[ケーススタディ報告書] スーパーグロース単層
Contents
1. 2011 8 PO06041 FMB 3 1 x lt H NEDO 8 5 HORSE C 152. D CNT OPC 0 3 10pm
3. SO OECD NanoSafety hmp www nanosafety jp twitter Nanosafety ISO SO TC229 2013 4E 1 1 OECD OECD EHS WPMN 2013 3
4. KC 3 10 x 47 50 47 50 4 100 Tz 4 25 47 25 Xo a sica 10 LAST 50 50 100 25 25 P DUM CAE E 50 1000 1000 e 10 u P 2 50 5000 oi gt Lm Lf
5. m Es CNT CNT CNT CNT SDS
6. 223 D 2 A H 9 ISO 12103 1 Al test Dust TSI Dusttrak II 8530 880 nm 1H microAeth Model AES1 5
7. P10024 42 ia National Institute of Advanced Industrial Science and Technology AIST TASO Research Institute of Single Wall CNT Science for Safety and Sustainability INEDO IP10024
8. ICAM y B ICE C HRE SOD 7 HA ZR e SD 0 04 2 mg kg E mg kg EL E i BALF BALF LDH 18 IL 18 0 04 mg kg 6
9. 1B ISO 229 ISO TS 12025 ISO TC229 Z4 M2 X8 VR E DES n Z EE to 2001 4
10. CNT t IE 2 CAS 308068 56 6 3 1 E 1 SG CNT KS TEM 128 n 170 3 03 1 1 nm BET N n 10 1064 37 mg UREA TGA 99 ICP MS Al Fe Ni 4 LT
11. CNT TASC 10 NEDO TASC TASC f
12. 1 b A AX ri H 1 CNT 4 TARR in Jok 2 CNT 4 vitro
13. CNT CNT 1
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16. 11 SG CNT I pend xh i UR ym 1 24 48 72hr OECD TG406 Slc Hartley m i 2 i EO de Buehler HE 4 Ag e lt gt Pietroiusti 2011 CDI SG 76 je 3 FON fuss H Hv v ACH Aik OA AVE METRE DSB StL HEIN 12 100 ng Fujitani 2012 2 mg kg 4 mg kg Roman 2013 25 ugik 16 CNT Cheap Tubes Inc p SW
17. CNT CNT CNT HEPA GEV TIRE COT CNT
18. 14 FE p gie A EAR PIE H CNT 3 CNT in vitro CNT BER CNT CNT 1 JOJ in vitro CNT RS el X REETIKA B Ei ZH SCR E BSA CASE eu fli
19. m 6a aes ee wm sm 3 A B B REO ARE REE CNT 28 30 LD gt 50 mg kg NOAEL 12 5 mg kg 0 03 mg m aes RES
20. HOQ 2 UAZXURCHXEAS HQ 1 HO 1 1 HQ gt 1 0331013 K E 29 21 3 31 NI
21. XE I E CNT Be lt gE TRER LU DNA CHEV gt 4 9 FE Fi
22. 2 1 A OH B a BE e Y b MITI OECD TG 301C GLP 100 mg L 30 mg L 28 BOD DOC 0 OECD TG301F GLP 100 mg L 30 mg L 28 BOD DOC HI
23. CNT 1 f CNT E CNT Ex CNT Of f amp 3o EO FPL 25 TA CNT CNT 32 i a f T CNT
24. 107 50 ug m ng m B 2
25. LE 2 1 HO _ mg m is 0 03 mg m3 II 3 BRP 1 C OEL 0 03 mg m
26. ui 0 03 mg m H E 0 03 mg m SREDA 3 8 E 2 J gt CNT ERE HR ISO
27. ji METI 2 8 RS E 4 BU SEPARARE DNA ZRT 23 deoxyguanosine dG 8 knik DNA OPC PBS REL ROS S9 SA SDS SEM SG SMPS SOD TASC TEM TG TGA TWA UV WG3 WPMN tail DNA Optical Particle Counter Phosphate Buffered Saline Recommended Exposure Limit Reactive Oxygen Species Supernatant of liver homogenates after centrifuged at 9000 X g Surface Area of lung Safety Data Sheet Scanning Electron Microscope Super Growth Scanning Mobility Particle Sizer Superoxide dismutase Technology Research Association for Single Wall Carbon Nanotubes Transmission Electron Microscope Test Guideline Thermo Gravimetry Analyzer Time weighted average Ultra Violet WG3 of ISO TC229 Health Safety and Environment USA convenor Working Party on Manufactured Nanomaterials EX ER 5 Hr
