シクロスポリン - 積水メディカル株式会社
Contents
1. Aw NM 6 A 20 2 25ng mL 80 120 10 7170 25 450ng mL 450 2000ng mL N 118 r 0 976 y 0 95x 11 782. 2 8 EA ED
3. AM1 3 6 AM9 18 AM4n 16 AM19 0 35 AM4N9 1 2 AMI1c 1 2 N lt 0 015 lt 0 015 lt 0 015 lt 0 015 lt 0 015 lt 0 015 lt 0 015 lt 0 015 lt 0 015 lt 0 015 lt 0 015 lt 0 015 lt 0 015 lt 0 015 lt 0 075 lt 0 015 0 015 0 015 lt 0 015 lt 0 015 lt 0 015 lt 0 015 lt 0 015 lt 0 015 lt 0 015 lt 0 015
4. 01 1 121C 20 0 1
5. 15 30C 1 2 8 C 4 70C 2 1 60mg dL 1000mg dL 20mg dL 10g dL 10g dL to 2 3 305 53 5
6. 6 12 1 CEDIA Cloned Enzyme Donor hmmuno assay Enzyme Donor ED Enzyme Acceptor EA ED EA ED D CPRG
7. 1 2 2 8C 2 x 0120 249 977 FAX 0120 247 477 3 98mL x1 i EA 41mL x1 EA 41mL x1 ED 19mL x1 ED 19mL x1 A 25mL x1 B 25mL x1 A 4mL x1 B 4mL x1 1 2 3 4 10 11 12 Fowler A Zabin L Amino acid sequence of galactosidase J Biol Chem 253 5521 5525 1978 Henderson D R Friedman S B Harris J D Manning W B Zoccoli M A
8. ED gt EA ED EA ED EA ED CPRG CEDIA Cloned Enzyme Donor Immunoassay 2 1 2 0 25 450ng mL 450 2000ng mL 3 2 4 1 1 EDTA 2K
9. 1 1 HIV HBV HCV HBs HTV AIDS HCV 2 3 2 1 3 4 5 7 8 3 1 2 4
10. a 450 2000ng mL 4 1 2
11. 6 EA EA EA ED ED D ED A B A B T 3 59
12. J EA EA ED ED 5 13 5 saz Microgenics Corporation 46500 Kato Road Fremont CA 94538 USA
13. 25ng mL 25ng mL 1 2 EA EA ED ED 2 8 60 3 MM 1 100 7L 400L 2 5 15 25 1 5 2 3 9 37 25uL 225uL 5 37C 100L 247 300 gt 660nm 570nm
14. lt 0 015 lt 0 025 lt 0 015 lt 0 015 lt 0 015 lt 0 015 0 015 lt 0 015 lt 0 015 lt 0 015 lt 0 015 G lt 0 015 lt 0 015 lt 0 300 lt 0 030 3 1 25 450ng mL 450 2000ng mL A B 2 3 2000ng mL EDTA 1 1
15. 970853 005 13A2X00197218053 2015 5 5 2008 4 4 30419000 1 2 3 4 5
16. CEDIATM A New Homogeneous Immunoassay System Clin Chem 32 9 1637 1641 1986 Britton S Palacios R Cyclosporine A Usefulness risks and mechanism of action Immunological Review 65 5 1982 Keown P A Essery G L Stiller C R Sinclair N R Mullen R Ulan R A Mechanisms of immunosuppression by cyclosporine Transplantation Proceedings 13 1 386 1981 White D J G Cyclosporine A clinical pharmacology and therapeutic potential Drugs 24 332 1981 Barton C H Vaziri N D Cyclosporine nephrotoxicity International J of Artificial Organs 8 291 296 1985 Myers B D et al Cyclosporine nephrotoxicity N Engl J Med 311 699 705 1985 Atkinson K et al Transplantation Proc 15 2761 1983 Hows J M Chipping P M Fairhead S Smith J Baughan A Gordin Smith E C Nephrotoxicity in bone marrow transplant recipients treated with cyclosporine A Br J Haematol 54 1 69 78 1983 Kahan B D Wideman C A Reid M Gibbons S Jarowenko M Flechner S Van Buren C T The value of serial serum trough cyclosporine levels in human renal transplantation Transplantation Proc 16 5 1105 1199 1984 Keown P A et al Transplantation and clinical immunology In Toursime J L ed Exerpta Medica 13 34 1981 Bowers L D Canafax D M Cyclosporine Experience with therapeutic monitoring Therapeutic Drug Monitoring 6 2 142 147 1984
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