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1. Product Catalogue 2008 A AbESIN St RIEN Dom CONTENTS 2 The Product Catalogue shows the specifications of the full range of Aber majority of products and accessories Biomass Monitor systems available from Aber Instruments in biotech Part numbers materials and nology applications There is a detailed specifications are subject to change and the section on probe options including product catalogue should be used as top entry and side entry probes ina range a guide Users should obtain the latest of sizes with options for FDA certification product information from either Aber and a comparison of the technical Instruments or the local distributor Page Instruments BM200 3 BM200 Panel mount 4 BM220 5 BM230 6 LCA920 7 Probes Probes 8 2mm Probes 9 25mm Probes 10 Tri clamp Probes LI Port Adaptors 12 Probe Testers 3 Validation Malidation Certification 14 Software Aber Scan Software 15 AberLog Gold Software 15 Extension Cables 16 Spare Parts 17 Head Amplifiers 17 Probe Simulator 17 Ground Straps 17 Retaining Ring 17 Phoenix Connectors 17 Manuals 18 Other spares 18 Instrument Technical Specifications 19 rm Aber Instruments Limited A fa F R 5 Science Park Aberystwyth Ceredigion SY23 3AH UK Telephone 44 0 1970 636300 Fax 44 0 1970 615455 INSTRUMENTS E mail sales aberinstruments com Website www aberinstruments com System includes Biomass Monitor 200 Lab version 2900 20
2. Biomass Monitor 200 single channel probes ordered separately 2900 00 Biomass Monitor 200 2300 00 Head Ampiifier with 2 metre cable 2350 00 Probe Simulator 124 06 Mains lead Country specific 2900 09 Biomass Monitor 200 User Manual 1015 02 25mm probe retaining ring if 25mm probe supplied Software phoenix connector and USB lead ABER INSTRUMENTS In 2006 Aber Instruments introduced their latest innovation into the market with the Biomass Monitor 200 This new version is in response to the demand in the industry for a lower cost unit that is simple to use flexible with communications and that will meet the strict validation requirements of the manufacturing process including GAMP4 compliance In addition to the usual options for communications the instrument has a USB port for connection to a PC together with Aber data logging software Aber workbench 200 Measures live biomass ON LINE Dedicated to a single bioreactor Perfect for Cell Culture microbial bacteria and plant cells Compact and simple to evaluate and use Designed to GAMP4 e IQ OQ documentation optional Options For probe types see pages 8 11 For Validation options see page 14 Part number 2900 62 For extension cables see page 16 Profibus and devicenet other options available on request Aber Instruments Limited 5 Science Park Aberystwyth Ceredigion SY23 3AH UK Telephone 44 0 1970 63630
3. 2300 00 Head Amplifier with 2 Metre Cable 2350 00 Probe Simulator Ground Straps 2113 15 Ground strap for Head Amplifier 1116 15 Ground strap for Head Amplifier 2mm probes 25mm probes Retaining Ring Phoenix Connectors 1015 02 25mm Probe retaining ring 1660 06 4W Phoenix connector amp Backshell for Stainless Steel probes kit for BM200 4 20 mA output 1662 06 2W Phoenix connector amp Backshell kit for BM220 4 20 mA output 1663 06 14W Phoenix connector amp Backshell kit for BM220 PLC connectors Ez rm Aber Instruments Limited 4 A fa F R 5 Science Park Aberystwyth Ceredigion SY23 3AH UK kq Telephone 44 0 1970 636300 Fax 44 0 1970 615455 2 INSTRUMENTS E mail sales aberinstruments com Website www aberinstruments com Manuals 2900 09 2400 09 2200 09 2700 09 9200 09 1476 09 Biomass Monitor 200 User Manual Biomass Monitor 210 User Manual Biomass Monitor 220 User Manual Biomass Monitor 230 User Manual Live Cell Analyser 920 User Manual Probe Tester Manual Misc spares 1901 06 1902 06 1118 06 1075 02 Pipette 0 10 ml Oml Pipette Tips Pack of 25 Probe O ring BS210 FDA approved silicone 25mm Blanking plug stainless steel General Specifications all Biomass Instrumentation 19 Instrument Type Specification Lab 200 PM200 BM210 BM220 BM230 LCA920 Capacitance range n nee n pon 0 to 200pF em yes yes Oto400pF no no ys ys ys ye Resolut
