aqueous 90 10 Temperature 40 C Injection volume 1 0 uL MS conditions Ionization ESI Polarity Positive Interface voltage 4 5 kV Interface temperature 200 C CDL voltage 50 V CDL temperature 250 C Heat block temperature 200 C Drying gas 0 1 Mpa Nebulizer gas N gt 1 5 L min Monitoring SIM 237 75 m z h dcSTX 0 50 mL 1 75 mL acetonitrile 5 25 mL dcSTX 70 acetonirtile aq dcSTX 1 5 mL IIP 10 mg 24 dcSTX LC MS LC MS dcSTX
220. 10 EtOH aq Initiator ADVN 1 0 wt SSA lysozyme 6 0 mol mol SSA lysozyme porogen 0 006 g mL polymerization UV 365 nm 3 h 100 4 mNIP gel 90 PI gel 80 70 60 50 40 30 20 10 NN Hydrogel d Hydrogel e Hydrogel f Hydrogel g 2 93 Lysozyme IE dIN dIN 5 amp 4 CA s 0 9 dn 9 NIP gel PI gel Hydrogel d Hydrogel e Hydrogel f Hydrogel g 2 94 Lysozyme b 0806 103 5 1 HIT
221. 11 2009 3 3 MRS 70 2009 5 4 SKM AI 21 2009 9 9 SKK SAX 58 2009 9 6 MRS 20 2009 11 1 BUSS MRS 20 2009 11 8 Mem 17 2010 6 9
222. 2 methacryloyloxyethyl phosphorylcholine MPC monomer c HPLC GDMA 2 GDMA DMAEA Q MPC SEM 100 mm x 4 6 mm i d UL HPLC 18 0 O O pe o 9 l P E YOON ate Cl 0 Po OH O GDMA DMAEA Q MPC monomer 2 18 GDMA 2 a tibutylamine Osaka Japan b a a dichloro p xylene or 4 4 bis chloromethyl biphenyl tributylamine acetonitrile b 0806 44 100 C 24 VOR 2c d acetonitrile
223. 2001 Determination of estrone and 17B estradiol in human hair by gas chromatography mass spectrometry M H Choi K R Kim B C Chung Analyst 125 711 714 2000 Analysis of steroids in environmental water samples using solid phase extraction and ion trap gas chromatography mass spectrometry and gas chromatography tandem mass spectrometry C Kelly J Chromatogr A 872 309 314 2000 Sensitive method for the determination of bisphenol A in serum using two systems of high performance liquid chromatography J Sajiki K Takahashi J Yonekubo J Chromatogr B 736 255 261 1999 Determination of bisphenol A in blood using high performance liquid chromatography electrochemical detection with solid phase extraction J Sajiki J Chromatogr B 775 9 15 2001 Improved Detectability with a Polymer based Trapping Device in Rapid HPLC Analysis for Ultra low Levels of Bisphenol A BPA in Environmental Samples Y Watabe T Kondo H Imai M Morita N Tanaka J Haginaka K Hosoya Anal Sci 20 133 137 2004 Fully automated liquid chromatography mass spectrometry determination of 17beta estradiol in river water Y Watabe T Kubo T Nishikawa T Fujita K Kaya K Hosoya J Chromatogr A 1120 252 259 2006 Monodisperse polymer beads as packing material for high performance liquid chromatography Synthesis and properties of monidisperse polystyrene and poly methacrylate latex seeds V Smigol F Svec K Hosoya Q Wang J
224. 7p concentration in tissue of the scleractinian coral Montipora verrucosa A M Tarrant S Atkinson M J Atkinson Comp Biochem Physiol A 122 85 92 1999 Biological measurement of estrogenic activity in urine and bile conjugates with the in vitro ER CALUX reporter gene assay J Legler A Jonas A Brouwer A J Murk Environ Toxicol Chem 21 473 479 2002 The fate and behaviour of human estrogens in a night soil treatment process H Takigami N Taniguchi T Matsuda M Yamada Y Shimizu S Matsui Water Sci Technol 42 45 51 2000 8 9 10 11 12 13 14 15 16 17 18 19 B 0806 22 Determination of Endocrine Disrupting Phenolic Compounds and Estrogens in Surface and Drinking Water by HRGC NCI MS in the Picogram per Liter Range H Kuch K Ballschmiter Environ Sci Technol 35 3201 3206 2001 Quantitative analysis of estrogens in human urine using gas chromatography negative chemical 1onisation mass spectrometry X Xiao D McCally Rapid Commun Mass Spectrom 14 1991 2001 2000 Trace analysis of estrogenic chemicals in sewage effluent using liquid chromatography combined with tandem mass spectrometry A Lagana A Bacoloni G Fago A Marino Rapid Commun Mass Spectrom 14 401 407 2000 Assessment of estradiol and its metabolites in meat D Manue Y Deceuninck K Pouponneau A Paris B Le Bizec F Andre Microbiol Immunol Scand 109 365 372
