適切なOn-line HDF/HF療法を目指して
Contents
1.2. CMPF 7 p 7 International Urology and Nephrology 20 13 45 139 15051 RERMROHR EEEF HF COTMEHA ISLA O ES I HF 7 on lineHF PS 1 9UW Fresenius Kawasumi Co 250 HDF HDF 00 500ml min QF 80ml min HD QD 500ml HD Pre HF QF 300ml min 200 Post HF 80ml min 150 Pre OHF 2 4241 00 Post HF 50 0 10 100 1000 10000 100000 HF On Line At ROOn LineHF Ta 7 Ici CP E 300ml min AS Yez u 1 P1ERTK gt N lt gt Cp 400ml mint PTER2K 100ml min lt 400 N 7 27 27 HF ORRA
3. 3 0 lt 3 5 3 5 lt 4 0 40 lt 45 4 5 g dL 20095128131 7 Da B B2 B6 C B12 ERS E T t 100 200Da TILZS gt 64000 t 100 200Da ZMG 11818 DRA C 13000 8000 30000 IL 1b IL 6 TNF AGEs DRA CFU E 7 7 RE 16000 factorD FGF 23 32000 Y 4254 7 1750 a IMG 33000 gt
4. 77 e P K EMSS CIC ATG Che OC TIE SN EBE HAREM ih ROT AQ MIA PEN RAS 7 7 _ AGES BHEETIL2S7T gt PEER AT BORE da zs DOPPS ert COE TIT mal iL C 12 K V VA Ca PTH etc FEI MET s gt 125118 386585557 Z 197ml
5. BUS Gx Bo Salahudeen AK Nephrol Dial Transplant 18 1339 44 2003 MAAK retrospective BAW 5 9m K V gt 1 68 2 RBKENB toxic effects of rapid and vigorous dialysis fe VIS RBI 1 4 9 77 2 n as 7 L0SS IE f LARARE 7 HD4 n 68 152 MIE 728 EEN 5 dL F LAETOLI EE OSH EID 2 5 47 KT V 184006 P 56 88 7 24 n 70 4 mhi 150 250 1571117723 6711127 BAS 3 5mEq LA HR 52662095 3 1 3 5 43 2 0 3 0 17
6. EA rr ar P AUI 448 75 0 23 0 6 0 mg L EAE mg HD HD HD HD HD m9 67 495 244 4459 1636 2823 8268 67 395 178 3 554 1 195 2359 6524 67 101 66 905 442 464 174 1 61 38 25 339 169 170 80 58 T xA IT cl Thr LYS 7 RE 7 CAL 7 Ry IATE 11 126 30 TILAS g dL 7 95 30 3 305 3120 3503 0001 3 0 lt 3 5 1110 1 690 1 854 lt 0001 35 lt 4 0 1 000 XJ BR 40 lt 4 5 0 717 0669 0769 0001 45 0 731 0 574 0 929 0 0104 1 426 1 317 1 545 lt 0001 1 770 2008 3 2008 2 159 659 2009
7. 77 BUN 77 UN Cre P 82 M6 a 1 MG Skewers WBC PLT pH Lacttate HCO3 2 5h 2 QB 250mL QD 500mL 5h Mite 0 250 min 87522 05 300mL min 56 HD 02 STAT mean SD paired t test 0 05 ml min 250 200 150 100 20 UN Cre P 2 e MG paired t test 005 4001 0001 2 100 90 80 70 va D o UN Cre 2 MG paired t test 005 4001 0001 25 000 20 000 15 000 10 000 0 260020022 E paired t test 0 05 001 0001 1 7 7 Cre ZMG paired t test 0 05 001 0 001 300 0 250 0 200 0 150 0 100 0 20 0 0 0
8. J PSR ta 3 MFX ABH P 1 1 1 5 1 9 2 1 2 5m lt TDF M 6GDF 13 15 18 2 m2 py mi Ho 10 13 1 5 1 7 20m 15 18 2 1m UFR67 mL mmHg hr MFX S UFRAG 0 mL mmHg hr 1 1 1 5 1 9 2 1 2 5m TDF H ABH F UFR67 mL mmHg hr 10 13 15 17 2 0m 1 3 1 5 1 8 2 1m 15 1 3 UFR mL mmHg hr UFR60 mL mmHg hr 15 1 9 2 1 25m mL mmHg hr HDF 7 142 136 HDF BMGC 2 7 02 1 784 AF 7 BMG AMG amp COIBSBEIG 5 Alba 1M6 c 1 R23 rh eje HDF tL rh ze 5 1 PHAR ED RT OLD ya SOS w Ni fie 2 nes p ESEN s ze ABI Im 23 gs 439 ey E 3 ART Bi 177 PHAR EE 26 90 80 10 60 20 40 30 20 10 HDF 10 E QF200 ABH 2IP i m QF 300 400 1 E 6 5 4 3 2 1 0 UN B 2MG a 1MG