4. R 5 Science Park Aberystwyth Ceredigion SY23 3AH UK a Telephone 44 0 1970 636300 Fax 44 0 1970 615455 menm INSTRUMENTS E mail sales aberinstruments com Website www aberinstruments com 12mm Annular probes 9 STRAIGHT PGI3 5 HEX NUT FLANGE 16mm Dia STRAIGHT PROBES Part Part Number number Serial Overall with without Description number Dimensions certificate certificate prefix 1922 52 Probe Annular Electrodes 12 x 100mm Stainless Steel Fortron 1923 52 Probe Annular Electrodes 12 x 200mm Stainless Steel Fortron 1925 52 Probe Annular Electrodes 12 x 300mm Stainless Steel Fortron 1927 52 1851 52 Probe Annular Electrodes 12 x 450mm Stainless Steel Fortron PGI3 5 PROBES 1924 52 Probe Annular Electrodes 12 x 200mm Stainless Steel Fortron 1926 52 1869 52 Probe Annular Electrodes 12 x 300mm Stainless Steel Fortron TBLAX 393 343 300 1928 52 1862 52 Probe Annular Electrodes 12 x 450mm Stainless Steel Fortron TBRAX 543 493 400 Fortron PPS polyphenylene sulphide This material has excellent strength and resistance to repeated steam sterilisations and has USP class VI and FDA 21 CFRI77 2415 accreditation for repeated food contact Aber Instruments Limited A B R 5 Science Park Aberystwyth Ceredigion SY23 3AH UK Telephone 44 0 1970 636300 Fax 44 0 1970 615455 INSTRUMENTS _ E mail sales aberinstruments com Website www aberinstruments co
5. 0 Fax 44 0 1970 615455 E mail sales aberinstruments com Website www aberinstruments com BM 200 Panel Mount Launched in 2007 the panel mount version of the Biomass Monitor 200 is dedicated to cGMP The Biomass Monitor Model 200 was produced in response to the demand in the industry for a lower cost unit that is simple to use flexible with communications and that will also meet the strict validation reguirements of the manufacturing process including GAMP 4 compliance The unit is designed to be dedicated to single bioreactor ideal for cGMP and overcomes the inconvenience of running multiple cables to bioreactors These new features combine to make the BM200 the most customer orientated device for live cell mass monitoring System includes e Measures live biomass ON LINE 2920 20 Biomass Monitor 200 Panel mount single channel probes ordered separately e Perfect for Cell Culture microbial bacteria 2920 00 Biomass Monitor 200 2300 00 Head Amplifier with 2 metre cable 2350 00 Probe Simulator e Front protected to IP65 124 06 Mains lead Country specific e Designed to GAMP4 2900 09 Biomass Monitor 200 User Manual 1015 02 25mm probe retaining ring if 25mm probe supplied Ideal for cGMP production Software Phoenix connector and USB lead Dedicated to a single bioreactor and plant cells e IQ OQ documentation optional Options For probe types see pages 8 11 For Validat
6. 0 User Manual 1015 02 25mm probe retaining ring if 25mm probe supplied Where indicates the number of channels required this is also the number of Head Amplifiers that will be provided with the system Profibus option please order with system part number 2700 30 The Biomass Monitor 230 has been designed for use in a production environment To ensure simplicity of use there are minimum set up options with password protection for cGMP The instrument is enclosed within an IP65 stainless steel cabinet so there are no additional enclosure costs It has an integral multiplexor and like the model BM220 can be used with up to 4 probes The model 230 has been widely used in cGMP by the major Biopharma companies The system can also be supplied with a profibus module e Measures live biomass ON LINE and can be expanded for up to 4 bioreactors Suitable for animal yeast filamentous fungi bacteria and plant cells e Robust within an IP65 enclosure ideal for pilot plant or production Ideal for cGMP and can be provided with full IQ OQ documentation optional Options For probe types see pages 8 11 For Validation options see page 14 Part number 2700 62 For extension cables see page 16 For AberLog Gold software see page 15 Profibus and devicenet other options available on reguest Aber Instruments Limited t e SA A fa F R 5 Science Park Aberystwyth Ceredigion SY23 3AH UK Telepho