28. SG CNT TASC 3 CNT TASC INEDO lt gt Email tasc3 ml aAist go p 2015 3 lt gt E CNT ORO lt pee gt mn CNT Hd CNT D Tix CNT
29. 3 2 3 TW 2012 4E 12 H 2014 6 H 2015 3 H 1 2 A KARE a b c B Fee REI CPP Ck m BERK DE 3 TE Be ae We ee oe ee ee ee 1 2 I 1
30. ng m v ugm E Vy c CNT OPC b
31. BCF 3 SG CNT x CNT s RE BCF m B mg L lt GLP gt OECD TG305 60 px PR pe Cyprinus carpio 0 050 lt CNT gt Parks 5 2013 Ampelisca abdita Americamysis bahia CNT SG65 SouthWest Nano Technologies 7 CNT N NS ON gi 2 BRHiTh OE X A KEAWICMT OR a EACH TS ETE fk Pseudokirchneriella subcapitata 72 WEAR RAE AER OECD TG201 GLP 1 0 3 2 10 mg L 5 1 16 46 50 ECso
32. SG CNT 1 HL hh 4 PF f 10 mg L 2 46 1 mg L 21 4 11 gt EZ LAY A
33. CHP AAR LN VICK L ERO AREER VETE V FE hem 10 mg L 72 HERR aie sp 1 E a E A B E 36 6 E
34. T OELy NOAELg X i 5 AF retained dose E AF kinetics AF retained dose AF deposited dose AF AM volume Sx si x AF kinetics Qr DFR AM AMyoin 0314m day kg 0 118 10 10 29 m3 day kg 0 057 5 x 1011 8 7 x 1019 1 2 x 5 7 1 OELy 0 1 x 2 0 05 mg m OBL mgm AF retained dose AF deposited dose EL i TED AF kinetics CNT tj 60 tz 1 10 AFam volume
35. 15 D CNT t 4 4 eh A OF i Bm 80 m zi fo ae E 2 GU E 60 parar ao lt 3 RRR EO m A CO CH B 40 amp 0 40 80 120 A R ha a Pim gt 20 ug m CNT DRE 900 0 15 60 75 15 CNT 09 2 CNT
36. 3A CNT 3 7 E m FEL RE L 3B 1 CNT 12 nm CNT CNT 3 nm 4
37. OEL 0 03 mg m 30 4 4 um 50 OEL BE CNT
38. ii 6 1 6 1 i 100 cm 1 3 gs Uh 30 cm CK ii CNT CPC OPC 1 A 24 K Uh CNT 100 cm fec Ja0cm PLR 280X370X272 mm 26L 58 L min
39. 1 CNT D NEDO PO6041 0 03 mg m 1 8 5 15 4 NOAEL 2 5 Z 2 CNT 10
40. 4 4 2 CNT CNT
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42. 3 BW J SASAi BWg BWi HFE SAp SAy BWyBWg BWs 0 3 kg BWg 73 kg NOAELy NOAELg X tr x dayg Qn DFg BW 1 ty X dayy Qu DF BWg UE 7 E 6x60x5 0 189 x 1073 VOS 0 x X X 1 8 x 60 x 2 25 x 1073 0 3 3 0 029 0 03 mg m t MERIAH
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44. n Aerodynamic Particle Sizer APS 72 72345 B CNT CNT 1 SEM Af FTE CRF TS
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47. e 4 NEDO P06041 CNT 2492 4 NOAEL 0 13 mg m 3 2 3 NOAELs 0 065 mg m NOAEL 1
48. 95 CNT 2013 10 31 1 0D CNT in vitro fd 1 CNT
49. TASC SG CNT CNT CNT SG CNT CNT CNT CNT
50. 1H 3 BMD BMDS2 1 2 10 0 00019 0 0019 mg m 2 n E J 95 ji REL amp L7z 0 001 mg m IX ERR X NEI XE SIVA ACH V NIOSH NIOSH 5040 0 001 mg m A O 14 CNT mg m NEDO CNT 0 03 1 8 5 15 lt gt
51. 13 CNT CNT CNT 59 principal material AH I 2 OECD 33 CNT CNT 2015 3 A VS 2 SO