9. 9 1 9 23 Y 30 HD lt lt PEEP VON e lt 200955 20105 20115 e 20123 AV aS WN ve N ike HDF HDF HF HDF EX HRA iz BIRKS A HDF AFBF 2010s O p p HDF L on line HDF off line HDF on line HDF 6 852 4 829 4 890 14 07 86 20 5 6 zl HDF 96 14 867 14 115 100 0 100 0 HD HDF 270 660 277 840 284 187 289 049 2009 2010 2011 2012 CR TI 1 d 4 4 d 1 612 7 160 4 4 86 d Ty o 2 a 1 L irc 471 197 1238 E 7 6 16 100 0 70 HDF 011 5 3 50 40 30 20 off line HDF omine HDF HDF 450 2012 2 3 one 1 2 Online fe mits O KEICeOB Makes RAFE REPE Restless legs syndrome EDTA best practi
10. V 1 519 2 22 14 9 SPP mmHg 3H 4H 6 7 8 9 12 2O HEU 1 1 1 1 2 2063587 292478 2925114 78 5 14 3 1 1 3 PR 176152 263482 343131 79 5417 8 ed Boa SAIC SEO SPP SPP lt 0 01 Tukey HSD p lt 0 01 Tukey HSD ERAF 2011 3 47 51518 u mol l 77 _ 500 400 300 2004 _ ZZmg L 100 aV 2 a 4 77 M e e gt K 4 2 7 n 8 HD n 6 xP gt 0 05 AL 4 lt l 32 2 K RY RZ 4 VOL 83 No 1993 12 mTOR 1 wa rpS6 elF4E x mRNA
11. 2013 10 31 XS 1 Cl c f 7 7 MOET ENS NUR 5 1 7 19 A 4 Bas Ws a x 27 SB A E pt Ez F F2ETECIS 20 866 0 3 4103332581868 2 0 3 0303 9 7 0 6 0 10000 0000 0 0 0 0 0000 0 1 0 1 ZU 2228 35 40 do 50 65 4 Ape qug 85 90 95 38 71 8 2012 72 31 OE 1 1 RAMEE BIN S CHEN 001 RIS FTN gt 1 d 1 I 1 1 D p s 1 N b L i T 1 b 1 B oi S A B 1 2 EN 1 1 w m _ a 1 4 Ww ka AN I E 1 2e m L j 22 e FRE TAE CE Linea LH e 19 e Bii A CIC
12. w 100 mmHg Aigo 200 mmHg 300 mmHg 2 13 4 2 6mm 0 4 1 100 1 Mulholland JW Massey W Shelton JC Investigation and quantification of the blood caused by the combined dynamic forces experienced during cardiopulmonary bypass Perfusion 2000 Nov 15 6 485 94 2 Toomasian JM McCarthy JP Total extrathoracic cardiopulmonary support with Kinetic assisted venous drainage experienc in 50 patients Perfusion 1998 Mar 13 2 137 43 HD027 amp l 4f P ml min 156 3 mmHg ml min 200 29 w as 78 87 6 85 87 6 87 10 88 50 54 168 6 166 8 165 0 106 118 118 250 110 113 116 sa sa 204 6 201 6 201 0 166 4 38 41 53 i u s 87 0 105 84 6 115 852 122 840 138 100 110 111 130 162 0 161 4 160 2 159 0 151 156 162 176 135 148 148 162 196 8 192 6 190 2 187 2 seis nin RE 17G 4 min 156 3 62 71 72 88 135 150
13. OHF HD 1 paired t test 0 05 0 01 0001 3 500 3 000 2 500 OHF HD 2 000 1 500 1 000 500 Alb paired t test 0 05 001 0001 2 RISR 100 gt w 80 vs Group 1 4 60 lt 0 05 p lt 0 01 o 40 coss lt 0 Group 3 Group 1 Group 2 Group1 2 M 759 6 o M 209 6 Group2 2 M 759 6 o i M 209 6 Group3 2 M 759 6 o M 2096 1996 OHF ticle amp 5611834 21 1083 21813 115 2009323 45 HD QB150ml min QD500ml min 2009 928 45 OHDF QBZ200ml min QD600ml min 36L CaxIP 2009 11 27 50 0HDF QBZ00ml min QD600ml min 40L 4 iM 5 08 230 250 QGD400ml min 90L DC6G 03 60 My 1 27 HORRET i A F F Tin
14. 151 185 Lo s L 2316 234 6 234 6 2274 84 0 164 84 0 187 84 0 199 84 0 210 201 203 231 153 0 150 6 150 0 141 6 m xc m 211 237 245 259 gt 4 3 m Sas sess 180 6 174 6 174 0 165 0 330 0 319 2 313 2 292 166 4 194 204 220 253 I zc 219 0 2 216 0 259 213 0 2 200 4 237 239 269 m E Lu sess 288 0 2832 2712 240 0 176 4 270 287 294 zc mc s 178 2 192 6 190 2 213 m ba ba ba GA Ln 4 LE 220 2 2256 2040 m 200mi min 170 1 5mm 2Z40ml min 166 1 7mm 240 156 1 9mm 280mi min 156 1 9mm 42 128 2 m3 S Pa S 4 m AP Pa SCI HDF HDF HF pe ities HDF
