2013年11月版（pdfファイル形式）
Contents
1. HbA1c NGSP 7 0 JDS 6 6 90 6172. 116
3. asterixis
4. 5 1 0 60 40 20 0 0 0 1 SABA 8 LABA 8 LAM
5. 9 Toxic Epidermal Necrolysis TEN Stevens Johnson Ei No 224
6. PT 1 2
7. 1 1 EE 0 No 223 0 a
8. CK CPK 7 113 2
9. 23 ae a p 4 2013 7 21 9 20 HH ES CGaroon gt gt gt 5 2013 11
10. 1 2 1 2 CYPE3A4
11. P P P P ACE ACE
12. 19 Ardouin C et al Mov Disord 2006 21 1941 1946 Cilia R et al Brain Struct Funct 2011 216 289 299 Dodd M L et al Arch Neurol 2005 62 1377 1381 Mamikonyan E et al Mov Disord 2008 283 75 80 Pontone G et al Neurology 2006 67 1258 1261 Singh A et al J Clin Neurosci 2007 14 1178 1181 tamey W et al Neurologist 8008 14 89 99 Voon V et al Neurology 2006 67 1254 1257 Vaon V et al BMC Neurol 2011 11 117 Weintraub D et al Arch Neurol 2006 03 9069 973 Weintrau
13. HES 90 ICU HES 90 ak wee No 224 11 118 ERAN Eh
14. 1 2 te hire rw
15. HES 90 ICU HES 90 HES ETUUUOUTEEUPTOEE22EEREEOO is G15
16. X CT a Toxic Epidermal EN TEN Stevens Johnson 3 RE ie lt 1 1 7 QT QT
17. 1 1 2 3 30 50 R
18. MI 8 89 2 8C 2 1 1 5mg
19. 1 2 18 Toxic Epidermal Necrolysis TEN
20. 2 3 3mg 1 65mg 8 25 R 11 1 1 2 3 4 2 14
21. QT1 E rsades de pointes de MSD 214 a 3 3831 70000 0000 HES
22. 12 a
23. 5 6 FF 2 1
24. 50kg 1 6mg kg 50kg 1 300mg 22 NP MSD 631
25. 1 88mg 3 75mg 49 331 7 70000 70 000 13
26. 100mg 1 13 MAO B Tpxic Enidermal Necrolysis TEN Steyens Johnson
27. Toxic Epi Stevens Johnson 113 17 2
28. 212 R 17 EE 7 9
29. Garoon gt gt gt 4 24
30. 6382 1 1 29 2 2 27 6
31. 1 a 1 16 2
32. 2 QOL 500 10zg 7 18g a ea 60 100 LABA LABA SABA a es 1 1 1 2 1 4 1 2 1 12 COPD 1 2 1 2 Ie E ij i
33. 8 w
34. P ACE ACE P 2 0 42UPC LV ACE
35. 15 CK 0 3 4
36. Stevens Johnsan Toxic Epidermal Necrolysis TEN Stevens Johnsan 10 20
37. by 3 ND a 2L 5 MSD 1 13 12 2 1
38. C ET 1QT QT QT torsades de pointes 4 11 BUN 11 OD A 119 pr
39. zs46 1 4 30 1 1 1 1 65 8 3mg 3 3mg 1 65mg d 1 5mg 1 1 d
40. 10 116 Ardouin C et al Mov Disord 2006 21 1941 1946 Cilia R et mal Brain Struct Funct 2011 216 289 299 Dodd M L et al Arch Neurol 2005 62 1377 1381 Mamikonyan E et al Mov Disord 2008 283 75 80 Pontone G et al Neurology 2006 67 1258 1261 Singh A et al J Clin Neurosci 2007 14 1178 1181 atameY W et al Neurologist 2008 14 89 99 Voon V et al Neurology 2006 67 1254 1257 Voon V et al BMC Neurol 2011 11 117 Weintraub D et al Arch Neurol 2006 063 9069 973 Weintraub D et al Arch Neurol 2010 67 589 595
41. PDE5 2 rw 5 a gt 14 RE Toxic Epidermal Necrolysis TEN Stevems Johnson
42. 45 90 4 a 21 1 45 1 2 7
43. 124 9 4 3 lt S 18 339 AST GOT ALT GPT Al P Y GTP LDH AST GOT ALT GPT Al P Y GTP LDH
44. 1 2 2 2 3 4 1 Bssal Basa Bolus Basa 2 BasaLBolus 1 2 Basa
45. S S18 339 CK CPK 0 10mg 0 S32
46. gt pi 2012 9 1 1 2 1 1 1 4 20 1 4 80 1
47. 3 _ DSU _No223 224 Drug Safety Update DSU 3 DI DSU Http www info pmda gojp gt gt DSU 92OZEIIEEBD2 2 ON URL http www info pmda go jpD dSu dsu index html es Sa EIY POANS 103 0023 2 1 5 FAX 03 5201 3590 No 223 114
48. d IE 1 2 3 4 A 1 5m 1 1 6 hi
49. A 8 ACE
50. Yokohama Stroke and Brain Centery Vo 14No 4 85 2014 11 DI 1 Hsee 1 1 65mg 5mg 2 3 3mg 8 25 RE 2 io 1 2 3 3 DSU No223 im 4 2018 7 21 9 20 24 5 2013 11 24 ITTTTTTT TT TT TTTTTTTTT TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTYTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TT TT 1 1 1 1 4 20
51. b D et al Arch Neurol 2010 067 589 595 0E 7 14 HIV HIV 20
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