52. E LJ zB ER 3 2009 3 2012 9 VOR ILM RAT BTA VY 8
53. 10 NIOSH CNT CNF 0 001 Recommended Exposure Limit REL TWA ENRHES CNT 0 0007 0 03 Derived No Effect Level DNEL 54 Bayer CNT 0 05 Occupational Exposure Limit OEL Baytubes gt TWA Nanocyl CNT 0 0025 lt NC7000 gt 1 1 20 3 amp SE SE 1 A CNT CNT optical particle counter LAF OPC
54. ECs gt 100 mg L 8 SG CNT isi in E mS dE E is HE mg L EMER lt GLP gt ou x 3 100 D gt 100 OECD TG209 TUS mg 3 A ADME lt gt Liou 5 2012 I 5244 SiO 37 94 TiO 227 CNT 19 1 10 f NA 137 NG
55. ZIA 0 3 10 um HH 5 X b nili D WAAT R EO condensation particle counter CPC 0 01 1 um OPC OPC o
56. 12 CNT 13 CNT SEM 28 II TASC gt
57. CNT CNT CPC 10nm cm CNT 100 nm Low Pressure Impactor ELPI 72 72345 xz 0 5 10 um Fast Mobility Particle Sizer FMPS Electrical Scanning Mobility Particle Sizer SMPS
58. ARERR 327 A x sisa b lt CNT gt Matsumoto 2012 CNT 92 SD 2350 mg kg 1 MES LD gt 50 mg kg SD 0 125 1 25 12 5 mg kg 28 NOAEL 12 5 mg kg 5 ug NZW RHE 1 72 0 5 g NZW RHE iB OECD TG405 BC 185
59. CNT CNT CNT NEDO BASF f E NIOSH WS lt 1 NEDO 7 CNT gt CNT CNT MWCNT N 18 Ss JV TE AAR AER DARD D MWCNT N TEXSPRES PPA ARB IRE ERLT MWCNT N 4 NOAELa 0 37 mg m NOAEL 1 8 5 AOR 15
60. 13 2 D gt ENS 57 6 i iij 1i 9 7 8 CPC 0 01 gt 1 pm 1 S rH 5 TE TRE i i E po H f i amp i TIE ES 3 i i 1 1 lE C j H op P H et Wi ii i i E aa a 16 04 16 12 1619 1626 16 33 16 40 16 48 1655 1702 17 09 ngn c O50 i E i 2 040 E El Mi ji 030 nn i IR nn A i 2x o oo Ai i i i i NE IE EE Y Ade 16 04 16 12 16 19 1626 16 33 16 40 16 48 1655 1702 1709 0010 0009 z 0008 go 4 0006 x 0 005 a 0 004 0 003 WX 0 002 0 001 000 P Nw Ww L 1 16 04 16 12 1619 1626 16 33 16 40 1648 1655 17 02 17 09 7 10 CPC OPC 7 CPC OPC BEKO CPC lt 10 cm OPC lt 1
61. CHE CES PUER LC PALES P bos Mr o CRLF EETA 72 UOTE 11 13 80 nm 25 mmp 3 8 cm 03 0 5 L min CHIE PARDEE ETES EH EL TEM TEM 2 CO gt CHL CNT 2224 C a b ugh 2 AE
62. 3 cm s fem 25 lt 0 01 mg m 1 C b lt 0 007 mg m 0 03 mg m 1 B 1 SEM CNT 8 8 SEM b HP KAAR 9
63. 20 ECs gt 1 0 mg L NOEC 0 32 mg L 12 j 5 SG CNT E ius mg L lt GLP 2 ae 48 0 42 0 94 100 mg L ECs5o asnr 5 EOD IG202 Daphnia magna 2 1 4 5 10 HCO 40 mg L EC 9 i 50 21d L Hed Seid zi 21 0 a 1 10 mg L re mg L aS OTE ERM ERE REREE p t E ERES OECD TG211 Daphnia magna 4 0 32 1 0 Tween 80 NOEC 314 0 32 mg L c Oryzias latipes 96 OECD TG203 GLP 10 mg L 50 LCs gt 10 mg L Oryzias latipes 14
64. 30 23 R8 OO PET KA IAA AER amp 3 SMPS OPC APS SMPS OPC APS 10 1 B 1 SEM 10 nm 11 0 002 mg m 1 C b lt 0 01 mg m 0 03 mg m 26
65. FD IE SG CNT 2015 3 HH AE DI 3E FH Imm TASC 800 C Ho H
66. C a ARIS BIT SRE b c a 4 NOAEL 0 13 mg m NOAEL NEDO PO6041 CNT NOAEL 1 8 ID ERR 15 0 03 mg m
