No.32
Contents
1. IGFBP 2 IGFBP 2 IGFBP 2 1GFBP 2 IGFBP 2 IGFBP 22. Gs PWS 2 GH hGH IGF 1 NCGS 50 000 200 000 27 9 15 GH 3 GH 26 29 49
3. 1202 20 hGH 9 Kamp ISS 035mg kg hGH Galatzer Laron 1SS 50 hGH hGH GH 39 54 g 2 7 6 cm 9
4. 25 10 IGFBP 2 2 IGFBP 2 10 6 38 19 9 7 12 8 IGFBP 2 mRNA IGFBP 2 DEXA IGFBP_ 2 IGFBP 2 mRNA TGF L
5. BMISDS 2 IGFBP 2 IGFBP 2 mRNA IGFBP 2 IGFBP 2 IGFBP 2
6. 1700BZZ004796 74 70394000 BC Bmg GroWjector 791 0395 131 1 659 0021 3 19 2010 12 19AFBZX00104000 74 JMDN 70391000 BC Bmg BD 3
7. 1IR S1 ValB12 TyrB16 TyrB24 IR L1 TyrB25 ValA3 ThrA8 CT S2 L1 2 1 2 CR Fn1 3 1 3 ID Ex11 111 IR B TM JM TK CT C S1 2 1 2 IGF 1 S1 L1 ID S2 Fn1 Fn2 S1 S2 School of Molecular and Biomedical Science The University of Adelaide Adelaide South Australia 5005 Australia Fabry Fn1 IGF I IGF I
8. 2 1 2 1 S1 L 1 ID 2 S2 S1 ID Fn 1 Fn2 AB IGF IGF I IGF T 70 67 4 C 3 og 3 1GF 1 IGF II 2 IR IGF IGF IR IGEF I C Ala8 Met59
9. PWS GH GH Endocrinology amp Diabetes Research Unit Schneider Children s Medical Center and Sackler School of Medicine Tel Aviv University Israel GH So hGH GnRH hGH GnRH SHOX ISS 5 4 SD 2 3 13 SD 17 16 SD
10. GH GH hGH GHD GH GH PWS GH
11. Kabi Serono hGH hGH hGH p hGH GHD 1985 p hGH Creutzfeldt Jakob p hGH hGH rhGH rhGH hGH GHD 0 rhGH GH 1 Albertsson Wikland ISS 49 33 pg kg 50 67 pg kg hGH 1 3SD SD Wit 34 pg kg 53 g kg hGH 1SS 53 ug kg
12. GH SGA GH SGA hGH GH 7 000 70 93 GH 2010 12 GH GH GH 2011 12 GH
13. 659 0021 3 19 960 2152 1 2010 4 3 OT 000 0 0000 KO 12 MED 102 0074 4 2 15 MediArt Ltd 2011 8 4
14. IGFBP 2 mRNA IGFBP 2 PTEN IGFBP 2 PTEN IGFBP 2 IGFBP 2 IGFBP 2 IGFBP 2
15. 3 IGEFBP 2 3 2 IGFBP 2 IGEFBP_ 2 IGFBP 2 CNS 1Centre for Hormone Research and Department of Endocrinology amp Diabetes Murdoch Childrens Research Institute Royal Children s Hospital and University of Melbourne Victoria Australia Department of Women and Child Health University Hospital for Children amp Adolescents University of Leipzig Germany 2
16. IGF I ALS IGFBP 3 GH IGF 1 NR I 1GF I IGF I IGF IR 6 S1 44 IGF IR IGF 1 Arg36Gln IGF I 36 IGF IR CR 1GF II A Beckwith Wiedemann Silver Russell ot
17. IGFBP 2 1GFBP 2 IGFBP 2 IGFBP 2 IGF IGFBP 2 IGF 1 IGFBP 2 IGFBP 3 IGFBP 2 IGFBP 2 IGF I IGFBP 2 IGF
18. IGEF II IGF IR 1IGF IR 92N 0 1GF 1 Arg36Gln IGF I IGFBP 3 IGF IR IR IGF_R Arg108Gm Lys115Asn 2003 IGF IR 108 115 L1 S1 IGEF_IR
