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1. i 5 896 ee 22. 15 3 31
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4. 1991 2001 13 2 MIRGS 2 TAS DNA wTAS A T Wooley etal J Electroanalytical chem 492 15 2000 MicroCHIPS Advion BioSciences Affymetrix Apibio Caliper Life Sciences Ciphergen Biosystems Colibrys CombiMatrix EAGLE RESEARCH AND DEVELOPMENT GENEFLUIDICS Nanolayers NanosySs Nanogen Optobionics Spinelix www mchips com www advion com www affymetrix com www apibio com www caliperls com www colibrys com www eaglerd com www genefluidics com www nanolayers com WWW hNanosys1hnc com WWwW hnanogen com www optobionics com www spinelix com
5. 12 4 10 amp 3 7 7 gt ____ METIS 5 18 9 27
6. http www nanogen com NanoMate HD System CSEM 2001 MEMS MOEMS microopto electromechanical system Semiconductor Nanopore Sensor SeNSe DNA RNA
7. Intuitive Surgical Inc http www intuitivesurgical com Computer Motion Inc http www computermotion com the operative system in robotic surgery 31 16 Integrated Surgical Systems http www robodoc com 2 1 7 Expanding the Scope of GI Given Imaging Ltd http www givenimaging com INTOUCH HEALTH http www intouch health com IN HO PKI N S Oitice of memesicatioes EDICAL INSTITUTIONS Phe A
8. 250 000 201 606 200 000 16 4493 191 508 181 951 172 905 Ml 49 539 150 000 139 Ng 126 339 132 890 100 000 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 1 110 Bspicom Business Intellisence The World Medical Market Report 200 000 180 000 160 000 140 000 Na 120 000 100 000 80 000 60 000 40 000 20 000 0 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 1 110 Bspicom Business Intelligence The World Medical Market Report J i i 1 29 6 58 5 28 9 1 87 25 8 ey G 24
9. Nanomedicine may be broadly defined as the comprehensive monitoring control construction repair defense and improvement of all human biological systems working from the molecular level using engineered nanodevices and nanostructures Nanomedicine Volume Basic Capabilities 1999 Zyvex Robert Freitas 10cm 10 100 m 10 100nm 1 1 J 201 23 6 o6 11 3 42 4 9 PS 2 67 60 1 wc 829 20 1 780 19 09 33 0 8 Biopharmaceutics Drug Delivery Drug Encapsulation
10. 1 GMP GMPI 1 2 3 4 ME 7 6 PL PL
11. Ep NanoChip R 14 TAS2006 Finland Poland Thailand Italy Australia 16 Combinatorial Chemisty 17 a ds 13 Applications Others 1 Micro amp Nano 15 Cell Handling amp Analysis Fluidics 14 5 eparaton Scienc 2 Micro amp Nano 13 Chemical Synthesis Fluidic Devices 12 Medical amp Clinical 3 Micro amp Nano 11 Genomics amp Fabricaton Proteomics 10 Basic Technologies Packaging amp nterlace amp Science Others 5 5ystem Technology 2 Mcro amp Nano Biology 8 Micro amp Nano Chemistry 7 Detection Technology 6 Material amp Surface 24
12. FDA Office of Combination Products 2002 12 24 FDA http www fda gov oc combination approvals html Absorbable Collagen Sponge with Genetically Engineered Human Protein Spinal Fusion Putty Paclitaxel Bluting Coronary Stent System Photodynamic Therapy Device Approval Information FluMistTM Influenza Virus Vaccine Live Intranasal Tositumomab and Iodine I 131 Tositumomab Demagraft Human Fibroblast Derived Dermal Substitute Glucose Monitor Insulin Pump Antibiotic Bone Cement Sirolimus Eluting Coronary Stent Lumbar Tapered Fusion Device with Genetically Engineered Human Protein Peginterferon alfa 2a in Combination with Ribavirin Fibrin Sealant Dermal Collagen Implants for Aesthetic Use 10 2000 gt
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17. ME ii koubo QOL Quality of Life 5 10 QOL PET 0 St HE MTBF I
18. 1C Evidence Based Needs Ee _ NR B Blioengineering Integrates physical chemical or mathematical sciences and engineering principles for the study of biology medicine behavior or health It advances Tundamental concepts creates knowledge Trom the molecular to the organ systems level and develops innovative Diologics materials processeSs Implants devices and informatics approaches for the Drevention diagnosis and treatment of disease for Datient rehabilitation and Improving health NIH 1997 7 xPhys i ome ue life or nature ome asawholeentity 10
19. Functional Drug Carriers Drug Discovery Implantable Materials Tissue Repair and Replacement Implant Coatings Tissue Regeneration Scaffolds Structural Implant Materials Bone Repair Bioresorbable Materials Smart Materials Implantable Devices Assessment and Treatment Devices NANOMEDICINE TAXONOMY Implantable Sensors Implantable Medical Devices February 2003 Sensory Aids Canadian Nanobusiness Alliance Retina Implants EtthB 4UUgilkEle EllRS3 Surgical Aids 0perating Tools Smart Instruments Surgical Robots OE OE Genetic Testing Ultra sensitive Labeling and Detection Technologies High Throughput Arrays and Multiple Analyses Imaging Nanoparticle Labels Imaging Devices Canadian NanoBusiness Alliance liliance nadienne du commerce chnolo Basic Life Proce
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22. l 60 1 1 rr TE ei lt 1 A DDS 1 5 a 29 e LA D 7 ry a pS AE CM OU OO 1 OL A OOL ODL 0 oO 65 70 75 80 85 90 5 10 15 2 0 6 5 30 2 2002 19 Projected qlobal deaths millions 2030 1136 974 _ 768 HIV 650 306 210 em me me ee Updated proj
23. ections of global mortality and burden of disease 2002 2030 WHO 2005 21 2006 9 13 NIH 20
24. sses 12 Sep 9 11 Oct 2 5 rr Oa a a Tire ea Dec 13 14 Inveslin in Medical Nagnnlechnnlnie5 EA a gt EE 13 14 December 2006 Royal Garden Hotel London pjp BE Jul 22 26 tg TIL tria Cg ante F Wiennai _ Austria TAS2006 Nov 5 9 TS2005 Tokyo Internatinmal Fnrum Aug 30 Sep 2 FDA FDA Oct 10 la DNA G C C 4
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