67. CPC 001 1 um 3 3 21 HA S
68. 9 D I A549 in vitro II AS49 48 S 0 1 mg mL TEM ROS
69. Wee 7 A 3e BER a La E OECD TG404 BREK 1 72 X 10 SG CNT 1 24 48 72hr 1 mL Kbl NZW AR gases Mo MOR RIE ZR as ESTE EE LES OECD TG405 m 0 5 Olive oil RYK valli p NAME PIF y pang 05g 1 24 48 72hr ANF C THEKE OECD TG404 m Olive oil RANZ d 0 4 g Hartley REENE y hE RT L Buehler OECD TG406 1 72
70. 0 1 CMC S9 In vitro 300 500 1000 amp 39 URS j S9 Es S9mix 6hr RE SOR ES qp o SOmix MARRE OECD TG473 0 1 CMC REN SOmix 6hr RE d 13 SG CNT in vivo eh Be Ste 39 60 200 mg kg d SN id ign Crlj CD1 CR EE 1 Tween80 as sec OECD TG474 P 24 ELT AADA g CNT 24 lt gt Shvedova 2014 CNT Unidym 40 ng 5 mg m CNT 5 4 pg 1
71. 9000 X g E GE pus ISO TC229 Of OECD qu MSDS Material Safety Data Sheet CNT DNA DNA DNA DNA DNA A 100 41 SG CN TA SC 2
72. KU TASC JHE SWCNT A 1 TASC SG CNT E CNT U AVA 1 SDS 2012 12 TASC 2013 2
73. Qr Qu 1 myday kg Qr Mauderly 0 8L kg 25D 0 8 X 10 x60X 10 X 6hr ASHE 20 29 mday kg Q 1 10 m 70kg LC 10 70 0 14 m7day kg Y DF DF CNT Anjilvel amp Asgharian DF 0 057 DEi 0 118 AMvoLs AMvol Oberdorster Krombach 5D AMvoLs 8 7X10 AMvol 5X 10 um kg body weight 320g 70kg 19 lt 3 BASF fl BASF Nanocyl NC7000 CNT E Nanocyl NC7000 LH E gt JOERA ARTE AER 4 BB Nanocyl NC7000 Hit O ANHEE BC 5 Xue ii NOAELg 0 05 mg m OEL ff 4
74. TASC Dustiness Vortex Shaker 3 ISO TS 12025 TASC ISO TC229 OECD WPMN OECD 2012 12 18 ENV JM MONO 2012 40 34 36 V A A 1 12 TASC 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 2011 CNT
75. 0 MITID OECD TG302C GLP 30 mg L LN 100 mg L 28 BOD DOC 0 2 8G CNT c TERES m DTE Prat P p 2 BOD Af DOC A EE i mgC AD fik GLP gt PM OECD TG301C 28 30 100 0 0 lt GLP gt OECD TG301F 28 100 0 0 30 lt GLP gt mE OECD TG302C 2i 100 3m g id zu c Cyprinus carpio OECD TG305 GLP S 50 ug L REHE 60
76. Medicago sativa 5 g kg dry soil 1 BEC gt 1000 mg kg dry soil 7 SG CNT en fs d pe A H mg kg dry soil id PES B TEQUE I 28 SR TREE E 0D SOTE NA 19900 i NES soil oe OECD TG216 i C OECD TG209 GLP D 100 mg L 2135 Ay ES Ix i1 WH
77. K 9 SG CNT ide E ik CTS HAH 0 2 2 mg kg LDH RIT 0 2 2 0 mg kg 3 PIS fk i 1 io 7 V 3 0 2 2 0 1 3 pee PRS mg kg 2m mago e 3 H3 2 0 mg kg Sy HB l 9 CIECDGSD 0 2 1 mg kg a BALF PAE MME 4 Han LDH IL 1B 6 0 2 1 0 mg kg 3 0 0 04 0 2 p a 1 0 mg kg 6 0 2 1 0 1 6 1 Tween8 mg kg B E Ya Bie Ee 0 PBS d 6