225. ATR IRAKLIKBA DAY TA VIB MAD AT 12 3 1 04946647 2012 03 16 4 5 6 1 2 3 4 5 6 1 Identification of Estrogenic Chemicals in STW Effluent 1 Chemical Fractionation and in Vitro Biological Screening C Desbwow E J Routledge G C Brighty J P Sumper M Waldock Environ Sci Technol 32 1549 1558 1998 Analysis of estrogenic hormones in municipal wastewater effluent and surface water using enzyme linked immunosorbent assay and gas chromatography tandem mass spectrometry C H Huang D L Sedlak Toxicol Chem 20 133 139 2001 Combination of automatic HPLC RIA method for determination of estrone and estradiol in serum T Yasui M Yamada H Kinoshita H Uemura N Yoneda M Irahara T Aono S Sunahara Y Mito F Kurimoto K Hara J Clin Lab Anal 13 266 272 1999 Rik AR PN 47 p 164 1998 Estrone and estradiol 1
226. B 0806 1 E IB fA B 0806 MA wm 20 24 78 6807 FA 956244 F 14 400 FA 20 E 5 lt 10 1 2 1 LAL
227. BTA 2 20 Immobilization Non immobilization TBTA MB 50 umol L 0 25 umol L P25 HE TB P25 HE 2 47 10 77 P25 SC AL TB P25 SC AL 0 41 1 14 1 66 b 0806 95 d dcSTX VERE 78 dcSTX dcSTX 10 UV UV 10 dcSTX UV dcSTX
228. Chem Soc Rev 40 754 770 2011 Novel separation medium spongy monolith for high throughput analyses F Watanabe T Kubo K Kaya K Hosoya J Chromatogr A 1216 7402 7408 2009 Stereospecific high affinity binding of 2 3 7 8 tetrachlorodibenzo p dioxin by hepatic cytosol Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase A Poland E Glover A S Kend J Biol Chem 251 4936 4946 1976 An overview of toxins and genes from the venom of the asian scorpion Buthus martensi Karsch C Goudet C W Chi J Tytgat Toxicon 40 1239 1258 2002 Botulinumtoxin Vom Gift zum Medikament Ein historischer Riickblick O P Kreyden M L Geiges R Boni G Burg Hautarzt 51 733 737 2000 Preparation of chromatographic sorbents with chiral cavities for racemic resolution G Wulff W Vesper J Chromatogr A 167 171 186 1978 Separation of amino acids peptides and proteins on molecularly imprinted stationary phases M Kempe K Mosbach J Chromatogr A 691 317 323 1995 Occurrence of 70 pharmaceutical and personal care products in Tone River basin in Japan N Nakada K Komori Y Suzuki C Konishi I Houwa H Tanaka Water Sci Technol 56 133 140 2007 Pharmaceuticals and personal care products in the environment what are the big questions A B Boxall M A Rudd B W Brooks D J Caldwell K Choi S Hickmann E Innes K Ostapyk J P Staveley T Verslycke Environ H
229. D Mobile Phase Pump for Sample Concentration LC 20AT Low Pressure Flow Change over Valve FCV 13AL Displacing solvent Water Rinsing solvent Methanol Samples Pretreatment Column Chemco MASK ENV Analytical Column Shim pack VP ODS High Pressure Flow Change over Valve FCV 12AH UV MS Detector or UV Detector LCMS2020 SPD 20A NO NN O MS SO IN cx O 1 1 2 1 SEHE 0 22 nm EAAS fre NA b 0806 4