19. Arg59Stop IGF IR Arg709GIn TGF IR Fn2 Val599Glu TGF IR Glul050Lys ATP Gly1125Ala 18 1106 mRNA NMD IGEF_IR MU IGFBP 2 2 IGFBP 2 at the Interface of Growth and IMetabolism Implications for Childhood Obesity Matthew A Sabin MB BS PhD Vincenzo C Russo PhD Walid J Azar BSc Steven W Yau BSc Wieland Kiess MD George A Werther MD IGF
20. PTEN PI3 Akt IGFBP 1 2 2 1 IGFBP 1 IGFBP 2 1 IGFBP 1GFBP 2 IGEF I 1GF II 1GFBP SI 9 0 C MPN 00 rf IGFBP 2 IGF IGF IGF IGFBP 2 IGF IGFB
21. hGH hGH 3 cm GH catch up GH PWS PWS hGH
22. IGFBP 1GF 1 IGF I IGFBP IGEF IR IGFBP IGF ITR GH IGF GH GH GH IGF GHR Stat5bb GH IGF I IGFBP 3 ALS Stat5b ALS IGFBP 3 IGFBP IGF 1 IGF I 4 5 70 25 8 IGF I
23. IGFBP GH TGF TIGF I GH 6 TGFBP 1 IGFBP 6 IGFBP IGF I IGF II IGFBP l IGFBP 3 IGFBP 4 IGF I IGF I IGFBP 2 IGFBP 5 IGFBP 6 IGF IGFBP IGF IGFBP 1 1GFBP 1 IGF I a5 1 10 FAK
24. 37 OZGROW 3 000 9 GH Moshang GH 1 262 Childhood Cancer Survivor Study CCSS 14108 GH 361 20 KIGS Justel Shalet GH GH XY
25. rhGH GH GH QOL hGH rhGH CHD GH
26. IGF I C IGF IR CR 2 1 1 harmonic oscillator IGF IR IR B IGF 1 IGF IR Tyr1131 Tyr1135 Tyr1136 Tyr950 TRS 1 2 Shc 2 IRS Shc PI3K_ AKT PKB RAS MAPK IGF IGFBP IGF I IGF II 6 IGFBP IGFBP IGF 1 3 IGF IL 6
27. 1IGFBP IGF IGF IR IR 1GF IR IR 2 qa BB A B IGF 1 L1 Fn1 Fn2 ID IGF T C IGF IR CR a
28. GHL IGF 1 IGFBP 2 JCR Growth Hormone Therapy Emerging Dilemmas Zvi Laron MD PhD hc GH 20 100 1910 Cushing 1921 Evans Long 1937 Young 1958 Raben GHD hGH
29. GH _ 6 GH IGF Molecular Mechanisms Underlying Insulin Like Growth Factor Action How Mutations in the GH IGF Axis Lead to Short Stature Briony E Forbes PhD IGF I IGF II IGF 1 GF IR IGF IGE 1 IGF II IGF IGF 1GFBP 1 6 IGF 1IGF IGFBP 3 IGFBP 5 acid labile subunit ALS 150kDa TIGF
30. ji ellatelW2aitel Ye ejj4 e Te eIei4 a e e7e 7 7 6 7e l0lae gt eoP 8 0 gelirejglaE Ial jpW Kelreja ID ap ae Associate Editor Mitchell E Geffner MD Paitelej loli eliro io greelelaWelale orojiite ciohM Colalel lt o Kenialte MD PER published by Y S MEDICAL MEDIA Ltd PTATRIC ND CN GREENS Rn 1 KN 3 CONTENTS 1 Zvi Laron MD PhD h c 2 GH IGF Briony E Forbes PhD IGEFBP 2 3 Matthew A Sabin MB BS PhD Vincenzo C Russo PhD Walid J Azar BSc Steven W Yau BSc Wieland Kiess MD George A Werther MD PE Volume 8 No4 Laron GH IGF 1
31. P 2 IGFBP 2 IGFBP IGFBP SGA IGFBP 2 IGFBP 2 IGFBP 2 IGFBP 2 IGFBP 2 2010 Hedbacker IGFBP_ 2
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