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80. 95405 2011 95406 TASC 2011 A110431 2011 95407 TASC 2011 A110430 TASC 2011 A110432 2011 95404 33 Liou SH Tsou TC Wang SL Li LA Chiang HC Li WE Lin PP Lai CH Lee HL Lin MH Hsu JH Chen CR 34 35 36 Shih TS Liao HY Chung UT 2012 Epidemiological study of health hazards among workers handling engineered nanomaterials J Nanopart Res 14 8 878 892 Kobayashi N Naya M Mizuno K Yamamoto K Ema M Nakanishi J 2011 Pulmonary and systemic responses of highly pure and well dispersed single wall carbon nanotubes after intratracheal instillation in rats Inhal Toxicol 23 13 814 828 Morimoto Y Hirohashi M Kobayashi N Ogami A Horie M Oyabu T Myojo T Hashiba M Mizuguchi Y Kambara T Lee BW Kuroda E Shimada M Wang WN Mizuno K Yamamoto K Fujita K Nakanishi J 2012 Pulmonary toxicity of well dispersed single wall carbon nanotubes after inhalation Nanotoxicology 6 7 766 775 Pietroiusti A Massimiani M Fenoglio I Colonna M Valentini F Palleschi G Camaioni A Magrini A
81. ISO WPMN TASC 2014 6 WPMN READ 2015 2 WPMN MDCK SO TC229 WG3 UH UE NOISE ee ME e p E DOF 7 VO ESTER LOO RHE COT ERES DSTI UC S TASC CNT ISO TC229 JWG2 2012 11 1 OOM BS C
82. MASA 5 Umin o 8MPSC amp 53 gt gt OPC ERR L D a 200 mm E 25 mm 2 wa CNT 5 672500 rpm Op um 9 10 11 27 B S 12 SEM 13
83. 0 08 mg m bie CNT MWCNT QN 44 nm CNT 0 03 mg m CNT lt 2 Baytubes gt CNT Baytubes Baytubes P Baytubes 13 NOAELg 0 1 mg m Adjustment Factor AF Baytubes OELy 1 6 5 0 05 mg m 9
84. 1007 Lm LfD HO 1 CNT ChE CNT CNT NIOSH 30 16 NIOSH CIB 65
85. gt 10 mg L WSR NOEC 0 32 mg L S T 4 SG CNT Loss mg L ECso 72hr 9 E gt 10 AMERRE SR 0 10 0 32 100mgIL 1 mg L Neo d lt GLP gt Pseudokirchneriella 72 1 0 32 10 HCO 40 NOEC OECD TG201 subcapitata e a 0 32 mg L b MFHT A EE Daphnia magna 48 OBCD TG202 GLP 4 3 10 mg L 10 39 ECs gt 10 mg L Daphnia magna 21 OECD TG211 GLP 0 010 1 0 mg L 1 0 mg L 36 6
86. 36 Siracusa G Bergamaschi A Sgambato A Campagnolo L 2011 Low doses of pristine and oxidized single wall carbon nanotubes affect mammalian embryonic development ACS Nano 5 6 4624 4633 37 Fujitani T Ohyama K Hirase A Nishimura T Nakae D Ogata A 2012 Teratogenicity of multi wall carbon nanotube MWCNT in ICR mice J Toxicol Sci 37 1 81 89 38 Roman D Yasmeen A Mireuta M Stiharu I Al Moustafa AE 2013 Significant toxic role for single walled carbon nanotubes during normal embryogenesis Nanomedicine NBM 9 945 950 39 Naya M Kobayashi N Mizuno K Matsumoto K Ema M Nakanishi J 2011 Evaluation of the genotoxic potential of single wall carbon nanotubes by using a battery of in vitro and in vivo genotoxicity assays Regul Toxicol Pharmacol 61 2 192 198 40 Fujita K Fukuda M Endoh S Kato H Maru J Nakamura A Uchino K Shinohara N Obara S Nagano R Horie M Kinugasa S Hashimoto H Kishimoto A 2013 Physical properties of SWCNTs in cell culture and their dispersal due to alveolar epithelial cell response Toxicology Mechanisms and Methods 23 8 598 609 41 Bide RW Armour SJ Yee E 2000 Allometric respiration body mass data for animals to be used for estimates of inhalation toxicity to young adult humans J Appl Toxicol 20 273 290 42 ICRP 1994 Human respiratory tract model for radiological protection In Smith H ed Annals of the ICRP Tarrytown New York International Commission on Radiol