7. 00 Fax 44 0 1970 615455 INSTRUMENTS E mail sales aberinstruments com Website www aberinstruments com ABER INSTRUMENTS Aber Instruments Limited 5 Science Park Aberystwyth Ceredigion SY23 3AH UK Telephone 44 0 1970 636300 Fax 44 0 1970 615455 E mail sales aberinstruments com Website www aberinstruments com
8. 1 5 inch Tri clamp flange with certificate 1931 52 Probe Flush Electrodes 25 x 70mm Stainless Steel Fortron 63 9 25 70 163 with 2 inch Tri clamp flange with certificate Fortron PPS polyphenylene sulphide This material has excellent strength and resistance to repeated steam sterilisations and has USP class VI and FDA 21 CFR177 2415 accreditation for repeated food contact rm Aber Instruments Limited A fa F R 5 Science Park Aberystwyth Ceredigion SY23 3AH UK Telephone 44 0 1970 636300 Fax 44 0 1970 615455 INSTRUMENTS E mail sales aberinstruments com Website www aberinstruments com Port Adaptors 12 The port adaptors are designed to allow the The New Brunswick version is similar but 2mm straight Aber probes to be fitted into fits a male threaded port on either the top either Braun or Applikon 19mm 3 4 top plate or side entry port plate female port fitting lt C REAR FERRULE a an FERRULE SEALING O RING b WETTED O RING a SECTION A A SECTION B B MATING THREAD 1263 1265 1295 1296 Wetted Sealing Sealing Part No Description O ring a O ring b washer c Mating thread 1265 12 19mm Braun Silicone FDA EPDM 26 x Imm PITCH Sartorius Adaptor 18 x 30 26 7 x 1 78 1295 12 12mm Braun Silicone FDA EPDM 26 x Imm PITCH Sartorius Adaptor 10 78 x 2 62 26 7 x 1 78 1263 12 19mm Applikon Adaptor Silicone FDA EPDM 3 4 BSP 18 x 3 0 26 7 x 1 78 1296 12
9. 12mm Applikon Adaptor Silicone FDA EPDM 3 4 BSP 10 78 x 2 62 26 7 x 1 78 269 12 19mm Brunswick Adaptor Silicone FDA Silicone FDA 26 x Imm PITCH 18 x 3 0 19 x 3 5 x 2 273 12 I2mm Brunswick Adaptor Silicone FDA Silicone FDA 26 x Imm PITCH 10 78 x 2 62 I9x3 5x 2 rm Aber Instruments Limited A fa F R 5 Science Park Aberystwyth Ceredigion SY23 3AH UK Telephone 44 0 1970 636300 Fax 44 0 1970 615455 INSTRUMENTS E mail sales aberinstruments com Website www aberinstruments com Probe Tester 1476 00 LCD version 1476 60 LCD version renewal certificate 1475 00 Non LCD version 1475 60 Non LCD version renewal certificate 1476 09 Probe tester manual for LCD version and non LCD version The Aber Instruments Probe Tester has check the continuity between each electrode been specially designed to carry out checks on and the Head Amplifier socket The complete the integrity of any type of probe used with the test procedure checks the health of a probe and full range of Biomass Monitors 200 210 220 230 its ability to perform correctly amp 920 Both testers are supplied new with a There are two versions of the Probe Tester calibration certificate 1475 00 is a simple pass or fail device intended The tester will automatically run through a for production environments 476 00 also has a sequence of tests checking a probe for internal LCD display that allows the user to quantify and corrosion and leakag