230. M J Frechet Angew Macromol Chem 195 151 164 1992 Influence of the seed polymer on the chromatographic properties of size monodisperse polymeric separation media prepared by a multi step swelling and polymerization method K Hosoya J M J Frechet J Polym Sci Part A Polym Chem 31 2129 2141 1993 20 21 22 B 0806 23 Reducing Bisphenol A Contamination from Analytical Procedures To Determine Ultralow Levels in Environmental Samples Using Automated HPLC Microanalysis Y Watabe T Kondo H Imai M Morita N Tanaka K Hosoya Anal Chem 76 105 109 2004 Novel surface modified molecularly imprinted polymer focused on the removal of interference in environmental water samples for chromatographic determination Y Watabe K Hosoya N Tanaka T Kubo T Kondo M Morita J Chromatogr A 1073 363 370 2005 LC MS determination of bisphenol A in river water using a surface modified molecularly imprinted polymer as an on line pretreatment device Y Watabe K Hosoya N Tanaka T Kondo M Morita T Kubo Anal Bioanal Chem 381 1193 1198 2005 b 0806 24 2 x R amp D 20 24
231. Macroporous Spongy Monoliths T Tanigawa T Kubo K Hosoya Chem Lett 41 1265 1266 2012 Efficient Total Analysis for Bromine Type Flame Retardants by Simple NICI GC MS A Kobayashi T Kubo T Sato Y Kitahara S Amita M Mori S Suzuki K Otsuka K Hosoya Anal Methods 5 866 873 2013 b 0806 109 30 Antibacterial Activities Effectuated by Co continuous Epoxy based Polymer Materials T Kubo K Yasuda Y Tominaga K Otsuka K Hosoya Colloids Surf B 107 53 58 2013 31 Hybridization of Macroporous Sponge and Spherical Microporous Adsorbent for High Throughput Separation of Ionic Solutes T Kubo Y Tominaga K Yasuda K Hosoya K Otsuka Anal Sci 29 417 421 2013 32 Synthesis of poly ethylene glycol based hydrogels and its swelling shrinking properties responsive for molecular recognitions Y Tominaga T Kubo K Hosoya K Otsuka J Polym Sci Part A Polym Chem in press gt 1 3 MAR 2009 1 2008 2 MIRIA
232. O EVA25 OEVA25 HYD EVA15 PE SEDMA HGDMA SIL C18 log P Solute log P Benzene 2 33 benzene HPLC conditions Column size 100 mm x 4 6 mm 1 d Flow rate 1 0 mL min Mobile phase methanol water formic acid 40 60 0 1 v v v Temperature 40 C Detection UV 254 nm ee M PAH C do 5 benzo a pyrene BaP CE 8536 sedem niin operi Ads edm BaP 350 ml 2 0 mL min 23 BaP 2 34
233. PLC MS 100 ppt 89 MIP I b 0806 89 LC MS conditions column TSKgel Amide 80 150 mm x 2 0 mm i d mobile phase 100 mM formate buffer acetonitrile 2 8 flow rate 0 2 mL min detection ESI MS m z 342 temperature 40 C VINEIS Preconcentration 2 0 mL min 0 2 min washing with water 2 12 min 10 ppt sulpiride aqueous solution 12 14 min washing with acetonitrile 14 min start for elution sulpiride 20 2 72 SPB HPLC MS MS SPE HPLC
234. R Barro J Regueiro M Llompart C Garcia Jares J Chromatogr A 1216 540 566 2009 Analysis of industrial contaminants in indoor air Part 2 Emergent contaminants and pesticides C Garcia Jares J Regueiro R Barro T Dagnac M Llompart J Chromatogr A 1216 567 597 2009 Novel separation medium spongy monolith for high throughput analyses F Watanabe T Kubo K Kaya K Hosoya J Chromatogr A 1216 7402 7408 2009 Retention properties of macroporous spongy monolith and its application for concentration of polyaromatic hydrocarbons T Tanigawa K Kato Y Watabe T Kubo K Hosoya J Sep Sci 34 2193 2198 2011 Specific Chromatographic Retentions on Polymer Pore Surface of Macroporous Spongy Monoliths T Tanigawa T Kubo K Hosoya Chem Lett 41 1265 1266 2012 Effective recognition on the surface of a polymer prepared by molecular imprinting using ionic complex Y Tominaga T Kubo K Kaya K Hosoya Macromolecules 42 2911 2915 2009 Surface modification of T1O2 for selective photodegradation of toxic compounds Y Tominaga T Kubo K Hosoya Catal Commun 12 785 789 2011 LC MS determination of bisphenol A in river water using a surface modified molecularly imprinted polymer as an on line pretreatment device Y Watabe K Hosoya N Tanaka T Kondo M Morita T Kubo Aanl Bioanal Chem 381 1193 1198 2005 30 31 32 33 34 35 36 37 38 39 40 41
