Immersion Cell (with Small Volume Vessel) User Guide
Contents
1. cee eccccccesseceesseeeesssecesseeeesseeessseeeeseeeess 6 2 5 1 FOr Se Wina vV on ENG 8 TESTE enon E eee 7 2 5 2 For Use with a Vision Classic 6 T Stel cecsscccssssscssssecsssecsssseecssseesessseesssasesssssecesseeesssaseseeas 8 2 9 3 For Use with an SR8 PIUS TeSter cceccssccsssssccesssecssssecessssecssseeesssasessssssessseeesssesesssasesssneeess 9 2 CCC SSO DUO INS anaE EE ae senesuee avnecuaesenasundatsyoneedoneetusatescuaesenncuadetonots 11 de 92101 672 0 eee ee ee ee ee E eee ee ene ee eo eee eee AA 12 2012 Hanson Research Corp 65 190 027 Rev C Page 2 of 13 Immersion Cell User Guide 1 Introduction 1 Introduction 1 1 The Immersion Cell Hanson s Immersion Cell p n 65 190 043 with the small volume dissolution accessories in conjunction with the SR8 Plus or Vision dissolution testers is a test system designed for ointments creams lotions etc for quality control purposes The system uses a standard SR8 Plus or Vision type dissolution test system The test is the same as standard dissolution testing with the exception of using a small mini paddle and vessel with the immersion cell inside the vessel The testing agent is not a tablet but an ointment The ointment is sealed in a delivery chamber where it can only move into the solution through a membrane 1 1 1 Immersion Cell Features Membrane Area Dosage Area 1 1 2 Immersion Cell Options 65 190 043 Immersion Ce2. Wetted Materials Teflon borosilicate glass Viton Size Orifice Area 15 mm Dosage Area 3 mm deep x 15 mm diameter Membrane not included 25 mm diameter Ointment Capacity 0 53 mL Small Volume Vessel Wetted Materials Borosilicate glass Vessel Capacity 150 mL 2012 Hanson Research Corp 65 190 027 Rev C Page 12 of 13 Immersion Cell User Guide 5 General Warranty Hanson Research HRC products are warranted for one full year including parts and labor Service contracts and Preventive Maintenance contracts are available for post warranty support International dealer warranties may vary HRC makes no warranty expressed or implied for glassware consumables or products not manufactured by HRC as evidenced by nameplate on the item or other designation HRC will give responsible assistance to buyer in obtaining from the respective manufacturer whatever adjustment is reasonable in light of manufacturer s own warranty HRC shall be released from any and all obligations under any warranty either expressed or implied if the product covered is repaired or modified by other than its own personnel or made without written authorization from HRC There are no other warranties expressed or implied and HRC shall not be liable under any circumstances for consequential damages Page 13 of 13 65 190 027 Rev C 2012 Hanson Research Corp
3. oo ISION S Immersion Cell with Small Volume Vessel User Guide 65 190 027 Rev C Immersion Cell User Guide Sales amp Support Congratulations on the purchase of your Hanson Immersion Cell s While we are certain you will enjoy the Hanson experience we also understand that from time to time you may have a question or technical issue requiring our assistance Please feel free to contact us at any time We re happy to help Online www hansonresearch com Tech Support Request Form www hansonresearch com tsr E Mail techsupport hansonresearch com Phone 800 821 8165 or 818 882 7266 Fax 818 882 9470 Corporate Headquarters Hanson Research Corporation 9810 Variel Avenue Chatsworth CA 91311 USA Page 1 of 13 65 190 027 Rev C 2012 Hanson Research Corp Immersion Cell User Guide Table of Contents Mig WENO OIG OI orea e E A EE A E E E E E 3 Het TAS TIVE SI OTs A E A A E E E E E 5 1 1 1 MOSON CEI FE UE ri a E A E E EE E E E E ENEE 3 1 1 2 MmMmersion Cell COINS riserciseesion akepe neei EE EE A AAEE EAEEREN 3 1153 PITS SION SU TOOS aca ones secv rs cect TE 4 2s WISN AON a E E 5 A GONDO a EE E EEA N EAEE E 6 22 WAIST SION Cel ASSEMDV sesers ara E a dex denies AEREE 6 23 Immersion Cell Installation cccasa cectsncteeseceniecaced snares snstestueesseenecertescuesoteceacaoserceanesesnaseuneeeuos ebacnnteeteanesece 6 24 imne on CE RENOV a r A EE TE E 6 2 5 Installing the Immersion Cell in a Dissolution Tester