10. Live Cell Analyser 920 off line only IOQ Aber Instruments Factory Acceptance Certification 9205 62 Live Cell Analyser 920 on line and off line IOQ Aber Instruments Factory Acceptance Certification Probe Certificate of Conformance Probe Simulator Certification 2350 60 Biomass Monitor Probe Simulator Certification 1000 61 Probe Certificate of Conformance 1000 62 Probe OQ Documentation 1476 60 Probe Tester LCD version renewal certificate 1475 60 Probe Tester non LCD version renewal certificate rm Aber Instruments Limited A fa F R 5 Science Park Aberystwyth Ceredigion SY23 3AH UK Telephone 44 0 1970 636300 Fax 44 0 1970 615455 INSTRUMENTS E mail sales aberinstruments com Website www aberinstruments com AberScan Software bea Fevers The AberScan Software is for use specifically with STARS the Biomass Monitor Models 210 8 220 to record many sen Cemara thn pei Can fn frequency scan data The software records the capacitance and conductance values continuously The spectra produced are analysed to derive additional process parameters including dielectric increment cole cole alpha and critical or characteristic frequency fc that can be used as sign posts or for monitoring key events during the fermentation process Designed to run with Windows XP or Vista 4500 00 AberScan Software package 4500 07 AberScan Software 4500 09 AberScan Software Manual AberLog Gold is a data logging software pack
11. age that can used with most Biomass Monitor systems including models 210 220 230 amp 920 It has a range of features including logging of capacitance and conductivity measurements over user defined logging intervals multiple channel logging data manipulation and exporting of data in csv format for use with other graphical packages gm La A Conductivity mSlem 17 03 2008 14 14 43 17 03 2008 14 15 13 Designed to run with Windows XP or Vista 4600 00 AberLog Gold Software package 4600 07 AberLog Gold Software 4600 09 AberLog Gold Software Manual rm Aber Instruments Limited S A fa F R 5 Science Park Aberystwyth Ceredigion SY23 3AH UK l A A Telephone 44 0 1970 636300 Fax 44 0 1970 615455 INSTRUMENTS E mail sales aberinstruments com Website www aberinstruments com Extension Cables 1601 24 05 1601 24 10 1601 24 15 1601 24 20 1601 24 25 3 5 metre extension cable SHAX 5 I0 metre extension cable SHAX 10 I5 metre extension cable SHAX 15 20 metre extension cable SHAX 20 25 metre extension cable SHAX 25 Cables are available in lengths up to 100 metres intermediate lengths can be made to order Aber Instruments Limited A fa F R 5 Science Park Aberystwyth Ceredigion SY23 3AH UK Telephone 44 0 1970 636300 Fax 44 0 1970 615455 INSTRUMENTS E mail sales aberinstruments com Website www aberinstruments com Spare Parts Head Ampiifier Probe Simulator
12. e between the electrodes track the changes of probe condition An additional test cable allows the user to rm Aber Instruments Limited A fa F R 5 Science Park Aberystwyth Ceredigion SY23 3AH UK Telephone 44 0 1970 636300 Fax 44 0 1970 615455 INSTRUMENTS E mail sales aberinstruments com Website www aberinstruments com Validation Certification All these validation packages include Aber The Instruments are shipped with Instruments generated release calibration OO appropriate calibration certificates and factory documentation and the probe certificate of completed IOQ acceptance documents along conformance suitable for compliance in with a blank set of IO and OQ documents to be pharmaceutical production environments used to replicate these tests at the client site 2900 62 Biomass Monitor 200 Lab version and Panel mount Probe Certificate of Conformance IOQ Aber Instruments Factory Acceptance Certification Probe Simulator Certification 2400 62 Biomass Monitor 210 Probe Certificate of Conformance IOQ Aber Instruments Factory Acceptance Certification Probe Simulator Certification 2200 62 Biomass Monitor 220 up to 4 channels Probe Certificate of Conformance IOQ Aber Instruments Factory Acceptance Certification Probe Simulator Certification 2700 62 Biomass Monitor 230 up to 4 channels Probe Certificate of Conformance IOQ Aber Instruments Factory Acceptance Certification Probe Simulator Certification 9200 62