87. 1 0 mg kg THE ITIR BIR KIA ABE Ps EL eS i 3 0 2 mg kg 0 004 02 LDH IL 1B EF 3 0 04 0 2 _ E u DES mg kg nem ems aie D Cr CDSD 1 1 1 3 0 04 mg kg RH HO 5 OATS ssp pagar eB taber EG 0 2 wt mg kg BALF BALF HO 1 anb x Oo WENN lamm RR T mem GRRE 3 i cur inem 2r eo rens MICE MI LRONE Mi OECD TG412 He 5H 7 B cA ox TER ARBRE 1 3 RS WR A p
88. 2011 8 17 NEDO P06041 lt http www aist riss jp assessment gt International Organization for Standardization 2012 Technical Report ISO TR13329 Nanomaterials Preparation of Material Safety Data Sheet MSDS First edition 2009 lt http www env go jp press press php serial 10899 gt Q012 International Organization for Standardization 2014 Technical Specification ISO TS 12901 2 Nanotechnologies Occupational risk management applied to engineered nanomaterials Part 2 Use of the control banding approach Shvedova AA Yanamala N Kisin ER Tkach AV Murray AR Hubbs A Chirila MM Keohavong P Sycheva LP Kagan VE Castranova V 2014 Long term effects of carbon containing engineered nanomaterials and asbestos in the lung one year postexposure comparisons Am J Physiol Lung Cell Mol Physiol 306 2 L170 182 International Agency for Research on Cancer Volume 111 20
89. 8 5 15 0 03 mg m NOAELy NOAELg X NOAEL NOAELR tg ty dayg dayy Qr Qu DFg DFy 5 SAp SA UF tn tu Qr X DFR x dayg SAR eek el ee x m xdayg QuXDFu UF SA H mg m OEL 3 mg m 1 CHA 1 my Qa lk Bide 54 0 3kg 0 189X10 Qy lt ICRP 0 025 1 25L X20 CNT DF DF m
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93. 1 2 3 4 2 1 A AR 2 A a b c B C 3 A oo o Q tn tn tA AHR QR ABA B 14 C MAII I IRR 14 a ee 14 b
94. 1 mg kg Wistar 0 03 0 13 mg m CNT 4 6 S OECD TG412 O VT ORBIT 14 4 NOAEL 0 13 mg m
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97. 2014 1 SO 2009 3 H 0 Ax DEES 2009 2009 7 A 2009 3 E C 3 PEARSE GUA 0 001 0 1 mg m 3 pi As 5 I F C EL TS
98. AM N A KE NIOSH CNT NIOSH 5040 E CO CH4 FID CNT CNT IARR RE OEL CNT
99. portable black carbon monitors and photometers for measuring airborne carbon nanotubes J Nanopart Res 15 2033 Ogura I Kotake M Hashimoto N Gotoh K Kishimoto A 2013 Release characteristics of single wall carbon nanotubes during manufacturing and handling J Phys Conf Ser 429 012057 Ogura I Kotake M Shigeta M Uejima M Saito K Hashimoto N Kishimoto A 2013 Potential release of carbon nanotubes from their composites during grinding J Phys Conf Ser 429 012049 NIOSH 2012 General Safe Practices for Working with Engineered Nanomaterials in Research Laboratories DHHS NIOSH Publication No 2012 147 May 2012 NIOSH 2013 Current Strategies for Engineering Controls in Nanomaterial Production and Downstream Handling Processes DHHS NIOSH Publication No 2014 102 Nov 2013 TASC 2013 NEDO P10024 lt http www aist riss jp assessment gt Horie M Stowe M Tabei M Kato H Nakamura A Endoh S Morimoto Y Fujita K 2013 Dispersant affects the cellul