235. T Kubo K Otsuka The 6th Shanghai International Symposium on Analytical Chemistry Shanghai China October 2012 Invited Speaker 22 High selective separation of pharmaceuticals and personal care products PPCPs by the molecularly imprinted polymer adsorbents T Kubo K Hosoya K Otsuka PITTCON2013 Philadelphia USA March 2013 Poster b 0806 112 23 Development of novel hydrogels responsive for molecular recognition Y Tominaga T Kubo K Otsuka K Hosoya PITTCON2013 Philadelphia USA March 2013 Poster 24 Selective preconcentration and determination of a PPCP sulpiride in river water by an online SPE LC MS using a molecularly imprinted adsorbent T Kubo K Kuroda K Hosoya K Otsuka HPLC2013 Amsterdam Netherlands June 2013 scheduled gt D MAR 69 2008 5 2 A find MAB 15 2008 425 3 MAR 57 2008
236. ation of Silica C18 Packing Materials Correlation between a Preparation Method and Retention Behavior of Stationary Phase K Kimata K Iwaguchi S Onishi K Jinno R Eksteen K Hosoya M Araki N Tanaka J Chromatogr Sci 27 721 728 1989 PCB 3 23 3 Selective retention of some polyaromatic hydrocarbons by highly crosslinked polymer networks K Hosoya H Aoki T Kubo M Teramachi N Tanaka J Haginaka J Polym Sci Part A Polym Chem 43 2556 2566 2005 Affinity chromatography G R Gray Anal Chem 1980 52 9 15 1980 Effect of the direction of ester linkage on molecular shape selectivity through multiple carbonyl a interaction with octadecyl chain branched polymers as organic phases in reversed phase high performance liquid chromatography A A Rana M Takafuji H Ihara J Chromatogr A 1216 7440 7445 2009 b 0806 122 Development of Selective Removal Technique of Environmental Pollutants Using Template Molecule Mimics Principal Investigator Ken HOSOYA Institution Kyoto Prefectural University 1 5 Hangi cho Shimogamo Sakyo ku Kyoto 606 8522 Japan Tel 81 75 703 5444 Fax 81 75 703 5444 E mail hosoya kpu ac jp Cooperated by Kyoto University Shimadzu Corporation Kaneka Corporation Abstract Key Words Column switching Auto concentration Environmental chemicals Instrumental technology High
237. bo Yuichi Tominaga Ken Hosoya MIP 2008 Kobe Japan September 2008 2 High throughput on line concentration by novel separation media named Spongy monol i th Takuya Kubo Fuminori Watanabe Ken Hosoya HPLC2008 Kyoto Kyoto Japan December 2008 3 Selective adsorption and degradation of toxic compounds by organic inorganic hybrid material Takuya Kubo Yuichi Tominaga Ken Hosoya The Second French Research Organizations Tohoku University Joint Workshop on Frontier Materials Sendai Japan December 2009 Invited Speaker 4 Development of molecularly imprinted polymers enabling selective adsorption for gaseous compounds Y Tominaga T Kubo K Hosoya ICAS2011 Kyoto Japan May 2011 b 0806 viii 5 The basic study of spongy monoliths and its applications T Kubo K Kato T Tanigawa Y Watabe Y Tanaka K Hosoya ICAS2011 Kyoto Japan May 2011 Invite Speaker 6 Effective separation and photodegradation of water soluble toxic compounds by the molecularly imprinted adsorbents T Kubo K Otsuka The 6th Shanghai International Symposium on Analytical Chemistry Shanghai China October 2012 Invited Speaker lt BAS 1 EISE MRE 15 2008 5 2 AR