13. e for counting cells Options For probe types see pages 8 11 For Validation options see page 14 Part number 2900 62 For extension cables see page 16 For AberScan software see page 15 For AberLog Gold software see page 15 rm Aber Instruments Limited A fa F R 5 Science Park Aberystwyth Ceredigion SY23 3AH UK Telephone 44 0 1970 636300 Fax 44 0 1970 615455 INSTRUMENTS E mail sales aberinstruments com Website www aberinstruments com Probe Options 8 Aber Instruments has a wide range of All probes are Electropolished and probes to suit all applications they are available Passivated Options for USP class VI and FDA in 12mm diameter ideal for small bio reactors CFR21 177 certificates and 25mm diameter for larger vessels All probes are available fully certified 12mm Annular Probe 25mm Annular Probe 25mm Flush Probe Tri clamp All probes supplied by Aber Instruments will work in all situations however the annular probe performs best in highly aerated systems In cell culture in large vessels the flush probe is more robust and there is little or no advantage using the annular probe 25mm Large vessels Cell Culture Microbial Bacterial 25mm Annular Alternative Recommended Recommended 25mm Flush Recommended Alternative Alternative 2mm Small vessels top mounted Cell Culture Microbial Bacterial 12mm Annular Recommended Recommended Recommended ponn rm Aber Instruments Limited i Pa A fa F
14. ion display 0 pF cm 0 l pF cm 0 pF cm 0 pF cm 0 IpF cm 0 1 pF cm Detection level for typical applications Microbial g l 0 02 0 5g l 0 02 O 5g 1 0 02 O 5g l 0 02 0 58 1 0 02 O 5g l 0 02 0 5g l Cell culture cells mi 104 10 gt 104 10 gt 104 105 104 105 104 105 104 10 Conductivity range 0 to 40mS cm es es es es es es Optional DI enn a enn 0 to 80mS cm yes yes yes yes yes yes note 2 Communications 4 to 20mA yes yes yes yes yes yes note 3 note 3 RS232 no no ys yes ys ye USB2 yes ys no no n no Printer no no yes yes ko no yes Options Profibus es es no no es no Devicenet yes yes no no yes no Other options available J PC Software optional o ys ys yes yes no no Power Supply 10 230V 110 230V 110 230V 10 230V a c a c a C a C a C a C Environmental Size mm 270 W 270 W 310 W 310 WW 400 H 370H Height x Width x Depth 90 H 400 W 200 W 200 D 200 D 310 D 310 D 200 D 500 D IP rating IP40 IP65 IP40 front panel Weight Kg 65kg 65kg 6 0kg 6 0kg 2kg 7 85kg Notes l Microbial IpF cm 0 5 to 5g l Cell culture IpF cm 104 to 10 cells ml 2 Oml sample cell and on line input 3 Can be configured for 0 to 20mA Head Amplifier All instruments Size in mm 65W x 50H x 150D Weight Okg rm Aber Instruments Limited A fa F R 5 Science Park Aberystwyth Ceredigion SY23 3AH UK Telephone 44 0 1970 6363
15. ion options see page 14 Part number 2900 62 For extension cables see page 16 Profibus and devicenet other options available on reguest rm Aber Instruments Limited A fa F R 5 Science Park Aberystwyth Ceredigion SY23 3AH UK Telephone 44 0 1970 636300 Fax 44 0 1970 615455 INSTRUMENTS E mail sales aberinstruments com Website www aberinstruments com BM 210 220 5 Biomass Monitor 210 System includes 2400 20 Biomass Monitor 210 single channel probes ordered separately 2200 00 Biomass Monitor 210 2300 00 Head Amplifier with 2 metre cable 2350 00 Probe Simulator 124 06 Mains lead Country specific 2400 09 Biomass Monitor 210 User Manual 1015 02 25mm probe retaining ring if 25mm probe supplied Biomass Monitor 220 System includes 2200 20 4 Biomass Monitor 220 4 input single channel probes ordered separately 2200 00 Biomass Monitor 220 2300 00 Head Amplifier with 2 metre cable 2350 00 Probe Simulator I24506 Mains lead Country specific 2200 09 Biomass Monitor 220 User Manual 1015 02 25mm probe retaining ring if 25mm probe supplied Where indicates the number of channels required this is also the number of Head Amplifiers that will be provided with the system ABER INSTRUMENTS The Biomass Monitor 220 combines the latest advances in radio frequency dielectrics with an integrated software programme that allo
