No.342 2013年6月
Contents
1. RS SR S2. Toxic Epidermal Necrolysis TE IN Stevens Johnson CT S42 4 Toxic Epidermal Necrol
3. 4 5 1 1 1500mg 4 2
4. 1 2 N N I N N ee ee ORK
5. Toxic Epidermal Necrolysis TEN Stevens Johnson A i
6. NN CO 342 1 EO RE 3 PMDA PMDA No 38 http www info pmda go jp anzen_pmda file iryo_anzen38 pdf PMDA http www info pmda go jp anzen_pmda iryo_anzen htm1 2 1 2
7. S42 12 gp
8. ADEM ADEM 2 MRI 2 250mg 12 CRP
9. 1 2 14 3 5 10
10. 1 amp 180mL 30 3 2 1 108 206 18 6 A 35 3 2 27 2 4 22 2 0 15 1 4 1 A A amp A Ck
11. CRP EN F A A A A A A A A A A A A A A A 2 A A A A A A A A A A A A gt 3 Drug Safety Update No 219 2013 5 NAY EE 2 GE EE GE GE 2 A A A GE A A A 2
12. 7 17 DSM IV DSM IV American Psychiatric Association Diag nostic and Statistical Manual of Montal Disor 4th edition DSM IV X CT gt
13. 1 100mg 1 3 2Z 5mg 5mg 2 5mwi 10 20 5mm 166 00 5mg 1 1 2 5mg 1 1 5mg 1 5mg 1 2 S42 6 1 40mg 1
14. 5 ee 6 Stevens Johnson 1mg 1 2 30 3 4 5
15. 60mg 6 1 RI 20m9 9 52mg m2 1 1 2 5 9 1 1 C20 9 CD20 342 7 1 300mg 2 2000mg 8 8 4 5 4 1 1 20
16. gl 4 0 6 7 8 342 9 14 2 3 599 486 81 1 248 41 4 15
17. 4 3 gt EC 3 7 3 HI 252
18. 1 1 1 4 4 1 2 1 8 1 2 4 1 2 1 8 1 4 2 RN 0 lt
19. 3 7 Toxic Epidermal Necrolysis TE IN Stevens Johnson X CT
20. 165 50 0 68 20 6 50 15 2 42 12 7 MS 41 12 4 o 1 2 0 3 4 AST GOT ALT GPT
21. AST GOT ALT GPT GTP ar 10 1 J Ne E15mg 1 I 1 24 I 3S42 10 2 7 17 18
22. ec 20m g 1 1 40mg 1 1 333mg _ 333mgl 50 10 EE 666mg 1 3 7 1 00mg 1 CA 100mg1 36 20
23. 1 2 1mg 1 1 180 mL 30 S42 11 1 Ca Mg 30 2
24. a 3 Toxic Epidermal Necrolysis TE N Stevens Johnson 2 oo 4 2013 5 24 Lennox Gastaut Lennox Gastaut 4 15 0 30 0kg 2 1 200mg 1
25. H 330mg ASK S42 13
26. S42 5 2 2 1 200mg 1 1000mg 1 2 1 1000mg 2 1 200mg 1kg 2 1 400mg 1 2 2 1 400mg 30 1 50 0kg 1 1800mg 50 1 70 0kg 1 2400mg 70 1kg 1 3200mg 1 2 2 1 400mg 7 20mo FTEG7T
27. 1 2 313 4mg 1 2 2 403 895 37 25 14 23 11 15 7 78 5 29 9 3 29 2 25 1 83 1 79 1 12 O 1 0 08 2 S42 8 0 25 0 17 0 lt
28. 1 15mg 15 30mg 1 1 1 45mg 1 1 15mg 8 MAO MAO 2 MAO 2 330 273 82 7 914
29. Drug Information News i 1 3 6 l 74 TEL 0834 31 7716 a FAX 0834 32 5349 gt e mail yaku tokuyamaishikai com 7 http www tokuyamaishikai com yaku index htm 1 0 5mg 1mg 5mg 1 K2 K2 K K 2
30. Diag nostic and Statistical Manual of Mental Disorde rs 4th edition DSM IV MeijiSeika 18 18 18 DSM IV 7 17 18
31. 1 160mg 3 1 1 lt 1 25mg a 0 04mg kg 18 0 06mg kg 1 8 0 08mg kg 1 1 0 02mg kg 0 03mg kg 0 04mg kg 1 696500mL1 970 1 50 mL kg 60mg
32. GE 2 2 2 A A A A 6 17 18 342 2 6 17 DSM IV 1 1 2 189 1 1 2 184 1 6 3 189 DSM IV American Psychiatric Association
33. N 2 No 301 2013 5 2 2
34. 00mg 12 A 3mg kg 1 1 4 1 250mg MA A A A A A A A A A A 2 2 2 1 5 156 7nmg 156 7mg 389 8 Mat EE 15mg 15mg 167 5 22 0 PT EPR 1mg lmg 132 7 156 7mg 1 2 3 4 5
35. 7 26 2 155 25 9 127 21 2 113 18 9 1 i 0 2 0 2 I A NE RS RE a
36. ysis TE IN Stevens Johnson ce Toxic Epiderma Necrolysis TE N Stevens Johnson i Pe
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