4. Unscrew rod and remove after placement 8 Lower the drive head to the lowest position The spin paddles should be about 10 mm above the immersion cell 9 Install a vessel cover over each vessel and start test Note The small volume accessories were not designed for use with the AutoMag The AutoMag if it is present must be removed before installing small volume vessels on the Elite 8 Clamp Knob Easi Lock Vessel Cover Adapter Ring Flat Bottom Mini Spin Vessel Paddle Immersion Cell Assembly Fig 6 Vision Configuration 2012 Hanson Research Corp 65 190 027 Rev C Page 8 of 13 Immersion Cell User Guide 2 installation 2 5 2 For Use with a Vision Classic 6 Tester Page 9 of 13 1 Raise the spindle shaft to about 1 below the fixed drive head removing any basket shafts or paddles already in place Install the Easi Lock Adapter Ring for Small Volume Vessel into the hole where the 1L vessel would normally mount and turn clockwise to lock into place Carefully insert the small volume vessel into the adapter ring and secure in place with the clamp knobs Repeat steps 2 3 for each small volume vessel used Fill each vessel with desired media volume cover the vessels and allow the bath and media to reach desired operating temperature Install mini spin paddles by screwing into spindle shafts tighten securely Assemble all immersion cells remove covers and place each into a vessel using the installation
5. arger opening face up Place support ring on support tool Place orifice washer on support tool it should rest on the top part of the post Place membrane in orifice washer ee Page 5 of 13 65 190 027 Rev C 2012 Hanson Research Corp Immersion Cell User Guide 2 installation 5 Place ointment washer on top of the orifice washer the two should fit together to hold the membrane in place Squeeze these together making sure to keep membrane wrinkles to a minimum 6 Apply dose to the membrane inside the circular area in the middle of the ointment washer Spread to evenly fill the dosage area Place O ring over washers Place glass washer on top of ointment washer and O ring Lift support ring Keeping slight pressure on glass washer 0 Washers will move to the bottom of support ring lift the entire assembly off the support tool pushing down gently on the glass washer to ensure the assembly sits at the bottom of the support ring N Fig 3 Assembly Diagram 11 Place the lock ring on the support ring with the two holes face up Inserting the two prongs of the hand tool into the corresponding holes of the lock ring screw the lock ring into the support ring Fig 4 It should fit snugly but do not tighten it too much or damage to the immersion cell may result Turn the assembly over for upright orientation z ral TULL PLT r ANA Wee 2012 Hanson Research Corp 65 190 027 Rev C Page 6
6. ead The mini spin paddles should be 10 mm above the immersion cell 9 Install a vessel cover over each vessel and start test Vessel Cover Clamp Knob Adapter Ring Flat Bottom Vessel Mini Spin Paddle Immersion Cell Assembly Fig 7 SR8 Plus Configuration 2012 Hanson Research Corp 65 190 027 Rev C Page 10 of 13 Immersion Cell User Guide 3 Accessory Options 3 Accessory Options Recommended 91 030 062 Membranes 25 mm diameter x0 45 micron 100 pk Also available for Vision Dissolution Testers 74 105 152 Flat Bottom Vessel 74 105 203 Mini Spin Paddle PTFE Coated or 74 105 204 Mini Spin Paddle 316 Stainless Steel 74 104 163 Vessel Cover 74 104 155 Easi Lock Adapter Ring for Small Volume Vessel 74 104 211 Fixed Vessel Mount Sample Probe Adjustable 1 16 in 316 SS for automated sampling or 74 104 201 Manual Sampling Cannula 1 8 in PEEK for manual sampling Also available for SR8 Plus Dissolution Test Station 72 800 721 Small Volume Dissolution Kit Flat Bottom includes Mini Paddle PVDF 150mL Flat Bottom Vessel Vessel Cover Vessel Adapter Ring 72 800 722 Small Volume Dissolution Kits Flat Bottom Set 6 72 800 714 Vessel Adapter Kit adapter ring with clamp knobs only 72 300 232 Manual Sampling Cannula for manual sampling Page 11 of 13 65 190 027 Rev C 2012 Hanson Research Corp Immersion Cell User Guide 4 Specifications 4 Specifications Immersion Cell