16. m 25mm probes 1852 52 1858 52 Probes Part Part Number number Serial Approx with without Description number Dimensions certificate certificate prefix Y 1934 52 1832 52 Probe Flush Electrodes poun PAN 25 x 175mm Stainless Steel Fortron SBKFS 25 175 265 Probe Flush Electrodes pan lis 25 x 75mm Stainless Steel Fortron SBSFS 25 75 165 W 1933 52 1833 52 Probe Flush Electrodes 25 x 75mm Stainless Steel Fortron for use with some Braun safety ports Probe Annular Electrodes 25 x 96mm Stainless Steel Fortron for use with some Braun Safety ports Fortron PPS polyphenylene sulphide This material has excellent strength and resistance to repeated steam sterilisations and has USP class VI and FDA 21 CFR 177 2415 accreditation for repeated food contact rm Aber Instruments Limited A fa F R 5 Science Park Aberystwyth Ceredigion SY23 3AH UK Telephone 44 0 1970 636300 Fax 44 0 1970 615455 INSTRUMENTS E mail sales aberinstruments com Website www aberinstruments com Tri clamp Probes Probes Part Part Number number Serial Approx with without Description number Dimensions certificate certificate prefix Z Ew x 1929 52 1951 52 Probe Flush Electrodes 25 x 175mm Stainless Steel Fortron SBKFA 50 4 25 175 260 with 1 1 5 inch Tri clamp flange with certificate 1930 52 1950 52 Probe Flush Electrodes 25 x 70mm Stainless Steel Fortron SBJFA 50 4 25 70 163 with 1
17. ne 44 0 1970 636300 Fax 44 0 1970 615455 INSTRUMENTS E mail sales aberinstruments com Website www aberinstruments com Live Cell Analyser 920 7 The Live Cell Analyser 920 on line and off line system includes 9200 20 Live Cell Analyser 920 off line and on line probes ordered separately 9200 09 Live Cell Analyser 920 User Manual 2300 00 Head Amplifier with 2 metre cable 2350 00 Probe Simulator 124 06 Mains lead Country specific 8091 06 Wash Bottle 1901 06 1 10ml Pipette 8039 15 Drain tube assembly The Live Cell Analyser Off line only System includes 9200 00 Live Cell Analyser 920 off line only 9200 09 Live Cell Analyser 920 User Manual I24506 Mains lead Country specific 8091 06 Wash Bottle 1901 06 1 10mi Pipette 8039 15 Drain tube assembly The Live Cell Analyser 920 is quite unique in allowing the live cell concentration to be measured on line and at the same time it can be used to measure off line samples The sample chamber is 10ml with a stirrer and temperature control to provide optimum conditions for the culture Ideal for busy laboratories and for measuring highly clumped cells or for cells attached to carriers e Measures live biomass in samples and ON LINE Suitable for animal yeast filamentous fungi bacteria and plant cells Simple to use and no need to add dyes or dilute samples Saves valuable laboratory tim
18. ws both live cell mass monitoring or control as well as radio frequency scanning The model 220 has an integral multiplexer allowing up to 4 fermentors to be monitored to expand the system you simply add an extra Head Amplifier s and probe s as all the additional electronics are built in The frequency scanning option can provide additional information on the metabolic state of the culture this makes the instrument ideal for operation in research or process control A single channel only version the Biomass Monitor 210 is also available e Measures live biomass ON LINE and can be expanded for up to 4 bioreactors Perfect for Cell Culture microbial bacteria and plant cells Frequency Scanning Ideal for research and process development Options For probe types see pages 8 For Validation options see page 14 BM 210 Part number 2400 62 BM 220 Part number 2200 62 For AberScan software see page 15 For AberLog Gold software see page 15 For extension cables see page 16 Aber Instruments Limited 5 Science Park Aberystwyth Ceredigion SY23 3AH UK Telephone 44 0 1970 636300 Fax 44 0 1970 615455 E mail sales aberinstruments com Website www aberinstruments com System includes 2700 20 A Biomass Monitor 230 input 4 channel probes ordered separately 2700 00 Biomass Monitor 230 2300 00 Head Amplifier with 2 metre cable 2350 00 Probe Simulator 2700 09 Biomass Monitor 23

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