238. de MIP E NIP LC Conditions Column size 100 mm x 4 6 mm i d Flow rate 0 5 mL min Detection UV 272 nm or 254 nm Temperature 40 C N N Bis 2 hydroxyethyl 2 aminoethanesulfonic acid Retention factor k 2 70 sulpiride MIP NIP a acetonitrile 50 mM formate buffer pH3 0 8 2 b acetonitrile 50 mM BES NaOH buffer pH 7 0 8 2 c acetonitrile 2 19 pK log PIE sulpiride aniline N N dimethylaniline pK 10 2 4 67 5 39 pK 9 00 log P 1 34 0 90 2 38 2 711 2 b 0806 88 MIP I mhexylbenzne E aniline sulpiride DMA sulpiride MIP I NIP I Absorbance mAu EN C
239. ds Y Tominaga T Kubo K Hosoya ICAS2011 Kyoto Japan May 2011 Oral 14 The basic study of spongy monoliths and its applications T Kubo K Kato T Tanigawa Y Watabe Y Tanaka K Hosoya ICAS2011 Kyoto Japan May 2011 Invite Speaker 15 Improvement of adsorption capacity on spongy monolith K Kato T Kubo K Hosoya ICAS2011 Kyoto Japan May 2011 Poster 16 Basic study of macroporous spongy monolith on HPLC separation and its application for effective concentration of PAHs T Kubo T Tanigawa K Kato Y Watabe Y Tanaka K Hosoya HPLC2011 Budapest Hungary June 2011 Poster 17 Polymer based photocoupling agent for the efficient immobilization of nanomaterials including nanoparticles and graphene T Kubo M Yan IACIS2012 Sendai Japan May 2012 Poster 18 Mystery of molecular recognition ability on surface of polymer based macroporous media T Tanigawa T Kubo K Hosoya IACIS2012 Sendai Japan May 2012 Poster 19 Wa shi Japanese paper fabrics as adsorbents K Hosoya Y Ohizumi Y Sakai T Kubo SETAC2012 Berlin Germany May 2012 Poster 20 Investigation of swelling and shrinking properties of polyethylene glycol based hydrogel and its application to MIP for DDS Y Tominaga T Kubo K Hosoya K Otsuka MIP 2012 Paris France August 2012 Poster 21 Effective separation and photodegradation of water soluble toxic compounds by the molecularly imprinted adsorbents
240. ealth Perspect 120 1221 1229 2012 Comment on Feather Meal A Previously Unrecognized Route for Reentry into the Food Supply of Multiple Pharmaceuticals and Personal Care Products PPCPs B J Kelly Environ Sci Technol 46 13024 13025 2012 17 18 19 20 21 22 23 24 25 26 27 28 29 B 0806 120 Feather meal A previously unrecognized route for reentry into the food supply of multiple pharmaceuticals and personal care products PPCPs D Love R Halden M Davis K Nachman Environ Sci Technol 46 3795 3802 2012 Overview of passive Chemcatcher sampling with SPE pretreatment suitable for the analysis of NPEOs and NPs H Ahkola S Herve J Knuutinen Environ Sci Pollut R 20 1207 1218 2013 Occurrence and removal of pharmaceutical and hormone contaminants in rural wastewater treatment lagoons X Li W Zheng W R Kelly Sci Total Environ 445 22 28 2013 Less common applications of monoliths Preconcentration and solid phase extraction F Svec J Chromatogr B Biomed Appl 841 52 64 2006 Extraction and clean up strategies for the analysis of poly and perfluoroalkyl substances in environmental and human matrices S P J van Leeuwen J de Boer J Chromatogr A 1153 172 185 2007 Analysis of industrial contaminants in indoor air Part 1 Volatile organic compounds carbonyl compounds polycyclic aromatic hydrocarbons and polychlorinated biphenyls