15. 487ml 4 4 7 63m2 5 4 5 DW lt QO 53 8Kg gt 01 320085 1283 1 191591 Shinzato T Survival in long term haemodialysis patients results from the annual survey of the Japanese Society for Dialysis Therapy Nephrol Dial Transplant 12 884 8 1997 RR mortality 15271 retrospective BBY 71746 RRIS 1 K V 1 0 1 2 JSDT single pool 4 Kf V K V 1 8 2 0 9 Held PJ Kidney Inf 50 550 6 1996 GAA retrospective 23 1 1 5 2 4 K V 0 1 7 URR 5 1 1 Kt V gt 1 3 URR gt 70 1 Se AB eS BIST Ge Chertow GM Kidney Int 56 1872 8 1999 GAA retrospective 3009 18m URR gt 71 0 RR KEST EEE 1
16. EU mL 450 20017 211 15 3 0 761 11 77 Siri Mines CC 56918 1 062 028 1 035 0 96 0 98 0 94 1 096 11 0 92 0 1 1 10 100 cfu mL 2006 1 CC 99 Right 2nd to 4th fingers stamped on SCDLP 48hrs cultured in 35C incubator Aeromonas sp Corynebacterium Acinetobacter sp 34 sp 5 Enterobacter Es RE J 7 RS cloacae 1 8 E 4 Enterobacter sp 1 7 Klebsiella oxyt 37 E Klebsiella 1 oneumoniae 1 XBEZL 45 Micrococcus sp Pseudomonas 1 aeruginosa9 pu Serratia Pseudomonas sp a marcescens 17 244 2007 154 Pseudomonas aeruginosa 5 Corynebacterium sp 1 Micrococcus sp 1 Burkholderia Pseudomonas 50 7 79 Sphingomonas ERA paucimobilis i 7 7 2009 124 71 Fh 1 2 SCI HDF HDF HF 2 99 1 22702 85
17. REE s0F200 48L 250 601 10 1 ogQF300 72L MEX 21U orao0 960 7 6 5 4 2 1 0 2MG 1 6 QB 250ml min 00 500 min Qs ALB Fr ALB 4 N 5 7 ABH 21P 0B 250ml min mL 00 500 n 5 Qp 350 mmHg 200 7 4Hr 150 5g TMP 27550095 3 19 4213 55 Eia 88 EE KERREIZH SCI HDF HDF HF gt VA 0 ETHEL C dil rim rm cg Ac
18. FF TO TEU Fa Tim ET GOI EEE FEF beet ee ERTE ZIEL Tet se E ROURKE EEE AE AAE RELL TREE HORE EEE z BS5EDRLTENHZIEETZA lh FEE TE FEF Bir FN 28 eram Ig ges RT LA ER gt TIEN HGT C H ENS i FEA ees Me I TOHA E ARR ee Topor Cri 4 REET Ed tee eh gt 4 2 Li I LT A EEFE Uo Fe TEFL HT TH IE lt mo EE LA SE gt EN Aft GZ NELER m FOF ET Tel FI DER grand wA eS ii TI qr LE L m LOEO raci n E N PRE LEG Fl 4 1 2477 7HFO RisK L xL n S 0 05 lt 0 0001 0 0001 001 005 01 025 amp gt mL ET 0 100
19. ce guidelines BR On line HDF HF PCEN A RIK RER QB lt 0S AK S 1 1 2 1 3 BETTE S ET KES Letter BAEC aL Ran HUTE RIF re ENR ICFUARL ZM ETE NDT 115 7 4 1 Toit E L T SF E E p z PCAS 2008 dE ddl 1 12 71 Mo Lath Ed EEIT e dii Ae LCE DRE REF 2003 ele EEE L KEEREEZEZISEGS LEV PEN EF G1 ae FET hh m uw EF DtnDskOTEPREEBEEBR 7 Er DTEIEB4EXE U ENER m 1 D CTUU LE 1 gt FACE te
20. e gt BEF FTE eo TE HECE L LIEITENECL 1 Fs gdTwiU WE lt i 4 ir mirim LET kh 7 54 Z EZE GF HH Z E ETAF i ide DARE eS BUC LIS UT S 34111113 Z Eee 00 22 ine dnd araf Dub Hron bear parke 1242 da of Medial ra WU ES SERRE Fee pew gt U EDEL TM ni SE 77727 gt gt 5 fini EL Ihi ECO PLATA BHL EEN EIN Le be Tdi TABERI NELT E ET OL 280 EF EH RERE dau Stat Cl MAANTEE L Lo TI S gt ET D ONE DH erara Orgad the SursunSmcen ttre fei TI wes ES LERF EER BEH SL TE ECE PROE Eu L EET AT EERE iF WE WE prepared abari TE es 5 CE 6 2 LOIRE TER EU E
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