100. 012 12 28 2 2014 6 H 30 H 3 20154 3 27 CN T TAS C T 305 8565 1 1 1 5 T 305 8569 16 1 SG CNT lt gt Email tasc3 ml aist go jp NEDO
101. 12901 2 E D gt SBE SI SRNL KDOR FKF EB 1 2 E CB 3 CB 4 10 as tft EP Ax XE BAY FP 4 Y ZECO REM IEM ROA FIIV CHORD RRN F HBC 0 01 0 1 mg m EB 4 EB 2 3 3 T nul M
102. 14 Fluoro edenite silicon carbide fibres and whiskers and single walled and multi walled carbon nanotubes IARC Working Group Lyon 30 Sep 7 Oct 2014 IARC Monogr Eval Carcinog Risk Chem Hum in press Yann G Dana L Kathryn ZG B atrice L S Fatiha El G V ronique B Lamia B T Neela G Chiara S Heidi M Kurt S 2014 Carcinogenicity of fluoro edenite silicon carbide fibres and whiskers and carbon nanotubes The Lancet Oncology 15 13 1427 1428 Donaldson K Murphy FA Duffin R Poland CA 2010 Asbestos carbon nanotubes and the pleural mesothelium a review of the hypothesis regarding the role of long fibre retention in the parietal pleura inflammation and mesothelioma Part Fibre Toxicol 7 5 Murphy FA Poland CA Duffin R Al Jamal KT Ali Boucetta H Nunes A Byrne F Prina Mello A Volkov Y Li S Mather SJ Bianco A Prato M Macnee W Wallace WA Kostarelos K Donaldson K 2011 Length dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura Am J Pathol 178 6 2587 2600 Nagai H Okazaki Y Chew SH Misawa N Yamashita Y Akatsuka S Ishihara T Yamashita K Yoshikawa Y Yasui H Jiang L Ohara H Takahashi T Ichihara G Kostarelos K Miyata Y Shinohara H Toyokuni S 2011 Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis Proc Natl Acad Sci U S A 108 49 E1330 13
103. 38 Nagai H Toyokuni S 2012 Differences and similarities between carbon nanotubes and asbestos fibers during mesothelial carcinogenesis Shedding light on fiber entry mechanism Cancer Sci 103 8 1378 1390 Finnish Institute of Occupational Health 2013 Evaluation of the health effects of carbon nanotubes lt http www tsr fi c document_library get_file folderld 13109 amp name DLFE 9367 pdf gt Matsumoto M Serizawa H Sunaga M Kato H Takahashi M Hirata Koizumi M Ono A Kamata E Hirose A 2012 No toxicological effects on acute and repeated oral gavage doses of single wall or multi wall carbon nanotube in rats J Toxicol Sci 37 3 463 474 Ema M Matsuda A Kobayashi N Naya M Nakanishi J 2011 Evaluation of dermal and eye irritation and 35 