7. ll 15 mm immersion cell assembly only 65 190 051 Immersion Cell 15 mm one cell assembly with tools 65 190 052 Immersion Cells 15 mm set 6 with tools Page 3 of 13 65 190 027 Rev C 2011 Hanson Research Corp Immersion Cell User Guide 1 Introduction 1 1 3 Immersion Cell Tools The sets with tools 65 190 051 and 65 190 052 include 1 Support Tool 2 Hand Tool 3 Installation Rod 4 O Height Spacer for use with SR8 Plus only Fig 1 Immersion Cell Tools 2012 Hanson Research Corp 65 190 027 Rev C Page 4 of 13 Immersion Cell User Guide 2 installation 2 Installation The immersion cell can be installed in the flat bottom small volume vessel on the Hanson Vision Classic 6 Vision Elite 8 or SR8 Plus dissolution tester As an added option manual sampling probes can be added for sampling 2 1 Components The immersion cell contains several components listed below The membrane is sold separately but is pictured here to illustrate position _ Glass washer Oring 7 Ointment washer Membrane Orifice washer upport ring Fig 2 Immersion Cell Components 2 2 Immersion Cell Assembly The immersion cell must be properly assembled prior to use to ensure it functions properly Follow the procedure below Refer to Fig 1 Immersion Cell Tools Fig 2 Immersion Cell Components and Fig 3 Assembly Diagram Orient the support ring so that it is upside down l
8. of 13 Immersion Cell User Guide 2 installation 2 3 Immersion Cell Installation 1 With media in the vessels and once the temperature is stable loosely screw the installation rod into one of the two holes on the top of the immersion cell 2 Lower the immersion cell slowly into the vessel Fig 5 3 Unscrew the installation rod and remove from the vessel i lt Installation Rod Fig 5 2 4 Immersion Cell Removal 1 Use installation rod to remove the immersion cell from the vessel 2 5 Installing the Immersion Cell in a Dissolution Tester 2 5 1 For Use with a Vision Elite 8 Tester 1 Raise the drive head to its highest position 2 Remove any basket shafts or paddles already installed 3 Install the Easi Lock Adapter Ring for Small Volume Vessel into the hole where the 1L vessel would normally mount and turn clockwise to lock into place 4 Carefully insert the small volume vessel into the adapter ring and secure in place with the clamp knobs Repeat steps 3 4 for each small volume vessel used 5 Fill each vessel with desired media volume cover the vessels and allow the bath and media to reach desired operating temperature Page 7 of 13 65 190 027 Rev C 2012 Hanson Research Corp Immersion Cell User Guide 2 installation 6 Install mini spin paddles by screwing into spindle shafts tighten securely 7 Assemble all immersion cells remove covers and place each into a vessel using the installation rod
9. rod Unscrew rod and remove after placement Lower the mini spin paddles to 10 mm above the immersion cell Install a vessel cover over each vessel and start test For Use with an SR8 Plus Tester Raise the drive head to its highest position Install the adapter ring into the hole where the 1L vessel would normally mount and secure with the clamp knobs on the base plate Carefully insert the small volume vessel into the adapter ring and secure in place with the clamp knobs Repeat steps 2 3 for each small volume vessel used Install mini spin paddles in drive head with about 2 in showing above the top of the drive head Adjust the paddle height a Adjust the lock collars on each of the two guide rods to 1 above the rod mount see Fig 7 b Lower the drive head to its lowest position touching the lock collars c Lower each paddle until it touches the bottom of the vessel then lock each paddle shaft in position d Raise the drive head to its highest position and insert the O height spacer above the lock collar on one of the guide posts 65 190 027 Rev C 2012 Hanson Research Corp Immersion Cell User Guide 2 installation 6 Fill the vessel with desired media and volume and allow the bath and media to reach desired operating temperature 7 Assemble all immersion cells remove covers and place each into a vessel using the installation rod Unscrew rod and remove after placement 8 Lower the drive h
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