241. ee 10 mL 15 PAHs 11000 1 000 2 wo 11 9 000 7 8 12 00 14 6 10 13 A 4000 5 2000 1000 0 5 10 15 20 25 30 Al A2 A3 44 AS A6 M 2 36 PAHs 1 naphthalene 2 acenaphthene 3 fluorene 4 phenanthrene 5 anthracene 6 fluoranthene 7 pyrene 8 benzolalanthracene 9 chrysene 10 benzo b fluoranthene 11 benzo k fluoranthene 12 benzo a pyrene 13 dibenz a h anthracene 14 benzo g h l perylene 15 indeno 1 2 3 cd pyrene HPLC condition Pretreatment column EVA spongy monolith 50 mm x 4 6 mm i d Temperature 40 C Detection fluorescence wavelength switching as follows initial Ex Em 270 330 nm 17 5 min 250 370 nm 19 5 min 330 430 nm 21 min 270 390 nm 23 min 290 430 nm 25 5 min 370 460 nm 28 min 270 330 nm Mobile phase water acetonitrile gradient elution gradient profile
242. esults will be applicable for the simple quantitative analyses and removal technologies of the environmental pollutants yz CHEMCO MASK ENV MASKED LC MS y RRMA JUR ER Skea 7 8 A YREM II B superior effect om removal of CHEMCO MASK ENV71 7 4 CISMASKMERDIA REB Lom N interference at UV275nm papas
243. etermination of bisphenol A in river water using column stitching HPLC with fluorescence and mass spectrometry detection Y Watabe T Hine H Mikami T Kubo K Hosoya T Tanigawa International Symposium on Separation Science Rome Italy September 2010 Poster 5 Ultra low level determination of bisphanol A in river water using column switching HPLC with fluorescence and mass spectrometry detection Y Watabe T Hine T Tanigawa T Kubo K Hosoya ICAS2011 Kyoto Japan May 2011 Poster 6 Ultra low level determination of bisphenol A and poly aromatic hydrocarbons in river water using column stitching HPLC with fluorescence detection Y Watabe T Hine T Tanigawa T Kubo K Hosoya HPLC2011 Budapest Hungary June 2011 Poster 7 Ultra low level determination of bisphenol A 17 estradiol and poly aromatic hydrocarbons in river water using fully automated column stitching HPLC Y Watabe Y Hayakawa T Tanigawa T Kubo K Hosoya SETAC2012 Berlin Germany May 2012 Poster 8 Easy and high sensitivity determination of chemical pollutants in river water by using fully automated column switching HPLC Y Watabe A Nomura Y Hayakawa T Tanigawa T Kubo K Hosoya HPLC2012 Anaheim USA June 2012 Poster 9 Trace level determination of polycyclic aromatic hydrocarbons in river water with automated pretreatment HPLC Y Watabe Y Hayakawa T Kubo T Tanigawa K Hosoya ISC2012 Torun Poland September 2012
244. initial 4 6 v v 14 min 6 4 22 min 0 10 36 min 0 106 flow rate analytical 1 5 mL min pretreatment 1 0 mL min Sample PAHs spiked Kamo river water in Kyoto Injection volume 10 0 uL Sample concentration No 2 3 4 7 8 12 13 14 15 10 ng L No 5 6 9 10 11 20 ng L No 1 13 100 ng L Column Restek Pinacle II PAH 250 mm x4 6 mm 1 d g BEEN A es LAL t 2 37
245. l PEG gel PEG gel lysozyme 1ysozyme 14 307 11 1 11 4 Asp7 Glu2 Argll Lys6 SSA PI gel 2 21 PI gel lysozyme PI gel 1ysozyme T Lysozyme UV Vis spectrophotometer PI gel lysozyme PI gel lysozyme X 2 92 PI gel 1ysozyme
246. l ADVN 200 mg 200 mg 200 mg 190 mg 190 mg 190 mg 200 mg 200 mg 200 mg 190 mg 190 mg 190 mg B 0806 43 d flot 2 1 a LY GDMA 5 0 mL toluene 5 0 mL ADVN 0 15 ge fdv 70 C 24 XK methanol tetrahydrofuran b 2 0 g methanol 100 mL 0 75 g ADVN 70 C 24 methanol N N dimethylamino ethylacrylate methyl chloride quarternary DMAEA Q