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 skin sensitization due to carbon nanotubes Regul Toxicol Pharmacol 61 3 276 281 Hata K Futaba DN Mizuno K Namai T Yumura M Iijima S 2004 Water Assisted Highly Efficient Synthesis of Impurity Free Single Walled Carbon Nanotubes Science 306 5700 1362 1364 Nagai H Okazaki Y Chew SH Misawa N Yamashita Y Akatsuka S Ishihara T Yamashita K Yoshikawa Y Yasui H Jiang L Ohara H Takahashi T Ichihara G Kostarelos K Miyata Y Shinohara H Toyokuniet S 2011 Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis Pr
104. APS Aerodynamic Particle Sizer BALF Bronchoalveolar Lavage Fluid BCF Bioconcentration Factor BET Brunauer Emmett Teller Theory BMCL Benchmark dose lower confidence limit BMD NOAEL BMD Benchmark dose BOD Biochemical Oxygen Demand BSA Bovine serum albumin BW Body Weight CAS No Chemical Abstracts Service Number CB Control Band HB EB CIB Current Intelligence Bulletin CMC Carboxymethylcellulose CNF Carbon Nanofiber CNT Carbon Nanotube CPC Condensation Particle Counter CVD Chemical Vapor De
105. CNT o SWCNT uo SWCNT E CNT MWCNT 7 ICR E CNT Sigma Aldrich c 80 BRE PEIRIRIC BITS f OECD TG471 in vitro OECD TG473 OECD TG474 12 SG CNT in vitro TA97 TA98 12 5 25 50 100 TA100 TA1535 S9 200 500 uug plate S9 OECD TG471 WP2uvrA pkM101
106. O VY EB4 CB 4 EE CAW 2014 10 ARC cp Na 1 4 CNT MWNT 7 MOT MEE uM c E 2B 2 CNT CNT ME
107. OECD TG204 GLP 0 10 10 mg LCso gt 10 mg L NOEC 10 mg L X 6 SG CNT A i is i GmgL 2405 29 5 Han 5 lt GLP gt i 100 mg L LCso og ie OECD TG203 Oryzias latipes HCO 40 mg L LC 50 14d 10 lt a stats 14 0 10 0 32 100mgL mg L gt KM OECD TG204 Oryzias latipes 4 1 0 3 2 10 Tween 80 n d is mg B 28 OECD TG216 GLP 1000 mg kg dry soil
108. OSH 2 5 General Safe Practices for Working with Engineered Nanomaterials in Research Laboratories 7 2012 5 Current Strategies for Engineering Controls in Nanomaterial Production and Downstream Handling Processes 2013 11 H CNT m 15 IS T 8150 2006 2
109. ar influences of single wall carbon nanotube the role of CNT as carrier of dispersants Toxicol Mech Methods 23 5 315 322 Fujita K Fukuda M Endoh S Kato H Maru J Nakamura A Uchino K Shinohara N Obara S Nagano R Horie M Kinugasa S Hashimoto H Kishimoto A 2013 Physical properties of single wall carbon nanotubes in cell culture and their dispersal due to alveolar epithelial cell response Toxicol Mech Methods 23 8 598 609 SPICE 2013 International Organization for Standardization 2012 Technical Specification ISO TS 12025 Nanomaterials Quantification of nano object release from powders by generation of aerosols First edition 38 ADME Absorption Distribution Metabolism amp Excretion
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