TDM フェノバルビタール
Contents
1. 12. 1 TDM 2 1 PB PB PB 37C 37C 2gL 180gL 270 50zL 53 37C 265 T II 700nm TDM
3. 2 3 4 5 3 1 01 1 121 20 01
4. 15 40 g mL 1 1 0g mL 1 0 110 0 200 2 0 g mL 5 ug mL 1 60 80
5. 6 7 PB HBs HIV AIDS HCV PB PB 1912 Hauptmann 2 3mg kg 12 18
6. 40 50 p 15 40ug mL Farwell
7. 2 1 3 to 1 1 EDTA 15 30C 7 2 8C 3 20 3 2 4 2 1 20mg dL
8. PB PB 4 to 5 x x 1 2 8C 2 2 TDM PB 36mL x 1 PB 10mLx1 1 Buchthal F Syensmark O Serum concentrations of diphenylIhydantoin phenytoin and phenobarbital and their relation to therapeutic and toxic effects Psychiat Neurol Neurochir 74 117 135 1971 Farwell R Lee Y J Hirtz D G Sulzbacher S Ellenberg J H Nelson K B Phenobarbital for febril s
9. 20mg d 500mg dL 50mg dL 2500 5 450U L to zg mL SR 1000 019 ie 1000 024 ay 2 0 1000 009 1000 0 11 2000 0 04 1000 0 21 1000 0 28 or 0 nooo 026 2000 008 2500 0 10 1000 013 1000 0 16 1000 017 1000 014 4000 007 3000 010 5000 005 400 055 2000 002 1000 033 1500 0 12 2000 015 7000 000 3
10. 80 120 10 1 3 7170S 0 8 80 ug mL 1 N 60 r 0 992 0 95x 021 2 N 103 r 0992 y 096x 0 88 6 1 1 HIV HBV HCV 2 PB PB 2 1
11. 200134 004 13A2X00197218104 2012 2 4 2009 1 3 30401000 TDM 1 2 3 4 5
12. eizures effects on intelligence and on seizure reCurTenCe N Engl J Med 322 363 369 1990 Kutt He Penry K Usefulness of blood levels of antiepileptic drugs Arch Neurol 3 283 288 1974 Waddell W J Butler T C The distribution and excre tion of phenobarbital J Chn Invest 36 1217 1226 1957 5 51 1 131 141 2004 6 IN 3 0120 249 977 FAX 0120 247 477 13 5
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