247. mated Pretreatment HPLC Y Watabe T Kubo T Tanigawa Y Hayakawa K Otsuka K Hosoya J Sep Sci 36 1128 1134 2013 gt D 5803 Herb tise WAR 2008 1 LCMS VERB Lae 10 4 2010 2 lt gt 1 Improved technique of pretreatment method for environmental water analysis using column switching LC MS Tairo Ogura Yoshiyuki Watabe Tomio Fujita Takuya Kubo Ken Hosoya Kunimitsu Kaya HPLC2008 Kyoto Kyoto Japan December 2008 Poster 2 Analysis of trace components in environmental water by automated column switching LC MS system Tairo Ogura Yoshiyuki Watabe Hirohisa Mikami Tomio Fujita Takuya Kubo Ken Hosoya Kunimitsu Kaya PITTCON 2009 Chicago USA March 2009 Poster b 0806 19 3 Automated determination of bisphenol A 17 5 estradiol and wasted drugs in river water with multi valve column switching LC MS in river water with multi valve column switching LC MS Yoshiyuki Watabe Tairo Ogura Tomio Fujita Takuya Kubo Ken Hosoya Kunimitsu Kaya HPLC2009 Dresden Germany June 2009 Poster 4 Ultra low level d
248. n method T Mori T Kubo K Kaya K Hosoya Colloid Polym Sci 287 513 523 2009 Nostoc commune Aphanothece sacrum BMAA B N methylamino L alanine EFE EPF 153 176 179 2009 Effective Recognition on the Surface of a Polymer Prepared by Molecular Imprinting Using Ionic Complex Y Tominaga T Kubo K Kaya K Hosoya Macromolecules 42 2911 2915 2009 Properties of A Non Aromatic Epoxy Polymer Based Monolithic Capillary Column for u HPLC T Mori T Kubo M Sakamoto K Kaya K Hosoya Chromatographia 70 699 704 2009 Spontaneous Water Cleanup Using an Epoxy Based Polymer Monolith T Kubo Y Tominaga K Yasuda S Fujii F Watanabe T Mori Y Kakudo K Hosoya Anal Methods 2 570 574 2010 Novel Separation Medium Spongy Monolith for High Throughput Analyses F Watanabe T Kubo K Kaya K Hosoya J Chromatogr A 1216 7402 7408 2009 Novel Polymer Monolithic Column for Hydrophilic Compounds T Kubo F Watanabe N Kimura K Kaya K Hosoya Chromatographia 70 527 532 2009 19 20 21 22 23 24 25 26 27 28 29 b 0806 108 Co continuous Monolithic Titania Prepared by Organic Polymer Monolith as Pore Template Material Letters T Kubo N Tsujioka N Tanaka K Hosoya Mater Lett 64 177 80 2010 Bi Continuous Macroporous Polymer Derived
249. nzyl alcohol phenol methyl benzoate Retention factor k 20 30 40 50 60 70 80 100 2 59 acetonitrile GDMA 6 benzene 29 toluene fil benzoic acid FE benzyl alcohol te phenol methyl benzoate Retention factor k 20 30 40 50 60 70 80 90 100 60 acetonitrile DMAEA Q 10 m 8 benzene 8 6 toluene 1 f benzoic acid benzyl alcohol e 2 t phenol fe methyl benzoate 20 30 40 50 60 70 80 90 100 2 61 acetonitrile MPC 2 a 12 r R 0 975 ABS 0 00 0 02 0 04 0 06 0 08 0 10 g 2 62_ Br b 0806 81 ContP
250. performance liquid chromatography Molecular imprinting Interval immobilization technique Poly chlorinated biphenyl Pharmaceutical and personal care products Spongy monolith In this study to develop a selective simple analysis and removal technology of environmental pollutants we studied along two subthemes 1 Practical application for high sensitive analytical system and 2 Development and practical application of separation membrane having selective adsorption ability Especially compounds such as halogenated aromatics such as poly chlorinated biphenyl PCBs polycyclic aromatic hydrocarbon PAHs and highly hydrophilic compounds including pharmaceuticals and personal care products PPCPs were considered as the target compounds The molecularly imprinted media that enable the selective adsorption for these targets were developed Also we utilized these media for the sensitive analytical system and the removal technology In the study 1 we developed multi valve column switching HPLC system with a specially designed pretreatment column and achieved the commercialization of the product In the trace level analyses of environmental samples we confirmed trustable repeatability and sensitivity even with general detectors such as a photo diode array and fluorescence detector The system allowed the simple versatile and reliable quantitative analyses of chemical substances in environmental water The subtheme 1 was performed by coope
251. ration with Kyoto University and SHIMADZU CORPORATION In the study of 2 we developed two type molecularly imprinted media for the organic compounds and highly hydrophilic compounds which are hard to be separated b 0806 123 and concentrated As the media for the organic compounds we aimed to separate PAHs including benzo a pyrene and PCB For similar objective we also developed novel spongy monolith which has macroporous structure and consisted of poly ethylene co vinyl acetate Secondly for the highly hydrophilic compounds we aimed to develop the media for a shellfish poison saxitoxin a medicine sulpiride and a protein lysozyme As the selective separation concentration media for these hydrophilic compounds we established the interval immobilization technique The subtheme 2 was performed by cooperation with Kyoto University and KANEKA CORPORATION Finally as the accomplishment of study 1 and 2 we applied the column switching HPLC system for the analysis of real environmental samples to determine PAHs and sulpiride As a result of analysis for PAHs 15 ingredients of PAHs were determined at ng L levels with excellent repeatability and sensitivity Similarly as a result of the analysis for sulpiride we successfully achieved the determination of sulpiride from river water sample by an online SPE HPLC MS system with the separation medium prepared by the interval immobilization technique These applications promise that our r
252. ume 10 uL MS conditions dcSTX Ionization ESI Polarity Positive Interface voltage 4 5 kV Interface temperature 200 C CDL voltage 50 V CDL temperature 250 C Heat block temperature 200 C Drying gas 0 1 Mpa Nebulizer gas N gt 1 5 L min Monitoring SIM 257 m z D 0806 49 5 a EDMA LAP 0 5 10 15 20 25 methanol 0 5 10 15 20 25 methanol aq 100 ppm BPA 25 methanol aq 9G 9G 09 9G 30 TEGVE TEGVE 0 TEGVE 30 0 30 Z 0 30 Epoxy 26 1 Epoxy 26 2 Epoxy 26 1 0 Epoxy 26 1 30 Epoxy 26 2 096 Bpoxy 26 2 30 26 Epoxy 26 1 1 0 um Epoxy 26 2 2 0 3 0 um b BPA 3 0 mg 10 mg 20 mL 100 ppm BPA 20 mL 1 25 5 C
253. yls Y Tominaga T Kubo A Kobayashi K Yasuda K Kato K Hosoya Chemosphere 89 378 382 2012 10 Development of Molecularly Imprinted Porous Polymers for Selective Adsorption of Gaseous Compounds Y Tominaga T Kubo K Yasuda K Kato K Hosoya Micro Meso Mater 156 161 165 2012 11 AEF 61 371 381 2012 12 Specific Chromatographic Retentions on Polymer Pore Surface of Macroporous Spongy Monoliths T Tanigawa T Kubo K Hosoya Chem Lett 41 1265 1266 2012 13 Trace Level Determination of Polycyclic Aromatic Hydrocarbons inRiver Water with Automated Pretreatment HPLC Y Watabe T Kubo T Tanigawa Y Hayakawa K Otsuka K Hosoya J Sep Sci 36 1128 1134 2013 14 Hybridization of Macroporous Sponge and Spherical Microporous Adsorbent for High Throughput Separation of lonic Solutes T Kubo Y Tominaga K Yasuda K Hosoya K Otsuka Ana Sci 29 417 421 2013 15 Synthesis of poly ethylene glycol based hydrogels and its swelling shrinking properties responsive for molecular recognitions Y Tominaga T Kubo K Hosoya K Otsuka J Polym Sci Part A Polym Chem in press 2 gt 1 Effective molecular recognition for ionic compounds by the interval immobilization technique Takuya Ku

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